Mycobacterium tuberculosis H37Rv Chromosome

by Carol A Fulcher1, Ron Caspi1, Markus Krummenacker1, Suzanne Paley1, Anamika Kothari1, Maneesh Yadav1, Ingrid Keseler1, Peter D Karp1, Amanda Mackie2 --- 1SRI International, 2Macquarie University Legend: Protein gene Transcription Start Adjacent genes drawn in the same color are within the same operon.

Copyright 2018, SRI International. All Rights Reserved. RNA gene Terminator Uncolored genes are not yet assigned to an operon. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors M. Krummenacker and P.D. Karp. Pseudo-genes are crossed out with a big, diagonal X.

Rv0027 Rv0028 Rv0030 Rv0031 Rv0039c dnaA dnaN recF Rv0004 gyrB gyrA Rv0007 Rv0008c ppiA Rv0010c crgA Rv0012 trpG pknB pknA pbpA rodA pstP fhaB fhaA Rv0021c whiB5 Rv0023 Rv0024 Rv0025 Rv0026 Rv0029 bioF2 acpA Rv0034 fadD34 Rv0036c Rv0037c Rv0038 mtc28 leuS : probable leucyl-tRNA synthetase Rv0042c Rv0043c Rv0044c Rv0045c ino1 Rv0047c Rv0048c Rv0049 ponA1 Rv0051

2,000 4,000 6,000 8,000 10,000 12,000 14,000 16,000 18,000 20,000 22,000 24,000 26,000 28,000 30,000 32,000 34,000 36,000 38,000 40,000 42,000 44,000 46,000 48,000 50,000 52,000 54,000 56,000 rpsR1 Rv0061c vapB1 Rv0076c Rv0081 Rv0100 Rv0052 rpsF ssb rplI Rv0057 dnaB : probable replicative DNA helicase Rv0059 Rv0060 celA1 Rv0063 Rv0064 : probable conserved transmembrane protein vapC1 icd2 Rv0067c Rv0068 sdaA glyA2 Rv0071 Rv0072 Rv0073 Rv0074 Rv0075 ethA2 Rv0078 Rv0078A Rv0079 Rv0080 Rv0082 Rv0083 : uncharacterized protein hycD hycP hycQ hycE Rv0088 Rv0089 Rv0090 mtn ctpA Rv0093c Rv0094c Rv0095c PPE1 Rv0097 fcoT fadD10 nrp : probable peptide synthetase

58,000 60,000 62,000 64,000 66,000 68,000 70,000 72,000 74,000 76,000 78,000 80,000 82,000 84,000 86,000 88,000 90,000 92,000 94,000 96,000 98,000 100,000 102,000 104,000 106,000 108,000 110,000 112,000 114,000 rpmB1 nrp : probable peptide synthetase Rv0102 ctpB Rv0104 Rv0106 ctpI : probable cation-transporter ATPase I PE_PGRS1 Rv0110 Rv0111 gca gmhA gmhB hddA ldtA oxyS oxcA fadD7 fusA2 : probable elongation factor G Rv0121c Rv0122 Rv0123 PE_PGRS2 pepA treS : trehalose synthase mak : maltokinase Rv0128 fbpC htdZ fadE1 fgd2 Rv0133 ephF Rv0135c cyp138 msrA Rv0138 Rv0139 Rv0140 Rv0141c Rv0142 Rv0143c Rv0144 Rv0145

116,000 118,000 120,000 122,000 124,000 126,000 128,000 130,000 132,000 134,000 136,000 138,000 140,000 142,000 144,000 146,000 148,000 150,000 152,000 154,000 156,000 158,000 160,000 162,000 164,000 166,000 168,000 170,000 Rv0145 Rv0150c mymT Rv0192A Rv0146 Rv0147 Rv0148 Rv0149 PE1 : PE family protein PE1 PE2 : PE family protein PE2 ptbB fadE2 pntAa pntAb pntB Rv0158 PE3 PE4 Rv0161 adhE1 Rv0163 TB18.5 mce1R fadD5 yrbE1A yrbE1B mce1A mce1B mce1C mce1D lprK mce1F Rv0175 Rv0176 Rv0177 Rv0178 lprO Rv0180c Rv0181c sigG Rv0183 Rv0184 Rv0185 bglS : probable beta-glucosidase Rv0187 Rv0188 ilvD ricR Rv0191 Rv0192 Rv0193c : hypothetical protein Rv0194

172,000 174,000 176,000 178,000 180,000 182,000 184,000 186,000 188,000 190,000 192,000 194,000 196,000 198,000 200,000 202,000 204,000 206,000 208,000 210,000 212,000 214,000 216,000 218,000 220,000 222,000 224,000 226,000 228,000

Rv0194 Rv0195 Rv0196 Rv0197 : possible oxidoreductase zmp1 Rv0199 Rv0200 Rv0201c mmpL11 Rv0203 Rv0204c Rv0205 mmpL3 : mycobacterial membrane protein L3 Rv0207c Rv0208c Rv0209 Rv0210 pckA nadR Rv0213c fadD4 fadE3 Rv0216 lipW Rv0218 Rv0219 lipC Rv0221 echA1 Rv0223c Rv0224c Rv0225 Rv0226c Rv0227c Rv0228 Rv0229c php fadE4 Rv0232 nrdB gabD1 Rv0235c aftD : possible arabinofuranosyltransferase

230,000 232,000 234,000 236,000 238,000 240,000 242,000 244,000 246,000 248,000 250,000 252,000 254,000 256,000 258,000 260,000 262,000 264,000 266,000 268,000 270,000 272,000 274,000 276,000 278,000 280,000 282,000 284,000 286,000 vapB24 F6 Rv0250c vapB25 aftD lpqI Rv0238 vapC24 htdX fabG4 fadA2 fadE5 : acyl-CoA dehydrogenase Rv0245 Rv0246 Rv0247c Rv0248c Rv0249c hsp nirB nirD cobU cobQ1 PPE2 Rv0257 Rv0258c Rv0259c Rv0260c narK3 aac Rv0263c Rv0264c Rv0265c oplA : probable 5-oxoprolinase narU Rv0268c Rv0269c fadD2 fadE6 Rv0272c Rv0273c Rv0274 Rv0275c Rv0276 vapC25 PE_PGRS3 : PE-PGRS family protein PE_PGRS3 PE_PGRS4 : PE-PGRS family protein PE_PGRS4 PPE3 Rv0281 eccA3

288,000 290,000 292,000 294,000 296,000 298,000 300,000 302,000 304,000 306,000 308,000 310,000 312,000 314,000 316,000 318,000 320,000 322,000 324,000 326,000 328,000 330,000 332,000 334,000 336,000 338,000 340,000 342,000 eccA3 Rv0298Rv0299 vapB2 Rv0325 eccB3 eccC3 PE5 PPE4 esxG esxH espG3 eccD3 mycP3 : mycosin-3 eccE3 Rv0293c tam Rv0295c Rv0296c PE_PGRS5 vapC2 Rv0302 Rv0303 PPE5 : PPE family protein PPE5 PPE6 : PPE family protein PPE6 Rv0306 Rv0307c Rv0308 Rv0309 Rv0310c Rv0311 Rv0312 Rv0313 Rv0314c Rv0315 Rv0316 glpQ2 Rv0318c pcp Rv0320 dcd udgA Rv0323c Rv0324 Rv0326 cyp135A1 Rv0328 Rv0329c Rv0330c Rv0331 Rv0332 Rv0333 rmlA PE6 Rv0336

344,000 346,000 348,000 350,000 352,000 354,000 356,000 358,000 360,000 362,000 364,000 366,000 368,000 370,000 372,000 374,000 376,000 378,000 380,000 382,000 384,000 386,000 388,000 390,000 392,000 394,000 396,000 398,000 400,000 Rv0367c Rv0378 secE2 Rv0336 aspC Rv0338c Rv0339c Rv0340 iniB iniA iniC lpqJ Rv0345 ansP2 Rv0347 Rv0348 Rv0349 dnaK : probable chaperone protein grpE dnaJ1 hspR PPE7 PPE8 : PPE family protein PPE8 Rv0356c purA Rv0358 Rv0359 Rv0360c Rv0361 mgtE fba Rv0364 Rv0365c Rv0366c Rv0368c Rv0369c Rv0370c Rv0371c Rv0372c Rv0373c Rv0374c Rv0375c Rv0376c Rv0377 Rv0380c Rv0381c pyrE

402,000 404,000 406,000 408,000 410,000 412,000 414,000 416,000 418,000 420,000 422,000 424,000 426,000 428,000 430,000 432,000 434,000 436,000 438,000 440,000 442,000 444,000 446,000 448,000 450,000 452,000 454,000 456,000 458,000 Rv0397A thiS Rv0424c Rv0426c ttfA clpB Rv0385 Rv0386 Rv0387c PPE9 purT Rv0390 metZ ndhA Rv0393 Rv0394c Rv0395 Rv0396 Rv0397 Rv0398c lpqK fadE7 Rv0401 mmpL1 mmpS1 fadD30 : fatty-acid-AMP ligase pks6 : probable membrane bound polyketide synthase Rv0406c fgd1 pta ackA pknG : serine/threonine-protein kinase glnH Rv0412c mutT3 thiE thiO thiG lpqL lpqM Rv0420c Rv0421c thiD thiC ctpH : possible metal cation transporting P-type ATPase

460,000 462,000 464,000 466,000 468,000 470,000 472,000 474,000 476,000 478,000 480,000 482,000 484,000 486,000 488,000 490,000 492,000 494,000 496,000 498,000 500,000 502,000 504,000 506,000 508,000 510,000 512,000 514,000 Rv0430 mazF1mazE1 Rv0460 Rv0463 Rv0476 xthA Rv0428c def Rv0431 sodC Rv0433 Rv0434 Rv0435c : putative conserved ATPase pssA psd moeA2 Rv0439c groEL2 : 60 kDa chaperonin 2 Rv0441c PPE10 Rv0443 rskA sigK Rv0446c ufaA1 Rv0448c Rv0449c mmpL4 mmpS4 Rv0452 PPE11 Rv0454 Rv0455c echA2 Rv0457c : probable peptidase Rv0458 Rv0459 Rv0461 lpdC Rv0464c Rv0465c Rv0466 icl1 fadB2 umaA pcaA Rv0470A Rv0471c Rv0472c Rv0473 Rv0474 hbhA Rv0477 deoC Rv0479c Rv0480c Rv0481c murB lprQ

516,000 518,000 520,000 522,000 524,000 526,000 528,000 530,000 532,000 534,000 536,000 538,000 540,000 542,000 544,000 546,000 548,000 550,000 552,000 554,000 556,000 558,000 560,000 562,000 564,000 566,000 568,000 570,000 572,000 Rv0492A Rv0500A Rv0508 Rv0514 Rv0521 Rv0523c Rv0531 fabH Rv0538 Rv0484c Rv0485 mshA Rv0487 Rv0488 gpmA senX3 regX3 Rv0492c Rv0493c Rv0494 Rv0495c ppx1 Rv0497 Rv0498 Rv0499 proC galE2 Rv0502 cmaA2 Rv0504c serB1 mmpS2 mmpL2 hemA hemC hemD hemB Rv0513 Rv0515 Rv0516c Rv0517 Rv0518 Rv0519c Rv0520 gabP hemL Rv0525 Rv0526 ccdA Rv0528 ccsA Rv0530 PE_PGRS6 menA pnp galE3 Rv0537c

574,000 576,000 578,000 580,000 582,000 584,000 586,000 588,000 590,000 592,000 594,000 596,000 598,000 600,000 602,000 604,000 606,000 608,000 610,000 612,000 614,000 616,000 618,000 620,000 622,000 624,000 626,000 628,000 630,000 Rv0543c Rv0544c Rv0546c vapB3 Rv0559c Rv0569 Rv0572c vapB26 Rv0538 Rv0539 Rv0540 Rv0541c menE pitA Rv0547c menB vapC3 fadD8 Rv0552 : conserved protein menC bpoC menD Rv0556 mgtA menH htmA menJ grcC1 htpX gpdA1 Rv0565c Rv0566c Rv0567 cyp135B1 nrdZ Rv0571c pncB2 Rv0574c Rv0575c Rv0576 cfp32 PE_PGRS7 : PE-PGRS family protein PE_PGRS7 Rv0579 Rv0580c vapC26 lpqN Rv0584 : possible conserved exported protein Rv0585c mce2R yrbE2A yrbE2B mce2A

632,000 634,000 636,000 638,000 640,000 642,000 644,000 646,000 648,000 650,000 652,000 654,000 656,000 658,000 660,000 662,000 664,000 666,000 668,000 670,000 672,000 674,000 676,000 678,000 680,000 682,000 684,000 686,000 Rv0590A vapB4 vapB27 Rv0603 vapB28 Rv0609A Rv0611c Rv0614 Rv0615Rv0616cvapB29 vapB30 vapB5 Rv0634A mce2A mce2B mce2C mce2D lprL mce2F vapC4 Rv0597c vapC27 Rv0600c Rv0601c tcrA lpqO Rv0605 Rv0606 Rv0607 vapC28 Rv0610c Rv0612 Rv0613c : unknown protein vapC29 galTa galTb galK Rv0621 Rv0622 vapC30 Rv0625c vapC5 Rv0628c recD recB recC echA3 Rv0633c Rv0634c hadA hadB hadC secE1 nusG rplK rplA mmaA4 mmaA3 mmaA2 mmaA1 lipG Rv0647c Rv0648 : alpha-mannosidase

688,000 690,000 692,000 694,000 696,000 698,000 700,000 702,000 704,000 706,000 708,000 710,000 712,000 714,000 716,000 718,000 720,000 722,000 724,000 726,000 728,000 730,000 732,000 734,000 736,000 738,000 740,000 742,000 744,000 mazE2 vapB7 vapB8 Rv0680c Rv0689c Rv0699 Rv0648 : alpha-mannosidase fabD2 Rv0650 rplJ rplL Rv0653c Rv0654 mkl vapC6 Rv0658c mazF2 vapC7 atsD : possible arylsulfatase vapC8 rpoB : DNA-directed RNA polymerase (beta chain) rpoC : DNA-directed RNA polymerase (beta' chain) Rv0669c : possible hydrolase end lpqP fadE8 echA4 Rv0674 echA5 mmpL5 mmpS5 mmpR5 Rv0679c Rv0681 rpsL rpsG fusA1 : probable elongation factor G tuf Rv0686 Rv0687 Rv0688 Rv0690c Rv0691c mftB mftC mftD mftE mftF Rv0697 Rv0698 rpsJ rplC rplD

746,000 748,000 750,000 752,000 754,000 756,000 758,000 760,000 762,000 764,000 766,000 768,000 770,000 772,000 774,000 776,000 778,000 780,000 782,000 784,000 786,000 788,000 790,000 792,000 794,000 796,000 798,000 800,000 802,000 rpsN1 rpmD Rv0724A Rv0741 vapB31 Rv0750 Rv0759c Rv0763c rplW rplB rpsS rplV rpsC rplP rpmC rpsQ atsA : possible arylsulfatase Rv0712 Rv0713 rplN rplX rplE rpsH rplF rplR rpsE rplO sppA : possible protease IV Rv0725c Rv0726c fucA serA2 xylB Rv0730 Rv0731c secY adk mapA sigL rslA Rv0737 Rv0738 Rv0739 Rv0740 PE_PGRS8 Rv0743c Rv0744c Rv0745 PE_PGRS9 PE_PGRS10 vapC31 mmsB fadE9 mmsA PE_PGRS11 PPE12 : PPE family protein PPE12 Rv0756c phoP phoR Rv0760c adhB Rv0762c cyp51 Rv0765c cyp123

804,000 806,000 808,000 810,000 812,000 814,000 816,000 818,000 820,000 822,000 824,000 826,000 828,000 830,000 832,000 834,000 836,000 838,000 840,000 842,000 844,000 846,000 848,000 850,000 852,000 854,000 856,000 858,000 ptrBa Rv0786c Rv0787A Rv0793 Rv0795 Rv0801 Rv0823c cyp123 Rv0767c aldA Rv0769 Rv0770 Rv0771 purD ggtA Rv0774c Rv0775 Rv0776c purB cyp126 Rv0779c purC ptrBb : probable protease II emrB Rv0784 Rv0785 Rv0787 purQ Rv0789c Rv0790c Rv0791c Rv0792c Rv0794c Rv0796 Rv0797 cfp29 Rv0799c pepC Rv0802c purL Rv0804 Rv0805 cpsY Rv0807 purF purM Rv0811c Rv0812 Rv0813c sseC2 cysA2 thiX Rv0817c Rv0818 mshD phoT phoY2 Rv0822c : conserved protein

860,000 862,000 864,000 866,000 868,000 870,000 872,000 874,000 876,000 878,000 880,000 882,000 884,000 886,000 888,000 890,000 892,000 894,000 896,000 898,000 900,000 902,000 904,000 906,000 908,000 910,000 912,000 914,000 916,000 ASdes Rv0829 PE_PGRS12 Rv0841 Rv0850 Rv0863 moaD2 Rv0870c Rv0823c desA1 Rv0825c Rv0826 kmtR Rv0828c Rv0830 Rv0831c PE_PGRS13 PE_PGRS14 : PE-PGRS family protein PE_PGRS14 lpqQ Rv0836c Rv0837c lpqR Rv0839 pip Rv0842 Rv0843 narL Rv0845 mmcO : multicopper oxidase lpqS cysK2 Rv0849 Rv0851c fadD16 pdc Rv0854 far Rv0856 Rv0857 dapC fadA fadB : 3-hydroxybutyryl-CoA epimerase ercc3 : DNA helicase Rv0862c : conserved protein moaC2 mog moaE2 rpfA moaA2 cspB PE_PGRS15 fadE10 Rv0874c

918,000 920,000 922,000 924,000 926,000 928,000 930,000 932,000 934,000 936,000 938,000 940,000 942,000 944,000 946,000 948,000 950,000 952,000 954,000 956,000 958,000 960,000 962,000 964,000 966,000 968,000 970,000 972,000 Rv0875c Rv0879c Rv0882 Rv0898c Rv0876c Rv0877 PPE13 Rv0880 Rv0881 Rv0883c serC Rv0885 fprB Rv0887c spmT citA Rv0890c Rv0891c Rv0892 Rv0893c Rv0894 Rv0895 gltA2 Rv0897c ompA Rv0901 prrB prrA accD3 echA6 Rv0906 Rv0907 : conserved protein ctpE Rv0910 Rv0911 Rv0912 Rv0913c Rv0914c PPE14 PE7 betP Rv0918 Rv0919 Rv0920c Rv0921 Rv0922 : possible transposase Rv0923c mntH

974,000 976,000 978,000 980,000 982,000 984,000 986,000 988,000 990,000 992,000 994,000 996,000 998,000 1,000,000 1,002,000 1,004,000 1,006,000 1,008,000 1,010,000 1,012,000 1,014,000 1,016,000 1,018,000 1,020,000 1,022,000 1,024,000 1,026,000 1,028,000 1,030,000 Rv0942 Rv0947c Rv0948c vapB9 Rv0961 Rv0968 mntH Rv0925c Rv0926c Rv0927c pstS3 pstC2 pstA1 pknD pstS2 pstB pstS1 pstC1 pstA2 mku ligD : ATP dependent DNA ligase Rv0939 Rv0940c Rv0941c Rv0943c Rv0944 Rv0945 pgi uvrD1 Rv0950c sucC sucD Rv0953c Rv0954 Rv0955 purN purH Rv0958 Rv0959 vapC9 lprP Rv0963c Rv0964c Rv0965c Rv0966c csoR ctpV Rv0970 echA7 fadE12 accA2 accD2 fadE13

1,032,000 1,034,000 1,036,000 1,038,000 1,040,000 1,042,000 1,044,000 1,046,000 1,048,000 1,050,000 1,052,000 1,054,000 1,056,000 1,058,000 1,060,000 1,062,000 1,064,000 1,066,000 1,068,000 1,070,000 1,072,000 1,074,000 1,076,000 1,078,000 1,080,000 1,082,000 1,084,000 1,086,000 1,088,000 rpmF Rv0991c Rv1012 Rv0976c PE_PGRS16 : PE-PGRS family protein PE_PGRS16 PE_PGRS17 PE_PGRS18 mprA mprB pepD moaB2 mscL Rv0986 Rv0987 Rv0988 grcC2 hsp22.5 Rv0992c galU moeA1 rimJ Rv0996 Rv0997 Rv0998 Rv0999 Rv1000c arcA Rv1002c rsmI Rv1004c pabB Rv1006 : unknown protein metS tatD rpfB ksgA ispE pks16 pth rplY lpqT prsA glmU Rv1019 mfd : probable transcription-repair coupling factor mazG lpqU eno

1,090,000 1,092,000 1,094,000 1,096,000 1,098,000 1,100,000 1,102,000 1,104,000 1,106,000 1,108,000 1,110,000 1,112,000 1,114,000 1,116,000 1,118,000 1,120,000 1,122,000 1,124,000 1,126,000 1,128,000 1,130,000 1,132,000 1,134,000 1,136,000 1,138,000 1,140,000 1,142,000 1,144,000 Rv1034c Rv1036c Rv1042c Rv1053c Rv1054 Rv1024 Rv1025 ppx2 kdpE kdpD : probable sensor protein kdpA kdpB kdpC trcS trcR Rv1035c esxI esxJ PPE15 PE8 Rv1041c Rv1043c Rv1044 Rv1045 Rv1046c Rv1047 Rv1048c Rv1049 Rv1050 Rv1051c Rv1052 Rv1056 Rv1057 fadD14 Rv1059 Rv1060 Rv1061 Rv1062 Rv1063c lpqV Rv1065 Rv1066 PE_PGRS19 PE_PGRS20 Rv1069c : conserved protein echA8 echA9 Rv1072 Rv1073 fadA3 Rv1075c lipU cbs

1,146,000 1,148,000 1,150,000 1,152,000 1,154,000 1,156,000 1,158,000 1,160,000 1,162,000 1,164,000 1,166,000 1,168,000 1,170,000 1,172,000 1,174,000 1,176,000 1,178,000 1,180,000 1,182,000 1,184,000 1,186,000 1,188,000 1,190,000 1,192,000 1,194,000 1,196,000 1,198,000 1,200,000 1,202,000 Rv1083 Rv1087A PE10 vapB32 Rv1116A Rv1117 pra metB greA Rv1081c mca Rv1084 : conserved protein Rv1085c Rv1086 PE_PGRS21 PE9 celA2b PE_PGRS22 : PE-PGRS family protein PE_PGRS22 coaA glyA1 desA2 phoH2 Rv1096 Rv1097c fum : fumarase glpX Rv1100 Rv1101c mazF3 mazE3 Rv1104 Rv1105 Rv1106c xseB xseA Rv1109c lytB2 Rv1111c Rv1112 vapC32 Rv1115 Rv1118c Rv1120c zwf1 gnd2 bpoB ephC Rv1125 Rv1126c ppdK Rv1128c prpR prpD prpC Rv1132 metE

1,204,000 1,206,000 1,208,000 1,210,000 1,212,000 1,214,000 1,216,000 1,218,000 1,220,000 1,222,000 1,224,000 1,226,000 1,228,000 1,230,000 1,232,000 1,234,000 1,236,000 1,238,000 1,240,000 1,242,000 1,244,000 1,246,000 1,248,000 1,250,000 1,252,000 1,254,000 1,256,000 1,258,000 1,260,000 Rv1134 Rv1135A Rv1136 Rv1137c Rv1150 Rv1159.1 metE PPE16 : PPE family protein PPE16 Rv1138c Rv1139c Rv1140 echA11 echA10 mcr Rv1144 mmpL13a mmpL13b Rv1147 Rv1148c Rv1149 Rv1151c Rv1152 omt Rv1154c Rv1155 Rv1156 Rv1157c Rv1158c pimE mutT2 narG narH narJ narI typA lpqW Rv1167c PPE17 lipX mshB Rv1171 PE12 fbiC TB8.4 fadH Rv1176c fdxC Rv1178 Rv1179c : unknown protein pks3 pks4

1,262,000 1,264,000 1,266,000 1,268,000 1,270,000 1,272,000 1,274,000 1,276,000 1,278,000 1,280,000 1,282,000 1,284,000 1,286,000 1,288,000 1,290,000 1,292,000 1,294,000 1,296,000 1,298,000 1,300,000 1,302,000 1,304,000 1,306,000 1,308,000 1,310,000 1,312,000 1,314,000 1,316,000 Rv1211 pks4 papA3 mmpL10 Rv1184c fadD21 Rv1186c Rv1187 Rv1188 sigI Rv1190 Rv1191 Rv1192 fadD36 Rv1194c PE13 PPE18 esxK esxL Rv1199c Rv1200 dapD dapE Rv1203c Rv1204c log fadD6 folP2 gpgS Rv1209 tagA glgA glgC PE14 Rv1215c : conserved protein Rv1216c Rv1217c Rv1218c Rv1219c Rv1220c sigE rseA htrA tatB Rv1225c Rv1226c Rv1227c lpqX mrp Rv1230c Rv1231c

1,318,000 1,320,000 1,322,000 1,324,000 1,326,000 1,328,000 1,330,000 1,332,000 1,334,000 1,336,000 1,338,000 1,340,000 1,342,000 1,344,000 1,346,000 1,348,000 1,350,000 1,352,000 1,354,000 1,356,000 1,358,000 1,360,000 1,362,000 1,364,000 1,366,000 1,368,000 1,370,000 1,372,000 1,374,000 vapB33 Rv1250 Rv1269c Rv1271c Rv1232c Rv1233c Rv1234 lpqY sugA sugB sugC corA mdh vapC33 PE_PGRS23 lpqZ Rv1245c relE relB Rv1248c : 2-hydroxy-3-oxoadipate synthase Rv1249c Rv1251c : conserved hypothetical protein lprE deaD Rv1254 Rv1255c cyp130 Rv1257c Rv1258c udgB Rv1260 Rv1261c Rv1262c amiB2 : probable amidase Rv1264 Rv1265 pknH embR Rv1268c lprA Rv1272c Rv1273c lprB lprC Rv1276c Rv1277 Rv1278 : hypothetical protein Rv1279 oppA

1,376,000 1,378,000 1,380,000 1,382,000 1,384,000 1,386,000 1,388,000 1,390,000 1,392,000 1,394,000 1,396,000 1,398,000 1,400,000 1,402,000 1,404,000 1,406,000 1,408,000 1,410,000 1,412,000 1,414,000 1,416,000 1,418,000 1,420,000 1,422,000 1,424,000 1,426,000 1,428,000 1,430,000 1,432,000 Rv1290A Rv1291c Rv1322 oppA oppD oppC oppB canA cysD cysN Rv1287 Rv1288 Rv1289 Rv1290c : conserved protein argS lysA thrA thrC thrB rho rpmE prfA hemK : probable Rv1301 wecA Rv1303 atpB atpE atpF atpH atpA atpG atpD atpC Rv1312 Rv1313c Rv1314c murA rrs : Ribosomal RNA 16S rrl : Ribosomal RNA 23S ogt alkA Rv1318c Rv1319c Rv1320c nucS Rv1322A fadA4 Rv1324 PE_PGRS24

1,434,000 1,436,000 1,438,000 1,440,000 1,442,000 1,444,000 1,446,000 1,448,000 1,450,000 1,452,000 1,454,000 1,456,000 1,458,000 1,460,000 1,462,000 1,464,000 1,466,000 1,468,000 1,470,000 1,472,000 1,474,000 1,476,000 1,478,000 1,480,000 1,482,000 1,484,000 1,486,000 1,488,000 PE_PGRS24 Rv1342c Rv1351 Rv1366A Rv1370c glgB glgE glgP : probable glycogen phosphorylase dinG pncB1 clpS Rv1332 Rv1333 mec cysO cysM Rv1337 murI Rv1339 rphA : RphA Rv1341 lprD mbtL mbtM mbtN mbtK irtA irtB fabG2 Rv1352 Rv1353c Rv1354c moeY Rv1356c Rv1357c Rv1358 : probable transcriptional regulatory protein Rv1359 Rv1360 PPE19 Rv1362c Rv1363c mcr15 Rv1364c rsfA Rv1366 Rv1367c lprF Rv1369c Rv1371 pks18 Rv1373

1,490,000 1,492,000 1,494,000 1,496,000 1,498,000 1,500,000 1,502,000 1,504,000 1,506,000 1,508,000 1,510,000 1,512,000 1,514,000 1,516,000 1,518,000 1,520,000 1,522,000 1,524,000 1,526,000 1,528,000 1,530,000 1,532,000 1,534,000 1,536,000 1,538,000 1,540,000 1,542,000 1,544,000 1,546,000 vapB10 Rv1428c Rv1374c Rv1375 Rv1376 Rv1377c Rv1378c pyrR pyrB pyrC Rv1382 carA carB pyrF PE15 PPE20 mihF gmk rpoZ dfp metK Rv1393c cyp132 Rv1395 PE_PGRS25 vapC10 nlhH lipI Rv1401 priA Rv1403c Rv1404 Rv1405c fmt fmu : probable rpe ribG Rv1410c lprG ribC Rv1413 Rv1414 ribA2 ribH Rv1417 lprH Rv1419 uvrC Rv1421 Rv1422 whiA Rv1424c Rv1425 lipO fadD12

1,548,000 1,550,000 1,552,000 1,554,000 1,556,000 1,558,000 1,560,000 1,562,000 1,564,000 1,566,000 1,568,000 1,570,000 1,572,000 1,574,000 1,576,000 1,578,000 1,580,000 1,582,000 1,584,000 1,586,000 1,588,000 1,590,000 1,592,000 1,594,000 1,596,000 1,598,000 1,600,000 1,602,000 1,604,000

Rv1428c Rv1429 PE16 Rv1431 Rv1432 Rv1433 Rv1435c gap pgk tpi Rv1439c secG PE_PGRS26 bisC Rv1443c Rv1444c devB opcA zwf2 tal tkt : transketolase PE_PGRS27 : PE-PGRS family protein PE_PGRS27 ctaB PE_PGRS28 Rv1453 qor Rv1455 Rv1456c Rv1457c Rv1458c Rv1459c sufR Rv1461 : Endonuclease PI-MtuHIIP Rv1462 Rv1463 csd Rv1465 Rv1466 fadE15 Rv1468c ctpD trxA trxB1 echA12 Rv1473

1,606,000 1,608,000 1,610,000 1,612,000 1,614,000 1,616,000 1,618,000 1,620,000 1,622,000 1,624,000 1,626,000 1,628,000 1,630,000 1,632,000 1,634,000 1,636,000 1,638,000 1,640,000 1,642,000 1,644,000 1,646,000 1,648,000 1,650,000 1,652,000 1,654,000 1,656,000 1,658,000 1,660,000 Rv1489A Rv1498A Rv1508A Rv1519 Rv1473 Rv1474c acn : aconitase Rv1476 ripA Rv1478 moxR1 Rv1480 Rv1481 Rv1482c fabG1 inhA hemZ Rv1486c Rv1487 Rv1488 Rv1489 Rv1490 Rv1491c mutA mutB mazE4 mazF4 Rv1496 lipL Rv1498c Rv1499 Rv1500 Rv1501 Rv1502 Rv1503c Rv1504c Rv1505c Rv1506c Rv1507c Rv1507A Rv1508c Rv1509 Rv1510 gmdA epiA Rv1513 Rv1514c Rv1515c Rv1516c Rv1517 Rv1518 Rv1520 fadD25 mmpL12 : probable conserved transmembrane transport protein Rv1523

1,662,000 1,664,000 1,666,000 1,668,000 1,670,000 1,672,000 1,674,000 1,676,000 1,678,000 1,680,000 1,682,000 1,684,000 1,686,000 1,688,000 1,690,000 1,692,000 1,694,000 1,696,000 1,698,000 1,700,000 1,702,000 1,704,000 1,706,000 1,708,000 1,710,000 1,712,000 1,714,000 1,716,000 1,718,000 Rv1535 Rv1545 fadD11.1 vapB11 Rv1567c Rv1524 wbbL2 Rv1526c pks5 : probable polyketide synthase papA4 fadD24 adh Rv1531 Rv1532c Rv1533 Rv1534 ileS : isoleucyl-tRNA synthetase dinX ansA lspA Rv1540 lprI glbN Rv1543 Rv1544 Rv1546 dnaE1 : probable DNA polymerase III (alpha chain) PPE21 : PPE family protein PPE21 fadD11 plsB1 : possible acyltransferase frdA frdB frdC frdD Rv1556 mmpL6 Rv1558 ilvA vapC11 treZ treY : maltooligosyltrehalose synthase treX Rv1565c Rv1566c bioA

1,720,000 1,722,000 1,724,000 1,726,000 1,728,000 1,730,000 1,732,000 1,734,000 1,736,000 1,738,000 1,740,000 1,742,000 1,744,000 1,746,000 1,748,000 1,750,000 1,752,000 1,754,000 1,756,000 1,758,000 1,760,000 1,762,000 1,764,000 1,766,000 1,768,000 1,770,000 1,772,000 1,774,000 1,776,000 Rv1574 Rv1579cRv1580c Rv1581c Rv1583cRv1584c Rv1587c Rv1590 bioA bioF1 bioD Rv1571 Rv1573 Rv1575 Rv1576c Rv1577c Rv1578c Rv1582c Rv1585c Rv1586c Rv1588c bioB Rv1591 Rv1592c Rv1593c nadA nadB nadC Rv1597 Rv1598c hisD hisC1 hisB hisH hisA impA hisF hisI chaA bcpB trpE Rv1610 trpC trpB trpA lgt Rv1615 Rv1616 pykA tesB1 Rv1619 cydC cydD cydB cydA Rv1624c cya Rv1626 Rv1627c Rv1628c polA : probable DNA polymerase I

1,778,000 1,780,000 1,782,000 1,784,000 1,786,000 1,788,000 1,790,000 1,792,000 1,794,000 1,796,000 1,798,000 1,800,000 1,802,000 1,804,000 1,806,000 1,808,000 1,810,000 1,812,000 1,814,000 1,816,000 1,818,000 1,820,000 1,822,000 1,824,000 1,826,000 1,828,000 1,830,000 1,832,000 Rv1638A rpmI rpsA coaE Rv1632c uvrB Rv1634 Rv1635c TB15.3 Rv1637c uvrA Rv1639c lysX : lysyl-tRNA synthetase 2 infC rplT tsnR Rv1645c PE17 Rv1647 Rv1648 pheS pheT PE_PGRS30 : PE-PGRS family protein PE_PGRS30 argC argJ argB argD argF argR argG argH pks10 pks7 : probable polyketide synthase pks8 : Pks8, subunit of 2-methyl-octadec-2,9-dienoate synthase pks17 pks9 : probable polyketide synthase

1,834,000 1,836,000 1,838,000 1,840,000 1,842,000 1,844,000 1,846,000 1,848,000 1,850,000 1,852,000 1,854,000 1,856,000 1,858,000 1,860,000 1,862,000 1,864,000 1,866,000 1,868,000 1,870,000 1,872,000 1,874,000 1,876,000 1,878,000 1,880,000 1,882,000 1,884,000 1,886,000 1,888,000 1,890,000 Rv1670 Rv1684 vapB12 pks9 pks11 cyp139 Rv1667c Rv1668c Rv1669 Rv1671 Rv1672c Rv1673c Rv1674c cmr Rv1676 dsbF Rv1678 fadE16 Rv1680 moeX Rv1682 Rv1683 Rv1685c Rv1686c Rv1687c mpg tyrS G2 lprJ Rv1691 Rv1692 tlyA ppnK recN Rv1697 mctB pyrG : probable CTP synthase Rv1700 Rv1701 Rv1702c Rv1703c cycA PPE22 PPE23 Rv1707 Rv1708 scpA scpB Rv1711 cmk engA Rv1714 fadB3 Rv1716 Rv1717 Rv1718 Rv1719 vapC12

1,892,000 1,894,000 1,896,000 1,898,000 1,900,000 1,902,000 1,904,000 1,906,000 1,908,000 1,910,000 1,912,000 1,914,000 1,916,000 1,918,000 1,920,000 1,922,000 1,924,000 1,926,000 1,928,000 1,930,000 1,932,000 1,934,000 1,936,000 1,938,000 1,940,000 1,942,000 1,944,000 1,946,000 AS1726 Rv1734c Rv1738 vapB34vapC34 Rv1757c Rv1761c Rv1763 Rv1765A Rv1766 Rv1722 Rv1723 Rv1724c Rv1725c Rv1726 Rv1727 Rv1728c Rv1729c Rv1730c gabD2 Rv1732c Rv1733c Rv1735c narX : probable nitrate reductase narK2 Rv1739c Rv1742 pknE Rv1744c idi pknF Rv1747 : hypothetical protein Rv1747 Rv1748 Rv1749c fadD1 Rv1751 Rv1752 PPE24 : PPE family protein PPE24 Rv1754c : conserved protein plcD Rv1756c cut1 wag22 : PE-PGRS family protein Wag22 Rv1760 Rv1762c Rv1764 Rv1765c Rv1767 PE_PGRS31 Rv1769 Rv1770

1,948,000 1,950,000 1,952,000 1,954,000 1,956,000 1,958,000 1,960,000 1,962,000 1,964,000 1,966,000 1,968,000 1,970,000 1,972,000 1,974,000 1,976,000 1,978,000 1,980,000 1,982,000 1,984,000 1,986,000 1,988,000 1,990,000 1,992,000 1,994,000 1,996,000 1,998,000 2,000,000 2,002,000 2,004,000 Rv1772 Rv1786 esxM lppT Rv1804c Rv1805c Rv1771 Rv1773c Rv1774 Rv1775 Rv1776c cyp144 Rv1778c Rv1779c Rv1780 malQ eccB5 eccC5 cyp143 PPE25 PE18 PPE26 PPE27 PE19 esxN espG5 eccD5 mycP5 eccE5 eccA5 PPE28 : PPE family protein PPE28 PPE29 PPE30 PE_PGRS32 PE20 PPE31 PPE32 PPE33 Rv1810 mgtC Rv1812c Rv1813c erg3 Rv1815 Rv1816 Rv1817 PE_PGRS33

2,006,000 2,008,000 2,010,000 2,012,000 2,014,000 2,016,000 2,018,000 2,020,000 2,022,000 2,024,000 2,026,000 2,028,000 2,030,000 2,032,000 2,034,000 2,036,000 2,038,000 2,040,000 2,042,000 2,044,000 2,046,000 2,048,000 2,050,000 2,052,000 2,054,000 2,056,000 2,058,000 2,060,000 2,062,000 Rv1831 vapB13 Rv1861 bacA ilvG secA2 pgsA2 Rv1823 Rv1824 Rv1825 gcvH garA Rv1828 Rv1829 Rv1830 gcvB Rv1833c lipZ Rv1835c Rv1836c : conserved protein glcB : malate synthase G vapC13 PE_PGRS34 Rv1841c Rv1842c guaB1 gnd1 blaR blaI Rv1847 ureA ureB ureC ureF ureG ureD ndh Rv1855c Rv1856c modA modB modC apa adhA Rv1863c Rv1864c Rv1865c Rv1866 : Probable CoA-transferase Rv1866 Rv1867 : conserved protein Rv1868 Rv1869c

2,064,000 2,066,000 2,068,000 2,070,000 2,072,000 2,074,000 2,076,000 2,078,000 2,080,000 2,082,000 2,084,000 2,086,000 2,088,000 2,090,000 2,092,000 2,094,000 2,096,000 2,098,000 2,100,000 2,102,000 2,104,000 2,106,000 2,108,000 2,110,000 2,112,000 2,114,000 2,116,000 2,118,000 Rv1871c Rv1889c AS1890 Rv1892Rv1893 Rv1896c Rv1898 Rv1924c Rv1869c Rv1870c lldD2 Rv1873 Rv1874 Rv1875 bfrA Rv1877 glnA3 Rv1879 cyp140 lppE Rv1882c Rv1883c rpfC Rv1885c fbpB Rv1887 Rv1888c Rv1890c Rv1891 Rv1894c Rv1895 dtd lppD lipJ cinA nanT Rv1903 Rv1904 aao Rv1906c Rv1907c katG : catalase-peroxidase KatG monomer furA Rv1910c lppC fadB5 Rv1913 Rv1914c aceAa aceAb PPE34 : PPE family protein PPE34 PPE35 : PPE family protein PPE35 Rv1919c Rv1920 lppF Rv1922 lipD : lipase LipD

2,120,000 2,122,000 2,124,000 2,126,000 2,128,000 2,130,000 2,132,000 2,134,000 2,136,000 2,138,000 2,140,000 2,142,000 2,144,000 2,146,000 2,148,000 2,150,000 2,152,000 2,154,000 2,156,000 2,158,000 2,160,000 2,162,000 2,164,000 2,166,000 2,168,000 2,170,000 2,172,000 2,174,000 2,176,000 Rv1948c Rv1951c vapB14vapC14 Rv1954A secBL parD1 vapB35 vapB36 Rv1990c Rv1990A fadD31 mpt63 Rv1927 Rv1928c Rv1929c Rv1930c Rv1931c tpx fadE18 fadE17 echA13 Rv1936 Rv1937 : possible oxygenase ephB Rv1939 ribA1 Rv1941 mazF5 mazE5 Rv1944c Rv1945 lppG Rv1947 Rv1949c Rv1954c higB higA Rv1958c parE1 Rv1961 vapC35 mce3R yrbE3A yrbE3B mce3A mce3B mce3C mce3D lprM mce3F Rv1972 Rv1973 Rv1974 Rv1975 Rv1976c Rv1977 Rv1978 Rv1979c mpt64 nrdF1 vapC36 PE_PGRS35 cfp21 Rv1985c lysE Rv1987 erm(37) Rv1989c

2,178,000 2,180,000 2,182,000 2,184,000 2,186,000 2,188,000 2,190,000 2,192,000 2,194,000 2,196,000 2,198,000 2,200,000 2,202,000 2,204,000 2,206,000 2,208,000 2,210,000 2,212,000 2,214,000 2,216,000 2,218,000 2,220,000 2,222,000 2,224,000 2,226,000 2,228,000 2,230,000 2,232,000 2,234,000 mazF6mazE6 Rv1993c vapB15 Rv2020c Rv2021c Rv2023c Rv2023A Rv2034 Rv2044c ctpG cmtR Rv1995 Rv1996 ctpF Rv1998c Rv1999c Rv2000 : unknown protein Rv2001 fabG3 Rv2003c Rv2004c Rv2005c otsB1 : trehalose-6-phosphate phosphatase OtsB1 fdxA Rv2008c vapC15 Rv2011c Rv2012 Rv2013 Rv2014 Rv2015c Rv2016 Rv2017 Rv2018 Rv2019 higB2 Rv2024c Rv2025c Rv2026c dosT Rv2028c pfkB Rv2030c : conserved protein hspX acg Rv2033c Rv2035 Rv2036 Rv2037c Rv2038c Rv2039c Rv2040c Rv2041c Rv2042c pncA lipT : carboxylesterase lppI

2,236,000 2,238,000 2,240,000 2,242,000 2,244,000 2,246,000 2,248,000 2,250,000 2,252,000 2,254,000 2,256,000 2,258,000 2,260,000 2,262,000 2,264,000 2,266,000 2,268,000 2,270,000 2,272,000 2,274,000 2,276,000 2,278,000 2,280,000 2,282,000 2,284,000 2,286,000 2,288,000 2,290,000 lppI Rv2049c rpsR2 rpmG1rpmB2 Rv2060 Rv2061c mazE7 Rv2076c Rv2077A Rv2078 Rv2085 Rv2087 Rv2047c : conserved hypothetical protein pks12 : mycoketide-CoA synthase rbpA ppm1 Rv2052c : conserved protein fxsA Rv2054 rpsN2 Rv2059 cobN : cobalamin biosynthesis protein mazF7 cobG cobH cobI Rv2067c blaC sigC cobK cobM cobL Rv2073c Rv2074 Rv2075c Rv2077c Rv2079 lppJ Rv2081c Rv2082 Rv2083 Rv2084 Rv2086 pknJ pepE : dipeptidase Rv2090 Rv2091c

2,292,000 2,294,000 2,296,000 2,298,000 2,300,000 2,302,000 2,304,000 2,306,000 2,308,000 2,310,000 2,312,000 2,314,000 2,316,000 2,318,000 2,320,000 2,322,000 2,324,000 2,326,000 2,328,000 2,330,000 2,332,000 2,334,000 2,336,000 2,338,000 2,340,000 2,342,000 2,344,000 2,346,000 2,348,000 Rv2091c PE_PGRS36 PE21 vapB37 Rv2105 Rv2117 Rv2128 Rv2132 parD2 Rv2144c Rv2146c sepF helY : ATP-dependent DNA helicase tatC tatA pafC pafB pafA Rv2100 helZ : probable helicase Rv2102 vapC37 Rv2106 PE22 PPE36 prcA prcB pup dop Rv2113 Rv2114 mpa lppK Rv2118c Rv2119 Rv2120c hisG hisE PPE37 metH : 5-methyltetrahydrofolate-homocysteine methyltransferase Rv2125 PE_PGRS37 ansP1 Rv2129c mshC cysQ Rv2133c Rv2134c Rv2135c Rv2136c Rv2137c lppL pyrD TB18.6 Rv2141c parE2 Rv2143 wag31

2,350,000 2,352,000 2,354,000 2,356,000 2,358,000 2,360,000 2,362,000 2,364,000 2,366,000 2,368,000 2,370,000 2,372,000 2,374,000 2,376,000 2,378,000 2,380,000 2,382,000 2,384,000 2,386,000 2,388,000 2,390,000 2,392,000 2,394,000 2,396,000 2,398,000 2,400,000 2,402,000 2,404,000 2,406,000 Rv2160c Rv2168c Rv2183c Rv2186c trpD sepF Rv2148c Rv2149c ftsZ ftsQ murC murG ftsW murD murX murF murE Rv2159c Rv2160A Rv2161c PE_PGRS38 pbpB Rv2164c rsmH mraZ Rv2167c Rv2169c Rv2170 lppM Rv2172c idsA2 mptA Rv2175c pknL Rv2177c aroG Rv2179c Rv2180c Rv2181 Rv2182c Rv2184c TB16.3 fadD15 pimB Rv2189c Rv2190c Rv2191 ctaE qcrC qcrA qcrB Rv2197c mmpS3 Rv2199c

2,408,000 2,410,000 2,412,000 2,414,000 2,416,000 2,418,000 2,420,000 2,422,000 2,424,000 2,426,000 2,428,000 2,430,000 2,432,000 2,434,000 2,436,000 2,438,000 2,440,000 2,442,000 2,444,000 2,446,000 2,448,000 2,450,000 2,452,000 2,454,000 2,456,000 2,458,000 2,460,000 2,462,000 Rv2204c Rv2237A accD6 ctaC asnB adoK Rv2203 Rv2205c Rv2206 cobT cobS Rv2209 ilvE gcvT Rv2212 pepB ephD dlaT Rv2216 lipB lipA Rv2219 Rv2219A glnA1 glnE : glutamate-ammonia-ligase adenylyltransferase glnA2 Rv2223c caeA panB Rv2226 : conserved protein rnpB Rv2227 Rv2228c Rv2229c Rv2230c cobC vapC16 ptkA ptpA Rv2235 cobD Rv2237 ahpE Rv2239c Rv2240c aceE Rv2242 fabD acpM kasA kasB

2,464,000 2,466,000 2,468,000 2,470,000 2,472,000 2,474,000 2,476,000 2,478,000 2,480,000 2,482,000 2,484,000 2,486,000 2,488,000 2,490,000 2,492,000 2,494,000 2,496,000 2,498,000 2,500,000 2,502,000 2,504,000 2,506,000 2,508,000 2,510,000 2,512,000 2,514,000 2,516,000 2,518,000 2,520,000 Rv2250A Rv2269c Rv2271 Rv2273 mazE8 Rv2278 Rv2283 Rv2292c Rv2302 Rv2306BRv2307c accD6 Rv2248 glpD1 Rv2250c Rv2251 Rv2252 Rv2253 Rv2254c Rv2256c Rv2257c Rv2258c mscR Rv2260 Rv2261c Rv2262c Rv2263 Rv2264c Rv2265 cyp124 Rv2267c cyp128 lppN Rv2272 mazF8 Rv2275 cyp121 Rv2277c Rv2279 Rv2280 pitB Rv2282c lipM Rv2285 Rv2286c yjcE Rv2288 cdh lppO sseB Rv2293c Rv2294 Rv2295 Rv2296 Rv2297 Rv2298 htpG : probable chaperone protein Rv2300c cut2 Rv2303c Rv2305 Rv2306A

2,522,000 2,524,000 2,526,000 2,528,000 2,530,000 2,532,000 2,534,000 2,536,000 2,538,000 2,540,000 2,542,000 2,544,000 2,546,000 2,548,000 2,550,000 2,552,000 2,554,000 2,556,000 2,558,000 2,560,000 2,562,000 2,564,000 2,566,000 2,568,000 2,570,000 2,572,000 2,574,000 2,576,000 2,578,000 Rv2309A Rv2310 Rv2312 Rv2331A Rv2342 Rv2348c Rv2307c Rv2307B Rv2308 Rv2309c Rv2311 Rv2313c Rv2314c Rv2315c uspA uspB uspC Rv2319c rocE rocD2 rocD1 Rv2323c Rv2324 Rv2325c Rv2326c Rv2327 PE23 narK1 : NarK family protein lppP Rv2331 mez stp cysK1 cysE Rv2336 Rv2337c moeW mmpL9 PE_PGRS39 lppQ dnaG : DNA primase dgt Rv2345 esxO esxP plcC plcB plcA PPE38 PPE39

2,580,000 2,582,000 2,584,000 2,586,000 2,588,000 2,590,000 2,592,000 2,594,000 2,596,000 2,598,000 2,600,000 2,602,000 2,604,000 2,606,000 2,608,000 2,610,000 2,612,000 2,614,000 2,616,000 2,618,000 2,620,000 2,622,000 2,624,000 2,626,000 2,628,000 2,630,000 2,632,000 2,634,000 Rv2354 Rv2365c Rv2369c Rv2375 mbtH aprA aprB Rv2355 PPE40 : PPE family protein PPE40 glyS smtB zur Rv2360c Rv2361c recO amiA2 : probable amidase era Rv2366c ybeY phoH1 Rv2370c rsmE dnaJ2 hrcA cfp2 mbtG mbtF : peptide synthetase mbtE : peptide synthetase mbtD : polyketide synthetase mbtC mbtB : phenyloxazoline synthase mbtA mbtJ mbtI Rv2387 hemN rpfD Rv2390c sirA cysH che1 ggtB Rv2395 mcr7

2,636,000 2,638,000 2,640,000 2,642,000 2,644,000 2,646,000 2,648,000 2,650,000 2,652,000 2,654,000 2,656,000 2,658,000 2,660,000 2,662,000 2,664,000 2,666,000 2,668,000 2,670,000 2,672,000 2,674,000 2,676,000 2,678,000 2,680,000 2,682,000 2,684,000 2,686,000 2,688,000 2,690,000 2,692,000 Rv2401 PE24 Rv2420c Rv2422 oxyR' Rv2433c Rv2438A Rv2446c PE_PGRS41 cysA1 cysW cysT subI Rv2402 : Trehalase lppR lepA Rv2405 Rv2406c rnz Rv2409c Rv2410c Rv2411c rpsT Rv2413c Rv2414c Rv2415c eis Rv2417c octT gpgP nadD Rv2423 Rv2424c Rv2425c Rv2426c proA ahpC ahpD PPE41 PE25 Rv2432c Rv2434c Rv2435c rbsK Rv2437 nadE proB obg rpmA rplU dctA rne : possible ribonuclease E ndkA folC valS : probable valyl-tRNA synthase protein

2,694,000 2,696,000 2,698,000 2,700,000 2,702,000 2,704,000 2,706,000 2,708,000 2,710,000 2,712,000 2,714,000 2,716,000 2,718,000 2,720,000 2,722,000 2,724,000 2,726,000 2,728,000 2,730,000 2,732,000 2,734,000 2,736,000 2,738,000 2,740,000 2,742,000 2,744,000 2,746,000 2,748,000 2,750,000 Rv2468A Rv2472 Rv2480c Rv2481c Rv2489c Rv2449c rpfE Rv2451 mobA Rv2454c Rv2455c Rv2456c clpX mmuM Rv2459 clpP2 clpP1 tig lipP Rv2464c rpiB Rv2466c pepN : probable aminopeptidase N Rv2468c Rv2469c glbO aglA Rv2473 Rv2474c Rv2475c gdh : probable NAD-dependent glutamate dehydrogenase Rv2477c Rv2478c Rv2479c plsB2 plsC Rv2484c lipQ echA14 PE_PGRS42 Rv2488c PE_PGRS43 : PE-PGRS family protein PE_PGRS43 Rv2491

2,752,000 2,754,000 2,756,000 2,758,000 2,760,000 2,762,000 2,764,000 2,766,000 2,768,000 2,770,000 2,772,000 2,774,000 2,776,000 2,778,000 2,780,000 2,782,000 2,784,000 2,786,000 2,788,000 2,790,000 2,792,000 2,794,000 2,796,000 2,798,000 2,800,000 2,802,000 2,804,000 2,806,000 vapB38 Rv2517c Rv2520c vapB17 vapB39 Rv2532c Rv2541 Rv2492 vapC38 bkdC bkdB bkdA citE Rv2499c fadE19 accA1 accD1 scoB scoA fadD35 Rv2506 Rv2507 Rv2508c Rv2509 Rv2510c : conserved protein orn Rv2512c Rv2513 Rv2514c Rv2515c Rv2516c ldtB PE26 bcp Rv2522c acpS fas : type I fatty acid synthase Rv2525c vapC17 mrr Rv2529 vapC39 Rv2531c : probable amino acid decarboxylase nusB efp pepQ Rv2536 aroD aroB aroK aroF

2,808,000 2,810,000 2,812,000 2,814,000 2,816,000 2,818,000 2,820,000 2,822,000 2,824,000 2,826,000 2,828,000 2,830,000 2,832,000 2,834,000 2,836,000 2,838,000 2,840,000 2,842,000 2,844,000 2,846,000 2,848,000 2,850,000 2,852,000 2,854,000 2,856,000 2,858,000 2,860,000 2,862,000 2,864,000 vapB18 vapB19 Rv2548A vapB20 Rv2556c Rv2561 PE_PGRS44 Rv2542 lppA lppB vapC18 vapC19 vapC20 Rv2551c aroE Rv2553c Rv2554c alaS : probable alanyl-tRNA synthetase Rv2557 Rv2558 Rv2559c Rv2560 Rv2562 Rv2563 glnQ Rv2565 Rv2566 : long conserved protein Rv2567 Rv2568c Rv2569c Rv2570 Rv2571c aspS Rv2573 Rv2574 Rv2575 Rv2576c Rv2577 Rv2578c dhaA hisS Rv2581c ppiB relA : probable GTP pyrophosphokinase apt Rv2585c secF secD yajC gabT fadD9 : probable fatty-acid-CoA ligase

2,866,000 2,868,000 2,870,000 2,872,000 2,874,000 2,876,000 2,878,000 2,880,000 2,882,000 2,884,000 2,886,000 2,888,000 2,890,000 2,892,000 2,894,000 2,896,000 2,898,000 2,900,000 2,902,000 2,904,000 2,906,000 2,908,000 2,910,000 2,912,000 2,914,000 2,916,000 2,918,000 2,920,000 vapB40 vapB41 Rv2614A Rv2619c Rv2632c Rv2635 Rv2639c Rv2640c Rv2644c Rv2648 Rv2653c Rv2654c Rv2656cRv2657c PE_PGRS44 ruvB ruvA ruvC vapC40 Rv2597 Rv2598 Rv2599 Rv2600 speE vapC41 Rv2603c snoP tesB2 snzP pdxH PPE42 Rv2609c pimA Rv2611c pgsA1 Rv2613c thrS PE_PGRS45 Rv2616 Rv2617c Rv2618 Rv2620c Rv2621c Rv2622 TB31.7 Rv2624c Rv2625c hrp1 Rv2627c Rv2628 Rv2629 Rv2630 rtcB Rv2633c PE_PGRS46 Rv2636 dedA Rv2638 cadI Rv2642 arsC Rv2645 Rv2646 Rv2647 Rv2649 Rv2650c Rv2651c Rv2652c Rv2655c

2,922,000 2,924,000 2,926,000 2,928,000 2,930,000 2,932,000 2,934,000 2,936,000 2,938,000 2,940,000 2,942,000 2,944,000 2,946,000 2,948,000 2,950,000 2,952,000 2,954,000 2,956,000 2,958,000 2,960,000 2,962,000 2,964,000 2,966,000 2,968,000 2,970,000 2,972,000 2,974,000 2,976,000 2,978,000 Rv2658c Rv2660c Rv2662 Rv2663Rv2664 Rv2665 Rv2694c Rv2699c Rv2705cRv2706c Rv2708c Rv2722

Rv2659c Rv2661c Rv2666 clpC2 Rv2668 Rv2669 Rv2670c ribD Rv2672 aftC msrB Rv2675c Rv2676c hemY hemE echA15 Rv2680 Rv2681 dxs1 Rv2683 arsA arsB1 Rv2686c Rv2687c Rv2688c Rv2689c Rv2690c ceoB ceoC Rv2693c Rv2695 Rv2696c dut Rv2698 Rv2700 suhB ppgK sigA Rv2704 Rv2707 Rv2709 sigB ideR Rv2712c sthA Rv2714 Rv2715 Rv2716 Rv2717c nrdR Rv2719c lexA Rv2721c Rv2723 fadE20

2,980,000 2,982,000 2,984,000 2,986,000 2,988,000 2,990,000 2,992,000 2,994,000 2,996,000 2,998,000 3,000,000 3,002,000 3,004,000 3,006,000 3,008,000 3,010,000 3,012,000 3,014,000 3,016,000 3,018,000 3,020,000 3,022,000 3,024,000 3,026,000 3,028,000 3,030,000 3,032,000 3,034,000 3,036,000 Rv2734 Rv2749 hsdS.1 vapB21 vapB42 Rv2767c Rv2774c fadE20 hflX dapF miaA Rv2728c Rv2729c Rv2730 Rv2731 Rv2732c Rv2733c Rv2735c recX recA Rv2739c ephG PE_PGRS47 Rv2742c Rv2743c 35kd_ag clgR pgsA3 argA ftsK Rv2750 Rv2751 rnj : Ribonuclease J dapA thyX hsdM vapC21 vapC42 hsdS Rv2762c dfrA thyA Rv2765 Rv2766c PPE43 PE27 PPE44 Rv2771c Rv2772c dapB Rv2775 Rv2776c Rv2777c Rv2778c aldR ald Rv2781c pepR gpsI lppU rpsO

3,038,000 3,040,000 3,042,000 3,044,000 3,046,000 3,048,000 3,050,000 3,052,000 3,054,000 3,056,000 3,058,000 3,060,000 3,062,000 3,064,000 3,066,000 3,068,000 3,070,000 3,072,000 3,074,000 3,076,000 3,078,000 3,080,000 3,082,000 3,084,000 3,086,000 3,088,000 3,090,000 3,092,000 Rv2798c mazE9 Rv2805Rv2806 Rv2808 Rv2809 Rv2810c Rv2815c Rv2828A vapB22 Rv2840c ribF Rv2787 mntR fadE21 ltp1 Rv2791c Rv2792c truB pptT Rv2795c lppV Rv2797c Rv2799 Rv2800 : possible hydrolase mazF9 Rv2802c Rv2803 Rv2804c Rv2807 Rv2811 Rv2812 Rv2813 Rv2814c cas2 cas1 csm6 csm5 csm4 csm3 csm2 cas10 cas6 Rv2825c Rv2826c Rv2827c Rv2828c vapC22 echA16 ugpC ugpB ugpE ugpA dinF nrnA rbfA infB nusA rimP Rv2843 Rv2844

3,094,000 3,096,000 3,098,000 3,100,000 3,102,000 3,104,000 3,106,000 3,108,000 3,110,000 3,112,000 3,114,000 3,116,000 3,118,000 3,120,000 3,122,000 3,124,000 3,126,000 3,128,000 3,130,000 3,132,000 3,134,000 3,136,000 3,138,000 3,140,000 3,142,000 3,144,000 3,146,000 3,148,000 3,150,000 vapB23 vapB43 Rv2876 rlmN Rv2891 Rv2898c proS efpA cysG cobB cobO Rv2850c Rv2851c mqo PE_PGRS48 Rv2854 mtr nicT Rv2857c aldC Rv2859c glnA4 mapB Rv2862c vapC23 Rv2864c relF relG Rv2867c gcpE : probable rip dxr vapC43 mpt83 dipZ mpt70 Rv2877c mpt53 rlmN cdsA frr pyrH Rv2884 Rv2885c Rv2886c Rv2887 amiC : probable amidase tsf rpsB PPE45 Rv2893 xerC viuB dprA Rv2897c

3,152,000 3,154,000 3,156,000 3,158,000 3,160,000 3,162,000 3,164,000 3,166,000 3,168,000 3,170,000 3,172,000 3,174,000 3,176,000 3,178,000 3,180,000 3,182,000 3,184,000 3,186,000 3,188,000 3,190,000 3,192,000 3,194,000 3,196,000 3,198,000 3,200,000 3,202,000 3,204,000 3,206,000 3,208,000 Rv2901c Rv2908c Rv2929 fdhD fdhF : possible formate dehydrogenase H rnhB lepB rplS lppW trmD rimM rpsP Rv2910c dacB2 Rv2912c Rv2913c pknI Rv2915c ffh Rv2917 glnD glnB amt ftsY smc : probable chromosome partition protein acyP Rv2923c fpg rnc Rv2926c Rv2927c tesA fadD26 : fatty-acid-AMP ligase ppsA ppsB ppsC ppsD

3,210,000 3,212,000 3,214,000 3,216,000 3,218,000 3,220,000 3,222,000 3,224,000 3,226,000 3,228,000 3,230,000 3,232,000 3,234,000 3,236,000 3,238,000 3,240,000 3,242,000 3,244,000 3,246,000 3,248,000 3,250,000 3,252,000 3,254,000 3,256,000 3,258,000 3,260,000 3,262,000 3,264,000 Rv2943A Rv2960c ppsD ppsE drrA drrB drrC papA5 mas : probable multifunctional mycocerosic acid synthase membrane-associated fadD28 : fatty-acid-AMP ligase mmpL7 Rv2943 Rv2944 lppX pks1 : putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 pks15 fadD22 : P-hydroxybenzoyl-AMP ligase Rv2949c fadD29 : fatty-acid-AMP ligase Rv2951c Rv2952 Rv2953 Rv2954c Rv2955c Rv2956 Rv2957 Rv2958c Rv2959c Rv2961 Rv2962c Rv2963 purU kdtB Rv2966c pca : probable pyruvate carboxylase

3,266,000 3,268,000 3,270,000 3,272,000 3,274,000 3,276,000 3,278,000 3,280,000 3,282,000 3,284,000 3,286,000 3,288,000 3,290,000 3,292,000 3,294,000 3,296,000 3,298,000 3,300,000 3,302,000 3,304,000 3,306,000 3,308,000 3,310,000 3,312,000 3,314,000 3,316,000 3,318,000 3,320,000 3,322,000 Rv2975c leuB PPE47 Rv2968c Rv2969c lipN Rv2971 Rv2972c recG Rv2974c ung thiL Rv2978c Rv2979c Rv2980 ddlA gpdA2 fbiD ppk1 : polyphosphate kinase PPK mutT1 hupB leuD leuC Rv2989 Rv2990c Rv2991 gltS Rv2993c Rv2994 serA1 Rv2997 Rv2998 lppY Rv3000 ilvC ilvN ilvB1 cfp6 Rv3005c lppZ Rv3007c Rv3008 gatB pfkA gatA gatC Rv3013 ligA : DNA ligase [NAD dependent] Rv3015c lpqA esxQ PPE46 esxR esxS

3,324,000 3,326,000 3,328,000 3,330,000 3,332,000 3,334,000 3,336,000 3,338,000 3,340,000 3,342,000 3,344,000 3,346,000 3,348,000 3,350,000 3,352,000 3,354,000 3,356,000 3,358,000 3,360,000 3,362,000 3,364,000 3,366,000 3,368,000 3,370,000 3,372,000 3,374,000 3,376,000 3,378,000 3,380,000 PPE48 Rv3032A Rv3046c Rv3047c Rv3073c PE29 Rv3023c trmU iscS Rv3026c Rv3027c fixB fixA Rv3030 Rv3031 Rv3032 Rv3033 Rv3034c Rv3035 TB22.2 Rv3037c Rv3038c echA17 Rv3040c Rv3041c serB2 ctaD fecB adhC nrdF2 Rv3049c Rv3050c nrdE nrdI nrdH Rv3054c Rv3055 dinP Rv3057c Rv3058c cyp136 Rv3060c fadE22 ligB cstA Rv3064c mmr Rv3066 Rv3067 pgmA : phosphoglucomutase Rv3069 Rv3070 Rv3071 Rv3072c Rv3074

3,382,000 3,384,000 3,386,000 3,388,000 3,390,000 3,392,000 3,394,000 3,396,000 3,398,000 3,400,000 3,402,000 3,404,000 3,406,000 3,408,000 3,410,000 3,412,000 3,414,000 3,416,000 3,418,000 3,420,000 3,422,000 3,424,000 3,426,000 3,428,000 3,430,000 3,432,000 3,434,000 3,436,000 Rv3098A moaD1 Rv3126c Rv3128c Rv3129 Rv3074 Rv3075c Rv3076 Rv3077 : possible hydrolase hab Rv3079c pknK Rv3081 virS mymA lipR Rv3085 adhD Rv3087 tgs4 fadD13 Rv3090 Rv3091 : conserved protein Rv3092c Rv3093c Rv3094c Rv3095 Rv3096 lipY Rv3098c ssr Rv3099c smpB ftsX ftsE Rv3103c Rv3104c prfB fprA agpS Rv3108 moaA1 moaB1 moaC1 Rv3113 Rv3114 Rv3115 moeB2 cysA3 sseC1 moaE1 Rv3120 cyp141 Rv3122 Rv3123 moaR1 PPE49 Rv3127

3,438,000 3,440,000 3,442,000 3,444,000 3,446,000 3,448,000 3,450,000 3,452,000 3,454,000 3,456,000 3,458,000 3,460,000 3,462,000 3,464,000 3,466,000 3,468,000 3,470,000 3,472,000 3,474,000 3,476,000 3,478,000 3,480,000 3,482,000 3,484,000 3,486,000 3,488,000 3,490,000 3,492,000 3,494,000 Rv3136A Rv3183 Rv3184 tgs1 Rv3131 devS devR Rv3134c PPE50 PPE51 hisN pflA fadE24 fadE23 fadB4 Rv3142c Rv3143 PPE52 nuoA nuoB nuoC nuoD nuoE nuoF nuoG nuoH nuoI nuoJ nuoK nuoL nuoM nuoN PPE53 Rv3160c Rv3161c Rv3162c Rv3163c moxR3 Rv3165c Rv3166c Rv3167c Rv3168 Rv3169 aofH hpx Rv3172c Rv3173c Rv3174 Rv3175 mesT Rv3177 Rv3178 Rv3179 Rv3180c vapB49 higB3 Rv3185

3,496,000 3,498,000 3,500,000 3,502,000 3,504,000 3,506,000 3,508,000 3,510,000 3,512,000 3,514,000 3,516,000 3,518,000 3,520,000 3,522,000 3,524,000 3,526,000 3,528,000 3,530,000 3,532,000 3,534,000 3,536,000 3,538,000 3,540,000 3,542,000 3,544,000 3,546,000 3,548,000 3,550,000 3,552,000 Rv3185 Rv3186 Rv3188 whiB7 Rv3198A Rv3204 TB9.4 Rv3216 whiB1 TB7.3 Rv3224B Rv3187 Rv3189 Rv3190c Rv3191c Rv3192 Rv3193c : probable conserved transmembrane protein Rv3194c Rv3195 Rv3196 Rv3197 uvrD2 nudC Rv3200c Rv3201c : probable ATP-dependent DNA helicase Rv3202c : possible ATP-dependent DNA helicase lipV Rv3205c moeB1 Rv3207c Rv3208 Rv3209 Rv3210c rhlE Rv3212 Rv3213c gpm2 entC Rv3217c Rv3218 Rv3220c rshA Rv3222c sigH Rv3224 Rv3225c Rv3226c aroA Rv3228 desA3 Rv3230c Rv3231c ppk2

3,554,000 3,556,000 3,558,000 3,560,000 3,562,000 3,564,000 3,566,000 3,568,000 3,570,000 3,572,000 3,574,000 3,576,000 3,578,000 3,580,000 3,582,000 3,584,000 3,586,000 3,588,000 3,590,000 3,592,000 3,594,000 3,596,000 3,598,000 3,600,000 3,602,000 3,604,000 3,606,000 3,608,000 rubB rubA whiB2 Rv3269 ppk2 Rv3233c tgs3 Rv3235 Rv3236c Rv3237c Rv3238c Rv3239c secA1 : probable preprotein translocase hpf Rv3242c Rv3243c lpqB mtrB mtrA tmk sahH Rv3249c alkB Rv3253c Rv3254 manA Rv3256c pmmA Rv3258c Rv3259 fbiA fbiB Rv3263 manB wbbL1 rmlD Rv3267 Rv3268 ctpC Rv3271c Rv3272 Rv3273 fadE25 purE purK Rv3277 Rv3278c birA accD5 accE5 Rv3282 sseA Rv3284 accA3

3,610,000 3,612,000 3,614,000 3,616,000 3,618,000 3,620,000 3,622,000 3,624,000 3,626,000 3,628,000 3,630,000 3,632,000 3,634,000 3,636,000 3,638,000 3,640,000 3,642,000 3,644,000 3,646,000 3,648,000 3,650,000 3,652,000 3,654,000 3,656,000 3,658,000 3,660,000 3,662,000 3,664,000 3,666,000 Rv3289c Rv3312A vapB44 Rv3325 Rv3337 accA3 sigF rsbW usfY lat lrpA Rv3292 pcd Rv3294c Rv3295 lhr : probable ATP-dependent helicase nei lpqC atsB : probable arylsulfatase Rv3300c phoY1 glpD2 lpdA Rv3304 amiA1 amiB1 deoD pmmB upp sapM Rv3311 Rv3312c add deoA cdd sdhC sdhD sdhA sdhB vapC44 Rv3322c moaX moaC3 Rv3326 Rv3327 sigJ Rv3329 dacB1 sugI nagA Rv3333c Rv3334 Rv3335c trpS Rv3338

3,668,000 3,670,000 3,672,000 3,674,000 3,676,000 3,678,000 3,680,000 3,682,000 3,684,000 3,686,000 3,688,000 3,690,000 3,692,000 3,694,000 3,696,000 3,698,000 3,700,000 3,702,000 3,704,000 3,706,000 3,708,000 3,710,000 3,712,000 3,714,000 3,716,000 3,718,000 3,720,000 3,722,000 3,724,000 PE_PGRS49 Rv3346c Rv3352c Rv3353c Rv3355c Rv3363c Rv3364c Rv3338 icd1 metC metX Rv3342 PPE54 : PPE family protein PPE54 PE_PGRS50 : PE-PGRS family protein PE_PGRS50 PPE55 : PPE family protein PPE55 Rv3348 Rv3349c PPE56 : PPE family protein PPE56 Rv3351c Rv3354 folD relJ relK Rv3359 Rv3360 mfpA Rv3362c Rv3365c : conserved protein spoU PE_PGRS51 Rv3368c Rv3369

3,726,000 3,728,000 3,730,000 3,732,000 3,734,000 3,736,000 3,738,000 3,740,000 3,742,000 3,744,000 3,746,000 3,748,000 3,750,000 3,752,000 3,754,000 3,756,000 3,758,000 3,760,000 3,762,000 3,764,000 3,766,000 3,768,000 3,770,000 3,772,000 3,774,000 3,776,000 3,778,000 3,780,000 echA18.1 Rv3381c vapB46 vapB47 dnaE2 : probable DNA polymerase III (alpha chain) Rv3371 otsB2 echA18 amiD : probable amidase Rv3376 Rv3377c Rv3378c dxs2 Rv3380c lytB1 idsB vapC46 Rv3386 Rv3387 PE_PGRS52 htdY lpqD acrA1 cmaA1 iunH Rv3394c Rv3395c Rv3395A guaA phyA idsA1 Rv3399 Rv3400 Rv3401 Rv3402c Rv3403c Rv3404c Rv3405c Rv3406 vapC47 choD : cholesterol oxidase guaB3 guaB2 Rv3412 Rv3413c sigD Rv3415c whiB3 groEL1 : 60 kDa chaperonin 1 groES gcp

3,782,000 3,784,000 3,786,000 3,788,000 3,790,000 3,792,000 3,794,000 3,796,000 3,798,000 3,800,000 3,802,000 3,804,000 3,806,000 3,808,000 3,810,000 3,812,000 3,814,000 3,816,000 3,818,000 3,820,000 3,822,000 3,824,000 3,826,000 3,828,000 3,830,000 3,832,000 3,834,000 3,836,000 3,838,000 Rv3424c Rv3440c Rv3453 infA Rv3466 Rv3474 rimI Rv3421c tsaE alr PPE57 PPE58 Rv3427c Rv3428c PPE59 Rv3430c Rv3431c gadB nnr Rv3434c Rv3435c glmS Rv3437 Rv3438 Rv3439c mrsA rpsI rplM esxT esxU Rv3446c eccC4 eccD4 mycP4 eccB4 cut3 cut4 Rv3454 truA rplQ rpoA rpsD rpsK rpsM Rv3463 rmlB rmlC Rv3467 Rv3468c mhpE ilvB2 Rv3471c Rv3472 bpoA Rv3475 kgtP PE31 PPE60

3,840,000 3,842,000 3,844,000 3,846,000 3,848,000 3,850,000 3,852,000 3,854,000 3,856,000 3,858,000 3,860,000 3,862,000 3,864,000 3,866,000 3,868,000 3,870,000 3,872,000 3,874,000 3,876,000 3,878,000 3,880,000 3,882,000 3,884,000 3,886,000 3,888,000 3,890,000 3,892,000 3,894,000 Rv3488 fdxD Rv3479 : possible transmembrane protein Rv3480c Rv3481c Rv3482c Rv3483c cpsA Rv3485c Rv3486 lipF otsA Rv3491 Rv3492c Rv3493c mce4F lprN mce4D mce4C mce4B mce4A yrbE4B yrbE4A Rv3502c fadE26 fadE27 fadD17 PE_PGRS53 : PE-PGRS family protein PE_PGRS53 PE_PGRS54 : PE-PGRS family protein PE_PGRS54 ilvX Rv3510c PE_PGRS55 PE_PGRS56 : PE-PGRS family protein PE_PGRS56 fadD18 PE_PGRS57 : PE-PGRS family protein PE_PGRS57 fadD19 echA19

3,896,000 3,898,000 3,900,000 3,902,000 3,904,000 3,906,000 3,908,000 3,910,000 3,912,000 3,914,000 3,916,000 3,918,000 3,920,000 3,922,000 3,924,000 3,926,000 3,928,000 3,930,000 3,932,000 3,934,000 3,936,000 3,938,000 3,940,000 3,942,000 3,944,000 3,946,000 3,948,000 3,950,000 3,952,000 Rv3541c Rv3566A Rv3517 cyp142 Rv3519 Rv3520c Rv3521 ltp4 ltp3 Rv3524 Rv3525c kshA Rv3527 Rv3528c Rv3529c Rv3530c Rv3531c PPE61 PPE62 hsaF hsaG hsaE kstD Rv3538 PPE63 ltp2 Rv3542c fadE29 fadE28 cyp125 fadA5 ddn Rv3548c Rv3549c echA20 ipdA ipdB ipdC fdxB Rv3555c fadA6 Rv3557c PPE64 ipdF fadE30 fadD3 fadE31 fadE32 fadE33 aspB nat hsaB hsaC hsaD

3,954,000 3,956,000 3,958,000 3,960,000 3,962,000 3,964,000 3,966,000 3,968,000 3,970,000 3,972,000 3,974,000 3,976,000 3,978,000 3,980,000 3,982,000 3,984,000 3,986,000 3,988,000 3,990,000 3,992,000 3,994,000 3,996,000 3,998,000 4,000,000 4,002,000 4,004,000 4,006,000 4,008,000 4,010,000 Rv3612c hsaD hsaA kshB Rv3572 fadE34 kstR Rv3575c lppH Rv3577 arsB2 Rv3579c cysS1 ispF ispD Rv3583c lpqE radA : DNA repair protein disA Rv3587c canB mutY PE_PGRS58 Rv3591c mhuD lpqF Rv3594 PE_PGRS59 clpC1 lsr2 lysS coaX panD panC Rv3603c Rv3604c Rv3605c folK folB folP1 folE ftsH : membrane-bound protease Rv3611 espD espC espA ephA Rv3618 esxV esxW PPE65 PE32 lpqG hpt mesJ Rv3626c Rv3627c ppa

4,012,000 4,014,000 4,016,000 4,018,000 4,020,000 4,022,000 4,024,000 4,026,000 4,028,000 4,030,000 4,032,000 4,034,000 4,036,000 4,038,000 4,040,000 4,042,000 4,044,000 4,046,000 4,048,000 4,050,000 4,052,000 4,054,000 4,056,000 4,058,000 4,060,000 4,062,000 4,064,000 4,066,000 Rv3632 Rv3643 cspA PE_PGRS60 Rv3654c Rv3655c MTS2823 Rv3629c Rv3630 Rv3631 Rv3633 galE1 Rv3635 Rv3636 Rv3637 Rv3638 Rv3639c Rv3640c fic Rv3644c Rv3645 topA : DNA topoisomerase I Rv3647c Rv3649 : probable helicase PE33 Rv3651 PE_PGRS61 Rv3657c Rv3658c Rv3659c Rv3660c Rv3661 Rv3662c dppD dppC dppB dppA acs : acetyl-coenzyme A synthetase Rv3668c Rv3669 ephE Rv3671c Rv3672c Rv3673c nth Rv3675 crp Rv3677c Rv3678c Rv3679 Rv3680 whiB4 ponA2 Rv3683

4,068,000 4,070,000 4,072,000 4,074,000 4,076,000 4,078,000 4,080,000 4,082,000 4,084,000 4,086,000 4,088,000 4,090,000 4,092,000 4,094,000 4,096,000 4,098,000 4,100,000 4,102,000 4,104,000 4,106,000 4,108,000 4,110,000 4,112,000 4,114,000 4,116,000 4,118,000 4,120,000 4,122,000 4,124,000 Rv3683 Rv3686c vapB48 Rv3705A Rv3706c Rv3716c cut5a Rv3684 cyp137 rsfB Rv3688c Rv3689 Rv3690 Rv3691 moxR2 Rv3693 Rv3694c Rv3695 glpK vapC48 Rv3698 : conserved protein Rv3699 egtE egtD egtC egtB gshA Rv3705c Rv3707c asd ask : aspartokinase leuA : 2-isopropylmalate synthase dnaQ Rv3712 cobQ2 Rv3714c recR Rv3717 Rv3718c Rv3719 Rv3720 dnaZX Rv3722c C8 Rv3723 cut5b Rv3725 Rv3726 Rv3727 Rv3728 : probable conserved two-domain membrane protein Rv3729 : possible transferase Rv3730c ligC

4,126,000 4,128,000 4,130,000 4,132,000 4,134,000 4,136,000 4,138,000 4,140,000 4,142,000 4,144,000 4,146,000 4,148,000 4,150,000 4,152,000 4,154,000 4,156,000 4,158,000 4,160,000 4,162,000 4,164,000 4,166,000 4,168,000 4,170,000 4,172,000 4,174,000 4,176,000 4,178,000 4,180,000 4,182,000 PPE67 Rv3742c Rv3745c Rv3750c Rv3751 Rv3760 Rv3769 Rv3771c ligC Rv3732 Rv3733c tgs2 Rv3735 Rv3736 Rv3737 PPE66 Rv3740c Rv3741c ctpJ nmtR PE34 Rv3747 Rv3748 vapC50 Rv3752c Rv3753c tyrA Rv3755c proZ proW proV proX fadE36 Rv3762c : possible hydrolase lpqH tcrY tcrX Rv3766 Rv3767c Rv3768 Rv3770c hisC2 Rv3773c echA21 lipE Rv3776 Rv3777 Rv3778c Rv3779 bpa rfbE glfT1 rfbD Rv3784 Rv3785 Rv3786c Rv3787c Rv3788 Rv3789 dprE1 dprE2 aftA

4,184,000 4,186,000 4,188,000 4,190,000 4,192,000 4,194,000 4,196,000 4,198,000 4,200,000 4,202,000 4,204,000 4,206,000 4,208,000 4,210,000 4,212,000 4,214,000 4,216,000 4,218,000 4,220,000 4,222,000 4,224,000 4,226,000 4,228,000 4,230,000 4,232,000 4,234,000 4,236,000 4,238,000 Rv3819 embC : arabinogalactan arabinosyl transferase embA : arabinogalactan arabinosyl transferase embA embB : arabinogalactan arabinosyl transferase embB Rv3796 fadE35 Rv3798 accD4 pks13 : Pks13 fadD32 : acyl-CoA synthetase Rv3802c fbpD fbpA aftB ubiA Rv3807c glfT2 glf pirG Rv3811 PE_PGRS62 Rv3813c Rv3814c Rv3815c Rv3816c Rv3817 Rv3818 papA2 Rv3821 Rv3822 mmpL8 : conserved integral membrane transport protein papA1 pks2 : phthioceranic/hydroxyphthioceranic acid synthase

4,240,000 4,242,000 4,244,000 4,246,000 4,248,000 4,250,000 4,252,000 4,254,000 4,256,000 4,258,000 4,260,000 4,262,000 4,264,000 4,266,000 4,268,000 4,270,000 4,272,000 4,274,000 4,276,000 4,278,000 4,280,000 4,282,000 4,284,000 4,286,000 4,288,000 4,290,000 4,292,000 4,294,000 4,296,000 Rv3851 Rv3861 pks2 fadD23 Rv3827c Rv3828c Rv3829c Rv3830c Rv3831 Rv3832c Rv3833 serS Rv3835 Rv3836 Rv3837c pheA Rv3839 Rv3840 bfrB glpQ1 Rv3843c Rv3844 Rv3845 sodA Rv3847 Rv3848 espR Rv3850 Rv3852 rraA ethA ethR Rv3856c gltD gltB : probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) Rv3860 whiB6 Rv3863 espE espF espG1 espH eccA1 eccB1 eccCa1 eccCb1 PE35 PPE68 esxB esxA espI

4,298,000 4,300,000 4,302,000 4,304,000 4,306,000 4,308,000 4,310,000 4,312,000 4,314,000 4,316,000 4,318,000 4,320,000 4,322,000 4,324,000 4,326,000 4,328,000 4,330,000 4,332,000 4,334,000 4,336,000 4,338,000 4,340,000 4,342,000 4,344,000 4,346,000 4,348,000 4,350,000 4,352,000 4,354,000 PE36 Rv3898c LH57_21250 Rv3922c rpmH espI eccD1 espJ espK espL espB eccE1 mycP1 eccA2 eccE2 mycP2 eccD2 Rv3888c espG2 esxC esxD PPE69 eccC2 eccB2 Rv3896c Rv3897c Rv3899c Rv3900c Rv3901c Rv3903c esxE esxF Rv3906c pcnA mutT4 Rv3909 : conserved protein Rv3910 : probable conserved transmembrane protein sigM Rv3912 trxB2 trxC Rv3915 Rv3916c parB parA gid Rv3920c Rv3921c rnpA

4,356,000 4,358,000 4,360,000 4,362,000 4,364,000 4,366,000 4,368,000 4,370,000 4,372,000 4,374,000 4,376,000 4,378,000 4,380,000 4,382,000 4,384,000 4,386,000 4,388,000 4,390,000 4,392,000 4,394,000 4,396,000 4,398,000 4,400,000 4,402,000 4,404,000 4,406,000 4,408,000 4,410,000