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(12) Patent Application Publication (10) Pub. No.: US 2014/0273689 A1 CARROLL Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2014/0273689 A1 CARROLL Et Al US 20140273689A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0273689 A1 CARROLL et al. (43) Pub. Date: Sep. 18, 2014 (54) NONWOVEN MATERALS COATED WITH Publication Classification FLUOROPOLYMER AND ANTIMICROBAL AGENT (51) Int. Cl. D6N3/00 (2006.01) A4ID 13/12 (2006.01) (71) Applicant: ALLEGIANCE CORPORATION, D6N3/04 (2006.01) McGaw Park, IL (US) (52) U.S. Cl. CPC .............. D06N3/0059 (2013.01): D06N3/047 (72) Inventors: Emily CARROLL, Arlington Heights, (2013.01); A4 ID 13/12 (2013.01) IL (US); Walter ISAAC, Lindenhurst, USPC .......................................................... 442/123 IL (US); Hallie KREITLOW, Highland Park, IL (US); Nick KROGMAN, (57) ABSTRACT Pleasant Prairie, WI (US) An article having a nonwoven material and a coating contact ing the nonwoven material, the coating comprising at least one fluorochemical and at least one antimicrobial agent. The fluorochemical comprises at least one fluoropolymer. The (21) Appl. No.: 14/191,199 add-on value of the at least one antimicrobial agent on the nonwoven material is less than 0.75% and the coating pro vides at least a 4-log reduction within 5 minutes when mea (22) Filed: Feb. 26, 2014 sured using AATCC Method 100. The at least one antimicro bial agent is selected from the group consisting of a benzalkonium salt, a benzethonium salt, a octenidine salt, a Related U.S. Application Data chlorhexidine salt, free base chlorhexidine, triclosan and combinations thereof. The coating provides at least a 2-log (60) Provisional application No. 61/799,443, filed on Mar. reduction within 5 minutes when measured using AATCC 15, 2013. Method 100. US 2014/0273689 A1 Sep. 18, 2014 NONWOVEN MATERALS COATED WITH Examples of materials typically having an AAMI Level 2 FLUOROPOLYMER AND ANTMICROBAL classification include articles that offer basic protection and AGENT are often used when the amount of exposure to fluids is relatively small and for a short period of time. Materials CROSS REFERENCE TO RELATED having an AAMI Level 3 classification require a hydrostatic APPLICATION pressure of at least 50 cm HO for water to penetrate through the material. Examples of materials typically having an 0001. This application claims the benefit of U.S. Provi AAMI Level 3 classification include articles that offer sional Application Ser. No. 61/799,443, filed on Mar. 15, increased barrier protection and are often used when the 2013, which is expressly incorporated by reference herein in amount of fluid exposure is moderate. Materials having an its entirety. AAMI Level 4 classification are impervious to water passing FIELD OF THE INVENTION through. 0006 Surgical drapes and gowns often have an AAMI 0002 The present invention is directed to medical articles Level 4 classification. Isolation gowns may have an AAMI having improved antimicrobial efficacy. level 1, 2, 3, or 4 rating. Surgical gowns typically have an AAMI level 3 or 4 rating and they typically include a fluoro BACKGROUND OF THE INVENTION carbon treatment to impart alcohol repellency. Many Surgical 0003. In the United States, hospital-acquired infections, drapes are made of SMS fabric that is not completely imper also known as nosocomial infections, cause or contribute to vious across the entire drape area. Typically, the non-rein almost 100,000 deaths each year. Disposable medical forced SMS portion of the surgical drape is alcohol and fluid articles, such as gowns, drapes, shoe covers, wraps, and caps repellant and has a hydrostatic pressure of at least 50 centi are regularly used to minimize the transmission of such infec meters of HO, Surgical drapes are generally rated AAMI tions. These articles are often worn or used for a short period level 4 in the reinforced critical Zone surrounding the Surgical of time, for example less than ten minutes. This is especially site. The drape critical Zone typically has a liquid impervious true with isolation gowns, which are typically worn in inten absorbent reinforcement adhered to the SMS drape body sive care units, or worn by clinicians caring for patients with fabric. The impervious reinforcement often comprises a non compromised immune systems. Isolation gowns worn by cli woven/filmbilaminate, where the reinforcement nonwovenis nicians are typically changed after visiting each patient. Visi treated to make it absorbent. tors of patients having compromised immune Systems also 0007 Some nonwoven materials are coated with an anti frequently wear isolation gowns. Isolation and Surgical microbial material to kill microbes that contact the surface of gowns are used primarily for three purposes in the relevant the articles. Antimicrobial activity is measured by determin art. First, the gowns protect the clinician from the transfer of ing the log reduction of infectious bacterial counts after expo infectious organisms from the patient to the clinician by form Sure to an antimicrobial Substance. For example, a 3-log ing a physical barrier between the patient and the clinician. reduction refers to a 99.9% reduction, and a 4-log reduction Second, the gowns prevent the transfer of infectious micro refers to a 99.99% reduction. However, antimicrobial coat organisms from the clinician to the patient. Third, the gowns ings known in the art are not as fast acting as desired. prevent the transfer of organisms from the hospital environ 0008. There is a need in the art for nonwoven materials ment and/or from other patients to the clinician then from the which have fast-acting antimicrobial activity. Preferably, the clinician to another patient. medical articles are able to kill a high number of microbes, 0004. Many of these articles are made with nonwoven such as a 2, 3 or 4 log reduction (99% to 99.99%), within a materials or fabrics, such as spunbond/meltblown/spunbond short period of time, such as fewer than 5 or 10 minutes. Such (SMS) laminates of polypropylene fibers and can form bar a material would help reduce the transmission of hospital riers against microbes and/or fluids. The ability to block the acquired infections, as the “quick kill of microbes could penetration of fluids, such as bodily fluids, is important in a break the chain of infection from one surface to another. medical environment. Some medical articles, such as medical 0009 Huang, Wei and Leonas, Karen, Evaluating a One gowns, are classified into levels of barrier performance based Bath Process for Imparting Antimicrobial Activity and Repel on the AAMI/ANSI PB70 standard, which is a standard lency to Nonwoven Surgical Gown Fabrics, Textile Res. J. developed by the Association for the Advancement of Medi 70(9), 774-782 (2000), relates to nonwoven fabrics having cal Instrumentation and approved by the American National various add-on levels of antimicrobial finish and fluoro Standards Institute. In the AAMI/ANSI PB70 standard, the chemical finish. Huang examined ZONYL(R) 8300 from Ciba key test for measuring the barrier performance of a material is Specialty Chemical Corporation as the fluorochemical finish the Water Resistance: Hydrostatic Pressure Test, AATCC Test and polyhexamethylene biguanide (PHMB) as the antimicro Method 127, which was established by the American Asso bial finish. The antimicrobial efficacy was tested after 24 ciation of Textile Chemists and Colorists. The hydrostatic hours of incubation. Huang found that the effectiveness of the pressure test measures the resistance of a material to the antimicrobial finish was not influenced by the level of the penetration of water under increasing pressure. fluorochemical finish. 0005. There are four levels of barrier performance accord 00.10 EP 1943302 is directed to a material substrate hav ing to the AAMI/ANSI PB70 standard. Materials having an ing at least part of a surface treated with an antimicrobial AAMI Level 1 classification pass a spray impact test and are composition is described. The antimicrobial composition effective for impact penetration. Examples of materials typi exhibits at least a 3 log 10 CFU reduction within a period of cally having an AAMI Level 1 classification include basic about 30 minutes after contact with various species of a broad cover gowns and some isolation gowns. Materials having an spectrum of microorganisms. The Substrate can be a non AAMI Level 2 classification require a hydrostatic pressure of woven material that has good fluid barrier properties, which at least 20 cm H2O for water to penetrate through the material. can be used in protective garments and sheets. Methods for US 2014/0273689 A1 Sep. 18, 2014 manufacturing and imparting the antimicrobial treatment to nium chloride (BKC)), benzethonium (e.g., benzethonium the substrate are also provided. chloride (BEC), octenidine (e.g., octenidine dihydrochlo 0011 All references cited herein are incorporated by ref ride), cetrimonium (e.g., cetrimonium bromide or cetrimo erence in their entirety. nium chloride), cetylpyridinium (e.g., cetylpyridinium chlo ride), benzoxonium (e.g., benzoxonium chloride), SUMMARY OF THE INVENTION didecyldimethylammonium (e.g., didecyldimethylammo nium chloride), and dodeclonium (e.g., dodeclonium bro 0012. The present invention is directed to an article com mide). Example biguanides include polyhexamethylene prising, a nonwoven material, and a coating contacting the biguanide (PHMB), free base chlorhexidine and chlorhexi nonwoven material. The coating comprising at least one fluo dine salts. Example chlorhexidine salts include chlorhexidine rochemical and at least one antimicrobial agent. The fluoro gluconate (CHG)
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