DEPARTMENT OF MEDICINE 2014 Annual Report

DIVISIONS AND INSTITUTES

The Divisions The Institutes »» Allergy »» Institute for Clinical Research and John Ohman, MD Health Policy Studies »» Cardiology Harry Selker, MD James Udelson, MD »» Molecular Cardiology Research Institute* »» Clinical Decision Making, Informatics Richard Karas, MD, PhD Telemedicine» »» Molecular Oncology Research Institute* John Wong, MD Philip Tsichlis, MD »» Clinical Nutrition Edward Saltzman, MD »» Endocrinology Ron Lechan, MD »» Gastroenterology Joel Weinstock, MD »» Geographic Medicine and Infectious Disease David Snydman, MD »» Hematology/Oncology Andrew Evens, DO, MSc »» Internal Medicine and Adult Primary Care Deborah Blazey-Martin, MD, MPH »» Nephrology Andrew Levey, MD »» Pulmonary, Critical Care and Sleep Medicine Nicholas Hill, MD »» Rheumatology Timothy McAlindon, MD

Photography by Martha Stewart Photography.

TUFTS MEDICALDesign and CENTER production DEPARTMENT by Mark VincentOF MEDICINE Communications, — ANNUAL REPORTInc. — www.markvincent.net. 2014 TABLE OF CONTENTS

The Department of Medicine Chairman’s Message 4 Departmental Organization Chart 6 Departmental Leadership 6 Clinical Activity 10 Research Activity 11 Internal Medicine Training Program 13

The Divisions 14 Allergy 16 Cardiology 18 Clinical Care Research 33 Clinical Decision Making, Informatics and Telemedicine 34 Clinical Nutrition 38 Endocrinology, Diabetes and Metabolism 41 Gastroenterology 49 Geographic Medicine and Infectious Diseases 54 Hematology/Oncology 63 Internal Medicine and Adult Primary Care 80 Geriatrics 90 William B. Schwartz Division of Nephrology 91 Pulmonary, Critical Care and Sleep Medicine 100 Rheumatology 108

The Institutes 116 Institute for Clinical Research and Health Policy Studies 118 Molecular Cardiology Research Institute (MCRI) 132 Molecular Oncology Research Institute (MORI) 140

Publications 145 CHAIRMAN’S MESSAGE

2014 saw a change in the administrative leadership of the Department of Medicine. Matthew Larkin, Administrative Director, was promoted to Vice President of Operations for the Tufts Medical Center Physicians Organization. He was replaced by Allison Ankeny, JD, MPH, whose administrative experience in both clinical and research endeavors at prestigious medical institutions will be of great value to the department.

Clinical activity for the Department of Medicine showed a decrease in inpatient activity and an increase in outpatient activity for virtually all divisions, in keeping with trends throughout the country. There was gratifying growth in our two new community-based practices, i.e. in Quincy and Framingham. Deeb N. Salem, MD, FACP, FACC, FACCP— The Sheldon M. Wolff Professor and Research activity grants and contracts grew from a total of $34 million in FY 2013 to Chairman, Department of Medicine $36 million in 2014, a significant accomplishment in light of the expiration of many grants that were part of the fiscal stimulus and the generally harsher climate for government-funded research. The Institutes and Divisions have responded to the decrease in NIH-funded research by actively pursuing diversification of funding sources, which has resulted in significant growth in industry-funded projects and clinical trials, and awards from private foundation.

The Division of Cardiology stood out for its cardiac transplantation, ventricular assist and hypertrophic cardiomyopathy programs, the largest such programs in New England. Its referral network for complex catheter-based coronary structural heart failure and electrophysiology procedures grew as did its trans-aortic valve program. Many members of the Division were named among Boston Magazine’s Top Doctors.

John Wong, chief of the Division of Clinical Decision-Making, was named to the Institute of Medicine committee on Diagnostic Error in Health Care and served as a member of the AASLD committee on guidelines for the management of Hepatitis B. Jerome Kassirer was keynote lecturer at the European meeting of the Society for Medical Decision Making. Stephen Pauker served as a member of the End-of-Life committee of the Institute of Medicine.

Edward Saltzman, chief of the Division of Nutrition, was named Academic Dean for Education at the Friedman School of Nutrition Science and Policy. The Division of Endocrinology received a grant renewal from the Friedman Foundation for Medical Research to support research and fellowship training.

The Division of Gastroenterology substantially expanded its food hypersensitivity consultation center, under the directorship of John Leung. A new gastrointestinal motility service was established under the supervision of Harmony Allison.

The Division of Geographic Medicine and Infectious Diseases received renewed funding of a 5 year training grant for the study of Microbial Pathogenesis. New faculty members were recruited to bring additional expertise to the study of hepatitis C and Lyme disease. Sherwood Gorbach was named Emeritus Professor of Medicine and Susan Hadley was awarded the Zucker Prize for outstanding accomplishment in teaching. Helen Boucher was named to the Infectious Disease subspecialty board of the ABIM.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 The Division of Hematology/Oncology recruited two faculty members with expertise in neuro-oncology and thoracic cancers and melanoma. A new electronic medical record was launched to integrate adult and pediatric hematology/ oncology, radiation oncology and gynecological oncology. An initiative was developed to facilitate navigation by the center’s Asian population. Other programs with philanthropic support will address cancer fatigue, holistic cancer care and sickle cell disease. Additional gifts include a sophisticated fluorescence resonance microscopy unit, a seed pledge for a multiple myeloma program, prostate research, and a survivorship program for adolescents and young adults.

The Division of Internal Medicine and Adult Primary Care added 3 new primary care physicians and entered into the New England Quality Care Alliance ACO. The Division received an award from Blue Cross/Blue Shield for the detection of depression and a grant to initiate point-of-care testing for HbA1c in diabetic patients. Its new outpatient offices in Quincy and Framingham showed promising growth.

The William B. Schwartz Division of Nephrology received a number of significant honors. Dr. Levey was recognized by Thomson Reuters as a highly influential researcher, Dr. Meyer received a Distinguished Faculty Award from the medical school and Dr. Perrone was the recipient of the Physician of the Year Award from the Polycystic Kidney Foundation and of the Seldin Award for clinical excellence from the National Kidney Foundation.

Members of the Division of Pulmonary, Critical Care and Sleep Medicine also received notable honors. Nicholas Hill was appointed Chair of the steering committee of the NIH-sponsored Pulmonary Vascular Diseasomics project and Ioana Preston was appointed Chair of the Educational Committee of the Pulmonary Hypertension Association.

In the Division of Rheumatology, Dr. Arabelovic received a medical student preceptorship grant. Other members were honored by academic promotions and appointments.

Among the three Institutes, The Institute for Clinical Research and Health Policy Studies (ICRHPS) received over $6 million in new funding for 25 new research projects. Several faculty members were appointed to major national panels. Investigators in The Molecular Cardiology Research Institute (MCRI) identified a critical predictor of risk for heart disease and sudden death in diabetics. Gordon Huggins was named Principal Investigator of the Tufts Medical Center Regional Heart Failure Network and Iris Jaffee received a prestigious Established Investigator Award from the American Heart Association. Members of the Molecular Oncology Research Institute received 7 new research awards for a total of $1.23 million, delivered numerous invited lectures and were authors of 55 publications.

For details of these and many other achievements, please read the full report and the list of publications.

Sincerely, Deeb Salem

5 DEPARTMENTAL LEADERSHIP

Deeb N. Salem, MD, FACP, FACC, FACCP Dr. Deeb Salem has had a distinguished career as an academic cardiologist. In 1987, he was appointed Professor of Medicine at Tufts University School of Medicine. He served as Chief of Cardiology at the Tufts New England Medical Center from 1987 to 1995 and was appointed the Sheldon M Wolff Professor and Chairman of the Department of Medicine at Tufts University School of Medicine and Physician-in- Chief of Tufts Medical Center in 1999. He is a Fellow of the American College of Cardiology, the American College of Physicians, and the American College of Chest Physicians.

Dr. Salem was the founding President of the New England Affiliate of the American Heart Association. His academic accomplishments include over one hundred and seventy scientific publications. He is recognized as a national expert in coronary artery disease, valvular heart disease and congestive heart failure. Dr. Salem received the Distinguished Alumni Award from Boston University School of Medicine in 1998, the Distinguished Faculty Award from Tufts University School of Medicine in 1998, an American Heart Association Great Communicator Award in 1999 and an American Heart Association Distinguished Leadership Award in 2000. He received the Massachusetts Physician Health Service Distinguished Service Award in 2003. In 2007, Dr. Salem was the recipient of the American Heart Association’s Paul Dudley White Lifetime Achievement award. In August of 2007, Dr. Salem received the Champions in Healthcare, Lifetime Achievement Award from the Boston Business Journal. He has repeatedly been listed in Boston Magazine as one of “Boston’s Best” physicians. In 2010 Dr Salem was awarded the Working Wonders Lifetime Achievement Award by Tufts Medical Center.

He is on the Executive Board of the Board of Trustees of Tufts Medical Center and is an emeritus member of the Board of Directors of the Northeast Affiliate of the American Heart Association. Dr Salem is also on the Board of Director of the Wang Chinatown YMCA, the Asian American Civic Association, the New England Quality Care Alliance (NEQCA), the Tufts Medical Center Physicians Organization, the Tufts Health Care Institute. He was elected to the Publications Committee of the New England Journal of Medicine in 2003 and became Vice Chair of that Committee in the spring of 2009. In 2010, Dr. Salem was elected Chairman of the Mass Medical Society’s Committee on Sponsored Programs and Chairman of the Tufts University School of Medicine's Graduate Medical Education Committee. He currently is on the Executive Advisory Board of the New England Journal of Medicine, Chairman of the NEQCA Finance Committee and a member of the Tufts Medical Center's Quality of Care Committee, Finance Committee and Strategic Planning Committee. In 2014, Dr. Salem was elected to the Board of Trustees of the Massachusetts Hospital Association and in 2015 became a member of the Wellforce Finance Committee.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Michael Barza, MD, FACP Dr. Michael Barza is Vice Chair for Clinical Affairs at Tufts Medical Center and Professor of Medicine at Tufts University School of Medicine. In 2012, he was named the Sara Murray Jordan Professor of Medicine at Tufts University School of Medicine.

Dr. Barza joined the faculty of Tufts-New England Medical Center in 1972. He served as Associate Chief of the Division of Geographic Medicine and Infectious Disease as well as hospital epidemiologist. He is a Fellow of the American College of Physicians and of the Infectious Diseases Society of America.

Dr. Barza has been an author or coauthor of over 200 peer-reviewed papers in infectious diseases. Supported by NIH grants, he undertook a number of fundamental studies of the pharmacology of antibiotics in the eye. He also became known as a superior clinician and teacher with a special interest in complex infections. He is named in all recent editions of the national compendium of “Best Doctors”. In 1998, Dr. Barza left T-NEMC to go to the Carney Hospital where he served as Chief of Medicine through 2014. In 2008, while retaining his positions at Carney Hospital, he returned to Tufts Medical Center to assume his current positions.

Having a longstanding interest in the publication of scientific information, Dr. Barza has served as Editor of Antimicrobial Agents and Chemotherapy, Associate Editor for the Yearbook of Infectious Diseases and Senior Editor of Infectious Diseases in Clinical Practice, and was a member of the Institute of Medicine scientific panel on Human Health Risks with Penicillin or Tetracyclines in Animal Feed. He is currently Deputy Editor of Clinical Infectious Diseases, a premier infectious disease journal.

Dr. Barza has made major teaching contributions to the School of Medicine. He has taught for over 25 years in the Infectious Disease Pathophysiology course and has consistently received outstanding evaluations by students. He is the recipient of the Distinguished Faculty Award for 2007, the Zucker Clinical Teaching Prize for Outstanding Accomplishment in 2008 and Outstanding Tufts University School of Medicine Lecturer for 2009-2010.

Linden Hu, MD Linden T. Hu, MD, was appointed Vice-Chairman for Faculty Development for the Department of Medicine in 2008. He is also Associate Chief for Research in the Division of Geographic Medicine and Infectious Diseases at Tufts Medical Center. He is a Professor of Medicine at Tufts University School of Medicine.

After receiving his MD from Brown University, Dr. Hu did an internship and residency in internal medicine at St. Elizabeth’s Medical Center in Boston. He completed a fellowship in Infectious Diseases at Tufts Medical Center.

Dr. Hu is involved in both clinical and laboratory based research into Lyme disease. His focus is on the mechanisms by which the spirochete adapts to its various natural hosts and evades the host immune responses. His laboratory is also developing reservoir-targeted vaccines to reduce transmission of tick borne diseases in the wild. Recently, his laboratory has begun to investigate interactions in bacterial communities using a dental model of periodontitis. He is an author or co-author of over 40 peer-reviewed publications and his laboratory is supported by 7 grants from the NIH.

Dr. Hu has been a member or Chairman of numerous peer review committees for the NIH and the National Research Fund for Tick-borne Diseases. He has received a Daland Fellowship from the American Philosophical Society and the Maxwell Finland Award from the Massachusetts Infectious Disease Society and is a Fellow of the Infectious Disease Society of America. In 2010, he was elected to the American Society for Clinical Investigation. Dr. Hu teaches at Tufts Medical School and at the Sackler School of Graduate Biomedical Studies where he is training faculty in the Programs in Microbiology and in Immunology.

Richard Karas, MD, PhD Richard H. Karas, MD, PhD, has served as Vice-Chairman for Research for the Department of Medicine since 2008. He is also the Chief Scientific Officer at Tufts Medical Center, where he also serves as the Executive Director of the Molecular Cardiology Research Institute, and Co-director of the Women’s Heart Center. He is the Elisa Kent Mendelsohn Professor of Medicine at Tufts University School of Medicine.

7 Before earning his medical degree from the Tufts University School of Medicine, Dr Karas received a PhD in comparative physiology of exercise from Harvard University. After internship and residency in internal medicine at the Brigham and Women’s Hospital, Boston, he completed a clinical fellowship in cardiology at Duke University Medical Center and a research fellowship in cardiology at the University of Texas Southwestern Medical Center, Dallas.

Dr Karas’ main areas of research, supported by grants from the NIH and American Heart Assocation, are the effects of steroid sex hormones on vascular cell biology, mouse models of cardiovascular disease, and the effects of lipid-lowering and hormone therapies on vasomotor function. He has been an author or co-author of over 180 scientific articles, reviews, and book chapters.

Dr Karas serves on the National American Heart Association Research Committee and he currently Chairs the Policy and Evaluation Sub-committee. He was most recently the Chairman of the National American Heart Association committee on Cardiovascular Diseases in Women and Special Populations. At the Howard Hughes Medical Institute, he was a member of the Review Committee for Research Training Fellowships for Medical Students. He also has been an ad hoc member of peer review committees for the NIH and the Swiss National Science Foundation. He has been an editorial board member for Endocrinology and Atherosclerosis. He was awarded the Pfizer Postdoctoral Fellowship in Cardiology, the Young Investigators Award from the American College of Cardiology, and the Established Investigator Award from the American Heart Association. Dr. Karas is also the recipient of the Kynett Foundation Award and he received the Distinguished Faculty Award from Tufts University School of Medicine in 2012.

Dr Karas is a fellow of the American Heart Association and of the American College of Cardiology. He is a member of the Endocrine Society, the North American Menopause Society, and the American Heart Association’s Basic Science Council, Council on Epidemiology and Prevention, and the Clinical Cardiology Council.

Jerome P. Kassirer, MD Dr. Kassirer has been a member of the faculty of Tufts University School of Medicine for more than five decades, and served as Vice Chairman of the Department of Medicine for 20 years. His research has encompassed diverse fields including acid-base balance, medical decision-making, and cognitive science. Dr. Kassirer has served as a governor and regent of the American College of Physicians, chair of the American Board of Internal Medicine, and from 1991 to 1999, as Editor-in-Chief of the New England Journal of Medicine. He currently serves on the Journal Oversight Committee of the Canadian Medical Association Journal and on the Human Factors Subcommittee of the National Commission on Forensic Science.

He is the recipient of numerous awards, several honorary degrees, and a Mastership in the American College of Physicians. He is a member of the Institute of Medicine of the National Academy of Sciences, the Association of American Physicians, and the American Academy of Arts and Sciences. He is currently a Distinguished Professor at Tufts University School of Medicine and Consultant, Department of Medicine at Stanford University and the Center for Outcomes Research and Evaluation at Yale University. Dr. Kassirer has written extensively about health care, for-profit medicine, and financial conflict of interest. He is the author of the current Oxford University Press book, “On the Take: How Medicine’s Complicity with Big Business Can Endanger Your Health.” and a co-author of the book “Learning Clinical Reasoning.”

Richard Kopelman, MD, FACP Richard Kopelman, MD, is the Vice-Chairman for Education in the Department of Medicine and the Louisa C. Endicott Professor of Medicine at Tufts University School of Medicine. He began his academic career at Tufts as one of the first faculty members in the newly created Division of General Medicine in the early 1980s. He has been acting chief of that division on several occasions. He has been Director of the Medical House Staff Training Program since 1981, overseeing the growth of the house staff from 30 members to its current total of 72 interns and residents. He is an active member of the Association of Program Directors in Internal Medicine (APDIM)as well as a past Council member and participant in numerous committees and task forces. For the past several years he has been the leader of the Assembly of University Program Directors in that organization. In 2014, he was chosen to be featured in the APDIM Spotlight series for his role as a mentor.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Dr. Kopelman received his undergraduate degree magna cum laude in economics from Harvard College in 1970 and his medical school degree from Duke University School of Medicine in 1974. He did his house staff training at Tufts- New England Medical Center followed by a fellowship in hypertension at Massachusetts General Hospital.

His academic pursuits have been in the areas of hypertension and clinical problem solving. With Dr. Kassirer he was the co-editor of the Clinical Problem Solving series in Hospital Practice for many years and subsequently co-authored two editions of Learning Clinical Reasoning with Drs. Kassirer and Wong. In addition to his administrative responsibilities Dr. Kopelman maintains an active practice in general internal medicine and for the past several years has been regularly listed in the Best Doctors in America and by Boston Magazine in its lists of top physicians. In 2010, he received the Tufts University School of Medicine Distinguished Faculty Award.

Allison Ankeny, JD, MPH Allison Ankeny, JD, MPH is the Director for the Department of Medicine and Cancer Center at Tufts Medical Center, an Assistant Professor of Medicine at Tufts University School of Medicine, and has a secondary appointment as an Assistant Professor of Medicine at Tufts University School of Public Health and Community Medicine.

Ms. Ankeny, although new to Tufts Medical Center, has become quickly integrated and is already a highly regarded member of the Tufts Medical Center team. She brings with her a wealth of experience as an accom- plished senior administrator: from overseeing Cardiology at New York University to four Divisions of Pediatrics at Columbia University (Allergy/Immunology, Rheumatology, Endocrinology and Emergency Medicine – including opening the new Pediatric Emergency Department, a 55,000 square foot state-of-the-art facility during her tenure). In Ohio, she worked at the James Cancer Institute, an NCI-designated Cancer Center at The Ohio State University, over- seeing Radiation Medicine.

Ms. Ankeny earned her law degree from Capital University Law School (2005), a Masters of Public Health from Columbia University’s Joseph Mailman School of Public Health (2013), and her Bachelor of Arts undergraduate degree magna cum laude in psychology from Kent State University in 2001.

Ms. Ankeny has been active in academic research, having served as Key Personnel and Co-Investigator on several NIH R01s (including ARRA and HRSA grants) as well as serving as the interim Nodal Administrator for the Pediatric Emergency Care Alliance Network (PECARN) – a nationwide collaboration of top-tier academic medical centers. Her research interests are varied, including the intersection of healthcare ethics, medicine, business and law.

This coming summer, Ms. Ankeny will be teaching Healthcare Organizational Structure and Behavior, and Organizational Change at Tufts School of Medicine, helping to launch what is expected to be a certificate course for 1st/4th year medical students and medical residents, in a Business Enrichment Program. In addition, Allison is active and will continue to be instrumental in overseeing Tufts University School of Medicine’s MD/MBA students in departmental projects relating to health care strategy, policy, and quality/process improvements.

Danielle Riggs, BS Danielle Riggs joined the Department of Medicine administrative leadership team in the fall of 2008 as the Director of Research Administration. She oversees the pre- and post-award administration for all federal, foundation, and industry grant funds and clinical trials across the Divisions of Medicine. She was previously the Director of Administration and Finance for the Molecular Oncology Research Institute and Associate Director of Finance for the Tufts Cancer Center, where she helped grow the cancer research program. Danielle holds a bachelor’s degree from Stonehill College.

9 CLINICAL ACTIVITY

The Department’s clinical revenue base is derived from several sources: in-patient daily care and consults, outpatient care, procedures, and certain off-site revenue for clinical activities. The Department is organized as part of Tufts Medical Center Physician Organization as Pratt Medical Group. The table below shows the inpatient volumes for the Department of Medicine at Tufts Medical Center. Overall, total Medicine inpatient discharges decreased by 12.3% from FY13 to FY14. Inpatient Activity at Tufts Medical Center

Attending Service Fiscal Year 2013 Actual Fiscal Year 2014 Actual % Change Cardiology 2,075 1,802 -13.2% Gastroenterology 673 633 -5.9% Internal Medicine and Adult 981 759 -22.6% Primary Care Geographic Medicine and 636 556 -12.6% Infectious Disease Hematology/Oncology 935 888 -5.0% Nephrology 1,153 1,008 -12.6% Pulmonary, Critical Care and 845 768 -9.1% Sleep Medicine Geriatrics 652 558 -14.4% Grand Totals 7,950 6,972 -12.3%

The table below outlines the outpatient visit volumes for the Department of Medicine at Tufts Medical Center. Ambulatory visits increased by 5.9% from FY13 to FY14. Outpatient Activity at Tufts Medical Center

Division Fiscal Year 2013 Actual Fiscal Year 2014 Actual % Change Cardiology 11,565 12,285 6.2% Endocrine 6,521 7,190 10.2% Gastroenterology 6,422 7,240 12.7% Primary Care – Boston (GMA) 65,982 66,838 1.3% Primary Care – Quincy 1,664 3,843 130.9% Primary Care – Framingham n/a 754 n/a Geographic Medicine and 4,771 4,970 4.17% Infectious Disease GI/Nutrition-Obesity Clinic 93 143 53.7% Hematology/Oncology 6,323 6,692 5.8% Nephrology 5,174 5,271 1.8% Pulmonary, Critical Care and 4,521 4,827 6.7% Sleep Medicine Rheumatology 6,075 6,031 -0.7% Grand Totals 119,111 126,084 5.9%

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Clinical professional revenue has grown by 11.6% between FY 2013 and FY 2014, as shown below. Clinical Professional Revenue

Division Fiscal Year 2013 Actual Fiscal Year 2014 Actual % Change Cardiology 6,659,911 6,999,658 5.1% Endocrine 912,745 1,065,879 16.8% Gastroenterology 2,955,358 3,557,783 20.4% General Internal Medicine (includes all 8,338,031 8,907,439 6.8% Primary Care sites) Geographic Medicine and Infectious 2,450,050 2,589,657 5.7% Disease GI/Nutrition-Obesity Clinic 58,493 76,126 30.1% Hematology/Oncology 2,372,623 2,597,898 9.5% Nephrology 3,199,977 3,148,033 -1.6% Pulmonary, Critical Care and Sleep 2,490,144 2,978,927 19.6% Medicine Rheumatology 828,926 868,401 4.8% Grand Totals 30,265,121 33,767,428 11.6%

RESEARCH ACTIVITY The Department of Medicine has a wide variety of clinical and basic research programs. Most basic research is conducted in the Tupper Research Institute, whereas clinical research programs are based primarily at 35 Kneeland Street and in Tufts Medical Center. Many members of the Department of Medicine conduct their research within the Molecular Cardiology Research Institute (located on 7 floors of the Tupper Building), the Molecular Oncology Research Institute (located on 3 floors at 75 Kneeland Street), and the Institute for Clinical Research and Health Policy Studies (located at 35 Kneeland Street). Each of these research-focused institutes has close ties with the Department of Medicine.

The table below summarizes the grant and contract activity across the Divisions and Institutes in FY 2014, with increase/ decreases from the prior year noted in parentheses. Further specific details are shown in the individual Division/ Institute reports.

2014 Research Awards 1

Division R Series K Series U Awards Training Contracts Foundation Clinical 2 (incl. (incl. Grants & Sub- & Internal Trials supplements) supplements) (iT & F series) contracts Grants

Cardiology 1 (0) 0 (0) 0 (0) 0 (0) 7 (0) 0 (0) 24 (-4) Clinical Decision Making 1 (0) 0 (0) 0 (0) 0 (0) 4 (-2) 0 (0) N/A Endocrinology 1 (0) 0 (0) 1 (0) 0 (0) 0 (0) 2 (0) 1 (-2) Gastroenterology 2 (0) 1 (0) 0 (0) 0 (0) 2 (+1) 3 (0) 9 (-3) Geographic Medicine and 5 (-4) 2 (-2) 1 (+1) 2 (-2) 8 (-9) 3 (-2) 16 (-3) Infectious Disease Internal Medicine & Adult 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 2 (0) 0 (0) Primary Care Hematology/Oncology & 2 (+2) 0 (0) 0 (0) 1 (0) 2 (+1) 0 (-2) 43 (-6) Cancer Center Nephrology 6 (+1) 0 (-3) 1 (0) 2 (+1) 9 (-1) 3 (-1) 14 (+2)

11 RESEARCH ACTIVITY (continued)

Division R Series K Series U Awards Training Contracts Foundation Clinical 2 (incl. (incl. Grants & Sub- & Internal Trials supplements) supplements) (iT & F series) contracts Grants

Pulmonary 2 (-1) 0 (0) 0 (0) 0 (0) 3 (-1) 0 (0) 26 (-4) Rheumatology 4 (0) 2 (0) 1 (+1) 0 (0) 1 (-3) 1 (-1) 8 (+4) Institute for Clinical Research and Health 5 (0) 0(-1) 2 (+1) 1 (-1) 40 (-7) 21 (-26) N/A Policy Studies Molecular Cardiology 13 (-13) 1 (0) 0 (0) 1 (0) 12 (+6) 14 (+2) N/A Research Institute Molecular Oncology 14 (-4) 1 (+1) 2 (0) 0 (0) 7 (-2) 12 (-2) N/A Research Institute

1Support from the National Institutes of Health constitutes the major source of funding for the Department of Medicine. The table above is a summary of the number of individual active Grants & Contracts and Clinical Trials awards for the Department of Medicine as of the close of 2014. 2Clinical Trial numbers reflect trials with activity during the fiscal year (not # of executed agreements).

FY 14 Total Grants and Contracts Revenue ($36M)

$7,000

) $6,000

$5,000

(in thousands $4,000

$3,000

$2,000

$1,000

$0 e GI C y y S /C CDM ology MCRI MORI diology ICRHP Car Endocrin Pulmonar GeoMed/ID HemOnc Nephr Rheumatolog FY 14 Revenue Sources

12%

13% Federal Foundation/Other 75% Corporate

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 THE INTERNAL MEDICINE TRAINING PROGRAM

The internal medicine training program at Tufts Medical Center attracts superior applicants from medical schools across the United States. Each year, 24 interns are recruited from a pool of over 2,000 applicants with diverse backgrounds, talents and aspirations. The program is unusual for the configuration of the ward services along subspecialty lines. The hospital has a strong primary care referral base as well as many well-known subspecialists, which results in a diverse population of patients with unusual as well as common illnesses. House officers are supervised and taught by attending physicians with exceptional expertise in the subspecialties of interest. Many graduates become primary care physicians. Others, who seek subspecialty training, match with excellent fellowship programs. Over the upcoming year, the program will add two tracks, one a business track and the other a combined medical education track in conjunction with the pediatric residency program.

13 THE DIVISIONS

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 The Department of Medicine is organized in 13 divisions. Although most fall into traditional categories, the Division of Clinical Care Research and the Division of Clinical Decision Making and Telemedicine are unusual in their scope. The Division of Geographic Medicine and Infectious Diseases signals its international interests by its name. Many of the divisions have impressive histories as can be seen in their introductory overviews.

15 DIVISION OF ALLERGY

The Allergy Division is a part of the Division of Internal Medicine and Adult Primary Care at Tufts » » DIVISION OF DIVISION Medical Center. The Division offers programs that address common conditions including allergic rhinitis, allergic asthma, eczema, food allergy, drug allergy, sinusitis, urticarial, angioedema and adult immunodeficiency. ALLERGY Division members work closely with the otolaryngology, dermatology and gastroenterology departments to coordinate the evaluation of allergic disorders that are common to those

John Ohman, MD specialties. The Food Allergy Center at Tufts Medical Center and Floating Hospital for Children was established in 2013 in collaboration with the pediatric and adult Gastroenterology Divisions. Highlights of 2014

»» Implementation of intravenous drug desensitization procedures for chemotherapy agents, collaborating with Pharmacy and Infusion Clinic.

Faculty

Name Academic Rank Special Responsibility John L. Ohman, MD, FACP Clinical Professor, Medicine Chief of Division Weihong Zheng, MD Assistant Professor, Medicine Director, Food Allergy Center John Leung, MD Assistant Professor, Medicine & Pediatrics Co-Director, Food Allergy Center at Floating Hospital for Children

Clinical Programs

The outpatient clinics provide evaluation and treatment of allergic diseases through referrals from staff physicians and from an increasing base of community physicians. A wide range of diseases are seen and evaluated. Assessment of the allergic component of asthma, chronic rhinitis, food allergy, drug allergyand eczema accounts for approximately 50% of outpatient activity. Division members also treat diverse conditions such as anaphylaxis from insect stings, other anaphylactic syndromes such as exercise induced anaphylaxis, angioedema and eosinophilic syndromes including eosinophilic esophagitis and vasculitis.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Specialized treatments are available through the Allergy Division including allergen immunotherapy for inhalant and insect sting allergy. Outpatient oral desensitization procedures have been developed for drug allergy. These procedures include desensitization to aspirin for asthmatic patients with nasal polyps.

Adult immunodeficiency is evaluated and immunoglobulin replacement treatments are administered.

Inpatient consultations for drug allergy and other allergic disorders are provided. Inpatient desensitization treatments are prescribed and monitored by the division.

The Food Allergy Center at Tufts Medical Center and Floating Hospital for Children was established in 2013, in collaboration with the pediatric and adult Gastroenterology Divisions. It provides an integrative, patient-oriented, and » » multidisciplinary care for patients with known or suspected food allergies. Through the Food Allergy Center, OF DIVISION eosinophilic esophagitis, eoinsophilic gastrointestinal disorders, celiac disease, other food intolerance syndromes are evaluated, in coordination with the GI Division.

Community Outreach Programs ALLERGY Division staff have given presentations to community health center, on local TV and radio stations about the prevention and treatment of allergic diseases. The staff reach out to the Mandarin and Cantonese speaking population of Boston through seminars and educational articles in Chinese language newspapers to increase local awareness of the services offered by the Allergy Division.

Research Support

Recipient Funding source Purpose of award The primary aims of this prospective, multi-center, longitudinal and exploratory pediatric and adult study are to determine the correlation of clinical outcome measures (patient reported outcomes, quality of life and National Institutes of Health endoscopy) with the established biomarker of peak mucosal eosinophil count (NIH) (Phase 1), and to compare the transcriptomes (eosinophilic esophagitis- transcriptome, eosinophilic gastritis-transcriptome and eosinophilic colitis- transcriptome) with their respective peak mucosal eosinophil counts and respective clinical outcome measures. Swiss National Science Foundation AstraZeneca AG (Switzerland) John Leung, MD Aptalis Dr. Falk Pharma GmbH The primary aim of this multicenter study is to develop, validate and evaluate (Germany) an eosinophilic esophagitis activity index for pediatric and adult patients. Glaxo Smith Kline AG Nestlé S. A. (Switzerland) The International Gastrointestinal Eosinophil Researchers (TIGERS) The primary aim of this multicenter, double-blind, randomized, placebo- Regeneron controlled study is to investigate the efficacy, safety, tolerability, Pharmaceuticals, Inc. pharmacokinetic, and immunogenicity of dupilumab in adult patients with eosinophilic esophagitis.

17 DIVISION OF CARDIOLOGY

The Division of Cardiology at Tufts Medical Center is a world-wide leader in patient care, research and » » DIVISION OF DIVISION education in cardiology. Under the guidance of its first chief, Dr. Herbert Levine, the Division of Cardiology developed into a Center of Excellence in each of the major subdivisions of cardiology, including clinical cardiology, cardiac catheterization and

CARDIOLOGY intervention, noninvasive cardiac imaging, and electrophysiology. Later, under the direction of Deeb Salem MD, and subsequently Marvin Konstam MD, Tufts Medical Center began a program in advanced heart failure and cardiac transplantation. Today, under the leadership of James Udelson, MD James Udelson MD, the Division of Cardiology continues to prosper. The advanced heart failure and cardiac transplantation program is the largest in New England, the Hypertrophic Cardiomyopathy (HCM) Center remains among the most active in the United States, and the cardiac catheterization, electrophysiology and cardiovascular imaging laboratories show steady growth in the number of patients served and in the use of advanced techniques.

The Division of Cardiology maintains many outreach programs across New England. Attending physicians provide cardiovascular expertise to numerous regional sites. Cardiology fellows spend time at neighboring institutions to complement their training. In addition, visiting students, residents, fellows and attending staff from other institutions spend time at Tufts Medical Center to learn the latest techniques in cardiovascular care.

Cardiologists at Tufts Medical Center participate in a wide variety of clinical, translational and basic science research projects sponsored by the NIH, industry, and other sources. There is extensive collaboration and shared faculty with the Molecular Cardiology Research Institute. Clinical trials are underway to study improved techniques for percutaneous interventions, ventricular assist devices, automated external defibrillators, nuclear imaging for assessment of infarct viability and remodeling, approaches to the assessment of vascular function, and novel therapies for atherosclerosis.

Teaching at all levels remains a strong part of the Division’s academic mission. All faculty are involved in bedside and didactic teaching as well as serving as education and research mentors. The Division of Cardiology is consistently rated amongst the highest for teaching Tufts University students and house officers. In addition, fellows take great pride in teaching residents and students. Highlights of 2014

»» Largest cardiac transplantation and ventricular assist programs in the New England region

»» The busiest Hypertrophic Cardiomyopathy Center in the Northeast, including surgical myectomies

»» Growing referral network for complex catheter-based coronary, structural, heart failure and electrophysiology procedures

»» Growth of multi-disciplinary transcutaneous aortic valve replacement (TAVR) program

»» Superior graduate medical educational training in all disciplines of cardiovascular medicine

»» Outpatient community outreach within the model of the distributed academic medical center

»» Numerous Tufts Medical Center cardiologists listed as Boston Magazine’s 2014 Top Doctors

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Interest » » Marvin Konstam, MD Professor Chief Physician Executive, Cardiovascular Center OF DIVISION Chief, Division of Cardiology James Udelson, MD Professor Director, Nuclear Cardiology Assistant Clinical James Alderman, MD Interventional Cardiology, Heart Center of MetroWest CARDIOLOGY Professor Assistant Clinical Elizabeth Ascher, MD General Cardiology, Heart Center of MetroWest Professor Molecular Cardiology Research Center Associate Program Director, Cardiovascular Education and Robert Blanton, MD Assistant Professor Fellowship Training Director, Preventive Cardiology

Patrick Blomberg, MD Assistant Professor Electrophysiology, Heart Center of MetroWest

Assistant Clinical William Castelli, MD General Cardiology, Heart Center of MetroWest Professor

Laurence Conway, MD Assistant Professor Interventional Cardiology

Gregory Corrodi, MD Assistant Professor Cardiovascular Imaging Assistant Clinical Eric Davidson, MD Cardiovascular Imaging, Heart Center of MetroWest Professor Medical Director, Cardiac Transplantation Program; Medical David DeNofrio, MD Associate Professor Director, Cardiomyopathy Center Program Director, Advanced Heart Failure Fellowship Brian Downey, MD Assistant Professor General Cardiology, Cardiovascular Imaging Mohamad El-Zaru, MD Assistant Professor Interventional Cardiology

N. A. Mark Estes, MD Professor Director, Cardiac Electrophysiology

Solomon Gabbay, MD Assistant Professor General Cardiology Jonas Galper, MD, PhD Professor Molecular Cardiology Research Center Assistant Clinical Christopher Gange, MD Interventional Cardiology, Heart Center of MetroWest Professor Assistant Clinical Harvey Goldfine, MD Cardiovascular Imaging, Heart Center of MetroWest Professor Jessica Haffajee, MD Assistant Professor General Cardiology, Norwood Director, Electrophysiology Fellowship Program; Director, Tufts Munther Homoud, MD Associate Professor University School of Medicine Cardiac Pathophysiology Course Gordon Huggins, MD Associate Professor Molecular Cardiology Research Center Iris Jaffe, MD, PhD Associate Professor Co-Director, Molecular Cardiology Research Center

19 Faculty (continued)

Name Academic Rank Title and Special Interest Assistant Director, Interventional Cardiology; Director, Acute Circulatory Support Program; Director, Surgical Research Navin Kapur, MD Assistant Professor Laboratory – Interventional Division Investigator, Molecular Cardiology Research Institute Elisa Kent Mendelsohn Professor of Molecular Medicine, Tufts University School of Medicine »

» Chief Scientific Officer DIVISION OF DIVISION Richard Karas, MD, PhD Professor Executive Director, Molecular Cardiology Research Institute Vice-Chairman of Medicine Co-Director, Women’s Heart Center

CARDIOLOGY Michael Kiernan, MD Assistant Professor Medical Director, Ventricular Assist Device Program Director, Cardiac Catheterization Laboratory Carey Kimmelstiel, MD Associate Professor Director, Interventional Cardiology Fellowship Program Assistant Clinical George Kinzfogl III, MD Cardiovascular Imaging, Heart Center of MetroWest Professor Alan Kono, MD Assistant Professor Heart Failure Associate Chief of Cardiology Associate Chief Medical Officer for GME Director, Cardiovascular Jeffrey Kuvin, MD Associate Professor Education and Fellowship Training Co-Director, Center for Adults with Congenital Heart Disease Douglas Laidlaw, MD Assistant Professor Cardiac Electrophysiology Director, Heart Station; Co-Director Hypertrophic Mark Link, MD Professor Cardiomyopathy Center Assistant Clinical Donald Love Electrophysiology, Heart Center of MetroWest Professor Anthony Marks, MD Assistant Professor Interventional Cardiology Director, Hypertrophic Cardiomyopathy Center; Co-Director, Martin Maron, MD Assistant Professor Cardiovascular CT and MRI Nicole Orr, MD Instructor General Cardiology, Norwood Director, Valve Clinic; Director, Cardiovascular Ultrasound Natesa Pandian, MD Professor Research; Co-Director, Comprehensive Cardiovascular Imaging Director, Cardiovascular Imaging Center; Director, Ayan Patel, MD Professor Echocardiography Laboratory; Director, Women’s Heart Center Stephen Pauker, MD Professor General Cardiology Yuheng Ruan, MD Assistant Professor General Cardiology, Cardiovascular Imaging Deeb Salem, MD Professor Chairman of Medicine

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Name Academic Rank Title and Special Interest Gordon Saperia, MD Assistant Professor General Cardiology Sushil Singh, MD Assistant Professor Cardiac Electrophysiology Jeffrey Shih, MD Assistant Professor Heart Failure Assistant Clinical Howard Sussman, MD General Cardiology, Heart Center of MetroWest Professor »

David Venesy, MD Assistant Professor Heart Failure » DIVISION OF DIVISION Jonathan Weinstock, MD Assistant Professor Director, Cardiac Rhythm Management Devices Medical Director, Cardiac Care Unit Medical Director, Valve and Structural Heart Health Center Andrew Weintraub, MD Assistant Professor Associate Director, Cardiac Catheterization Laboratory Associate CARDIOLOGY Director, Vascular Medicine Center Assistant Clinical David Young, MD General Cardiology, Heart Center of MetroWest Professor

Major Clinical Programs The Division of Cardiology at Tufts Medical Center remains committed to the academic missions of excellence in patient care, research and teaching. The following are the major clinical programs in Cardiology:

»» The Interventional Cardiology Program »» The New England Cardiac Arrhythmia Center »» The Heart Failure and Cardiac Transplant Center »» The Comprehensive Cardiovascular Imaging Center »» The Hypertrophic Cardiomyopathy (HCM) Center »» The Preventive Cardiology Center »» The Women’s Heart Center »» The Heart Station

These clinical programs are among the premier cardiovascular programs throughout the country. This report summarizes the Division’s clinical activities and recent program developments, as well as the academic growth.

The Interventional Cardiology Program

Carey Kimmelstiel, MD – Director The nationally-renowned Interventional Cardiology Program provides advanced technologies and therapies for patients with cardiovascular disease. The Interventional Cardiology staff regularly perform state-of-the-art procedures such as septal ablation for hypertrophic cardiomyopathy (HCM), valvuloplasty, catheter based valve replacement, percutaneous mechanical support for high risk coronary intervention and adv anced heart failure. The program also offers transcatheter treatment of a variety of congenital defects such as patent foramen ovale, and atrial septal defects, as well as endovascular treatment of peripheral arterial disease and aortic coarctation. In recognition of its ongoing programmatic excellence, the Tufts Medical Center Interventional Cardiology Program has, over the past five years, received continuous funding for their trainees from national societies and corporate sources.

The Interventional Cardiology Program participates in major multi-center clinical trials as well as in investigator- initiated research. In the past year, the laboratory has continued to recruit patients into trials of newer-generation drug-eluting stents as well as pharmacologic studies examining the impact of adjunctive therapies on platelet function. The interventional research staff has received accolades for the scope and quality of their enrollment efforts. Examples of this type of investigation include Dr. Carey Kimmelstiel’s collaboration with Dr. David Thaler, of the Department of Neurology, which led to data documenting a significant reduction in migraine symptoms in patients who underwent

21 closure of a patent foramen ovale. This collaboration led to the Tufts Medical Center being the third highest enroller in the ground-breaking RESPECT trial with Dr. Kimmelstiel being the highest volume implanter of PFO closure devices in the entire study. The same group has continued this line of Investigation and Is among the highest enrolling centers in the REDUCE trial - a multicenter, international study again focusing on assessing stroke reduction following PFO closure utilizing the Gore HELEX occluder. Drs. Kimmelstiel, Kapur and Weintraub have recently collaborated with basic scientists in the Tufts Molecular Oncology Research Institute in a mechanistic study which has defined the anti- platelet effects of bivalirudin specifically elucidating the inhibitory effect of this drug on platelet thrombin receptors. They have recently completed a single-center study of the differential effects of two thienopyridines on platelet aggregation in bivalirudin-treated patients. » » DIVISION OF DIVISION The Hypertrophic Cardiomyopathy Center provides a large number of physiologic studies for HCM and alcohol septal ablation. Several current studies involving alcohol septal ablation allow collaboration between the interventional staff and colleagues in the heart failure arena. In addition, Drs. Kimmelstiel, Kapur and Weintraub are initiating their participation Is a clinical study assessing the effect of percutaneous mitral valve repair in heart failure patients with CARDIOLOGY functional mitral regurgitation.

Dr. Navin Kapur directs the acute circulatory support program at Tufts, which focuses on the clinical application of percutaneous mechanical support devices (pMSD) for cardogenic shock and advanced heart failure. As a dual board- certified interventional cardiologist and advanced heart failure/transplant specialist, Dr. Kapur has developd a combined training pathway option for fellows to become Interventional Heart Failure (IHF) specialists. Since 2009, this IHF pathway has grown in reputation and Tufts Medical Center has established an international presence through the SCAI, AHA, TCT, CRF, ACC, and ESC as a leader in the field of interventional therapies for heart failure. Tufts has become a highly sought after program to participate in clinical trials evaluating interventional devices for heart failure. Tufts Medical Center was one of only 15 sites in the US involved in the Recover Right Trial investigating a pMSD designed for right ventricular failure. Tufts is also the only site in Boston participating in the PARACHUTE IV Trial evaluating a novel interventional device for apical left ventricular aneurysms and was recently invited to participate in the COAPT trial evaluating the Mitra-clip devices for functional mitral regurgiation in heart failure. Through collaborations with the division of Cardiac Surgery, Heart Failure, and several industry partners, the catheterization laboratory is developing novel approaches to diagnosis and management of percutaneously and surgically implanted cardiac assist devices. Dr. Kapur is also Director of the Interventional Division of the Surgical Research Laboratories and an Investigator at the Molecular Cardiology Research Institute (MCRI). Dr. Kapur's NIH-funded molecular research laboratory focuses on basic and translational research involving angiogenic peptides and molecular remodeling in heart failure. Since 2010, multiple international, national presentations, publications, and four patents have been submitted from Dr. Kapur’s laboratory. The Kapur Lab also has established important funded research projects with several industry leaders in the field of pMSDs (Cardiac Assist, Heartware, Thoratec, and Abiomed).

The Interventional Cardiology Training Program at Tufts Medical Center has received consecutive Fellow in-Training Grant Awards from the SCAI and Abbott Industries for excellence in fellow education since 2009. The laboratory participates in benchmarking outcomes with the American College of Cardiology and the National Catheterization Data Registry. This allows the Division to compare its interventional outcomes with those of other programs throughout the country and fosters a high standard of quality.

Dr. Andrew Weintraub, Associate Director of the Cardiac Catheterization Laboratory and the Director of the Coronary Care Unit, supervises the diagnostic and therapeutic services offered to patients with lower and upper extremity vascular disease, carotid artery disease, and hypertension secondary to renal artery stenosis. The program offers care for patients with claudication and critical limb ischemia. Together with vascular surgery, the Cardiac Catheterization Laboratory is participating in investigation of a novel arterial access closure device. In addition, Dr. Weintraub has designed a trial to estimate the size of vessels in a novel and precise manner. He served as the site investigator for a clinical trial studying the effect of a cardiac device on infarct size in patient suffering from ST elevation myocardial infarction. Tufts Medical Center was the third leading enrolling site in the United States. The interventional cardiology service also participates in the multi-disciplinary Valvular and Structural Heart Health Center. This service evaluates patients with valvular and structural heart disease who are considered high risk for conventional surgical procedures. This service integrates multi-modality testing and state of the art therapies for these exceptional risk patients.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Dr. Kimmelstiel is active in clinical trials and he serves on many safety monitoring committees. The Tufts Medical Center Catheterization Laboratory is expanding the interventional device trials to include newer PFO closure devices, left atrial appendage closure devices and bio-reabsorbable stenting platforms. In addition, Dr. Kimmelstiel has been the local leader in numerous industry-sponsored coronary disease studies. He has recently completed a single-center study documenting previously un-described anti-platelet effects of bivalirudin. He has recently served as national principle investigator of a large drug-eluting stenting trial.

The New England Cardiac Arrhythmia Center

N. A. Mark Estes, MD – Director » » The New England Cardiac Arrhythmia Center offers outpatient consultative services for patients with arrhythmias and OF DIVISION conducts research on arrhythmias. The Center is staffed by five full time and four visiting board-certified electrophysiologists. Physicians and staff provide comprehensive evaluation and management of patients with cardiac arrhythmia with an emphasis on communicating timely with patients and members of the health care team. Nurse practitioners respond to routine patient inquiries and educational needs. Daily outpatient pacemaker and implantable CARDIOLOGY cardioverter defibrillator clinics are available for those with implantable devices. The Center provides trans-telephonic monitoring of pacemakers and loop monitors.

Three cardiac electrophysiology laboratories provide the full spectrum of invasive electrophysiology studies, radiofrequency ablations, defibrillator and pacemaker implantations, tilt table tests, and cardioversions. Two ablation laboratories provide the most advanced imaging and mapping capabilities to address supraventricular arrhythmias and many ventricular arrhythmias. With the advanced mapping system, more radiofrequency ablation cases are being referred for cure of supraventricular and ventricular arrhythmias as well as atrial fibrillation.

The staff electrophysiologists oversee a fellowship program consisting of three fellows in clinical cardiac electrophysiology. Members of the Arrhythmia Center have served on guidelines writing groups and held leadership positions in national and international professional organizations. The fellows routinely present abstracts at national meetings and the attendings serve as invited faculty at the major national and international meetings.

Staff electrophysiologists participate extensively In clinical research. The EP attendings have participated on the Executive Committees and as Principal Investigators on the major cardiac rhythm device trials including the CABG Patch, DEFINITE, MADIT II, MADIT-CRT,MADIT-RIT, and MADIT Diabetes Trials as well as the NIH-funded “Multidisciplinary Study of Right Ventricular Dysplasia” (ARVD). This last-named trial is a multidisciplinary, multi- center, study of the cardiac, clinical, and genetic aspects of arrhythmogenic right ventricular dysplasia (ARVD). Dr. Estes conducts research on the prevention of sudden death by means of Automated External Defibrillators (AEDs) with several publications related to program development, clinical utility, legislative policy, and legal risks of the devices.

Dr. Mark Link's research into sudden death from chest wall impact (commotio cordis) has advanced efforts to prevent sudden deaths resulting from precordial chest blows. Over 30 publications have been produced recently from this laboratory. Together with colleagues in the Tufts-MCRI, he performs electrophysiologic investigations on knock-out mouse models. He is investigating the association between air pollution and atrial and ventricular arrhythmias. He also investigates arrhythmias in patients with Hypertrophic Cardiomyopathy. Dr Link is a member of the 2015 AHA Writing Group for Advanced Cardiac Life Support (ACLS) Guidelines, as well as the Writing Committee for the 2011 AHA Hypertrophic Cardiomyopathy Guidelines and 2012 AHA PPM and ICD Implant Guidelines. Dr. Link is also the principal investigator of the RAID trial, assessing the efficacy of ranolazine in prevention of ICD shock. Dr. Weinstock served as the principal investigator in the Replace Trial and is serving in a similar role in the ongoing Echo CRT and VEST Trials.

The Heart Failure and Cardiac Transplant Center

David DeNofrio, MD – Director The Heart Failure and Cardiac Transplant Center is nationally renowned for its clinical and research activities. The Center Is a regional leader in therapies for severe heart failure, including cardiac transplantation and mechanical ventricular assist device therapy.

23 The Center’s cardiac transplantation program performed 24 transplant procedures in the 2014 calendar year. Additionally, over the last five-year period, the program has been the highest volume cardiac transplantation center in New England, having performed 94 procedures. Following approval by the Center for Medicare and Medicaid Services (CMS) in 2001, the transplant program has met or exceeded CMS thresholds each year for both transplant volume and outcomes. With a steady stream of new referrals for transplantation, the program performs over 100 formal transplant evaluations per year.

The Center also maintains a vibrant mechanical ventricular assist device program to support patients with Stage D heart failure. Since 1998 over 325 patients have been supported using ventricular assist devices for both “bridge-to- transplantation” and “destination therapy” indications. Following the approval by CMS of the left ventricular assist » » DIVISION OF DIVISION device (LVAD) program in 2003, a steadily increasing number of procedures have been performed under this new indication. The two main LVADs that are employed at this institution are the Thoratec HeartMate II and the HeartWare HVAD devices. The HeartWare device is currently under investigation and Tufts Medical Center was the first center In the Northeast to use this pump for permanent therapy. In 2014, 56 LVADs were placed for the treatment of Stage D heart CARDIOLOGY failure, the greatest number since the program’s inception.

The Division maintains heart failure outreach programs at Lahey Clinic, Rhode Island Hospital, the University of Massachusetts Medical Center and Dartmouth Hitchcock Medical Center. In addition, cardiologists from Lahey Clinic, Dartmouth-Hitchcock, Beth Israel Deaconess Medical Center, University of Massachusetts Medical Center and Rhode Island Hospital participate in the inpatient and outpatient services at Tufts Medical Center. Cardiovascular fellows from a variety of neighboring institutions spend time at Tufts Medical Center to learn more about the management of advanced heart failure. The Advanced Heart Failure and Transplant Cardiology Fellowship Program is one of only a limited number or programs in the country receive ACGME accreditation for its heart failure training.

The Center participates in several clinical research investigations of new therapies for the treatment of all stages of heart failure as well as new immunosuppressive agents for heart transplantation. The Center has been an active study site for the National Heart and Lung Institute’s Heart Failure Clinical Trials Network and is currently engaged in multiple Network protocols. The FIGHT trial is evaluating a novel therapeutic approach to stabilize acute heart failure syndromes at the time of transition from hospital to home. Liraglutide is a glucagon-like-peptide 1 (GLP-1) receptor agonist. The Network is investigating the hypothesis that liraglutide will improve metabolism in energy depleted cardiomyocytes and help to reduce heart failure rehospitalizations. The ATHENA trial is examining spironolactone, a standard heart failure medication for patients with chronic, stable heart failure. The role of spironolactone in the treatment of acutely decompensated heart failure has not yet been studied. ATHENA will investigate the hypothesis that high-dose spironolactone may be beneficial in patients with acute heart failure and may augment effective diuresis. In addition, the Center is participating in the CTOT-11 trial examining the efficacy of rituximab in preventing the development of allograft coronary disease In heart transplant recipients. The development of premature coronary disease has been a major limitation to long-term survival following heart transplantation. CTOT-11 is sponsored by the National Heart, Lung and Blood Institute. Finally, the group is collaborating with Amgen on a retrospective study to evaluate the costs associated with heart failure hospitalizations and re-hospitalizations.

The CardioVascular Imaging Center: The Cardiovascular Imaging and Hemodynamic Laboratory (Echocardiography Lab)

Ayan R. Patel, MD – Director This laboratory is nationally known for its innovative approaches to cardiac diagnosis and has made major advances in the echocardiographic and Doppler assessment of myocardial, valvular, congenital, and ischemic heart disease. Dr. Natesa Pandian, Director of Cardiovascular Ultrasound Research, is internationally renowned for echocardiography- related research studies and lectures at educational seminars worldwide. Dr. Patel has extensive experience in the conduct of echocardiography-related research.

The Laboratory provides a unique array of advanced services including: three-dimensional transthoracic and transesophageal imaging; stress echocardiography for specialized evaluation of heart failure, valvular disease, cardiac hemodynamics and assessment of ischemia; it also uses myocardial contrast imaging for evaluation of cardiac function.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 The clinical research activities of the laboratory include three-dimensional assessment of cardiac chambers and the relationship with hemodynamics, investigation of three-dimensional speckle tracking for evaluation of cardiac disease, the use of imaging for evaluation of valvular disease, and vascular ultrasound assessment of peripheral vascular endothelial function. Fellows play an integral role in the clinical and research activities of the laboratory.

Nuclear Cardiology Laboratory

James Udelson, MD – Director Clinical imaging interpretation in this laboratory routinely is performed using 4DM-SPECT software, providing readers with fully quantitative analysis to support image interpretations. The lab is accredited by ICANL (Intersocietal » » Commission on the Accreditation of Nuclear Laboratories). OF DIVISION

The Cardiac Imaging Core Laboratory completed work on the multi-center NHLBI-funded Occluded Artery Trial ancillary nuclear study (OAT-NUC), in which patients from the parent OAT trial underwent SPECT imaging for assessment of infarct zone viability and influence on remodeling. The IMMEDIATE Trial assessed infarct size from CARDIOLOGY SPECT imaging in a subset of the patients enrolled in the NHLBI study of glucose-insulin-potassium given to patients with acute coronary syndromes in ambulances. The Core Lab also serves as a central quality control and analysis center for SPECT imaging performed in conjunction with 2 major federally-funded comparative effectiveness trials - the PROMISE trial, randomizing 10,000 patients with suspected CAD to an initial evaluation with functional testing (including stress SPECT perfusion imaging) or to an anatomic evaluation strategy (CT angiography), and RESCUE, a 4,000 patient trial of those with suspected CAD randomized to an initial evaluation with stress SPECT perfusion imaging or to CT angiography.

Cardiac Computed Tomography and Magnetic Resonance Imaging

Martin Maron, MD, Kent Yucel, MD and Neil Halin, DO – Co-Directors At Tufts Medical Center, a complete non-invasive assessment of the coronary arteries is performed with a 10- second breath hold without the need for beta-blockers with the use of the 64-slice Siemens Definition dual source scanner. In addition, Tufts Medical Center has two Phillips MRI magnets capable of the most advanced cardiac imaging. The cardiac MRI program focuses on imaging for cardiomyopathies as well as structure/function and myocardial viability. Fellows participate in all aspects of advanced imaging, including image acquisition and analysis.

The Hypertrophic Cardiomyopathy Center

Martin S. Maron, MD - Director; Mark Link, MD, James E. Udelson, MD – Co-Directors 2014 marks the thirteenth year of the first comprehensive Hypertrophic Cardiomyopathy (HCM) Center in the Northeast. The Center provides state-of-the-art diagnostic and therapeutic modalities for patients with HCM, the most common genetic cardiovascular disease. The HCM center utilizes traditional imaging techniques and advanced cardiac imaging techniques to accurately assess the extent of disease as well as to determine optimal treatment. Surgeons working with the HCM center perform close to 60 surgical myectomies per year for relief of left ventricular outflow obstruction. The Division’s interventional cardiology team was the first in the Boston area to perform an alcohol septal ablation for relief of heart failure symptoms in patients with obstructive HCM and is a leader in this area. The HCM Center’s cardiologists provide multidisciplinary patient care for problems as diverse as heart failure, syncope, arrhythmias and prevention of sudden death.

The Center is a major research center for patients with HCM. Dr. Martin Maron recently completed a major multicenter study demonstrating that the amount of fibrosis detected by MRI is a novel risk marker for predicting future sudden death in patients with this disease. Members of the Center have contributed to the current understanding of HCM through their work on exertional ischemia, the use of implantable cardioverter defibrillators (ICD) to prevent sudden death, the role of left ventricular outflow tract obstruction to prognosis, and the use of cardiac MRI in diagnosis and prognosis. To date, over 100 manuscripts have been published from the HCM center at Tufts. The center has become established as one of the top HCM centers in the country.

25 The Preventive Cardiology Center

Robert M Blanton, MD – Director The Preventive Cardiology Center (PCC) provides risk factor assessment and management for patients with heart disease and those at an increased risk for cardiovascular disorders. The staff is composed of a multi-disciplinary team of cardiologists, fellows, pharmacists, and other health professionals. Staff members have instituted a number of new measures to enhance patients’ medication compliance.

The Center functions as the primary outpatient training experience for cardiovascular fellows at Tufts Medical Center. Numerous clinical research projects are based in the PCC, including the evaluation of vascular endothelial function to » »

DIVISION OF DIVISION assess cardiovascular risk. The Vascular Function Study Group is a research team focused on preventive cardiology and is comprised on physicians, scientists, nurses, house officers and students. This group performs translational research focusing on surrogate markers of vascular endothelial function in a variety of patient populations. The group also participates in multi-center research projects focused on lipids and other novel prevention therapies. The team was one

CARDIOLOGY of the top enrolling centers for the IMPROVE-IT Study, a multi-center, multi-national study examining ultra-low LDL levels in patients at risk for atherosclerosis, and STABILITY, a study focusing on a novel anti-inflammatory mechanism to treat coronary artery disease. The group has also participated in novel lipid-altering research with PCSK9 Inhibition, and currently is enrolling patients for the ongoing ODYSSEY OUTCOMES study to test the effect of additional lipid lowering with the PCSK9 inhibitor alirocumab in patients with prior acute coronary syndrome. An additional ongoing study enrolling patients through PCC is CAMELLIA-TIMI61, which seeks to evaluate the effect of long-term treatment with Belviq (lorcaserin) on the incidence of major adverse cardiovascular events in obese and overweight subjects with cardiovascular disease or multiple cardiovascular risk factors.

The Women’s Heart Center

Ayan R. Patel, MD – Director The goal of the Women’s Heart Center is to provide consultative support to primary physicians, as well as to cardiologists, regarding prevention, diagnosis, and management of cardiovascular diseases in women. The center consists of a team of physicians with expertise in the management of lipid disorders and other cardiovascular risk factors, management of cardiac arrhythmias, and cardiovascular imaging/diagnostic testing in women. Nutritional counseling is also available in collaboration with the Frances Stern Nutrition Center. Dr. Richard Karas (Co-Director) and Dr. Ayan Patel have had a long-standing research interest in vascular health in women and Dr. Karas is internationally recognized as an expert on the effects of estrogen on the vasculature.

The Heart Station

Mark Link, MD – Director The Heart Station is the epicenter for cardiovascular testing for electrocardiography and arrhythmia monitors. The Heart Station performed nearly 30,000 electrocardiograms amongst a variety of other cardiovascular tests, such as Holter and loop monitors, and cardiopulmonary stress tests.

Teaching Activities

Jeffrey Kuvin, MD-Director, Cardiovascular Education and Fellowship Training The Division of Cardiology is dedicated to the highest level of teaching and training of medical students, house staff and fellows. Members of the Division participate in all aspects of teaching, including didactic lectures, bedside diagnosis, small group discussions, and other interactive methods of teaching at all levels.

Cardiology faculty are involved with individual preceptorships and "selectives" with first year medical students. In addition, attending cardiologists teach small group lecture series on topics in cardiology. Faculty provide didactic courses on the cardiovascular physical examination and also provide research mentorship to students throughout their medical school years. Cardiology fellows work with students as they learn physical diagnosis.

Under the direction of Munther Homoud, MD, the cardiovascular pathophysiology course for second year Tufts medical students is a comprehensive series of lectures and small group discussions. Cardiology staff and fellows are involved in

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 teaching third students and fourth year medical sub-interns on inpatient ward services and in the outpatient setting. Cardiology fellows also teach a weekly lecture on electrocardiography and mentor students on clinical rotations.

Bedside and didactic teaching of internal medicine house officers occurs daily during attending rounds as well as dedicated teaching conferences. Numerous attending cardiologists have received recognition for outstanding teaching by the house staff. In addition, fellows are encouraged to attend conferences and to conduct research within the Division. Numerous house officers present research at national research meetings and publish articles in the field.

Cardiovascular fellowship training and education at Tufts Medical Center is under the direction of Jeffrey Kuvin, MD. Dr. Kuvin is also the Medical Center's Associate Chief Medical Officer for Graduate Medical Education. In this role, he »

oversees all of the hospital's ACGME-approved training programs. Dr. Robert Blanton is the Associate Director of the » DIVISION OF DIVISION Fellowship Program and Candace Scanlon is the Education Coordinator. Fellowship positions remain extremely competitive. The three-to-four year fellowship program provides advanced training in all aspects of cardiovascular disease. Fellows participate in research within the Division, from basic science to translational and clinical projects. All

fellows participate in an annual research proposal competition. In addition, fellows present findings at regional and CARDIOLOGY national meetings and publish their work in peer-reviewed journals. Graduating fellows from the Division of Cardiology move on to successful careers in all aspects of academic and clinical cardiology.

Research Grant Support

Recipient Funding Source Purpose of award “Cardiac Myocyte-Specific Role of PKG I Alpha in Aging- NIH – Institute of Aging Dependent Cardiac Remodeling” ACC/ASP Geriatric Robert Blanton, MD Chief, Division of Cardiology Cardiology Career Director, Nuclear Cardiology Development Award NIH “Identifying Heart-Specific Anti-Remodeling Molecules” Amgen Acute Heart Failure Database David DeNofrio, MD NHLBI/NIAID COTO-11 Transplant Trial

N. A. Estes, MD NIH Multidisciplinary Study of Right Ventricular Cardiomyopathy

Study of new mechanisms in dopaminergic cell death in mouse Jonas Galper, MD, PhD Michael J Fox Foundation models for Parkinson’s disease NIH/NHLBI R01 HL114794-01, Basic Define the role of the retinoblastoma pathway in Gordon Huggins, MD Mechanisms of Human aortic valve disease Calcific Aortic Valve Disease (PI) NIH R01 HL119290, “Smooth Muscle Mineralocorticoid Receptors in Vascular Total Costs: $2,394,163; Aging and Hypertension”. 2014-2018. American Heart Iris Jaffe, MD, PhD (PI) Association Established Investigator Award, “Extra-Renal Mineralocorticoid Receptors in Hypertension and EIA18290005, Total Atherosclerosis”. Costs: $400,000; 2014-2018. American Heart Association, Predoctoral Kathleen Barrett Meuler (PI), “Role of Endothelial Mineralocorticoid Receptors in Early Morning Award, 13PRE16920014, Hypertension”. Iris Jaffe, MD, PhD (Mentor) Total Costs $44,000; 2013-2015.

27 Reasearch Grant Support (continued)

Recipient Funding Source Purpose of award American Heart Association, Postdoctoral Jennifer Dupont (PI), “SMC-Mineralocorticoid Receptor Regulation of Aging-Associated Award, 15POST2130000, Hypertension: Role of Vascular LTCC and Ang II Signaling”. Iris Jaffe, MD, PhD (Mentor) Total Costs $87,600, 2015-2017. Novartis Pharmaceuticals

» Co, Preclinical Research »

DIVISION OF DIVISION “Acute and Sustained Cardiac and Vascular Effects of Serelaxin in Study RLX030AUSNC14T the Angiotensin II/L-NAME Heart Failure Model”. Total Cost: $192,020; Iris Jaffe, MD, PhD 2014-2015. NIH R01 HL095590, Total CARDIOLOGY Costs: $2,062,500; 2009 “The Role of Vascular MR-Regulated Genes in Vascular Function – 2014, No cost extension and Disease”. to June 30, 2015.

Abiomed Translational research

Navin Kapur, MD Tracon Pharma Translational research Maquet Translational research Cardiac Assist Translational research “The Role of PKG-1a in cGMP Signaling Mechanisms through the Merck Evaluation pf the Effects of cGMP Modulations in Normal and Richard Karas, MD, PhD / Disease Studies in the PKG1-LZM Mouse” Robert Blanton, MD “TAC LKR140269”: Testing the ability of experimental therapeutics Merck on heart remodeling The Effect of Prasugrel as Compared to Clopidogrel on Platelet Function Immediately Following the Termination of Intravenous Carey Kimmeltstiel, MD Eli Lilly/Daiichi Sankyo Bivalirudin in Patients Undergoing Percutaneous Coronary and Structural Cardiac Intervention A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Long-term Treatment with BELVIQ (lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Eisai Pharmaceuticals Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects with Cardiovascular Disease or Multiple Jeffrey Kuvin, MD Cardiovascular Risk Factors A Randomized, Double-Blind, Placebo-Controlled, Parallel- Group Study to Evaluate the Effect of SAR236553/REGN727 on Sanofi Pharmaceuticals the Occurrence of Cardiovascular Events in Patients who have Recently Experienced an Acute Coronary Syndrome (Odyssey). James Udelson, MD NHLBI Subcontract for SPECT image core lab for the PROMISE trial

Honors and Awards

Robert Blanton, MD »» Awarded Citation for “top 10% of abstracts,” American Heart Association Basic Cardiovascular Sciences

David DeNofrio, MD »» Co-Chair, Program Committee, Heart Failure Society of America »» UNOS Region 1 Review Committee for Heart Transplantation »» Boston Magazine’s Top Doctors List for Cardiology

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 N. A. Mark Estes, MD »» Editorial Boards, Circulation, Arrhythmias and Electrophysiology, Circulation, Journal of the American College of Cardiology, American Journal of Cardiology, US Cardiology, Journal of Cardiovascular Electrophysiology, Pacing and Clinical Electrophysiology, Hellenic Journal of Cardiology, Associate Editor, Journal of Interventional Cardiac Electrophysiology, Heart Rhythm »» Section Editor, Controversies in Cardiology, Circulation »» Editor in Chief, Cardiology Up to Date »» Co-Chair ACC/AHA Task Force on Performance Measures for Atrial Fibrillation »» Named in “Best Doctors in America”, Best Doctors in Boston »

»» ACC Quality in Technology Committee » DIVISION OF DIVISION »» HRS Performance Measures Task Force »» Paul Dudley White Award- AHA »» Distinguished Leadership Award- AHA CARDIOLOGY »» President’s Award- Heart Rhythm Society

Jonas Galper, MD, PhD »» Editorial Board Journal of Biological Chemistry »» Patient Care assessment committee, Tufts Medical Center »» MCRI training grant committee, vice chair »» ESTA Study Section NIH Ad hoc Reviewer

Munther Homoud, MD »» Recognized for Excellence in Teaching, Tufts University School of Medicine »» Division of Cardiology Fellowship Teaching Award »» Boston Magazine “Top Doctors” List »» Reviewer, American Journal of Cardiology, Heart Rhythm

Gordon Huggins, MD »» Chair, Scientific Review Committee for non-cancer studies at Tufts Medical Center »» Vice Chair, Institutional Review Board Tufts Medical Center »» Co-Director, Tufts University School of Medicine MD PhD Program

Iris Zamir Jaffe, MD, PhD »» Editorial Board: Endocrinology »» American Society of Hypertension (ASH) 2013 Young Scholar Award »» American Society of Clinical Investigation Elected Member (2013) »» American Heart Association Established Investigator Award (2014) »» AHA High Blood Pressure Research Council Mid-Career Award for Research Excellence (2014)

Navin Kapur, MD »» Vice-Chair: American Heart Association, Clinical Cardiology – Interventional Committee 2013-2015 »» Section Leader: AHA Interventional Cardiology Track – Heart Failure/Hemodynamics 2011-2014 »» Co-Chair: SCAI Interventional Heart Failure Committee 2013-2015 »» Elected Member: AHA Basic Cardiovascular Sciences Section – 2014-2015 »» Co-Chair ACC/SCAI/HFSA Consensus Statement Committee: Invasive Hemodynamics 2013/2014 »» Chair: Cardiogenic Shock Symposium: Heart Failure Society of America 2013-2014 »» Chair: Mechanical Support for Cardiogenic Shock: C3 Symposium 2013-2014

29 »» Elected Member: Scientific Affairs Committee of Tufts University School of Medicine »» Elected Member: Cardiovascular Research Foundation: Scientific Advisory Board on High Risk Cardiac Interventions 2013-2015 »» Editorial Board Member: Catheterization and Cardiovascular Interventions »» Editorial Board Member: Journal of Invasive Cardiology »» Editorial Board Member: Heart : Journal of the British Cardiovascular Society

Richard Karas, MD, PhD »» Chief Scientific Officer, Tufts Medical Center »

» »» Vice Chairman for Scientific Affairs, Department of Medicine DIVISION OF DIVISION »» Executive Director, Molecular Cardiology Research Institute »» Chairman, Evaluation and Policy Subcommittee, National Research Committee, American Heart Association »» AHA National Research Committee CARDIOLOGY

Michael Kiernan, MD »» American Heart Association, Council on Clinical Cardiology Committee on Heart Failure / Transplantation »» American Heart Association, Council on Clinical Cardiology Committee: Fellow in Training / Early Career Subcommittee »» AHA Writing Group: Biomarkers for the prevention, assessment, and management of heart failure: a consensus statement from the American Heart Association. »» AHA Writing Group: Cardiovascular function and treatment in ß-thalassemia major: a consensus statement from the American Heart Association. »» AHA Writing Group: Recommendations for the Use of Mechanical Circulatory Support »» AHA Writing Group: Antibody Mediated Rejection in Cardiac Transplantation »» Co-Chair: NIH Heart Failure Network Cardiorenal Syndrome Working Group

Carey Kimmelstiel, MD »» Editorial Board: Journal of Thrombosis and Thrombolysis Editorial Board - Catheterization and Cardiovascular Interventions »» Abstract Grader: American College of Cardiology; American Heart Association; Transcatheter Therapeutics »» Manuscript reviewer: Cardiology, Journal of Investigative Medicine, Journal of Thrombosis and Thrombolysis, Journal of Interventional Cardiology, Circulation, American Heart Journal, Catheterization and Cardiovascular Interventions, Journal of the American College of Cardiology, New England Journal of Medicine »» Grant reviewer/grader – SCAI FIT (Fellowship In Training) Grant »» Named in “Best Doctors in America” and Best of Boston Magazine »» National Co-PI of ION Drug-Eluting Stent Trial »» SCAI Fellow in Training Grant »» Abbott Fellow in Training Grant

Marvin Konstam, MD »» Named in “Best Doctors in America” 2005-2013 »» Member, Association of University Cardiologists »» Past President, Association of Professors of Cardiology »» Past President, Heart Failure Society of America »» Clinical Practice Guideline Committees, Heart Failure Society of America, Agency for Health Care Policy and Research, and AHA/ACC »» Former Senior Advisor in Cardiovascular Diseases, National Heart Lung and Blood Institute »» Member, CMS/The Joint Commission/ACC/AHA AMI/Heart Failure Technical Expert Panel »» Member, ACGME Advisory Committee for Advanced Heart Failure and Transplant Cardiology »» Chair, American College of Cardiology, Council on Academic Cardiology

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» Co-Chair National Heart Lung and Blood Institute, Workshop on Heart Failure Prevention »» Distinguished Faculty Award, Tufts University School of Medicine

Jeffrey Kuvin, MD »» Boston Magazine’s “Top Doctors” (Cardiology) »» American College of Cardiology, COCATS Task Force »» American College of Cardiology, Lifelong Learning Oversight Committee »» American College of Cardiology, Competency Development Work Group »

»» American College of Cardiology, Faculty Development Work Group » DIVISION OF DIVISION »» American College of Cardiology, Curriculum Development Work Group »» American College of Cardiology, Co-Chair, Annual Scientific Session Program »» American Heart Association, Vice-Chair, Laennec and Post-Graduate Education Committee CARDIOLOGY »» American Heart Association, Professional Education Committee »» American Heart Association, Paul Dudley White Award Committee »» NRMP Specialties Matching Service, Liaison for Cardiovascular Disease »» ACGME Standing Panel for Accreditation Appeals »» Nominating Committee, Tufts Medical Center Physicians’ Organization Board of Trustees

Mark Link, MD »» Chair: AHA Writing Group-Adult Cardiac Life Support Guidelines, 2015 »» AHA Emergency Care Committee, 2013-2015 »» Heart Rhythm Society: Education Committee Member. 2014-5 »» Chair: Heart Rhythms Society: CME Compliance Committee. 2014-5 »» AHA Writing Group 2012-2015: Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities »» Task Force 2: Hypertrophic Cardiomyopathy, Other Cardiomyopathies, and Myocarditis; Task Force 8: Arrhythmias and Conduction Defects; Chair: Task Force 11: Emergency Action Plans, Resuscitation, CPR, and AEDs; Chair: Task Force 12: Commotio Cordis; Task Force 15: Classification of Sport: Dynamic, Static and Impact »» Listed as one of Boston Magazines “Best Doctors”-2010-2014 »» Associate Editor-Journal Watch Cardiology »» Editorial Board-EP Lab Digest »» Editorial Board-Heart Rhythm »» Editorial Board-Journal of Innovations in Cardiac Rhythm Management »» Clinical Events Committee for multi-center trials

Martin Maron, MD »» Editorial Board: American Journal of Cardiology »» Editorial Board: Journal of the American College of Cardiology

Natesa Pandian, MD »» ACC Writing Group on Rheumatic Fever »» ACC Scientific Sessions, Program Committee, 2014, 2015 »» Invited speaker, Cardiology Grand Rounds, Cedars Sinai Hospital, Los Angeles, 2014 »» Invited Faculty, ACC Annual Scientific Sessions, 2014 »» Invited Faculty at ASE Board Review Courses, 2014 »» Invited Faculty at the ASE Annual Scientific Sessions, 2014

31 »» Invited Faculty at the annual Japanese Echocardiography Society Conference 2014 »» Invited Faculty at the European Society of Cardiology Annual Scientific Sessions, 2014 »» Invited Faculty at the Conference on Aortic Stenosis, Ascoli, 2014 »» Invited Faculty at the Italian Society of Echocardiography Annual Conference, 2014 »» Invited Faculty at the Indian Academy of Echocardiography Annual Conference, 2014 »» Invited Faculty at the Cardiology Rounds 2014, Hoag Hospital »» Invited Faculty at the Cardiological Society of India Annual Scientific Sessions, 2014 »

» Ayan Patel, MD DIVISION OF DIVISION »» Associate Editor: Circulation Heart Failure »» FASE, American Society of Echocardiography

CARDIOLOGY Deeb Salem, MD »» Chairman, Mass Medical Society’s Committee on Sponsored Programs »» Chairman, Tufts University School of Medicine Continuing Education Committee »» Massachusetts Hospital Association, Board of Trustees

James Udelson, MD »» Distinguished Faculty Award, Tufts University School of Medicine 2012 »» Editor-in-Chief, Circulation: Heart Failure »» Associate Editor, Circulation »» Editorial Board – JACC, JACC Imaging, Journal of Nuclear Cardiology, Current Cardiovascular Imaging Reports, Heart Failure Reviews, US Cardiology »» U.S. Food and Drug Administration, Special Government Employee »» Member, Association of University Cardiologists »» Member, Association of Professors of Cardiology »» Best Faculty Teacher Award from Tufts Medical Center Internal Medicine Residents »» Ad-hoc Member, Cardiovascular and Renal Drugs Advisory Panel, Center for Drug Evaluation and Research, United States Food and Drug Administration »» Co-Chair, ACC/ACR Writing Committee for Appropriate Use Criteria to Assess Imaging Modalities to Evaluate Chest Pain in the Emergency Department »» Heart Failure Society of America, Executive Council »» Best Doctors in Boston, Boston Magazine »» Associate Editor, Practice Update in Cardiology »» Co-Chair, ASNC/SNMMI Think Tank on Cardiovascular Molecular Imaging

Amanda Vest, MD »» Heart Failure Society of America (HFSA) Guideline Committee

Jonathan Weinstock, MD »» US News and World Report, Top Doctor »» Abstract Reviewer, American Heart Association Scientific Sessions »» Manuscript Reviewer, Heart Rhythm, Journal of Interventional Cardiac Electrophysiology

Andrew Weintraub, MD »» Listed, Best Doctor in America »» Listed, Best Doctors in Boston »» Manuscript Reviewer, Circulation Heart Failure, Circulation Interventional Cardiology

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 DIVISION OF CLINICAL CARE RESEARCH

The Division of Clinical Care Research has no clinical programs of its own. Physician-researcher Division » » members have appointments in Medicine, Pediatrics RESEARCH CARE CLINICAL OF DIVISION and Psychiatry where they are active participants in clinical activities. The following physicians have primary appointments in clinical divisions of the Department of Medicine:

»» Harry Selker, MD Harry Selker, MD Internal Medicine and Adult Primary Care Pratt Diagnostic Center »» Karen Freund, MD Internal Medicine and Adult Primary Care »» David Kent, MD Internal Medicine and Adult Primary Care »» Susan Parsons, MD Hematology-Oncology

For further details regarding their clinical, teaching and research responsibilities, please see the reports of those divisions and of the Institute for Clinical Research and Health Policy Studies.

33 DIVISION OF CLINICAL DECISION MAKING » » CLINICAL DECISION MAKING, INFORMATICS AND TELEMEDICINE AND INFORMATICS MAKING, DECISION CLINICAL OF DIVISION “Tufts Medical Center has the only unit in the world that ties the principles of logical decision analysis to the care of individual patients. It is concerned with identifying strategies of patient care that minimize unnecessary tests and procedures, increase patients’ participation in decisions affecting their care, and decrease the cost of medical care.” —The Best Hospitals in America: The Authoritative Reference Guide for Patients, Their Families and Medical Professionals.”

The Division of Clinical Decision Making began as collaboration between computer scientists John Wong, MD at the Massachusetts Institute of Technology and physicians at Tufts Medical Center and Tufts University School of Medicine. Under the guidance of Drs. Stephen Pauker and Jerome Kassirer, the Division was formally established in 1980 to conduct research, teach students, train physicians and provide consultations. The Clinical Consultation Service responds to requests from physicians who are uncertain as to the optimal management strategy for a patient and provides advice based on literature review and formal decision analysis explicitly weighing the risks and benefits of the alternatives.

The division has become a critical component of sophisticated medical systems and a crucial element of medical school teaching. Many would agree that there is simply too much information available now for even subspecialists to master in their own field. The student, the practitioner and the research scientist must learn how to efficiently access the huge volume of information available, how to digest it critically, and how to use the information to make clinical decisions. Highlights of 2014

»» Committee Member, Institute of Medicine, Diagnostic Error in Health Care (Dr. Wong)

»» Systematic Review Member, American Association for the Study of Liver Disease, Hepatitis B Guidelines (Dr. Wong)

»» Keynote Lecturer, Society for Medical Decision Making European Meeting, Antwerp, Belgium (Dr. Kassirer)

»» Member, Human Factors Subcommittee of the National Committee on Forensic Science (Dr. Kassirer)

»» Past President, Society for Clinical and Experimental Hypnosis (Dr. Pauker)

»» Committee Member, Institute of Medicine, End of Life (Dr. Pauker)

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibility John B Wong, MD Professor Division Chief Brian J Cohen, MD Assistant Professor Medical Director, Pratt Diagnostic Center Jerome P Kassirer, MD Distinguished Professor Senior Advisor Stephen G Pauker, MD Professor Division Chief Emeritus » »

Major Clinical Programs TELEMEDICINE AND INFORMATICS MAKING, DECISION CLINICAL OF DIVISION Clinical Decision Consultation Service The Division provides consultations to physicians who are uncertain as to the optimal management strategy for an individual patient. The service provides advice based on literature review and formal decision analysis. The process explicitly weighs the harms and benefits of the alternatives and often the preferences of the specific patient. Typical consultations involve complex clinical problems or problems that involve difficult tradeoffs: patients with combinations of conditions that make traditional strategies of care problematic, instances in which there is conflicting information, and decisions that need to reflect strongly individual patient preferences.

Clinical Hypnosis Consultation Service This service provides consultation on the application of medical hypnosis for a wide variety of conditions including undesired habits, anxiety, sleep disorders, chronic pain, and chemotherapy-related nausea.

Teaching Activities Evidence-based Medicine Tufts 1st year medical students are introduced to the general principles of evidence-based medicine (how to formulate well constructed questions and then find and evaluate information).

Clinical Decision Making In this elective course, 4th year Tufts medical students learn the rudiments of clinical decision-making, including the interpretation of clinical data and test results using Bayes’ rule, the analysis of the risks, harms and benefits of clinical decisions, the estimation and use of probabilities and of prognosis, and the evaluation of outcomes. Students also review the cognitive processes involved in clinical reasoning, exploring the steps used by expert clinicians and identifying potential pitfalls in solving clinical problems. The student participates in clinical consultations and learns how to critically evaluate the medical literature.

Medical Hypnosis Dr. Pauker provides training in medical hypnosis at Tufts Medical Center for medical students and also teaches in annual workshops given by the New England Society for Clinical Hypnosis.

Research The Division focuses its research on clinical decision analysis, cost-effectiveness and health policy analysis. The studies examine clinical and policy questions involving the information content of the medical history, physical examination and diagnostic tests, determination of the optimal diagnostic test or test sequence, selection of the best therapy, and evaluation of new medical technologies (tests, devices or drugs). It uses the tools of decision analysis, utility assessment, literature synthesis, medical informatics, Markov model development, Monte Carlo simulation, Bayesian interpretation of diagnostic tests, measurement of patient preferences, cost- effectiveness analysis, literature review, meta-analysis and discrete event simulation to assess comparative effectiveness.

Members of the Division are familiar with the use of techniques for assessing patient preferences and incorporating them into clinical decision making. Current research projects include assessments of coronary heart disease treatments, colon cancer screening, HIV and hepatitis C screening, screening for hypercholesterolemia in adolescents, epilepsy treatment, decision aids for shared decision making, anticoagulation for atrial fibrillation, cost-effectiveness of Tai Chi for osteoarthritis and methodological recommendations for performing decision analysis modeling.

35 Clinical Research Support

Recipient Funding source Purpose of award AHRQ Methods Research and Support in Decision and Simulation Modeling CMS ECHO: Increasing Capacity to Deliver Care to High Cost Medicaid Populations NIH/NCCAM Tai Chi and Physical Therapy for Knee Osteoarthritis NIH/NCCAM Mentoring and Research in Patient-Oriented Integrative Medicine NIH/NCRR Clinical and Translational Science Institute Award » » CLINICAL DECISION MAKING, INFORMATICS AND TELEMEDICINE AND INFORMATICS MAKING, DECISION CLINICAL OF DIVISION NIH/NCI A Prediction Model for Tailoring Use of Screening Colonoscopy Comparative Effectiveness of Economic Incentives for Heart Disease NIH/NIA Prevention NIH/NIA Expanding the National Health Accounts RCT of an integrated Treatment of Persons with Co-Occurring HCV NIH/NIAA John Wong, MD and Alcohol Abuse NIH/NIAAA Value of Personalized Risk Information A Randomized Trial of Continued Methadone Maintenance vs. Detoxification NIH/NIDA in Jail NIH/NIDA CARE Corrections: Technology for Jail HIV/HCV Testing, Linkage and Care Integrating Causal Inference, Evidence Synthesis, and Research PCORI Prioritization Methods Comparative Effectiveness of Adolescent Lipid Screening and PCORI Treatment Strategies A Method for Patient-Centered Enrollment in Comparative Effectiveness PCORI Trials: Mathematical Equipoise PCORI Funded Clinical Research Network Project with the Chicago Community Trust

Health Care Policy and Clinical Practice The Division has been involved with numerous consensus conferences, guideline development processes and appropriateness of care assessment for the National Institutes of Health (NIH), Office of Medical Applications Research (OMAR), Institute of Medicine (IOM), American College of Cardiology (ACC), American College of Chest Physicians (ACCP), American College of Physicians (ACP), Outcome Measures in Rheumatology (OMERACT), American Association for the Study of Liver Disease, (AASLD), Centers for Disease Control and Prevention (CDC), Medicare Evidence Development Advisory Committee (MedCAC), the CDC Working Group Evaluating Genetic and Genomic Testing (EGAPP), European League Against Rheumatism (EULAR) and the World Health Organization (WHO). The Division has also translated guidelines into quality improvement and performance measures through the AMA Physician Consortium for Performance Improvement Work Group (AASLD/AGA/AHA/ACC/AMA) on Hepatitis C, Coronary Artery Disease, Hypertension, Heart Failure, and Cardiac Imaging. In addition, the Division has been engaged in Patient Outcome Research Teams (PORTs) sponsored by the then Agency for Health Care Policy and Research (AHCPR) on Chronic Ischemic Heart Disease and Diabetes Mellitus. Lastly, the Division has developed decision aids for shared decision making through the Informed Medical Decisions Foundation and Healthwise to increase patient knowledge and help patients understand the role that their outcome preferences may play in their care decisions.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Honors and Awards

John Wong, MD, FACP »» Co-chair, American Medical Association/American Gastroenterological Association/Association for the Study of Liver Disease, Physician Consortium for Performance Improvement. Work Group on Hepatitis C »» Committee Member, Institute of Medicine (IOM), Diagnostic Error in Health Care »» Systematic Review Member, American Association for the Study of Liver Disease (AASLD), Hepatitis B Guidelines »» Discussion Leader, Patient-Centered Outcomes Research Institute, Hepatitis C Workshop (Screening and Diagnostic Tests)

»» Chair, Awards Committee, Society for Medical Decision Making » » CLINICAL DECISION MAKING, INFORMATICS AND TELEMEDICINE AND INFORMATICS MAKING, DECISION CLINICAL OF DIVISION

Jerome Kassirer, MD, MACP »» Keynote Lecturer, Society for Medical Decision Making European Meeting, Antwerp, Belgium »» Member, Human Factors Subcommittee of the National Committee on Forensic Science »» Senior Editorial Advisor for Circulation: Cardiovascular Quality and Outcomes »» Visiting Professor at Stanford University; collaborating with Arnold Milstein's group on Care Redesign »» Consultant, Center for Outcomes Research and Evaluation, Yale University

Stephen Pauker, MD, MACP, FACC, FACMI, ABMH »» Past President, Society for Clinical and Experimental Hypnosis »» Certified Consultant in Hypnosis, Active Commitment to Excellence (SCEH-ACE), Society for Clinical and Experimental Hypnosis »» Re-Certification Approved Consultant, American Society of Clinical Hypnosis »» Committee Member, Institute of Medicine, End of Life »» Member, Institute of Medicine »» Member, CDC Working Group for Evaluation of Genomic Applications for Populations and Prevention (EGAPP) »» Member, American Board of Medical Hypnosis Examining Body

Brian Cohen, MD »» Castle Connolly Top Doctor

37 DIVISION OF CLINICAL NUTRITION

Nutrition plays a key role in disease risk as well as in healing. There is increasing evidence for novel roles of nutrients in inflammation, » »

CLINICAL NUTRITION CLINICAL OF DIVISION immune function, carcinogenesis, and cognitive decline. Members of the Division of Clinical Nutrition are nationally known nutrition researchers and clinicians who provide an array of consultative nutrition services to acutely and chronically ill patients.

Tufts University is a national and international leader in nutrition care, education and research. Tufts Medical Center and Tufts University School of Medicine have long had a strong focus on the clinical, training, and research aspects of human nutrition. The campus features a Edward Saltzman, MD remarkable array of resources, including the Division of Clinical Nutrition at Tufts Medical Center, the Frances Stern Nutrition Center (FSNC), the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA), and the Friedman School of Nutrition and Science Policy Highlights of 2014

»» Dr. Edward Saltzman appointed Academic Dean for Education, Friedman School of Nutrition Science and Policy.

»» Dr. Joel Mason selected by Boston Magazine as a Best of Boston gastroenterologist.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibility » »

Edward Saltzman, MD Associate Professor Chief NUTRITION CLINICAL OF DIVISION Johanna Dwyer, PhD Professor Director, Frances Stern Nutrition Center Joel Mason, MD Professor Director, GI Nutrition Clinic Irwin Rosenberg, MD University Professor

Major Clinical Programs Adult Nutrition Support Service The adult Nutrition Support Service (NSS), under the direction of Dr. Saltzman, provides expert nutritional consultations for inpatients who require enteral or parenteral nutrition support and for patients who require continued nutrition support after discharge. The attending staff also provides interpretation of indirect calorimetry (metabolic rate) studies.

GI Nutrition Clinic Under the supervision of Dr. Mason, a nationally recognized expert in nutritional management of malabsorptive disorders, this clinic provides care for patients with complex nutritional disorders.

Tufts Medical Center Committee on Nutrition To insure that nutrition practices at Tufts Medical Center are uniform and consistent with current best practices, the Nutrition Committee monitors provision of nutrition care throughout the medical center and contributes to development of policies and procedures.

Teaching Activities Division members participate extensively in the education of students at Tufts University School of Medicine. Dr. Saltzman directs the second-year course in Nutrition and Medicine. Residents and Fellows in multiple medical subspecialties rotate through the inpatient Nutrition Support Service and GI Nutrition clinic. Dietetic interns who are training to become Registered Dieticians in the Frances Stern Nutrition Center have required rotations on the inpatient Nutrition Support Service.

Members of the division are also active in the Friedman School of Nutrition and Science Policy, where Dr. Saltzman is Academic Dean for Education. Division member provide classroom teaching and serve as mentors for doctoral students.

Research Activity Several members conduct research at the HNRCA, one of six USDA supported national nutrition research centers. Dr. Mason directs the Vitamins and Carcinogenesis Laboratory and Dr. Rosenberg directs the Neuroscience and Aging Laboratory. Dr. Saltzman is Medical Director of the Metabolic Research Unit, the HNRCA's inpatient unit, and is a member of the Energy Metabolism laboratory at the HNRC. Dr. Dwyer serves a Senior Nutrition Scientist in the Office of Dietary Supplements, National Institutes of Health.

39 Honors and Awards

Johanna Dwyer, PhD »» Trailblazer Award sponsored by the Institute of Food Technologies and the Academy of Nutrition and Dietetics »» Editor, Nutrition Today

Joel Mason, MD »» Received the E.V. McCullom Award from the American Society of Nutrition »» Co-chair of the national annual conference, Advances and Controversies in Clinical Nutrition » »

CLINICAL NUTRITION CLINICAL OF DIVISION »» Representative for nutrition and cancer, Research Executive Committee, Tufts Cancer Center

Irwin Rosenberg »» Editor in Chief, Food and Nutrition Bulletin

Edward Saltzman, MD »» Member, Board of Directors, American Society for Nutrition »» Member, Editorial Board, American Journal of Clinical Nutrition

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 DIVISION OF ENDOCRINOLOGY, DIABETES AND METABOLISM » » The Division of Endocrinology at Tufts Medical Center METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION offers clinical services ranging from comprehensive diabetes management to subspecialty outpatient clinics devoted to pituitary, bone, thyroid, and adrenal disorders and endocrine neoplasia. In addition to a wide variety of teaching activities for medical students, residents and endocrinology fellows, the Division offers selective courses in clinical endocrinology and endocrine research for medical students

Ronald Lechan, MD in order to foster interest in this subspecialty.

The Division has a distinguished history dating to the 1940’s when Dr. Edwin B. Astwood became its first Chief. During his tenure, a number of advances were made including the introduction of drugs for the treatment of hyperthyroidism, the use of thyroid hormone therapy for the treatment of thyroid nodules, the isolation and preparation of ACTH for clinical use and the purification of human growth hormone, allowing the first treatment for pituitary dwarfism.

In 1972, Dr. Seymour Reichlin, a world-renowned leader in the field of neuroendocrinology and disorders of the thyroid gland, became Chief of the Division. Outstanding achievements made during his tenure included the development of the first radioimmunoassay for thyrotropin-releasing hormone (TRH), identification of the origin of the hypothalamic tuberoinfundibular system, elucidation of the somatostatin and TRH genes and studies on the mechanisms of somatostatin, TRH and prolactin secretion, demonstration of the role of the immune system in neuroendocrine regulation, studies on the evaluation and treatment of hyperprolactinemia, and the diagnosis and treatment of patients with MEN II syndrome.

With the formation of the Human Nutrition Research Center on Aging, the Endocrinology Division gained prominence for its studies of disorders of lipids, calcium metabolism and obesity. In 1990, Dr. A.E. Boyd, III became Chief and brought expertise in diabetes mellitus and molecular biology. The Division grew rapidly when Dr. Boyd merged the Division of Molecular Medicine with the Division of Endocrinology. After Dr. Boyd’s untimely death in 1995, Dr. Ronald Lechan assumed leadership of the Division. During this time, the Division has continued its research interests in bone metabolism, diabetes, neuroendocrinology, obesity and adipocyte function, and has substantially grown its clinical program to involve offsite programs in Quincy, Norfolk and the Merrimack Valley. Division members have received numerous grants, awards, prestigious lectureships and committee memberships.

Highlights of 2014

»» Grant renewal from the Gerald J. and Dorothy R. Friedman Foundation for Medical Research to support research and fellowship training in Endocrinology, Diabetes and Metabolism

»» Discovery of a novel role for acyl CoA synthetase 5 in the development of obesity

»» Publication of 34 peer-reviewed papers, book chapters and reviews

»» Implementation of the Norfolk Specialty Center to provide care to patients with a variety of endocrine disorders in the Norfolk and surrounding communities

41 Faculty

Name Academic Rank Title and Special Responsibility Chief of Division Director, Fellowship Program Ronald M. Lechan, MD, PhD Professor Director, Neuroendocrine Clinic Co-director, Neuroendocrine & Pituitary Program Lisa Ceglia, MD Assistant Professor Director, Bone Clinic

» Michael Dansinger, MD Assistant Professor Director, Diabetes Reversal Program » ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION Bess Dawson-Hughes, MD Professor Director, Bone-Metabolism Laboratory, HNRC Csaba Fekete, MD, PhD Adjunct Professor Professor of Neurobiology, Hungarian Academy of Science Dr. Robert C and Veronica Atkins Professor in Metabolism and Nutrition Andrew S. Greenberg, MD Professor Director, Obesity and Metabolism Laboratory at Jean Mayer USDA Human Nutrition Research Center at Tufts University Director, Thyroid Clinic and of Ultrasound and Jacqueline Kung, MD Assistant Professor Fine Needle Aspiration Thyroid Clinic Director, Diabetes Clinic Anastassios G. Pittas, MD, MS Professor Associate Director, Fellowship Program General Endocrinologist Aruna Saraswat, MD Professor Emeritus Consultant for Tufts Medical Center Primary Care-Quincy and Norfolk Specialty Care Center Seymour Reichlin, MD Professor Emeritus Director, Diabetes Clinic Director, Internal Medicine Residency Endocrine Rotation Richard Siegel, MD Associate Professor Director, 4th Year Medical Student Endocrine Elective Co-Director, From Health To Disease III: 2nd Year Medical Student Endocrine Course Jeffrey Tatro, PhD Associate Professor Researcher Roberto Toni, MD, PhD Adjunct Professor Professor of Human Anatomy, University of Parma School of Medicine Nurse Practitioner Mary Wenners, NP and Certified Diabetes Director of the Friedman Foundation Diabetes Education Program Educator Certified Diabetes Paula Dabenigno, RN Diabetes Educator Educator

Major Clinical Programs The Division of Endocrinology offers complete diagnostic and therapeutic services for common and complex endocrine disorders. A variety of subspecialty outpatient clinics provide expert and investigational treatments, namely:

»» Bone Disease (Dr. Lisa Ceglia) »» Thyroid Disease and Thyroid Cancer (Dr. Jacqueline Kung) »» Diabetes and Metabolism (Drs. Richard Siegel, Anastassios Pittas, Lisa Ceglia) »» Obesity (in collaboration with the Obesity Consultation Center, Dr. Richard Siegel) »» Neuroendocrinology and Endocrine Neoplasia (Dr. Ronald Lechan) »» Diabetes Reversal Program (Dr. Michael Dansinger) »» General Endocrinology (Drs. Lisa Ceglia, Jacqueline Kung, Ronald Lechan, Aruna Saraswat, Richard Siegel)

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 The inpatient consultation team offers diabetes management services for hospitalized patients. Under the direction of Dr. Richard Siegel, protocols for insulin management in the intensive care units and insulin order forms have been developed and implemented on medical and surgical floors to improve diabetes management in the hospital. Dr. Siegel has begun a novel telemedicine consult program with Patient Advocates in Maine, focused on the care of patients with diabetes mellitus. Under the direction of Dr. Michael Dansinger, the Diabetes Reversal Program at Tufts Medical Center was introduced in which diet and exercise is used to achieve remission in approximately 36% of patients with type 2 diabetes. Mary Wenners, NP oversees an insulin pump program as well as an Asian Outreach Screening Program to identify patients in the local community with diabetes mellitus. Under the direction of Dr. Jacqueline Kung, the thyroid cancer program has been expanded to include mutational testing and gene expression classifier testing on fine needle biopsy aspirates of thyroid »

nodules. » ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION In collaboration with the De partments of Neurosurgery, Radiology and Ophthalmology, a multidisciplinary neuroendocrine pituitary program was developed under the direction of Drs. Ronald Lechan and Carl Heilman to facilitate the evaluation and care of patients with hypothalamic and pituitary disorders. The Division is also working collaboratively with the Division of Internal Medicine and Adult Primary Care to improve the care of patients with type 1 and type 2 diabetes mellitus, and with the Department of Orthopedics to improve bone health for patients with recent bone fractures, and has established satellite clinics in Quincy, Norfolk and the Merrimack Valley to assist NEQCA physicians with the care of their patients with diabetes and other endocrine disorders. Our newest faculty member, Dr. Aruna Saraswat, has been particularly instrumental in overseeing the latter endeavor.

Teaching Activities The Division offers fellowship training in Endocrinology, Diabetes and Metabolism, accepting two new Fellows each year into a 2 year clinical or 3 year clinical/research program. One new Fellow each year is supported by a grant from The Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research. Included in the teaching activities are formal lectures on topics in endocrinology, instruction in thyroid ultrasound and fine needle aspiration biopsy of thyroid nodules, interpretation of bone densitometry studies, and interpretation of continuous glucose monitoring data.

The Division is also active in teaching house staff and medical students. Among the offerings are the following:

»» Selective courses in clinical endocrinology and endocrine research for medical students, supervised by Drs. Richard Siegel and Ronald Lechan »» Formal instruction in the endocrine pathophysiology course to second year medical students in the From Health to Disease III: Endocrine Course, co-directed by Dr. Richard Siegel »» Lectures at Noon Conference and participation in Morning Report for Internal Medicine Residents »» A series of lectures for first year Fellows in the endocrinology training program »» Electives in the endocrinology clinics and on the endocrinology consultation services for both medical students and Internal Medicine Residents.

Faculty members have also been mentors, served on PhD and MS Thesis Committees, and participated in teaching in the Medical School, Sackler School of Graduate Biomedical Sciences, USDA Human Nutrition Center, Dental School, Friedman School of Nutrition and Health Policy, University of Parma and Hungarian Institute of Science. Division members were also involved in teaching trainees at the American Thyroid Association Annual meeting, in evidence- based didactic training of dietitians at Boston Heart Diagnostics, in one-on-one mentoring of students and Residents who rotate through the Diabetes Reversal Program in the Endocrinology Clinic, and in teaching engagements at the University of Parma and the Janos Szentagothai Neuroscience School of the Semmelweis University. In addition, a series of multimedia web lectures was developed on human embryology and the anatomy of the head and neck, (www. anfamedmuseo.unipr.it). Dr. Andrew Greenberg is the PI on a NIH T32 award that provides research training in nutrition, obesity and metabolic diseases to predoctoral students at the School of Nutrition at Tufts University.

43 Research Activities The commitment to research by the faculty continues to be a major focus of the Division. Success in this endeavor is indicated by the publication record of the faculty that includes 34 peer reviewed papers, book chapters and reviews, and a major, $40 million award to Dr. Taso Pittas to study the effects of vitamin D on diabetes mellitus.

Support for faculty research is derived from 4 R01, 2 U01, 1 P30, 1 T32 and a contract from the NIH, 2 grants from the USDA, 1 grant from the ADA, 1 grant from the Department of Defense, 2 grants from the Gerald J. and Dorothy R. Friedman Foundation for Medical Research, grants from the Italian Ministry of Research, University of Parma, Hungarian Academy of Science and European Union, as well as 9 other grants from foundations and industry. Six new »

» grants were awarded to Division members this year. ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION Highlights of recent research accomplishments include:

»» Discovery of a novel role of acyl CoA synthetase 5 in the development of obesity and regulation of cholesterol »» Comparison of the effectiveness of Atkins, Zone, Weight Watchers and Ornish diets for increasing large HDL levels in plasma »» Demonstration that vitamin D supplementation has beneficial effects on muscle fiber size and increases intramyonuclear vitamin D receptor (VDR) expression in older women with low vitamin D status and moderate risk of disability »» Demonstration that serum sclerostin levels are not associated with baseline or change in glucose or insulin levels in healthy participants of the STOP-IT trial »» Demonstration of a strong, inverse relationship between body weight, total adiposity and its compartments and 25OH vitamin D concentration in a multi-racial cohort of adults with pre-diabetes »» Demonstration that weight and BMI are associated with 25OH vitamin D level, in part by way of visceral body fat »» Evidence that the absorption of vitamin D is 30% higher when the meal contains fat than when it contains no fat. »» Demonstration that 43.4 million older adults in the US 50 years and older have low bone mass in the National Health and Nutrition Examination Survey and are largely non-Hispanic white women »» Development of a transgenic mouse model to detect tissue/organ-specific changes in thyroid hormone action (patent claim #P1400563) »» Mapping of the connections of the parabrachial and central nucleus of the amygdala with other feeding-activated neuronal groups in the brain »» Evidence to suggest replacement with a combination of L-T3 and L-T4 is required to normalize thyroid hormone-dependent markers in thyroidectomized animals and that when replaced with only L-T4 to normalize TSH, the brain, liver and skeletal muscle exhibits indications of hypothyroidism due to increased ubiquitination of type 2 deiodinase. »» Demonstration of the potential importance of the parasubthalamic nucleus in appetite regulation »» Demonstration that inflammation induces the expression of type 2 deiodinase in leptomeninges, choroid plexus and blood vessels in the brain »» Demonstration that the thyroid hormone transporters, OATP1 and MCT8, are downregulated by endotoxin at the blood-brain-barrier indicating reduced thyroid hormone uptake into brain parenchyml tissue during inflammation »» Differentiation of stem cells into mature thyrocytes »» Characterization of subgroups of adult, rat, mesenchymal stromal cells obtained from the bone marrow for ex situ reconstruction of bioartificial bone »» Demonstration that the cryptic fragment 53-74 of rat preproTRH stimulates replication of GH4C1 cells

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Clinical Research

Recipient Funding source Purpose of award Regeneron Pharmaceuticals, Multicenter study of effects of REGN1003 on body composition, muscle Inc* (Co-Investigator) strength and stair climb power Regeneron Pharmaceuticals, Inc.* Safety and efficacy of REGN1033 in patients with sarcopenia Lisa Ceglia, MD (Co-Investigator) Effects of 25(OH)D supplementation on muscle fiber size, vitamin D receptor

DSM Nutritional Products »

concentration and satellite cell activation in younger postmenopausal women » (PI) METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION with osteopenia.

Effectiveness of lifestyle program for former NFL players at risk for heart Boston Heart Diagnostics disease Heart Michael Dansinger, MD Boston Heart Diagnostics Effectiveness of lifestyle program for firefighters and police officers at risk for (PI) heart disease

NIH (PI) Musculoskeletal benefits of bicarbonate in older adults

Define the effects of vitamin D and calcium supplementation on glucose NIH (Co-Investigator) metabolism (with Dr. Pittas) USDA (PI)* Studies of nutrition and the aging skeleton Bess Dawson-Hughes, MD Impact of supplemental vitamin D on serum 25OHD levels and short term Pfizer (PI)* indicators of physical function Multi-center clinical trial to evaluate the safety of oral daily vitamin D NIH* (Co-Investigator) supplementation and its effect on the time of onset of clinical diabetes mellitus (with Dr. Pittas) Gerald J. and Dorothy R. Friedman Foundation for Clinical and research training in Endocrinology, Diabetes and Metabolism Medical Research* (PI) Study of pathophysiology and molecular biology of pheochromocytoma and Ronald Lechan, MD, PhD NIH, TCGA Trial* (PI) paraganglioma Tercica (PI) SODA study, Observational study of patients with acromegaly treated with somatuline Novartis* (PI) ACCESS study, Observational study of Pasireotide LAR in acromegaly CAMELLIA-TIMI study, Effect of lorcaserin on major cardiovascular events and Eisai *(Co-Investigator) conversion to type 2 DM ACCESS study, Observational study of Pasireotide LAR in acromegaly (with Dr. Richard Siegel, MD Novartis* (Co-Investigator) Lechan) SODA study, Observational study of patients with acromegaly treated with Tercica (Co-Investigator) somatuline (with Dr. Lechan) American Diabetes D2d Co-Support Award Association* (PI) U01 implementation grant: Multi-center randomized trial of vitamin D NIDDK (PI) supplementation for prevention of type 2 diabetes Anastassios Pittas, MD NIDDK (PI) Role of vitamin D in established type 2 diabetes

Department of Defense Develop more effective approaches to sustain weight loss (Co-Investigator)

* New Award in 2014

45 Basic Research

Recipient Funding source Purpose of award Study the effect of aging and high fat diet on parameters of the European Union FP7 hypothalamic-pituitary-thyroid axis Csaba Fekete, MD Hungarian Academy of Analysis of the transcriptome of hypothalamic paraventricular neurons in Sciences (PI) fasting animals that have been refed NIH (PI) Age Dependent Role of Bisphenol A in Nonalcoholic Fatty Liver Disease

» Regulation of Adipocyte and Adipose Tissue Metabolism in Obesity-

» USDA* (PI) ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION Related Inflammation and Metabolic Disorders NIH, NIDDK (PI) Research Training Program in Nutrition and Chronic Disease Andrew Greenberg, MD NIH (Co-director) Adipose Biology and Nutrient Metabolism Core NIH* (PI) Role of ACSL5 in Liver and Intestinal Triacyglycerol Metabolism NIEHS (Co-PI) Age Dependent Role of Bisphenol A in Obesity and Insulin Resistance Tufts CTSI (Co-PI) The Role of CDK6 in Adipogenesis, Obesity and Diabetes Gerald J. and Dorothy R. Ronald M. Lechan, MD, Friedman Foundation for Characterization of POMC Neurons in the Hypothalamic Arcuate Nucleus PhD Medical Research* (PI) Jeffrey Tatro, PhD NIH, Collaborator (Beasley, PI) Atherogenic role of T cell modulation by intestinal bacteria Museum of the Department of Creation of a web archive showing artistic portrayal of endocrine diseases Biomedicine, Biotechnologies in paintings and bas-reliefs throughout the world linking morphology and and Translational Sciences endocrinology Italian Ministry of Culture, Art Development of restoration procedures for 17th-19th century anatomical Roberto Toni, MD and Music specimens Italian Ministry of Research and Development of biotechnology and bioengineering strategies to develop University (MIUR) (PI) ex situ bioartificial organs University of Parma School of Molecular mechanisms regulating growth and differentiation of Medicine neuroendocrine cells

* New Award in 2014

Honors and Awards

Dr. Lisa Ceglia »» PhD Thesis Committee, Friedman School of Nutrition and Health Policy »» MS Thesis Committee, Sackler School of Graduate Biomedical Sciences Speaker, Friedman Symposium, Annual Scientific Meeting of ADA, San Francisco, CA »» Grand Rounds Speaker, Lowell General, Hospital »» Grand Rounds Speaker, Carney Hospital »» Grand Rounds Speaker, Winthrop Hospital »» Grand Rounds Speaker, Brockton Hospital »» Scientific Advisor, Amgen Bone Health Team

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Dr. Michael Dansinger »» Keynote Speaker, Pri-Med Primary Care Conference, Miami, Los Angeles, Houston, Boston and Baltimore »» Speaker, Boston Heart Diagnostics Customer Conference, Boston, MA and Charleston, SC »» NECQA/Tufts Medical Center Diabetes Advisory Committee

Dr. Bess Dawson-Hughes »» Editorial Board, Bone »» Editorial Board, Osteoporosis International »

»» Editorial Board, Calcified Tissue International » ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION »» Chapter Writer, Up-to-Date »» NOF Lawrence G. Raisz Memorial Lecture Award »» Thomson Reuters Highly cited scientist »» Scientific Advisor for BIRWCH grant at UC Davis »» General Secretariat (VP) of the International Osteoporosis Foundation »» Founding Director of the Center for the Advancement of Science in Space »» Grant Reviewer, NIAMS and NIA »» Speaker, International Society for Clinical Densitometry meeting »» Speaker, Saudi Osteoporosis Society meeting »» Speaker, National Osteoporosis Foundation meeting »» Speaker, International Osteoporosis Foundation annual meeting, Seville, Spain »» Presenter, NIH ODS workshop on vitamin D, Bethesda, MD

Dr. Csaba Fekete »» Invited Speaker, Joint meeting of the Federation of European Physiological Society and Hungarian Physiological Society »» Speaker, Annual Meeting of the Hungarian Society for Endocrinology and Metabolism »» Editorial Board, Journal of Chemical Neuroanatomy

Dr. Andrew Greenberg »» NYU School of Medicine Solomon Berson Medical Achievement Award for Basic Research

Dr. Jacqueline Kung »» Member, Trainees and Career Advancement Committee, American Thyroid Association »» Chair, Information Technology Subcommittee, American Thyroid Association »» Member, Diabetes Clinical Advisory Committee, Tufts Medical Center and New England Quality Care Alliance »» Speaker, Medical Grand Rounds, University of San Diego »» Speaker, American Thyroid Association Annual Meeting Training Conference »» Volunteer Attending, Tufts Medical Student Free Clinic Sharewood Project

Dr. Ronald Lechan »» Organizing Committee and Co-Chair, Friedman Fellows Symposium on Nutrition and Human Health, San Francisco, CA »» Organizing Committee, International Pituitary Congress, Chicago, IL »» Editorial Board, Acta Biomedica »» Boston Magazine 2014 list of Top Doctors »» Top 10 Endocrinologists Award from American Registry »» External Expert, PhD Program in Molecular Medicine, University of Parma School of Medicine »» Member, International FIPA Consortium to study familial pituitary adenomas

47 Dr. Anastassios Pittas »» Chair, NIH Study Section on Clinical & Integrative Diabetes and Obesity »» Chair, NIH Special Emphasis Panel »» Visiting Professor, University of Kansas »» Speaker, 3rd International Conference on Vitamin D Deficiency, Abu Dhabi, UAE »» Speaker, American Diabetes Association, San Francisco, CA »» Speaker, Friedman Fellows Symposium on Nutrition and Human Health, San Francisco, CA »

» Dr. Aruna Saraswat ENDOCRINOLOGY, DIABETES AND METABOLISM AND DIABETES ENDOCRINOLOGY, OF DIVISION »» ABIM Certification in Endocrinology and Metabolism 2014

Dr. Richard Siegel »» Boston Magazine Best Doctors 2014

Dr. Jeffrey Tatro »» Inventor on licensing agreement pertaining to worldwide sales of α-MSH antiserum

Dr. Roberto Toni »» Scientific Director, Museum of Biomedical, Biotechnological and Translational Sciences, University of Parma »» Editorial Board and Section Editor on History of Endocrinology, L’Endocrinologo »» Member of Scientific Committee for the PhD Program in Molecular Medicine at the University of Parma School of Medicine »» Member of the Scientific and Clinical Committee of the Center for Sport and Exercise Medicine of the University of Parma

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 DIVISION OF GASTROENTEROLOGY

The Division of Gastroenterology was established in the 1960s under the direction of Dr. James Patterson, » » a dermatologist who became a gastroenterologist as GASTROENTEROLOGY OF DIVISION a result of his interest in the skin manifestations of digestive diseases. Dr. Marshall Kaplan, who had established a reputation at the NIH as an investigator of liver disease, succeeded Dr. Patterson as Division Chief in 1972. During Dr. Kaplan’s thirty year tenure, the Division became widely known for the management

Joel Weinstock, MD of primary biliary cirrhosis and sclerosing cholangitis and developed an academic and research focus. Dr. Kaplan also was an Associate Editor of the New England Journal of Medicine. In 2006, Dr. Joel Weinstock, who was well known for basic investigations of intestinal immunology, became Chief of the Division. His appointment brought novel approaches to the treatment of inflammatory bowel disease and a strong basic science interest in the mechanisms of immune regulation in the gut.

In 1984, the Division became one of the first awardees of an NIH Silvio O. Conte Digestive Disease Research Center grant. This basic research program, known as the GRASP Center, became the central link among digestive disease researchers throughout the medical center, the medical school and the veterinary school. The founding director of the GRASP Center was Mark Donowitz MD; Andrew Plaut became director in 1987.

Many former members of the Division have made major contributions to the field of gastroenterology and three have been presidents of the American Gastroenterological Association.

The members of the Division combine clinical and basic research talents. Members receive funding from the NIH and pharmaceutical industry and patients are referred from a network of internists and gastroenterologists throughout New England. Aside from the particular strengths in cholestatic liver disease and inflammatory bowel disease, the Division offers advanced endoscopic procedures for a variety of gastrointestinal disorders. The liver transplant program has merged with the program at Lahey Clinic so that the surgical procedures are now done at Lahey Clinic but the identification of candidates and the pre-and post-operative care remain at Tufts Medical Center. Highlights of 2014

»» John Leung, director for the GI food hypersensitivity center, has substantially expanded the service

»» Harmony Allison named director of our new GI motility service

»» Joel Mason awarded a grant from Prevent Cancer Foundation.

»» Hannah Lee awarded numerous grants to enhance her research program in Hepatitis

49 Faculty

Name Academic Rank Title and Special Responsibility

Joel V. Weinstock, MD Professor Division Chief Sanjay Hegde, MD Assistant Professor Director, Endoscopy Unit Harmony Alison, MD Assistant Professor Associate Director, Clinical Programs Martin Beinborn, MD, PhD Assistant Professor Peter Bonis, MD Adjunct Professor » » DIVISION OF GASTROENTEROLOGY OF DIVISION Moises Guelrud, MD Clinical Professor Lori Olans, MD Professor Instructor Jatin Roper, MD Assistant Professor Director, Food Allergy Center Assistant Professor, John, Leung, MD Medicine & Pediatrics Co-Director, Food Allergy Center at Floating Hospital for Children Allen Hwang, MD Assistant Professor Alan Kopin, MD Professor Director, Molecular Pharmacology Research Hannah Lee, MD Assistant Professor Director, Hepatology Programs Professor of Medicine and Nutrition; Director, Joel B. Mason, MD Professor Vitamins & Carcinogenesis Laboratory, USDA Human Nutrition Research Center at Tufts University Sonali Paul, MD Assistant Professor Andrew Plaut, MD Professor Kathleen Viveiros, MD Assistant Professor Director, Fellowship Program

Major Clinical Programs The clinical activities of the Gastroenterology Division of Tufts Medical Center include outpatient and inpatient management of gastrointestinal disorders and liver diseases. The Division has an international reputation in chronic cholestatic liver diseases and in inflammatory bowel disease, leading to referrals from worldwide.

The Division has special expertise in:

»» Esophageal motility studies and 24-hour pH monitoring of the esophagus »» Endoscopic treatment of Barrett’s esophagus »» Peptic ulcer disease »» Gastrointestinal endoscopy, including transduodenal bile duct and advanced pancreatic endoscopic therapy »» Colonoscopy and colonoscopic polypectomy, chromoendoscopy and magnification endoscopy »» Management of patients with chronic liver disease including chronic hepatitis, cirrhosis, gallstones, primary sclerosing cholangitis and primary biliary cirrhosis. »» Chronic cholestatic liver disease »» Inflammatory bowel disease

Physicians in the Division of Gastroenterology have pioneered innovative medical treatments for primary biliary cirrhosis and primary sclerosing cholangitis. These therapies appear to induce remission in some patients with previously untreatable disease.

Other interests include malabsorption disorders, and the clinical evaluation of nutritional disorders and weight loss; sexually transmitted intestinal and liver disease, including hepatitis and parasitic infections; and chronic secretory diarrhea. The inflammatory bowel disease clinic applies an interdisciplinary approach for the care of complex diseases including faculty from

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 the Departments of Colorectal Surgery, Radiology and Pathology. A wide spectrum of inflammatory disorder is handled with expertise including ulcerative colitis, Crohn’s disease, lymphocytic colitis, collagenous colitis and many others.

The GI motility service offers the latest technology for the study of motility problems of the gastrointestinal tract. Physician exports applying this advance technology aid in the evaluation of non-cardiac chest pain, gastroesophageal reflux disease, defecation disorders and more.

The Food Allergy Center at Tufts Medical Center and Floating Hospital for Children was established in 2013, in collaboration with the pediatric and adult GI Division. It provides integrative, patient-oriented, multidisciplinary care for both adults and children with known or suspected food allergies/intolerances. Division members treat diverse conditions like food anaphylaxis, »

eosinophilic esophagitis and eosinophilic gastroenteritis. » DIVISION OF GASTROENTEROLOGY OF DIVISION Teaching Activities The Division of Gastroenterology is extensively involved in the teaching of medical students. In the preclinical years, the division is responsible for the GI pathophysiology course. In the clinical years the division teaches students on both the Gastroenterology subspecialty floor and on the inpatient consultation service.

Interns and residents at Tufts Medical Center rotate through the GI subspecialty ward and may also choose an elective on the GI consultation service. These experiences expose residents to a wide variety of gastrointestinal disorders.

The Gastroenterology Fellowship Program is a joint fellowship program between Tufts Medical Center and St. Elizabeth’s Medical Center of Boston, both of which are affiliates of Tufts University School of Medicine. This collaboration has significantly enriched the educational experience of the teaching program. Most of the trainees seek academic careers.

Residents from Internal Medicine rotate through the Allergy Division. Those with a particular interest in Allergy and Clinical Immunology are given opportunities to participate in extra clinical sessions and are also encouraged to do literature surveys and extended evaluations of complicated patients. House staff members expressing interest in Allergy and Clinical Immunology have been supported in applications for fellowship training in Allergy and recent house staff members have been accepted to such fellowships in well-recognized programs including Scripps Clinic, Brigham and Women’s Hospital, Baylor College of Medicine and University of Virginia College of Medicine.

The staff has provided General Medical Associates with Educational Seminars in topics pertinent to Allergy. The staff regularly conducts consultations with Hospital Staff and physicians within the New England Quality Care Alliance, and educates dietary interns rotating through the Food Allergy Center on management of food allergies and food intolerances.

Community Outreach Programs Division staff has given presentations to schools, community health center, such as the YMCA, and on local TV and radio stations about the prevention and treatment of allergic diseases. The staff reaches out to the Mandarin and Cantonese speaking population of Boston through health fairs, seminars and educational articles in Chinese language newspapers like Sampan, to increase local awareness of the services offered by the Allergy Division.

Clinical Research

Recipient Funding Source Purpose of Award Prevent Cancer Foundation. Agricultural Research Service. Joel Mason, MD Inflammatory cytokines mediate the enhanced risk of colon cancer in obesity Nutrition and Cancer Prevention.

51 Basic Research

Recipient Funding Source Purpose of Award Division of Allergy, Immunology, and Transplantation (DAIT), A Prospective, Randomized, Double-blind, Placebo-controlled Phase II Clinical Harmony Allison, MD National Institute of Allergy and Study of Trichuris suis Ova Treatment in Left-sided Ulcerative Colitis and its Infectious Diseases (NIAID), Effects on Mucosal Immune State and Microbiota National Institutes of Health (NIH) A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-center

» Study to Evaluate the Safety and Efficacy of GS-9620 for the Treatment of » DIVISION OF GASTROENTEROLOGY OF DIVISION Virally-Suppressed Subjects with Chronic Hepatitis B A Phase 2, Randomized, Open-Label Study to Evaluate the Safety and Efficacy of GS-4774 in combination with Tenofovir Disoproxil Fumarate (TDF) for the Treatment of Subjects with Chronic Hepatitis B and who are currently not on Treatment A Long Term Follow-up Registry Study of Subjects Treated in A Gilead- Sponsored Trial with Chronic Hepatitis B Infection A Phase 2, Randomized, Open-Label Study to Evaluate the Safety and Efficacy Gilead Sciences, Inc. of GS-4774 for the Treatment of Virally-Suppressed Subjects with Chronic Hepatitis B A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Tenofovir Alafenamide (TAF) 25 mg QD versus Tenofovir Disoproxil Fumarate (TDF) 300 mg QD for the Treatment of HBeAg Positive, Chronic Hepatitis B Hannah Lee, MD A Phase 4, Randomized, Open-label, Active-Controlled, Superiority Study to Evaluate the Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) in Combination with Peginterferon α-2a (PegasysR) versus Standard of Care Tenofovir Disoproxil Fumarate Monotherapy or Peginterferon α-2a Monotherapy for 48 Weeks in Non-Cirrhotic Subjects with HBeAg-Positive or HBeAg-Negative Chronic Hepatitis B (CHB) A Randomized, Global, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Once-daily Oral Avatrombopag for the Eisai Co., Ltd Treatment of Adults with Thrombocytopenia Associated with Liver Disease Prior to an Elective Procedure A Phase 3 Randomised, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of S-888711 (Lusutrombopag) for the Treatment Shionogi, Inc ofThrombocytopenia in Patients with Chronic Liver Disease (CLD) Undergoing Elective, Invasive Procedures. The primary aims of this prospective, multi-center, longitudinal and exploratory pediatric and adult study are to determine the correlation of clinical outcome measures (patient reported outcomes, quality of life and National Institutes of Health endoscopy) with the established biomarker of peak mucosal eosinophil count (NIH) (Phase 1), and to compare the transcriptomes (eosinophilic esophagitis- transcriptome, eosinophilic gastritis-transcriptome and eosinophilic colitis- transcriptome) with their respective peak mucosal eosinophil counts and respective clinical outcome measures. Swiss National Science Foundation (grant no. John Leung, MD 32003B_135665/1) AstraZeneca AG (Switzerland) Aptalis The primary aim of this multicenter study is to develop, validate and evaluate Dr. Falk Pharma GmbH (Germany) an eosinophilic esophagitis activity index for pediatric and adult patients Glaxo Smith Kline AG Nestlé S. A. (Switzerland) The International Gastrointestinal Eosinophil Research

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Recipient Funding Source Purpose of Award The primary aim of this multicenter, double-blind, randomized, placebo- controlled study is to investigate the efficacy, safety, tolerability, John Leung, MD Regeneron Pharmaceuticals, Inc pharmacokinetic, and immunogenicity of dupilumab in adult patients with eosinophilic esophagitis. Study immune regulation in the gut pertaining regulatory T cells and how this NIH-RO1 DK 058755 adds the control of IBD »

Study the role of dendritic cells in the control of inflammation in the intestines » NIH-RO1-KD091987 GASTROENTEROLOGY OF DIVISION Joel Weinstock, MD and how it relates to IBD The Schneider Family IBD The Gilman Family IBD

Honors and Awards

Peter Bonis, MD. »» Investigator on a $6.2M five-year NIH grant (U54), awarded in 2014 (http://grantome.com/grant/NIH/U54-AI117804-01). It is aimed at studying various aspects of eosinophilic gastrointestinal diseases. »» Service on executive steering committees for The International Gastrointestinal Eosinophil (TIGERS), the Researchers and the Registry for Gastrointestinal Disorders (REGID, https://regid.org/), and the Consortium of Eosinophil Gastrointestinal Disease Researchers (CEGIRS, https://www.rarediseasesnetwork.org/CEGIR/index.htm

Moises Guelrud, MD »» Named in “Top Doctors” in Boston Magazine 2014 »» Invited Lecturer: Rings, Webs and Something Else. Tufts Medical Center, GI Conference 10/9/2014 »» Committee Assignments in Professional Societies: International Editor, GastroHep.com UK »» Attendance for Hand-On Course on Endoscopic Submucosal Disection, Brigham and Women’s Hospital. March 24, 2014

Joel Weinstock, MD »» “Top Doctors” on the Boston Magazine, 2014 »» Keynote speaker, 7th Vaccine Renaissance, Providence, RI, 2013. »» Invited speaker, Antigen Presentation and Host Defense-Bridging the Gap, University of Vienna, Vienna, Austria, 2014. »» Invited speaker and section chairman, 9th International Conference on Autoimmunity, Nice, France, 2014. »» Visiting Professor, Division of Gastroenterology, University of Arkansas, Little Rock, AK, 2013. »» Visiting professor, Department of Medicine and Division of Gastroenterology, University of Cincinnati, Cincinnati, Ohio, 2014. »» Visiting Professor, University of Antwerp, Belgium, 2014.

53 DIVISION OF GEOGRAPHIC MEDICINE AND INFECTIOUS » » GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION DISEASES

The Division of Geographic Medicine and Infectious Diseases at Tufts Medical Center is known for its excellence in clinical care, teaching, and research. The Division was created in 1957. Its first Chief, Dr. Louis Weinstein, was an internationally renowned clinician and teacher whose clinical acumen and charismatic teaching style attracted many young physicians to the relatively new subspecialty of infectious diseases. Graduates of his training program occupied significant positions in academia. During the tenure of his successor, Dr. Sherwood Gorbach, the cause and pathogenesis of C. difficile- David Snydman, MD associated disease were discovered by Drs. John Bartlett and Te-Wen Chang. In 2007, Dr. Gorbach was awarded the Alexander Fleming Prize, a lifetime achievement award, from the Infectious Diseases Society of America. Dr. Sheldon Wolff, the Chairman of Medicine at Tufts- New England Medical Center and an internationally recognized infectious disease expert (and Fleming Prize recipient), together with Charles Dinarello of the Experimental Medicine Division, discovered interleukin-1.

In 1986, the Divisions of Geographic Medicine, Experimental Medicine, and Infectious Diseases were merged into the Division of Geographic Medicine and Infectious Diseases. The chief, Dr. Gerald Keusch, was well known for his work on the pathogenesis of enteric infections, the effects of malnutrition on the immune response, and vaccine development. He, too, has been awarded the Fleming Prize by IDSA.

Dr. David R. Snydman became chief of the Division in 1998. Dr. Snydman is known for the first clinical description of Lyme disease, the first isolation of an organism consistent with B. burgdorferi from the joint of a patient with chronic Lyme arthritis, and the development of Cytomegalovirus Immune Globulin, which is used in transplantation. Dr. Snydman has expanded the division’s expertise in transplantation infectious disease, HIV care, and clinical research while maintaining the international programs and basic science focus in research. Under his leadership, the Division secured its’ fourth NIH training grant, this one in clinical research training in infectious diseases. In addition, the faculty has obtained 10 research career development awards from the NIH and 3 faculty career mentor awards, and trains 3-5 new fellows each year. Tufts University School of Medicine and Tufts Medical Center is the site for the editorial offices of Clinical Infectious Diseases, a journal of the Infectious Disease Society of America. The Editor and Deputy Editor and several Associate Editors are faculty members.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Highlights of 2014

»» Microbial Pathogenesis Training grant funded for another 5 years by the NIH (Linden Hu, Principal Investigator)

»» Shira Doron, MD, MS promoted to Associate Professor of Medicine

»» Alysse Wurcel, MD, MS joined the faculty with expertise in Hepatitis C treatment

»» Xin Li, PhD, with expertise in Lyme disease research, joined the division

»» Sherwood L. Gorbach, MD named Emeritus Professor Medicine by Tufts University School of Medicine

»» Susan Hadley, MD awarded the Natalie O. Zucker Prize from Tufts University School of Medicine for outstanding » » accomplishment in teaching DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION

»» Yoav Golan, MD, MS and Simone Wildes elected to Fellowship in the Infectious Disease Society of America

»» Helen Boucher, MD named to the American Board of Internal Medicine Subspecialty Board of Infectious Disease as well as the Board of Trustees of the Physicians Organization and the Board of Trustees of the College of the Holy Cross

Faculty

Name Academic Rank Title and Special Responsibility Chief of Division David R. Snydman, MD Professor Hospital Epidemiologist PI of Clinical Research Training Grant Director of OPAT (OutPatient Intravenous Antibiotic Therapy) Geneve Allison, MD Assistant Professor Program Robert Arbeit, MD Professor Consultation Attending, Idera Pharmaceuticals Jorge Barinaga, MD, MS Assistant Professor Milton Hospital consultant Michael Barza, MD Professor Vice Chair for Clinical Affairs, Department of Medicine Helen W. Boucher, MD Associate Professor Fellowship Program Director Victor Boyartchuk, PhD Assistant Professor José A. Caro, MD Assistant Professor HPV Clinic Jennifer K.L. Chow, MD, MS Assistant Professor Intercity Conference Director Antimicrobial Steward, Antimicrobial Management Program (AMT) Shira Doron, MD, MS Assistant Professor Associate Hospital Epidemiologist Yoav Golan, MD, MS Associate Professor Professor, Public Health Sherwood L. Gorbach, MD Emeritus Professor of Public Health and Medicine and Medicine Jeffrey K. Griffiths, MD, MPH&TM Professor Susan Hadley, MD Professor Pathophysiology Course Director James Hellinger, MD, MSc Assistant Professor Steven Y. Hong, MD, MPH, MAR Assistant Professor Vice Chair for Faculty Development, Department of Medicine Linden T. Hu, MD Professor Principal Investigator Microbial Pathogenesis Training Grant Co-Director, CTRC Michael R. Jordan, MD, MPH Assistant Professor Anne V. Kane, MD Assistant Professor Director, Phoenix Lab Laura Kogelman, MD Associate Professor Director of ID Clinic and Traveler’s Health Services Rakhi Kohli, MD, MS Assistant Professor Morbidity and Mortality Conference Director Xin Li, PhD Assistant Professor

55 Faculty (continued)

Name Academic Rank Title and Special Responsibility The Center for Vascular, Wound Healing, and Hyperbaric Medicine Natalie E. Nierenberg, MD, MPH Assistant Professor Transplant Infectious Diseases VAD Infections Roberta O’Connor, PhD Assistant Professor Debra D. Poutsiaka, MD, PhD Associate Professor »

» Co-director Mycobacterial Treatment Unit – Tufts MC GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION David R. Stone, MD Assistant Professor Attending Physician, and Director of HIV Research at Lemuel Shattuck Hospital Cheleste Thorpe, MD Associate Professor Institutional Biosafety Committee Chair Edouard Vannier, PhD Assistant Professor Associate ID Fellowship Program Director, Gretchen Volpe, MD, MPH Assistant Professor Antimicrobial Stewardship Director of Clinical HIV Research Program Associate Chair Dept. of Public Health Christine Wanke, MD Professor Director, Division of Nutrition and Infection Professor School of Nutrition Honorine D. Ward, MBBS Professor Program Director, HIV Pathogenesis Training Grant Simone Wildes, MD Assistant Clinical Professor Attending Physician, South Shore Hospital Alysse Wurcel, MD, MS Instructor IN Medicine HIV/HCV co-infection clinic

Teaching Activities The Division provides comprehensive teaching for all levels of the medical school and for postgraduate education. Dr. Susan Hadley is the director of the Infectious Disease pathophysiology course for the second year curriculum.

The fellowship program is comprehensive and includes training in transplant infectious diseases. From five to seven fellows are recruited each year. The program is supported by four NIH training grants, more than had by any other infectious disease training program in the United States. One grant is for microbial pathogenesis, one is for HIV pathogenesis, one is for clinical research training in infectious diseases, and one is for HIV clinical research. The training program is considered by the Infectious Disease Society of America to be a model for such programs.

The goal of the fellowship program is to train the next generation of academic infectious diseases specialists. The clinical training comprises 12 months of inpatient consultation and a weekly clinic supervised by infectious disease physicians. A rigorous didactic curriculum encompasses HIV medicine, nosocomial and community acquired infections, transplantation-related infections and infections acquired during travel. The second program year is devoted to research. Graduates of the program hold faculty positions at major academic medical centers, as well as at the United States FDA, CDC, and in the pharmaceutical industry.

Although the minimum training period is two years, the majority of fellows pursue an additional year of research training. The research program is funded by the NIH and provides a structured, supportive experience with formal mentorship by division faculty. Trainees also have the opportunity to obtain an MPH or MS and PhD degree in clinical research during fellowship, sponsored by the division. Outstanding research opportunities are available for fellows in basic, clinical, and translational research as shown on the website, http://www.tuftsmedicalcenter.org/OurServices/ InfectiousDiseases/?Page=8

Current and past fellows have competed successfully for NIH-sponsored loan repayment and mentored career development awards (K08, K23) that provide the foundation for a successful academic research career. There are a number of international opportunities for research in which fellows can participate. In the past year fellows have performed research in India, Africa, and Vietnam.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Research Activities State of the art research conducted by divisional faculty in bacterial, HIV, other viral and parasitic diseases spans basic science, clinical research, outcomes, and translational research both in the US and abroad. The annual research budget for the division exceeds $4 million. The tables below provide an indication of the scope of these awards.

Anne Kane, MD, manages the Phoenix Lab, a microbial products and services core facility for the Tufts community. The core services are all based on the growth of micro-organisms and include large and small-scale bacterial culture, protein expression and purification, preparation of complex bacterial media, and preparation of competent cells and plasmid maxipreps by the cesium gradient technique. In response to the Human Microbiome Project, Drs. Kane and » »

Ward have founded the Microbiota Working Group to encourage microbiota projects in the Division. Dr. Kane has added DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION services to the core which are designed to facilitate research such as DNA extraction from clinical samples and the subsequent generation and purification of PCR amplicons of 16S ribosomal DNA for deep sequencing.

Clinical Research Awards

Recipient Funding Source Purpose of grant NIH Chairperson, Clinical Endpoints Committee (CEC) Helen Boucher, MD Industry Endpoints Committees for several trials Center for AIDS Research Effect of oral Lactobacillus on Anal Dysplasia Biomarkers in HIV José A. Caro, MD (CFAR) 2014 Positive MSM Does weight loss surgery and probiotic supplementation lead to a lean Shira Doron, MD, MS Tufts Collaborates gut microbiota?

Role of Bile Acids in Human Susceptibility to Clostridium difficile NIH (R21) Infection Trends of Ceftaroline (CPT) Activity Among Consecutive Methicillin- Forest Labs resistant Staphylococcus aureus (MRSA) Blood Isolates and Correlation with Vancomycin (VAN) Activity Mortality and Hospital Length of Stay (HLOS) among Patients with Community-Acquired Pneumonia (CAP): A Propensity Score-Matched Forest Labs Yoav Golan, MD, MS, FIDSA Analysis of Ceftaroline fosamil (CPT-F)-Treated vs. Ceftriaxone-treated patients. Validation of a simple clinical rule to predict recurrence of infection by Merck & Co. C. difficile. Step 2: Defining risk factors for multiple recurrences (>=3) of C. difficile infection. A risk of recurrence-stratified comparison of fidaxomicin vs. vancomycin in adults with Clostridium difficile infection (CDI) and the cost- Cubist Pharmaceuticals effectiveness of fidaxomicin vs vancomycin or metronidazole in the treatment of infection by Clostridium difficile Antibiotic Spacer For Infected Joint Prostheses: A Pilot Study of Susan Hadley, MD, FIDSA CTSI Antibiotic Doses & Kidney Function Steven Y. Hong, MD, MPH, Namibia ART Patient Tracing Intensification and Predictors of Loss to NIH/NIAID (K23) MAR Follow-up

NIAID Clinical research training grant in infectious disease

David R Snydman, MD, US National Survey of susceptibility of Bacteroides fragilis, National Industry Sources FACP, FIDSA Survey of C. difficile antimicrobial susceptibility and epidemiology

R43 NIH/NIAID Molecular Diagnosis of Bacterial Pathogens in VAP

57 Clinical Research Awards (continued)

Recipient Funding Source Purpose of grant

Industry Studies on CMV Viral Load David R Snydman, MD, FACP, FIDSA (continued) Industry Probiotic Studies

Fogarty HIV and Nutrition Training Program with University of Namibia »

» Training Program in Innovations in Global Health (with Dr. H Ward and GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION Fogarty Christian Medical College) Joint Indo-US Collaborations, on HIV, ART, Intestinal Microbiota Food R21 and Nutrition Technical Assistance

USAID/WHO Funding to prepare Nutrition and HIV Guidelines

The Impact of Omega Three Fatty Acids on Vascular Function and cIMT R01 NIH/NHLBI Christine Wanke, MD in HIV Infected Individuals

R01 NIH/NICHHD Nutrition and HIV Progression

2 R01 NIH/NHLBI Protease Inhibitor Related Dyslipidemia

NIH/NIAID Brown-Tufts University Center for AIDS Research: Nutrition Core

Brown/Tufts/Miriam Fogarty AIDS International Training and NIH/Fogarty Research Program

Alysse Wurcel, MD, MS Industry Hepatitis C studies

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Basic Research Support In addition to clinical research, Division faculty carry out basic research in Lyme disease and babesiosis, cryptosporidiosis, and Shiga toxin.

Recipient Funding Source Purpose of grant Victor Boyartchuk, 5R21 AI097855-02 Analysis of TGSL, A Novel Regulator of Macrophage Survival PhD Physiological Interaction Between Probiotic Bacteria and Porphyromonas 5R01 DE024308-02 gingivalis » » R42AI078631 NIH Delivery system development for a reservoir targeted vaccine DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION Use of massively parallel sequencing for identification ofB. burgdorferi 5R21 AI103905-02 Linden Hu, MD, FIDSA virulence factors Role of carbon availability in environmental adaptation by Borrelia 1R21 AI111317-01 burgdorferi 5T32 AI007329-22 Infectious Disease Training – Pathogenesis/Host Response 5U01 AI109656-01 Searching for persistence in Lyme Disease NIH sponsored U01 subcontract Roberta O’Connor, Diverse Drug Lead Compounds from Bacterial Symbionts in from Oregon Health and Science PhD Tropical Marine Mollusks University Xin Li, PhD 7R01 AI103173-02 Critical Roles of Iron and Copper Detoxification inBorrelia Burgdorferi Roberta O’Connor, NIH Fogarty International Center Diverse Drug Lead Compounds from Bacterial Symbionts in Tropical Marine PhD 2U19TW00816306 Mollusks Bill and Melinda Gates An Integrated Human Enteroid Model of Environmental Enteric Dysfunction Foundation OPP1108228 Honorine D. Ward, MBBS 5R21 AI102813-02 O-Glycan Synthesis: Potential Targets for Intervention in Cryptosporidiosis 5D43TW009377-02 Tufts CMC Framework Program for Global Health Innovation NIH/NIA Babesiosis as a Model of Age-related Immunosenescence The Gordon and Llura Gund Identification of Genetic Determinants of Susceptibility to Babesiosis Family Foundation in Humans Edouard Vannier, PhD The National Research Fund for Host Resistance to Babesia microti infection, an Emerging Infectious Tick-borne Diseases Disease Tufts Collaborates/Tufts A novel genetic determinant of susceptibility to colonic inflammation University

Honors and Awards

Geneve Allison, MD, MS »» National Panel on Outpatient Antimicrobial Therapy (OPAT) Guidelines, IDSA »» Participant in national panel on OPAT Working Group: “The Value of ID-led OPAT”, IDSA

Helen Boucher, MD, FACP, FIDSA »» Education and Steering Committees, Mycoses Study Group »» Board of Directors, Infectious Diseases Society of America »» Clinical Trials Transformation Initiative, Bethesda, MD »» American Board of Internal Medicine Test Committee, Subspecialty Board of Infectious Disease »» American Board of Internal Medicine, Subspecialty Board of Infectious Disease »» Consulting Editor, Infectious Diseases Clinics of North America »» Editorial Board Antimicrobial Agents and Chemotherapy

59 »» ICAAC Program Committee »» Board of Trustees, College of the Holy Cross »» Committees: −− Member, Credentials Committee, Tufts Medical Center −− Member, Graduate Medical Education Committee and GME Quality Subcommittee, Tufts Medical Center −− Member, Admissions Committee, Tufts University School of Medicine −− Board of Trustees Tufts Medical Center Physicians Organization

»» A New Pathway for Antibiotic Innovation: Exploring Drug Development for Limited Populations, Pew Charitable Trust, Washington, DC » » GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION »» Mock Drug Development Exercise (CME), 41st Annual Postgraduate Course in Clinical Pharmacology, Drug Development and Regulation, Boston, MA »» ICAAC Fellows Program Faculty. 54th ICAAC, Washington, DC »» ID Quiz Team Leader, 54th ICAAC, Washington, DC »» New Antibiotics, ID week, Philadelphia, Pa »» Modernizing Antibacterial Drug Development and Promoting Stewardship. Brookings Council on Antibacterial Drug Development. Washington, DC »» Pros and Cons of Streamlined Development Programs for Antibacterial Drugs: Balancing Uncertainty and Risk with Patient Needs and the Practical Realities of Antibacterial Drug Development. NIH/FDA Workship: The Development of New Antibacterial Products: Charting a Course for the Future. Workshop, July 30-31, 2014 »» Visiting Professor, Providence Medical Center, Portland, Oregon

Jennifer K. Chow, MD, MS »» Scientific Affairs Committee, Tufts University School of Medicine

Shira Doron, MD, MS »» Planning Committee and Speaker, Improving Evaluation & Treatment of UTI in the Elderly: a Cross-Continuum Approach to Antibiotic Stewardship. December 2012-July 2014. Massachusetts.

Yoav Golan, MD, MS, FIDSA »» Elected to Fellowship, IDSA »» Influenza and Pneumococcal Vaccine Committee, Chairman »» The Australian Society of Antimicrobials Conference, Melbourne, Australia, February 22, 2014. Clostridium difficile- The Latest Hospital »» Scourge: Risk-Based Management Strategies with fidaxomicin »» GTC: ID World Summit 2014, 11th Anti-infective Partnering and Deal Making, Boston, MA July 9, 2014. Keynote Lecture: Antibacterials- The Gap »» PriMed East, Boston, MA, The Annual Primary Care Meeting, Pneumococcal vaccination, September 12, 2014

Susan Hadley, MD, FIDSA »» Awarded CTSI pilot grant to investigate AKI related to antibiotic impregnated spacers for treatment of prosthetic joint infections Natalie O. »» Zucker Award for Outstanding Accomplishment in Medical Education, Tufts University School of Medicine, 2014 »» Best Doctors 2014 »» Castle Connolly Top Doctor 2014 »» IDSA Program Committee 2014

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Steven Y. Hong, MD, MPH, MAR »» Member, Tufts Global Health Faculty Council »» Center for AIDS Research: HIV Prevention Core Faculty, Lifespan/Tufts/Brown Center for AIDS Research »» Center for AIDS Research Namibia Country Director »» Member, Republic of Namibia HIV Drug Resistance Technical Working Group »» World Health Organization (WHO) Consultant for HIV drug resistance in sub-Saharan Africa »» National Institutes of Health Clinical Research Loan Repayment »» Protocol Reviewer for Republic of Namibia Ministry of Health and Social Services Ethics and Research Committee (E&RC), » » GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION Linden T. Hu, MD, FIDSA »» Member, NIH study section (HIBP) »» Co-Director, CTRC

Laura Kogelman, MD »» 2014 Infectious Disease Attending of the year

Rakhi Kohli, MD, MS »» Women in Medicine Committee »» NIH Loan Repayment Award

Debra D. Poutsiaka, MD, PhD, FIDSA »» Best Doctors Selection »» Member, Research Committee, Infectious Disease Society of America »» Mentor, Learning Communities, Tufts University School of Medicine

David R. Snydman, MD, FACP, FIDSA »» Boston Magazine Best Doctors Selection 2014 »» Best Doctor’s in Amer ica Selection 2014 »» Castle Connolly Best Doctors Selection 2014 »» Editorial Board, Clinical Infectious Disease (Immunocompromised host section) »» Editorial Board, Transplantation »» Data Safety Monitoring Board for Chimerix (Brindcidofovir in stem cell transplant recipients) »» Data Safety Monitoring Board for Millenium Pharmaceuticals (vedolizumab) »» Data Safety Monitoring Board Genentech (CMV agent in renal transplantation) »» Consultant to Merck for Letermovir Development »» 54th ICAAC Symposium Anaerobes Not Your Orphan Organisms Any Longer: Antibiotic Resistance Among Bacteroides spp. and Evolving Multidrug Resistance, Washington, DC »» European Congress of Clinical Microbiology and Infectious Diseases Meeting Abstract Reviewer »» American Transplant Congress Meeting Abstract Reviewer

David Stone, MD »» Admissions Committee, Tufts University School of Medicine

Christine Wanke, MD »» Consortium of Universities for Global health, member, annual meeting planning committee »» Member, Vellore Christian Medical College, Foundation Board »» Invited Reviewer for King Foundation

61 Honorine D. Ward, MBBS »» Reviewer, NIH AIDS Opportunistic Infections and Cancer Study Section »» Chair, Vellore Christian Medical College Foundation Board »» Invited lecture: Drug Targets for Cryptosporidium. 16th International Conference on Emerging InfectiDiseases in ous the Pacific Rim. Dhaka, Bangladesh, February 2014 »» Invited lecture: Cryptosporidiosis: From Bench to Bedside and Beyond »» MassBiologics, Boston, MA April 2014

» Alysse Wurcel, MD, MS » GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES INFECTIOUS AND MEDICINE GEOGRAPHIC OF DIVISION »» NIH loan repayment award

Edouard Vannier, PhD »» Invited Lecture to the Boston Area Parasitology Symposium on “Immune basis for resolution of severe babesiosis”, November 2014. »» Reviewer for Emerging Infectious Diseases, Emerging Microbes & Infections, and PLoS One.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 DIVISION OF HEMATOLOGY/ONCOLOGY

The William Dameshek Division of Hematology/Oncology was established in the 1940s by Dr. William G. Dameshek, » »

a world-renowned hematologist and founder of the American Society of Hematology (ASH). HEMATOLOGY/ONCOLOGY OF DIVISION Schwartz assumed the directorship of the Division of Hematology and oversaw its merger in 1978 with the Division of Oncology. Dr. Schwartz conducted seminal studies demonstrating the feasibility of pharmacological immunosuppression, which ushered in the era of organ and marrow transplantation. In 1990, he became Deputy Editor of the New England Journal of Medicine. His successor, Dr. Bruce Furie, made major contributions to the fields of hemostasis and cell adhesion, and discovered P–selectin, an important platelet and vascular adhesion Andrew Evens, DO, MSc molecule. From 1998 to 2006, Dr. John Erban, an internationally recognized clinical breast cancer researcher, served as Division Chief, and was followed in 2006 by Dr. Richard Van Etten, who served in this role through 2013 and also was a founding Director of the Tufts Cancer Center He was succeeded in 2013 by Dr. Andrew Evens, an internationally recognized clinical and translational researcher in lymphoproliferative malignancies. Dr. Evens was appointed Director of the Tufts Cancer Center in 2014.

The Division has trained multiple hematology and oncology leaders. These individuals now head major cancer centers and divisions of hematology and oncology throughout the world. They hold leadership positions in professional societies including the American Society of Hematology, the American Society of Clinical Oncology, and the American Association of Blood Banks. Division faculty oversee the treatment of patients with a wide array of cancers in both ambulatory and inpatient settings and play a leading role in post-graduate education as well as clinical and translational research for the Tufts Cancer Center. Highlights of 2014

»» Dr. Andrew Evens became Director of the Tufts Cancer Center »» Two new faculty members joined the Division: Dr. Suriya Jeyapalan and Dr. Lori Pai; Dr. Jeyapalan is the new Director of the Tufts Neuro-Oncology Program and Dr. Lori Pai is a junior faculty Medical Oncologist with specialty in thoracic cancers and melanoma »» Six Division faculty were named to the “Best Doctors in Boston” list published annually by Boston Magazine »» A new cancer Electronic Medical Record (MOSAIQ®) uniting Hematology/Oncology, Pediatric Oncology, Radiation Oncology, and Gynecologic Oncology is integrated for patient care »» A Community Oncology Disparities Initiative continued with philanthropic support from the Yawkey Foundation, the Asian Healthcare Foundation of Massachusetts, and the Avon Foundation to support the creation of a Patient Navigation Program helping Tufts Cancer Center’s Asian population navigate their healthcare »» The Program for Adolescents and Young Adults with cancer and hematologic diseases enjoyed significant growth, with philanthropic support from the Reid R. Sacco AYA Cancer Alliance »» The clinical program on Cancer Fatigue and Holistic patient care was enhanced with philanthropic support from the Donaldson Family Trust »» A formalized Sickle Cell Program including outpatient day clinic was launched under the leadership of Dr. Hedy Smith »» The Division activated over 75 therapeutic clinical trials in cancer and hematology with cumulative budgets exceeding $5 million »» The Tufts Cancer Center was a partner and key participant with the Division of Pediatric Hematology/Oncology Floating Hospital for Children in 2014 for the annual Cycle for Life event for Tufts Medical Center »» Several philanthropic gifts were received in 2014 to support research programs as detailed below

63 Recent Cancer Center Gift Highlights Aid for Cancer Research Aid for Cancer Research awarded to John Erban MD and Naomi Rosenberg PhD representing (Tufts Medical Center and Tufts Medical School) a $145,000 Grant to fund a Fluorescence Resonance Energy Transfer (FRET) Microscopy unit in support of Research Scientists at MORI. The unit was dedicated in early 2014

John C. Davis Multiple Myeloma Program A seed pledge gift of $500,000 was generously given by John C. Davis to establish a Multiple Myeloma Program. Led by »

» Dr. Ray Comenzo, the program will focus on highly personalized and focused care in a multidisciplinary setting and HEMATOLOGY/ONCOLOGY OF DIVISION will be launched the Spring of 2015.

Julie Person Julie Person from Austin, TX gave a gift of $250,000 in support of Dr. Mathew’s Prostate Research Fund and in memory of her husband Will. Julie’s husband was treated by Dr. Mathew when he was at MD Anderson and followed him for his care when he joined Tufts Medical Center.

Reid R. Sacco Cancer Alliance The Reid R. Sacco Cancer Alliance made a $500,000 pledge to establish the Reid R. Sacco AYA (adolescents and young adults) Cancer Clinic. The Clinic, under the leadership of Dr. Susan Parsons, opened in 2013 and sees patients ages 18-39 for survivorship care. This gift was generously given by Gene and Lorraine Sacco and their son Weston, in memory of their son and brother, Reid Sacco, who lost his battle with Cancer.

Amyloidosis and Myeloma Research Program The Demarest Lloyd Jr. Foundation pledged a generous gift of $483,000 over three years in support of Dr. Comenzo’s research program.

Yawkey Foundation The Yawkey Foundation made a two-year pledge of $100,000 pledge gift to support a Patient Navigation Program helping Tufts Cancer Center’s Asian population navigate their healthcare. Over 4 years, the Yawkey Foundation has donated $200,000 in support of this program, which is led by Dr. Susan Parsons.

Avon Foundation The Avon Foundation, under its Safety Net Program, made a $100,000 donation to the Patient Navigation Program, allowing the program to expand its focus to patients of lower socio-economic status in addition to patients of Chinese or Vietnamese origin.

Asian Healthcare Foundation of Massachusetts The Asian Healthcare Foundation of Massachusetts provided the cancer center with a $50,000 donation to defray the full cost of hiring a multilingual patient navigator.

Cycle for Life The Tufts Cancer Center was a partner and participant with the Division of Pediatric Hematology/Oncology Floating Hospital for Children for the annual Cycle for Life event for Tufts Medical Center; in 2014, approximately $250,000 was raised.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibilities Chief, Division of Hematology/Oncology Andrew M. Evens, DO, MSc Professor Director, Lymphoma Program Director, Tufts Cancer Center Kenneth B. Miller, MD Professor Associate Chief, Division of Hematology/Oncology Eugene Berkman, MD Professor, Emeritus

Director, Hematology/Oncology Fellowship Program; » »

Rachel Buchsbaum, MD Associate Professor HEMATOLOGY/ONCOLOGY OF DIVISION Zaniboni Scholar in Breast Cancer Research Associate Director, Hemostasis and Thrombosis Research Diane Connolly, PhD Assistant Professor Laboratory Raymond Comenzo, MD Professor Director, Blood Bank and Stem Cell Processing Laboratory Associate Director, Hemostasis and Thrombosis Research Lidija Covic, PhD Assistant Professor Laboratory Associate Director for Clinical Science and Clinical Director, John K. Erban, MD Professor Tufts Cancer Center Suriya Jeyapalan, MD* Assistant Professor Director, Medical Neuro-Oncology Director of The Neely Cell Therapy Collection Center and Grace Shih-Hui Kao, MD Associate Professor Stem Cell Processing Laboratory Chairman, Institutional Review Board, Tufts Health Sciences Campus Director, Hematologic Malignancies Andreas Klein, MD Associate Professor Associate Director, Fellowship Program Acting Chairman and Principal Investigator, Cancer Center Tissue Repository Oversight Committee Director, Hemostasis and Thrombosis Athan Kuliopulos, MD, PhD Professor Research Laboratory Director, Center for Adaptation Genetics and Drug Stuart Levy, MD Professor Resistance, Tufts University School of Medicine Adjunct Associate Professor of Robert Martell, MD, PhD Leader, Hepatobiliary Tumor Boards Medicine Paul Mathew, MD Associate Professor Prostate Cancer and Genitourinary Malignancies Lori Pai, MD * Assistant Professor Attending Physician Associate Director for Population Science and Community Involvement, Tufts Cancer Center Director, Reid R. Sacco AYA Cancer Program Susan Parsons, MD, MRP Professor Director, Patient Navigation Program Director, Center for Health Solutions, Institute for Clinical Research and Health Policy Studies Program Director, GI Oncology Wasif Saif, MD Professor Program Leader, Experimental Therapeutics Zack Spigelman, MD Lecturer in Medicine Head and Neck Cancer and Rare Enzyme Disorders Senior Consultant in Hematology David Schenkein, MD Clinical Professor Chief Executive Officer, Agios Pharmaceuticals Robert Schwartz, MD Professor (Associate Staff) Emeritus Chief, Division of Hematology/Oncology Hedy Smith, MD, PhD Assistant Professor Director, Benign Hematologic Disorders Program

65 Faculty (continued)

Name Academic Rank Title and Special Responsibilities

Clinical Director, Leukemia Program Kellie Sprague, MD Assistant Professor Director, Bone Marrow and Hematopoietic Cell Transplant Program Associate Director, Hematology/Oncology Fellowship Gary Strauss, MD, MPH Professor Program Medical Director of Lung Cancer Program » » HEMATOLOGY/ONCOLOGY OF DIVISION Philip Tsichlis, MD Jane F. Desforges Professor Executive Director, Molecular Oncology Research Institute Lynne Taylor, MD Adjunct Associate Professor Neuro-Oncology and Palliative Care

*New faculty in 2014

Major Clinical Programs The faculty of the Hematology/Oncology Division supervises over 25,000 outpatient visits and treatments annually and oversees three complex inpatient services: the Bone Marrow Transplant/Hematologic Malignancies service, the Inpatient Oncology Service, and the Hematology/Oncology Consultation service. Clinical laboratory services under the direction of Division members include a blood bank with stem cell processing capability and a Special Hematology Laboratory that processes blood and bone marrow specimens for clinical and research purposes. The Neely Center Cell Processing and Collection Center provides state of the art services in cell collection, processing, and therapy, apheresis, and transfusion support for the entire Medical Center. The 20-bed infusion center provides state-of-the-art infusion support for chemotherapy, parenteral solutions, and antibiotics, in addition to education and psychosocial services. In addition, the Center for Extracorporeal Photopheresis provides novel therapy with a nationally recognized clinical research program in allogeneic stem cell transplantation and cell processing.

A Holistic and Integrative Therapy program was established in the Tufts Cancer Center primarily with funding from the Donaldson Charitable Trust Foundation. The Integrative Therapy program is led in part by Mary Beth Singer MS, ANP-BC, AOCN, ACHPN; it aims to decrease symptom distress, promote healing, and improve the overall experience of cancer treatment for our patients. Acupuncture and massage are provided free of charge to cancer patients each week through by certified clinicians from Pathways to Wellness. Additionally, an annual lectureship and patient-focused workshop on fatigue, related symptoms, and supportive therapies has been established and a program of research led by Nadine Linendoll, PhD, RN, was initiated focused on cancer related fatigue and the impact of integrative therapy on cancer.

The Reid R. Sacco Adolescent and Young Adult (AYA) Program for Cancer and Blood Diseases at Tufts Medical Center was established and launched in 2013. The AYA clinic, led by Dr. Susan Parsons, provides age-appropriate, comprehensive care in a designated physical space where our team can focus on both the clinical and transitional needs of cancer survivors ages 18-39 years. This program was started through generous support from the Reid R. Sacco AYA Alliance. This program represents one of the few such specialty programs in New England dedicated to the care of patients within this age group.

Multidisciplinary Cancer Care is the paradigm for cancer treatment offered by the Division. Division physicians participate in several multidisciplinary clinics with concurrent and coordinated care by multiple cancer specialists provide multispecialty care and access to psychosocial and genetic counseling. Included in this was the launch of a formalized Sickle Cell Program including outpatient day clinic in 2014 directed under the leadership of Dr. Hedy Smith; this program includes coordination with Tufts Medical Center Emergency Room and other key contributing services. Below are additional multidisciplinary programs at Tufts.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Multidisciplinary programs and clinics for cancer treatment (in 2014) include: »» Adolescent Young Adult Program for Cancer and Blood Diseases – Susan Parsons, MD, Director »» Benign Hematological Disorders Clinic – Hedy Smith, MD, PhD, Clinical Director »» Bone Marrow and Stem Cell Transplant Program – Kellie Sprague, MD Director »» Brain Tumor and Neuro-Oncology Program – Suriya Jeyapalan, MD, Director »» Breast Cancer and The Breast Health Center – Roger Graham, Director and John Erban, MD, Medical Oncology Director »» Genitourinary Malignancies Tumor Board – Paul Mathew, MD, Director »» Head and Neck Tumor Clinic – Zachary Spigelman, MD » » »» Hematologic Malignancies Program (Tufts Cancer Center) – Andreas Klein, MD HEMATOLOGY/ONCOLOGY OF DIVISION »» Hepatobiliary Tumor Clinic – Robert Martell, MD, PhD, Clinical Director »» Lung Cancer Multidisciplinary Clinic – Gary Strauss, MD, MPH, Clinical Director »» Lymphoma Program – Andrew Evens, DO, MS, Director »» The Neely Cell Therapy Center and Extracorporeal Photopheresis Program – Raymond Comenzo, MD, Director »» The Neely Center for Clinical Cancer Research – John Erban, MD, Medical Director »» GI Tumor Board – Wasif Saif, MD

Teaching Activities Faculty from the Hematology/Oncology Division participates extensively in the teaching of medical students, house officers, and fellows at Tufts Medical Center. Teaching of Tufts University School of Medicine (TUSM) students includes both preclinical lectures and clinical clerkship teaching. Dr. Rachel Buchsbaum is course director for the TUSM course entitled “Introduction to Hematology and Oncology, and serves as the Vice-Chair of the TUSM Curriculum Committee. Dr. Sprague serves as Preceptor for the Ambulatory Medicine Elective for TUSM 3rd year students in the Breast Health Clinic and is the Director of the Hematology- Oncology Clerkship for TUSM 4th year students. Dr. Susan Parsons is co-course director of the Public Health Integration course for 1st, 2nd, and 3rd year students in the combined MD/MPH program at TUSM. She also is course director of the Research Ethics course in the Clinical and Translational Science Graduate Program at the Sackler School of Graduate Biomedical Sciences at Tufts University (Sackler). Several faculty are mentors and thesis advisors for PhD graduate students enrolled in Sackler programs. Currently, there are 5 PhD students doing thesis research in laboratories/research programs of Division faculty.

The Division is also the home of the Hematology/Oncology Fellowship Training Program at Tufts Medical Center that is the centerpiece of Division teaching activities. As the Institute of Medicine and the American Society of Clinical Oncology have predicted a major physician shortage in hematology/oncology in the next decade, the Fellowship Program serves a critical educational need. Five clinical fellows per year are selected from over 300 applicants. The first year is devoted to clinical training in hematology and oncology, with an intense focus on ambulatory care. Members of the Division join physicians from other specialties and ancillary services to offer fellowship training and complex therapy in a multidisciplinary environment. In the second and third years of the Program, fellows are exposed to the inpatient consultation service and the bone marrow transplant/hematologic malignancies service, both of which provide essential clinical experiences and rigorous training in managing complex diseases while maintaining a continuity outpatient clinic one half-day per week. During their clinical year, fellows are exposed to the breadth of basic and translational cancer research at Tufts Medical Center through the MORI Lecture series, Cancer Center Grand Rounds, and direct contact with clinician-scientist faculty. These experiences allow fellows to begin to consider and plan research projects for their second year.

The research portion of the Clinical Fellowship begins in the second year. Typically, about half of the fellows in each class express an interest in basic and translational research, while the other half pursue clinical research projects. Under the supervision of an advisory committee, fellows make periodic presentations of their research progress to Division faculty. In the third year, the writing of at least one research paper that summarizes the trainee’s data and findings is a major priority. In 2014, 6 fellows in the Division presented their research work at national meetings and international meetings (Drs. Chaulagain, Kaul, Khagi, Kritharis, Pai, Shah), 3 fellows earned travel awards (Drs. Chaulagain, Kaul and Shah), and 2 fellows earned merit or achievement awards (Dr. Shah, Conquer Cancer Foundation Merit Award: Dr. Kritharis, American Society of Hematology Abstract Achievement Award).

A training grant from the National Cancer Institute (T32 CA09429), entitled “Research Training in Oncology”, supports the training of Hematology/Oncology fellows who pursue a basic or translational cancer research track. This grant is in its 31st continuous year.

67 Over 135 Hematology/Oncology Fellows have been trained in the Division, with approximately 40% of these trainees directly supported during their research years by the Training Grant. Of Program graduates, 20 are now Division Chiefs, head major programs at NCI–designated Cancer Centers or at the National Cancer Institute, or hold leadership positions at major pharmaceutical companies. Of 24 program graduates in the last 5 years, 16 are on the faculty of academic medical centers and one is a program leader in a major pharmaceutical company. Directed by Rachel Buchsbaum, MD, the Tufts Hematology/Oncology Fellowship program received a full 5-year accreditation with commendation by the Accreditation Council for Graduate Medical Education at its last site review in May 2010 and continuing subsequent accreditation under the ACGME Next Accreditation System.

Research Activities » »

HEMATOLOGY/ONCOLOGY OF DIVISION Faculty members and fellows of the Division of Hematology/Oncology as well as investigators at MORI continue vibrant research endeavors in cancer. Research spans the spectrum from basic, translational, and patient-oriented research to numerous therapeutic and interventional clinical trials in cancer and blood diseases. Below is a summary of these research efforts in 2014.

Clinical Research Clinical research in hematology and oncology takes the form of cooperative group trials, industry-sponsored trials, and investigator-initiated trials. Tufts Medical Center is a member of the Eastern Cooperative Oncology Group (ECOG), a prominent national clinical oncology research consortium. A number of the Division faculty serve in key leadership positions on ECOG committees and are principal investigators for ECOG National clinical trials (e.g., Dr. Evens leading NCT01216683: A 3-Arm Randomized Phase II Trial of Rituximab/Bendamustine (BR) Followed by Rituximab vs Bortezomib (Velcade®)-BR (BVR) Followed by Rituximab vs. BR Followed by Lenalidomide (Revlimid®)/Rituximab in High Risk Follicular Lymphoma). Dr. Parsons is a member of the study committee for Children’s Oncology Group trial AHOD1331, a randomized controlled trial of Brentuximab vedotin in the treatment of children and adolescents with high risk Hodgkin Lymphoma. She leads two embedded studies within the trial on chemotherapy-induced peripheral neuropathy and cost effectiveness analysis. Collectively, the Division has > 75 active therapeutic clinical trials in cancer and hematology and > 20 new cancer clinical studies are awaiting activation. Many of these clinical studies are “investigator-initiated” and are examining novel and targeted anti-cancer treatments (see table below). The cumulative budgets for these clinical studies total over $5 million with the annual clinical trial funding in 2014 based on patient accrual was over $600,000. This clinical research activity supports basic and translational research within the Division. All patients in the clinic and inpatient areas are asked to consent to donation of specimens (blood, bone marrow, biopsy material) for research purposes as part of an IRB–approved protocol, and these specimens are de–identified and banked. The Tissue Repository, a Core Facility of the Tufts Cancer Center, is a valuable resource for meeting the translational research interests of qualified Tufts Medical Center investigators. The following is a highlight of selected clinical cancer trials, with an emphasis on Investigator-Initiated Trials (IITs) that are being conducted within the Division. Clinical Research/Clinical Trials (partial listing)

Investigator Sponsor/Trial number Title Rachel Buchsbaum, Development of a minimally invasive biomarker for breast cancer Tufts CTSI MD development and metastasis. A Phase III randomized controlled open-label multicenter Safety and Efficacy Study Millennium Pharmaceuticals of Dexamethasone Plus MLN9708 or Physician’s choice of treatment administered to patients with relapsed or refractory systemic light chain (AL) amyloidosis A Multicenter Phase 2 Study of Single-agent Filanesib (ARRY-520) in Patients Array With Advanced Multiple Myeloma Raymond Comenzo, A Phase I, Open Label, Dose Escalation Study of Intravenous Administration of Prothena Biosciences MD Single Agent NEOD001 in Subjects with Light Chain (AL) Amyloidosis Phase II Study of the Combination of Bendamustine and Dexamethasone in Columbia University Patients with Relapsed AL Amyloidosis A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) Janssen in Combination With Backbone Treatments for the Treatment of Patients with Multiple Myeloma

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Investigator Sponsor/Trial number Title Raymond Comenzo, Randomized Phase III Trial of Lenalidomide Versus Observation Alone in ECOG-acrin MD Patients with Asymptomatic High-Risk Smoldering Multiple Myeloma NSABP B-49: A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy NRG Oncology Regimens for Women with Node-Positive or High-Risk Node-Negative, HER2- Negative Breast Cancer JNJ-212082 Randomized, Open-Label Study of Abiraterone Acetate (JNJ- 212082) Plus Prednisone With or Without Exemestane in Postmenopausal

Janssen » »

Women With ER+ Metastatic Breast Cancer Progressing After Letrozole or HEMATOLOGY/ONCOLOGY OF DIVISION Anastrozole Therapy A randomized double-blind, placebo-controlled study of LEE011 in combination with letrozole for the treatment of postmenopausal women with Novartis hormone receptor positive, HER2-negative, advanced breast cancer who received no prior therapy for advanced disease A Single Arm, Open-Label, Phase 2 Study of MGAH22 (Fc-optimized Chimeric Anti-HER2 Monoclonal Antibody) in Patients with Relapsed or Refractory Macrogenics Advanced Breast Cancer Whose Tumors Express HER2 at the 2+ Level by Immunohistochemistry and Lack Evidence of HER2 Gene Amplification by FISH John Erban, MD TESARO PR-30-5010-C (BRAVO): A phase III, randomized, open label, multicenter, controlled trial of niraparib versus physician's choice in Tesaro previously-treated, HER2 negative, germline BRCA mutation-positive breast cancer patients NSABP B-47: A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four NRG Oncology Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High- Risk Node-Negative HER2-Low Invasive Breast Cancer An Open Label Multicenter Phase 2 Window of Opportunity Study Evaluating Synta Pharmaceuticals Ganetespib (STA-9090) Monotherapy in Women with Previously Untreated Metastatic HER2 Positive or Triple Negative Breast Cancer Asian Americans with advanced cancer: preferences and care experiences CPPB The proposed research is to address the major gaps in our understanding of how to better meet the healthcare needs of Asian Americans with advanced cancer, a historically understudied population. Intergroup Randomized Phase 2 Four Arm Study In Patients With Previously ECOG-ACRIN Untreated Mantle Cell Lymphoma A Phase I-II Trial of Brentuximab Vedotin Plus Rituximab as Frontline Therapy Northwestern University for Patients With CD30+ and/or EBV+ Lymphomas A 3 Arm Randomized Phase II Trial of Bendamustine-Rituximab (BR) Followed ECOG-ACRIN by Rituximab vs Bortezomib-BR (BVR) Followed by Rituximab vs BR Followed by Lenalidomide/Rituximab in High Risk Follicular Lymphoma Andrew Evens, DO An Open-label, Multicenter, Phase 2 Study of Oral MLN9708 in Adult Patients Millennium Pharmaceuticals With Relapsed and/or Refractory Follicular Lymphoma A Phase II Trial of Sequential SGN-35 Therapy With Adriamycin, Vinblastine, Northwestern University and Dacarbazine (S-AVD) for Older Patients with Untreated Hodgkin Lymphoma A Single-Arm Phase II Clinical Trial with the Novel MEK Inhibitor AZD-6244 for University of Chicago the Treatment of MCT-1 Related Relapsed or Refractory Diffuse Large B-cell Lymphoma

69 Clinical Research/Clinical Trials (partial listing) continued

Investigator Sponsor/Trial number Title A Phase II Study of Umbilical Cord Blood Transplantation Following Tufts Medical Center Myeloablative or Reduced-Intensity Conditioning (PI Initiated) A Randomized Phase III Study of Bendamustine Plus Rituximab Versus Alliance for Clinical Trials in Ibrutinib Plus Rituximab Versus Ibrutinib Alone in Untreated Older Patients Oncology (>/= 65 Years of Age) With Chronic Lymphocytic Leukemia (CLL) A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline

» Millennium

» Therapy in Patients With Advanced Classical Hodgkin Lymphoma HEMATOLOGY/ONCOLOGY OF DIVISION A phase III, randomised, observer-blind, placebo-controlled, multicentre, clinical trial to assess the prophylactic efficacy, safety, and immunogenicity Glaxo SmithKline of GSK Biologicals™ herpes zoster gE/AS01B candidate vaccine when administered intramuscularly on a two-dose schedule to adult autologous haematopoietic stem cell transplant (HCT) recipients E1912: A Randomized Phase III Study of Ibrutinib(PCI-32765)-based Therapy vs Standard Fludarabine, Cyclophosphamide, and Rituximab ECOG-ACRIN Andreas Klein, MD (FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL). A Phase II, Safety and Efficacy Study of Fixed Dose Radioimmunotherapy (Zevalin, Yttrium-90 Ibritumomab Tiuxetan) for Patients with Incomplete Tufts Medical Center Response to Chemotherapy Prior to Autologous Stem Cell Transplant for Multiple Myeloma (PI Initiated) GS-US-339: A Phase 2, Open-Label Study Evaluating the Efficacy, Safety, Gilead Tolerability, and Pharmacodynamics of GS 9973 in Subjects with Relapsed or Refractory Hematologic Malignancies Plerixafor: Pilot Study of Lymphoid Tumor Microenvironmental Disruption Tufts Medical Center Prior to Autologous Stem Cell Transplantation (PI Initiated) E1A11: Randomized Phase III Trial of Bortezomib, LENalidomide and Dexamethasone (VRd) Versus Carfilzomib, Lenalidomide and Dexamethasone ECOG-ACRIN (CRd) Followed by Limited or Indefinite DURation Lenalidomide MaintenANCE in Patients with Newly Diagnosed Symptomatic Multiple Myeloma (ENDURANCE) Randomized clinical trial evaluating the impact of pretreatment Tufts CTSI with metformin on colorectal cancer stem cells (CCSC) and related Robert Martell, MD, pharmacodynamic markers PhD Prospective evaluation of clinical safety of combining metformin with Tufts CTSI anticancer chemotherapy PSMA ADC 2301: A Phase 2, open-label, multicenter study of PSMA ADC in Progenics Pharmaceuticals subjects with metastatic castration-resistant prostate cancer (mCRPC) TAXYNERGY: Phase II Trial to Evaluate Benefit of Early Switch from first-Line Docetaxel/Prednisone to Cabazitaxel/Prednisone and the opposite sequence, Sanofi-Aventis exploring molecular markers and mechanisms of taxane resistance in men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) who have not received prior chemotherapy A031201: Phase III Trial of Enzalutamide (NSC # 766085) versus Paul Mathew, MD Alliance Enzalutamide, Abiraterone and Prednisone for Castration Resistant Metastatic Prostate Cancer CALGB 90203: Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate CALGB Radical Prostatectomy in Patients With High-Risk, Clinically Localized Prostate Cancer HOG GU09-145: Phase I/II Study of BNC105P in Combination with Everolimus Hoosier Oncology Group or Following Everolimus For Progressive Metastatic Clear Cell Renal Cell Carcinoma Following Prior Tyrosine Kinase Inhibitors

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Investigator Sponsor/Trial number Title The proof of paradigm in CEA of Novel Therapeutics in treatment of Leukemia & Lymphoma Society hematologic malignancies. Patient Navigation of Newly Diagnosed Patients with Breast Cancer: Avon Foundation Susan Parsons, MD Surmounting the Cultural and Socio-economic Divide FDA Familial T-Cell Depleted Stem Cell Transplant in High-Risk Sickle Cell Anemia

Asian Healthcare Foundation Asian Patient Navigation in Cancer Care » » HEMATOLOGY/ONCOLOGY OF DIVISION Multicenter, Randomized, Double-blind, Phase 3 Study of Ramucirumab (IMC- 1121(B)) Drug Product and Best Supportive Care (BSC) versus Placebo and Imclone BSC as Second-time Treatment in Patients With Hepatocellular Carcimoma Following First-line Therapy With Sorafenib Phase 1 Study of the Anti-VEGFR-3 Monoclonal Antibody IMC-3C5 in Subjects Imclone With Advanced Solid Tumors Refractory to Standard Therapy or for Which No Standard Therapy is Available A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624 Combined with FOLFIRI as Second Line Gilead Treatment for Metastatic KRAS Mutant Colorectal Adenocarcinoma that Has Progressed Following a First Line Oxaliplatin- and Fluoropyrimidine-Containing Regimen STEAM (Sequencing Triplet with Avastin and Maintenance): Folfoxiri/ Genentech Bevacizumab Regimens (Concurrent and Sequential) vs. Folfox/Bevacizumab in First-Line Metastatic Colorectal Cancer Wasif Saif, MD Randomized, Open Label, Phase 2 Study of MM-111 and Paclitaxel with or without Trastuzumab in Patients with ‘Traditional’ and ‘Non-Traditional’ HER2 Merrimack Expressing Carcinomas of the Distal Esophagus, Gastroesophageal (GE) Junction and Stomach Who Have Failed Front Line Metastatic or Locally Advanced Therapy HALO: A Phase 2, Randomized, Multicenter Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Combined with nab-Paclitaxel Plus Halozyme Gemcitabine Compared With nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Previously Untreated Pancreatic Cancer A Randomized Phase 2 Placebo-Controlled Study of LY2495655 in Patients with Advanced or Metastatic Pancreatic Cancer Receiving Chemotherapy TAS102-106 Eli Lily TAS102-107 Pre-ECOG Gem-Abraxane in Cholangiocarcinoma LAPAC Study: Gem-A braxane in LA PC Translational Study of the Efficacy of Novel Compounds in Erythrocytes Agios Pharmaceuticals Affected by Pyruvate Kinase Deficiency or Chronic Hemolytic Processes Hedy Smith, MD, PhD Selexys Pharmaceutical SelG1-00005 trial: Antibody Targeting P-Selectin in Sickle Cell disease Inspirations / Baxter Phase II study of Recombinant Porcine factor VIII (OBI-1) for treatment of Pharmaceuticals Acquired Hemophilia A

71 Clinical Research/Clinical Trials (partial listing) continued

Investigator Sponsor/Trial number Title Research Sample Repository for Allogeneic Unrelated Hematopoietic Stem National Marrow Donor Program Cell Transplantation A Research Database for Hematopoietic Stem Cell Transplantation, Other National Marrow Donor Program Cellular Therapies, and Marrow Toxic Injuries E2906: Phase III Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose

» ECOG-ACRIN Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. » HEMATOLOGY/ONCOLOGY OF DIVISION Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age Kellie Sprague, MD >60 Years) Amgen 00103311: A Phase III, Randomized, Open Label Study Investigating the Efficacy of the BiTE Antibody blinatumomab versus Chemotherapy in Amgen Adult Subjects with Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) A Phase 1b Study to Evaluate the Safety and Preliminary Efficacy of PF- 04449913, an Oral Hedgehog Inhibitor, in Combination with Intensive Pfizer Chemotherapy, Low Dose Ara-C, or Decitabine in Patients with Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Basic/Translational Research Division members collaborate with a variety of prominent and talented researchers and research institutes throughout the Tufts campuses. The basic and translational cancer research activities at Tufts Medical Center are based in the Molecular Oncology Research Institute (MORI). The Institute, now in its 13th year, serves as the focus for basic and translational cancer research within Tufts Medical Center. MORI occupies more than 33,000 square of its 75 Kneeland Street building. It has 18 faculty members, including five clinician-scientists, and employs about 65 FTEs. Its mission is to explore the molecular mechanisms of neoplastic transformation and to promote the translation of basic research findings into the clinic. To achieve this goal, MORI scientists carry out research that spans the spectrum from gene discovery to target validation for drug development. MORI investigators have received over 180 grants and published over 350 papers since the Institute began. Current Division faculty with research laboratories at MORI include: Drs. Buchsbaum, Covic, Kuliopulos, Mathew, Tsichlis, and Evens.

In 2014, investigators at the Molecular Oncology Research Institute (MORI) gave more than 40 invited lectures, produced more than 50 peer reviewed research publications, and faculty received 7 new research awards (totaling $1.23 million). Furthermore, in 2014, MORI faculty research was supported by >10 peer-reviewed grants from the NIH, DOD, and various foundations and industry sponsors. Faculty research spans the spectrum from basic, translational, and patient- oriented research to numerous therapeutic and interventional clinical trials in cancer and blood diseases.

The Cummings School of Veterinary Medicine at Tufts University (TCSVM) is the only veterinary school in the New England region providing high-quality clinical care services and original research. The research includes shared models to study cancer in animals that may have direct application to humans (i.e., Comparative Oncology). Researchers at TCSVM are members and active participants of the National Cancer Institute Clinical Oncology Trials Consortium. They have contributed to numerous clinical trials utilizing dogs, cats, and other small animals with various spontaneous cancers to inform human cancer therapy. Likewise, they have succeeded in establishing and participating in a national effort to collect and bank cancer tissue for post hoc research through the Canine Comparative Oncology Genetics Consortium. Though these and other collaborations, the TCSVM have established their abilities to conduct critically important comparative oncology research studies.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 The Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University is a unique national resource and asset devoted to diseases of an aging population, including cancer. The HNRCA is operated by Tufts University through a cooperative agreement with the Agricultural Research Service (ARS), and is one of six human nutrition research centers in the United States. It is supported by the United States Department of Agriculture (USDA). The HNRCA is a recognized leader in nutritional research and occupies a 14-story building on the Health Sciences campus. The interaction between nutrition and the onset and progression of cancer has been a special interest of several scientists at the HNRCA. These investigators use cell and molecular biology techniques, genomics, and sophisticated animal models. The focus on Cancer within the HNRCA was bolstered when cancer was selected in 2011 as an area of future emphasis and investment for the Center, triggering the formation of a Cancer–Cluster within the HNRCA. This »

Cluster, headed by Dr. Jimmy Crott, a faculty member of this Training Program, is the focus of increased cancer » HEMATOLOGY/ONCOLOGY OF DIVISION collaborations and investments.

Additionally, the Division is pleased to have arranged a scientific collaborative relationship with Northeastern University (NU) as a research partner for the Division of Hematology/Oncology and the Tufts Cancer Center. Tufts has had a close research relationship with NU over the past 10 years in particular with the Tufts CTSI. Collaborations with the NU School of Science are focused in the Departments of Pharmaceutical Sciences and of Chemistry and Chemical Biology. Graham Jones, PhD, DSc (Chair of Department of Chemistry at NU) was named Associate Director of the Tufts CTSI in 2013 charged as leader of T1 research for the CTSI. Dr. Jones is also a member of the Tufts Cancer Center Research Executive Committee. In addition Dr. Jones and 6 other NU faculty now serve as mentors or co-mentors for the Tufts Hematology/Oncology T32 program (i.e., Dr’s Amiji, Chen, Karger, Murthy, Sitkovsky, and Torchilin). The programs led by these faculty members are focused on the discovery, design, and use of drugs—finding new targets for drug development, researching how drugs work at a molecular level and the harmful effects of drugs, and determining how drugs’ properties, dosages, and delivery systems affect their performance. In addition, the integration of NU adds significant and unique research resources to the Hematology/Oncology T32 such as state-of-the-art proteomics as well as a Center of Cancer Nanotechnology Excellence.

Laboratory/Translational Research Grants (partial list)

Investigator Funding Source Grant title Tufts Clinical and Translational Identifying factors regulating the Tiam-1 osteopontin pathway in the breast Science Institute cancer microenvironment. Department of Defense CDMRP Development of Technologies for Early Detection and Stratification – Breast Cancer of Breast Cancer Rachel Buchsbaum, MD Diane Connolly-Zaniboni Resarch Scholarship in The role of Tiam-1 in the tumor microenvironment. Breast Cancer Russo Family Pilot Project, Tufts In vivo investigation of stromal Tiam1 effects on breast cancer stem cells. University Raymond Comenzo, Lymphoma Foundation Applications of Proteasome Inhibition in Clonal Plasma Cell Diseases. MD EMR Adverse Drug Event Detection for Pharmacovigilance (subcontract): This multicenter projects aims to refine/improve existing Bio-Natural Language NIH/NCI Processing (Bio-NLP) and develop new innovative BioNLP algorithms order to identify serious adverse events during cancer treatments Andrew Evens, DO MAP Kinase Signaling in Lymphoma: A Novel Therapeutic Paradigm: The goal of the proposed research project is to investigate the biology and clinical NIH/NCI efficacy of targeting the MAP Kinase MEK/ERK pathway in lymphoma through in vitro and in vivo mouse models as well as through an early-phase clinical trial in relapsed/refractory non-Hodgkin’s lymphoma (DLBCL).

73 Laboratory/Translational Research Grants (partial list) continued

Investigator Funding Source Grant title Computerized quantitative imaging assessment of tumor burden: A multidisciplinary team has been assembled comprising radiologists, NIH/NCI informaticians, and oncologists, including an industrial partnership with General Electric (GE) Medical Systems to integrate and analyze a spectrum of quantitative imaging biomarkers (e.g., quantitative PET). Research Training in Oncology: This training grant supports basic and

» NIH/NCI (T32) translational cancer research by hematology/oncology fellows at Tufts Medical » HEMATOLOGY/ONCOLOGY OF DIVISION Center in their second and third years of fellowship training. A Single-Arm Phase II Clinical Trial with the Novel MEK Inhibitor AZD-6244 University of Chicago and Andrew Evens, DO for the Treatment of MCT-1 Related Relapsed or Refractory Diffuse Large NIH/NCI (continued) B-cell Lymphoma A Phase II Trial of Sequential SGN-35 Therapy With Adriamycin, Northwestern Univ./ Vinblastine, and Dacarbazine (S-AVD) for Older Patients with Seattle Genetics Untreated Hodgkin Lymphoma A Phase I-II Trial of Brentuximab Vedotin Plus Rituximab as Frontline Therapy Northwestern Univ. / for Patients With CD30+ and/or EBV+ Lymphomas Seattle Genetics An Open-label, Multicenter, Phase 2 Study of Oral MLN9708 in Adult Patients With Relapsed and/or Refractory Follicular Lymphoma Genzyme Lysomal Disorders Fellowship Programmatic Support Characterization of a naïve T-cell (CD45RA)-depleted stem cell graft for CTSI Catalyst Award allogeneic stem cell transplant with reduced risk for graft-versus-host disease Andreas Klein, MD Construction and Evaluation of Novel Palmitoylated Peptides (Pepducins) Charlton Fund, TUSM Targeting ZAP70 Signaling in Chronic Lymphocytic Leukemia NIH/NHLBI Stage 2 TRIP: PAR1 Pepducin-Based Interventions in Arterial Thrombosis NIH/NIAID The Multiple Antibiotic Resistance (mar) regulon Stuart Levy, MD 5R01 AI056021 USDA 2011-67019-30187 Microbial community activity: communication among soil microbes Robert Martell, MD, CTSI High Impact Project Metabolism and Cancer PhD Pfizer Center of Technology Development of angiogenin receptor antibodies as prostate cancer Innovation Award therapeutic Paul Mathew, MD Agency for Healthcare Research Role of active surveillance in the management of early stage, low-risk prostate and Quality (AHRQ) Task Order cancer #10 NIH/NCI Tpl2 in intestinal tumorigenesis R01 CA124835 Philip Tsichlis, MD NIH/NCI Akt in T cell development and function 5R01 CA057436 CTSI NDY1/DKM2B Development of an enxymatic assay and initial screening for inhibitors Wasif Saif, MD CTSI Effect of Metformin on Cancer.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Honors and Awards (partial list)

Dr. Buchsbaum »» Tufts University School of Medicine, Outstanding Lecturer »» Tufts University School of Medicine, Accomplished Teaching »» Invited speaker, AACR Meeting, April 2014. Tiam1 and the Breast Cancer Microenvironment

Dr. Comenzo »» Boston Magazine, Best Doctors 2014 » » »» Top Doctor, Hematology, Castle Connolly HEMATOLOGY/ONCOLOGY OF DIVISION »» 2014 Physician Humanitarian Award, ROFEH International »» Founding Director and Co-Chairman, Amyloidosis Research Consortium (ARC) »» Invited Speaker – Advances in Diagnosis and Treatment of Systemic AL Amyloidosis. Columbia University Medical Center. New York, NY. »» Invited Speaker - When are Alternatives to High Dose Chemotherapy Reasonable? Amyloidosis: Should Our Treatment Approaches Be More Personalized? 2014 BMT Tandem Meetings, Dallas, TX. »» Invited Speaker – Risk Management in Plasma Cell Neoplasms. ECOG-Acrin Annual Meeting. Chicago, IL. »» Invited Speaker – Amyloidosis 2014: Use the Tools We Have and Save Lives. Heart Failure and Transplant Consortium Dinner Meeting. Massachusetts Medical Society, Waltham Woods, MA. »» Invited Speaker – Mastering Clinical Challenges in Relapsed Refractory Multiple Myeloma. Myeloma Workshop. North Arlington, VA. »» Invited Speaker – Overcoming Challenges in the Treatment of Multiple Myeloma. Myeloma Workshop. Houston, TX. »» Invited Speaker – Smoldering myeloma - Who and when to treat: Should smoldering high risk myeloma be immediately treated? MetroWest Medical Center. Natick, MA.

Dr. Erban »» Member, Tufts-China-Taiwan Delegation February 2014 (with Dean Harris Berman, Trustee Olivia Cheng, Philip Hinds, John Erban, Rebecca Scott) »» Associate Editor, American Journal of Clinical Oncology »» Medical Editor Tufts MedicineBoston Magazine, Best Doctors –Oncology 2014 »» Tufts Medical School Teaching Recognition Award -3rd Year »» Vitals Top 10 Doctors by State.-2014 »» Castle Connolly America’s Top Doctors for Cancer 2014 »» Patient’s Choice Award- 2014

Dr. Evens »» Hodgkin Lymphoma Working Group- primary member: NIH/NCI Steering Committee Subgroup »» Primary/voting member, Developmental Therapeutics committee, ECOG »» Primary/voting member, Protocol Review Committee and Data Safety and Monitoring Committee, Tufts Cancer Center, Boston, MA »» Clinical Trial Design & Development Working Group, Quantitative Imaging Network (QIN) with CTEP and NIH »» Chair, New England Lymphoma Rounds Steering Committee (Sponsor: Lymphoma Research Foundation) »» Member, Scientific Advisory Board (SAB), for Lymphoma Research Foundation (LRF) »» Primary Hematology Review Panel (Standing Member and Chair), for VA Scientific Merit Review (R01). NIH and NCI »» Faculty member – European School of Oncology and Ulm University. Certificate of Competence in Lymphoma (CCL) programme. Post-transplant lymphoproliferative disorder »» Faculty member/mentor. MIT-Tufts Physician Shadow Program

75 »» Faculty member/mentor (Group Leader), Lymphoma Research Foundation (LRF) Annual Mentoring Program »» Associate Editor, British Journal of Haematology »» Senior Editorial Board, American Journal of Blood Research »» Editorial Board, Leukemia Research »» Editorial Board, Journal of Clinical Oncology »» Co-Chair, Tenth International Ultmann Symposium on the Diagnosis and Management of Lymphoma, The University of Chicago and The Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Mary 2nd and 3rd, 2014 »» Co-Chair, Tufts Cancer Center Pharmacy and Therapeutics (P&T) Committee, Tufts Medical Center, Boston, MA » »

HEMATOLOGY/ONCOLOGY OF DIVISION »» Invited Speaker – Highlights of ASH in North America. Topic: Hodgkin Lymphoma; Atlanta, GA, January 25th, 2014; and Seattle, WA; February 1st, 2014 »» Invited Speaker – Lymphoma Research Foundation (LRF) Mentoring Program. Grant opportunities and funding mechanisms for clinical investigators in the field of lymphoma; Scottsdale, AZ; February 7th, 2014 »» Invited Speaker – St. Luke’s Hospital Oncology Grand Rounds. The Prognosis and Treatment of Hodgkin Lymphoma: Long Term Considerations (i.e., Survivorship). New Bedford, MA; February 19th, 2014 »» Invited Speaker – Aggressive Non-Hodgkin Lymphoma; New England Lymphoma Workshop (Patient Forum); Boston, MA, March 22nd, 2014 »» Invited Speaker – Highlights of ASH in Asia. Topic: Hodgkin Lymphoma; Singapore, Asia; March 29th and 30th, 2014 »» Invited Speaker – Controversial Cases in Hematologic Malignancies and Hematology; Prognosis and Treatment of Peripheral T-cell Lymphoma (Sponsor: Massachusetts General Hospital). Boston, MA; April 12th, 2014 »» Invited Speaker – Hematological malignancies in pregnancy; International Consensus Conference, UZ Louven University, Louven, Belgium, May 22-23, 2014 »» Invited Speaker – Peripheral T-Cell Lymphomas: Contemporary Prognostic and Therapeutic Approaches; Oncology Grand Rounds; Lahey Clinic; Burlington, MA; May 29th, 2014 »» Invited Speaker – Arterial Disease, Second Cancers, and Other Aftermath in Hodgkin Lymphoma; Lowell General Hospital Grand Rounds; Lowell, MA, June 11th, 2014 »» Invited Speaker – Hodgkin Lymphoma in Older (Elderly) Patients, Pathology Working Group and the Subtypes Initiative, Roundtable discussion on the state-of-the-art pathology and future initiatives; INTERLYMPH 2014 Annual Meeting. UCLA, Los Angeles, CA, June 18th, 2014 »» Invited Speaker – Impact of Lifestyle on Lymphoma Histology and Genetics, Lifestyles and Environment Working Group INTERLYMPH 2014 Annual Meeting. UCLA, Los Angeles, CA, June 19th, 2014 »» Invited Speaker – Update on Lymphoma; Best of ASCO 2014 (Sponsor: ASCO); Chicago, IL; August 16th, 2014 »» Invited Speaker – The Prognosis and Treatment of Hodgkin Lymphoma: Past, Present, and Future Directions, Lymphoma/Myeloma Hematology Grand Rounds, MD Anderson Cancer Center; Houston, TX; August 16th, 2014 »» Invited Speaker – Antibody Drug Conjugates in Lymphoma, New Therapeutic Advances in Hematologic Malignancies/Diseases; Lahey Cancer Center Grand Rounds; Burlington, MA; October 23rd, 2014 »» Invited Speaker – ASH Educational Lecture: The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. 56th Annual ASH Meeting, December 2014 »» ASH 2014, Oral Presentation: Rosenberg AS, Klein AK, Ruthazer R, Evens AM. Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder (HL-PTLD) after Solid Organ Transplant (SOT): A Comprehensive and Comparative Analysis of Disease Characteristics, Prognosis, and Survival.

Dr. Klein »» Top Doctor, Castle Connolly »» Member, New England Lymphoma Rounds Steering Committee (Sponsor: Lymphoma Research Foundation; www.lymphoma.org/nelr) »» Member, CTSA Consortium Consensus Scientific Review Committee (SRC) Working Group »» Host, BMT Online Journal Club »» Invited Speaker – Massachusetts Association of Blood Banks

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» Invited Speaker – Tufts CTSI Translational Research Day, Regulatory Panel »» Invited Speaker – Tufts Dental School, Research Ethics »» Organizer and Invited Speaker – Blood Cancer Symposium, Leukemia & Lymhoma Society, Natick, MA

Dr. Kuliopulos »» Appointed Director of the Center of Hemostasis and Thrombosis Research, Tufts Medical Center »» Invited Speaker, Webinar: SMARTT Program, NHLBI; Overcoming Barriers to Early Translation in Therapeutics Development: Development of PZ-128 for the prevention of Arterial Thrombosis in acute coronary syndromes and percutaneous coronary

intervention, May 28, 2014 » » HEMATOLOGY/ONCOLOGY OF DIVISION »» Invited Speaker, Chemistry Department, UC Santa Cruz, CA; Medicinal Chemistry and Drug Development with Cell-penetrating Pepducins:, July 25, 2014 »» Invited Speaker, Discovery on Target: Membrane Protein Targets, 2014, ìTargeting Receptors with Cell Penetrating Pepducins: From Bench to Bedside, Boston, MA, Oct 10, 2014 »» Invited Speaker, Boston Angiogenesis Meeting, ìMatrix Metalloprotease Signaling in Tumor Angiogenesisîs, Boston, MA, Nov 12, 2014 »» Elected member of NIH/NHLBI Scientific Review Board SMARTT Program.

Dr. Levy »» Lecture and Panel Discussion, May 2014 in Washington D.C.: “Antimicrobial Resistance: a problem without borders” at the Institute of Medicine-May 2014 »» Participated in the Group Summit Meeting in London on issues of antibiotic resistance in the community Global Respiratory Infection Partnership(GRIP)- June 2014 »» “Modernizing antibacterial drug development and promoting stewardship” Lecture and discussion at the Brookings institution Washington DC on the problem of antibiotic resistance and the increasing need for stewardship -February 2014 »» Received lifetime recognition plaque for nine years of support for the National Science Advisory Board for Biosecurity at the National Institute of Health (2005-2014)

Dr. Matthew »» Boston Magazine Best Doctors 2014

Dr. Miller »» Boston Magazine Best Doctors, 2014 »» Invited Lecture – Lovering Lecture – Memorial Hospital of Rhode Island »» Invited – Oncology Tumor Board – Newton Wellesley Hospital

Dr. Parsons »» Invited Plenary Speaker, “Improving Health in an Urban Asian Population: Patient Navigation for Patients of Chinese Origin with Newly Diagnosed Breast Cancer”. Avon Foundation for Women Biennial Breast Cancer Forum), Washington, DC. »» Invited Speaker, Predictors of overweight and obesity in survivors of childhood cancer. American Institute for Cancer Research Annual Research Conference on Food, Nutrition, Physical Activity, and Cancer (Invited Speaker), Washington, DC. »» American Cancer Society, Palliative Care and Symptom Management Peer Review Committee, Invited Grant Reviewer »» Castle Connelly Top Doctor in Pediatric Hematology-Oncology

Dr. Saif »» America’s Top Doctors »» America’s Top Doctors for Cancer »» Compassionate Doctor Recognition »» Patients' Choice Award »» AFIP Award

77 »» AFPGMI Award »» Invited lectures, courses, symposia (national, international, universities, etc) »» University of Cincinnati »» AACR workshop focused on the use of metformin in clinical trials »» King Edward Medical University »» Armed Forces Post Grad Med. Institute »» Armed Forces Institute of Pathology »» Wah Medical College » »

HEMATOLOGY/ONCOLOGY OF DIVISION »» Dana Farber Cancer Institute. Grand Rounds »» Portsmouth Regional Medical Center »» Vyas O, Keith L, Saif MW. Clinical Outcomes in Pancreatic Adenocarcinoma Associated with BRCA2 Mutation. Pancreas Club, 2014. »» Abrahams M, Knisely J, Huber K, Saif MW. Safety and Efficacy of Capecitabine in Adjuvant Treatment of Pancreatic Cancer. ASTRO. 2014 »» AACR Metformin Symposium, New Oreleans. Oct 2014

Dr. Hedy Smith »» Boston Magazine, Best Doctors, 2014 »» Cancer Medicine and Hematology DFCI/Cancer Care Course, Boston; September 2014

Dr. Sprague »» Boston Magazine, Best Doctors, 2014 »» U.S. News & World Report, Top Doctors 2014 »» Advisory Board, OncLive »» Invited speaker; Current Treatment and Trends in Acute Leukemia, Blood Cancer Conference, Leukemia and Lymphoma Society, MA, 2014 »» Invited speaker: Current Treatment of Myelodysplastic Syndrome, New Therapeutic Advances in Hematologic Malignancies, MA. 2014 »» Invited speaker: Case of an Insidous Rash, Medical Grand Rounds. Tufts Medical Center

Dr. Zachary Spigelman »» Boston Magazine Best Doctors, 2014

Dr. Strauss »» Boston Magazine Best Doctors, 2014

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 79 DIVISION OF INTERNAL MEDICINE AND ADULT PRIMARY CARE » » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION The Division of Internal Medicine and Adult Primary Care at Tufts Medical Center is the principal clinical home for adult internal medicine, family medicine, geriatrics and transitional care medicine. The division contains six sections, described below.

General Medical Associates (GMA) comprises multiple ambulatory internal medicine practices and is the primary care teaching practice for the Tufts Internal Medicine Residency. All of the physicians are internists or family practitioners and many have both a research, quality or education focus and maintain clinical practices in GMA. Deborah Blazey-Martin, MD, MPH The Pratt Diagnostic Center is a concierge model practice. Patients and their families are able to spend more time with their physician to discuss management of their chronic illnesses and health screening and prevention. Patients pay an annual fee for this service.

Our Community Practices, strategically located in both South Shore and MetroWest markets, opened in October of 2013. Comprised of internists and family medicine physicians, these practices are dedicated to providing excellent primary care to our patients in their own neighborhoods. They also host Tufts Medical Center specialists, bringing them closer to their patients.

The General Medicine Inpatient Service is a hospitalist service caring for a wide range of medical conditions. As the only non-subspecialty inpatient medical service, it serves as an important component of the resident and medical student education experience.

The Geriatrics Section offers both inpatient and outpatient geriatric rotations for residents, together with an educational program for nursing staff at Tufts Medical Center, and a polypharmaceutical and advanced care plan to address the special needs of elderly patients.

Long-Term Care at Kindred Boston (Boston and Stoughton Locations) is staffed by our hospitalists providing specialized, long-term acute care to medically complex patients requiring continued care and extended recovery time. The majority of patients are admitted after a stay in a short-term hospital, often from intensive care and step-down units. Highlights of 2014

»» Quincy Primary Care Practice received Patient Centered Medical Home Recognition at the highest level; added two social workers

»» Grant to initiate Point of Care testing for HbA1c

»» Added 3 new primary care physicians

»» •Entered into NEQCA Accountable Care Organization

»» Blue Cross/Blue Shield Depression Emerging measure award

»» Participated in See, Test, and Treat outreach to Chinatown Community in collaboration with Pathology andOB/GYN

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 » » Faculty CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION

Name Academic Rank Title and Special Responsibilities

Deborah Blazey-Martin, MD, Assistant Professor Chief, Internal Medicine and Adult Primary Care MPH, FACP Dineli Ahearn, MD Assistant Professor Director, Primary Care Innovation Assistant Professor, Yee Chuan Ang, MD Geriatrician John Barravecchio, MD Assistant Professor Tufts Medical Center Primary Care, Quincy Michael Cantor, MD Assistant Professor Chief Medical Officer , New England Quality Care Alliance Jeanine Carlson, MD Associate Clinical Professor Pratt Diagnostic Center Steven Carr, MD Assistant Professor Tufts Medical Center Primary Care, Quincy Daniel Chandler, MD Assistant Professor Director of Resident Internal Medicine Education Elaine Choi, MD Assistant Professor Jaclyn Chu, MD Assistant Professor Marcie Claybon, MD Assistant Professor Brian Cohen, MD Assistant Professor Medical Director, Pratt Diagnostic Center Misha Dad, MD Assistant Professor Kimberly Dowdell, MD Assistant Professor John Doyle, MD, Assistant Professor Medical Director of Employee Health Services Medical Director, Tufts Medical Center Daniel F. Driscoll, MD Assistant Professor Primary Care, Quincy Paul Duncan, MD Assistant Professor Associate Clinical Professor Richard Dupee, MD Chief of Geriatrics, Pratt Diagnostic Center Geriatrician Erika Freebern, MD Assistant Professor Karen Freund, MD Professor Associate Director of Research Collaboration, CTSI Jenny Hong Gao, MD, PhD Assistant Professor Medical Director, Tufts Medical Center Primary Care, Renee Goetzler, MD Assistant Professor Framingham Linda Kaplan, MD Assistant Professor Director, Predictive Analytics and Comparative Effectiveness (PACE) Center, ICRHPS; David Kent, MD Professor Director, Sackler School of Graduate Biomedical Sciences, Clinical and Translational Science Program

81 Faculty (continued)

Name Academic Rank Title and Special Responsibilities

Vice-Chair for Education; Program Director, Internal Richard Kopelman, MD Professor Medicine Residency Program Diane Krause, MD, MPH Assistant Professor Joan Kross, MD, MPH Associate Clinical Professor Tufts LCO Medical Director Jae Young Lee, MD Assistant Professor Tufts Medical Center Primary Care, Framingham » »

INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION Mary Lee, MD, MS, FACP Professor Special Advisor for Education Innovation James Mahoney, MD Assistant Professor Tufts Medical Center Primary Care, Quincy Assistant Professor Associate Chief of Geriatrics Cinthya Marturano, MD Geriatrician Director of Continuing Medical Education Catherine Milch, MD Assistant Professor Yueling Guo Moran, MD Assistant Professor Tufts Medical Center Primary Care, Quincy Jana Naef, MD Assistant Professor Director of Community Primary Care Education, Tufts Erin Ney, MD Assistant Professor Medical Center Primary Care, Quincy Ann Nguyen-Traxler, MD Assistant Professor Marta Onyskiv, MD Assistant Professor Tufts Medical Center Primary Care, Quincy Judy Pinsker, MD Associate Clinical Professor Karthik Ravindran, MD Assistant Professor Tufts Medical Center Primary Care, Framingham Associate Program Director of Internal Medicine Joseph Rencic, MD Associate Professor Residency Program Associate Professor, Department of Joyce A. Sackey, MD Medicine and Department of Public Dean, Multicultural Affairs/Global Health Health and Community Medicine

Kinjalika Sathi, MD Assistant Professor Assistant Director of Resident Internal Medicine Education

Kimberly Schelling, MD Assistant Professor Chief, Institute for Clinical Research and Health Policy Harry Selker, MD Professor Studies; Pratt Diagnostic Center Staff Physician Myron Siu, MD Associate Clinical Professor Director Inpatient Services Laura K. Snydman, MD, FACP Assistant Professor Clerkship Director Steven Spector, MD Assistant Professor GMA and Pratt Diagnostic Center Caitlin Toomey, MD Assistant Professor Shirly Tozzi, MD Assistant Professor Nancy Tran, MD Assistant Professor Yana Urman, MD Assistant Professor Michael Wagner, MD Associate Professor President and CEO, Tufts Medical Center Wei Wang, MD Assistant Professor, Geriatrician Saul Weingart, MD, PhD Professor Chief Medical Officer, Tufts Medical Center Elisabeth Wilder, MD Assistant Professor John B. Wong, MD Professor Chief, Clinical Decision Making, Informatics and Telemedicine Irina Zilberman, MD Assistant Professor

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Major Clinical Programs The Division of Internal Medicine and Adult Primary Care continues to increase its primary care services at Tufts Medical Center. In addition to General Medical Associates (GMA), the division has expanded services in Geriatrics, inpatient medicine and collaborative programs and has extended its services into the community in the spirit of the distributed academic medical center model.

General Medical Associates (GMA) is the largest ambulatory practice at Tufts Medical Center, located in the Biewend building. In late 2013 GMA expanded to fill a fifth team and hired 5 new full time physicians whose additional training includes Nutrition, Geriatrics, and research. Since then 3 additional doctors have joined the practice, including a » geriatrician. GMA cares for more than 34,000 patients resulting in nearly 70,000 primary care office visits per year. The » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION division also coordinates care and is a major source of referrals to subspecialty colleagues and services within the organization. GMA consists of about 40 internists, some with careers primarily devoted to clinical care or a combination of that with medical education and administration. Others have primary appointments in other divisions, mainly research institutes, but practice clinical medicine in GMA.

GMA is also the educational site for 72 internal medicine residents' continuity clinics and their training is provided by GMA preceptors. Drs. Daniel Chandler (Director of Resident Education) and Kinjalika Sathi (Assistant Director of Resident Education) coordinate their various clinical, didactic, and administrative responsibilities with a goal to best maximize their primary care education and experience. GMA has achieved the highest level of NECQA Patient Centered Medical Home (PCMH) recognition, Level 3 with Distinction, which is uncommon in academic medical centers. Population based medicine with the patient at the center is the rationale behind this model of care, and promotes the importance of team-based management of patients. The ability to leverage information technology to achieve these goals was accomplished by the addition of our Data and Project Manager, Joe Gillis to the administrative leadership team. Care teams, composed of physicians, nurse practitioners, RNs, medical assistants and practice coordinators care for all patients in the panel; outreach is facilitated by registries, information technology, health information exchange and other means to assure that patients receive the indicated care in a culturally and linguistically appropriate manner. This robust team structure has been developed and rolled out across most of the practice, resulting in increased MHQP patient satisfaction scores.

The Division's vision for PCMH transformation has the following goals:

»» Emphasize high-quality, team-based preventive care and disease management, with care coordination across the health care continuum.

»» Invite patients to actively engage in improving their health and well-being.

»» Promote physician, nurse, and staff satisfaction by redesigning the staffing model to allow everyone to work to the top of their license.

»» Commit to delivering superior customer service.

»» Create and maintain an environment where trainees learn to provide primary care at the highest level and enjoy the practice of medicine and caring for their patients.

»» Establish a data-driven practice culture of continuous improvement in the quality of care provided and the safety of the environment of care based on transparency and accountability.

GMA has added more multidisciplinary services over the past years, embedding new specialties and creating new collaborations. Dr. Lisa Ceglia from Endocrinology provides intensive diabetes consultation, management, and education within the practice. Andrea Nardini, LICSW and Amanda Weintraub, MSW provide social work services in GMA, and additional behavioral services are coordinated by Dr. David Adler from Psychiatry. Dr. Ceglia and our social workers are instrumental in collaborating to lead the team to create and deliver an innovative new Diabetes Education program for the most complicated and challenging diabetic patients. In 2014 we initiated a collaboration with the Weight and Wellness Center called "Jumpstart to Wellness," an innovative program to overcome the barriers to obesity counseling in the primary care setting allowing physicians to fast track their obese patients to the dieticians in the Weight and Wellness Center without a mandatory entry into the bariatric surgery referral.

83 As the outpatient practice site for 72 Tufts Internal Medicine Residents, the Division has made significant changes and innovations over the past year. Under the leadership of Dr. Daniel Chandler, our Director of Residency Education, we have moved to a "3+1" model for our intern class to increase their primary care continuity. Interns now spend 3 weeks learning inpatient medicine followed by 1 week of ambulatory care. This allows concentrated times where they are in clinic and are not interrupted by inpatient demands and can focus on their outpatient responsibilities. In addition, our senior residents now rotate through our Tufts Medical Center Primary Care-Quincy practice and are exposed to both a community practice and nursing home care. Dr. Chandler has also added video observations for all residents, a mandatory quality chart review project, and has created a novel pre-clinic conference structure which uses a smartphone-based audience response system and stresses feedback on public speaking and teaching skills from the preceptor to the presenting resident. » » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION The GMA Anticoagulation Service continues to monitor patients on warfarin and enoxaparin, and the novel oral anticoagulants. The service is primarily managed by nurses in consultation with a pharmacist and the primary care physicians. Patients can have blood drawn in a variety of sites convenient for them including point of care testing in GMA. In 2014 the service managed over 500 patients with excellent results in terms of compliance and time in the therapeutic range.

The general medicine inpatient service continues to be an important clinical and educational program. Under the direction of Dr. Myron Siu, Director of Inpatient Services, the general medicine ward rotation provides house staff the opportunity to have intensive exposure to patients with complex illnesses under the care of general internists and to see these physicians as potential role models for a career in general internal medicine. Dr. Siu is also in charge of the combined inpatient Geriatric Service and Medical Consultation service, which was added in 2011 to enhance the care of geriatric patients. The additional service offers geriatric training, promotes education, and offers consultation to other inpatient services.

The community practices in Framingham and Quincy are dedicated primarily to clinical care. From disease prevention to managing chronic illness to an urgent care appointment, these teams are focused on delivering high-quality, efficient care to their patients in their local communities. Both Quincy and Framingham are in newly constructed spaces, which were thoughtfully designed for optimal patient care. Each practice offers same-day appointments, onsite blood drawing stations and centralized digital medical records that can connect patients to their entire healthcare team, at Tufts Medical Center or MetroWest Medical Center.

In Quincy, Tufts Medical Center specialists rotate through the practice on a monthly basis making their services conveniently available to patients locally. Cardiologists and Dermatologists team with their Primary Care Physician colleagues to provide comprehensive, coordinated care to patients in a patient-friendly environment.

The Pratt Diagnostic Center uses a concierge model to provide a high level of service coupled with expert diagnostic care. Under the direction of Dr. Brian Cohen, the program continues to thrive since its inception ten years ago. This year we have added our Geriatric Section Chief, Dr. Richard Dupee, to the PDC where he brings his expertise in caring for the elderly. The Pratt Diagnostic Center markets its services and clinical practice to members of the Boston business community.

Teaching Activities The educational programs of the division consist of the following:

»» Residents’ Ambulatory Medicine in GMA »» Continuity Clinic »» Ambulatory Block Rotations »» Geriatric Block Rotation »» Primary Care Elective »» General Medicine Inpatient Service (staffed by a GMA attending and composed of a 3rd year resident, 2 interns, a pharmacist, and medical students). »» Third Year Medicine Clerkship for Tufts University School of Medicine »» General Medicine Consultation Service (staffed by a GMA attending and composed of a 3rd year resident, internal medicine intern, and a psychiatry intern intermittently) »» Geriatrics Inpatient Service (staffed by a GMA attending and composed of a 3rd year resident, an internal medicine intern, a psychiatry intern intermittently, and medical students)

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» Third Year Medicine Clerkship for Tufts University School of Medicine »» Fourth-year medicine sub-internships for Tufts University School of Medicine

Many of the faculty play pivotal roles in the educational programs, both for the medical school and for the residency training program. Dr. Richard Kopelman is the Program Director for the internal medicine residency training program at Tufts Medical Center. Each year, the program recruits 25 new interns and has a total of 72 residents and three chief medical residents. Dr. Joseph Rencic is the Associate Program Director of the internal medicine residency, with an additional research focus in clinical decision making and development of expertise. Dr. Laura Snydman provides oversight for the medical students during their third and fourth year medicine clerkships at Tufts Medical Center. Dr.

Daniel Chandler is Director of Resident Education for Internal Medicine and Adult Primary Care. He sets the overall » » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION education agenda for 72 residents that rotate through GMA for their continuity and primary care experience throughout their 3 years of training. Dr. Kinjalika Sathi, as the Assistant Director of Residency Education, administers the outpatient ambulatory curriculum through the primary care clinic, General Medical Associates, and associated outpatient ambulatory elective clinics. Drs. Laura Snydman, Dan Chandler, Kinjalika Sathi, Caitlin Toomey, and Joe Rencic provide a “Resident-as-Teacher” program to enhance the skills of residents in teaching medical students. The faculty of the division are recognized by medical students and residents for their excellence in teaching and their fundamental contributions to the educational programs of the medical school and medical center.

Research Activities Adult Internal Medicine is an important source of patients for clinical research trials at the medical center. With more than 34,000 patients in the practice and an electronic medical record which enables researchers to identify patients with specific diagnoses, the Division is able to work collaboratively with institutionally-sponsored research projects on identifying patients for research projects.

Honors and Awards

Dineli Ahearn, MD Awards »» Top Doctor 2014, Boston Magazine

Deborah Blazey-Martin, MD MPH Awards »» President’s Council of Cornell Women, elected 2014 Committee Assignments »» NEQCA Board of Trustees »» Trustee, NEQCA Accountable Care Invited talks »» “Jumpstart to Wellness Pilot Program: A collaborative approach to managing morbid obesity” Deborah Blazey-Martin, MD, MPH; Michael Tarnoff, MD, Jillian Regan, RD; Melissa Page, RD. NEQCA Fall Forum. Norwood, MA. 10/1/2014.

Michael Cantor, MD JD Committee Assignments »» Chair, Physician Council of the Massachusetts Health Quality Partners (MHQP) – the statewide quality measurement collaborative. »» Vice Chair, Board of Trustees, MHQP. »» Member, Medical-Scientific Advisory Committee, Mass-New Hampshire Chapter, Alzheimer’s Association »» Member, Massachusetts Registry of Motor Vehicles, Medical Advisory Board

Daniel Chandler, MD Awards »» Excellence in Teaching Award, Tufts Medical School

85 Kimberly Dowdell, MD Awards »» Julius 'Red' Kritzman Award for Primary Care Teaching

Daniel Driscoll, MD Committee Assignments »» NEQCA Board of Trustees

Karen Freund, MD MPH » » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION Awards and Honors »» Freund KM, Raj A, Terrin N, Kaplan S, Urech T, Carr PL. Progress or Stalemate in Academic Gender Disparities? 15 Year Follow up of the National Faculty Survey. J Gen Intern Med. 2014:29(1 Suppl):S191. Awarded Best Oral Abstract in Women’s Health, National SGIM meeting, 2014. Committee Assignments »» Agency for Healthcare Research and Quality (AHRQ), Health Care Research Training (HCRT) Study Section »» Editor, Editorial Board, Cancer Epidemiology, Biomarkers and Prevention Invited talks »» Progress or Stalemate in Academic Gender Disparities? 15 Year Follow up of the National Faculty Survey. National SGIM Meeting, San Diego CA, April 18, 2014

Jenny Gao, MD PhD Awards »» Notable Teaching Award, Tufts Medical School

David Kent, MD Professional Society Committee Assignments and Leadership »» Invited Abstract Reviewer, Health Services, Quality Improvement, and Patient-Centered Outcomes Category, International Stroke Conference 2015 »» Comparative Effectiveness Research, Methods Committee, Society of Clinical and Translational Science

National Panels »» Ad Hoc Member, National Institute of Neurological Disorders and Stroke Special Emphasis Panel, National Institute of Neurological Disorders and Stroke PD Planning Grant Review, December 10, 2014 (ZNS1 SRB-J-08) »» Scientific Advisory Board, Ware Working Group on Neurodegenerative Disease Ethics and Policy, University of Pennsylvania »» External Advisor, Patient Centered Outcomes Research Institute (PCORI) Methodology Committee Workgroup on Heterogeneity of Treatment Effect

Invited Lectures & Presentations »» “Why Risk Based Subgroup Analysis Should be Routine.” Society for Clinical Trials (SCT) 35th Annual Meeting. Philadelphia, PA, USA. May 18-21, 2014. »» “Variation in individual treatment effects from repeated period cross-over and multi-person N-of-1 studies.” International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 19th Annual International Meeting. May 34 – June 4, 2014. Montreal, Canada. »» “Using Group Data to Treat Individuals: Understanding the Importance of Heterogeneity of Treatment Effects for Clinical Decision- Making.” Tufts CTSI Heterogeneity of Treatment Effects in Clinical Trials Seminar: Lahey Clinic. Burlington, MA. June 4, 2014. »» “Assessing and Reporting Heterogeneity of Treatment Effect in Clinical Trials,” NIH Collaboratory Webinar Grand Rounds, September 12, 2014 Video: https://www.nihcollaboratory.org/Pages/Grand-Rounds-Hub.aspx

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» “Treatment Effect Heterogeneity in Clinical Trials: “An evaluation of 13 large clinical trials using individual patient data.” International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual European Congress. November 8-12, 2014. Amsterdam RAI in Amsterdam, The Netherlands. (poster) »» “Risk modeling and heterogeneity of treatment effect.” International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual European Congress. November 8-12, 2014. Amsterdam RAI in Amsterdam, The Netherlands. (workshop)

Richard Kopelman, MD Awards »» Accomplished Teaching Award, Tufts Medical School » » »» Career Mentorship Award—Spotlight Series on Mentorship—Association of Program Directors in Internal Medicine (ADPIM ) CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION »» Publications: Vedula R, Kopelman R, Rencic J. Complementary medicine. J Gen Intern Med. 2014;29:412-416.(Clinical reasoning series)

Joan Kross, MD MPH »» Annual LCO Medical Director Leadership Award—Adult Practice

Mary Y Lee, MD »» Special Advisor for Education Innovation, TMC »» TMC Board of Governors, member »» TMC Board of Governors, Quality of Care Committee, member »» Completed 12 years as Associate Provost, Tufts University Awards and national/international talks »» 2014 Tufts University, Distinguished Service Award »» 2014 Selected as the 2014-2015 International Kimitaka Kaga Visiting Professor, Graduate School of Medicine, The University of Tokyo (6-month full-time faculty position); provided monthly medical education seminars simulcasted to all major universities in Japan; assisted The University of Tokyo with their first national medical school accreditation; conducted clinical teaching of residents and medical students; invited as keynote to several other universities across Japan »» 2014 Invited Keynote: “Leading Institutional Change: Pearls from Implementing a Flipped Curriculum at Tufts University,” University of Nebraska Medical Center, Omaha, Nebraska, March 2014 »» 2014 Invited Keynote: “Disruptive Technologies in Education: Maximizing Impact,” Harvard Macy Institute, Boston, MA, June 2014 »» 2014 “Flipping the Curriculum: A Toolkit to Prepare Your Institution for Success” HY Liu, RW Rockhold, LH Fall, MY Lee, LM Love, TA Birk; AAMC Group on Faculty Affairs (GFA) Professional Development Conference, Boston, MA, July 2014 »» 2014 Invited Keynote: “Flipping an Entire Curriculum, Piece by Piece,” Faculty Scholarship Exchange Seminar Series, University of Mississippi Medical Center, Jackson, Mississippi, August 2014 »» 2014 Invited Keynote: Curriculum Reform and Accreditation in Medical Education: Lessons from Tufts University, Kyoto University, November 2014 »» 2014, Board Member, OpenCourseWare Consortium (global consortium, stepped down at end of January 2014) Grants »» Aug 2014-Jul 2017 “Capacity Building for Medical Education in Bioethics in India,” Obama-Singh 21st Century Knowledge Initiative, United States-India Educational Foundation (USIEF/Fulbright), Tufts University School of Medicine and Christian Medical College, Vellore, India. PIs: Aviva Must (Tufts), Ansu Pulimood (CMC); MY Lee, OSI faculty for faculty development training »» Nov 2014-Nov 2019 “One Health Work Force,” USAID No: P004721401. $ 8,598,962 subaward to Tufts University; Deputy Director: Saul Tzipori, Cummings School of Veterinary Medicine; MYLee, expert consultant for faculty development, leadership training, curriculum development, open educational resources, online learning

87 Joseph Rencic, MD Awards »» Accomplished Teaching Award, Tufts Medical School

Joyce Sackey, MD »» Member, President’s Council on Diversity »» Chair, Group on Graduate and Professional Students’

Kinjalika Sathi, MD » » INTERNAL MEDICINE AND ADULT PRIMARY CARE ADULT PRIMARY AND MEDICINE INTERNAL OF DIVISION Awards »» Notable Teaching Award, Tufts Medical School

Harry Selker, MD, MSPH National Panels: »» Agency for Healthcare Research and Quality, National Advisory Council Member »» National Institutes of Health: Directors Pioneer Award Review Committee Professional Society Committee Assignments and Leadership: »» Society for General Internal Medicine Conflict of Interest Committee »» Association for Clinical and Translational Science, Board of Directors, Vice President for Healthcare Implementation, »» Delivery, and Policy Research, Chair, Public Policy Committee »» Clinical Research Forum: Public Policy Committee Chair »» Health Resources in Action: Board of Directors »» Association for Clinical Research Training: Chair, Advocacy Committee Editorships: »» Journal of Investigative Medicine, Associate Editor »» Clinical and Translational Science, Executive Editor

Laura K. Snydman, MD Awards »» 2014 Recognized as a Compassionate Caregiver (part of the Schwartz Center’s Honor Your Caregiver tradition) Committee Assignments: »» Elected to Fellowship in the American College of Physicians »» President, Regional Leadership Board, Society of General Internal Medicine, New England Region »» Member, Board of Regional Leaders, Society of General Internal Medicine Undergraduate Medical Education: »» 2013-present Internal Medicine Site Clerkship Director, Tufts Medical Center »» 2013-present Learning Community Advisor, TUSM (first and second year medical students)

Saul Weingart, MD, PhD Awards and Recognition: »» Promoted to Professor of Medicine at TUSM »» Promoted to Fellow of ACP »» Gave Grand Rounds at Tufts MC in anesthesia and pediatrics, »» Gave Grand Rounds for the 10th Annual Rafael Miara Patient Safety Lecture at Boston Medical Center Committee Assignments: »» Completed term as Chair of the Board of Governors of the National Patient Safety Foundation »» Board Member, NPSF Board of Directors »» Member, Advisory Board of the Betsy Lehman Center for Patient Safety and Medical Error Reduction

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 John Wong, MD, FACP »» Co-chair, American Medical Association/American Gastroenterological Association/Association for the Study of Liver Disease, Physician Consortium for Performance Improvement. Work Group on Hepatitis C »» Committee Member, Institute of Medicine (IOM), Diagnostic Error in Health Care »» Systematic Review Member, American Association for the Study of Liver Disease (AASLD), Hepatitis B Guidelines »» Discussion Leader, Patient-Centered Outcomes Research Institute, Hepatitis C Workshop (Screening and Diagnostic Tests) »» Chair, Awards Committee, Society for Medical Decision Making

89 ADULT PRIMARY CARE— GERIATRICS

The Geriatrics section of the Division of Internal Medicine and Adult Primary Care was established in » » GERIATRICS CARE ADULT PRIMARY the spring of 1998 in order to enhance the training of students and residents in the subspecialty of geriatrics. Residents and students receive formal instruction and are assigned clinical experience in geriatric medicine. Tufts Medical Center provides comprehensive geriatric assessment.

The Geriatrics section welcomed Dr. Richard Dupee to the Pratt Diagnostic Center at Tufts Richard Dupee, MD Medical Center in 2014. The section has also recently added another geriatrician, Dr. Yee Chuan Ang, a Palliative Care physician, will be joining the division shortly and will have a substantial role in geriatrics care. Geriatrics also plays instrumental role in the NEQCA ACO (Accountable Care Organization) that General Medical Associates joined in 2014.

Faculty

Name Academic Rank Title and Special Responsibility Richard Dupee, MD Associate Clinical Professor Chief of Geriatrics Yee Chuan Ang, MD Assistant Professor Geriatrician Chief Medical Officer, New England Quality Michael Cantor, MD Assistant Professor Care Alliance Cinthya Marturano, MD Assistant Professor Associate Chief of Geriatrics Wei Wang, MD Assistant Professor Geriatrician

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Major Clinical Programs Geriatrics Inpatient Service Older persons are at disproportionate risk of becoming seriously ill and requiring hospital care. The utilization of acute hospital care by older persons is increasing rapidly with the aging of the population.

Once hospitalized, older patients are at high risk for loss of independence and institutionalization.

The inpatient geriatrics service at Tufts Medical Center, comprising a resident team, and led by a geriatrician, is designed to prevent loss of function and other serious events and conditions common to this age group following

hospitalization. » » GERIATRICS CARE ADULT PRIMARY Geriatrics Consultation Service The resident team, led by a geriatrician, is available to all medical and surgical services for inpatient consultation regarding issues and complications that frequently occur when an older patient is hospitalized, guiding the various subspecialty services In their care of these patients.

MedWest Center for Memory Disorders and Conditions of Older Adults The MedWest Center for Memory Disorders and Conditions of Older Adults was established in conjunction with Tufts Medical Center. A team of specialists identifies and treats patients with mild cognitive impairment and with various stages of Alzheimer’s disease. Specific and sensitive evaluation tools are used to provide early and accurate diagnosis and treatment, and this approach has given substantial support to patients and families.

Teaching Programs The Geriatrics Service is engaged in the teaching of Tufts University medical students and internal medicine residents. For students at Tufts University School of Medicine, exposure to geriatrics may begin as early as in the first year. Each year a first-year student with an interest in geriatrics spends one-half day a week in Dr. Dupee’s Wellesley office. The elective is consistently rated highly by student evaluations.

Third-year clerkship students doing electives in medicine attend conferences on geriatric conditions during each block at Tufts Medical Center.

Internal medicine residents at Tufts Medical Center are exposed to case-based noon conferences relating to geriatric conditions. The sessions are highly interactive. In addition, second-year residents have the opportunity to see patients with Dr. Dupee in his Wellesley office. This format allows residents to have exposure to longitudinal care of the elderly. The program has been popular with residents, some of whom have chosen second and even third sessions.

Honors and Awards

Richard Dupee, MD »» Voted “Top Doctors in Geriatrics” Boston Magazine »» “Top Doctors in Geriatrics” Castle-Connolly National Professional Society Committee Appointments »» Governor, American College of Physicians, Massachusetts Chapter (2010-2014) »» President, Massachusetts Geriatrics Society (2009-2014) »» Member, Health and Public Policy Committee, American College of Physicians (2012-2014) »» Member, Editorial board, “Annals of Long-term Care” (2003-present) »» Member, Geriatric Task Force Committee. Tufts University School of Medicine & Bay State Medical Center.

91 WILLIAM B. SCHWARTZ DIVISION OF NEPHROLOGY

The William B. Schwartz Division of Nephrology is internationally known for the quality of patient care, » » NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM teaching, research, and public policy contributions. In the early years of the Division, William B. Schwartz and his colleagues elucidated many basic principles of acid-base and fluid and electrolyte homeostasis which are used to this day. In recent years, the Division has carried out seminal studies in the epidemiology, progression, and treatments of chronic kidney disease and the effects of chronic kidney disease on cardiovascular disease. Members of the Division have led the development and implementation Andrew Levey, MD of clinical guidelines for the identification, classification, and treatment of kidney diseases. In its research and its clinical programs, the Division has emphasized collaboration with other specialties (metabolism, neurology, cardiology, infectious disease, urology, and transplantation surgery) and disciplines (epidemiology, statistics).

The Division has established multidisciplinary clinics for polycystic kidney disease and kidney transplantation. The home dialysis program is growing rapidly.

The teaching programs emphasize basic science-clinical correlations. Fellowships are available in clinical nephrology and in research. Participants in the research fellowship program undertake formal training in research methods culminating in a Master of Science degree at the Sackler School of Graduate Biomedical Sciences at Tufts University.

Division members collaborate with methods experts to use the research approaches appropriate for epidemiology, clinical trials, development of clinical practice guidelines, and outcomes. They also collaborate with domain experts to focus on the research areas of: chronic kidney disease, assessment of kidney function, aging, nutrition, dialysis and transplantation, progression, polycystic kidney disease, acute kidney injury, and hypertension. Basic science studies involve the role of inflammation and oxidative stress in chronic kidney disease and the role of immunosuppressive regimens in predisposing to infections in dialysis and transplant patients.

Tufts Medical Center is the site of the editorial offices of the American Journal of Kidney Diseases (AJKD), the official journal of the National Kidney Foundation. The Editor, Deputy Editor, and other Editors are members of the Division. Highlights of 2014

»» Dr. Levey was recognized by Thomson Reuters as a highly influential researcher.

»» Dr. Meyer received the Distinguished Faculty Award from Tufts University School of Medicine.

»» Dr. Perrone was the PKD Foundation’s Physician of the Year and the recipient of the National Kidney Foundation’s Donald W. Seldin Distinguished Award recognizing clinical excellence.

»» Drs. Perrone and Miskulin were authors of New England Journal of Medicine articles on the results of the HALT-PKD Study.

»» Dr. Sarnak delivered the Shaul G. Massry Distinguished Lecture at the National Kidney Foundation Spring Clinical Meeting.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibility » »

Division Chief NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM Andrew S. Levey, MD Professor Editor of the American Journal of Kidney Diseases Associate Division Chief Ronald D. Perrone, MD Professor Director, Polycystic Kidney Disease Center Medical Director, Kidney Transplantation Michael B. Cohen, MD Assistant Professor Co-Medical Director, DCI Ball Square Anthony Z. Dash, MD Assistant Professor Co-Medical Director, DCI Ball Square Meredith C. Foster, ScD, MPH Research Assistant Professor Scott J. Gilbert, MD Associate Professor Director, Fellowship Training Program Director, Quality Improvement Lesley A. Inker, MD, MS Associate Professor Medical Director, Kidney and Blood Pressure Center Vice Chairman of Medicine for Clinical Affairs, St. Elizabeth’s Bertrand L. Jaber, MD, MS Associate Professor Medical Center Alin A. Joseph, MD, MS* Clinical Instructor Amy B. Kuhlik, MD Assistant Professor Dean for Student Affairs, TUSM Maurice S. Segal, MD Nicolaos E. Madias, MD Chairman of Medicine, St. Elizabeth’s Medical Center Professor of Medicine Director, Dialysis Services Tufts Medical Center Medical Director, DCI BostonMedical Director, Home Dialysis Klemens B. Meyer, MD Professor Program at DCI Ball Square Medical Director, DCI Information Systems Dana C. Miskulin, MD, MS Associate Professor Madhumathi Rao, MD, PhD Assistant Professor Medical Director, DCI Walden Pond Director, DCI Outcomes Monitoring Program Michelle M. Richardson, PharmD Assistant Professor Director of Communications Director of Research Mark J. Sarnak, MD, MS Professor Associate Director, Research Training Program in Nephrology Associate Medical Director, DCI Boston Daniel E. Weiner, MD, MS Assistant Professor Deputy Editor, American Journal of Kidney Diseases

*New appointment in 2014 Major Clinical Programs Kidney and Blood Pressure Center (KBPC) Outpatient clinical activities take place primarily in the Center, directed by Dr. Inker. The Center emphasizes a multi- disciplinary approach to kidney disease in collaboration with the Division of Transplant Surgery, Department of Urology, the DCI outpatient dialysis unit and the Frances Stern Nutrition Center. The KBPC specializes in the diagnosis and management of CKD, hypertension, glomerular diseases, kidney transplantation, and peritoneal dialysis. In 2013, the KBPC began outpatient measurements of GFR.

93 The Center carries out clinical studies on chronic kidney disease (CKD), including studies of polycystic kidney disease, lupus nephritis (in conjunction with the Division of Rheumatology), immunosuppression for transplantation, cardiovascular disease in transplantation, computerized quality of life assessment, and genetic predisposition to progression.

Home Dialysis The Division has an active home dialysis program at DCI’s Ball Square facility in Somerville, comprising both peritoneal dialysis and home hemodialysis. Patients are eligible if they are able to perform the required tasks, do not live alone and have insurance adequate to cover the procedures. Because of its convenience, the program is much appreciated by patients.

» Center for Polycystic Kidney Disease » NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM The Center for Polycystic Kidney Disease at Tufts Medical Center was opened in 2006. The physicians are internationally recognized experts in treating and managing the complications of PKD. On average, 50 new patients are seen each year in this program. Areas of expertise for patients with PKD include dialysis and transplantation and the evaluation and management of the complications of liver and kidney cysts including chronic pain, kidney stones, and cardiovascular issues such as intracranial aneurysms. Care is coordinated with the Departments of Urology, Neurosurgery, Transplantation Surgery and Genetics.

Kidney Transplantation Program A weekly Transplant Multidisciplinary clinic is staffed by Dr. Perrone, Medical Director of Kidney Transplantation, together with a transplantation surgeon. Nurse practitioners serve as transplantation coordinators. The multidisciplinary nature of the team facilitates consultations for patients who have already received transplants, as well as for patients and donors for whom transplantation is being considered. Another benefit of this joint activity is the facilitation of dialysis access planning and interventions.

In-center Dialysis The DCI Boston in-center hemodialysis unit located at Tufts operates 21 stations. There are two affiliated in-center dialysis clinics, one at Ball Square in Somerville, the other at Walden Pond in Concord, MA. Both programs are routinely recognized for high quality clinical care.

Inpatient Programs The Division provides routine consultation in the diagnosis and management of kidney diseases, as well as expertise for all forms of renal replacement therapy including hemodialysis, peritoneal dialysis, continuous renal replacement therapy, and charcoal hemoperfusion.

Under the direction of Dr. Perrone, the Division participates in the Tufts Medical Center Kidney Transplant Program. Many of the donors in this program are living donors. Tufts Medical Center is a member of the New England Program for Kidney Exchange (NEPKE) that coordinates sharing by mismatched donor-recipient pairs. Patients who have received transplants are followed in the KBPC. The transplant team at Tufts Medical Center has carried out more than 1230 kidney transplants.

Inpatient Dialysis Dialysis Clinic, Inc., the hospital’s dialysis provider, performs pediatric as well as adult hemodialysis at Tufts Medical Center, with Dr. Meyer as director. Because patients receiving hemodialysis treatment usually are also undergoing many other tightly scheduled tests and procedures, the program is organized so as to enhance patient flow. Continuous venovenous hemofiltration (CVVH) and slow continuous ultrafiltration (SCUF) are also available.

Inpatient peritoneal dialysis is performed in intensive care units and on the North 7 inpatient ward, where the nursing staff are trained to perform peritoneal dialysis. Tufts Medical Center is the only hospital in Greater Boston with a floor on which the staff nurses are trained to perform peritoneal dialysis.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Teaching Activities The Division of Nephrology is committed to education at the national as well as the local level. Division members carry out clinical and basic research, serve on national boards that establish standards in clinical practice, and lecture at local, national, and international conferences.

Division members participate extensively in the preclinical years (renal pathophysiology, physical diagnosis) and the clinical years (ward and consultation services) of the medical school. Dr. Gilbert conducts a series of lectures on core nephrology topics for 3rd year students during their internal medicine clerkships at Tufts Medical Center. In addition, Dr. Gilbert offers an elective in evidence-based medicine to 4th year students. » » Interns and residents at Tufts Medical Center rotate through the renal ward service and may choose an elective on the NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM renal consultation service. Senior residents may also choose an elective in the Kidney and Blood Pressure Center. The senior residents routinely rank this outpatient experience highly.

The Division participates in other postgraduate forums. Several Division members serve as research mentors to Masters of Science candidates in the Sackler School of Graduate Biomedical Sciences. Dr. Gilbert coordinates nephrology lectures in the Advanced Molecular and Cellular Pharmacology Course at Tufts University School of Medicine, teaches Renal Pharmacology at the Sackler School of Graduate Biomedical Sciences and leads the Renal Section of the Nutritional Biochemistry and Physiology at the Friedman School of Nutrition Science and Policy.

Clinical Fellowship Training Under the direction of Dr. Gilbert, the clinical fellowship program offers training of unusual breadth and depth. Fellows have clinical rotations both at Tufts Medical Center and at St. Elizabeth’s Hospital. Over the past 14 years, almost half of the 33 graduates of the fellowship program have continued in full-time academic positions. Another quarter have become private practitioners with substantial teaching responsibilities, typically in hospitals with university affiliations. The remainder are engaged in private practice.

Research Fellowship Training The William B. Schwartz Division of Nephrology offers clinical research training through the NIDDK Institutional Research Training Award in “Epidemiology, Clinical Trials and Outcomes Research in Nephrology”. This award funds three research trainees per year. The program is designed for fellows aspiring to a career as an independent investigator in clinical research in nephrology. The program has been focused primarily on chronic kidney disease, but in recent years, there has been a growing interest in acute kidney injury.

Policy Initiatives Chronic Kidney Disease in Nicaragua Dr. Weiner collaborates with public health researchers from Boston University School of Public Health to investigate chronic kidney disease among workers in rural Nicaragua. The objective is to explore the reported high prevalence of kidney disease among working age residents in rural northwest Nicaragua to better define prevalence and to develop hypotheses regarding cause.

DCI Information Systems and Outcomes Monitoring Programs Dr. Meyer is Medical Director for Information Systems for Dialysis Clinic, Inc., and is a principal architect of DCI’s information system, which sets an industry standard for quality of care and of information. The team’s current projects include continued development of decision support tools for treatment of anemia in dialysis patients and the implementation of an interface between hemodialysis machines and the information system. Dr. Richardson directs the corporate-wide DCI Outcomes Monitoring Program, which uses patient experience data to improve care.

National Kidney Disease Education Program Dr. Inker is a member of the National Kidney Disease Education Program (NKDEP) of the NIDDK. She has participated in the efforts of the NKDEP to recommend reporting GFR estimates by clinical laboratories and to standardize serum creatinine assays for more accurate GFR estimation.

95 Research Activity Research in the Division of Nephrology is focused on solving clinical problems. Each research project has domain experts, generally a nephrologist, a methods expert, and collaborators from other disciplines. Although the primary emphasis has been on chronic kidney disease, there are a growing number of projects in acute kidney injury. Some of the areas of recent emphasis are: chronic kidney disease, assessment of kidney function, aging, nutrition, dialysis and transplantation, progression, polycystic kidney disease, acute kidney injury, and hypertension.

In 2013, two William B. Schwartz Division of Nephrology members held Career Development (K23) Awards and one Division member held a prestigious Midcareer Investigator Award in Patient Oriented Research (K24). » » NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM Clinical Research Activity

Recipient Funding Source Purpose of Award Using folic acid for to reduce vascular outcomes in patients NIH/RI Hospital with kidney (FAVORIT) Assess aorta, brain, and kidney structure and function in the NIH/NIDDK AGES-Reykjavik study (with Dr. Inker) Seek markers for CKD in a representative multi-ethnic NIH/NIDDK population with measured GFR (with Dr. Inker)

Andrew S. Levey, MD National Kidney Foundation Assess GFR Decline as an Outcome for Clinical Trials in CKD

NIH/NIDDK Estimating GFR from a Panel of Endogenous Filtration Markers

Monitoring PD adequacy using serum levels of endogenous DCI filtration markers

NIH* Chronic Kidney Disease Prognosis Consortium

Lesley A. Inker, MD, MS Pharmalink Proteinuria Reduction/Primary IGA Nephropathy Patients NIH/NIDDK Blood Pressure in Dialysis Assessing the accuracies of an autoregulatory adequacy measure derived from the pulse oximeter pulse waveform DCI and of the Crit-Line device to predict fluid removal induced Dana C. Miskulin, MD, MS hypotensive events during hemodialysis.s NIH Pragmatic trials in maintenance hemodialysis DCI Decision support for anemia management in HD Intelomed* Measuring cardiovascular stress in hemodialysis patients A multi-center, longitudinal observational study of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) Otsuka to establish the characteristics and determinants of disease progression. Determine long-term safety and efficacy of oral tolvaptan in Otsuka adults with ADPKD Investigate modified-release (MR) and immediate-release (IR) Ronald D. Perrone, MD Otsuka Tolvaptan in subjects with Autosomal Dominant Polycystic kidney disease (ADPKD) NIH/NIDDK PKD Clinical Trials Network Compare the efficacy and safety of Tolvaptan in patients with Otsuka* ADPKD and CKD Stages 2-4 Evaluate the long-term safety of titrated immediate-release Otsuka* Tolvaptan in patients with ADPKD

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Recipient Funding Source Purpose of Award Gastrointestinal microbiota, systemic infection, and Madhumathi Rao, MD, PhD DCI inflammation in dialysis patients NIH/NIDDK Investigate cognitive function in hemodialysis patients Assess relationship among chronic kidney disease, vascular NIH/NIDDK disease and aging Mark J. Sarnak, MD, MS The Aging Kidney: Chronic Injury, Impaired Functions and NIH Clinical Outcomes »

Kidney tubular damage and dysfunction identify a novel axis of » NIH* NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM kidney disease DCI Safety and effects of supplementation with ergocalciferol Analysis of pulse wave velocity and central aortic pressure NIH outcomes in SPRINT Randomized trial of exercise training on cognitive and physical NIH/NIDDK functioning in CKD Assess safety and efficacy of ferric citrate in patients on Keryx dialysis Daniel E. Weiner, MD, MS NIH SPRINT Main Phase II Renal disease, kidney cancer, and metalworking fluid exposure NIH* in autoworkers NIH* MIND and the kidneys Cardiovascular outcomes in subjects with Type 2 DM and diabetic nephropathy Janssen* Evaluate the safety and efficacy of pyridorin in subjects with nephropathy due to Type 2 DM

* New grant in 2014 Basic Research

Recipient Funding Source Purpose of Award Use a proteomic approach to CKD biomarker discovery and Andrew S. Levey, MD NIH/NIDDK validation

Honors and Awards

Andrew S. Levey, MD »» Recognized in Boston Magazine as one of Boston’s best nephrologists »» Recognized by Thomson Reuters as a highly influential researcher »» Member, NKF Scientific Advisory Board »» Invited lecture: Visiting professor at Icahn School of Medicine, NY, NY »» Invited lecture: ASN Board Review Course, Chicago, IL »» Major Grant Awards in 2014: Please see Table of Research Activities

97 Ronald D. Perrone, MD »» Recognized in Boston Magazine as one of Boston’s best nephrologists »» Recipient of the Donald W. Seldin award from the National Kidney Foundation »» Co-executive director, Polycystic Kidney Disease Outcomes Consortium »» Invited Lecture: New Directions for ADPKD, NKF Spring Clinical Meeting, Las Vegas NV »» Invited Lecture: Genetics of Non-glomerular disease. NKF Spring Clinical Meeting, Las Vegas NV »» Invited lecture: Therapeutic intervention in ADPKD: disease mechanisms and pathways to drug development. Quebec Canada »» Invited lecture: Cardiovascular complications in PKD. Federation of American Societies for Experimental Biology. Lucca, Italy » » NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM »» Invited lecture: PKD: from molecular mechanisms to therapy. Federation of American Societies for Experimental Biology. Lucca, Italy »» Major Grant Awards in 2014: Please see Table of Research Activities

Scott J. Gilbert, MD »» Member, Medical Advisory Board of the NKF of New England »» Member, Panel for Accreditation Appeals in Nephrology - Accreditation Council for Graduate Medical Education »» Member, Executive Committee of the Nephrology Training Program Directors for the American Society of Nephrology »» Outstanding Attending Teaching Award from House Staff »» Excellence Teaching Citation from TUSM Clerkship students »» Outstanding Teaching Award in the Preclinical years from Senior Class of Tufts University School of Medicine »» Ranked as a top TUSM lecturer by preclinical medical students at TUSM

Lesley A. Inker, MD, MS »» Co-chair, KDOQI Guideline Commentary Workgroup for the new KDIGO Chronic Kidney Disease Guideline Update. »» Chair, Clinical Oversight Committee of KEEP »» Member of the National Institute for Diabetes, Digestive and Kidney Disease: United States Renal Data System External Advisory Committee and Vascular Access Consortium External Advisory Committee »» Member, National Kidney Disease Education Program Laboratory Work Group. »» Invited lecture: Invited lecture:

Nicolaos E. Madias, MD »» Member, Advisory Board for the Hellenic Bioscientific Association in the USA »» Invited lecture: American College of Physicians Internal Medicine Annual Meeting, Orlando FL »» Invited lecture: 18th Panhellenic Congress of Nephrology. Alexandroupolis Greece »» Member, editorial boards of Hippokratia, Hellenic Medicine, International Angiology, Arterial Hypertension and Kidney: A current survey of world literature

Klemens B. Meyer, MD »» Recognized as a “Top Doctor” by Boston Magazine »» Received Distinguished Faculty Award from TUSM »» Member, Quality Management Committee and Medical Information Steering Committee of Dialysis Clinic Inc »» Member, Renal Disease and Detoxification Committee of the Association for the Advancement of Medical Instrumentation »» Member, American Association of Kidney Patients Medical Advisory Board »» Member, USRDS External Advisory Committee and Fistula First Breakthrough Initiative »» Invited Lecture: Invited Lecture:

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Dana C. Miskulin, MD, MS »» Member, Quality Management Committee of Dialysis Clinic Inc »» Chair, Endpoints Committee for the HALT-PKD Study »» Major Grant Awards in 2014: Please see Table of Research Activities »» Michelle M. Richardson, PharmD »» Invited lecture: Health-related quality of life – It’s not just for social workers anymore. How every member of the IDT can use HRQOL scores to impact patient care. 34th Annual Dialysis Conference Atlanta GA »» Invited lecture: Measuring and improving patient experience in dialysis. 34th Annual Dialysis Conference, Atlanta GA » » NEPHROLOGY OF DIVISION SCHWARTZ B. WILLIAM Mark J. Sarnak, MD, MS »» Recognized in Boston Magazine as one of Boston’s best nephrologists »» Recipient of the Shaul G. Massry Distinguished Lecture award from the National Kidney Foundation »» Co-chair, Cardiovascular Health Study (CHS) Renal Work Group »» Co-chair, KDIGO Clinical Practice Guideline for Lipid Management in CKD »» Member, Steering Committee for CKD Prognosis Consortium »» Invited lecture: Renal Rounds New York University, NY NY »» Invited lecture: Hypertension in older CKD patients. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Visiting professor Drexel University College of Medicine Hahnemann University Hospital »» Excellence Teaching Citation from TUSM Clerkship students »» Major Grant Awards in 2014: Please see Table of Research Activities

Daniel E. Weiner, MD, MS »» Chair, ASN Quality Metrics Task Force »» Co-chair, 2015 National Kidney Foundation Spring Clinical Meeting Program Committee »» Chair designate, 2016 National Kidney Foundation Spring Clinical Meeting Program Committee »» Grant reviewer, NIA GEMSSTAR review committee »» Member, ASN Public Policy Board »» Member, DCI Medical Director Research Committee and Quality Management Committee »» Invited lecture: How to make real changes in a dialysis facility. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Eating and enteral therapy during hemodialysis. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Understanding the readmission problem in dialysis patients. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Cognitive and psychosocial disorders. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Literature review, dialysis 2013-2014. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: ESCOs and ACOs: Accountable care in nephrology. NKF Spring Clinical Meeting Las Vegas NV »» Invited lecture: Fluid management in hemodialysis: what does the future hold? ASN Renal Week Philadelphia PA »» Invited lecture: How to care for dialysis patients in a world of population quality metrics. ASN Renal Week Philadelphia PA »» Major Grant Awards in 2014: Please see Table of Research Activities

99 DIVISION OF PULMONARY, CRITICAL CARE AND SLEEP » » PULMONARY, CRITICAL CARE AND SLEEP MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION MEDICINE

The Pulmonary Division was established in 1971. During the 31-year tenure of its first chief, Dr. Fanburg, the Division grew to comprise ten active MD members and two full-time PhD members.

Dr. Fanburg established a highly regarded basic research program that focused on metabolic activities of the lungs including angiotensin converting enzyme activity as well as endothelial cell biology. His more recent studies have focused on signal transduction pathways related to Nicholas Hill, MD serotonin, its transporter and receptors, in the regulation of pulmonary vascular smooth muscle cell proliferation. Dr. Fanburg has received international recognition and numerous awards for his work.

Dr. Nicholas Hill assumed the directorship in 2002 and has expanded the clinical research activities in the division along with a doubling in the size of the faculty. Clinical trials are underway on pulmonary hypertension, high flow nasal oxygen and ventilator management of ARDS. There are also studies in progress to improve ventilator outcomes, especially through the use of noninvasive ventilation. This modality has gained wide acceptance for its ability to improve outcomes in patients with certain forms of respiratory failure.

The Division offers a wide array of clinical services. In the early 1990s, it became the Pulmonary and Critical Care Division when it assumed the medical care of patients in the Medical Intensive Care Unit at Tufts Medical Center. The Center for Sleep Medicine was incorporated in 2002 under the direction of Dr. Carolyn D’Ambrosio. In addition, specialty clinics in asthma, pulmonary hypertension, TB, lung cancer and amyotrophic lateral sclerosis are conducted by the Division. The addition of Dr. Maher Tabba in 2008 brought skills in interventional pulmonology to the Division. The Division also added coverage of two intensive care units in Lowell, Massachusetts, at Lowell General Hospital and Saints Medical Center in 2013. Dr. Greg Schumaker was appointed to direct this aspect of the Division’s activities. Highlights of 2014

»» Dr. Nicholas Hill appointed chair of the Steering Committee of the NIH-sponsored Pulmonary Vascular Diseaseomics project

»» Dr. Ioana Preston appointed Chair of the Educational Committee of the Pulmonary Hypertension Association

»» Dr. Kari Roberts serves as Associate Program Director of the Internal Medicine Residency program

»» Dr. Greg Schumaker directs the Lowell General and Saints Medical Center ICUs

»» Dr. Michael McBrine co-directs the ICU at BID-Plymouth Hospital in Plymouth, MA

»» The Division receives major NIH awards (Drs. Fanburg, Hill and Toksoz)

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibility Division Chief Nicholas Hill, MD Professor Director, Respiratory Department Director, Pulmonary Hypertension Center Christina Anderlind, MD Assistant Professor Walter Baigelman, MD Associate Professor Medical Director, Managed Care »

Associate Director, Winchester Hospital ICU » Amy Chi, MD Assistant Professor MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION Coordinator, Winchester Hospital ICU moonlighter program Carolyn D’Ambrosio, MD Associate Professor Director, The Center for Sleep Medicine Director, ICU Pharmacology Research Program John Devlin, Pharm D Adjunct Associate Professor Special and Scientific staff Scott Epstein, MD, FACP Professor Dean of Educational Affairs, TUSM Barry Fanburg, MD Professor Director, Pulmonary Research Geraldine Finlay, MD Adjunct Associate Professor Associate Chief Erik Garpestad, MD Associate Professor MICU Director Maher Ghamloush, MD Assistant Professor Director, Pathology Conference Series Khalid Ismail, MD Assistant Professor Program Director, Sleep Medicine Fellowship Usamah Kayyali, PhD, MPH, DPAT Associate Professor Special and Scientific staff Sucharita Kher, MD Assistant Professor Director, Divisional Outpatient Services Sebastian Kurz, MD, PhD* Assistant Professor Po-Shun Lee, MD Associate Staff Michael McBrine, MD Assistant Professor ICU Co-director, BIDMC/Jordan Hospital Pulmonary Function Lab Director Ioana Preston, MD Assistant Professor Co-Director, Pulmonary Hypertension Center Imrana Qawi, MD Assistant Professor Director, Pulmonary/Critical Care Ultrasound Services Medical Director, Bronchoscopy Service Kari Roberts, MD Associate Professor Associate Program Director, Internal Medicine Residency Program Russel Roberts, Pharm D* Adjunct Associate Professor Senior Clinical Pharmacy Specialist Director, Outpatient Pulmonary Clinic Director, Lowell General and Saints MC ICUs Greg Schumaker, MD Assistant Professor Medical Director, Rapid Response Team Medical Director, Clinical Resource Nurse Program Amy Simon, MD Adjunct Associate Professor Director, Asthma Center Program Director, Fellowship Program Maher Tabba, MD, FACP Associate Professor Director, Pulmonary Interventional Service Deniz Toksoz, PhD Associate Professor Special and Scientific staff

* New member in 2014

101 Major Clinical Programs The Pulmonary, Critical Care and Sleep Division at Tufts Medical Center offers a broad array of clinical services.

The Critical Care Program, under Dr. Erik Garpestad, oversees the delivery of medical critical care at Tufts Medical Center. The program provides daytime coverage by a board-certified intensivist seven days a week, as well as nightly phone coverage by fellows and attendings. Dr. Amy Chi serves as Associate Director of the ICU at Winchester Hospital. Fellows cover this unit with attending backup for 12 hours, five days a week, and the Division coordinates coverage by intensivists on evenings and weekends. The Division also provides daytime coverage and overall direction of two ICUs at Lowell General Hospital and Saints Medical Center, respectively, under the direction of Greg Schumaker, MD. » » PULMONARY, CRITICAL CARE AND SLEEP MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION The Center for Sleep Medicine, under Dr. Carolyn D’Ambrosio, provides diagnostic and therapeutic services for patients with a variety of sleep-related disorders. It consists of an eight-bed, fully accredited sleep laboratory at Tufts Medical Center. It serves as an important educational resource for the Pulmonary and Critical Care Fellowship Program.

The Bronchoscopy Service, under Dr. Kari Roberts, offers diagnostic and therapeutic bronchoscopies for inpatients and outpatients attending Tufts Medical Center.

The Pulmonary Interventional Service, under Dr. Maher Tabba, offers a wide range of advanced pulmonary interventional procedures that include percutaneous placement of tracheostomy tubes, placement of stents for airway narrowing, medical thoracoscopy and other pleural procedures including thoracoscopy drainage and pleurodesis. Plans are in place to obtain fluorescent technology to identify occult airway cancers.

The Division also offers numerous outpatient general and specialty clinics for asthma, sleep disorders and pulmonary hypertension.

Teaching Activities The Division teaches the second-year pathophysiology course at Tufts University School of Medicine, providing didactic lectures and leading small discussion groups. Third-year clerkships are available on the Pulmonary ward service. A number of Pulmonary attendings have been recognized by medical students for their teaching.

Fourth-year clerkships are available in the MICU at Tufts Medical Center and at the Winchester Hospital ICU. Electives are also available on the Pulmonary consultation service, as well as in the Sleep Laboratory and on the Pulmonary Interventional Service under Maher Tabba. Medical residents experience rotations on the Pulmonary ward and MICU services, and may choose electives on the Pulmonary consultation service. Division members have received many teaching awards.

There are ACGME-accredited fellowships in Pulmonary and Critical Care medicine, as well as in Sleep Medicine. The Division also offers unaccredited fellowships in interventional medicine and pulmonary vascular disease. There are three fellows in each year of the three-year Pulmonary Critical Care fellowship, and there is an option for additional years for those wishing a more in-depth research experience. The Sleep Fellowship has one position per year.

Fellows rotate through the ICUs and consultation rotations at Tufts MC during their first year. During the second and third years, fellows serve as the in-house intensivist at the Winchester Hospital ICU, at the ICUs at Lowell General and Saints Medical Center, and pursue research interests. These can be in a wide range of areas including basic, translational and clinical pulmonology. Fellows are encouraged to collaborate with investigators at other institutions if additional expertise is desired. Most graduates have taken clinical academic positions or have gone into clinical practice, and some have pursued basic science or clinical research careers

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Research Activities Clinical Research Support The ongoing clinical research projects within the Division have an annual budget of approximately $480,000.

Recipient Funding Source Purpose of Award Phase 3b study of macitentan in patients with pulmonary arterial Actelion hypertension to psychometrically validate the PAH-SYMPACT instrument »

Actelion Long-term effect of combination therapy with Bosentan and sildenafil » PULMONARY, CRITICAL CARE AND SLEEP MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION Study to assess the safety and tolerabllity of ACT-064992 in patients Actelion with symptomatic pulmonary arterial hypertension (blinded and open label) A post-marketing observational study to assess respiratory tract United Therapeutics adverse events in pulmonary arterial hypertension patients treated with Tyvaso (treprostinil) inhalation solution An open-label extension trial of UT-15C SR in subjects with pulmonary United Therapeutics arterial hypertension A phase III, international, multi-center, randomized, double-blind, placebo-controlled, clinical worsening study of UT-15C in subjects United Therapeutics with pulmonary arterial hypertension receiving background oral monotherapy Long-term efficacy of Ambrisentan on pulmonary hypertension Gilead patients Pulmonary Division Evaluation of endothelial progenitor cells in pulmonary hypertension Comparison of inhaled nitric oxide versus inhaled epoprostenol as Pulmonary Division acute pulmonary vasodilators Pulmonary Division Database and DNA tissue bank in pulmonary hypertension Chest Foundation Respironics Enhancing utilization of non-invasive ventilation in critical care Nicholas Hill, MD Assesses the effect of an up- front combination of Tadalafil and Gilead Ambrisentan compared to each drug alone in patients with pulmonary arterial hypertension Pulmonary Division Sleep during non-invasive ventilation in the ICU Use of dexmetatomidine as sedative agent during non-invasive Hospira ventilation A Phase II, randomized, double-blind, placebo-controlled study Hoffman-La Roche to assess the efficacy and safety of Lebrikizumab in patients with idiopathic pulmonary fibrosis Pulmonary Division Evaluation of total face mask for non-invasive ventilation

INO Therapeutics LLC Determines safety, tolerability and efficacy of pulsed, inhaled nitric oxide versus placebo as add-on therapy in symptomatic subjects with Ikaria, Inc. pulmonary arterial hypertension Examines natural history of scleroderma in registry centered at PHAROS Georgetown Medical Center Effect of noninvasive open ventilation (NICU) on work of breathing in Breathe Technologies COPD patients An open-label phase IIIb study of riociguat in patients with inoperable CTEPH or recurrent or persisting PH after surgical treatment who Bayer are not satisfactorily treated and cannot participate in any other CTEPH trial Randomized placebo controlled trial of Treprostinil and Tadalafil vs. Investigator-initiated Treprostinil alone in patients with pulmonary arterial hypertension. Centered at RI Hospital

103 Research Activities (continued)

Recipient Funding Source Purpose of Award A dose-ranging study of the efficacy and safety of bardoxolone REATA Pharmaceuticals methyl in patients with pulmonary arterial hypertension High intensity non-invasive positive pressure ventilation (NPPV) for Respironics stable hypercapnic COPD patients Fisher & Paykel Health Pilot study of optiflow as a NIV rest therapy Nicholas Hill, MD (continued) A Phase 2 randomized, double-blind, placebo-controlled multi- »

» Gilead center study to assess the efficacy and safety of GS-6624 in PULMONARY, CRITICAL CARE AND SLEEP MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION subjects with idiopathic pulmonary fibrosis National biological sample and data repository for pulmonary NIH/NHLBI arterial hypertension The Steroid Sparing Effects of Omalizumab in Non-Cystic Fibrosis Sucharita Kher, MD Novartis ABPA Gilead Ambrisentan in portopulmonary hypertension Actelion Opus Registry/OPsumit Users Registry Motion – a Phase IV, prospective, single arm, open-label study to Bayer HealthCare measure outcomes in patients with PAH not on active treatment Respite – An open-label, international multicenter, single arm, Bayer HealthCare uncontrolled, phase 3b study of riociguat response to treatment Ioana Preston, MD with phosphosdiesterase-5 inhibitors (PDE-5i) Brigham and Women’s The combination Ambrisentan plus Spironolactone in PAH A Phase 2, dose-ranging, randomized, double-blind, placebo- Gilead controlled study of GS-4997 in subjects with PAH Pharos – Pulmonary hypertension assessment and recognition of George Washington Univ outcomes in scleroderma Pulmonary Division Database and tissue bank for study of pulmonary hypertension Kari Roberts, MD NIH/NHLBI Estrogen signaling in portopulmonary hypertension

Basic Research Support For the past 43 years the Division has been actively involved in NIH-supported research programs that have utilized biochemical, cell biologic and molecular biologic systems to study pulmonary disease. A variety of investigators from the Division, including both MDs and PhDs, have performed these studies. Members of the Division regularly participate in national advisory and grant review committees. The Division has received present research grant support totaling $600,000.

Recipient Funding Source Purpose of Award Determine the role of endothelial and angiotension receptor NIH/NHLBI signaling in pulmonary hypertension. (Peter Polgar, PI) (Nicholas Hill, co-investigator) Exploring the trends of use of noninvasive ventilation in COPD Nicholas Hill, MD over the past decade using a large multi-hospital database and NIH/NHLBI to determine barriers to greater use. (Lindenauer, PI; Hill, co- investigator) Evaluation of neutral endopeptidase inhibitor + nitric oxide in rates Genzyme with pulmonary hypertension induced by monocrotalins

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Recipient Funding Source Purpose of Award Determine the role of the serotonin transporter in serotonylation of cellular proteins, including fibronectin, that leads to smooth Barry Fanburg, MD NIH/NHLBI muscle cell proliferation and migration and development of pulmonary hypertension (Hill, collaborator; Toksoz, co-investigator) Demonstrate how inactivation of p38 MAP kinase signaling by

Usamah Kayyali, PhD NIH-NHLBI anthrax lethal toxin leads to the vascular leak associated with » » anthrax lethality MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION Targeted Rho Kinase-1 KO mouse model for vascular smooth Deniz Toksoz, PhD NIH/NHLBI muscle remodeling

Honors and Awards

Nicholas Hill, MD (selected items) »» Invited lectures: "NIV: Compare and Contrast Adult and Pediatric Technology and Management Strategy"; "NIV: Noninvasive Ventilation for Primary Respiratory Failure." 43rd Critical Care Congress, Society of Critical Care Medicine. Post Graduate Course Speaker. San Francisco, CA »» Invited lectures: "Molecular Mechanisms and Treatment of Heart and Lung Disease." Joint Symposium, Excellence Cluster Cardiopulmonary Systems (ECCPS) and Pulmonary Vascular Research Institute (PVRI). Robin Barst Memorial Lecture: "Pulmonary Vascular Abnormalities in Lung Disease from a Global Perspective." Bad Nauheim, Germany »» Invited lecture: "High Flow Nasal O2. What is it? How do we use it?" 37th Annual Meeting and Educational Conference, NAMDRC. Sonoma, CA »» Invited lecture: "Long-Term Applications of NIV." Pulmonary Grand Rounds. Lahey Hospital and Medical Center, Burlington, MA »» Invited lecture: "Non-Invasive Ventilation: News, Use and Abuse." 6th Critical Care Symposium; Lead and Improve Outcomes. Long Beach Memorial Medical Center, Long Beach, CA »» Invited lectures: "From Bench to Clinic: A Case-Based Approval; Diagnostic Dilemmas Part I". Scientific Symposium: Dispelling Myths and Promoting Health Research Partnerships between Academia and Industry: "Strategies for Integrating Industry Support into an Academic Pulmonary and Critical Care Medicine Research Program; Progress or Peril". American Thoracic Society International Conference, San Diego, CA »» Invited lecture: "Non-Invasive Ventilation: Use, Abuse and News:. 6th Annual Joseph and Suzanne Seidemann Lectureship in Pulmonary and Critical Care Medicine, Rutgers Robert Wood Johnson Medical School. New Brunswick, NJ »» Invited lecture: "Inhaled Drugs for Pulmonary Hypertension." American Association for Respiratory Care, AARC. ACRF for Conference Drug in PH. St. Petersburg, FL »» Invited lectures: "Current Management of Pulmonary Hypertension." Simply Speaking, Albany, NY and Miami, FL »» Chair - Symposium for Fellows. Prime Symposium for PAH. Lecture: Pathophysiology: Prostacyclines for PAH" and "New Directions". Chicago, IL »» Invited lectures: "OSA and Cardiovascular Co-Morbidities", "Assessment and Management of Sleep-Disordered Breathing in Chronic Respiratory Failure" and NIV for Chronic Respiratory Failure." The Alaska Sleep Conference, Anchorage, AK »» Invited lecture: "An Overall View of Non-Invasive Mechanical Ventilation in ALI/ARDS: Are we Wasting our Time or is There Real Benefit from this Modality?" The 18th Annual Thomas J. Godar Pulmonary/Critical Care Symposium. Saint Francis Hospital, Hartford, CT »» Invited lecture: "NIV; Where have we Been, Where are we Going". Medical Grand Rounds, Weill Cornell Medical Center, New York, NY »» Faculty, Postgraduate Course. CHEST 2014, the American College of Chest Physicians Annual Meeting. "Leadership Development Course: A Conversation with Dr. Hill: A Leader's Personal Journey." Non-CME Symposium: The Evolution of Clinical Management in PAH: Perspectives on Treatment Approaches." Austin, TX

105 »» Invited lectures and Faculty: "Noninvasive Ventilation for Chronic Lung Disease," "What's New in Pulmonary Hypertension," "Pulmonary Hypertension - Are we Making Progress?", "Noninvasive Ventilation: The Horizon is Expanding." Bali, Indonesia »» Moderator: "Mechanical Ventilation and Weaning." Canadian Critical Care Forum. Editorial Comment: "Mechanical Ventilation - Focus on NIV." Toronto, CA »» Course Director: 12th Annual Update in Pulmonary Hypertension Symposium. Concurrent Patient Session; Patient Questions & Answers. "The New Meds: What are they? How are they used?" Plenary Session: "Inhaled Therapies are very much Alive" and "What's New in Endothelial Receptor Antagonists?" Cambridge, MA »» Invited lecture: "Diaphragm Paralysis - Diagnosis and Therapy." Medical Grand Rounds, Metrowest Medical Center, Natick, MA

» »» Boston Magazine's "Top Doctors" » PULMONARY, CRITICAL CARE AND SLEEP MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION

Christina Anderlind, MD »» Invited lecture: "Pulmonary Nodules", Lemuel Shattuck Hospital, Boston, MA »» Invited lecture: "Pulmonary Infiltrates in the Immune Compromised", Lemuel Shattuck Hospital, Boston, MA

Scott Epstein, MD »» Panel Member, Liberation from Mechanical Ventilation: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline

Erik Garpestad, MD »» American Thoracic Society membership subcommittee »» Boston Magazine's "Top Doctors"

Usamah Kayyali, PhD »» Invited lecture: "Targeting Signaling that Regulates the Cytoskeleton in Lung Disease", NIH, National Heart, Lung and Blood Institute, Lung Division, Bethesda, MD »» American Thoracic Society International Conference, three presentations; San Diego, CA »» Grant reviewer for the NIH Respiratory Integrative Biology and Translational Research Study Section »» Grant reviewer for the NIH-HLBP Program Project Review Workgroup 014 »» Grant reviewer for the NIH-ZHL1 CSR-P (S1) Clinical Centers for Pulmonary Vascular Disease Phenomics »» Grant reviewer for the State of California Tobacco-Related Disease Research Program

Sucharita Kher, MD »» Quality Improvement Academy II: Committee on "Moving through your visit". Taskforce focused on improving patient experience during an outpatient visit. »» Member, Taskforce on Older Adults with Asthma in Massachusetts. Department of Public Health »» Women in Medicine Committee, Tufts Medical Center, Department of Medicine

Ioana Preston, MD »» American Thoracic Society International Conference. Chair of postgraduate course and speaker; "Update in Pulmonary Hypertension" and "Current Phenotypes in PAH". Research Presentation "Effect of Warfarin Treatment on Survival of Patients with PAH", REVEAL Registry. San Diego, CA »» Invited lecture: "Pulmonary Hypertension in Pregnancy". Pulmonary Vascular Research Institute, Giessen, Germany »» Invited lecture: "Chronic Thromboembolic Pulmonary Hypertension". European Respiratory Society Annual Congress. Munich, Germany »» CHEST 2014; the American College of Chest Physicians Annual Meeting. Chair of the Scientific Oral Poster Presentation in Pulmonary Hypertension. San Antonio, TX

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» Invited lecture: "Diagnosing Chronic Thromboembolic Pulmonary Hypertension". European Pulmonary Hypertension Forum. Frankfurt, Germany »» 12th Annual Update in Pulmonary Hypertension Symposium. Co-Director and Discussion leader; "Pulmonary Artery Hypertension: New Molecules & New Insights" Cambridge, MA »» Invited lecture: "Pulmonary Hypertension Associated with Sarcoidosis". International Heart and Lung Transplant Society Meeting. San Diego, CA »» Invited lecture: "Chronic Thromboembolic Pulmonary Hypertension; an Update". LXXIII Congress of Pneumology and Thoracic Surgery. Queretaro, Mexico

»» Invited lecture: "Pulmonary Arterial Hypertension; What the Future Holds". Pulmonary Hypertension Association meeting. » » Indianapolis, IN MEDICINE SLEEP AND CARE CRITICAL PULMONARY, OF DIVISION »» Invited lecture: "Update on Chronic Thromboembolic Pulmonary Hypertension". Latin American Respiratory Society Meeting. Medellin, Colombia »» Women in Medicine Committee, Tufts Medical Center, Department of Medicine »» IRB Committee Member, Tufts Medical Center »» Research Advocacy Committee member, American Thoracic Society »» Chair, Educational Committee, Pulmonary Hypertension Association »» Scientific Leadership Council member, Pulmonary Hypertension Association »» Grant reviewer for the National Institutes of Health, American Heart Association and Department of Defense

Kari Roberts, MD »» 12th Annual Update in Pulmonary Hypertension Symposium. Co-Director and Moderator; "Functional Class II, IIIa PAH". Cambridge, MA »» American Thoracic Society Programming Committee, Pulmonary Circulation Assembly »» Chair, Networking Subcommittee, Tufts Medical Center »» Women in Medicine Committee, Tufts Medical Center, Department of Medicine »» American Thoracic Society Members in Transition and Training Committee »» Pharmacy and Therapeutics Committee Member, Tufts Medical Center »» TUSM Notable Teaching recognition, Medicine Clerkship, third-year students »» Boston Magazine's "Top Doctors", Pulmonary Medicine

Greg Schumaker, MD »» Invited lecture: "Updates on Sepsis", Grand Rounds, Lowell General Hospital, Lowell, MA »» Invited lecture: "Sepsis Management" Lowell Cardiovascular Conference, Lowell, MA »» Co-Chair, VAP Prevention Task Force, Tufts Medical Center »» Co-Chair, Pneumonia Care Committee, Tufts Medical Center »» Co-Chair, Rapid Response Task Force, Tufts Medical Center »» UIT Prevention Task Force member, Tufts Medical Center »» Critical Care Committee member, Tufts Medical Center

107 DIVISION OF RHEUMATOLOGY

The Division of Rheumatology offers comprehensive evaluation, consultation, and management of arthritis » » RHEUMATOLOGY OF DIVISION and rheumatic disease. The clinical practice focuses on diagnosis and treatment of the full spectrum of musculoskeletal and autoimmune rheumatic disorders.

Research in the Division is centered on investigations of the pathogenesis of osteoarthritis, new quantitative methods to measure its progression, and clinical trials of disease-modifying investigational treatments. There is an active program in the use of Tai Chi for chronic rheumatic diseases such as osteoarthritis, fibromyalgia, and systemic lupus erythematosus. Timothy McAlindon, MD The Center for Treatment Comparison and Integrative Analysis (CTCIA) generates evidence reports, health technology assessments, and clinical practice guidelines. Highlights of 2014

»» Dr. Senada Arabelovic was awarded a Medical Student Clinical Preceptorship Grant

»» Dr. Raveendhara Bannuru obtained a PhD in clinical and translational science from Tufts University

»» Dr. Steven Vlad was appointed to the faculty of the Tufts CTSI (Research Design Center)

»» Dr. Chenchen Wang was promoted to Professor of Medicine at Tufts University of Medicine

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Faculty

Name Academic Rank Title and Special Responsibility Pediatric/Adult Transitional Clinic »

Senada Arabelovic, DO Assistant Professor Associate Program Director of Fellowship & » RHEUMATOLOGY OF DIVISION Course Director for Medical Student on Electives Director, Center for Treatment Comparison & Raveendhara Bannuru, MD, PhD Assistant Professor Integrative Analysis Juan Canoso, MD Adjunct Professor Clinical Anatomy Jeffrey Driban, PhD Assistant Professor Research Aleksander Feoktistov, MD Adjunct Assistant Professor Musculoskeletal Ultrasound Program William Harvey, MD, MSc Assistant Professor Clinical Director Robert Kalish, MD Associate Professor Program Director Grace Lo, MD Adjunct Assistant Professor Osteoarticular Research Program Timothy McAlindon, MD, MPH Professor Division Chief Steven Vlad, MD, PhD Assistant Professor Industry Sponsored Clinical Trials Director, Center for Complementary and Chenchen Wang, MD, MSc Professor Integrative Medicine Janeth Yinh, MD Assistant Professor Musculoskeletal Ultrasound Program

Major Clinical Programs The Center for Arthritis and Rheumatic Diseases The Center for Arthritis and Rheumatic Diseases provides ambulatory consultation and follow-up as well as inpatient consultation services. The spectrum of rheumatic disorders treated by the Rheumatology Division is broad and encompasses musculoskeletal disorders and complex autoimmune diseases. Areas of expertise include ankylosing spondylitis, autoimmune rheumatic disorders, bone health, bursitis and tendonitis, gout, inflammatory muscle diseases, lupus, Lyme disease, osteoarthritis, psoriatic arthritis, rheumatoid arthritis, and vasculitis. Several members of the division have expertise in Musculoskeletal Ultrasound. The division also has a newly establish weekly urgent care clinic to accommodate urgent referrals for diagnosis or treatment of acute or severe presentations in rheumatic disease. The Division's six faculty and two fellows see approximately 6,000 visits per year.

The Division strives to advance all three aspects of its mission; patient care, education, and research. Emphasis on achieving these goals include diversifying services, building networks with community physicians and neighborhood hospitals, offering high quality patient-oriented services, and developing clinically-relevant research programs.

Musculoskeletal Ultrasound Program To improve the care of patients, the Division has adopted the use of musculoskeletal ultrasound. This non-invasive imaging technique provides an enhanced musculoskeletal evaluation that avoids exposure to the ionizing radiation associated with other imaging techniques. Several of the faculty are skilled in its use and have designed a teaching series to introduce trainees to this modality. Musculoskeletal ultrasound allows the dynamic assessment of joint and tendon movements in a manner not possible through other routine imaging modalities. Ultrasound-guidance facilitates the aspiration and injection of musculoskeletal tissues, improves diagnostic accuracy and therapeutic effectiveness, and is valuable for research in rheumatology.

109 Pediatric/Adult Transitional Clinic The clinic is designed to transition pediatric patients with autoimmune disorders who have been followed at the Floating Hospital for Children into an adult setting. The patients are seen by Dr. Senada Arabelovic.

Lyme Disease Specialty Clinic Dr. Robert Kalish offers a weekly Lyme disease clinic in which patients are assessed for complex issues regarding the diagnosis and treatment of Lyme disease. Dr. Kalish has long been involved in Lyme disease research, first studying the humoral immune response in patients with Lyme arthritis in the 1990’s, and subsequently participating in a long-term follow-up study of patients with Lyme disease in the Lyme, Connecticut area. He is invited regularly to speak on Lyme » »

RHEUMATOLOGY OF DIVISION disease for Medical Grand Rounds conferences.

Teaching Activities Tufts University medical students from each of the four years rotate through the division. First year students have the option of a selective with Dr. Kalish or other faculty. Second year students receive lectures by the division’s faculty in the Musculoskeletal Pathophysiology course that is directed by Dr. Kalish. Fourth year medical students have the option of completing a one month rotation in Rheumatology.

The Rheumatology Division conducts is involved in teaching medial students, residents, and fellows. Second and third year residents rotate through the division and participate in the outpatient clinic and inpatient consultation services.

The Rheumatology Fellowship is a two year clinical and research based program that provide training for physicians interested in specializing in Rheumatology. Each year, the division enrolls one new fellow and graduates physicians into successful academic and clinical positions. Weekly educational conferences in the division include Rheumatology Grand Rounds, Rheumatology Case Conference/Journal Club and Rheumatology Radiology Rounds.

Research Activities Osteoarthritis (OA) The goals of this program are to advance the understanding of OA pathophysiology and to seek new disease-modifying interventions. A critical component is the development of valid outcome measures for OA progression that are sensitive to change. Techniques being explored include quantitative imaging of articular cartilage, assessment of peri-articular bone morphology using MRI, dual x-ray absorptiometry, gait analysis, and the testing of physical function. These approaches are addressed through epidemiologic collaborations with the Osteoarthritis Initiative consortium and through clinical trials. Disease- modification trials of intra-articular corticosteroids, vitamin D, collagen hydrolysate, and osteogenic protein 1 are completed or in progress. The research program is funded by grants from the NIH, the American College of Rheumatology Research & Education Fund, and by sponsorship from industry.

Center for Complementary and Integrative Medicine The Center for Complementary and Integrative Medicine (CCIM) has been established within the Division of Rheumatology in the Department of Medicine at Tufts Medical Center.

The primary mission of the CCIM is to improve health outcomes for patients with chronic medical conditions. The CCIM focuses on the rigorous evaluation and investigation of cost-effective methods of complementary and alternative medicine

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 therapies. The center strives to integrate evidence-based, multi-disciplinary therapies into conventional care plans for chronic disease prevention and treatment, providing high-quality clinical care to patients. The CCIM fosters informed and knowledgeable patients, doctors and researchers through education fueled by national and international collaboration

The CCIM has three major areas of focus:

»» To conduct clinical research projects in therapies, specifically mind-body medicines. »» To provide ongoing professional development for predoctoral and postdoctoral candidates and related healthcare professionals. »» To implement and integrate scientific, evidence-based therapies into conventional medical practice, including Tai Chi mind-body therapy, acupuncture and massage therapy. » » RHEUMATOLOGY OF DIVISION Center for Treatment Comparison and Integrative Analysis (CTCIA) The Center for Treatment Comparison and Integrative Analysis Network of treatment comparisons for pain. (CTCIA) has been established within the Division of Rheumatology at Tufts Medical Center. Using advanced evidence-based methodologies; the CTCIA helps to answer a host of clinical, regulatory and health policy questions.

The CTCIA specializes in the development of evidence reports and utilizes advanced meta-analysis methods to help connect research with effective practice and guide informed policy decisions. The center also provides assistance for international panels of experts in the development of guidelines, supporting the development process with evidence and methodological support. These evidence reports have had a significant impact in health policy nationally and internationally. Using innovative approaches the center has successfully assisted clients in the regulatory process while securing FDA approvals and labeling changes. This year the center has published osteoarthritis guidelines in partnership with Osteoarthritis Research Society International. The center also published few other important studies which garnered a significant amount of national and international media attention.

The CTCIA has three primary areas of focus:

»» To develop state-of-the-art evidence reports and technology assessments »» To assist expert panels in developing evidence-based clinical practice guidelines. »» To employ advanced comparative effectiveness research techniques to support FDA approval/regulatory processes.

Industry-Sponsored Trials The sponsored trial program is supported by a clinical research coordinators and research assistants. The wide range of pharmaceuticals tested range from new small molecules for fibromyalgia to biologics for immunologic disorders and osteoarthritis to intra-articular substances for knee osteoarthritis. . The current panel of sponsored trials includes:

»» A multi-center, parallel, couble-blind, randomized, placebo-conrolled study to evaluate the safety and effectiveness of HYMOVIS®, a new viscoelastic hydrogel, for the streatment of osteoarthritis of the knee »» A phase 1, placebo-controlled, double-blind, dose-escalation study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of SM04690 injected in the target knee joint of moderately to severe symptomatic osteoarthritis subjects »» A phase 2a study evaluating the safety, efficacy, and pharmacodynamics effects of ABT-981 in patients with knee osteoarthritis »» A randomized, double-blind, placebo- and active-controlled study of DS-5565 in subjects with pain associated with fibromyalgia »» A randomized, double-blind trial assessing the impact of methotrexate discontinuation on the efficacy of subcutaneous tocilizumab with methotrexate therapy »» BOTOX® efficacy and safety in the treatment of knee osteoarthritis

111 Research Support Highlights

Name Title Funding Source Purpose of Award Rheumatology Research Senada Arabelovic, MD Principal Investigator Medical Student Clinical Preceptorship Foundation Comparative safety profile on Synvisc® for Principal Investigator Genzyme knee osteoarthritis: a systematic review and network meta-analysis Raveendhara Bannuru, MD, Co-Principal Clinical practice guideline development for

» PhD, FAGE ACR

» Investigator Rheumatoid Arthritis RHEUMATOLOGY OF DIVISION Osteoarthritis Research Development of clinical guidelines for Investigator Society International osteoarthritis treatment Clinical Trial of Tai Chi & Physican Therapy for Co-Investigator NIH Knee Osteoarthritis Clinical Trial of Tai Chi and Aerobic Co-Investigator NIH Jeffrey B. Driban, PhD, Exercise of Fibromyalgia ATC, CSCS Rapid Quantitative composite MRI measurement Co-Investigator NIH of Knee OA structural progression Principal Characterizaion of Rapidly Progressive NIH Investigator Knee Osteoarthritis Clinical Trial of Tai Chi & Physical Therapy for Co-Investigator NIH Knee Osteoarthritis Fidia, Samumed, Co-Investigator 4 Clinical Trials in Knee Osteoarthritis Allergan, Abbvie William Harvey, MD, MSc Effect of intra-articular steroids on structural Co-Investigator NIH progression of knee OA: an RCT Clinical Trial of Tai Chi and Aerobic Exercise for Co-Investigator NIH Fibromyalgia Principal Investigator Gilead Research Contract Rheumatology Research Amgen/Wyeth Rheumatology Fellowship Training Robert Kalish, MD Principal Investigator Foundation Award Effect of intra-articular steroids on structural Principal Investigator NIH/NIAMS progression of knee OA: an RCT Periarticular Bone Density as Biomarker for Principal Investigator NIH/NIAMS early Knee OA Co-Investigator NIH/NIAMS Efficacy of CAM on Patient Centered Outcomes Rapid quantitative composite MRI measurement Principal Investigator NIH/NIAMS of Knee OA structural progression Co-Principal Clinical practice guideline development for ACR Investigator Rheumatoid Arthritis Timothy McAlindon, MD, MPH Constitutional and Metabolic Factors associated Principal Investigator NIH/NIAMS with the development of Hand OA Co-Principal Characterization of Rapidly Progressive Knee NIH/NIAMS Investigator Osteoarthritis A Method for Patient-Centered Enrollment in Co-Principal PCORI Comparative Effectiveness Trials: Mathematical Investigator Equipoise Co-Principal NIH/NCCAM Tai Chi and Knee Osteoarthritis Investigator

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Name Title Funding Source Purpose of Award Co-Principal NIH/NCCAM Tai Chi and Fibromyalgia Investigator

Timothy McAlindon, MD, MPH Prevention and Treatment of Osteoarthritis Osteoarthritis Research through the Promotion and Presentation Principal Investigator Society International of Research, Education, and the Worldwide Dissemination of New Knowledge. »

Site Principal Genentech, Daiichi- Clinical trials of drugs for rheumatoid arthritis » Steven Vlad, MD, PhD RHEUMATOLOGY OF DIVISION Investigator Sankyo and fibromyalgia Clinical Trial of Tai Chi and Aerobic Exercise for Principal Investigator NIH/NCCAM Fibromyalgia Midcareer Investigator Award in Patient-Oriented Principal Investigator NIH/NCCAM Research Clinical Trial of Tai Chi and Physical Therapy for Principal Investigator NCCAM Knee Osteoarthritis Mentoring & Research in Patient-Oriented Principal Investigator NCCAM/NIH Integrative Medicine Clinical Trial of Tai Chi Mind-Body for the Chenchen Wang, MD Principal Investigator NIH/NCCAM Treatment of Post-Traumatic Stress Disorder A Randomized Controlled Trial of Tai Chi for Donaldson Charitable Primary Mentor Breast Cancer Survivors with Aromatase Inhibitor Trust Foundation associated Arthralgias 2014 Tufts Summer Functional Balance and Well-being among Primary Mentor Medical Student Patients with Fibromyalgia Research Fellowship Traditional Chinese Mentoring and Clinical Research Training in Primary Mentor Medicine Universities Chinese Investigators

Honors and Awards

Raveendhara Bannuru, MD, PhD »» Faculty of 1000 international award for excellent research presented at the Osteoarthritis Research Society International 2014 World Congress, Paris, France »» Plenary keynote speaker at the Mexican Federation of Orthopedic and Traumatology College (FEMECOT) 25th Congress (annual meeting) held on October 21-25, 2014 in Leon, Guanajuato, Mexico »» Session moderator: Annual Scientific Meeting of American College of Rheumatology, Boston, MA, USA, November 2014 »» Appeared in interviews with WBZ Channel 4/ CBS Boston, Boston Globe, and Reuters on the shockwave therapy article published in Annals of Internal Medicine »» Advisory Committee: Postdoctoral Affairs Office for Tufts University School of Medicine »» Clinical and Translational Science Curriculum Committee for MS/PhD Graduate Program of the Tufts Clinical and Translational Science Institute and the Sackler School of Graduate Biomedical Sciences, Tufts University »» Core Expert Panel Member and Evidence Synthesis Team Leader: Osteoarthritis Treatment Guideline Development Group (OAGDG) for Osteoarthritis Research Society International »» Guidelines Core Oversight Team: American College of Rheumatology Committee on ACR Guidelines for the Treatment of »» Rheumatoid Arthritis

113 Jeffrey Driban, MD »» Research Travel Award, Tufts Medical Center »» NATA Representative to the Osteoarthritis Action Alliance »» Committee Member, National Athletic Trainers’ Association Research and Education Foundation Free Communications Subcommittee »» Associate Editor, BMC Musculoskeletal Disorders »» Committee Member, Eastern Athletic Trainers’ Association Research Committee

William Harvey, MD, MSc »» Physician Liaison for Ambulatory EHR, Tufts Medical Center »» Clinical Director, Division or Rheumatology, Tufts Medical Center »» ICD-10 Clinical Liaison, Tufts Medical Center »» Care Improvement Council, Tufts Medical Center »» Chair, Committee on Government Affairs, American College of Rheumatology »» Invited Witness, US House of Representatives Energy & Commerce Committee Hearing, June 12, 2014, Barriers to Specialty Care and Treatment

Robert Kalish, MD »» Boston Magazine. “Top Doctors” »» Tufts University School of Medicine Award for Excellence in Teaching, 2014 »» American College of Rheumatology Educational Grant Study Section »» American College of Rheumatology – State of the Art Meeting Planning Committee

Timothy McAlindon, MD MPH »» Boston Magazine. “Top Doctors” »» Co-Editor, Arthritis and Rheumatism »» Board of Directors, OARSI »» Committee Chair, OARSI OA Treatment Guidelines »» ACR RA Clinical Treatment Guidelines, literature Review Team Leader

Steven Vlad, MD PhD »» Tufts University School of Medicine Curriculum Committee

Chenchen Wang MD, MSc »» Excellence Presentation Award in 2014 Beijing International Acupuncture and Neurology Seminar, Beijing, China »» Excellence Presentation Award in 2014 International Congress of Oriental Medicine in Taipei, Taiwan. »» Outstanding Research Award, the 2014 International Tai Chi Symposium, Las Vegas, US »» Dr. Chenchen Wang was promoted as Professor of Medicine at Tufts University of Medicine

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 115

THE INSTITUTES

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Tufts Medical Center has three Institutes which are nationally known for their basic and clinical research activities. The Institutes do not report directly to the Department of Medicine but many of their members carry out clinical activities within the various divisions. INSTITUTE FOR CLINICAL RESEARCH AND HEALTH POLICY STUDIES » » INSTITUTE FOR The Institute for Clinical Research and Health Policy Studies (ICRHPS) is a hospital-wide enterprise that includes members of many clinical departments of Tufts Medical Center. Academic appointments and clinical activities of

CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Institute members are conducted through the Division of Clinical Care Research (CCR) of the Department of Medicine. In addition, some faculty members have clinical appointments in departments other than the Department of Medicine. These cross-appointments enhance research and the leadership role of the Institute in the broader Tufts campus.

About half of the Institute’s research is federally supported, primarily by the National Institutes of Health (NIH) and the Patient Care Outcomes Research Institute (PCORI). The Institute’s research involves the study of clinical features of disease; the optimal use of treatments and of evidence; measurement of the outcomes of healthcare interventions; and the influence of socioeconomic, organizational, and policy factors on healthcare. Over the past 20 years, as a result of ICRHPS/CCR-based research, Tufts Medical Center has had the world’s highest average ISI citation index in health care research, and has been most often ranked first of any institution. In addition to its research portfolio, ICRHPS has an AHRQ-funded T32 Training Program.

Through the efforts of the ICRHPS faculty, and faculty throughout the Department of Medicine and the Tufts campus, the Tufts Clinical and Translational Science Institute (Tufts CTSI) was established in August 2008 with a grant from the NIH. The CTSI’s promotion of collaborative, full-spectrum translational research has a substantial impact on the conduct of research at Tufts and at affiliated hospitals across Massachusetts and Maine. The Tufts CTSI includes the Research Design Center-Biostatistics Research Center (RDC-BRC), the Clinical and Translational Science Center (formerly the Tufts GCRC), and the Clinical and Translational Research Graduate Program of the Tufts Sackler School. The Graduate Program provides research training to ICRHPS fellows and to trainees throughout many Tufts Medical Center clinical departments and divisions. The RDC-BRC provides support to all Tufts departments and divisions in biostatistics, study design, data collection, budgetary planning, writing, and related project development. Highlights of 2014

»» Receipt of $6,162,235 in new funding for 25 new research projects in 2014

»» 72 different research projects

»» Authorship by faculty of 120 articles in over 90 different journals

»» Recognition of faculty by participation in many national panels

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 » » Faculty INSTITUTE FOR

Name Academic Rank Title and Special Responsibility Division Chief Executive Director, Institute for Clinical Research and Health CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Harry Selker, MD, MSPH Professor Policy Studies Dean, Tufts Clinical and Translational Science Institute Director, CCHSR David Adler, MD Professor, Psychiatry and Medicine Clinician-Researcher, CHS Ethan Balk, MD, MPH Associate Professor Director, CCES Joni Beshansky, RN, MPH Associate Professor (left in 4/14) Assistant Director, CCHSR Janis Breeze, MPH Instructor Epidemiologist, RDC-BRC James Chambers, PhD Assistant Professor CEVR CHS Hong Chang, PhD Assistant Professor Biostatistician, RDC-BRC Joshua Cohen, PhD Research Associate Professor CEVR Denise Daudelin, RN, MPH Assistant Professor Project Director, CCHSR Co-PI, Tufts CTSI Karen Freund, MD Professor Director, Program on Equity in Health and Science Associate Professor of Medicine and Richard Hermann, MD CHS Psychiatry Director, Clinical and Translational Research Graduate Program, Sackler School David Kent, MD, MS Professor Director, PACE CCHSR Manlik Kwong, BS Adjunct Instructor Software Engineer, CCHSR Deborah Lerner, MS, PhD Professor of Medicine and Psychiatry Director, Program on Health, Work and Productivity, CHS THI Laurel Leslie, MD Professor, Medicine and Pediatrics Tufts CTSI Pei-Jung Lin, PhD, MS Assistant Professor CEVR Thomas Mackie, PhD Assistant Professor CHS PACE Jason Nelson, MPH Instructor Biostatistician, RDC-BRC Peter Neumann, ScD Professor Director, CEVR Director, CHS Susan Parsons, MD, MRP Professor of Medicine and Pediatrics Director, Center for Child and Family Outcomes

119 Faculty (continued)

Name Academic Rank Title and Special Responsibility Associate Director and Epidemiologist RDC-BRC Jessica Paulus, ScD Assistant Professor Associate Director, Sackler Graduate Program

Lori Lyn Price, MAS Instructor Biostatistician, RDC-BRC

Gowri Raman, MD, MS Assistant Professor CCES »

» Angie Mae Rodday, MS Assistant Professor CHS INSTITUTE FOR William Rogers, PhD Research Assistant Professor CHS CHS Carolyn Rubin, EdD Assistant Professor (left 7/1/14) Tufts CTSI

CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Associate Director and Biostatistician, RDC-BRC Robin Ruthazer, MPH Assistant Professor CCHSR PACE Dana Gelb Safran, ScD Associate Professor CHS Saeid Shahraz, PhD Assistant Professor-pending PACE Djora Soeteman, PhD Assistant Professor PACE Director and Biostatistician, RDC-BRC Norma Terrin, PhD Associate Professor CHS Hocine Tighiouart, MS Instructor Biostatistician, RDC-BRC Lisa Welch, PhD Assistant Professor Evaluation Manager, Tufts CTSI

Research center abbreviations:

RDC-BRC = Research Design Center-Biostatistics Research Center CCES = Center for Clinical Evidence Synthesis CCHSR = Center for Cardiovascular Health Services Research CEVR = Center for Evaluation and Risk in Health PACE = Predictive Analytics and Comparative Effectiveness Center CHS = Center for Health Solutions (formerly The Health Institute)

Associate and Adjunct Staff Affiliations

Alawi Alsheikh-Ali, MD, MS Sheikh Khalifa Medical City, Abu Dhabi, UAE Mohan Bala, PhD, MBA Sanofi-Aventis Peter Bonis, MD Tufts Medical Center Kathleen Bungay, PharmD Northeastern University Joseph Cappelleri, PhD Pfizer, Inc Ralph D’Agostino, Sr., PhD Boston University Issa Dahabreh, MD, MS Brown University Olaf Damman, MD Tufts Medical Center Jonathan Davis, MD Tufts Medical Center Roger Fielding, MD Tufts HNRC Frederick Frankhauser, JD Tufts Medical Center Gary Freeman, MD Zoll Medical Seyyed Nassir Ghaemi, MD, MPH Tufts Medical Center Alexandra Glazier, JD, MPH New England Organ Bank

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Robert Goldberg, PhD Baystate Medical Center Elizabeth Goodman, MD Massachusetts General Hospital Alice Gottlieb, MD Tufts Medical Center William Gouveia, PharmD Tufts Medical Center Daniel Greenberg, PhD Ben Gurion University of the Negev, Israel David Greenblatt, MD Tufts University Judy Hinchey, MD Caritas St. Elizabeth’s Medical Center

Gordon Huggins, MD Tufts Medical Center » » INSTITUTE FOR John Ioannidis, MD Stanford University Bertrand Jaber, MD Caritas St. Elizabeth’s Medical Center Jeroen Jansen, PhD MAPI Group Howard Jen, MD Tufts Medical Center

Georgios Kitsios, MD, MS, PhD Lahey Clinic STUDIES POLICY HEALTH AND RESEARCH CLINICAL Richard Kopelman, MD Tufts Medical Center Jeffrey Lasker, MD NEQCA Mary Lee, MD Tufts University Andrew Levey, MD Tufts Medical Center Peter Lindenauer, MD, MSc Baystate Medical Center Alice Lichtenstein, DSc Tufts Friedman School/HNRC John Mason, PhD Blue Cross Blue Shield of Massachusetts Timothy McAlindon, MD, MPH Tufts Medical Center Kimberley McGuigan, PhD, MBA Pfizer, Inc Sandeep Menon, BHMS, MPH, PhD Pfizer, Inc Vandana Menon, MD, PhD, MPH, MS Outcome Sciences, Inc. Catherine Milch, MD, PhD Millenium Pharmaceuticals Stephen Pauker, MD Tufts Medical Center Brian Pereira, MD AMAG Pharmaceuticals, Inc. Inga Peter, PhD Mount Sinai Medical Center Thomas Pfeiffer, DNS Harvard University Rosalie Phillips, MPH Tufts Public Health Anastassio Pittas, MD Tufts Medical Center Douglas J. Reichgott Tufts Medical Center Michael Rothberg, MD Baystate Medical Center Mark Sarnak, MD, MS Tufts Medical Center Caroline Schwartz, ScD DeltaQuest Foundation Joanna Seddon, MD Tufts Medical Center Robert Sege, MD Boston Medical Center Radley Sheldrick, MD Tufts Medical Center David Snydman, MD Tufts Medical Center Paul Stark, ScD Tufts School of Dental Medicine Gary Strauss, MD Tufts Medical Center Teruhiko Terasawa, MD Fujita Health Univ School of Medicine, Japan James Udelson, MD Tufts Medical Center Katrin Ulhig, MD, MS Tufts Medical Center Chenchen Wang, PhD Tufts Medical Center Christine Wanke, MD Tufts Medical Center John Ware, PhD University of Massachusetts Medical School Elias Zintzaras, MD, PhD Univ of Thessaly School of Medicine, Greece Deborah R. Zucker, MD American Federation of Medical Research

121 Major Clinical Programs The Division of Clinical Care Research/ICRHPS has no clinical programs of its own. Physician-Researcher Division members have appointments in Internal Medicine and Adult Primary Care, Neurology, Pediatrics, and Psychiatry where they are active participants in clinical activities. Among those with primary appointments in the Division, clinical activities are as listed below:

»» Harry Selker, MD Internal Medicine and Adult Primary Care/Pratt Diagnostic Clinic

»» David Adler, MD» » »

INSTITUTE FOR Psychiatry

»» Karen Freund, MD» Internal Medicine and Adult Primary Care

»» Howard Jen, MD»

CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Pediatric Surgery

»» David Kent, MD» Internal Medicine and Adult Primary Care

»» Laurel Leslie, MD» General Pediatrics

»» Susan Parsons, MD» Adult and Pediatric Hematology- Oncology Teaching Activities Faculty in the Division of CCR/ICRHPS teach courses and seminars in clinical research methods to faculty, fellows, residents, and administrative staff. In addition to teaching at Tufts Medical Center and other Boston institutions, ICRHPS faculty have given courses around the world. Primarily, however, faculty members of the Institute are involved with the teaching activities in the Tufts Clinical and Translational Science (Tufts CTSI) Clinical Research Curriculum, MS/PhD Clinical Research Graduate Program of the Tufts Sackler School of Biomedical Sciences.

The CTS graduate program, under the direction of Dr. David Kent, aims to train the next generation of leaders and innovators in the application of methods of health services research, especially to direct improvement of clinical practice. By teaching core clinical research skills and facilitating the completion of an independent research project, the program aims to help self-motivated trainees embark on careers as clinical and health services researchers.

The CTS graduate program, the first in the nation linking an MS/PhD program in a biomedical graduate school with an academic medical center for clinical research training, has emerged as a national model. The program is designed for individuals who have completed training in the medical sciences (MD, DO, DDS, DVM, etc.), or in another advanced biomedical degree program; the majority of students are postdoctoral clinical fellows or faculty at Tufts Medical Center and other Tufts-affiliated hospitals. The program confers an MS and a PhD in Clinical Research and also provides individual courses to other non-matriculated students. Students select one of the three following concentrations which choice allows them to develop more extensive competency in their chosen area: Evidence-based Clinical Effectiveness Research, Clinical Investigation, and, Health Services and Outcomes Research. Additionally, in order to promote better interdisciplinary research education through increased comprehensiveness of the program content, the program provides students with the option of choosing a focus in another discipline, which would typically represent the content area of their thesis.

The Program has a formal mentoring system to facilitate fellows’ development and execution of independent research projects. All students enrolled in this program must complete an independent research project thesis. Visiting fellows, special fellows, and fellows from a variety of Tufts Medical Center Departments and Divisions also participate in fellowship offerings. Nearly all of the fellows who have trained in this Program are currently active faculty at medical schools or the NIH, and the rest serve as senior staff or consultants in health services delivery and policy.

Post-doctoral training is provided by the CCR federally-sponsored T32 training grant in Clinical Care and Health Services Research; A KM1 Career Development Award (KM1) Program in Comparative Effectiveness Research (CER); and, KL2 Junior Faculty Career Development Award Program faculty.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Research Activities The seven primary research programs of the Division of Clinical Care Research are listed below, followed by short descriptions of their activities.

»» Research Design Center/Biostatistics Research Center »» Center for Cardiovascular Health Services Research »» Center for Clinical Evidence Synthesis »» Center for Evaluation of Value and Risk in Health

»» Center for Health Solutions (formerly The Health Institute) » » INSTITUTE FOR −− Program for Child and Family Outcomes −− Program on Health, Work, and Productivity −− Program on Innovation in Pediatric Policy and Practice »» Predictive Analytics and Comparative Effectiveness Center CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL »» Program on Equity in Science and Health

Research Design Center/Biostatistics Research Center

(Dr. Norma Terrin, Director; Faculty: Drs. Hong Chang, Farzad Noubary, Jessica Paulus, Ms. Janis Breeze, Ms. Lori Lyn Price, Ms. Robin Ruthazer, Mr. Hocine Tighiouart) The Research Design Center/Biostatistics Research Center (RDC-BRC), a joint program between ICRHPS/CCR and the Tufts CTSI, seeks to promote innovation and excellence across the spectrum of patient-oriented research through development of new statistical and study design methods and provision of training, education and support in applying standard and cutting-edge design and analytic techniques. The RDC-BRC serves as the academic center for biostatistics at Tufts University and its affiliated teaching hospitals. It provides a forum to develop new methods, consulting strategies, and solutions to problems through internal meetings and seminars as well as through attendance at local and national meetings. BRC faculty are involved as investigators on their own investigator-initiated research as well as on projects throughout Tufts Medical Center, Tufts University, and other Tufts affiliates. RDC-BRC staff serve nationally as consultants to institutions, federal agencies, corporations and grant proposal review panels, and as members of Data Safety and Monitoring (DSMB) boards. In addition, the faculty in the RDC-BRC is responsible for statistical and computational instruction and mentoring to students in the Sackler Clinical Research Program.

Center for Cardiovascular Health Services Research

(Dr. Harry Selker, Director; Ms. Joni Beshansky, Associate Director; Faculty: Dr. David Kent, Ms. Denise Daudelin, Mr. Manlik Kwong, Ms. Robin Ruthazer) For over 25 years, the Center for Cardiovascular Health Services Research (CCHSR) has focused on the development of treatment strategies, decision aids, methods, and systems aimed at improving medical care, especially emergency and cardiac care. It is particularly known for a series of studies of factors influencing cardiac care, and for the development of clinical predictive instrument decision aids which provide diagnostic predictions for emergency physicians and paramedics in the emergency clinical care setting. These instruments can also be used retrospectively to determine the appropriateness of care. Related work has included conduct of multiple larger national clinical effectiveness trials, including demonstrating better treatment and clinical outcomes for patients with acute coronary syndromes and acute myocardial infarction.

Electrocardiographs now in common use include predictive instruments developed by Dr. Selker for cardiac ischemia and the outcomes of reperfusion therapy for ST elevation myocardial infarction (STEMI) that are printed on patients' electrocardiograms; these instruments have been shown in large trials to improve emergency care. Building on this, more recently CCHSR ran a national randomized placebo controlled trial to determine If a long-neglected treatment for AMU, an Intravenous solution of glucose, insulin, and potassium (GIK) if given very early in the course of ACS and AMI could reduce cardiac arrest and death. The results of this 871-participant study showed that although progression to AMI was not significantly reduced, the odds of having cardiac arrest or dying were reduced by half, and the size of the AMI was reduced by 80%. A second trial is planned to confirm this result, which, if true, could potentially save the lives of tens of thousands of patients in the US, each year.

123 Predictive Analytics and Comparative Effectiveness Center

(Dr. David Kent, Director; Dr. Jessica Paulus, Dr. Djora Soeteman, Dr. Saied Shahraz, Ms. Robin Ruthazer, Dr. Issa Dahabreh), The Predictive Analytics and Comparative Effectiveness Center (PACE) studies the limitations of using group-derived evidence as the basis for decision making in individual patients. The approach is based on the close integration of clinical and statistical reasoning and the goal is to provide clinicians and patients with evidence better tailored to their particular circumstances. PACE has expertise in clinical medicine, risk modeling, individual patient meta-analysis, and observational comparative effectiveness studies. Among other projects, Dr. Kent is the Principal Investigator of several

» federally-funded research grants related to this theme, including the Risk of Paradoxical Embolism (RoPE) study, an » INSTITUTE FOR international multi-site study to determine which patients are most likely to benefit from the closure of a patent foramen-ovale (compared with medical therapy) in the setting of cryptogenic stroke. A related study examines anticoagulant compared with antiplatelet therapy in the same population. A PCORI-sponsored methods project is evaluating a framework to examine heterogeneity of treatment effect across a large set of clinical trial and an NIH Common Fund to develop a framework to assess the value of providing risk information for decision making. The PACE CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Center also addresses fundamental analytic issues in how to employ a risk-modeling approach to clinical trial analysis.

Center for Clinical Evidence Synthesis

(Dr. Ethan Balk, Director; Faculty: Dr. Gowri Raman, Dr. Norma Terrin) The Center for Clinical Evidence Synthesis (CCES) promotes the application of evidence-based methods to healthcare and biomedical topics and the development of methodologies in evidence synthesis. CCES has become an internationally recognized leader in meta-analysis and evidence-based practice. Members are experts in the fields of meta-analysis, clinical data-synthesis, decision, and cost-effectiveness analysis, clinical guideline creation and evaluation and health services and outcomes research. CCES was an AHRQ-designated Evidence-based Practice Center for 15 years and continues to collaborate on these projects nation-wide. In addition, CCES members have done consulting and conducted evidence reviews under contracts from government agencies, pharmaceutical companies, and other organizations. CCES faculty are experienced teachers in critical literature appraisal and have trained multidisciplinary audiences in the conduct of evidence based reviews through curricula and programs in national and international settings. They serve as mentors to trainees and as consultants to academic and private entities in evidence appraisal.

Center for the Evaluation of Value and Risk in Health

(Dr. Peter Neumann, Director; Faculty: Drs. Joshua Cohen, James Chambers, Pei Jung Lin) The Center for the Evaluation of Value and Risk in Health (CEVR) was established in December 2005 by Peter Neumann, ScD (Director) and Joshua Cohen, PhD (Deputy Director) to focus on issues pertaining to value, cost-effectiveness, and risk tradeoffs in healthcare decisions. The mission of CEVR is to analyze the benefits, risks, and costs of strategies to improve health and health care and to communicate the findings to clinicians and policymakers. CEVR researchers undertake scientific research projects, advance methods development for the field, train the next generation of practitioners and users, and work with policymakers worldwide to develop reasoned policy solutions.

CEVR researchers bring experience in economics and decision analysis to a host of clinical and public health policy issues. Research at CEVR focuses on: 1) evaluating and comparing diverse benefit-risk tradeoffs that are central to a multitude of healthcare decisions; 2) understanding the attitudes and perceptions of value from the perspective of patients, physicians, and policymakers, and 3) applying cost-effectiveness analyses in medical and public health interventions such as preventive measures, screening and treatment for Alzheimer’s disease, cancer, and other diseases and conditions.

CEVR has developed two unique databases to help measure and communicate the clinical and economic value of health care strategies. CEVR is the home of The Tufts Cost-Effectiveness Analysis Registry, an internationally known resource containing detailed information on more than 1,700 standardized cost-effectiveness analyses published in the peer- reviewed literature (www.cearegistry.org). In addition, CEVR has developed and maintains The Tufts Medical Center Medicare National Coverage Decisions (NCDs) Database, a first of its kind that documents decisions made by the Centers for Medicare and Medicaid Services (CMS). Recent projects include a CMS Innovation Award to evaluate cloud- based technology in the critical care setting, analysis of the costs and benefits of treatments for leukemia, lymphoma,

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 and myeloma; multiple unmanaged co-morbidities in diabetes patients; factors influencing Medicare coverage of new technologies; modeling the impact of early Alzheimer's disease detection, and understanding the influence of comparative effectiveness research on coverage and reimbursement.

Center for Health Solutions

(Dr. Susan Parsons, Director; Faculty: Drs. David Adler, Hong Chang, Richard Hermann, Debra Lerner, Laurel Leslie, William Rogers, Angie Mae Rodday, Carolyn Rubin) The Center for Health Solutions, first founded In 1988 as The Health Institute (THI) at Tufts MC was home to the Medical Outcomes Study (MOS)—a landmark study designed to measure the relationship between the organization and delivery of » » medical care and the functional health outcomes of patients. The Center for Health Solutions' overall mission is to improve INSTITUTE FOR health by advancing measurement of, and knowledge about, the social, behavioral, medical and biological factors that influence individual and population health. To accomplish this goal, CHS develops tools to advance the science of outcomes measurement from the patient’s point of view; engages in large-scale research projects to examine the links between structure, process and outcomes of health care; conducts multidisciplinary research into the complex pathways linking health and its social, behavioral, medical and biological determinants; and works with clinicians, government, STUDIES POLICY HEALTH AND RESEARCH CLINICAL employers, health plans and other public and private sector organizations to translate research into practice and policy.

The principal program areas of research encompassed by CHS’s work are the following: 1) Program on Child and Family Outcomes, led by Susan Parsons, MD, MRP, studying the quality of life of families coping with a chronic illness (such as cancer or mental health disorders); 2) Program on Health, Work, and Productivity, led by Debra Lerner, MS, PhD, addresses the burgeoning need to improve the health of working people and reduce the human and economic burden of health problems on them, their families, employers, and the nation, and 3) the Program on Innovation in Pediatric Policy and Practice, led by Dr. Laurel Leslie, addresses the effective development and implementation of evidence-informed care of children and adolescents with health, developmental, and behavioral concerns cared for in community settings such as schools, pediatric clinics, and child welfare/protective services. Faculty members within CHS receive research support from a variety of sources, including federal funders (NIH, AHRQ, VA, and CDC), pharmaceutical companies, and foundations.

Program on Equity in Science and Health

(Dr. Karen Freund, Director) The Program on Equity in Science and Health addresses diversity in the biomedical workforce and disparities In healthcare delivery. The mission of the program is to address two separate but related aspects of equity through research, 1) equity in science and biomedical careers, including understanding the factors associated with recruitment, promotion, and retention of women and minority faculty in academic biomedical careers and 2) disparities in the delivery of healthcare, especially to women and minority communities. The program focuses on interventions to reduce and eliminate these disparities.Research Support

125 Research Support

Recipient Funding Source Purpose of Award Updates to Existing Systematic Reviews on Diabetes Prevention CDC and Control for the Guide to Community Preventive Services Ethan Balk, MD A Systematic Review of Selected Outcomes in Women with Plastic Surgery Foundation Silicone Breast Implants AHRQ EPC Methods Research and Support in Decision Simulation Modeling Update of a Predictive Model (1999-2013) and Evaluation of »

» AdvaMed INSTITUTE FOR Consistency with Private Payers Coverage Determination Millennium, Medtronic, and Pharma Consortium: Use of CER by Medicare for National Genentech Coverage Determining the Consistency and Transparency of Private Payer MDMA Coverage Determination for Medical Devices CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Is Coverage Policy for MS Treatment Consistent with the Bayer James Chambers, PhD Evidence? Estimating the Population Health Benefits of new Pfizer Pharmaceuticals Pfizer Disinvestment in US healthcare: Opportunities and Challenges Is Coverage Policy for Rheumatoid Arthritis Treatment Genentech Consistent with the Evidence? MITA PET: A Review of the Cost Effectiveness Evidence Base Insurance Instability and Disparities in Chronic Disease NIH/NIMH Outcomes NIH/NIGMS Longitudinal Follow up to the National Faculty Survey Karen Freund, MD PCORI via Lahey Clinic Cervical Spondolytic Myelopathy Surgical Trial NIH via Ohio State OSU Cancer Center Support Grant American Cancer Society Patient Navigation to Eliminate Cancer Disparities AHRQ via ECRI National Quality Measures Clearinghouse Project Richard Hermann, MD NIH/NIMH via UPenn Patient Safety in Inpatient Psychiatry Evaluating Observational Data Analyses: Confounding Control PCORI via Brown University and Treatment NIH Value of Personalized Risk Information (Dual PI: Peter Neumann) Targeted Antithrombotic Therapy in Cryptogenic Stroke with NIH/NINDS Patent Foramen Variation in individual treatment effects from repeated period David Kent, MD NPC cross-over studies NIH/NINDS The Risk of Paradoxical Embolism Study (RoPE) A field synopsis of sex in cardiovascular and cerebrovascular NIH/NINDS disease prediction Assessing and Reporting Heterogeneity of Treatment Effects in PCORI Clinical Trials

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Recipient Funding Source Purpose of Award Preventing Mid and Later Life Work Limitations: Community- NIH/NIMH based Depression Care Development and Implementation of a Sleep Module for the Info Tech Wellness Checkpoint

Debra Lerner, ScD VA via UPenn RD Merit Award Employer’s Health Right Direction for Addressing Workplace Depression » » Aetna Applied Research Services INSTITUTE FOR Caregivers of Individuals Diagnosed with Schizophrenia: Impact Janssen on Employment and Unmet Needs Comparative Effectiveness of Adolescent Lipid Screening and PCORI Laurel Leslie, MD Treatment Strategies STUDIES POLICY HEALTH AND RESEARCH CLINICAL American Academy of Pediatrics Pediatric Research in Office Settings The Potential Economic Impact of Chronic Disease Management ADDF in Alzheimer's Disease Prevention Nationwide Frequency and Cost of Preventable Hospitalizations Alzheimer’s Foundation in Alzheimer’s Disease Pei Jung Lin, PhD Healthcare Utilization, Expenditures, and Quality of Care of Genentech Alzheimer’s Disease BADERC: Estimating Costs of Multiple Chronic Conditions NIH via MGH among Adults with Diabetes CDC Cost Effectiveness of Cancer Interventions West Health Policy Center Economic Discontinuities in Health Care Delivery Systematic Literature Review of Adjunct Pharmacotherapy in Shire Dev, Inc Children and Adolescents with ADHD Pfizer A Catalog of Alzheimer’s Disease Data Resources Bayer Bayer Fellowship Understanding the Value of Interventions for Leukemia, LLS Lymphoma and Myeloma Sanofi Economics of Added Life Years When a Life Extending Technology is not Cost-Effective, Even if Sanofi Offered for Free Peter Neumann, ScD Medtronic Review of Degenerative Back and Leg Pain Models Cloud AWARE Program: Patient Centric Electronic Environment CMS-Medicare via BIDMC for Improving Acute Care Hospital Performance Analyze the health economic outcome variables to determine Abbott health care costs Heart Failure Module 3: Financial Impact of Reducing Amgen Hospitalization Trinity Partners The Value of Specialty Biopharmaceuticals Novartis Burden of Condition Analysis for Acute Spinal Cord Injury Economic Modeling of Amyloid Imaging Tests for Alzheimer’s GE (UK) Disease

127 Research Support (continued)

Recipient Funding Source Purpose of Award University of Eastern Finland ALSOVA Dataset Review and Novartis Analysis Biogen IDEC WTP for Newborn Screening Tests for Rare Diseases Assessment of Value to Mitigate Mobility and other Neurological Biogen IDEC Symptoms Associated with MS 2013 Cost and Affordability Research Grant (Natalia Olchanski, »

» BCBSMA

INSTITUTE FOR CEVR PI) Peter Neumann, ScD (continued) NPC FDAMA Section 114 Case Studies and Policy Implications Understanding Communications between Surgeons and Merck Anesthesiologists: Relaxant Use

CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL Robert Wood Johnson Updating the Panel on Cost-Effectiveness in Health and Foundation Medicine Bill and Melinda Gates Registry on Cost per Disability Adjusted Life Years Foundation (DALY) Studies Familial T-Cell Depleted Stem Cell Transplant in High Risk Sickle NIH via NYMC Cell Anemia Patient Navigation for Medically Underserved Breast Cancer Avon Foundation Patients Family Self Management during the Transition from Acute Care NIH via Johns Hopkins Susan Parsons, MD to Home after Pediatric Bone Marrow Transplantation Children's Hospital Collaborative Clinical Effectiveness Fund on Children's Hospital Home Vent Use Leukemia and Lymphoma Proof of Paradigm in Cost-Effectiveness Analysis with Novel Society Therapeutics Yawkey Foundation Patient Navigation Program Genetic Markers of GIK Effect in Acute Coronary Syndrome in Inga Peter, MD NIH/NHLBI the IMMEDIATE Trial Cubist Pharmaceuticals Inappropriate Therapy Systematic Reviews Gowri Raman, PhD AHRQ via Brown U Renal Artery Stenosis Update Angie Mae Rodday, MS PhRMA Foundation Predoctoral Fellowship in Health Outcomes Aging, comorbid conditions, and health care utilization in NIH/NIMH via Brown U persons with HIV William Rogers, PhD Health Literacy Explanatory Models and Medication Adherence NIH via Brown U in HIV Disease AHRQ Postdoctoral Training Grant in Health Services Research Harry Selker, MD, MSPH PCORI NIH/NCCATS Clinical and Translational Science Award

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Honors and Awards

David Adler, MD Professional Society Committee Assignments and Leadership: »» Chair Publications Board, Group for Advancement of Psychiatry Honors and Awards: »» 2010-2014 – Best Doctors in America »» 2010-2014 – Best of Boston Physicians, Boston Magazine »

Ethan Balk, MD, MPH » INSTITUTE FOR Editorships: »» Editorial Board, Comparative Effectiveness Reviews National Panels: »» National Guidelines Clearinghouse CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL James Chambers, PhD, MPharm, MSc Professional Society Committee Assignments and Leadership: »» Research Review Committee Co-Chair, International Society for Pharmacoeconomics and Outcomes Research New Grant Funding: »» Industry Funding for various projects from Bayer, Biogen, Genentech, Pfizer, and MDMA totaling $519,106 Invited Lectures & Presentations: »» A Delicate Balance: How Can We Rightsize Treatment Costs? TedMed Great Challenges Live Event. December 11th, 2014. Recording available here: http://www.tedmed.com/greatchallenges/liveevent/499614

Karen Freund, MD Professional Society Committee Assignments and Leadership: »» Member, Agency for Healthcare Research and Quality (AHRQ), Health Care Research Training (HCRT) Study Section Editorships: »» Editorial Board, Cancer Epidemiology, Biomarkers and Prevention New Grant Funding »» NIH Funding “Insurance Instability and Disparities in Chronic Disease Outcomes”, $1,686,021 »» Ohio State Subcontract, “Cancer Center Support Grant”, $23,925

Richard Hermann, MD, MS Editorships: »» Associate Editor, BMC Health Services Research 2012-present National Panels: »» Member, National Committee for Quality Assurance (NCQA): Behavioral Health Measurement Advisory Panel

David Kent, MD Professional Society Committee Assignments and Leadership: »» Invited Abstract Reviewer, Health Services, Quality Improvement, and Patient-Centered Outcomes Category, International Stroke Conference 2015 »» Comparative Effectiveness Research, Methods Committee, Society of Clinical and Translational Science National Panels: »» Ad Hoc Member, National Institute of Neurological Disorders and Stroke Special Emphasis Panel, National Institute of Neurological Disorders and Stroke PD Planning Grant Review, December 10, 2014 (ZNS1 SRB-J-08) »» Scientific Advisory Board, Ware Working Group on Neurodegenerative Disease Ethics and Policy, University of Pennsylvania »» External Advisor, Patient Centered Outcomes Research Institute (PCORI) Methodology Committee Workgroup on Heterogeneity of Treatment Effect

129 Invited Lectures & Presentations: »» “Why Risk Based Subgroup Analysis Should be Routine.” Society for Clinical Trials (SCT) 35th Annual Meeting. Philadelphia, PA, USA. May 18-21, 2014. »» “Variation in individual treatment effects from repeated period cross-over and multi-person N-of-1 studies.” International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 19th Annual International Meeting. May 34 – June 4, 2014. Montreal, Canada. »» “Using Group Data to Treat Individuals: Understanding the Importance of Heterogeneity of Treatment Effects for Clinical Decision- Making.” Tufts CTSI Heterogeneity of Treatment Effects in Clinical Trials Seminar: Lahey Clinic. Burlington, MA. June 4, 2014. »» “Assessing and Reporting Heterogeneity of Treatment Effect in Clinical Trials,” NIH Collaboratory Webinar Grand Rounds, September 12, 2014 Video: https://www.nihcollaboratory.org/Pages/Grand-Rounds-Hub.aspx » » INSTITUTE FOR »» “Treatment Effect Heterogeneity in Clinical Trials: “An evaluation of 13 large clinical trials using individual patient data.” International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual European Congress. November 8-12, 2014. Amsterdam RAI in Amsterdam, The Netherlands. (poster) »» “Risk modeling and heterogeneity of treatment effect.” International Society for Pharmacoeconomics and Outcomes Research

CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL (ISPOR) 17th Annual European Congress. November 8-12, 2014. Amsterdam RAI in Amsterdam, The Netherlands. (workshop) New Grant Awards: »» NIH/NINDS supplement, “A field synopsis of sex in cardiovascular and cerebrovascular disease prediction” $71,000 »» NPC, “Variation in individual treatment effects from repeated period cross-over studies” $150,000 »» PCORI via Brown U, “Evaluating Observational Data Analysis: Confounding Control and Treatment” $521,526

Debra Lerner, MS, PhD Professional Society Committee Assignments and Leadership: »» Scientific Advisory Board, Boeringher Ingelheim, Inc Invited Lectures: »» Biogen Idec. “The Work Limitations Questionnaire (WLQ): Development and Applications,” March 27, 2014 (Cambridge, MA) »» Employee Assistance Roundtable. “Tufts Depression Study Results and Work Limitations Questionnaire (WLQ),” April 28, 2014 (Chicago, IL) »» NEEBC Wellness Program. “Be Well at Work: Employee-Centered Care for Depression,” October 15, 2014 (Waltham, MA) New Grant Awards: »» Janssen, “Caregivers of Individuals Diagnosed with Schizophrenia: Impact on Employment and Unmet Needs”, $80,000 »» UPenn via Veterans Administration “VA R&D Merit Award”, $162,953

Laurel Leslie, MD, MPH Professional Society Committee Assignments and Leadership: »» Secretary/Treasurer, American Board of Pediatrics »» Associate Director, Pediatric Research in Office Settings, American Academy of Pediatrics National Panels: »» Member, Administration on Children and Families: Developing and Implementing State Psychotropic Medication Systems across Child Welfare, Mental Health, and Medicaid »» Member, Institute of Medicine Forum on Promoting Children’s Cognitive, Affective, and Behavioral Health »» Member, National Scientific Panel , California Evidence-Based Clearinghouse for Child Welfare, San Diego, CA »» Member, Institute of Medicine, Forum on Promoting Children's Cognitive, Affective, and Behavioral Health, Washington DC Invited Lectures & Presentations: »» “Quality improvement applications to tertiary integration. New England Quality Care Alliance. Norwood, MA. April 2014. »» “Why do we use medications for young children in the CWS population: Reflections from psychiatry and pediatrics.” Annual San Diego International Conference on Child & Family Maltreatment. San Diego, CA, January 2014. »» “Community engagement in comparative effectiveness research.” Translational Science 2014. Washington, DC, April 2014. »» “Research capacity-building in diverse communities.” Baystate Medical Center. Springfield, MA, May 2014.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 »» “Community and stakeholder engagement in PBRNs.” Pediatric Clinical Research Networks Special Interest Group. Pediatric Academic Societies Annual Meeting. Vancouver, BC, May 2014.

Pei Jung Lin, PhD New Grant Awards: »» Nationwide Frequency and Costs of Preventable , Alzheimer’s Foundation, $49,921 »» Healthcare Utilization, expenditures, and quality of care, Boston Area Diabetes Research Center $210,000

Peter Neumann, ScD » »

Journal Editorships: INSTITUTE FOR »» Editorial advisory panel, Expert Reviews in Pharmacoeconomics and Outcomes Research »» Editorial board, Health Affairs »» Editorial board, Value in Health CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL National Panels: »» Co-Chair, Panel on Cost-Effectiveness in Health and Medicare »» Robert Wood Johnson Foundation Health Policy Fellows Advisory Board

New Grant Funding: »» Industry Funded Projects from Abbott, Amgen, Biogen, and NPC totaling $367,250 »» Centers for Disease Control $39,324

Susan Parsons, MD, MRP Invited Lectures: »» Improving Health in an Urban Asian Population: Patient Navigation for Patients of Chinese Origin with Newly Diagnosed Breast Cancer. Avon Foundation for Women Biennial Breast Cancer Forum (Invited Plenary Speaker). »» Predictors of overweight and obesity in survivors of childhood cancer. American Institute for Cancer Research Annual Research Conference on Food, Nutrition, Physical Activity, and Cancer (Invited Speaker).

National Panels: »» NIH Population Science and Epidemiology Integrated Review Group, Cardiovascular and Sleep Epidemiology Study Section »» American Cancer Society, Palliative Care and Symptom Management Peer Review Committee – Grant Reviewer »» Professional Society Committee Assignments and Leadership: »» Member, CTSA Consortium Child Health Oversight Committee Pediatric-Adult Lifespan Working Group Awards/Honors: »» Castle Connolly Top Doctor in Pediatric Hematology-Oncology New Grant Funding: »» Avon Foundation $100,000 »» Leukemia and Lymphoma Society “Proof of Paradigm in Cost Effectiveness Analysis with Novel Therapeutics”, $599,936

Gowri Raman, MD, MS New Grant Funding: »» AHRQ via Brown University, “ Renal Artery Stenosis EPC Update”

Angie Mae Rodday, MPH Invited Lectures & Presentations: »» Rodday AM, Paulus JK. Developing a case-based curriculum to teach biostatistics and epidemiology to clinicians. Oral Presentation at the 2014 Annual Joint Statistical Meeting, August 2014, Boston, MA.

131 William Rogers, ScD New Grant Awards »» NIH via Brown University, “Aging, Comorbid Conditions, and Health Care Utilization in Persons with HIV”, $166,022

Harry Selker, MD, MSPH National Panels: »» Agency for Healthcare Research and Quality, National Advisory Council Member »» National Institutes of Health: Directors Pioneer Award Review Committee

» »» Professional Society Committee Assignments and Leadership: » INSTITUTE FOR »» Society for General Internal Medicine Conflict of Interest Committee »» Association for Clinical and Translational Science, Board of Directors, Vice President for Healthcare Implementation, »» Delivery, and Policy Research, Chair, Public Policy Committee »» Clinical Research Forum: Public Policy Committee Chair CLINICAL RESEARCH AND HEALTH POLICY STUDIES POLICY HEALTH AND RESEARCH CLINICAL »» Health Resources in Action: Board of Directors »» Association for Clinical Research Training: Chair, Advocacy Committee Editorships: »» Journal of Investigative Medicine, Associate Editor »» Clinical and Translational Science, Executive Editor Honors and Awards: »» Barry Coller Excellence in Service Award , Association for Clinical and Translational Science New Grant Funding: »» PCORI, “A method for Patient-Centered Enrollment in Comparative Effectiveness Trials: Mathematical Equipoise “, $1,055,452

Norma Terrin, PhD Editorships: »» Statistics Editor, Clinical Infectious Diseases »» Associate Editor, Quality of Life Research »» Editorial Board, Research Synthesis Methods Invited Talks: »» Marginal Structural Models to Estimate the Effect of Food Insecurity on Depression in Injection Drug Users, New England Statistics Symposium, Harvard School of Public Health, Boston, April 2014

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 INSTITUTE FOR MOLECULAR CARDIOLOGY RESEARCH (MCRI) » » Established in 1997, the Molecular Cardiology Research Institute at INSTITUTE FOR Tufts Medical Center is comprised of seventeen principal investigators and physician-scientists working with over seventy staff and trainees.

The MCRI has as its mission the study of molecular mechanisms of human cardiovascular disease; translation of bench (MCRI) RESEARCH CARDIOLOGY MOLECULAR findings to new bedside strategies for diagnosis and therapy; and the mentoring of MD and PhD trainees committed to a career in academic cardiovascular research. The MCRI programmatic areas of focus include vascular biology, cardiomyocyte biology, electrophysiology, human genetics and genomics, immunology, inflammation, molecular pharmacology, signal transduction and transplantation biology. Members of the MCRI work collaboratively with clinical cardiologists and cardiovascular surgeons, biochemists, neuroscientists, pharmacologists, geneticists, immunologists, and epidemiologists to further research in all facets of cardiovascular diseases. Pre-doctoral, graduate, and post-graduate training are high priorities of the Institute, with numerous trainees, including students from the Sackler School of Graduate Biomedical Sciences at Tufts and post-doctoral fellows from all over the world conducting their research in MCRI labs. The MCRI is the home of an NIH-funded Training Program in Cardiovascular Research, which offers nine training positions annually to promising new investigators. In addition, the Institute sponsors a Molecular Medicine Seminar Series throughout the academic year and an Annual MCRI Retreat with nationally and internationally recognized guest speakers participating. The intellectual environment is highly regarded with an outstanding group of investigators. Highlights of 2014

»» Identification of a critical predictor of clinical risk for sudden death and heart disease in the diabetic population

»» Establishment of a novel role of gamma delta T cells in early atherosclerosis

»» Dr. Gordon Huggins named Principal Investigator of the Tufts Medical Center NE Regional Heart Failure Network

»» Dr. Iris Jaffe received a prestigious Established Investigator Award from the American Heart Association

133 Faculty

Name Academic Rank Title and Special Responsibility Executive Director, MCRI Elisa Kent Mendelsohn Chief Scientific Officer, Tufts Medical Center Richard Karas, MD, PhD Professor of Molecular Vice-Chairman of Research, Department of Medicine Cardiology and Medicine Co-Director, Women’s Heart Center Maria Pilar AlcaideAlonso, PhD Assistant Professor »

» Debbie Beasley, PhD Associate Research Professor INSTITUTE FOR Martin Beinborn, MD Assistant Professor Robert Blanton, MD Assistant Professor Assistant Program Director, Cardiology Fellowship Tinatin Chabrashvili, MD, PhD Associate Professor (Neurology)

MOLECULAR CARDIOLOGY RESEARCH (MCRI) RESEARCH CARDIOLOGY MOLECULAR Isabelle Draper, PhD Assistant Professor Jonas Galper, MD, PhD Professor Director, Center for Translational Genomics; Vice-Chair, IRB; Chair, SRC Gordon Huggins, MD Associate Professor Co-Director, MD PhD Program, Tufts University School of Medicine Assistant Research Professor Lakshmanan Iyer, PhD (Neuroscience) Iris Jaffe, MD, PhD Associate Professor Co-Director, MCRC Director, Interventional Research Division of the Surgical Navin Kapur, MD Assistant Professor Research Laboratories Director, Acute Circulatory Support Program Alan Kopin, MD Professor Director, Molecular Pharmacology Research Center Associate Research Professor Janis Lem, PhD Director, Transgenic Core Facility (Ophthalmology) Sami Noujaim, PhD Assistant Professor Ho-Jin Park, PhD Assistant Professor Gavin Schnitzler, PhD Assistant Professor

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Major Clinical Programs The Molecular Cardiology Research Institute has a close relationship with the Division of Cardiology. Six members of the MCRI are active clinicians within the Division of Cardiology and several serve in leadership roles in the Preventive Cardiology Center, Heart Failure and Transplant Program, and the Women’s Heart Center. Please refer to the Division of Cardiology for specific information regarding major clinical programs.

Teaching Activities MCRI Investigators provide extensive mentoring and financial support to students at Tufts University School of »

Medicine and the Sackler School of Graduate Biomedical Sciences. Currently, five graduate students from Tufts are » INSTITUTE FOR mentored by MCRI faculty and many of the MCRI investigators direct and lecture in graduate courses. The clinician- scientists within the MCRI participate in the teaching of medical students through the Patient-Doctor II course and the Integrating Biomedical Research and Clinical Medicine course, as well as teaching students, house officers and clinical cardiology fellows while attending in the ambulatory clinics and the inpatient services. MOLECULAR CARDIOLOGY RESEARCH (MCRI) RESEARCH CARDIOLOGY MOLECULAR Recognized nationally and internationally as a leader in cardiovascular research, the Molecular Cardiology Research Institute is training a new generation of investigators in the state-of-the-art technologies necessary to translate bench findings to the bedside and to develop new diagnostic and therapeutic strategies to fight cardiovascular disease. The MCRI has a robust fellowship program funded in part by a National Institutes of Health T32 training grant with nine training positions. Fellows are engaged in basic, translational and clinical research throughout the Institute and the Cardiology Division.

Graduates of the MCRI fellowship program typically pursue careers in academic medicine (MD graduates) or research departments (PhDs) as independent investigators, with the occasional fellow pursuing an opportunity in industry.

Research Activities Research in the MCRI is funded by the NIH (primarily through the NHLBI), the American Heart Association, the Juvenile Diabetes Research Foundation, private philanthropic foundations and Industry sponsors including pharmaceutical, biotech and medical device companies. The major programs of the Molecular Cardiology Research Institute are described below.

Molecular Cardiology Research Center »» Richard Karas, MD, PhD, Director »» Iris Jaffe, MD, PhD, Co-Director »» Pilar Alcaide Alonso, PhD »» Robert Blanton, MD »» Navin Kapur, MD »» Gavin Schnitzler, PhD

The Molecular Cardiology Research Center, a group of closely aligned laboratories, is the founding group of investigators that formed the MCRI. The six laboratories of the Molecular Cardiology Research Center work closely with one another to explore themes of common interest in heart and blood vessel diseases.

The Karas Laboratory is focused in four primary areas: improving understanding of the effects of estrogen on the cardiovascular system; investigating the extent to which abnormalities of blood vessel function contribute to both atherosclerosis and high blood pressure, examining the importance of low levels of the “good cholesterol” HDL in contributing to heart disease and stroke, and studying the role of protein kinase G (the main effector of nitric oxide) on vascular health. The laboratory studies the molecular pathways within cells of the heart and blood vessels that mediate responses to estrogen. Heart and blood vessel diseases are by far the leading causes of death for women in this country, and patient-based studies have shown that hormone replacement therapies in postmenopausal women can alter the risk of heart and blood vessel diseases. Dr. Karas’ work is aimed at learning more about how estrogen and nitric oxide regulates the development of heart and blood vessel diseases. The laboratory also has an active research program in studying the adverse events that can result from the use of cholesterol altering medications.

135 The Jaffe Laboratory is investigating the role of aldosterone, a hormone that regulates blood pressure, in the development of hardening of the arteries, the blood vessel disease that causes heart attacks. Aldosterone works by entering cells and binding to the mineralocorticoid receptor (MR) resulting in changes in the genes that are turned on in that cell. Human clinical trials of drugs that block aldosterone binding to MR demonstrate that these drugs decrease mortality and prevent heart attacks. However, the mechanism of protection from heart attack by these drugs is not known. The Jaffe laboratory has demonstrated that MR is located in the cells of the human blood vessel and MR controls the pattern of genes turned on in the vessel. The Jaffe Lab recently found that aldosterone promotes hardening of the arteries by activating the immune system resulting in inflamed arteries. In addition, the lab determined that MR in the blood vessel plays a direct role in aging-associated high blood pressure. More recently the lab has become interested in »

» exploring new ways in which the hormone aldosterone might interact with the sex hormone estrogen and also in INSTITUTE FOR determining why woman exposed to pregnancy complications have a much higher risk of heart disease later in life. These studies will continue provide new insights into the causes of common cardiovascular diseases and identify new drug targets for prevention and treatment of heart attacks, strokes, and high blood pressure.

The Alcaide Alonso Laboratory aims to find specific ways to prevent and/or treat inflammation, a condition negatively MOLECULAR CARDIOLOGY RESEARCH (MCRI) RESEARCH CARDIOLOGY MOLECULAR affecting health in a variety of diseases ranging from autoimmune disease to cardiovascular disease. Inflammation is in part mediated by infiltration of immune cells such us T cells into tissues and organs. The lab's research studies combine in vitro and in vivo vascular immunology and cardiac physiology approaches to identify basic mechanisms that mediate T cell infiltration in tissues, with a focus on the heart in the context of heart failure. A better understanding of these basic mechanisms may result in the development of new therapeutic interventions that target T cell infiltration in the heart as a way to reduce inflammation and potentially heart failure, a syndrome affecting nearly 25 million people worldwide.

The Blanton Laboratory seeks to understand how the heart protects itself from a process called “pathologic cardiac hypertrophy”. Pathologic hypertrophy commonly occurs in patients’ hearts with medical conditions like hypertension, heart valve disease (such as aortic stenosis), and myocardial infarction, and it often leads to congestive heart failure. The laboratory is studying how pathologic hypertrophy develops in order to determine which molecules in the heart help prevent pathologic remodeling. These molecules may turn out to be good targets to try to target with drugs. The laboratory discovered that a protein called “PKGIα” helps keep the heart from developing pathologic hypertrophy. Now it is using animal models to try to identify how PKGIα protects the heart from pathologic hypertrophy, in particular, with which other molecules in the heart PKGIα cooperates to determine if these other molecules may serve as new drug targets.

The Kapur Laboratory’s translational research focuses on large animal models of acute and chronic heart failure, circulatory support device development, and cardioprotective mechanisms in the setting of acute myocardial infarction. The laboratory’s basic research focuses on molecular mechanisms governing maladaptive cardiac remodeling in heart failure, in particular, In signaling via the transforming growth factor beta (TGFb) system. Over the past 6 years, the laboratory has published several key papers focused on a TGFb co-receptor known as endoglin and was the first to establish that reduced endoglin activity improves survival and limits maladaptive cardiac remodeling in heart failure. More recently, the laboratory has demonstrated that targeting endoglin using an antibody-mediated approach not only limits the development of cardiac fibrosis, but can reverse established cardiac fibrosis in preclinical models of heart failure.

The Schnitzler Laboratory is studying the roles of chromatin changes in the regulation of transcription by nuclear hormone receptors, including estrogen receptor and glucocorticoid receptor. The laboratory uses a combination of standard and high-throughput techniques to understand how the genetic and epigenetic factors that modulate chromatin structure give rise to tissue-specific transcriptional responses to glucocorticoids or estrogen.

Laboratory of Vascular Myocyte Biology

Debbie Beasley, PhD The Beasley Laboratory seeks to understand the early events that promote arterial inflammation, the predecessor of vascular diseases that can lead to heart attack or stroke. There has been an explosion in recent years in the understanding of “innate immunity” (i.e. immunity that is present at birth). Notably, cells of the immune system have been shown to express various members of a family of receptors (Toll-like receptors) that sense unique molecular patterns associated with viruses, bacteria and other microorganisms, and thereby notify host cells about the presence of microorganisms, and elicit an immune response. The laboratory is testing the novel idea that a specific type of white blood cell that is normally involved in fighting infections and not previously suspected of promoting atherosclerosis,

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 leads to early atherosclerotic lesions. The results will provide new avenues for treating and/or preventing vascular disease by modulating these specific immune responses. Further, the laboratory is studying whether intestinal bacteria influences the progression of vascular disease in mouse models via mechanisms that involve a novel immune cell type. The results may provide new avenues for treating or preventing vascular disease by modulating intestinal bacteria.

Neurovascular Laboratory

Tinatin Chabrashvili, MD, PhD Dr. Chabrashvili is a clinician-scientist in the Department of Neurology who specializes in movement disorders. The Chabrashvili laboratory is located in the MCRI and studies cerebral microvascular inflammation and blood-brain » » barrier permeability. INSTITUTE FOR

Laboratory of Lipid Metabolism and Cardiovascular Signaling

Jonas Galper, MD, PhD

Ho-Jin Park, PhD (MCRI) RESEARCH CARDIOLOGY MOLECULAR Autonomic neuropathy is a major complication of diabetes and has been associated with a marked increase in the incidence of sudden death in the diabetic population. The Galper Laboratory has demonstrated a new relationship between the development of this complication of diabetes and the regulation of cholesterol. The laboratory has identified several new candidate molecules that might be involved in this process and might serve as new targets in the treatment and prevention of this complication of diabetes and the associated abnormal heart beats and sudden death.

Abdominal aortic aneurysm is a disease that affects more than 10% of men above the age 65. Currently, its life threatening complications can only be treated surgically. Using a mouse model for this disease, the Galper Laboratory has data which suggest that a new drug that was developed for the treatment of life threatening infections might be used to decrease the incidence and severity of aneurysms. The laboratory is also testing the possibility that a low dose of a drug that causes inflammation might actually protect the aorta from the development of this disease. These experiments may support the use of these agents as a kind of immunization against this devastating disease.

Recently the Galper laboratory has extended its work on abnormal heart rhythm to similar mechanisms that might lead to death of nerve cells that cause Parkinson’s disease. A protein that is in excess in the diabetic mouse and in the diabetic patient is also in excess in Parkinson’s disease. The lab has established data supporting the conclusion that this excess protein may be involved in accelerating the death of nerve cells in the brain that cause Parkinson’s disease.

Center for Translational Genomics

Gordon Huggins, MD Research in the MCRI Center for Translational Genomics (CTG) is focused on understanding how genetic factors contribute to diseases involving the heart muscle, heart valves as well as risk factors for heart diseases including obesity and adult-onset diabetes. The goals of the CTG include identifying disease-causing genes and mutations, developing diagnostic and prognostic markers and drug targets, and creating new therapeutic strategies for those most likely to develop disease. Through a predictive and personalized approach, treatments can be tailored for those predisposed to disease based upon the anticipated severity of the disease. The Center is currently studying the genetics of common diseases such as hypertension and obesity, as well as hypertrophic cardiomyopathy (an abnormal enlargement of the heart that can cause heart failure and sudden death), bicuspid aortic valve and aortic aneurysm.

Molecular Pharmacology Research Center

Alan Kopin, MD, Director Martin Beinborn, MD Isabelle Draper, PhD The Kopin Laboratory studies G protein-coupled receptors (GPCRs), a family of more than 300 proteins which modulate a wide variety of physiological functions. These receptors are among the most important targets for drug discovery. The laboratory is developing tools to modulate selected receptors (e.g. CCR6) which play an important role in causing inflammation (e.g. atherosclerosis, asthma). The modulators that are generated will provide novel tools to enable better

137 understanding of disease mechanisms as well as provide a first step toward developing a new class of therapeutics. The lab also studies how genetic variation in GPCRs influences receptor and/or drug activity. These investigations may provide hints regarding the role of receptors in health and in disease as well as preview how inter-individual differences may alter drug response. The Kopin Laboratory is also investigating a subset of GPCRs which are both unique to insects (vs. mammals) and which modulate functions critical for insect survival. These receptors provide promising insecticide targets. Screening for corresponding compounds is part of the ongoing effort in the lab.

The Beinborn Laboratory focuses primarily on receptors that are relevant for the treatment of diabetes, obesity, and bone disease. Recently, the lab's efforts have helped to launch approaches for discovering two new types of diabetes drugs that hold the promise of being superior to currently available medications. A major drug screening program in » » INSTITUTE FOR collaboration with the National Institutes of Health based on some of these findings is currently underway. In a second initiative, also in collaboration with the NIH, the lab has begun to identify novel blockers of the parathyroid hormone receptor. Such compounds are anticipated to be useful for the treatment of a rare form of hereditary bone disease, but may also provide future therapies for much more prevalent conditions including life-threatening forms of hypercalcemia and the formation of cancer metastases in the bone. MOLECULAR CARDIOLOGY RESEARCH (MCRI) RESEARCH CARDIOLOGY MOLECULAR The Draper Laboratory is a Drosophila laboratory which focuses on expediting the characterization of genes relevant to human physiology. Dr. Draper pioneered the introduction of mammalian genes in the fly system as a means to expedite the exploration of conserved protein function in vivo. Her current research focuses on the investigation of muscle physiology and disease, motor function and RNA processing. Collaborative efforts led to the establishment of a research pipeline, enabling rapid translation of findings from Drosophila melanogaster to human myoblast cell lines (healthy, diseased; differentiated from primary cultures or from iPSCs). Conversely, the functional characterization of novel modifiers of muscle disease that are identified in mammalian systems can be expedited in the Drosophila model organism. Using proprietary technology in conjunction with this multisystem approach the Draper Laboratory is assessing the effects of candidate drugs as potential therapeutics for human muscle/heart disease.

Noujaim Research Laboratory

Sami Noujaim, PhD Dr. Noujaim’s research focuses on the study of cardiac fibrillation mechanisms. Specifically, he is interested in the role that inward rectifiers play in atrial fibrillation (AF). AF is the most common heart rhythm disturbance, and a major cause of morbidity and mortality. Pharmacological treatment of AF is inadequate. This is in part due to the relatively poor understanding of AF mechanisms and of the structural and molecular bases of drug-ion channel interactions. The Noujaim laboratory uses technological, and conceptual advances from the fields of structural biology and ion channel trafficking in order to explore the electrophysiological details of the contribution of inward rectifiers, and specifically the acetylcholine sensitive potassium current (IKACh) to arrhythmogenesis in the atria. The laboratory also studies functional and trafficking aspects of drug-ion channels interactions. Atrial fibrillation (AF) is the most common heart rhythm disturbance.

Retina Research Laboratory

Janis Lem, PhD Opsin mutations cause ~25% of blinding dominant retinal degenerations. Twenty-two years after the identification of the first rhodopsin mutation, effective therapies to slow or prevent degeneration have yet to be developed, most likely because the mechanism of degeneration differs for the 75+ different rhodopsin mutations. The Lem laboratory has identified a subset of opsin mutants that share properties that suggest they have a shared mechanism of degeneration and, hence, a shared therapy. This could lead to development of diagnostic methods to identify other rhodopsin mutants that fall in this subclass and identify the population of patients that will respond well to approaches that are specific to this mechanism of degeneration.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Research Support

In 2014, the Institute engaged in the following funded research projects:

PI Funding Source Title of Project Endothelial regulation of IL17 producing T effector cell NIH migration T Cell Mediated Immune Responses as a Regulator of Heart Pilar Alcaide Alonso NIH Failure The Role of Inflammation and Leukocyte Recruitment in American Heart Association Heart Failure Aldosterone Regulation of Transendothelial Migration: A Pilar Alcaide Alonso/Iris Jaffe Tufts University Potential Novel Target for Heart Attack Prevention Kathleen Barrett American Heart Association Pre-Doctoral Fellowship Debbie Beasley NIH Atherogenic role of T cell modulation by intestinal bacteria Development of a Novel Screen for Inhibitors of PTH Martin Beinborn NIH Receptor-Mediated Signaling Cardiac Myocycte-Role of PKG I Alpha in Aging-Dependent NIH Robert Blanton Cardiac Remodeling American College of Cardiology GEMSTAR Matching Grant Jamie Doyle Charles A. King Trust Generation of Novel Probes to Explore the Role of MRGPRS Isabelle Draper U of Florida Gene Discovery in Muscular Dystrophy Sudden Death in Type 1 Diabetes: A Mouse Model for Dead Juvenile Diabetes Research Foundation Jonas Galper in Bed Syndrome NIH Role of Sterols and Insulin in Cardiac Autonomic Response JT Babbitt Foundation Genes that Modify Hypertrophic Cardiomyopathy Miriam Hospital Gene and Behavioral Effects on High-Density Lipoprotein Gordon Huggins Miriam Hospital GENE X Behavior Interaction in the LOOK AHEAD Study Miriam Hospital Gene X Environmental Interaction in Diabetic Nephropathy NIH Basic Mechanisms of Human Calcific Aortic Valve Disease The Role of Smooth Muscle Cell Mineralocorticoid American Heart Association Receptors American Heart Association Extra-Renal Mineralocorticoid Receptors in Hypertension Iris Jaffe The Role of Vascular MR-Regulated Genes in Vascular NIH Function and Disease Smooth Muscle Mineralocorticoid Receptors in Vascular NIH Aging and Hypertension Acute and Sustained Cardiac and Vascular Effects of Iris Jaffe/Robert Blanton Novartis Serelaxin in the Angiotensin II/L-NAME Heart Failure Model A new animal model for the study of the mechanism of Hongwei Jin American Heart Association ventricular arrhythmias in type I diabetes

139 PI Funding Source Title of Project Abiomed Impella CP: Door to Unload Study Cardiac Assist TandemHeart RV Phase One Preclinical Study Mechanical Pre-Load Reduction via Vena-Caval Occlusion MD Start for Decompensated Heart Failure Navin Kapur Maquet Clinical Hemodynamic Study of MEGA-IABP Function Cardiac Fibrosis in Progressive Heart Failure: NIH The Role of Endoglin » » INSTITUTE FOR Endoglin: A Novel Therapeutic Target for Fibro- Tracon Pharmaceuticals proliferative Diseases The Role of PKG-1a in cGMP Signaling Mechanisms through Merck the Evaluation of the Effects of cGMP Modulations in Richard Karas/Robert Blanton Normal and Disease Studies in the PKG1-LZM Mouse MOLECULAR CARDIOLOGY RESEARCH (MCRI) RESEARCH CARDIOLOGY MOLECULAR Merck TAC LKR140269 NIH Vascular Surgery - Estrogen and the Injury Response Richard Karas NIH Training Program in Cardiovascular Research Bursicon Receptor Antagonists: Templates for Developing Alan Kopin NIH Novel Insecticides Transient Receptor Potential Channel Transcriptional Profile Kevin Morine Heart Failure Society of America in Advanced Heart Failure Structural and molecular basis of drug-induced Sami Noujaim NIH IKACh reduction Yali Zhang Tufts University Zucker Award

Honors and Awards

Pilar Alcaide, PhD »» Abstract entitled “T Cell Mediated Immune Responses Regulate Cardiac Remodeling and Survival in Pressure Overload Induced Heart Failure” selected as Best of AHA specialty conferences, Basic Cardiovascular Sciences annual meeting July 2014

Robert Blanton, MD »» Received award for top 10% of abstracts at AHA Basic Cardiovascular Sciences Meeting. Abstract entitled “Identification of Novel Protein Kinase G I Alpha Antiremodeling Substrates in the Myocardium”

Iris Jaffe, MD, PhD »» Recipient, Established Investigator Award, American Heart Association »» Recipient, AHA High Blood Pressure Research Council Mid-Career Award for Research Excellence

Navin Kapur, MD »» Named Director, Acute Circulatory Support Program; Tufts Medical Center »» Elected Member, Program Planning Committee, American College of Cardiology »» Named to the Editorial Board: Frontiers in Cardiac Electrophysiology

Sami Noujaim, PhD »» Named to the Editorial Board: Frontiers in Cardiac Electrophysiology

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 INSTITUTE FOR MOLECULAR ONCOLOGY RESEARCH (MORI) » » INSTITUTE FOR The Molecular Oncology Research Institute (MORI), a core component of the Tufts Medical Center Cancer Center, has 17 faculty members and occupies over 44,000 square feet in the 75 Kneeland Street MOLECULAR ONCOLOGY RESEARCH (MORI) RESEARCH ONCOLOGY MOLECULAR research building. Its mission is to explore the molecular mechanisms of neoplastic transformation and to promote the translation of basic research findings into the clinic. To achieve this goal, MORI scientists carry out research that spans the spectrum from gene discovery to target validation for drug development. MORI functions independently of the Department of Medicine and reports to a Board of Advisors comprised of senior Tufts Medical Cente and TUSM executives and the Chairman of the Department of Medicine. Highlights of 2014

»» Institute investigators gave 30 Invited Lectures

»» MORI faculty produced 55 publications

»» Faculty received 7 new research awards totaling $1.23M

141 Faculty

Name Academic Rank Executive Director, MORI Philip Tsichlis, MD Jane F. Desforges Professor Anika Agarwal, MD, MPhil Assistant Professor Rachel Buchsbaum, MD Associate Professor Alain Charest, PhD Associate Professor » » INSTITUTE FOR Lidija Covic, PhD Assistant Professor Keyong Du, PhD Assistant Professor Andrew Evens, DO Professor

MOLECULAR ONCOLOGY RESEARCH (MORI) RESEARCH ONCOLOGY MOLECULAR Mark Ewen, PhD Associate Professor Ole Gjoerup, PhD Assistant Professor Philip Hinds, PhD Professor Guo-fu Hu, PhD Associate Professor Miaofen Hu, PhD Assistant Professor Athan Kuliopulos, MD, PhD Professor Charlotte Kuperwasser, PhD Associate Professor Paul Mathew, MD Associate Professor Elizabeth McNiel, DVM, PhD Assistant Professor James Yoo, MD Assistant Professor

Teaching Activities Seminars The Institute has a biweekly seminar program for intramural research at MORI at which graduate students and postdoctoral fellows present their work.

MORI holds a monthly faculty seminar program where principal investigators present their work to the MORI faculty. These seminars encourage the sharing of ideas and prompt collaborations between laboratories.

The Institute sponsors a campus-wide seminar series in which invited speakers from other institutions present their research to Tufts MC and TUSM faculty. These seminars encourage the sharing of ideas and foster collaborations between laboratories.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Research Activities Research Support In 2014, the Institute received new, peer-reviewed research awards in the amount of $1.23 million.

PI Funding Source Title of Project Finding the X Factor: how breast cancers conscript the tumor Rachel Buchsbaum, MD Tufts CTSI microenvironment Development of PAR2 Inhibitors for the Treatment of Lidija Covic, PhD NIH »

Nonalcoholic steatohepatitis (NASH) » INSTITUTE FOR EMR Adverse Drug Event Detection for Pharmacovigilance Andrew Evens, D.O., MS NIH (subcontract) Miaofen Hu, MD, PhD Tufts CTSI The role of Cdk6 in Adipogenesis, Obesity, and Diabetes Understanding the link between cellular reprogramming and BCRF early pre-malignant changes in human breast epithelial cells (MORI) RESEARCH ONCOLOGY MOLECULAR Charlotte Kuperwasser, PhD (continuation) Mechanisms of Breast Cancer Associated with Obesity – NIH/NCI supplement Elizabeth McNiel, DVM Animal Cancer Foundation EZH2: A new target for canine bladder cancer

Honors and Awards

Dr. Rachel Buchsbaum Invited lectures: »» Invited speaker, AACR Meeting, April 2014. Tiam1 and the Breast Cancer Microenvironment Honors and Awards: »» Tufts University School of Medicine Outstanding Lecturer »» Tufts University School of Medicine Accomplished Teaching

Dr. Andrew Evens Invited Lectures: »» Center of Cancer Systems Biology (CCSB) Grand Rounds. Translational Analyses of Novel Targeted Agents for the Treatment of Lymphoma (Sponsor: GeneSys Research Institute (GRI)). Boston, MA; January 7th, 2014. »» 2014 Highlights of ASH in North America. Topic: Hodgkin Lymphoma (Sponsor: ASH). Atlanta, GA; January 25th, 2014. »» 2014 Highlights of ASH in North America. Topic: Hodgkin Lymphoma (Sponsor: ASH). Seattle, WA; February 1st, 2014. »» Lymphoma Research Foundation (LRF) Mentoring Program. Grant opportunities and funding mechanisms for clinical investigators in the field of lymphoma (Sponsor: LRF). Scottsdale, AZ; February 7th, 2014. »» St. Luke’s Hospital Oncology Grand Rounds. The Prognosis and Treatment of Hodgkin Lymphoma: Long Term Considerations (i.e., Survivorship). New Bedford, MA; February 19th, 2014. »» Aggressive Non-Hodgkin Lymphoma; New England Lymphoma Workshop (Patient Forum); March 22nd, 2014. »» 2014 Highlights of ASH in Asia. Topic: Hodgkin Lymphoma (Sponsor: ASH). Singapore, Asia; March 29th and 30th, 2014. »» Controversial Cases in Hematologic Malignancies and Hematology 2014. Topic: Prognosis and Treatment of Peripheral T-cell Lymphoma (Sponsor: Massachusetts General Hospital). Boston, MA; April 12th, 2014. »» Peripheral T-Cell Lymphomas: Contemporary Prognostic and Therapeutic Approaches. Oncology Grand Rounds; Lahey Clinic. Burlington, MA; May 29th, 2014. »» Arterial Disease, Second Cancers, and Other Aftermath in Hodgkin Lymphoma; Lowell General Hospital Grand Rounds; Lowell, MA, June 11th, 2014. »» Hodgkin Lymphoma in Older (Elderly) Patients, Pathology Working Group and the Subtypes Initiative, Roundtable discussion on the state-of-the-art pathology and future initiatives; INTERLYMPH 2014 Annual Meeting. UCLA, Los Angeles, CA, June 18th, 2014. »» Impact of Lifestyle on Lymphoma Histology and Genetics, Lifestyles and Environment Working Group INTERLYMPH 2014 Annual Meeting. UCLA, Los Angeles, CA, June 19th, 2014. 143 »» The Prognosis and Treatment of Hodgkin Lymphoma: Past, Present, and Future Directions, Lymphoma/Myeloma Hematology Grand Rounds, MD Anderson Cancer Center; Houston, TX; August 16th, 2014. »» Antibody Drug Conjugates in Lymphoma, New Therapeutic Advances in Hematologic Malignancies/Diseases; Burlington, MA; October 23rd, 2014. Honors and Awards: »» 2014 Scientific Advisory Board (SAB), Lymphoma Research Foundation (LRF)

Dr. Philip Hinds Invited Lectures: » »

INSTITUTE FOR »» 2014 National Health Research Institutes, Taipei, Taiwan »» 2014 Department of Pharmacology, Rush University

Dr. Athan Kuliopulos Invited Lectures: MOLECULAR ONCOLOGY RESEARCH (MORI) RESEARCH ONCOLOGY MOLECULAR »» Delivered Webinar for the NHLBI SMARTT Program 5 year renewal: “Overcoming Barriers to Early Translation in Therapeutics Development: Development of PZ-128 for the Prevention of Arterial Thrombosis in Acute Coronary Syndromes and Percutaneous Coronary Intervention, May 28, 2014. »» Chemistry Department, UC Santa Cruz, CA; Medicinal Chemistry and Drug Development with Cell-penetrating Pepducins, July 25, 2014 »» Discovery on Target; Membrane Protein Targets, 2014, ITargeting Receptors wit Cell Penetrating Pepducins; From Bench to Bedside, Boston, MA October 10, 2014 »» Boston Angiogenesis Meeting, IMatrix Metalloprotease Signaling in Tumor Angiogenesis, Boston, MA, November 12, 2014 Honors and Awards: »» Elected member of NIH/NHLBI Scientific Review Board SMARTT Program

Dr. Paul Mathew Honors and Awards: »» Boston Magazine Best Doctors 2014

Dr. Elizabeth McNiel Honors and Awards: »» 2014 Comparative Oncology Award, Animal Cancer Foundation

Dr. Philip Tsichlis Invited Lectures »» March 25, 2014: Invited presentation at Astrazeneca in Waltham, MA »» April 6, 2014: AACR Meeting, San Diego, CA; Chaired and presented a lecture in the session on “Modulation of Micro RNA Expression” »» April 22, 2014: Invited presentation at ArQule, a biotechnology company in Boston, MA »» May 22, 2014: Invited presentation in the Clinical Immunology Lecture Series at the Beth Israel-Deaconess, Boston, MA »» October 2014: European meeting on Inflammation and Cancer. “Akt and Regulatory Tcells” Honors and Awards »» “Taxiarchis of Phoenix” Medal awarded by the President of the Hellenic Republic for major contributions to science, the arts, culture and society (2014). »» Honorary degree, University of Crete, (2014).

Dr. James Yoo Honors and Awards »» 2011-2014 Chair, ASCRS Awards Committee

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 PUBLICATIONS

145 Abstracts, letters to editor and presentations excluded from listings. Division of Cardiology 1. Bader Y, Link M, Estes NAM. The Athlete’s Electrocardiogram in Shenasa M, Josephson ME, Estes NAM ECG Handbook of Contemporary Cardiotext, Minneapolis, MN (2014). 2. Barrett Mueller K, Lu Q, Mohammed NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. Estrogen receptor inhibits mineralcortocoid receptor transcriptional regulatory function. Endocrinology. 2014; 155(11):4461-4472. PMID: 25051445. 3. Bene NC, Alcaide P, Wortis HH, Jaffe IZ. Mineralcortocoid Receptors in Immune Cells; Emerging Role in »

» Cardiovascular Disease. Steroids, 2014 April 21 pii: S0039-128Z(14)00076-2. Doi:10.1016/j. PMCID: PMC4205205. PUBLICATIONS 4. Blankstein R, Rowin EJ. What is the best imaging test for patients with hypertrophic cardiomyopathy? It depends on the clinical question! J Cardiovasc comput Tomogr. 2014 Nov-Dec;8(6):438-41. 5. Boumil MM and Salem DN. In…and out: open access publishing in scientific journals. Quality Management in Health Care 23(3):133-7, 2014. 6. Caselli S, Maron M, Urbano-Moral, Pandian NG, Maron B, Pellicca A. Differentiating left ventricular hypertrophy in athletes from that in patients with hypertrophic cardiomyopathy. Am J Cardiol 2014; 114:1383-1389. 7. Caselli S, Montesanti D, Aurore C, Di Paolo D, Pisicchio C, Squeo MR, Musumeci B, Spataro A, Pandian NG, Pelliccia A. Patterns of left ventricular strain and strain-rate in Olympic athletes. J Am Soc Echocardiogr. 2014 Nov 20. pii: S0894-7317(14)00752-4, doi: 10.1016/J.echo.2014.10.010. 8. Chan RH, Maron BJ, Olivotto I, Assenza G, Lesser JR, Haas T, Gruner C, Crean A, Rakowski H, Udelson JE, Rowin E, Tomberli B, Spirito P, Formisano F, Biagini E, Rapezzi C, De Cecco CN, Autore C, Cook EF, Hong SN, Gibson CM, Manning WJ, Appelbaum E, Maron MS. Prognostic Utility of Contrast-Enhanced Cardiovascular Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy: An International Multicenter Study. Circulation 2014:130:484-95. 9. Chen CW, Jaffe IZ, and Karumanchi SA. Preeclampsia and Cardiovascular Disease. Cardiovasc Res, 2014:101(4):579-86. PMID: PMC3941598. 10. Dohadwala M, Link MS. Implantable defibrillators in Long QT Syndrome, Brugada Syndrome, Hypertrophic Cardiomyopathy, and Arrhythmogenic Right Ventricular Cardiomyopathy. Cardiology Clinics-Pacemakers and Implantable Cardioverter Defibrillators, edited by Theofanie Mela, 2014; 305-318. 11. Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, Patel MR, Picard MH, Udelson JE, Velasquez EJ, Cooper L; PROMISE investigators. PROspective Multicenter Imaging Study for Evaluation of chest pain: Rational and design of the PROMISE trial. Am Heart J. 2014:167:796-803. 12. DuPont JJ, Hill MA, Bender SB, Jaisser F, and Jaffe IZ. Aldosterone and Mineralocortocoid Receptors: Regulators of Ion Channels Beyond the Kidney. Hypertension, 2014:63(4):632-7. PMCID: PMC3954941. 13. Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Yang Y, Selker HR, Huggins GS, Cupples LA, Peter I. Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trail. The pharmacogenomics journal 2014. 14. Esposito M, Shah NN, Korabathina R, Pan C, Paruchuri V, Finley J, Shah A, Boyle A, Vaillant R, Kimmelstiel CD, Kapur NK. Quantitative assessment of myocardial perfusion using time-density curve analysis after elective percutaneous coronary intervention. J Invasiv Cardiol. 2014 Feb;26(2):60-3. PubMed PMID: 24486662. 15. Estes NA. Controversies in Cardiovascular Medicine Revisited Circulation. 2014 Oct 28;130(18):1561.doi:10.1161/ CIRCULATIONAHA.114.013338.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 16. Estes Nam. Examining Achilles Heel: Improving responses t CRT Therapy J Am Coll Cardiol Img. 2014;7(12) 1249-1250. 17. Estes NA 3rd. Is it Time for a New Approach to Implantable Cardioverter-Defibrillator Replacement? J Am Coll Cardiol. 2014 Jun 10,63(22):22395-7. 18. Faletra F, Pedrazzini G, Pasotti E, Pandian NG. Mitral insufficiency, Book Chapter in book, Echocardiography in Mitral Valve Disease Editor: Francesco Faletra. 2014 Publ: Springer(In Press). 19. Faletra FF, Ramamurthi A, Dequarti MC, Leo LA, Moccetti T, Pandian NG. Artifacts in three-dimensional

echocardiography. J Am Soc Echocardiogr 2014:27:453-62. » » PUBLICATIONS 20. Fleming LM. Subspecialis Scholarship In Quality Improvement (2014) JACC.64(10):1064-5. 21. Fleming LM, Gavin M, Piatkowski G, Chang J, Mukamal K. Derivation and Validation of a 30-day Heart Failure Readmission Model (2014) American Journal of Cardiology. In Press. 22. Fleming LM, Kociol R. Interventions for Heart Failure Readmissions: Successes and Failures. (2014) Current Heart Failure Reports. Epub March 1, 2014. 23. Fleming LM, Manning WJ. Extracardiac Findings on Echocardiography: Blissful Ignorance or a Call to Improve our Training? (2014) J Am Soc Echocardiography. 27(5):547-8. 24. Fogel R, Epstein AE, Estes NAM, Lindsay BD, Kremers MS, Kapa S, Brindis R, and Russo AE. The disconnect between the guidelines, the appropriate use criteria, and reimbursement coverage decisions: the ultimate dilemma. J Am Coll Cardiol. 2014 Jan 7;63(1):12-14. 25. Galmiche G, Pizard A, Gueret A, El Moghrabi S, Berger S, Labat C, Jaffe IZ, Lacolley P, and Jaisser F. Smooth Muscle Cell Mineralocorticoid Receptors are Mandatory for Aldosterone-salt to Induce Vascular Stiffness. Hypertension. 2014; 63(3):520-526. PMID:24296280. 26. Goldenberg I, Kutyifa V, Klein HU, Cannom DS, Brown MW, Dan A, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Kautzner J, Klempfner R, Kuniss M, Merkely B, Pfeffer MA, Quesada A, Viskin S, McNitt S, Polonsky B, Ghanem A, Solomon SD, Wilber D, Areba W, Moss AJ. Survival with cardiac-resynchronization therapy in mild heart failure. N Engl J Med. 2014 May 1;370(18):1694-70. 27. Gruner C, Chan RH, Crean A, Rakowski H, Rowin EJ, Care M, Deva D, Williams L, Appelbaum E, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Siminovitch K, Ralph-Edwards AS, Rastegar H, Maron BJ, Maron MS. Significance of left ventricular apical-basal muscle bundle identified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Eur Heart J 2014 Oct; 35(39):2706-13. 28. Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, and Lely AT. Hydrogen Sulfide Attenuates SFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor. J Am Soc. Nephrol. 2014; 25(4):717-725. PMCID:PMC3968492. 29. Jaffe IZ, Jaisser F. Endothelial Mineralocorticoid Receptors: turning cardiovascular risk factors into cardiovascular dysfunction. Invited Editorial. Hypertension, 2014;63(5):915-917. PMCID: PMC3984296. 30. Javed A, Jumean M, Murad MH, et al. Dignostic performance of body mass index to identify obesity as defined by body adiposity in children and adolescents: a systematic review and meta-analysis. Pediatr Obes. 2014 Jun 25. 31. Jumean MF, Kiernan MS. Determinants of survival following hospitalization for acute heart failure. Curr Heart Fail Rep. 2014 Jun;11(2):201-11. Doi:10.1007/s11897-014-0190-z. Review. PMID: 24477905. 32. Jumean M, Pham DT, Kapur NK. Percutaneous bi-atrial extracorporeal membrane oxygen for acute circulatory support in advanced heart failure. Catheter Cardiovasc Interv. 2014 Dec 22. Doi:10.1002/ccd.25791. PubMed PMID: 25535957.

147 33. Kalin JA, Madias C, Link MS. Prevention of sudden cardiac death: Commotio cordis. In Emergency Management for Sport and Physical Activity. Edited by Casa and Stearns. Jones and Bartlett. 2014; 53-60. 34. Kapur NK, Paruchuri V. Interventions for failing vessels, valves, and now…ventricles: the parachute device. Catheter Cardiovasc Interv. 2014 Mar 1;83(4):631-2. doi:10.1002/ccd.25398. PubMed PMID: 24532330. 35. Kapur NK, Paruchuri V, Thinh D, Reyelt L, Murphy B, Beale C, Bogins C, Wiener D, Nilson J, Esposito M, Perkins S, Perides G, Karas RH. Hemodynamic Effects of Left Atrial or Left Ventricular Cannulation for Acute Circulatory Support in a Bovine Model of Left Heart Injury. ASAIO J. 2014 Dec 5. PubMed PMID:25485565.

» 36. Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe » PUBLICATIONS IZ, Letarte M, Karas RH. Reducing endoglin activity limits calcineurin and TRPC-6 expression and omproves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014 Jul 11;3(4). pii: e000965. doi: 10.1161/JAHA.114.000965. PubMed PMID: 25015075. 37. Kapur NK, Upshaw J, Kiernan MS, Pham DT. Left ventricular assist device thrombosis presenting as an acute coronary syndrome. J Thorac Cardivasc Surg. 2014 June;147(6):e72-3. doi: 10.1016/j.jtcvs.2014.02.037. PubMed PMID: 24642558. 38. Kiernan MS, French AL, DeNofrio D, Parmar YJ, Pham DT, Kapur NK, Pandian NG, Patel AR. Preoperative Three Dimensional Echocardiography to Assess Risk of Right Ventricular Failure Following Left Ventricular Assist Device Surgery. J Card Fail. 2014 Dec 20. pii. S1071-9164(14)01351-7. doi. 10.1016/j,carfail.2014.12.009. PubMed PMID: 25535957. 39. Kim J, Parikh P, Mahboob M, Arrighi JA, Atalay MK, Rowin EJ, Maron MS. Asymptomatic young man with Danon Disease. Tex Heart Inst J 2014 Jun 14 (3):332-4. 40. Kimmelstiel C, Kapur NK. Low alcohol tolerance – a blessing for septal ablation. Catheter Cardiovasc Interv. 2014 Jul 1;8(1):108-9. doi: 10.1002/ccd.25537. PubMed PMID: 24975263. 41. Klejn S, Pandian NG, Thomas J, Perez de Isla L, Kamp O, Zuber M, Nihoyannopoulos, Forster T, Nesser HJ, Geibel A, Gorrissen W, Zamorano J. Normal reference values of left ventricular strain using three-dimensional speckle tracking echocardiography: results from a multicenter study. Eur Heart J CV Imaging 2014 Oct 26. pii: jeu213. 42. Koenig, Jaffe IZ. Direct Role for Smooth Muscle Cell Mineralocorticoid Receptor in Vascular Remodeling: Novel Mechanisms and Clinical Implications. Invited Review. Curr Hypertens Rep, 2014; 16(5):427. doi:10.1007/s11906- 014-0427-y. PMCID: PMC3951242. 43. Lassnce-Soares RM, Sood S, Chakraborty N, Jhamnani S, Aghili N, Nashin H, Hammamieh R, Jett M, Epstein SE, Burnett MS. Chronic stress impairs collateral blood flow recovery in aged mice. Journal of Cardiovascular Translational Research. 2014 Nov;7(8):749-55. 44. Lawless CE, Asplund C, Asif IM, Courson R, Emery MS, Fuisz A, Kovacs RJ, Lawrence SM, Levine BD, Link MS, Martinez MW, Matherne GP, Olshansky B, Roberts WO, Salberg L, Vetter VL, Vogel RA, Whitehead J. Protecting the Heart of the American Athlete: Proceedings of the American College of Cardiology Sports and Exercise Cardiology Think Tank October 18, 2012, Washington DC. J Am Coll Cardiol. 2014;64:2146-2171. 45. Levine YC, Rosenberg MA, Mittleman M, Samuel M, Methachittiphan N, Link MS, Josephson ME, Buxton AE. B-type natriuretic peptide is a major predictor of ventricular arrhythmias. Heart Rhythm. 2014; 11: 1109-1116. 46. Link MS, Estes NAM 3rd. Sudden Cardiac Deaths in Athletes, Including Commotio Cordis in Zipes D, Clinical Electrophysiology, 2014; 1061-1072. 47. Link MS, Laidlaw D, Polonsky B, Zareba W, McNitt S, Gear K, Marcus F, Estes NAM 3rd. Effectiveness of antitachycardia packing for recurrent ventricular tachycardia… J Am Coll Cardiol. 2014; 64: 2560.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 48. Link MS, Laidlaw D, Polonsky B, Zareba W, McNitt S, Gear K, Marcus F, Estes NA 3rd. Ventricular Arrhythmias in the North Americal Multidisciplinary Study of ARVC: Predictors, Characteristics, and Treatment. J Am Coll Cardiol. 2014 Jul 15;64(2):19-25. 49. Link MS, Luttmann-Gibson H, Schwartz J, et al. Reply: Triggering of cardiac arrhythmias: the proglem of multicollinearity among air pollution and meteorological factors. J Am Coll Cardiol 2014;63(12):1227-8. 50. Love C, Estes NAM 3rd. Following leads to improve patient outcomes: It’s about time Vol. 11, Issue 12, p2163-2164.

51. Majithia A, Estes NAM 3rd, Weinstock J. Advances in sudden death prevention: the emerging role of the fully » » subcutaneous defibrillator. Am J Med. 2014 Mar;127(3):188-94. PUBLICATIONS 52. Malik R, Maron M, Rastegar H, Pandian NG. Hypertrophic cardiomyopathy with right ventricular outflow tract left ventricular intracavitary obstruction. Echocardiography 2014;31:682-685. 53. Malik R, Zilberman M, Tang L, Miller S, Pandian NG. Ectopia cordis with a double outlet right ventricle, large ventricular septal defect, malposed great arteries and left ventricular hypoplasia. Echocardiography 2014. 54. Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak J, Karas RH, Wanke CA. Lipoprotein-associated phospholipase A2 (Lp-PLA2), A novel cardiovascular inflammatory marker, in HIV-infected patients. Clin Infect Dis, 2014; 58:893- 900. PMCID:PMC3935500. 55. Maron BJ, Haas TS, Maron MS, Lesser JR, Browning JA, Chan RH, Olivotto I, Garberich RF, Schwartz RS. Left atrial remodeling in hypertrophic cardiomyopathy and susceptibility markers for atrial fibrillation identified by cardiovascular magnetic resonance. Am J Cardiol 2014:113:1394-400. 56. Maron BJ, Maron MS. The 25-year genetic era in hypertrophic cardiomyopathy: revisited. Circ Cardiovasc Genet 2014;7:401-4. 57. Maron BJ, Ommen SR, Semsarian C, Spirito P, Olivotto I, Maron MS. Hypertrophic cardiomyopathy: present and future, with translation into contemporary cardiovascular medicine. J Am Coll Cardiol 2014;64:83-99. 58. Maron MS. My approach to the clinical management of hypertrophic cardiomyopathy. Trends Cardiovasc Med 2014;24:314-5. 59. Methachittiphan N, Deeprasertkul P, Link MS. Electrocardiographic characteristics of ventricular arrhythmias in inherited channelopathies. In Electrocardiography of Complex Arrhythmias. Cardiac Electrophysiology Clincs. Sep 2014, p 419-432. 60. Meyer TE, Kiernan MS, McManus DD, Shih J. Decision-making under uncertainty in advanced heart failure. Curr Heart Fail Rep. 2014 Jun;11(2):188-96. doi:10.1007/s11897-014-0195-7. Review. PMID: 24691659. 61. Morris AA, Butler J, Konstam MA. Heart Failure with normal ejection fraction, heart failure with preserved ejection fraction, diastolic heart failure, or huff-puff: time for a new taxonomy for hypertensive-metabolic heart failure. J Card Fail. 2014 Oct;20(10):779-81. 62. Pandian NG. 3-Dimensional echocardiography – History and Technical Developments, in book “Three- Dimensional Echocardiography. Ed: Ricardo Ronderos (In Press) 2014. 63. Pandian NG, Ramamurthi A, Applebaum S. Role of echocardiography in arotic stenosis. Prog CV Disease 2014; 57:47-54. 64. Paranandi A, Asztalos BF, Mangili A, Kuvin JT, Gerrior J, Sheehan H, Tang AM, Skinner S, Wanke C. Effects of omega-3 fatty acids on triglycerides and HDL sub-profiles in HIV-infected persons with hypertriglyceridemia. AIDS Res Hum Retroviruses. 2014;30:800-805. 65. Patel AR. “Diastology for the Echo Boards”. In Questions, Tricks, and Tips for the Echocardiography Boards. Eds: Sorrell VS and Jayasuriya S. Wolters Kluwer 2014.

149 66. Peter I, Papandonatos GD, Belalcazar LM, Yang Y, Erar B, Jakicic JM, Unick JL, Balasubramanyam A, Lipkin EW, Delahanty LM, Wagenknecht LE, Wing RR, McCaffery JM, Huggins GS, Look ARG. Genetic modifiers of cardiorespiratory fitness response to lifestyle interventions. Med Sci Sports Exerc 2014;46:302-11. 67. Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA and Jaffe IZ. Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors. Athero Thromb Vasc Biol, 2014;34(2):355-364. PMCID: PMC3951242. 68. Puchner SB, Liu T, Mayrhofer T, Truong QA, Lee H, Fleg JL, Nagurney JT, Udelson JE, Hoffmann U, Ferencik M. High-risk plaque detected on coronary CT angiography predicts acute coronary syndromes independent of » » PUBLICATIONS significant stenosis in acute chest pain: results from the ROMICAT-II trial. J Am Coll Cardiol. 2014;64:684-92. 69. Rock M, Karas AZ, Rodriguez K, Gallo M, Pritchett-Corning K, Karas RH, Aronovitz M, Gaskill B. The time-to- integrate-to-nest as a indicator of wellbeing in laboratory mice. J Am Assoc Lab Anim Sci, 2014; 53:24-28. PMCID: PMC3894644. 70. Rossignol P, Dobre D, Gregory D, Massaro J, Kiernan M, Konstam MA, Zannad F. Incident hyperkalemia may be an independent therapeutic target in low ejection fraction heart failure patients: insight from the HEAL study. Int J Cardiol. 2014 May 15;173(3):380-7. Epub 2014 Feb 28. PMID:24726210. 71. Rowin EJ, Maron BJ, Kiernan MS, Casey SA, Feldman DS, Hryniewicz KM, Chan RH, Harris KM, Udelson JE, DeNofrio D, Roberts WC, Maron MS. Advanced heart failure with preserved systolic function in nonobstructive hypertrophic cardiomyopathy: under-recognized subset of candidates for heart trainsplant. Circ Heart Fail. 2014;7:967-75. PMID:25239116. 72. Ruwald AC, Schuger C, Moss AJ, Kutyifa V, Olshansky B, Greenberg H, Cannom DS, Estes NA, Ruwald MH, Huang DT, Klein H, McNitt S, Beck CA, Goldstein R, Brown MW, Kautzner J, Shoda M, Wilber D, Zareba W, Daubert JP. Mortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillatory Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Circ Arrhythm Electrophysiol. 2014 Oct;7(5):785-92. 73. Saksena S, Marchlinski F, Dimiano R, Estes NAM Interventional Cariac Electrophysiology Cardiotext, Mineapolis, MN, 2014. 74. Sasaki H, Nagayama T, Zhu G, Zhang M, Lee Dong I, Seo K, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Blanton RM, Karas RH, Mendelsohn ME, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014; 124:2464-2471. PMCID: PMC4089449. 75. Selan J, Michaelson M, Fanburg B, Estes NAM. Evaluation and Management of Heart Rhythm, Disturbances Due to Cardiac Sarcoidosis, Circulation Heart and Lunch JACC Cardiovasc Imaging. 2014 Dec;7(12):1249-50. 76. Selker HP, Udelson JE, Massaro JM, Ruthazer R, D’Agostino RB, Griffith JL, Sheehan PR, Desvigne-Nickens P, Rosenberg Y, Tian X, Vickery EM, Atkins JM, Aufderheide TP, Sayah AJ, Pirrallo RG, Levy MK, Richards ME, Braude DA, Doyle DD, Frascone RJ, Kosiak DJ, Leaming JM, Van Gelder CM, Walter GP, Wayne MA, Woolard RH, Beshansky JR. One-Year Outcomes of Out-of-Hospital Administration of Intravenous Glucose, Insulin, and Potassium (GIK) in Patients With Suspected Acute Coronary Syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assesment and Treatment in Emergency Care] Trial). Am J Cardiol. 2014;113:1599-605. 77. Shenoy C, Maron M, Pandian NG. Cardiovascular magnetic resonance imaging for bicuspid aprtic valve syndrome. Editorial commentary. European Heart J, Cardiovascular Imaging 2014;15:612-614. 78. Shenoy C, Pandian NG. Invasive Echocardiography for the Boards, in book chapter in “Tricks, Tips and Questions for the Echocardiography Boards, Ed: Sorrell VL and Jauasuria S. Publisher. Walters Kluwer 2014.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 79. Shenoy C, Salehi HR, Faletra F, Pandian NG. Echocardiography in Ischemic Heart Disease, book chapter, in Textbook of Echocardiography Editor: Navin Nanda. 2014 Publ: Jaypee. 80. Sylvia LM, Ordway L, Pham DT, DeNofrio D, Kiernan M. Bivalrudin for treatment of LVAD thrombosis – a case series. ASAIO J Nov-Dec 60(6):744-7. 2014. PMID:25072553. 81. Thomas SS, Kimmelstiel C. Alcohol Septal Ablation vs Surgical Myectomy for HCM- the Controversy Continues. Catheter Cardiovasc Interv. 2014; 83:278-9. 82. Torromeo C, Evangelista A, Schiatiti M, Puddu P, Pandian NG, Nardinocchi P, Varano V, Gabriele S, Teresi, Piras P.

Torsional correlaties for end systolic volume index in adult healthy subjects. International J Applied Science and » » Technology. 2014: 4:11-21. PUBLICATIONS 83. Urbano-Moral JA, Gangadharamurthy D, Comenzo RL, Pandian NG, Patel AR. Three-dimensional Speckle Tracking Echocardiography in Light Chain Cardiac Amyloidosis: Examination of Left and Right Ventricular Myocardial Mechanics Parameters. Rev Esp Cardiol (In Press) 2014. 84. Urbano-Moral JA, Rowin EJ, Maron MS, Crean A, Pandian NG. Investigation of global and regional myocardial mechanics with 3-dimensional speckle tracking echocardiography and relations to hypertrophy and fibrosis in hypertrophic cardiomyopathy. Circ Cardiovasc Imaging 2014 Jan 7(1):11-9. 85. Vaduganathan M, Dei Cas A, Mentz RJ, Greene SJ, Khan S, Subacius HP, Chioncel O, Maggioni AP, Konstam MA, Senni M, Fonarow GC, Butler J, Gheorghiade M; EVEREST Trial Investigators. Mineralocortidoid receptor antagonist use in hospitalized patients with heart failure, reduced ejection fraction, and diabetes mellitus (from the EVEREST Trial). Am J Cardiol. 2014 Sep 1;114(5):743-50. 86. Vaduganathan M, Green SJ, Ambrosy AP, Mentz RJ, Subacius HP, Chioncel O, Maggiono AP, Swedberg K, Zannad F, Konstam MA, Senni M, Givertz MM, Butler J, Gheorghiade M; EVEREST trial inestigators. Relation of serum uric acid levels and outcomes amoung patient hospitalized for worsening heart failure with reduced ejection fraction (from the efficacy of vasopressin antiagonism in heart failure outcome study with tolvaptan tiral). Am J Cardiol. 2014 Dec 1;114(11):1713-21. 87. Vest AR, Cho LS. Hypertension in pregnancy. Curr Artheroscler Rep. 2014 Mar;16(3):395. 88. Vest AR, Young JB. Should we target obesity in advanced heart failure? Curr Treat Options Cardio Med. 2014 Feb;16(2):284. 89. Volpe G, Wanke G, Imai C, Heffernan K, Kuvin J, Mangili A. High-fat meals do not impair postprandial endothelial function in HIV-infected and uninfected men. AIDS Res Hum Retroviruses. AIDS Res Hum Retroviruses. 2014;30:881-887. 90. Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D. T cells are prevalent in proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One 2014; 9(10):e109416. PMCID:PMC4196850. 91. Weinstock J, Estes NAM. Cardiac Resynchronization Therapy: Extending Current Responses to Phrenic Nerve Stimulation, J Cardiovascular Electrophysiology, 2014, J Cardiovasc Electrophysiol. 2014 May;255):491-3. 92. Wessler BS, Thaler DE, Ruthazer R, et al. Response to letter regarding article, “Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale analysis of putative high-risk features from the risk of paradoxical embolism database”. Circ Cardiovasc Imaging 2014;7(3):573. 93. Wessler BS, Thaler DE, Ruthazer R, et al. Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database. Circ Cardiovasc Imaging 2014;7(1):125-31.

151 94. Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JM, Burke G, Cade B, Chen W, cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, McDonough C, Monda KL, Onland-Moret NC, Nelson CP, O’Connell JR, Ordovas J, Peter I, Peters A, Shaffer J, Shen H, Smith E, Speilotes L, Thomas F, Thorand B, Monique Verschuren WM, Anand SS, Dominiczak A, Davidson KW, Hegele RA, Heid I, Hofker MH, Huggins GS, Illig T, Johnson JA, Kirkland S, Look ARG, Konig W, Langaee TY, McCaffery J, Melander O, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Redline S, Reilly M, Samani NJ, Schork NJ, Van Der Schouw YT, Shimbo D, Shuldiner AR, Tobin MD, Wijmenga C, Yusuf S, Consortium G, Consortium CAI, Hakonarson H, Lange LA, Demerath EW,

» Fox CS, North KE, Reiner AP, Keating B, Taylor KC. Gene-centric meta-analyses for central adiposity traits in up » PUBLICATIONS to 57,412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet 2014;23:2498-510. 95. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, thrombosis, and vascular biology 2014. 96. Zhang Y, Welzig CM, Picard K, Du C, Wang B, Kyriakis J, Aronovitz M, Claycomb W, Blanton R, Park H-J, Galper JB. Glycogen Synthase Kinase-3βInhibition Amerliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice. Diabetes 2014 Jun;63(6):2097-113. PMCID:PMC4030105. Division of Clinical Decision Making 97. Choi H, Hamberger MJ, Munger Clary H, et al. Seizure frequency and patient-centered outcome assessment in epilepsy. Epilepsia 2014;55:1205-12. 98. Concannon TW, Fuster M, Saunders T, et al. A systematic review of stakeholder engagement in comparative effectiveness and patient-centered outcomes research. J Gen Intern Med 2014;29:1692-701. 99. Han PK, Joekes K, Elwyn G, et al. Development and evaluation of a risk communication curriculum for medical students. Patient Educ Couns 2014;94:43-9. 100. Hunink M, Glasziou P, Pliskin J, Weinstein M, Wittenberg E, Drummond M, Wong JB. Decision Making in Health and Medicine, 2nd Ed., Cambridge University Press. 2014. 101. Kassirer JP. Arnold S. Relman, MD, 1923-2014. Am J Kidney Dis 2014;64:A15-6. 102. Kho AN, Hynes DM, Goel S, et al. CAPriCORN: Chicago Area Patient-Centered Outcomes Research Network. J Am Med Inform Assn 2014;21:607-11. Multimodality Writing Group for Stable Ischemic Heart Disease, Wolk MJ, Bailey SR, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Card Fail 2014;20:65-90. 103. Pauker SG. Moments when utilities are functional. Med Decis Making 2014;34:4-7. 104. Pauker SG, Alseiari M. How big is big enough? Thinking about contralateral prophylactic mastectomy. J Natl Cancer I 2014;106. 105. Roman G, Wolk MJ, Bailey SR, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Nucl Cardiol 2014;21:192-220. 106. Rubin CL, Allukian N, Wang X, et al. "We make the path by walking it": building an academic community partnership with Boston Chinatown. Progn Community Health Partnersh 2014;8:353-63. 107. Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 2014;73:492-509. » » 108. Wang C, Iversen MD, McAlindon T, et al. Assessing the comparative effectiveness of Tai Chi versus physical PUBLICATIONS therapy for knee osteoarthritis: design and rationale for a randomized trial. BMC Complem Altern M 2014;14:333. 109. Wedzicha JA, Steinbrook R, Kassirer JP. Should medical journals publish sponsored content? BMJ 2014;348:g352. 110. Wong JB. Evidence-based medicine, pharmacogenetics, and antiplatelet therapy decision making for acute coronary syndrome. Ann Intern Med 2014;160:284-5. 111. Wong JB. Principles of health economics and application to rheumatic disorders. In Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology. 6th Ed., Elsevier, 2014; pp 20-6. Division of Clinical Nutrition 112. Au LE, Harris SS, Dwyer JT, Jacques PF, Sacheck JM. Association of serum 25-hydroxyvitamin D with race/ ethnicity and constitutive skin color in urban schoolchildren. J Pediatr Endocrinol Metab 2014;27:1095-100. 113. Au LE, Harris SS, Jacques PF, Dwyer JT, Sacheck JM. Adherence to a vitamin D supplement intervention in urban schoolchildren. J Acad Nutr Diet 2014;114:86-90. 114. Bailey RL, Saldanha LG, Gahche JJ, Dwyer JT. Estimating caffeine intake from energy drinks and dietary supplements in the United States. Nutr Rev 2014;72 Suppl 1:9-13. 115. Berner LA, Keast DR, Bailey RL, Dwyer JT. Fortified foods are major contributors to nutrient intakes in diets of US children and adolescents. J Acad Nutr Diet 2014;114:1009-22 e8. 116. Byun AJ, Hung KE, Fleet JC, et al. Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Lett 2014;347:191-5. 117. Davidoff F, Rosenberg IH. Association of dietary, circulating, and supplement fatty acids with coronary risk. Ann Intern Med 2014;161:454. 118. Davis CD, Bailey RL, Dwyer JT, Coates PM. John Austin Milner, PhD (1947-2013). J Nutr 2014;144:411-3. 119. Dwyer J. Defining nutritious breakfasts and their benefits. J Acad Nutr Diet 2014;114:S5-7. 120. Dwyer JT, Saldanha LG, Bailen RA, et al. A free new dietary supplement label database for registered dietitian nutritionists. J Acad Nutr Diet 2014;114:1512-7. 121. Dwyer JT, Woteki C, Bailey R, et al. Fortification: new findings and implications. Nutr Rev 2014;72:127-41. 122. Ellwood K, Balentine DA, Dwyer JT, Erdman JW, Jr., Gaine PC, Kwik-Uribe CL. Considerations on an approach for establishing a framework for bioactive food components. Adv Nutr 2014;5:693-701. 123. Feeney MJ, Dwyer J, Hasler-Lewis CM, et al. Mushrooms and Health Summit proceedings. J Nutr 2014;144:1128S-36S.

153 124. Harshman SG, Saltzman E, Booth SL. Vitamin K: dietary intake and requirements in different clinical conditions. Curr Opin Clin Nutr Metab Care 2014;17:531-8. 125. Karl JP, Cheatham RA, Das SK, et al. Effect of glycemic load on eating behavior self-efficacy during weight loss. Appetite 2014;80:204-11. 126. Karl JP, Fu X, Dolnikowski GG, Saltzman E, Booth SL. Quantification of phylloquinone and menaquinones in feces, serum, and food by high-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2014;963:128-33.

» 127. Keusch GT, Denno DM, Black RE, et al. Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical » PUBLICATIONS consequences. Clin Infect Dis 2014;59 Suppl 4:S207-12. 128. Kris-Etherton PM, Akabas SR, Bales CW, et al. The need to advance nutrition education in the training of health care professionals and recommended research to evaluate implementation and effectiveness. Am J Clin Nutr 2014;99:1153S-66S. 129. Kris-Etherton PM, Pratt CA, Saltzman E, Van Horn L. Introduction to nutrition education in training medical and other health care professionals. Am J Clin Nutr 2014;99:1151S-2S. 130. Ma J, Sloan M, Fox CS, et al. Sugar-sweetened beverage consumption is associated with abdominal fat partitioning in healthy adults. J Nutr 2014;144:1283-90. 131. Shaul ME, Hallacoglu B, Sassaroli A, et al. Cerebral blood volume and vasodilation are independently diminished by aging and hypertension: a near infrared spectroscopy study. J Alzheimers Dis 2014;42 Suppl 3:S189-98. 132. Sun L, Dwyer J. Dietetics in China at the crossroads. Asia Pac J Clin Nutr 2014;23:16-26. 133. Urban LE, McCrory MA, Rasmussen H, et al. Independent, additive effects of five dietary variables on ad libitum energy intake in a residential study. Obesity (Silver Spring) 2014;22:2018-25. 134. Wang Y, Gapstur SM, Gaudet MM, Peterson JJ, Dwyer JT, McCullough ML. Evidence for an association of dietary flavonoid intake with breast cancer risk by estrogen receptor status is limited. J Nutr 2014;144:1603-11. 135. Wang Y, Stevens VL, Shah R, et al. Dietary flavonoid and proanthocyanidin intakes and prostate cancer risk in a prospective cohort of US men. Am J Epidemiol 2014;179:974-86. 136. Weaver CM, Dwyer J, Fulgoni VL, 3rd, et al. Processed foods: contributions to nutrition. Am J Clin Nutr 2014;99:1525-42. 137. Zhang FF, Kelly MJ, Saltzman E, Must A, Roberts SB, Parsons SK. Obesity in pediatric ALL survivors: a meta- analysis. Pediatrics 2014;133:e704-15. 138. Zhang FF, Roberts SB, Parsons SK, et al. Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. J Pediatr Hematol Oncol 2014. 139. Zhang FF, Rodday AM, Kelly MJ, et al. Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer 2014;61:1263-9.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Division of Endocrinology 140. Akmal A, Kung J. “Propylthiouracil, and methimazole, and carbimazole-related hepatotoxicity.” Expert Opin Drug Saf. 2014; 13(10):1397-406. 141. Aulet RM, Wein RO, Siegel RD. Surgical management of an atypical presentation of a thyroid storm. Int J Endocrinol Metab. 2014; 1;12(2):e13539. 142. Bassoli E, L. Denti & A. Gatto, G. Spaletta, M. Sofroniou, A. Parrilli, M. Fini, R. Giardino, A. Zamparelli, N. Zini, F. Barbaro, E. Bassi, S. Mosca, D. Dallatana, R. Toni. A planar fractal analysis of the arterial tree of the human »

thyroid gland: implications for additive manufacturing of 3D ramified scaffolds. In: Bartolo PS. et al (Eds). High » PUBLICATIONS Value Manufacturing: Advanced Research in Virtual and Rapid Prototyping, CRC Press, Taylor & Francis group, London, 2014, pp. 423-429. 143. Dawson-Hughes B, Harris SS, Ceglia L, Palmero NJ. Effect of supplemental vitamin D and calcium on serum sclerostin levels. Eur J Endocrinol. 2014; 13;170(4):645-50. 144. Dawson-Hughes B, Harris SS, Lichtenstein AH, Dolnikowski G, Palermo NJ, Rasmussen H. Dietary Fat Increases Vitamin D-3 Absorption. J Acad Nutr Diet. 2014; S2212-2672(14):01468-3. 145. Dawson-Hughes B, Harris SS, Ceglia L, Palermo NJ. Serum sclerostin levels vary with season. J Clin Endocrinol Metab. 2014; 99(1):E149-52 146. Fekete Cs and Lechan RM, Central Regulation of the Hypothalalmic-Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions, Endocrine Rev 2014: 35: 159-194. 147. Harris SS, Dawson-Hughes B. Effects of hydration and calcium supplementation on urine calcium concentration in healthy postmenopausal women. J Am Coll Nutr. 2014. 148. Karl JP, Cheatham RA, Das SK, Hyatt RR, Gilhooly CH, Pittas AG, Lieberman HR, Lerner D, Roberts SB and Saltzman E. Effect of glycemic load on eating behavior self-efficacy during weight loss. Appetite 2104 Sep;80:204-11. 149. Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B and Pittas AG. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. EJCN 2014 Mar;68(3):376-83 150. Mitri J and Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin N Am 2014: Mar;43(1):205-32 151. Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, Mezza T, Vieth R, Colao AA, Pittas A. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol. 2014 Sep;171(3):R101-10. 152. Pittas AG, Dawson-Hughes B, Sheehan, P, Rosen C, Ware JH, Knowler WC, Staten M. Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) Study: A Diabetes Prevention Trial. Diabetes Care. 2014; 37:1-8. 153. Pittas AG. Inhaled Insulin. In: UpToDate, Rose, BD (Ed), UpToDate, Wellesley, MA 2007-2014 154. Pojednic RM, Ceglia L.The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle. Exerc Sport Sci Rev. 2014; 42(2):76-81. 155. Pojednic RM, Ceglia L, Olsson K, Gustafsson T, Lichtenstein AH, Dawson-Hughes B, Fielding RA. Effects of 1,25-Dihydroxyvitamin D3 and Vitamin D 3 on the Expression of the Vitamin D Receptor in Human Skeletal Muscle Cells. Calcif Tissue Int. 2014 Dec 6. [Epub ahead of print]

155 156. Pojednic RM, Ceglia L, Lichtenstein AH, Dawson-Hughes B, Fielding RA. Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle. Endocrine. 2014 Dec 16. [Epub ahead of print] 157. Rizzoli R, Bischoff-Ferrari H, Dawson-Hughes B, Weaver C. Nutrition and Bone Health in Women after the Menopause. Womens Health, 2014; 10(6): 599-608. 158. Rizzoli R, Dawson-Hughes B, Kaufman JM, Fardellone P, Brandi ML, Vellas B, Collette J, Regnister JY, Correction of vitamin D insufficiency with combined strontium renalate and vitamin D3 in osteoporotic patients, Eu J Endocrinol, 2014; 170(3): 441-50.

» 159. Seida JC, Mitri J, Colmers I, Majumdar SR, Davidson MB, Edwards AL, Hanley DA, Pittas AG, Tjosvold L, Johnson » PUBLICATIONS JA. Clinical review: Effect of Vitamin D Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab 2014 Oct;99(10):3551-60. doi: 10.1210/jc.2014-2136. Epub 2014 Jul 25. 160. Siris E S, Adler R, Bilezikian J, Bolonese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Knosla S, Lane NE, Lindsay R, Nana AD, Orwoll ES, Saag K, Silverman S, Watts NB. Clinical diagnosis of osteoporosis: A Consensus Report from the National Bone Health Alliance Working Group. Osteoporosis Int 2014; 25(5): 1439-43. PMID 24577348. 161. Spartano NL, Lamon-Fava S, Matthan NR, Ronxhi J, Greenberg AS, Obin MS, Lichtenstein AH. Regulation of ATP-binding cassette transporters and cholesterol efflux by glucose in primary human monoyctes and bone marrow derived macrophages. Exp Clin Endocrinol Diabetes 2014; 122(8):463-8. 162. Toni R, Taddeo Alderotti e le radici medioevali della terapia steroidea, L’Endocrinologo 2014; 15; 135-138. 163. Toni R, La sindrome di Maestre di San Juan-Kallman- De Morsier, L’Endocrinologo 2014; 15; 82-85. 164. Toni R, I segni di Graefe e Stellwag nell’ipertioidismo, L’Endocrinologo 2014; 15; 186-189. 165. Toni R, La sindrome da inappropriate antidiuresi, L’Endocrinologo 2014; 15; 234-237. 166. Toni R, Cellule da castrazione, castrati e gonadotropinoma, L’Endocrinologo 2014; 15; 36-39. 167. Toni R, Il feocromocitoma e il paraganglioma, ’Endocrinologo 2014; 15: 286-289. 168. Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL6J mice. J. Lipid Res. 2014; 9;55(7): 1448-1464. 169. Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D. γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One. 2014 Oct 14;9(10):e109416. 170. Wittmann G, Singru PS, Nouriel SS, Harney JW, Larsen PR, Lechan RM, Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus and at brain blood vessels: a study in male rats, mice and Syrian hamsters, Endocrinology, 2014; 155: 2009-1019. 171. Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall, S, Dawson-Hughes B. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014; 29(11):2520-6. 172. Zamparelli A, Zini N, Cattin Li, Spaletta G, Dallatana D, Bassi E, Barbaro F, Iafisco M, Mosca S, Parrill Ai, Fin Mi, Giardino R, Sandri M, Sprio S, Tampieri A, Maraldi NM, Toni R. Growth on poly-l-lactic acid porous scaffold preserves CD73 and CD90 immunophenotype markers of rat bone marrow stromal cells. J.Mat. Sci. Mat. Med. 2014; 25: 2421- 2436. 173. Zanetti M, Harris SS, Dawson-Hughes B, Ability of Vitamin D to reduce inflammation in adults without acute illness, Nutr Rev 2014; 72(2): 95-8.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Division of Gastroenterology 174. Bonis PA, The epidemiology and characteristics of eosinophilic esophagitis. Gastroenterol Hepatol (N Y). 2014 Jan;10(1):56-8. PubMed PMID: 24799841; PubMed Central PMCID: PMC4008961. 175. Bonis, PA, Gonzalez A, Sullivan MF, Bonder A, Allison HV, Bonis PA, Guelrud M. Obliteration of symptomatic Schatzki rings with jumbo biopsy forceps (with video). Dis Esophagus. 2014 Sep-Oct;27(7):607-10. doi: 10.1111/ dote.12167. Epub 2014 Feb 19. PubMed PMID: 24552567. 176. Guelrud M, Gonzalez A, Sullivan MF, Bonder A, Allison HV, Bonis PA, Guelrud M. Obliteration of symptomatic »

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157 Division of Geographic Medicine and Infections Diseases 189. Allison GM, Muldoon EG, Kent DM, Paulus JK, Ruthazer R, Ren A, Snydman DR. Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy. Clin Infect Dis. 2014 Mar;58(6):812-9. PubMed PMID: 24357220; PubMed Central PMCID: PMC3935501. 190. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, Puri P, Sterling RK, Luketic V, Stravitz RT, Siddiqui MS, Fuchs M, Thacker LR, Wade JB, Daita K, Sistrun S, White MB, Noble NA, Thorpe C, Kakiyama G, Pandak WM, Sikaroodi M, Gillevet PM. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and

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TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 203. Esposito DH, Stich A, Epelboin L, Malvy D, Han PV, Bottieau E, da Silva A, Zanger P, Slesak G, van Genderen PJ, Rosenthal BM, Cramer JP, Visser LG, Muñoz J, Drew CP, Goldsmith CS, Steiner F, Wagner N, Grobusch MP, Plier DA, Tappe D, Sotir MJ, Brown C, Brunette GW, Fayer R, von Sonnenburg F, Neumayr A, Kozarsky PE; Tioman Island Sarcocystosis Investigation Team. Acute muscular sarcocystosis: an international investigation among ill travelers returning from Tioman Island, Malaysia, 2011-2012. Clin Infect Dis. 2014 Nov 15;59(10):1401-10. PubMed PMID: 25091309. 204. Gelfand JA, Vannier E. Babesia species. In: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th edition. GL Mandell, JE Bennett, R Dolin, eds. Churchill Livingstone. 3165-3172, 2014. » » 205. Griffiths JK, Barza M. Editorial commentary: What happens in hospitals should stay in hospitals. Clin Infect Dis. PUBLICATIONS 2014 Jun;58(12):1666-7. PubMed PMID: 24795327. 206. Hadley S. Resistant gram-positive infections: where have we been, where are we now, and where are we going? Clin Ther. 2014 Oct 1;36(10):1298-302. PubMed PMID: 25287699. 207. Hibberd PL, Kleimola L, Fiorino AM, Botelho C, Haverkamp M, Andreyeva I, Poutsiaka D, Fraser C, Solano- Aguilar G, Snydman DR. No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly-A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses. PLoS One. 2014 Dec 1;9(12):e113456. PubMed PMID: 25438151; PubMed Central PMCID: PMC4249962. 208. Hong SY, Fanelli TJ, Jonas A, Gweshe J, Tjituka F, Sheehan HM, Wanke C, Terrin N, Jordan MR, Tang AM. Household food insecurity associated with antiretroviral therapy adherence among HIV-infected patients in Windhoek, Namibia. J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):e115-22. PubMed PMID: 25356779; PubMed Central PMCID: PMC4215168. 209. Hulgan T, Boger MS, Liao DH, McComsey GA, Wanke CA, Mangili A, Walmsley SL, McCreath H, Milne GL, Sanchez SC, Currier JS, Lake JE. Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. Mediators Inflamm. 2014;2014:803095. PubMed PMID: 24991090; PubMed Central PMCID: PMC4058804. 210. Johnson K, Boucher HW. Editorial commentary: imminent challenges: carbapenem-resistant enterobacteriaceae in transplant recipients and patients with hematologic malignancy. Clin Infect Dis. 2014 May;58(9):1284-6. PubMed PMID: 24463279. 211. Jonas A, Sumbi V, Mwinga S, DeKlerk M, Tjituka F, Penney S, Jordan MR, Desta T, Tang AM, Hong SY. HIV drug resistance early warning indicators in namibia with updated World Health Organization guidance. PLoS One. 2014 Jul 2;9(7):e100539. PubMed PMID: 24988387; PubMed Central PMCID: PMC4079656. 212. Kane AV, DM. Dinh, HD Ward, Childhood Malnutrition and the Intestinal Microbiome Pediatrics Research 2014 Oct 30. doi: 10.1038/pr.2014.179. [Epub ahead of print] 213. Kattula D, Sarkar R, Sivarathinaswamy P, Velusamy, V, Venugopal,S, Naumova, EN, Muliyil,JP, Ward, HD, Kang, G. The first 1000 days of life: Pre- and post-natal risk factors for morbidity and growth in a birth cohort in southern India. BMJ Open 2014;4:e005404 214. Keusch GT, Rosenberg IH, Denno DM, Duggan C, Guerrant RL, Lavery JV, Tarr PI, Ward HD, Black RE, Nataro JP, Ryan ET, Bhutta ZA, Coovadia H, Lima A, Ramakrishna B, Zaidi AK, Burgess DC, Brewer T. Environmental Enteric Dysfunction: Pathogenesis, Diagnosis, and Clinical Consequences. Clin Infect Dis 59 (suppl 4):S207-S212 2014 215. Kogelman L, Barnett ED, Chen LH, Quinn E, Yanni E, Wilson ME, Benoit C, Karchmer AW, Ooi WW, Jentes ES, Hamer DH. Knowledge, attitudes, and practices of US practitioners who provide pre-travel advice. J Travel Med. 2014 Mar-Apr;21(2):104-14. PubMed PMID: 24593023.

159 216. Kuriyan R, Griffiths JK, Finkelstein JL, Thomas T, Raj T, Bosch RJ, Kurpad AV, Duggan C. Innovations in nutrition education and global health: the Bangalore Boston nutrition collaborative. BMC Med Educ. 2014 Jan 8;14:5. PubMed PMID: 24400811; PubMed Central PMCID: PMC3897915. 217. Laws MB, Danielewicz M, Rana A, Kogelman L, Wilson IB. Health Literacy in HIV Treatment: Accurate Understanding of Key Biological Treatment Principles is Not Required for Good ART Adherence. AIDS Behav. 2014 Oct 30. PubMed PMID: 25354736. 218. Lin T, Troy EB, Hu LT, Gao L, Norris SJ. Transposon mutagenesis as an approach to improved understanding of Borrelia pathogenesis and biology. Front Cell Infect Microbiol. 2014 May 20;4:63. PubMed PMID: 24904839; » » PUBLICATIONS PubMed Central PMCID: PMC4033020. 219. Lynch K, Agarwal P, Paranandi A, Hadley S, Vullaganti M. Extensive VZV Encephalomyelitis without Rash in an Elderly Man. Case Rep Neurol Med. 2014;2014:694750. PubMed PMID: 24864218; PubMed Central PMCID: PMC4017713. 220. Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak JF, Karas RH, Wanke CA. Lipoprotein-associated phospholipase A2, a novel cardiovascular inflammatory marker, in HIV-infected patients. Clin Infect Dis. 2014 Mar;58(6):893- 900. PubMed PMID: 24336757; PubMed Central PMCID: PMC3935500. 221. Marques A, Telford SR 3rd, Turk SP, Chung E, Williams C, Dardick K, Krause PJ, Brandeburg C, Crowder CD, Carolan HE, Eshoo MW, Shaw PA, Hu LT. Xenodiagnosis to detect Borrelia burgdorferi infection: a first-in-human study. Clin Infect Dis. 2014 Apr;58(7):937-45. PubMed PMID: 24523212; PubMed Central PMCID: PMC3952603. 222. Masters WA, Webb P, Griffiths JK, Deckelbaum RJ. Agriculture, nutrition, and health in global development: typology and metrics for integrated interventions and research. Ann N Y Acad Sci. 2014 Dec;1331(1):258-69. PubMed PMID: 24571283. 223. McMahon JH, Manoharan A, Wanke C, Mammen S, Jose H, Malini T, Kadavanu T, Jordan MR, Elliott JH, Lewin SR, Mathai D. Targets for intervention to improve virological outcomes for patients receiving free antiretroviral therapy in Tamil Nadu, India. AIDS Care. 2014;26(5):559-66. PubMed PMID: 24125035. 224. Mehrzad R, Barza M. Are physician pagers an outmoded technology? Technol Health Care. 2014 Oct 28. PubMed PMID: 25351275. 225. Muldoon EG, Switkowski K, Tice A, Snydman DR, Allison GM. A national survey of infectious disease practitioners on their use of outpatient parenteral antimicrobial therapy (OPAT). Scand J Infect Dis. 2014 Nov 21:1-7. PubMed PMID: 25415655. 226. Natamba BK, Achan J, Arbach A, Oyok TO, Ghosh S, Mehta S, Stoltzfus RJ, Griffiths JK, Young SL. Reliability and validity of the center for epidemiologic studies-depression scale in screening for depression among HIV-infected and -uninfected pregnant women attending antenatal services in northern Uganda: a cross-sectional study. BMC Psychiatry. 2014 Nov 22;14(1):303. PubMed PMID: 25416286; PubMed Central PMCID: PMC4260190. 227. Natamba BK, Kilama H, Arbach A, Achan J, Griffiths JK, Young SL. Reliability and validity of an individually focused food insecurity access scale for assessing inadequate access to food among pregnant Ugandan women of mixed HIV status. Public Health Nutr. 2014 Aug 29:1-11. PubMed PMID: 25171462. 228. Nichols BE, Sigaloff KC, Kityo C, Hamers RL, Baltussen R, Bertagnolio S, Jordan MR, Hallett TB, Boucher CA, de Wit TF, van de Vijver DA. Increasing the use of second-line therapy is a cost-effective approach to prevent the spread of drug-resistant HIV: a mathematical modelling study. J Int AIDS Soc. 2014 Dec 5;17:19164. PubMed PMID: 25491351; PubMed Central PMCID: PMC4260459.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 229. Nierenberg NE, Poutsiaka DD, Chow JK, Cooper J, Price LL, Freeman RB, Rohrer R, Snydman DR. Pretransplant lymphopenia is a novel prognostic factor in cytomegalovirus and noncytomegalovirus invasive infections after liver transplantation. Liver Transpl. 2014 Dec;20(12):1497-507. PubMed PMID: 25205044. 230. O'Connor RM, Fung JM, Sharp KH, Benner JS, McClung C, Cushing S, Lamkin ER, Fomenkov AI, Henrissat B, Londer YY, Scholz MB, Posfai J, Malfatti S, Tringe SG, Woyke T, Malmstrom RR, Coleman-Derr D, Altamia MA, Dedrick S, Kaluziak ST, Haygood MG, Distel DL. Gill bacteria enable a novel digestive strategy in a wood-feeding mollusk. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5096-104. PubMed PMID: 25385629; PubMed Central PMCID: PMC4250168. » » 231. Paluszynski J, Monahan Z, Williams M, Lai O, Morris C, Burns P, O'Connor R. Biochemical and functional PUBLICATIONS characterization of CpMuc4, a Cryptosporidium surface antigen that binds to host epithelial cells. Mol Biochem Parasitol. 2014 Feb;193(2):114-21. PubMed PMID: 24690740; PubMed Central PMCID: PMC4073680. 232. Paranandi A, Asztalos BF, Mangili A, Kuvin J, Gerrior J, Sheehan H, Skinner SC, Tang AM, Wanke CA. Short communication: effects of omega-3 fatty acids on triglycerides and high-density lipoprotein subprofiles in HIV- infected persons with hypertriglyceridemia. AIDS Res Hum Retroviruses. 2014 Aug;30(8):800-5. PubMed PMID: 24988179; PubMed Central PMCID: PMC4118719. 233. Phillips AN, Cambiano V, Miners A, Revill P, Pillay D, Lundgren JD, Bennett D, Raizes E, Nakagawa F, DeLuca A, Vitoria M, Barcarolo J, Perriens J, Jordan MR, Bertagnolio S. 234. Effectiveness and cost-effectiveness of potential responses to future high levels of transmitted HIV drug resistance in antiretroviral drug-naïve populations beginning treatment: modeling study and economic analysis. The Lancet HIV 2014;1(2):e85-e93. 235. Safren SA, Biello KB, Smeaton L, Mimiaga MJ, Walawander A, Lama JR, Rana A, Nyirenda M, Kayoyo VM, Samaneka W, Joglekar A, Celentano D, Martinez A, Remmert JE, Nair A, Lalloo UG, Kumarasamy N, Hakim J, Campbell TB; PEARLS (ACTG A5175) Study Team. Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial. PLoS One. 2014 Aug 25;9(8):e104178. PubMed PMID: 25153084; PubMed Central PMCID: PMC4143224. 236. Sarkar R, Kattula D, Francis MR, Ajjampur SS, Prabakaran AD, Jayavelu N, Muliyil J, Balraj V, Naumova EN, Ward HD, Kang G. Risk factors for cryptosporidiosis among children in a semi urban slum in southern India: a nested case-control study. Am J Trop Med Hyg. 2014 Dec 3;91(6):1128-37. PubMed PMID: 25331810; PubMed Central PMCID: PMC4257634. 237. Sarkar R, Tate JE, Ajjampur SS, Kattula D, John J, Ward HD, Kang G. Burden of diarrhea, hospitalization and mortality due to cryptosporidial infections in Indian children. PLoS Negl Trop Dis. 2014 Jul 24;8(7):e3042. PubMed PMID: 25058664; PubMed Central PMCID: PMC4109911. 238. Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA. The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol. 2014 Mar 1;192(5):2291-304. PubMed PMID: 24477914; PubMed Central PMCID: PMC3943885. 239. Shi Y, Dadhwal P, Li X, Liang FT. BosR functions as a repressor of the ospAB operon in Borrelia burgdorferi. PLoS One. 2014 Oct 1;9(10):e109307. doi: 10.1371/journal.pone.0109307. eCollection 2014. PubMed PMID: 25271631; PubMed Central PMCID: PMC4182837. 240. Sindhu KN, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SS, Priyadarshini S, Sarkar R, Balasubramanian KA, Wanke CA, Ward HD, Kang G. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2014 Apr;58(8):1107-15. PubMed PMID: 24501384; PubMed Central PMCID: PMC3967829.

161 241. Sluis-Cremer N, Jordan MR, Huber K, Wallis CL, Bertagnolio S, Mellors JW, Parkin NT, Harrigan PR. E138A in HIV-1 reverse transcriptase is more common in subtype C than B: implications for rilpivirine use in resource- limited settings. Antiviral Res. 2014 Jul;107:31-4. PubMed PMID: 24746459; PubMed Central PMCID: PMC4089891. 242. Snydman DR, McDermott LA, Jacobus NV. Activity of ceftolozane-tazobactam against a broad spectrum of recent clinical anaerobic isolates. Antimicrob Agents Chemother. 2014;58(2):1218-23. PubMed PMID: 24277025; PubMed Central PMCID: PMC3910869. 243. Snydman DR. Editorial commentary: the complexity of latent cytomegalovirus infection in stem cell donors. Clin » » PUBLICATIONS Infect Dis. 2014 Aug 15;59(4):482-3. PubMed PMID: 24850803. 244. Sponseller JK, Griffiths JK, Tzipori S. The evolution of respiratory Cryptosporidiosis: evidence for transmission by inhalation. Clin Microbiol Rev. 2014 Jul;27(3):575-86. PubMed PMID: 24982322; PubMed Central PMCID: PMC4135895. 245. Taylor LE, Foont JA, DeLong AK, Wurcel A, Linas BP, Chapman S, Maynard MA, Cu-Uvin S, Mayer KH. The spectrum of undiagnosed hepatitis C virus infection in a US HIV clinic. AIDS Patient Care STDS. 2014 Jan;28(1):4- 9. PubMed PMID: 24428794; PubMed Central PMCID: PMC3894677. 246. Telford SR 3rd, Hu LT, Marques A. Is there a place for xenodiagnosis in the clinic? Expert Rev Anti Infect Ther. 2014 Nov;12(11):1307-10. PubMed PMID: 25301228. 247. Thibodeau E, Doron S, Iacoviello V, Schimmel J, Snydman DR. Carbapenem-resistant enterobacteriaceae: analyzing knowledge and practice in healthcare providers. Peer J. 2014 May 22;2:e405. PubMed PMID: 24883259; PubMed Central PMCID: PMC4034608. 248. Traa MX, Barboza L, Doron S, Snydman DR, Noubary F, Nasraway SA Jr. Horizontal infection control strategy decreases methicillin-resistant Staphylococcus aureus infection and eliminates bacteremia in a surgical ICU without active surveillance. Crit Care Med. 2014 Oct;42(10):2151-7. PubMed PMID: 24979485. 249. Vannier E, Krause PJ. Babesiosis in China, an emerging threat. Lancet Infect Dis. 2014 Dec 19. pii: S1473- 3099(14)71062-X. PubMed PMID: 25539585. 250. Volpe GE, Wanke CA, Imai CM, Heffernan KS, Kuvin JT, Mangili A. High-fat meals do not impair postprandial endothelial function in HIV-infected and uninfected men. AIDS Res Hum Retroviruses. 2014 Sep;30(9):881-7. doi: 10.1089/AID.2013.0272. Epub 2014 Jun 26. PubMed PMID: 24892462; PubMed Central PMCID: PMC4151053. 251. Volpe GE, Ward H, Mwamburi M, Dinh D, Bhalchandra S, Wanke C, Kane AV. Associations of cocaine use and HIV infection with the intestinal microbiota, microbial translocation, and inflammation. J Stud Alcohol Drugs. 2014 Mar;75(2):347-57. PubMed PMID: 24650829; PubMed Central PMCID: PMC3965688. 252. Wang P, Glowacki MN, Hoet AE, Needham GR, Smith KA, Gary RE, Li X. Emergence of Ixodes scapularis and Borrelia burgdorferi, the Lyme disease vector and agent, in Ohio. Frontiers in Cellular and Infection Microbiology 2014 Jun 4;4:70. doi: 10.3389/fcimb.2014.00070. eCollection 2014. PubMed PMID: 24926441; PubMed Central PMCID: PMC4044495 253. Wanyiri JW, Kanyi H, Maina S, Wang DE, Steen A, Ngugi P, Kamau T, Waithera T, O'Connor R, Gachuhi K, Wamae CN, Mwamburi M, Ward HD. Cryptosporidiosis in HIV/AIDS patients in Kenya: clinical features, epidemiology, molecular characterization and antibody responses. Am J Trop Med Hyg. 2014 Aug;91(2):319-28. PubMed Central PMCID: PMC4125256. 254. Weston A, Golan Y, Holcroft C, Snydman DR. The efficacy of daptomycin versus vancomycin for methicillin- resistant Staphylococcus aureus bloodstream infection in patients with impaired renal function. Clin Infect Dis. 2014 Jun;58(11):1533-9. PubMed PMID: 24642554; PubMed Central PMCID: PMC4017894.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Division of Hematology/Oncology 255. Abramson JS, Feldman T, Kroll-Desrosiers AR, et al. Evens, AM Peripheral T-cell lymphomas in a large US multicenter cohort: prognostication in the modern era including impact of frontline therapy. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2014;25:2211-7. 256. Agarwal A, Saif MW KRAS in pancreatic cancer. JOP. 2014 Jul 28;15(4):303-5. doi: 10.6092/1590-8577/2660. PMID: 25076326 [PubMed - in process] Free Article 257. Agarwal A, Daly KP, Butler-Bowen H, Saif MW. Safety and efficacy of radiofrequency ablation with aflibercept »

and FOLFIRI in a patient with metastatic colorectal cancer. Anticancer Res. 2014 Nov;34(11):6775-8. PMID: » PUBLICATIONS 25368290 [PubMed - indexed for MEDLINE] 258. Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, and Kuperwasser C. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast Cancer Research 2014;16:453 259. Ballen KK, Joffe S, Brazauskas R, Wang Z, Alijurf MD, Akpek G, Dandoy C, Frangoul HA, Freytes CO, Khera N, Lazarus HM, LeMaistre CF, Mehta P, Parsons SK, Szwajcer D, Ustun C, Wood WA, Majahil NS. Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison among Alternative Graft Sources. Biol Blood Marrow Transplant 2014 Jul 23; 20 (11): 1819-1827. doi: 10.1016/j.bbmt.2014.07.021. [Epub ahead of print]. PMID: 25064747 260. Bhalla A, Saif MW. PARP-inhibitors in BRCA-associated pancreatic cancer. JOP. 2014 Jul 28;15(4):340-3. doi: 10.6092/1590-8577/2690. PMID: 25076338 [PubMed - in process] Free Article 261. Boxerman JL, Ellingson BM, Jeyapalan S, Elinzano H, Harris RJ, Rogg JM, Pope WB, Safran H. Longitudinal DSC- MRI for Distinguishing Tumor Recurrence From Pseudoprogression in Patients With a High-grade Glioma. Am J Clin Oncol. 2014 Nov 26. [Epub ahead of print] PMID: 25436828 262. Burney S, Khawaja KI, Saif MW, Masud F. Chemotherapy and metformin in pancreatic adenocarcinoma and neuroendocrine tumors. JOP. 2014 Jul 28;15(4):313-6. doi: 10.6092/1590-8577/2677. PMID: 25076330 [PubMed - in process] Free Article 263. Burney S, Irfan K, Saif MW, Masud F. Diabetes and pancreatic cancer. JOP. 2014 Jul 28;15(4):319-21. doi: 10.6092/1590-8577/2680. PMID: 25076332 [PubMed - in process] Free Article 264. Caprario, LC Strauss, GM, The benefit of chemotherapy in elderly patients with small cell lung cancer, Expert Review of Anticancer Therapy, 2014. 265. Casavant D, McManus M, Parsons S, Zurakowski D, Graham R. Trial of telemedicine for patients on home ventilator support: Feasibility, confidence in clinical management and use in medical decision-making. J Telemed Telecare 2014 October 14. DOI: 10.1177/ 1357633X14555620. 266. Cerulli RS, Dashnamoorthy R, Evens AM. The Bruton’s Tyrosine Kinase Inhibitor CC-292 in Diffuse Large B-Cell Lymphoma (DLBCL), T-Cell Lymphoma (TCL), and Hodgkin Lymphoma (HL): Induction of Cell Death and Examination of Rational Novel/Novel Therapeutic Combinations. Blood (ASH): 2014; 124 (21): 1772. 267. Chandhok NS, Saif MW. Updates on the use of neoadjuvant therapy in borderline resectable pancreatic cancer. JOP. 2014 Mar 10;15(2):91-4. doi: 10.6092/1590-8577/2303. PMID: 24618425 [PubMed - indexed for MEDLINE] Free Article 268. Chaulagain C, Pilichowska M, Brinckerhoff M, Tabba M, and Erban J. Secondary Pulmonary Alveolar Proteinosis in Hematologic Malignancies. Hematology and Stem Cell Therapy 2014. Hematol Oncol Stem Cell Ther. 2014: 7(4):127-35

163 269. Chen J, Elfiky A, Han M, Chen C, Saif MW. The role of Src in colon cancer and its therapeutic implications. Clin Colorectal Cancer. 2014 Mar;13(1):5-13. doi: 10.1016/j.clcc.2013.10.003. Epub 2013 Nov 13. Review. PMID: 24361441 [PubMed - indexed for MEDLINE] 270. Christopoulos A, Saif MW, Sarris EG, Syrigos KN. Epidemiology of active tuberculosis in lung cancer patients: a systematic review. Clin Respir J. 2014 Oct;8(4):375-81. doi: 10.1111/crj.12094. Epub 2014 Mar 5. PMID: 24345074 [PubMed - in process] 271. Choi M, Saif MW, Kim R. Is there a role for second line therapy in advanced pancreatic cancer? JOP. 2014 Mar 10;15(2):106-9. doi: 10.6092/1590-8577/2325. PMID: 24618429 [PubMed - indexed for MEDLINE] Free Article » » PUBLICATIONS 272. Chu E, Haller D, Cartwright T, Twelves C, Cassidy J, Sun W, Saif MW, McKenna E, Lee S, Schmoll HJ. Epidemiology and natural history of central venous access device use and infusion pump function in the NO16966 trial. Br J Cancer. 2014 Mar 18;110(6):1438-45. doi: 10.1038/bjc.2014.74. Epub 2014 Feb 18. PMID: 24548866 [PubMed - indexed for MEDLINE] 273. Cohen JT, Lin P and Parsons SK: Economic issues in pediatric cancer. In: Pizzo PA and Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams and Wilkins, 2014; Seventh edition; in press. 274. Comenzo RL. LECT2 makes the amyloid list. Blood 2014;123:1436. 275. Comenzo RL. Plasma Cell Neoplasms, Their Precursor States and Their Prediction of Organ Damage. J Clin Oncol 2014;32:2679-82. 276. Cunningham J, Kantekure K, Saif MW. Medullary carcinoma of the colon: a case series and review of the literature. In Vivo. 2014 May-Jun;28(3):311-4. Review. PMID: 24815832 [PubMed - indexed for MEDLINE] 277. Daoud V, Saif MW, Goodman M. Adjuvant treatment for pancreatic cancer. JOP. 2014 Jul 28;15(4):348-50. doi: 10.6092/1590-8577/2692. PMID: 25076340 [PubMed - in process] Free Article 278. Dashnamoorthy R, Abermil N, Behesti A, Kozlowski P, Lansigan F, Kinlaw W, Gartenhaus R, Jones G, Hlatky L, Evens AM. The Lipid Addiction of Diffuse Large B-Cell Lymphoma (DLBCL) and Potential Treatment Strategies with Novel Fatty Acid Synthase (FASN) Small Molecule Inhibitors. Blood (ASH): 2014; 124 (21): 4490. 279. Dashnamoorthy R, Behesti A, Abermil N, Sharma J, Coyle M, Kandela I, Mazar A, Hlatky L, Evens AM. Genome- Wide Analysis Reveals MYC-Dependent Cell Death and Identifies Predictive Biomarkers of Ixazomib Sensitivity in Preclinical Models of T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL). Blood (ASH): 2014; 124 (21): 3120. 280. Dashnamoorthy, R, Bhalla S, Gartenhaus RB, Evens AM. Et al. The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models Clinical cancer research: an official journal of the American Association for Cancer Research 2014;20:6023-33. 281. De Souza AL, Saif MW. Platinum-based therapy in adenosquamous pancreatic cancer: experience at two institutions. JOP. 2014 Mar 10;15(2):144-6. doi: 10.6092/1590-8577/2358. PMID: 24618440 [PubMed - indexed for MEDLINE] Free Article 282. De Souza AL, Saif MW. Diabetes and pancreatic cancer. JOP. 2014 Mar 10;15(2):118-20. doi: 10.6092/1590- 8577/2286. PMID: 24618432 [PubMed - indexed for MEDLINE] Free Article 283. De Souza AL, Saif MW. Thromboembolism and pancreatic cancer. JOP. 2014 Jul 28;15(4):292-4. doi: 10.6092/1590-8577/2574. PMID: 25076323 [PubMed - in process] Free Article 284. De Souza AL, Saif MW. Squamous cell carcinoma of the pancreas. JOP. 2014 Nov 28;15(6):630-1. doi: 10.6092/1590-8577/2718. No abstract available. PMID: 25435587 [PubMed - in process] Free Article

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 285. DeVita MD, Evens AM, Rosen ST, Greenberger PA, Petrich AM. Multiple successful desensitizations to brentuximab vedotin: a case report and literature review. Journal of the National Comprehensive Cancer Network : JNCCN 2014;12:465-71. 286. El-Jurdi NH, Saif MW. Should ageism be a stratification factor in patients with pancreatic cancer? JOP. 2014 Mar 10;15(2):147-50. doi: 10.6092/1590-8577/2281. PMID: 24618441 [PubMed - indexed for MEDLINE] Free Article 287. El-Jurdi NH, Saif MW. Pancreatic cancer: new hopes for early detection and a future screening tool? JOP. 2014 Jul 28;15(4):358-9. doi: 10.6092/1590-8577/2696. PMID: 25076343 [PubMed - in process] Free Article

288. Evens AM, Smith MR, Lossos IS, Helenowski I, Millenson M, Winter JN, Rosen ST, Gordon LI. Frontline » » bortezomib and rituximab for the treatment of newly diagnosed high tumor burden (HTB) indolent non- PUBLICATIONS Hodgkin lymphoma (iNHL): A multicenter phase II study. J Clin Oncol (ASCO) 32:5s, 2014 (suppl; abstr 8545). 289. Evens AM, Kostakoglu L The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. Blood 2014;124:3356-64. 290. Evens AM. Non Hodgkin’s Lymphoma. Section 13, Hematology. In: Bope & Kellerman, eds. Conn's Current Therapy, 66th edition, 2014. 291. Evens AM, Winter JN, Gordon LI, Chiu Brian C.-H.,Tsang R, Rosen ST. Non-Hodgkin lymphoma. In: Haller D, Wagman LD, Camphausen KA, Hoskins WJ, eds. A Multidisciplinary Approach, 17th edition, 2014. 292. Evens AM, Smith MR, Lossos IS, et al. Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma: a multicentre phase II study. British journal of haematology 2014;166:514-20. 293. Foley, C.J., Fanjul-Fernandez, M., Bohm, A., Agarwal, A., Koukos, G., Covic, L., Lopez-Otin, C. & Kuliopulos, A. Matrix Metalloprotease-1a Deficiency Suppresses Tumor Growth and Angiogenesis. (2014) Oncogene 33:2264-72. 294. Foley, C.J. & Kuliopulos, A. Mouse Matrix Metalloprotease-1a (Mmp1a) Gives New Insight into MMP1 Function. (2014) J. Cellular Physiol. 229:1875-80 295. Flores JP, Saif MW. Chapter –Pancreatic Cancer. Prof. S, Eds. In: Clinical Oncology for Tablets 2014 296. Gandhi M, Ma S, Smith SM, Nabhan C, Evens AM, JN Winter, Gordon LI, Petrich AM. Brentuximab Vedotin (BV) Plus Rituximab (R) As Frontline Therapy for Patients (Pts) with Epstein Barr Virus (EBV)+ and/or CD30+ Lymphoma: Phase I Results of an Ongoing Phase I-II Study. Blood (ASH): 2014; 124 (21): 3096. 297. Gandhi MD, Evens AM, Fenske TS, et al. Pancreatitis in patients treated with brentuximab vedotin: a previously unrecognized serious adverse event. Blood 2014;123:2895-7. 298. Gentzler RD, Evens AM, Rademaker AW, et al. F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma. British journal of haematology 2014;165:793-800. 299. Goodman MD, Saif MW. Adjuvant therapy for pancreatic cancer. JOP. 2014 Mar 10;15(2):87-90. doi: 10.6092/1590-8577/2324. PMID: 24618424 [PubMed - indexed for MEDLINE] Free Article 300. Gorovets D, Saif MW, Huber K. Novel treatment approaches for locally advanced pancreatic cancer. JOP. 2014 Mar 10;15(2):95-8. doi: 10.6092/1590-8577/2284. PMID: 24618426 [PubMed - indexed for MEDLINE] Free Article 301. Graham RJ, Rodday AM, Parsons SK. Family-Centered Assessment and Function for Children with Chronic Mechanical Respiratory Support. J Pediatr Health Care 2014, Jul-Aug; 28(4):295-304. doi: 10.1016/j. pedhc.2013.06.006. 2013 Aug 12.[Epub ahead of print]. PMID: 23942254

165 302. Grapsa D, Dokou A, Tsokanou-Kouli V, Kaltsas S, Dalakou E, Trigidou R, Saif MW, Politi E. Immunohistochemical expression of p53, p63, c-myc, p21(WAF1/cip1) and p27(kip1) proteins in urothelial bladder carcinoma: correlation with clinicopathological parameters. J BUON. 2014 Oct-Dec;19(4):1121-4.PMID: 25536625 [PubMed - in process] 303. Graziani C, Hegde S, Saif MW. Radiation recall gastritis secondary to erlotinib in a patient with pancreatic cancer. Anticancer Res. 2014 Dec;34(12):7339-43. PMID: 25503169 [PubMed - in process] 304. Greenough A, Moffitt A, Healy J, Patel A, Richards KL, Fedoriw YD, Dunphy C, Choi WWL, Srivastava G Czader M, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh K, Chadburn A, Gordon LI, Evens AM, Gill J, Collie AMB, » » PUBLICATIONS Hsi ED, Love CL, Dave SS. Strand-Specific Total RNA Sequencing Establishes the Complete Transcriptome and Alternative Splicing Repertoire in Diffuse Large B Cell Lymphoma. Blood (ASH): 2014; 124 (21): 864. 305. H Toki MI, Saif MW, Syrigos KN ypersensitivity reactions associated with oxaliplatin and their clinical management. Expert Opin Drug Saf. 2014 Nov;13(11):1545-54. doi: 10.1517/14740338.2014.963551. Epub 2014 Oct 11. PMID: 25307143 [PubMed - in process] 306. Ho VT, Kim HT, Kao G, Cutler C, Levine J, Rosenblatt J, Joyce R, Antin JH, Soiffer RJ, Ritz J, Avigan D, Alyea EP . Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2014 Dec;89(12):1092-6. 307. Hosein PJ, Maragulia JC, Salzberg MP, et al. A multicentre study of primary breast diffuse large B-cell lymphoma in the rituximab era. British journal of haematology 2014;165:358-63. 308. Jaccard A, Comenzo RL, Hari P, et al. Efficacy of bortezomib, cyclophosphamide and dexamethasone in treatment-naïve patients with high-risk cardiac AL amyloidosis (Mayo Clinic stage III). Haematologica. 2014;99:1479-85. 309. Jeyapalan S, Boxerman J, Donahue J, Goldman M, Kinsella T, Dipetrillo T, Evans D, Elinzano H, Constantinou M, Stopa E, Puthawala Y, Cielo D, Santaniello A, Oyelese A, Mantripragada K, Rosati K, Isdale D, Safran H; Brown University Oncology Group Study. Paclitaxel poliglumex, temozolomide, and radiation for newly diagnosed high-grade glioma: a Brown University Oncology Group Study. Am J Clin Oncol. 2014 Oct;37(5):444-9. doi: 10.1097/COC.0b013e31827de92b. PMID: 23388562 310. John PK, Kougioumtzopoulou AS, Syrigos KN, Saif MW. Updates in management of ampullary carcinomas. JOP. 2014 Mar 10;15(2):140-3. doi: 10.6092/1590-8577/2283. 311. PMID: 24618439 [PubMed - indexed for MEDLINE] Free Article John PK, Saif MW. Radioembolization in the treatment of neuroendocrine tumors of the pancreas. JOP. 2014 Jul 28;15(4):332-4. doi: 10.6092/1590-8577/2688. PMID: 25076336 [PubMed - in process] Free Article 312. John P, Butler H, Saif MW. Congestive heart failure secondary to gemcitabine nab-paclitaxel in patients with pancreatic cancer. Anticancer Res. 2014 Dec;34(12):7267-70. PMID: 25503159 [PubMed - in process] 313. Johung KL, Saif MW, Chang BW. Locally advanced unresectable pancreatic cancer. JOP. 2014 Jul 28;15(4):329-31. doi: 10.6092/1590-8577/2684. PMID: 25076335 [PubMed - in process] Free Article 314. Joza N, Saif MW. Biomarkers in pancreatic adenocarcinoma. JOP. 2014 Jul 28;15(4):308-9. doi: 10.6092/1590- 8577/2675. PMID: 25076328 [PubMed - in process] Free Article 315. Kaddis N, Saif MW. Second-line treatment for pancreatic cancer. JOP. 2014 Jul 28;15(4):344-7. doi: 10.6092/1590- 8577/2691. PMID: 25076339 [PubMed - in process] Free Article 316. Kaltsas S, Syrigos KN, Saif MW. Pancreatic cancer in 2014. JOP. 2014 Mar 10;15(2):84-6. doi: 10.6092/1590- 8577/2403. No abstract available. PMID: 24618423 [PubMed - indexed for MEDLINE] Free Article 317. Karampelas IN, Syrigos KN, Saif MW. Targeted agents in treatment of neuroendocrine tumors of pancreas. JOP. 2014 Jul 28;15(4):351-3. doi: 10.6092/1590-8577/2694. PMID: 25076341 [PubMed - in process] Free Article

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 318. Kaul E, Shah G, Chaulagain C, Comenzo RL. Plerixafor and G-CSF for Autologous Stem Cell Mobilization in AL Amyloidosis. Bone Marrow Transplant 2014;49:1233. 319. Kelly MJ, Horan JT, Alonzo TA, Eapen M, Gerbing RB, He W, Lange BJ, Parsons SK, Woods WG. Comparable survival for pediatric acute myeloid leukemia with poor-risk cytogenetics following chemotherapy, matched related donor, or unrelated donor transplantation. Pediatr Blood Cancer 2014 , 61 (2): 269-75. 2013 Aug 19 [Epub ahead of print]. doi: 10.1002/pbc.24739. PMID: 23955900, PMCID: PMC3919967 320. Khagi S, Saif MW. Gastroenteropancreatic neuroendocrine tumors: hormonal treatment updates. JOP. 2014 Mar 10;15(2):135-7. doi: 10.6092/1590-8577/2287. PMID: 24618437 [PubMed - indexed for MEDLINE] Free Article » » 321. Khagi S, Saif MW. The management of gastroenteropancreatic neuroendocrine tumors with somatostatin PUBLICATIONS analogues. JOP. 2014 Jul 28;15(4):295-8. doi: 10.6092/1590-8577/2619. PMID: 25076324 [PubMed - in process] Free Article 322. Khouri J, Saif MW. Intraductal papillary mucinous neoplasms of the pancreas (IPMNs): new insights on clinical outcomes and malignant progression. JOP. 2014 Jul 28;15(4):310-2. doi: 10.6092/1590-8577/2676. PMID: 25076329 [PubMed - in process] Free Article 323. Kiagia M, Syrigos KN, Saif MW. Quality of life in patients with pancreatic cancer. JOP. 2014 Jul 28;15(4):317-8. doi: 10.6092/1590-8577/2679. PMID: 25076331 [PubMed - in process] Free Article 324. Kim HT1, Frederick D, Armand P, Andler E, Kao G, Cutler C, Koreth J, Alyea EP 3rd, Antin JH, Soiffer RJ, Ritz J, Ho VT. White blood cell recovery after allogeneic hematopoietic cell transplantation predicts clinical outcome. Am J Hematol. 2014 Jun;89(6):591-7. 325. Knopf K, Duh MS, Lafeuille MH, et al. Meta-Analysis Of The Efficacy And Safety Of Bortezomib Retreatment In Patients With Multiple Myeloma. Clinical Lymphoma, Myeloma & Leukemia 2014;14:380-8. 326. Kougioumtzopoulou AS, Syrigos KN, Saif MW. Elderly patients with pancreatic cancer. JOP. 2014 Jul 28;15(4):322- 5. doi: 10.6092/1590-8577/2682. PMID: 25076333 [PubMed - in process] Free Article 327. Kostakoglu L, Evens, AM. FDG-PET imaging for Hodgkin lymphoma: current use and future applications. Clinical advances in hematology & oncology : H&O 2014;12:20-35. 328. Krishnamoorthy SK, Jambawaliker S, Saif MW. Positron emission tomography imaging of pancreatic cancer. JOP. 2014 Mar 10;15(2):124-7. doi: 10.6092/1590-8577/2326. PMID: 24618434 [PubMed - indexed for MEDLINE] Free Article 329. Krishnamoorthy SK, Saif MW. PET scanning: worth the cost in cancer? Not for all cancers--it's not reliable enough yet. Oncology (Williston Park). 2014 May;28(5):391-2. No abstract available. PMID: 25004652 [PubMed - indexed for MEDLINE] Free Article 330. Kritharis A, Kanakry JA, Sehn LH, Feldman T, Kroll A, Gascoyne RD, Petrich AM, Abramson JS, Hernandez- Ilizaliturri F, Al-Mansour Z, Adeimy C, Hemminger J, Bartlett NL, Mato AR, Caimi P, Advani R, Klein AK, Lossos IS, Press OW, Smith SM, Fabregas JC, Nabhan C, Fenske TS, Friedberg JW, Vose JM, Blum KA, Evens AM. Gray Zone Lymphoma (GZL) with Features Intermediate Between Classical Hodgkin Lymphoma (cHL) and Diffuse Large B-Cell Lymphoma (DLBCL): Analysis of Tumor Immunophenotype (IP) and Critical Examination of Therapy with Associated Impact on Outcome. Blood (ASH): 2014; 124 (21): 1703. 331. Kritharis A, Fowler T, Dashnamoorthy R, Burgess KE, Beheshti A Abermil N, Roy A, Hlatky L, Pilichowska M, McNiel E, Evens AM. A Comparative Oncology Study of Canine and Human Genomics and Proteomics in Peripheral T-Cell Lymphoma (PTCL): Examination of Shared Oncogenic Signaling for Biomarker and Therapeutic Target Discovery. Blood (ASH): 2014; 124 (21): 3019.

167 332. Li J, Saif MW. Role of neoadjuvant therapy in management of pancreatic cancer. JOP. 2014 Jul 28;15(4):354-7. doi: 10.6092/1590-8577/2695. PMID: 25076342 [PubMed - in process] Free Article 333. Li D, Pant S, Ryan DP, Laheru D, Bahary N, Dragovich T, Hosein PJ, Rolfe L, Saif MW, LaValle J, Yu KH, Lowery MA, Allen A, O'Reilly EM. A phase II, open-label, multicenter study to evaluate the antitumor efficacy of CO-1.01 as second-line therapy for gemcitabine-refractory patients with stage IV pancreatic adenocarcinoma and negative tumor hENT1 expression. Pancreatology. 2014 Sep-Oct;14(5):398-402. doi: 10.1016/j.pan.2014.07.003. Epub 2014 Jul 18. PMID: 25278310 [PubMed - in process] 334. Loughran TP, Jr., Zickl L, Olson TL, et al..Evens, AM Immunosuppressive therapy of LGL leukemia: prospective » » PUBLICATIONS multicenter phase II study by the Eastern Cooperative Oncology Group (E5998). Leukemia 2014 335. Macone AB, Caruso BK, Levy SB, et al. In Vitro and In Vivo Antibacterial Activities of Omadacycline, a Novel Aminomethylcycline. Antimicrobial Agents and Chemotherapy 2014;58(2):1127-1135. doi:10.1128/ AAC.01242-13 336. Marks E, Saif MW, Jia Y. Updates on first-line therapy for metastatic pancreatic adenocarcinoma. JOP. 2014 Mar 10;15(2):99-102. doi: 10.6092/1590-8577/2279. PMID: 24618427 [PubMed - indexed for MEDLINE] Free Article 337. Mathew P. The bifunctional role of steroid hormones: implications for therapy in prostate cancer. Oncology (Williston Park). 2014 May;28(5):397-404. Review. PMID: 25004653 338. Mathew P.The hemostatic system as a therapeutic target in urothelial carcinoma. Oncology (Williston Park). 2014 Oct;28(10):816, 830. PMID: 25323606 339. Merlini G, Comenzo RL, Seldin DC, Wechalekar A, Gertz MA. Immunoglobulin light chain amyloidosis. Expert Rev Hematol 2014;7:143-56. 340. N Brennan GT, Relias V, Saif MW. Novel agents for the treatment of pancreatic cancer. JOP. 2014 Mar 10;15(2):110-3. doi: 10.6092/1590-8577/2320. PMID: 24618430 [PubMed - indexed for MEDLINE] Free Article 341. Nabhan C, Aschebrook-Kilfoy B, Chiu BC, Kruczek K, Smith SM, Evens AM. The impact of race, age, and sex in follicular lymphoma: A comprehensive SEER analysis across consecutive treatment eras. American journal of hematology 2014;89:633-8. 342. Nabhan C, Aschebrook-Kilfoy B, Chiu BC, et al. The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia: a comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era. Leukemia & lymphoma 2014;55:2778-84. 343. Niazi AK, Kaley K, Saif MW. Gastrointestinal stromal tumor of colon: a case report and review of literature. Anticancer Res. 2014 May;34(5):2547-50. PMID: 24778074 [PubMed - indexed for MEDLINE] 344. Ocio EM, Richardson PG, Rajkumar SV, et al. New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG). Leukemia 2014;28:525-42. 345. Oh SY, Cunningham J, Saif MW. Colonic metastasis from gastric cancer. 346. Clin Colorectal Cancer. 2014 Dec;13(4):255-6. doi: 10.1016/j.clcc.2014.09.009. Epub 2014 Sep 21. No abstract available. PMID: 25442816 [PubMed - in process] 347. Oikonomopoulos GM, Syrigos KN, Skoura E, Saif MW. FOLFIRINOX: from the ACCORD study to 2014. JOP. 2014 Mar 10;15(2):103-5. doi: 10.6092/1590-8577/2278. PMID: 24618428 [PubMed - indexed for MEDLINE] Free Article 348. Pennarola BW, Rodday AM, Davies SM, Syrjala KL, Patel S, Bingen K, Kupst MJ, Schwartz L, Guinan EC, Mayer DK, Ratichek SJ, Hibbard JH, Parsons SK. Changing Factors Associated with Parent Activation in Pediatric Hematopoietic Stem Cell Transplant. Support Care Cancer 2014 (in press). 349. Puri A, Saif MW. Pharmacogenomics update in pancreatic cancer. JOP. 2014 Mar 10;15(2):114-7. doi: 10.6092/1590-8577/2285. PMID: 24618431 [PubMed - indexed for MEDLINE] Free Article

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 350. Puri A, Stevenson RL, Khouri J, Comenzo RL, Kao GSH, Klein AK, Miller KB, Rosenberg A, Smith H, Sprague KA, Relias V, Evens AM. Hepatitis B (HBV) Screening in Patients Receiving Rituximab: A Comprehensive Analysis Including Comparison of Adherence By Oncologists and Non-Oncologists. Blood (ASH): 2014; 124 (21): 2595. 351. Puzanov I, Sosman J, Santoro A, Saif MW, Goff L, Dy GK, Zucali P, Means-Powell JA, Ma WW, Simonelli M, Martell R, Chai F, Lamar M, Savage RE, Schwartz B, Adjei AA. Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors. Invest New Drugs. 2015 Feb;33(1):159-68. doi: 10.1007/ s10637-014-0167-5. Epub 2014 Oct 8. PMID: 25294187 [PubMed - in process] Free PMC Article 352. Puzanov I, Sosman J, Santoro A, Saif MW, Goff L, Dy GK, Zucali P, Means-Powell JA, Ma WW, Simonelli M, » » Martell R, Chai F, Lamar M, Savage RE, Schwartz B, Adjei AA., Phase 1 trial of tivantinib in combination with PUBLICATIONS sorafenib in adult patients with advanced solid tumors. Invest New Drugs. 2014. 353. Ramfidis VS, Psyrri A, Syrigos KN, Saif MW. First line treatment for metastatic pancreatic adenocarcinoma: looking for the step forward. JOP. 2014 Jul 28;15(4):286-8. doi: 10.6092/1590-8577/2622. PMID: 25076321 [PubMed - in process] Free Article 354. Reddy NM, Evens AM. Chemotherapeutic advancements in peripheral T-cell lymphoma. Seminars in hematology 2014;51:17-24. 355. Reece DE, Hegenbart U, Sanchorawala V, et al. Long-term follow-up from a phase 1/2 study of single-agent bortezomib in relapsed systemic AL amyloidosis. Blood. 2014;124:2498-506. 356. Relias V, Saif MW. Biological identification of ampullary adenocarcinomas. JOP. 2014 Jul 28;15(4):306-7. doi: 10.6092/1590-8577/2674. PMID: 25076327 [PubMed - in process] Free Article 357. Rizvi SM, Wong J, Saif MW, Jia Y. Pharmacogenetics in neuroendocrine tumors of the pancreas. JOP. 2014 Jul 28;15(4):299-302. doi: 10.6092/1590-8577/2659. PMID: 25076325 [PubMed - in process] Free Article 358. Rodday AM, Parsons SK, Correll CU, Robb AS, Zima BT, Saunders TS, Leslie LK. Child and Adolescent Psychiatrists’ Attitudes and Practices Prescribing Second Generation Antipsychotics. J Child Adolesc Psychopharmacol. 2014 Mar; 24(2):90-3. doi: 10.1089. PMID: 24679174, PMCID: PMC3967387 359. Saif MW, Lee AM, Offer SM, McConnell K, Relias V, Diasio RB. A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach. Mayo Clin Proc. 2014 Jan;89(1):131-6. doi: 0.1016/j.mayocp.2013.09.008. PMID: 24388031 [PubMed - indexed for MEDLINE] Free PMC Article 360. Rubin CL, Allukian N, Wang X, Ghosh S, Huang CC, Wang J, Brugge D, Wong JB, Mark S, Dong S, Koch-Weser S, Parsons SK, Leslie LK, Freud KM. We make the path by walking it: Building an academic community partnership with Boston’s Chinatown. Progress in Community Health Partnership 2014 January; 8(3): 353-63. DOI: 10.1353/ cpr.2014.0046. 361. Saif MW, Kaley K, Rodriguez T, Garcon MC. Gemcitabine as salvage treatment in patients with poorly differentiated pancreatic neuroendocrine tumors: a case series. JOP. 2014 Jan 10;15(1):38-41. doi: 10.6092/1590- 8577/1628. PMID: 24413782 [PubMed - indexed for MEDLINE] Free Article 362. Saif MW. Management of a patient with metastatic colorectal cancer and liver metastases. Case Rep Oncol Med. 2014;2014:790192. doi: 10.1155/2014/790192. Epub 2014 Mar 12. PMID: 24744930 [PubMed] Free PMC Article 363. Saif MW. MM-398 achieves primary endpoint of overall survival in phase III study in patients with gemcitabine refractory metastatic pancreatic cancer. JOP. 2014 May 27;15(3):278-9. doi: 10.6092/1590-8577/2507. No abstract available. PMID: 24865544 [PubMed - indexed for MEDLINE] Free Article 364. Saif MW, Ledbetter L, Kaley K, Garcon MC, Rodriguez T, Syrigos KN. Maintenance therapy with capecitabine in patients with locally advanced unresectable pancreatic adenocarcinoma. Oncol Lett. 2014 Sep;8(3):1302-1306. Epub 2014 Jun 11. PMID: 25120712 [PubMed] Free PMC Article

169 365. Saif MW. Advanced stage pancreatic cancer: novel therapeutic options. Expert Rev Clin Pharmacol. 2014 Jul;7(4):487-98. doi: 10.1586/17512433.2014.910451. PMID: 24939470 [PubMed - indexed for MEDLINE] 366. Saif MW. Antimetabolites. DeVita V, Hellman, Rosenberg S, Eds. In: Principles of Medical Oncology. Edition 10, 2014. 367. Saif MW, Relias V, Syrigos K, Gunturu KS. Incidence and management of ZIv-aflibercept related toxicities in colorectal cancer. World J Clin Oncol. 2014 Dec 10;5(5):1028-35. doi: 10.5306/wjco.v5.i5.1028. Review. PMID: 25493238 [PubMed] Free PMC Article

» 368. Salahuddin A, Saif MW. Pancreatic tuberculosis or autoimmune pancreatitis. Case Rep Med. 2014;2014:410142. » PUBLICATIONS doi: 10.1155/2014/410142. Epub 2014 Apr 15. PMID: 24839445 [PubMed] Free PMC Article 369. Saret CJ, Winn A, Shah G, Parsons SK, Lin PJ, Cohen JT, Neumann PJ. Value of Innovation in Leukemia, Lymphoma, and Myeloma: A Systematic Review. Blood 2014 (in press). 370. Schmoll HJ, Twelves C, Sun W, O'Connell MJ, Cartwright T, McKenna E, Saif M, Lee S, Yothers G, Haller D. Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: a pooled analysis of individual patient data from four randomised controlled trials. Lancet Oncol. 2014 Dec;15(13):1481-92. doi: 10.1016/S1470-2045(14)70486-3. Epub 2014 Nov 12. PMID: 25456367 [PubMed - indexed for MEDLINE] 371. Selker H, Oye K, Eichler, H, Stockbridge, N, Mehta, C, Kaitin, K,McElwee, N, Honig, P, Erban, J, D’Agostino, R. A Proposal for Integrated Efficacy-to-Effectiveness (E2E) Clinical Trials. Nature Clinical Pharmacology & Therapeutics 2014: 95 (2): 147–153. 372. Shah U, Kritharis A, Evens AM Paraneoplastic pyoderma gangrenosum with posttransplant lymphoproliferative disorder Annals of hematology2014 373. Stevenson R, Saif MW. Chapter – Immuntherapy for Pancreatic Cancer Prof. Nima Rezaei, Eds. In: Cancer Immunology: A Translational Medicine Context, Volume 3. 2014. Springer, Powell, WY, USA 374. Tejani MA, Saif MW. Pancreatic neuroendocrine tumors: does chemotherapy work? JOP. 2014 Mar 10;15(2):132- 4. doi: 10.6092/1590-8577/2301. PMID: 24618436 [PubMed - indexed for MEDLINE] Free Article 375. Terrin N, Rodday AM, Parsons SK. Joint Models for Predicting Transplant-Related Mortality from Quality of Life Data. Qual Life Res 2015; 24:31-39. doi: 10.1007/s11136-013-0550-2 [Epub ahead of print]. PMID: 24129669, PMCID: PMC3989470 376. Theochari MS, Syrigos KN, Saif MW. Biomarkers in pancreatic neuroendocrine tumors. JOP. 2014 Mar 10;15(2):138-9. doi: 10.6092/1590-8577/2321. PMID: 24618438 [PubMed - indexed for MEDLINE] Free Article 377. Toki MI, Syrigos KN, Saif MW. The role of biliary drainage in patients with pancreatic adenocarcinoma. JOP. 2014 Mar 10;15(2):128-31. doi: 10.6092/1590-8577/2292. PMID: 24618435 [PubMed - indexed for MEDLINE] Free Article 378. Toki MI, Syrigos KN, Saif MW. Risk determination for pancreatic cancer. JOP. 2014 Jul 28;15(4):289-91. doi: 10.6092/1590-8577/2591. PMID: 25076322 [PubMed - in process] Free Article 379. Tourkantonis IS, Peponi E, Syrigos KN, Saif MW. Pharmacogenetics in pancreatic cancer. JOP. 2014 Jul 28;15(4):335-9. doi: 10.6092/1590-8577/2689. PMID: 25076337 [PubMed - in process] Free Article 380. Valencia E, Saif MW. Neurofibromatosis type 1 and GIST: is there a correlation? Anticancer Res. 2014 Oct;34(10):5609-12. PMID: 25275063 [PubMed - indexed for MEDLINE]

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171 394. Rubin CL, Allukian N, Wang X, Ghosh S, Huang CC, Wang J, Brugge D, Wong JB, Mark S, Dong S, Koch-Weser S, Parsons SK, Leslie LK, Freund KM. “We make the path by walking it:” Building an academic community partnership with Boston Chinatown. Prog Community Health Partnersh. 2014 Fall;8(3):353-63. PMID: 25435562 395. Clark JA, Parker VA, Battaglia TA, Freund KM. Patterns of Task and Network Actions Performed by Navigators to Facilitate Cancer Care. Health Care Manage Rev. 2014 Apr-Jun; 39(2):90-101. PMID: 23478753 396. Wilkinson J, Lauer E, Greenwood NW, Freund KM, Rosen AK. Evaluating Representativeness and Cancer Screening Outcomes in a State Department of Developmental Services Database. Intellect Dev Disabil. 2014 Apr; 52(2):136-46. PMID: 24725112 » » PUBLICATIONS 397. Carle AC, Jean-Pierre P, Winters PC, Van Dyun MAS, Valverde P, Warren-Mears V, Wells K, Simon MA, Raich PC, Post D, Patierno SR, Katz M, Freund KM, Dudley DJ, Darnell J, Fiscella K. Psychometric Evaluation of the Patient Satisfaction with Logistical Aspects of Navigation (PSN-L) Scale Using Item Response Theory. Med Care. 2014 Apr; 52(4):354-61. PMID: 24848207 398. Gunn CM, Clark JA, Battaglia TA, Freund KM, Parker VA. An Assessment of Patient Navigator Activities in Breast Cancer Patient Navigation Programs Using a Nine-Principle Framework. Health Serv Res. 2014 May 13. PMID: 24820445 399. Gunn CM, Freund KM, Kaplan SA, Raj A, Carr PL. Knowledge and Perceptions of Family Leave Policies Among Female Faculty in Academic Medicine. Womens Health Issues. 2014 Mar-April; 24(2):e205-10. PMID: 24533979 PMCID: PMC3994529 400. Kapoor A, Battaglia TA, Isabelle AP, Hanchate A, Kalish RL, Bak S, Mishuris RG, Shroff S, Freund KM. The Impact of Health Insurance Coverage during Insurance Reform on Diagnostic Resolution of Cancer Screening Abnormalities. J Health Care Poor Underserved. 2014 Feb; 25(Suppl 1):109-21. PMID: 24583491 401. Freund KM, Isabelle AP, Hanchate A, Kalish RL, Kapoor A, Bak S, Mishuris RG, Shroff S, Battaglia TA. The Impact of Health Insurance Reform on Insurance Instability. J Health Care Poor Underserved. 2014 Feb; 25(Suppl 1):95- 108. PMID: 24583490 NIHMS ID: NIHMS623536 402. De La Cruz I, Freund KM, Battaglia TA, Chen CA, Bak S, Kalish R, Lottero B, Egan P, Heeren T, Kronman AC. Impact of Depression on the Intensity of Patient Navigation for Women with Abnormal Cancer Screenings. J Health Care Poor Underserved. 2014 Feb; 25(1):383-95. PMID: 24509033 PMCID: PMC4184058 403. Primeau SW, Freund KM, Ramachandran A, Bak SM, Heeren T, Chen CA, Morton S, Battaglia TA. Social Service Barriers Delay Care among Women with A normal Cancer Screening. J Gen Intern Med. 2014 Jan; 29(1):169-75. PMID: 24197626 PMCID: PMC3889949 404. Vedula R, Kopelman R, Rencic J. Complementary medicine. J Gen Intern Med. 2014;29:412-416.(Clinical reasoning series) 405. Yu EA, Snydman LK, Rencic J. Ramsay Hunt syndrome presenting with ataxia and syndrome of inappropriate antidiuretic hormone secretion. Am J Med 2014;127(12):e9-10. PMID: 25132348. 406. Botros J, Rencic J, Centor RM, Henderson M. Anchors away. J Gen Intern Med. 2014;29:1414-1418. (Clinical reasoning series) 407. Vedula R, Kopelman R, Rencic J. Complementary medicine. J Gen Intern Med. 2014;29:412-416.(Clinical reasoning series) 408. Yu EA, Snydman LK, Rencic J. Ramsay Hunt syndrome presenting with ataxia and syndrome of inappropriate antidiuretic hormone secretion. Am J Med 2014;127(12):e9-10. PMID: 25132348.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 409. Shields HM, Stoffel EM, Chung DC, Sequist TD, Li JW, Pelletier SR, Spencer J, Silk JM, Austin BL, Diguette S, Furbish JE, Lederman R, Weingart SN. Disparities in evaluation of patients with rectal bleeding 40 years and older. Clin Gastroenterol Hepatol 2014; 12:669-75. 410. Weingart SN, Zhu J, Young-Hong J, Barr Vermilya H, Hassett M. Do drug interaction alerts between a chemotherapy order-entry system and an electronic medical record affect clinician behavior? J Oncol Pharm Pract 2014;20:163-71. 411. Weissman JS, Lopez L, Schneider EC, Epstein AM, Lipsitz S, Weingart SN. The association of hospital quality ratings with adverse events. Int J Qual Health Care 2014; 26:129-35. » » 412. Bunnell C, Losk K, Kadish S, Lin N, Hirshfield-Bartek J, Cutone L, Camuso K, Golshan M, Weingart S. Measuring PUBLICATIONS opportunities to improve the timeliness of breast cancer care at Dana-Farber/Brigham and Women’s Cancer Center. J Natl Compr Canc Netw 2014;12:S-5-S-9. 413. Zhu J, Li L, Zhao H, Han G, Wu AW, Weingart SN. Development of a patient safety climate for Chinese hospitals: cross-national adaptation and psychometric evaluation. BMJ Qual Saf 2014;23:847-56. 414. Weingart SN, Hsieh C, Lane S, Cleary A. Standardizing central venous catheter care by using observations from patients with cancer. Clin J Oncol Nurs 2014;18:321-6. 415. Okoroh JS, Uribe EF, Weingart SN. Racial and ethnic disparities in patient safety. J Patient Safe 2014 Aug 12. [Epub ahead of print] 416. Abookire SA, Gandhi TK, Kachalia A, Sands K, Mort E, Bommarito G, Gagne J, Sato L, Weingart SN. Creating a fellowship curriculum in patient safety and quality. Am J Med Qual 2014 Sept 2. [Epub ahead of print] 417. Gandhi TK, Abookire SA, Kachalia A, Sands K, Mort E, Bommarito G, Gagne J, Sato L, Weingart SN. Design and implementation of the Harvard fellowship in patient safety and quality. Am J Med Qual, 2014 Sept 2. [Epub ahead of print] 418. Golshan M, Losk K, Camuso K, Hirshfield-Bartek J, Cutone L, Lin N, Sagara Y, Aydogan F, Kadish S, Weingart SN, Bunnell C. Understanding process-of-care delays in surgical treatment of breast cancer at a comprehensive cancer center. Breast Cancer Res Treat 2014;148:125-33. 419. Weingart SN. Implementing practice guidelines: easier said than done [commentary]. Isr J Health Policy Res 2014 3:20. Division of Nephrology 420. Adrogue HJ, Madias NE. The impact of sodium and potassium on hypertension risk. Semin Nephrol 2014;34:257- 72. Epub 2014 Apr 8;PMID:25016398. 421. Adrogue HJ, Madias NE. Diagnosis and treatment of hyponatremia. Am J Kidney Dis 2014;64:681-4. Epub 2014 Jul 2;PMID:24996937.

173 422. Adrogue HJ, Madias NE. Sodium surfeit and potassium deficit: keys to the pathogenesis of hypertension: J Am Soc Nephrol 2014;8:203-13. Epub 2013 Nov 4;PMID:24200471. 423. Alqahtani F, Koulouridis I, Susantitaphong P, Dahal K, Jaber BL. A meta-analysis of continuous vs intermittent infusion of loop diuretics in hospitalized patients. J Crit Care 2014;29:10-7. Epub 2013 May 14;PMID:23683555. 424. Brown JR, Katz R, Ix JH, de Boer IH, Siscovick DS, Grams ME, Shlipak M, Sarnak MJ. Fibroblast growth factor-23 and the long-term risk of hospital-associated AKI among community-dwelling older individuals. Clin J Am Soc Nephrol 2014;9:239-46. Epub 2013 Nov 21;PMID:24262510.

» 425. Brown JR, Solomon RJ, Sarnak MJ, McCullough PA, Splaine ME, Davies L, Ross CS, Dauerman HL, Stender JL, » PUBLICATIONS Conley SM, Robb JF, Chaisson K, Boss R, Lambert P, Goldberg DJ, Lucier D, Fedele FA, Kellett MA, Horton S, Phillips WJ, Downs C, Wiseman A, MacKenzie TA, Malenka DJ;Northern New England Cardiovascular Disease Study Group. Reducing contrast-induced acute kidney injury using a regional multicenter quality improvement intervention. Circ Cardiovasc Qual Outcomes 2014;7:693-700. Epub 2014 Jul 29;PMID:25074372.. 426. Cohen-Bucay A, Garimella P, Ezeokonkwo C, Bijol V, Strom JA, Jaber BL. Acute oxalate nephropathy associated with Clostridium difficile colitis. Am J Kidney Dis 2014;63:113-8. Epub 2013 Oct 30;PMID:24183111. 427. Coresh J, Turin TC, Matsushita K, Sang Y, Ballew SH, Appel LJ, Arima H, Chadban SJ, Cirillo M, Djurdjev O, Green JA, Heine GH, Inker LA, Irie F, Ishani A, Ix JH, Kovesdy CP, Marks A, Ohkubo T, Shalev V, Shankar A, Wen CP, de Jong PE, Iseki K, Stengel B, Gansevoort RT, Levey AS; CKD Prognosis Consortium. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA 2014;311:2518-31. PMID:24892770. 428. Crews DC, Scialla JJ, Boulware LE, Navaneethan SD, Nally JV Jr, Liu X, Arrigain S, Schold JD, Ephraim PL, Jolly SE, Sozio SM, Michels WM, Miskulin DC, Tangri N, Shafi T, Wu AW, Bandeen-Roche K; DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators. Comparative effectiveness of early versus conventional timing of dialysis initiation in advanced CKD. Am J Kidney Dis 2014;63:805-15. Epub 2014 Feb 6;PMID:24508475. 429. Crews DC, Scialla JJ, Liu J, Guo H, Bandeen-Roche K, Ephraim PL, Jaar BG, Sozio SM, Miskulin DC, Tangri N, Shafi T, Meyer KB, Wu AW, Powe NR, Boulware LE; for the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Patient Outcomes in End Stage Renal Disease Study Investigators. Predialysis health, dialysis timing, and outcomes among older United States adults. J Am Soc Nephrol 2014;25:370-9. Epub 2013 Oct 24;PMID:24158988. 430. Darsie B, Shlipak MG, Sarnak MJ, Katz R, Fitzpatrick AL, Odden MC. Kidney function and cognitive health in older adults: the Cardiovascular Health Study. Am J Epidemiol 2014;180:68-75. Epub 2014 May 20;doi:10.1093/ aje/kwu102;PMID:24844846. 431. Drew DA, Sarnak MJ. Ischemic and hemorrhagic stroke: high incidence in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 2014;63:547-8. doi:10.1053/j.ajkd.2014.01.009;PMID:24670482. 432. Drew DA, Tighiouart H, Scott T, Kantor A, Fan L, Artusi C, Plebani M, Weiner DE, Sarnak MJ. Asymmetric dimethylarginine, race, and mortality in hemodialysis patients. Clin J Am Soc Nephrol 2014;9:1426-33. Epub 2014 Jun 26;PMID:24970872. 433. Drew DA, Tighiouart H, Scott TM, Lou KV, Fan L, Shaffi K, Weiner DE, Sarnak MJ. FGF-23 and cognitive performance in hemodialysis patients. Hemodial Int 2014;18:78-86. Epub 2013 Oct 24;PMID:24164913. 434. Drew DA, Weiner DE. Cognitive impairment in chronic kidney disease: keep vascular disease in mind. Kidney Int 2014;85:505-7. PMID:24583984.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 435. Driver TH, Katz R, Ix JH, Magnani JW, Peralta CA, Parikh CR, Fried L, Newman AB, Kritchevsky SB, Sarnak MJ, Shlipak MG; Health ABC Study. Urinary kidney injury molecule 1 (KM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Kidney Dis 2014;64:49-56. Epub 2014 Mar 18;doi:10.1053/j.ajkd.2014.01.432;PMID:24656453. 436. Driver TH, Shlipak MG, Katz R, Goldenstein L, Sarnak MJ, Hoofnagle AN, Siscovick DS, Kestenbaum B, de Boer IH, Ix JH. Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 2014;64:534-41. Epub 2014 Jun 18;PMID:24953891. 437. Fan L, Inker LA, Rossert J, Froissart M, Rossing P, Mauer M, Levey AS. Glomerular filtration rate estimation using » » cystatin C alone or combine with creatinine as a confirmatory test. Neph Dial Transplant 2014;29:1195-1203. PUBLICATIONS Epub 2014 Jan 20;PMID:24449101. 438. Fan L, Sarnak MJ, Tighiouart H, Drew DA, Kantor AL, Lou KV, Sharri K, Scott TM, Weiner DE. Depression and all-cause mortality in hemodialysis patients. Am J Nephrol 2014;40:12-8. Epub 2014 Jun 24;PMID:24969267. 439. Fan L, Tighiouart H, Levey AS, Beck GJ, Sarnak MJ. Urinary sodium excretion and kidney failure in nondiabetic chronic kidney disease. Kidney Int 2014;86:582-8. Epub 2014 Mar 9;doi:10.1038/ki.2014.59;PMID:24646858. 440. Foster MC, Rawlings AM, Marrett E, Neff D, Grams ME, Kasiske BL, Willis K, Inker LA, Coresh J, Selvin E. Potential effects of reclassifying CKD as coronary heart disease risk equivalent in the US population. Am J Kidney Dis 2014;63:753-60. Epub 2013 Dec 23;PMID:24369751. 441. Garimella PS, Ix JH, Katz R, Chonchol MB, Kestenbaum BR, de Boer IH, Siscovick DS, Shastri S, Hiramoto JS, Shlipak MG, Sarnak MJ. Fibroblast growth factor 23, the ankle-brachial index, and incident peripheral artery disease in the Cardiovascular Health Study. Atherosclerosis 2014;233:91-6. Epub 2014 Jun 4;PMID:2459128. 442. Garimella PS, Hirsch AT. Peripheral artery disease and chronic kidney disease. Adv Chronic Kidney Dis 2014; 21:460-71. 443. Gilbert SJ and Weiner DE (Eds). National Kidney Foundations Primer on Kidney Disease. 6th Edition, Elsevier, Philadelphia, 2014. 444. Goldstein L, Driver TH, Fried LF, Rifkin DE, Patel KV, Yenchek RH, Harris TB, Kritchevsky SB, Newman AB, Sarnak MJ, Shlipak MG, Ix JH; Health ABC Study Investigators. Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging and Body Composition (Health ABC) Study. Am J Kidney Dis 2014;64:542-9. Epub 2014 Jun 18;doi:10.1053/j.ajkd.2014.05.009;PMID:24953890. 445. Greene T, Teng CC, Inker LA, Redd A, Ying J, Woodard M, Coresh J, Levey AS. Utility and validity of estimated GFR-based surrogate time-to-event points in CKD: a simulation study. Am J Kidney Dis 2014;64:867-79. Epub 2014 Oct 31;PMID:25441440. 446. Grubbs V, Moss AH, Cohen LM, Fischer MJ, Germain MJ, Jassal SW, Perl J, Weiner DE, Mehrotra R; on behalf of the Dialysis Advisory Group of the American Society of Nephrology. A palliative approach to dialysis care: a patient-centered transition to the end of life. Clin J Am Soc Nephrol 2014; 9:2203-9. Epub 2014 Aug 7; pii:CJN.006550114; PMID:24104274. 447. Guay-Woodfod LM, Henske E, Igarshi P, Perrone RD, Reed-Gitomer B, Somlo S, Torres VE, Ketchum CJ, Star RA, Flessner MF, Rasooly RS. Filling the holes in cystic kidney disease research. Clin J Am Soc Nephrol 2014;9:1799- 1801. Epub 2014 Jun 5;PMID:24903391. 448. Inker LA. Albuminuria: time to focus on accuracy. Am J Kidney Dis 2014;63:378-81. PMID:24560154.

175 449. Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, Kurella Tamura M, Feldman HI. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis 2014;63:713-35. Epub 2014 Mar 16;PMID:24647050. 450. Inker LA, Lambers Heerspink HJ, Mondal H, Schmid CH, Tighiouart H, Noubary F, Coresh J, Greene T, Levey AS. GFR decline as an alternative end point to kidney failure in clinical trials: a meta-analysis of treatment effects from 37 randomized trials. Am J Kidney Dis 2014;64:848-59. Epub 2014 Oct 16;PMID:25441437. 451. Inker LA, Levey AS, Pandya K, Stoycheff N, Okparavero A, Greene T; Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Early change in proteinuria as a surrogate end point for kidney disease progression: an » » PUBLICATIONS individual patient meta-analysis. Am J Kidney Dis 2014;64:74-85. Epub 2014 Apr 29;PMID:24787763. 452. Jessani S, Levey AS, Box R, Inker LA, Islam M, Chaturvedi N, Mariat C, Schmid CH, Jafar TH. Estimation of GFR in South Asians: a study from the general population in Pakistan. Am J Kidney Dis 2014;63:49-58. Epub 2013 Sept 26;PMID:24074822. 453. Kanbay M, Solak Y, Gaipov A, Takir M, Weiner DE. Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality. Blood Purif 2014;37:172-8. Epub 2014 May 27;PMID:24903910. 454. Kim DH, Grodstein F, Newman AB, Chaves PH, Odden MC, Klein R, Sarnak MJ, Patel KV, Lipsitz LA. Prognostic implications of microvascular and macrovascular abnormalities in older adults: cardiovascular health study. J Gerontol A Biol Sci Med 2014;69:1495-502. Epub 2014 May 25;doi:10.1093/Gerona/glu074;PMID:2484308. 455. Koyner JL, Cerda J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S; Acute Kidney Injury Advisory Group of the American Society of Nephrology. The daily burden of acute kidney injury: a survey of the US nephrologists on World Kidney Day. Am J Kidney Dis 2014;64:394-401. Epub 2014 May 9;PMID: 24815216. 456. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med 2014;371:2309-19. PMID:25494270. 457. Lambers Heerspink HJ, Tighiouart H, Sang Y, Ballew S, Mondal H, Matsushita K, Coresh J, Levey AS, Inker LA. GFR decline and subsequent risk of established kidney outcomes: a meta-analusis of 37 randomized controlled trials. Am J Kidney Dis 2014;64:860-6. Epub 2014 Oct 16;PMID:25441439. 458. Lambers Heerspink HJ, Weldegiorgis M, Inker LA, Gansevoort R, Parving HH, Dwyer JP, Mondal H, Coresh J, Greene T, Levey AS, de Zeeuw D. Estimated GFR decline as a surrogate end point for kidney failure: a post hoc analysis from the Reduction of End Points in Non-Insulin-Dependent Diabetes with the Angiotension II Antagonist Losartan (RENAAL) Study and Irbesartan Diabetic Nephropathy Trial (IDNT). Am J Kidney Dis 2014;63:244-50. Epub 2013 Nov 6;PMID:24210590. 459. Levey AS, Fan L, Eckfeldt JH, Inker LA. Cystatin C for glomerular filtration rate estimation: coming of age. Clin Chem 2014;60:916-9. Epub 2014 May 28;PMID:24871681. 460. Levey AS, Inker LA, Coresh J. GFR estimation: from physiology to public health. Am J Kidney Dis 2014;63:820-34. Epub Jan 28;PMID:24485147. 461. Levey AS, Inker LA, Matsushita K, Greene T, Willis K, Lewis E, de Zeeuw D, Cheung AK, Coresh J. GFR decline as an end point for clinical trials in CKD: a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration. Am J Kidney Dis 2014;64:821-35. Epub 2014 Oct 16;PMID:25441437. 462. Levey AS, Shaffi K, Inker LA. In reply to “Creatinine-based GFR estimating equations in kidney transplant recipients” and “Assessing kidney function in transplant recipients: time to work together and address the most relevant questions.” Am J Kidney Dis 2014;64:819. PMID:25344002.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 463. Menon V, Rao M. Interactions of a low molecular weight inhibitor from Streptomyces sp. MBR04 with human cathepsin D: implications in mechanism of inactivation. Appl Biochem Biotechnol 2014;174:1705-23. Epub 2014 Aug 21;PMID:25141983. 464. Miskulin DC, Abebe KZ, Chapman AB, Perrone RD, Steinman TI, Torres VE, Bae KT, Braun W, Winklhofer FT, Hogan MC, Rahbari-Oskoui F, Moore CG, Flessner MF, Schrier RW;HALT-PKD Study. Health-related quality of life in patients with autosomal dominant polycystic kidney disease and CKD stages 1-4: a cross-sectional study. Am J Kidney Dis 2014;63:214-26. Epub 2013 Oct 31;PMID:24183837. 465. Miskulin DC, Tangri N, Bandeen-Roche K, Zhou J, McDermott A, Meyer KB, Ephraim PL, Michels WM, Jaar BG, » » Crews DC, Scialla JJ, Sozio SM, Shafi T, Wu AW, Cook C, Boulware LE; Developing Evidence to Inform Decisions PUBLICATIONS about Effectiveness (DEcIDE) Network Patient Outcomes in End Stage Renal Disease Study Investigators. Intravenous iron exposure and mortality in patients on hemodialysis. Clin J Am Soc Nephrol 2014;9:1930-9. Epub 2014 Oct 15;PMID:25318751. 466. Odden MC, Shlipak MG, Whitson HE, Katz R, Kearney PM, Defilippi C, Shastri S, Sarnak MJ, Siscovick DS, Cushman M, Psaty BM, Newman AB. Risk factors for cardiovascular disease across the spectrum of older age: The Cardiovascular Health Study. Atherosclerosis 2014;237:336-42. Epub 2014 Sep 30;PMID:25303772. 467. Pierro ML, Kainerstorfer JM, Civiletto A, Weiner DE, Sassaroli A, Hallacoglu B, Fantini S. Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study. J Biomed Opt 2014;19:026005. doi: 10.1117/1.JBO.19.2.026005. 468. Samaniego M, Perrone RD. Living donor transplantation: should we advocate for it? Nephrol News Issues 2014;28:22-3;PMID:24649751. 469. Sarnak MJ. A patient with heart failure and worsening kidney function. Clin J Am Soc Nephrol 2014;9:1790-8. Epub 2014 Apr 24;doi:10.2215/CJN.11601113;PMID:24763864. 470. Sarnak MJ, Katz R, Newman A, Harris T, Peralta CA, Devarajan P, Bennett MR, Fried L, Ix JH, Satterfield S,. Siomnsick EM, Parikh CR, Shlipak MG; Health ABC Study. Association of urinary injury biomarkers with mortality and cardiovascular events. J Am Soc Nephrol 2014;25:1545-53. Epub 2013 Feb 7;PMID:24511130. 471. Schrier RW, Abebe KZ, Perrone RD, Torres VE, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czamecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Bae KT, Moore CG, Chapman AB; the HALT-PKD Trial Investigators. Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med 2014; 371:2255-66. Epub 2014 Nov 15; PMID:25399733. 472. Scialla JJ, Liu J, Crews DC, Guo H, Bandeen-Roche K, Ephraim PL, Tangri N, Sozio SM, Shafi T, Miskulin DC, Michels WM, Jaar BG, Wu AW, Powe NR, Boulware LE; DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators. An instrumental variable approach finds no associated harm or benefit with early dialysis initiation in the United States. Kidney Int 2014;86:798-809. Epub 2014 Apr 30;PMID:24786707. 473. Shaffi K, Uhlig K, Perrone RD, Ruthazer R, Rule A, Lieske JC, Navis G, Poggio ED, Inker LA, Levey AS. Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients. Am J Kidney Dis 2014;63:1007-18. Epub 2014 Apr 2;PMID:24703720. 474. Shafi T, Sozio SM, Bandeen-Roche KJ, Ephraim PL, McDermott A, Scialla JJ, Crews DC, Tangri N, Miskulin DC, Michels WM, Jaar BG, Herzog CA, Zager PG, Meyer KB, Wu AW, Boulware LE; DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators. Predialysis systolic BP variability and outcomes in hemodialysis patients. J Am Soc Nephrol 2014;25:799-809. Epub 2014 Jan 2;PMID:24385593.

177 475. Shaffi K, Uhlig K, Perrone RD, Ruthazer R, Rule A, Lieske JC, Navis G, Poggio ED, Inker LA, Levey AS. Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients. Am J Kidney Dis 2014;63:1007-18. Epub 2014 Apr 2;PMID:24703720. 476. Sud M, Tangri N, Pintilie M, Levey AS, Naimark DM. Risk of end-stage renal disease and death after cardiovascular events in chronic kidney disease. Circulation 2014;130:450-65. Epub 2014 Jun 4;PMID:24899688. 477. Sud M, Tangri N, Levin A, Pintilie M, Levey AS, Naimark DM. CKD stage at nephrology referral and factors influencing the risks of ESRD and death. Am J Kidney Dis 2014;63:928-36. Epub 2014 Jan 28;PMID:24485146.

» 478. Susantitaphong P, Alqahtani F, Jaber BL. Efficacy and safety of intravenous iron therapy for functional iron » PUBLICATIONS deficiency anemia in hemodialysis patients: a meta-analysis. Am J Kidney Dis 2014;39:130-41. Epub 2014 Feb 7;PMID:24513913. 479. Susantitaphong P, Jaber BL. Understanding discordant meta-analysis of convective dialytic therapies for chronic kidney failure. Am J Kidney Dis 2014;63:888-91. PMID:24856616. 480. Torres VE, Abebe KZ, Chapman AB, Schrier RW, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czamecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Moore CG, Perrone RD; the HALT-PKD Trial Investigators. Angiotensin blockade in late autosomal dominant polycystic kidney disease. N Engl J Med 2014; 371:2267-2276. Epub 2014 15 Nov; PMID:25399731. 481. Tsai CW, Grams ME, Inker LA, Coresh J, Selvin E. Cystatin C- and creatinine-based estimated glomerular filtration rate, vascular disease, and mortality in persons with diabetes in the United States. Diabetes Care 2014;37:1002-8. Epub 2013 Nov 22;PMID:24271191. 482. Weiner DE, Brunelli SM, Hunt A, Schiller B, Glassock R, Maddux FW, Johnson D, Parker T, Nissenson A. Improving clinical outcomes among hemodialysis patients: a proposal for “Volume First” approach from the Chief Medical Officers of US Dialysis Providers. Am J Kidney Dis 2014;64:685-95. Epub 2014 Aug 22;PMID:25156305. 483. Weiner DE, Seliger SL. Cognitive and physical function in chronic kidney disease. Curr Opin Nephrol Hypertens 2014;23:291-7. PMID:24638060. 484. Weiner DE, Tighiouart H. In reply to “Etiological versus prognostic models in cohort studies” and “Nutritional supplement use in hemodialysis patients”. Am J Kidney Dis 2014;63:1068. PMID:24856621. 485. Weiner DE, Tighiouart H, Ladik V, Meyer KB, Zager PG, Johnson DS. Oral intradialytic nutritional supplement use and mortality in hemodialysis patients. Am J Kidney Dis 2014;63:276-85. Epub 2013 Oct 3;PMID:24094606. 486. Weiner DE, Winkelmayer WC. Commentary on “The DOPPS practice monitor for US dialysis care: potential impact of recent guidelines and regulatory changes on management of mineral and bone disorder among US hemodialysis patient”: the calm before the 2016 storm? Am J Kidney Dis 2014;63:854-8. PMID:24725918. 487. Weiner D E and Sarnak M J: Cardiovascular Considerations in Dialysis, in Daugirdas JT, Blake PG and Ing TS (ed): Handbook of Dialysis (ed 5), chap 33. Philadelphia, PA, Lippencott Williams & Wilkins, 2014. 488. Wen CP, Matsushita K, Coresh J, Iseki K, Islam M, Katz R, McClellan W, Peralta CA, Wang H, de Zeeuw D, Astor BC, Gansevoort RT, Levey AS, Levin A; Chronic Kidney Disease Prognosis Consortium. Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar. Kidney Int 2014;86:819-27. Epub 2014 Jan 28;PMID:24522492. Division of Pulmonary, Critical Care and Sleep Medicine 489. Al-Naamani N, Roberts KE, Hill NS, Preston IR. Imatinib as rescue therapy in a patient with pulmonary hypertension associated with Gaucher disease. Chest 2014;146:e81-3.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 490. Al-Qadheeb NS, Balk EM, Fraser GL, Skrobik Y, Riker RR, Kress JP, Whitehead S, Devlin JW. Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. Crit Care Med 2014;42:1442-54. 491. Angus DC, Deutschman CS, Hall JB, Wilson KC, Munro CL, Hill NS. Choosing wisely® in critical care: maximizing value in the intensive care unit. Am J Crit Care 2014;23:444-5. 492. Batra S, Machicaso VI, Bynon JS, Mehta S, Tanikella R, Krowka MJ, Zacks S, Trotter J, Roberts KE, et al. Pulmonary vascular complications of liver disease group; the impact of left ventricular hypertrophy on survival in candidates for liver transplantation. Liver Transpl 2014;20:705-12. » » 493. Bioc JJ, Magee C, Cucchi J, Fraser GL, Dasta JF, Edwards RA, Devlin JW. Cost effectiveness of a benzodiazepine vs. PUBLICATIONS a nonbenzodiazepine-based sedation regimen for mechanically ventilated, critically ill adults. J Crit Care 2014;29:753-7. 494. Blanco MA, Maderer A, Oriel A, Epstein SK. How we launched a developmental student-as-teacher (SAT) program for all medical students. Med Teach 2014;36:385-9. 495. Budhiraja R, Siddiqi TA, Quan SF. Sleep disorders in chronic obstructive pulmonary disease: etiology, impact and management. J Clin Sleep Med 2014 (in press) 496. Chaulagain CP, Pilichowska M, Brinckerhoff L, Tabba M, Erban JK. Secondary pulmonary alveolar proteinosis in hematologic malignancies. Hematol Oncol Stem Cell Ther 2014;7:127-35. 497. Chung L, Domsic RT, Lingala B, Alkassab F, Bolster M, Csuka ME, Derk C, Fischer A, Frech T, Furst DE, Gomberg- Maitland M, Hinchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TA, Molitor JA, Preston IR et al. Survival and predictors of mortality in systemic sclerosis-associated pulmonary arterial hypertension: outcomes from the pulmonary hypertension assessment and recognition of outcomes in scleroderma registry. Arthritis Care Res 2014;66:489-95. 498. D’Ambrosio CM. The multifaceted origins of sleep-disordered breathing. Clin Chest Med 2014;35:xiii-xiv. 499. Devlin JW, Al-Qadheeb NS, Chi A, Roberts R, Qawi I, Garpestad E, Hill NS. Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double-blind, placebo-controlled pilot study. Chest 2014;145:1204-12. 500. Devlin JW. The author replies. Crit Care Med 2014;42:e810. 501. Devlin JW, Pohlman AS. Everbody, every day: an “awakening and breathing coordination, delirium monitoring/ management, and early exercise/mobility” culture is feasible in your ICU. Crit Care Med 2014;42:1280-1. 502. Devlin JW, Zaal IJ, Slooter AJ. Clarifying the confusion surrounding drug-associated delirium in the ICU. Crit Care Med 2014;42:1565-6. 503. DiRaimondo TR, Klock C, Warburton R, Herrera Z, Penumatsa K, Toksoz D, Hill N, Khosla C, Fanburg B. Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice. ACS Chem Biol 2014;9:266-75. 504. Dweik RA, Rounds S, Erzurum SC, Archer S, Fagan K, Hassoun PM, Hill NS et al. ATS Committee on Pulmonary Hypertension Phenotypes. An official American Thoracic Society Statement: pulmonary hypertension phenotypes. Chest 2014;145:1204-12. 505. Gagnon DJ, Roberts R, Sylvia L. Implementation of the systems approach to improve a pharmacist-managed vancomycin dosing service. 2014;71:2080-4. 506. Galie N, Corris PA, Frost A, Girgis RE, Granton J, Jing ZC, Klepetko W, McGoon MD, McLaughlin VV, Preston IR et al. Updated treatment algorithm of pulmonary arterial hypertension. Turk Kardiyol Dern Ars 2014;42 Suppl 1:78-94.

179 507. Kaput NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS et al. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc 2014;229:1484-93. 508. Khan WH, Mohsenin V, D’Ambrosio CM. Sleep in asthma. Clin Chest Med 2014;35:483-93. 509. Liesching T, Nelson DL, Cormier KL, Sucov A, Short K, Warburton R, Hill NS. Randomized trial of bilevel versus continuous positive airway pressure for acute pulmonary edema. J Emerg Med 2014;46(1):130-40. 510. Lindenauer PK, Stefan MS, Shieh MS, Pekow PS, Rothberg MC, Hill NS. Outcomes associated with invasive and

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TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Division of Rheumatology 523. Bannuru RR, Vaysbrot EE, Sullivan MC, McAlindon TE. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis. A systematic review and meta-analysis. Seminars in Arthritis and Rheumatism 2014; 43(5):593:9. [PMID: 24216297] 524. Bannuru RR, Vaysbrot EE, McIntyre LF. Did the American Academy of Orthopedic Surgeons osteoarthritis guidelines miss the mark? Arthroscopy: The Journal of Arthroscopic & Related Surgery 2014; 30(1):86-9. [PMID: 24384274] »

525. Bannuru RR, McAlindon TE, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin » PUBLICATIONS Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. OARSI Guidelines for the Non-Surgical Management of Knee Osteoarthritis. Osteoarthritis and Cartilage 2014; 22(3):363-88. [PMID: 24462672]. 526. Bannuru RR, Sullivan MC, Manning E. Yoga for Rheumatic Conditions: Potential Physical, Cognitive and Affective Advantages. J Yoga Phys Ther 2014; 4: 160. 527. Bannuru RR, Flavin NE, Vaysbrot EE, Harvey W, McAlindon TE. High-energy extracorporeal shock wave therapy for treating chronic calcific tendonitis of the shoulder: a systematic review. Annals of Internal Medicine 2014; 160(8):542-9. [PMID: 24733195]. 528. Driban JB, Zhang FF, Lo GH, Price LL, Booth S, Eaton CB, Lu B, Nevitt M, Jackson B, Garganta C, Hochberg MC, Kwoh K, McAlindon TE. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014 Dec;144(12):2002-8. doi: 10.3945/jn.114.193227. 529. Driban JB, Wang C, Iversen MD, McAlindon T, Harvey WF, Wong JB, Fielding RA, Price LL, Rones R, Gamache T, Schmid CH. Assessing the comparative effectiveness of Tai Chi versus physical therapyfor knee osteoarthritis: design and rationale for a randomized trial. BMC Complement Altern Med. 2014 Sep 8;14:333. doi: 10.1186/1472-6882-14-333. 530. Driban JB, Zhang M, Price LL, Harper D, Lo GH, Miller E, Ward RJ, McAlindon TE. Development of a rapid knee cartilage damage quantification method using magnetic resonance images. BMC Musculoskelet Disord. 2014 Aug 6;15:264. doi: 10.1186/1471-2474-15-264. 531. Driban J, Pang J, McAlindon T, Tamez-Pena J, Fripp J, Miller E. On the use of coupled shape priors for segmentation of magnetic resonance images of the knee. IEEE J Biomed Health Inform. 2014 Jun 30. [Epub ahead of print] 532. Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B, McAlindon TE. Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2014 Nov;66(11):1673-9. doi: 10.1002/acr.22359. 533. Driban JB, Barbe MF, Amin M, Kalariya NS, Zhang M, Lo GH, Tassinari AM, Harper D, Price LL, Eaton CB, Schneider E, McAlindon TE. Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees. BMC Musculoskelet Disord. 2014 Apr 29;15:143. doi: 10.1186/1471-2474-15-143. 534. Driban JB, Lu B, Duryea J, McAlindon T, Lapane KL, Eaton CB. Milk consumption and progression of medial tibiofemoral knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2014 Jun;66(6):802-9. doi: 10.1002/acr.22297.

181 535. Kalish RA, Navarro-Zarza JE, Hernandez-Díaz C, Saavedra MA, Alvarez-Nemegyei J, Canoso JJ, Villaseñor-Ovies P. Pre-workshop knowledge of musculoskeletal anatomy of rheumatology fellows and rheumatologists of seven North, Central and South American Countries. Arthritis Care Res, 2014; 66 (2):270-276 536. Kalish R, McDonald G, Vannier A, Weinkauf C, Danic I, Pilichowska-Roehling M, Shinkura R, Selsing E, Imanishi- Kari T. Anti-DNA and RNA autoantibodies in the etiopathogenesis of SLE; (Abstract #2023). Presented at the Keystone Symposia on Autoimmunity and Tolerance, February 5, 2014, Keystone, CO. 537. McAlindon TE, Zhang FF, Driban JB, Lo GH, Price LL, Booth S, Eaton CB, Lu B, Nevitt M, Jackson B, Garganta C, Hochberg MC, Kwoh K. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014 » » PUBLICATIONS Dec;144(12):2002-8. doi: 10.3945/jn.114.193227. 538. McAlindon T, Wang C, Iversen MD, Harvey WF, Wong JB, Fielding RA, Driban JB, Price LL, Rones R, Gamache T, Schmid CH. Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial. BMC Complement Altern Med. 2014 Sep 8;14:333. doi: 10.1186/1472-6882-14-333. 539. McAlindon T, Zhang M, Driban JB, Price LL, Harper D, Lo GH, Miller E, Ward RJ. Development of a rapid knee cartilage damage quantification method using magnetic resonance images. BMC Musculoskelet Disord. 2014 Aug 6;15:264. doi: 10.1186/1471-2474-15-264. 540. McAlindon T, Pang J, Driban J, Tamez-Pena J, Fripp J, Miller E. On the use of coupled shape priors for segmentation of magnetic resonance images of the knee. IEEE J Biomed Health Inform. 2014 Jun 30. [Epub ahead of print] 541. McAlindon TE, Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B. Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2014 Nov;66(11):1673-9. doi: 10.1002/acr.22359. 542. McAlindon TE, Driban JB, Barbe MF, Amin M, Kalariya NS, Zhang M, Lo GH, Tassinari AM, Harper D, Price LL, Eaton CB, Schneider E. Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees. BMC Musculoskelet Disord. 2014 Apr 29;15:143. doi: 10.1186/1471-2474-15-143. 543. McAlindon T, Lu B, Driban JB, Duryea J, Lapane KL, Eaton CB. Milk consumption and progression of medial tibiofemoral knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2014 Jun;66(6):802-9. doi: 10.1002/acr.22297. 544. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. Response to Letter to the Editor entitled "Comments on 'OARSI guidelines for the non-surgical management of knee osteoarthritis'". Osteoarthritis Cartilage. 2014 Jun;22(6):890-1. doi: 10.1016/j.joca.2014.04.001. Epub 2014 Apr 15. No abstract available. 545. McAlindon T, Bannuru RR, Flavin NE, Vaysbrot E, Harvey W,. High-energy extracorporeal shock-wave therapy for treating chronic calcific tendinitis of the shoulder: a systematic review. Ann Intern Med. 2014 Apr 15;160(8):542- 9. doi: 10.7326/M13-1982. Review. 546. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j. joca.2014.01.003. Epub 2014 Jan 24.

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189 642. Rodday AM, Parsons SK, Correll CU, Robb AS, Zima BT, Saunders TS, Leslie LK. Child and adolescent psychiatrists' attitudes and practices prescribing second generation antipsychotics. J Child Adolesc Psychopharmacol. 2014 Mar; 24(2):90-3. PMID: 24679174; PMCID:PMC3967387. 643. Rogers WH, Thornton K, von Glahn T. Blending group and practice site scores to increase the reliability of physician quality information. Health Serv Res. 2014 Feb;49(1):113-26. Epub 2013 Jul 5. PubMed PMID: 23829352. 644. Rubin CL, Allukian N, Wang X, Ghosh S, Huang CC, Wang J, Brugge D, Wong JB, Mark S, Dong S, Koch-Weser S, Parsons SK, Leslie LK, Freund KM. "We make the path by walking it": building an academic community » » PUBLICATIONS partnership with Boston Chinatown. Prog Community Health Partnersh. 2014 Autumn;8(3):353-63. PubMed PMID: 25435562. 645. Sakai C, Mackie TI, Shetgiri R, Franzen S, Partap A, Flores G, Leslie LK. Mental health beliefs and barriers to accessing mental health services in youth aging out of foster care. Acad Pediatr. 2014 Nov-Dec;14(6):565-73. Epub 2014 Oct 30. PubMed PMID: 25439155. 646. Schimpf MO, Rahn DD, Wheeler TL, Patel M, White AB, Orejuela FJ, El-Nashar SA, Margulies RU, Gleason JL, Aschkenazi SO, Mamik MM, Ward RM, Balk EM, Sung VW; Society of Gynecologic Surgeons Systematic Review Group. Sling surgery for stress urinary incontinence in women: a systematic review and metaanalysis. Am J Obstet Gynecol. 2014 Jul;211(1):71.e1-71.e27. Epub 2014 Jan 30. Review. PubMed PMID: 24487005. 647. Selker HP, Udelson JE, Massaro JM, Ruthazer R, D'Agostino RB, Griffith JL, Sheehan PR, Desvigne-Nickens P, Rosenberg Y, Tian X, Vickery EM, Atkins JM, Aufderheide TP, Sayah AJ, Pirrallo RG, Levy MK, Richards ME, Braude DA, Doyle DD, Frascone RJ, Kosiak DJ, Leaming JM, Van Gelder CM, Walter GP, Wayne MA, Woolard RH, Beshansky JR. One-Year Outcomes of Out-of-Hospital Administration of Intravenous Glucose, Insulin, and Potassium (GIK) in Patients With Suspected Acute Coronary Syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care] Trial). Am J Cardiol. 2014 May 15;113(10):1599-605. Epub 2014 Mar 1. PMID: 24792735; PMCID: PMC4043184 648. Selker HP, Oye KA, Eichler HG, Stockbridge NL, Mehta CR, Kaitin KI, McElwee NE, Honig PK, Erban JK, D'Agostino RB. A Proposal for Integrated Efficacy-to-Effectiveness (E2E) Clinical Trials. Clin Pharmacol Ther. 2014 Feb;95(2):147-53. Epub 2013 Sep 23. PMID: 24060819; PMCID: PMC3904553. 649. Selker HP, Kravitz RL, Gallagher TH. The National Physician Payment Commission Recommendation to Eliminate Fee-for-Service Payment: Balancing Risk, Benefit, and Efficiency in Bundling Payment for Care. J Gen Intern Med. 2014 May;29(5):698-9. Epub 2014 Feb 27. PMID: 24573713; PMCID: PMC4000325. 650. Shaffi K, Uhlig K, Perrone RD, Ruthazer R, Rule A, Lieske JC, Navis G, Poggio ED, Inker LA, Levey AS. Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients. Am J Kidney Dis. 2014 Jun;63(6):1007-18. Epub 2014 Apr 2. PubMed PMID: 24703720; PubMed Central PMCID: PMC4113340. 651. Shenoy ES, Noubary F, Kim J, Rosenberg ES, Cotter JA, Lee H, Walensky RP, Hooper DC. Concordance of PCR and culture from nasal swabs for MRSA in setting of concurrent anti-staphylococcal antibiotics. J Clin Microbiol. 2014 Apr;52(4):1235-7. Epub 2014 Jan 22. PMID: 24452168; PMCID: PMC3993487. 652. Shenoy ES, Paras ML, Noubary F, Walensky RP, Hooper DC. Natural history of colonization with methicillin- resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review. BMC Infect Dis. 2014 Mar 31;14:177. Review. PubMed PMID: 24678646; PubMed Central PMCID: PMC4230428. 653. Silberman EK, Summergrad P, Price LL. Parameters of Training, Academic Involvement, and Practice Setting Predictive of Retention in Combined Medical-Psychiatric Practice. Academic Psychiatry. Epub 2014 Mar 25. PMID: 24664599

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 654. Sorita A, Ahmed A, Starr SR, Thompson KM, Reed DA, Dabrh AM, Prokop L, Kent DM, Shah ND, Murad MH, Ting HH. Off-hour presentation and outcomes in patients with acute ischemic stroke: A systematic reviewand meta-analysis. Eur J Intern Med. 2014 Apr;25(4):394-400. Epub 2014 Apr 12. PMID: 24721584. 655. Sullivan AL, Beshansky JR, Ruthazer R, Murman DH, Mader TJ, Selker HP. Factors associated with longer time to treatment for patients with suspected acutecoronary syndromes: a cohort study. Circ Cardiovasc Qual Outcomes. 2014 Jan 1; 7(1):86-94. Epub 2014 Jan 14. PMID: 24425697; PMCID: PMC3985420. 656. Terrin N, Rodday AM, Parsons SK. Joint Models for Predicting Transplant-Related Mortality from Quality of Life Data. Qual Life Res 2015; 24:31-39. doi: 10.1007/s11136-013-0550-2 [Epub ahead of print]. PMID: 24129669, » » PMCID: PMC3989470. PUBLICATIONS 657. Thaler DE, Ruthazer R, Weimar C, Mas JL, Serena J, Di Angelantonio E, Papetti F, Homma S, Mattle HP, Nedeltchev K, Mono ML, Jaigobin C, Michel P, Elkind MS, Di Tullio MR, Lutz JS, Griffith J, Kent DM. Recurrent stroke predictors differ in medically treated patients with pathogenic vs. other PFOs. Neurology. 2014 Jul 15;83(3):221-6. Epub 2014 Jun 13. PubMed PMID: 24928123; PubMed Central PMCID: PMC4117365. 658. Thaler DE, Ruthazer R, Weimar C, Serena J, Mattle HP, Nedeltchev K, Mono ML, Di Angelantonio E, Elkind MS, Di Tullio MR, Homma S, Michel P, Meier B, Furlan AJ, Lutz JS, Kent DM. Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke. Neurology. Epub 2014 Oct 22. PMID: 25339209. 659. Tickle-Degnen L, Saint-Hilaire M, Thomas CA, Habermann B, Martinez LS, Terrin N, Noubary F, Naumova EN. Emergence and evolution of social self-management of Parkinson's disease: study protocol for a 3-year prospective cohort study. BMC Neurol. 2014 May 2;14(1):95. PMID: 24885181; PMCID: PMC4016672. 660. Traa MX, Barboza L, Doron S, Snydman DR, Noubary F, Nasraway SA Jr. Horizontal Infection Control Strategy Decreases Methicillin-Resistant Staphylococcus aureus Infection and Eliminates Bacteremia in a Surgical ICU Without Active Surveillance. Crit Care Med. Epub 2014 Jun 27. PMID: 24979485. 661. Trikalinos T. A., Hoaglin D. C., Small K. M., Terrin N. and Schmid C. H. (2014), Methods for the joint meta- analysis of multiple tests, Research Synthesis Methods, 5, pages 294–312. 662. Uhlig K, Leff B, Kent DM, Dy S, Brunnhuber K, Burgers JS, Greenfield S , Guyatt G , High K, Leipzig R , Mulrow C, Schmader K, Schunemann H, Walter LC, Woodcock J, Boyd CM. A framework for crafting clinical practice guidelines those are relevant to the care and management of people with multimorbidity J Gen Intern Med 2014 Apr;29(4):670-679. 663. Wachman EM, Hayes MJ, Lester BM, Terrin N, Brown MS, Nielsen DA, Davis JM. Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. J Pediatr. 2014 Sep;165(3):472-8. Epub 2014 Jul 1. PubMed PMID: 24996986; PubMed Central PMCID: PMC4145036. 664. Wang C, Iversen MD, McAlindon T, Harvey WF, Wong JB, Fielding RA, Driban JB, Price LL, Rones R, Gamache T, Schmid CH. Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial. BMC Complement Altern Med. 2014 Sep 8;14:333. PubMed PMID: 25199526; PubMed Central PMCID: PMC4171546. 665. Weiner DE, Tighiouart H, Ladik V, Meyer KB, Zager PG, Johnson DS. Oral intradialytic nutritional supplement use and mortality in hemodialysis patients. Am J Kidney Dis. 2014 Feb;63(2):276-85. Epub 2013 Oct 3. PubMed PMID: 24094606. 666. Weiss CO, Varadhan R, Puhan MA, Vickers A, Bandeen-Roche K, Boyd CM, Kent DM. Multimorbidity and evidence generation. J Gen Intern Med. 2014 Apr;29(4):653-60. Epub 2014 Jan 18. Review. PubMed PMID: 24442333; PubMed Central PMCID: PMC3965759.

191 667. Welch LC, Litman HJ, Borba CP, Vincenzi B, Henderson DC. Does a Physician's Attitude toward a Patient with Mental Illness Affect Clinical Management of Diabetes? Results from a Mixed-Method Study. Health Serv Res. 2014 Dec 9. [Epub ahead of print] PubMed PMID: 25487069. 668. Wendelburg KM, O'Toole TE, McCobb E, Price LL, Lyons JA, Berg J. Risk factors for perioperative death in dogs undergoing splenectomy for splenic masses: 539 cases (2001-2012). J Am Vet Med Assoc. 2014 Dec 15;245(12):1382-90. PMID: 25459483 . 669. Wessler B, Thaler DE, Ruthazer R, Weimar C, Di Tullio MR, Elkind MS, Homma S, Lutz JS, Mas JL, Mattle HP, Meier B, Nedeltchev K, Papetti F, Di Angelantonio E, Reisman M, Serena J, Kent DM. Transesophageal » » PUBLICATIONS Echocardiography in Cryptogenic Stroke and PFO: The Analysis of Putative High Risk Features from the Risk of Paradoxical Embolism (RoPE) Database. Circ Cardiovasc Imaging. 7(1):125-31, 2014. PMID: 24214884; PMCID: PMC3934652. 670. Wilkinson J, Lauer E, Greenwood NW, Freund KM, Rosen AK. Evaluating representativeness and cancer screening outcomes in a state department of developmental services database. Intellect Dev Disabil. 2014 Apr;52(2):136-46. PubMed PMID: 24725112. 671. Wilson IB, Fowler FJ Jr, Cosenza CA, Michaud J, Bentkover J, Rana A, Kogelman L, Rogers WH. Cognitive and field testing of a new set of medication adherence self-report items for HIV care. AIDS Behav. 2014 Dec;18(12):2349-58. PubMed PMID: 24077970; PubMed Central PMCID: PMC4000749. 672. Wuerz TH, Kent DM, Malchau H, Rubash HE. A nomogram to predict major complications after hip and knee arthroplasty. J Arthroplasty. 2014 Jul;29(7):1457-62. Epub 2014 May 1. PubMed PMID: 24793891. 673. Yeh M, Aarons GA, Ho J, Leslie LK, McCabe K, & Hough RL. Parental etiological explanations and longitudinal medication use for youths with Attention Deficit Hyperactivity Disorder. Administration and Policy in Mental Health. 2014: 41(3): 401-409. PMID: 23504264 674. Zalesak M, Greenbaum JS, Cohen JT, Kokkotos F, Lustig A, Neumann PJ, Pritchard D, Stewart J, Dubois RW. The value of specialty pharmaceuticals - a systematic review. Am J Manag Care. 2014 Jun;20(6):461-72. PMID: 25180434. 675. Zhang FF, Driban JB, Lo GH, Price LL, Booth S, Eaton CB, Lu B, Nevitt M, Jackson B, Garganta C, Hochberg MC, Kwoh K, McAlindon TE. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014 Dec;144(12):2002-8. Epub 2014 Oct 1. PubMed PMID: 25411034; PubMed Central PMCID: PMC4230211. 676. Zhang M, Driban JB, Price LL, Harper D, Lo GH, Miller E, Ward RJ, McAlindon TE. Development of a rapid knee cartilage damage quantification method using magnetic resonance images. BMC Musculoskelet Disord. 2014 Aug 6;15:264. PubMed PMID: 25098589; PubMed Central PMCID: PMC4126278. 677. Zhang FF, Roberts SB, Parsons SK, Must A, Kelly MJ, Wong WW, Saltzman E. Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. J Pediatr Hematol Oncol. Epub 2014 Sep 5. PMID: 25197775 678. Zhang FF, Rodday AM, Kelly MJ, Must A, Macpherson C, Roberts SB, Saltzman E, Parsons SK. Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer. 2014 Jul;61(7):1263-9. Epub 2014 Jan 30. PMID: 24482072. 679. Zhang FF, Kelly MJ, Saltzman E, Must A, Roberts SB, Parsons SK. Obesity in Pediatric ALL Survivors: A Meta- Analysis. Pediatrics. 2014 Mar;133(3):e704-15. Epub 2014 Feb 17. PMID: 24534408; PMCID: PMC3934345.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 680. Zintzaras E, Miligkos M, Ziakas P, Balk EM, Mademtzoglou D, Doxani C, Mprotsis T, Gowri R, Xanthopoulou P, Mpoulimari I, Kokkali C, Dimoulou G, Rodopolou P, Stefanidis I, Kent DM, Hadjigeorgiou GM. Assessment of the Relative Effectiveness and Tolerability of Treatments of Type 2 Diabetes Mellitus: A Network Meta-analysis. Clin Ther. 2014 Aug 7. pii: S0149-2918(14)00430-5. doi:10.1016/j.clinthera.2014.06.035. [Epub ahead of print] Review. PubMed PMID: 25109773. 681. Zoher G, Benzel EC, Heary RF, Riew KD, Albert TJ, Butler WE, Barker II FG, Heller JG, McCormick PC, Whitmore RG, Freund KM, Schwartz JS. Cervical Spondylotic Myelopathy Surgical (CSM-S) Trial: Study Design and Rationale. Neurosurgery 2014 Jul. PMID: 24991714. » » Molecular Cardiology Research Institute PUBLICATIONS 682. Kiernan MS, French AL, DeNofrio D, Parmar YJ, Pham DT, Kapur NK, Pandian NG, Patel AR. Preoperative Three Dimensional Echocardiography to Assess Risk of Right Ventricular Failure Following Left Ventricular Assist Device Surgery. J Card Fail. 2014 Dec 20. [Epub ahead of print]. Pubmed Abstract 683. Jumean M, Pham DT, Kapur NK. Percutaneous Bi-atrial extracorporeal membrane oxygenation for acute circulatory support in advanced heart failure. Catheter Cardiovasc Interv. 2014 Dec 22. [Epub ahead of print]. Pubmed Abstract 684. Kapur NK, Paruchuri V, Thinh D, Reyelt L, Murphy B, Beale C, Bogins C, Wiener D, Nilson J, Esposito M, Perkins S, Perides G, Karas RH. Hemodynamic Effects of Left Atrial or Left Ventricular Cannulation for Acute Circulatory Support in a Bovine Model of Left Heart Injury. ASAIO J. 2014 Dec 5. [Epub ahead of print]. Pubmed Abstract 685. Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. Development of an OP9 derived cell line as a robust model to rapidly study adipocyte differentiation. PLoS One. 2014 Nov 19;9(11):e112123. Pubmed Abstract 686. Doyle JR, Harwood BN, Krishnaji ST, Krishnamurthy VM, Lin WE, Fortin JP, Kumar K, Kopin AS. A two-step strategy to enhance activity of low potency peptides. PLoS One. 2014 Nov 12;9(11):e110502. Pubmed Abstract 687. Harwood BN, Draper I, Kopin AS. Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability. J Exp Biol. 2014 Nov 15;217(Pt 22):4091-8. Pubmed Abstract Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D. γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One. 2014 Oct 14;9(10):e109416. Pubmed Abstract 688. Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Sep 22; 34(23):4343-54. Pubmed Abstract 689. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Sep 4. pii: ATVBAHA.114.302523. Pubmed Abstract 690. Gordon FK, Vallaster CS, Westerling T, Iyer LK, Brown M, Schnitzler GR. Research Resource: Aorta- and Liver- Specific ER?-Binding Patterns and Gene Regulation by Estrogen. Mol Endocrinol. 2014 Aug;28(8):1337-51. Pubmed Abstract 691. Ellis KL, Zhou Y, Beshansky JR, Ainehsazan E, Yang Y, Selker HP, Huggins GS, Cupples LA, Peter I. Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial. Pharmacogenomics J. 2014 Aug 19. doi: 10.1038/tpj.2014.41. Pubmed Abstract 692. Draper I, Mahoney LJ, Mitsuhashi S, Pacak CA, Salomon RN, Kang PB. Silencing of Drpr Leads to Muscle and Brain Degeneration in Adult Drosophila. Am J Pathol. 2014 Aug 8. pii: S0002-9440(14)00374-5. Pubmed Abstract

193 693. Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function. Endocrinology. 2014 Jul 22:en20141270. Pubmed Abstract 694. Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014 Jul 11;3(4). Pubmed Abstract 695. Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, » » PUBLICATIONS Park HJ, Galper JB. Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice. Diabetes. 2014 Jun;63(6):2097-113. Pubmed Abstract 696. Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014 Jun 2;124(6):2464-71. Pubmed Abstract 697. Koenig JB, Jaffe IZ. Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications. Curr Hypertens Rep. 2014 May;16(5):427. Pubmed Abstract 698. Jaffe IZ, Jaisser F. Endothelial cell mineralocorticoid receptors: turning cardiovascular risk factors into cardiovascular dysfunction. Hypertension. 2014 May;63(5):915-7. Pubmed Abstract 699. Doyle JR, Krishnaji ST, Zhu G, Xu ZZ, Heller D, Ji RR, Levy BD, Kumar K, Kopin AS. Development of a membrane- anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Pubmed Abstract 700. Bene NC, Alcaide P, Wortis HH, Jaffe IZ. Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease. Steroids. 2014 Apr 21. Pubmed Abstract 701. Chen CW, Jaffe IZ, Karumanchi SA. Pre-eclampsia and cardiovascular disease. Cardiovasc Res. 2014 Mar 15;101(4):579-86. Pubmed Abstract 702. Kapur NK, Paruchuri V. Interventions for failing vessels, valves, and now . ventricles: the parachute device. Catheter Cardiovasc Interv. 2014 Mar 1;83(4):631-2. Pubmed Abstract 703. Hayden RS, Fortin JP, Harwood B, Subramanian B, Quinn KP, Georgakoudi I, Kopin AS, Kaplan DL. Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts. Adv Funct Mater. 2014 Jan 29;24(4):472-479. Pubmed Abstract 704. Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, ... Huggins GS, ... Taylor KC. Gene- centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014 Jan 6. [Epub ahead of print]. Pubmed Abstract 705. Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak JF, Karas RH, Wanke CA. Lipoprotein-Associated Phospholipase A2, a Novel Cardiovascular Inflammatory Marker, in HIV-Infected Patients. Clin Infect Dis. 2014 Jan 2. [Epub ahead of print]. Pubmed Abstract 706. Rock ML, Karas AZ, Rodriguez KB, Gallo MS, Pritchett-Corning K, Karas RH, Aronovitz M, Gaskill BN. The time- to-integrate-to-nest test as an indicator of wellbeing in laboratory mice. J Am Assoc Lab Anim Sci. 2014 Jan;53(1):24-8. Pubmed Abstract

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 Molecular Oncology Research Institute 707. Arendt L, Keller P, Skibinski A, Goncalves K, Naber S, Buchsbaum RJ, Gilmore H, Come S, Kuperwasser C. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast cancer research: BCR 2014;16:453. 708. Jun HJ, Roy J, Smith TB, Wood LB, Lane k, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology 2014;155:3661-73. 709. Chiu B, Coburn J, Pilichowska M, Holcroft C, Seib FP, Charest A, Kaplan DL. Surgery combined with controlled- »

release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model. British » PUBLICATIONS journal of cancer 2014;111:708-15. 710. Jun HJ, Bronson RT, Charest A. Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma. Stem cells 2014;32:338-48. 711. Foley, C.J.,Fanjul-Fernandez, R., Bohm, A., Nguyen, N., Agarwal, A., Austin, K., Koukos, G., Covic, L., Lopez-Otin, C., Kuliopulos, A. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. (2014) Oncogene. 33(17):2264-72. 712. Rajabi HN, Takahashi C, Ewen ME. Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. The Journal of biological chemistry 2014;289:23417-27. 713. Liu Q, Boudot A, Ni J, Hennessey T, Beauparlant S, Rajabi H, Zahnow C, Ewen ME. Cyclin D1 and C/EBPbeta LAP1 operate in a common pathway to promote mammary epithelial cell differentiation. Molecular and cellular biology 2014;34:3168-79. 714. Shah U, Kritharis A, Evens AM. Paraneoplastic pyoderma gangrenosum with posttransplant lymphoproliferative disorder. Annals of hematology 2014. 715. Evens AM, Kostakoglu L. The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. Blood 2014;124:3356-64. 716. Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Clinical cancer research : an official journal of the American Association for Cancer Research 2014;20:6023-33. 717. Loughran TP, Jr., Zickl L, Olson TL, Wang V, Zhang D, Rajala HL, Hasanali Z, Bennett JM, Lazarus HM, Litzow MR, Evens AM, Mustjoki S, Tallman MS. Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998). Leukemia 2014. 718. Abramson JS, Feldman T, Kroll-Desrosiers AR, Muffly LS, Winer E, Flowers CR, Lansigan F, Nabhan C, Nastoupil LJ, Nath R, Goy A, Castillo JJ, Jagadeesh D, Woda B, Rosen ST, Smith SM, Evens AM. Peripheral T-cell lymphomas in a large US multicenter cohort: prognostication in the modern era including impact of frontline therapy. Annals of Oncology: official journal of the European Society for Medical Oncology/ESMO 2014;25:2211-7. 719. Kostakoglu L, Evens AM. FDG-PET imaging for Hodgkin lymphoma: current use and future applications. Clinical advances in hematology & oncology: H&O 2014;12:20-35. 720. Gandhi MD, Evens AM, Fenske TS, et al. Pancreatitis in patients treated with brentuximab vedotin: a previously unrecognized serious adverse event. Blood 2014;123:2895-7.

195 721. Evens AM, Smith MR, Lossos IS, Helenowski I, Millenson M, Winter JN, Rosen ST, Gordon LI. Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma: a multicentre phase II study. British journal of haematology 2014;166:514-20. 722. DeVita MD, Evens AM, Rosen ST, Greenberger PA, Petrich AM. Multiple successful desensitizations to brentuximab vedotin: a case report and literature review. Journal of the National Comprehensive Cancer Network: JNCCN 2014;12:465-71. 723. Nabhan C, Aschebrook-Kilfoy B, Chiu BC, Kruczek K, Smith SM, Evens AM. The impact of race, age, and sex in follicular lymphoma: A comprehensive SEER analysis across consecutive treatment eras. American journal of » » PUBLICATIONS hematology 2014;89:633-8. 724. Gentzler RD, Evens AM, Rademaker AW, Weitner BB, Mittal BB, Dillehay GL, Petrich AM, Altman JK, Frankfurt O, Variakojis D, Singhal S, Mehta J, Williams S, Kaminer L, Gordon LI, Winter JN. F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma. British Journal of Haematology 2014;165:793-800. 725. Nabhan C, Aschebrook-Kilfoy B, Chiu BC, Smith SM, Shanafelt TD, Evens AM, Kay NE. The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia: a comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era. Leukemia & lymphoma 2014; 55:2778-84. 726. Reddy NM, Evens AM. Chemotherapeutic advancements in peripheral T-cell lymphoma. Seminars in hematology 2014;51:17-24. 727. Hosein PJ, Maragulia JC, Salzberg MP, Press OW, Habermann TM, Vose JM, Bast M, Advani RH, Tibshirani R, Evens AM, Islam N, Leonard JP, Martin P, Zelenetz AD, Lossos IS. A multicentre study of primary breast diffuse large B-cell lymphoma in the rituximab era. British journal of haematology 2014;165:358-63. 728. Shin J, Phelan PJ, Chhum P, Bashkenova N, Yim S, Parker R, Gagnon D, Gjoerup O, Archambault J, Bullock PA. Analysis of JC virus DNA replication using a quantitative and high-throughput assay. Virology 2014;468-470:113-25. 729. Forero A, Giacobbi NS, McCormick KD, Gjoerup OV, Bakkenist CJ, Pipas JM, Sarkar SN. Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase. Journal of immunology 2014;192:5933-42. 730. Hinds PW. A little pRB can lead to big problems. Cancer discovery 2014;4:764-5. 731. Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer research 2014;74:3935-46. 732. Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop. The Journal of biological chemistry 2014;289:12520-34. 733. Kohrt D, Crary J, Zimmer M, Patrick A, Ford H, Hinds PW, Grossel M. CDK6 binds and promotes the degradation of the EYA2 protein. Cell cycle 2014;13:62-71. 734. Del Giudice R, Monti DM, Sarcinelli C, Arciello A, Piccoli R, Hu GF. Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin. Cell death & disease 2014;5:e1097. 735. Sheng J, Luo C, Jiang Y, Hinds PW, Xu Z, Hu GF. Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop. The Journal of biological chemistry 2014;289:12520-34. 736. Sheng J, Yu W, Gao X, Xu Z, Hu GF. Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter. J Cell Physiol. 2014; 229:521-529.

TUFTS MEDICAL CENTER DEPARTMENT OF MEDICINE — ANNUAL REPORT 2014 737. Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M. Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress. Mol Cell Biol. 2014;34:2450-2463. 738. Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Hu GF, Sasaki A. Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation. Anticancer Res. 2014; 34:2113-2121. 739. Foley CJ, Kuliopulos A. Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP function. Journal of cellular physiology 2014;229:1875-80. » » 740. Foley CJ, Fanjul-Fernández M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos PUBLICATIONS G, Covic L, López-Otín C, Kuliopulos A. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogene 2014;33:2264-72. 741. Zhang, P., Covic, L. & Kuliopulos, A. (2014) Antiplatelet Therapy and Cardiovascular Disease. 29-44. Ed. Ron Waksman. Wiley-Blackwell. Ch. 5. Platelet receptors and drug targets: PAR-1, collagen, vWF, thromboxane, and other novel targets. 742. Arendt LM, St. Laurent J, Wronski A, Caballero S, Lyle SR, Naber SP, Kuperwasser C. Human breast progenitor cell numbers are regulated by WNT and TBX3. PloS one 2014;9:e111442. 743. Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, Kuperwasser C. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast cancer research : BCR 2014;16:453. 744. Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C. Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation. Stem cell reports 2014;2:633-47. 745. Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer research 2014;74:3935-46. 746. Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, LaBaer J, Kuperwasser C. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell reports 2014;6:1059-72. 747. McCready J, Arendt LM, Glover E, Iyer V, Briendel JL, Lyle SR, Naber SP, Jay DG, Kuperwasser C. Pregnancy- associated breast cancers are driven by differences in adipose stromal cells present during lactation. Breast cancer research : BCR 2014;16:R2. 748. Mathew P. The bifunctional role of steroid hormones: implications for therapy in prostate cancer. Oncology (Williston Park) 2014;28:397-404. 749. Mathew P. The hemostatic system as a therapeutic target in urothelial carcinoma. Oncology (Williston Park) 2014;28. 750. Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer research 2014;74:3935-46. 751. Kanellis DC, Bursac S, Tsichlis PN, Volarevic S, Eliopoulos AG. Physical and functional interaction of the TPL2 kinase with nucleophosmin. Oncogene 2014.

197 752. Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer research 2014;74:3935-46. 753. Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS pathogens 2014;10:e1004136. 754. Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, » » PUBLICATIONS O’Garra A, Prinz M, Kollias G, Ley SC. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. Journal of immunology 2014;192:3518-29. 755. Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz OH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer letters 2014;347:204-11. 756. Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner K. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Molecular and cellular biology 2014;34:1363-77. 757. Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Molecular cell 2014;53:577-90. 758. Corum DG, Tsichlis PN, Muise-Helmericks RC. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014;28:395-407. 759. O’Leary E, Larson E, Lin AY, Reardon S, Lee P, Russell M, Melnitchouk N, Hart S, Ghassemi K, Hecht JR, Wainberg Z, Yoo J. A Multi-Disciplinary Cancer Program Enhances Hereditary Colorectal Cancer Detection. Am J Dig Dis 2014; 1(1):62-66. 760. Larson ES, Khalil HA, Lin AY, Russell M, Ardehali A, Ross D, Yoo J. Diverticulitis Occurs Early After Lung Transplantation, J Surg Res 2014; 190(2): 667-71.

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