CONTENTS • JANUARY/FEBRUARY 2018 • VOLUME 9, NO. 1

FEATURED IMAGE Featured image: SEM image of enteroaggregative E. coli (EAEC) exhibiting their characteristic stacked brick formation on enteroids. False colors show bacteria (pink), enteroid monolayers (green), and mucus (purple). We thank Reid L. Wilson (Rice University) and Jim P. Barrish (TX Children’s Hospital) for their kind help. [See related article: Rajan et al., mBio 9(1):e02419-17, 2018.] © 2018 Rajan et al. CC-BY 4.0.

EDITORIALS Acknowledgment of Reviewers e02302-17 Arturo Casadevall Elegant Science e00043-18 Arturo Casadevall, Ferric C. Fang

PERSPECTIVE The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall e02267-17 Maarten G. K. Ghequire, Susan K. Buchanan, René De Mot

COMMENTARIES In Nature, There Is Only Diversity e02149-17 Michael R. McLaren, Benjamin J. Callahan Timing Is Everything e02140-17 Luis M. Schang Microbial Unmasking of Plant Glycosides e02433-17 Kristen A. Biernat, Bo Li, Matthew R. Redinbo

OPINION/HYPOTHESIS Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source e01947-17 Jianbo Zhang, Shana Sturla, Christophe Lacroix, Clarissa Schwab

MINIREVIEWS The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in e02122-17 Response to Environmental and Host Cues Nicole J. De Nisco, Giomar Rivera-Cancel, Kim Orth Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus? e01923-17 Diana Gutiérrez, Lucía Fernández, Ana Rodríguez, Pilar García Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed e01932-17 Therapies: Current Progress, Outlook, and Challenges Chih-Yuan Chiang, Ijeoma Uzoma, Richard T. Moore, Merle Gilbert, Allen J. Duplantier, Rekha G. Panchal Ethanolamine Utilization in Bacteria e00066-18 Karan Gautam Kaval, Danielle A. Garsin CONTENTS • JANUARY/FEBRUARY 2018 • VOLUME 9, NO. 1

OBSERVATIONS Cyclic AMP Regulates Bacterial Persistence through Repression of the Oxidative e02144-17 Stress Response and SOS-Dependent DNA Repair in Uropathogenic Escherichia coli Roberto C. Molina-Quiroz, Cecilia Silva-Valenzuela, Jennifer Brewster, Eduardo Castro-Nallar, Stuart B. Levy, Andrew Camilli Glycan-Glycan Interaction Determines Shigella Tropism toward Human e02309-17 T Lymphocytes Ilia Belotserkovsky, Katja Brunner, Laurie Pinaud, Alexander Rouvinski, Mariano Dellarole, Bruno Baron, Gyanendra Dubey, Fatoumata Samassa, Claude Parsot, Philippe Sansonetti, Armelle Phalipon Structural Basis for DNA Recognition by the Two-Component Response e01993-17 Regulator RcsB Ekaterina V. Filippova, Bozena Zemaitaitis, Theint Aung, Alan J. Wolfe, Wayne F. Anderson

RESEARCH ARTICLES Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in e01818-17 Less Acidic Endosomal Compartments Christine E. Hulseberg, Lucie Fénéant, Katarzyna M. Szyman´ska, Judith M. White Range Expansion and the Origin of USA300 North American Epidemic e02016-17 Methicillin-Resistant Staphylococcus aureus Lavanya Challagundla, Xiao Luo, Isabella A. Tickler, Xavier Didelot, David C. Coleman, Anna C. Shore, Geoffrey W. Coombs, Daniel O. Sordelli, Eric L. Brown, Robert Skov, Anders Rhod Larsen, Jinnethe Reyes, Iraida E. Robledo, Guillermo J. Vazquez, Raul Rivera, Paul D. Fey, Kurt Stevenson, Shu-Hua Wang, Barry N. Kreiswirth, Jose R. Mediavilla, Cesar A. Arias, Paul J. Planet, Rathel L. Nolan, Fred C. Tenover, Richard V. Goering, D. Ashley Robinson ATG8 Is Essential Specifically for an Autophagy-Independent Function in e02021-17 Apicoplast Biogenesis in Blood-Stage Malaria Parasites Marta Walczak, Suresh M. Ganesan, Jacquin C. Niles, Ellen Yeh Role of Heat Shock Proteases in Quorum-Sensing-Mediated Regulation of Biofilm e02086-17 Formation by Vibrio Species Kyung-Jo Lee, You-Chul Jung, Soon-Jung Park, Kyu-Ho Lee O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian e02121-17 Body Temperatures Andrew L. Garfoot, Kristie D. Goughenour, Marcel Wüthrich, Murugesan V. S. Rajaram, Larry S. Schlesinger, Bruce S. Klein, Chad A. Rappleye Spatiotemporally Heterogeneous Population Dynamics of Gut Bacteria Inferred e01453-17 from Fecal Time Series Data Hidetoshi Inamine, Stephen P. Ellner, Peter D. Newell, Yuan Luo, Nicolas Buchon, Angela E. Douglas Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment e01678-17 and Replication and Respond to Infection by Producing Immunomodulatory Chemokines Stephanie E. Ander, Elizabeth N. Rudzki, Nitin Arora, Yoel Sadovsky, Carolyn B. Coyne, Jon P. Boyle

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Exploration of the Germline Genome of the Ciliate Chilodonella uncinata through e01836-17 Single-Cell Omics (Transcriptomics and Genomics) Xyrus X. Maurer-Alcalá, Rob Knight, Laura A. Katz Streptococcus pneumoniae Modulates Staphylococcus aureus Biofilm Dispersion e02089-17 and the Transition from Colonization to Invasive Disease Ryan M. Reddinger, Nicole R. Luke-Marshall, Shauna L. Sauberan, Anders P. Hakansson, Anthony A. Campagnari The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus e01828-17 neoformans Jorge Masso-Silva, Vanessa Espinosa, Tong-Bao Liu, Yina Wang, Chaoyang Xue, Amariliz Rivera Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel e01761-17 Clostridial Conjugation Locus Callum J. Vidor, Thomas D. Watts, Vicki Adams, Dieter Bulach, Edward Couchman, Julian I. Rood, Neil F. Fairweather, Milena Awad, Dena Lyras Secondary Metabolism and Interspecific Competition Affect Accumulation of e01845-17 Spontaneous Mutants in the GacS-GacA Regulatory System in Pseudomonas protegens Qing Yan, Lucas D. Lopes, Brenda T. Shaffer, Teresa A. Kidarsa, Oliver Vining, Benjamin Philmus, Chunxu Song, Virginia O. Stockwell, Jos M. Raaijmakers, Kerry L. McPhail, Fernando D. Andreote, Jeff H. Chang, Joyce E. Loper Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced e02091-17 Susceptibility to Death during the 2009 H1N1 Pandemic Alain Gagnon, Enrique Acosta, Stacey Hallman, Robert Bourbeau, Lisa Y. Dillon, Nadine Ouellette, David J. D. Earn, D. Ann Herring, Kris Inwood, Joaquin Madrenas, Matthew S. Miller Simultaneous Binding of Multiple EF-Tu Copies to Translating Ribosomes in Live e02143-17 Escherichia coli Mainak Mustafi, James C. Weisshaar Immune Protection against Lethal Fungal-Bacterial Intra-Abdominal Infections e01472-17 Elizabeth A. Lilly, Melanie Ikeh, Evelyn E. Nash, Paul L. Fidel, Jr., Mairi C. Noverr Molecular Insights into Function and Competitive Inhibition of Pseudomonas e02158-17 aeruginosa Multiple Virulence Factor Regulator Tomoe Kitao, Francois Lepine, Seda Babloudi, Frederick Walte, Stefan Steinbacher, Klaus Maskos, Michael Blaesse, Michele Negri, Michael Pucci, Bob Zahler, Antonio Felici, Laurence G. Rahme Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential e02217-17 Role in Kaposi’s Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis Hye-Ra Lee, Fan Li, Un Yung Choi, Hye Ryun Yu, Grace M. Aldrovandi, Pinghui Feng, Shou-Jiang Gao, Young-Kwon Hong, Jae U. Jung Mucosal Infections and Invasive Potential of Nonencapsulated Streptococcus e02097-17 pneumoniae Are Enhanced by Oligopeptide Binding Proteins AliC and AliD Jessica L. Bradshaw, Haley R. Pipkins, Lance E. Keller, James K. Pendarvis, Larry S. McDaniel

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Contrasting Function of Structured N-Terminal and Unstructured C-Terminal e01712-17 Segments of Mycobacterium tuberculosis PPE37 Protein Javeed Ahmad, Aisha Farhana, Rita Pancsa, Simran Kaur Arora, Alagiri Srinivasan, Anil Kumar Tyagi, Madan Mohan Babu, Nasreen Zafar Ehtesham, Seyed Ehtesham Hasnain Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome e01663-17 Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity Kumaraguruparan Ramasamy, Sowmya Balasubramanian, Krishnan Manickam, Lavanya Pandranki, Alexander B. Taylor, P. John Hart, Joel B. Baseman, T. R. Kannan Stress-Induced Reorganization of the Mycobacterial Membrane Domain e01823-17 Jennifer M. Hayashi, Kirill Richardson, Emily S. Melzer, Steven J. Sandler, Bree B. Aldridge, M. Sloan Siegrist, Yasu S. Morita Genomic Analyses Reveal the Common Occurrence and Complexity of e01888-17 Plasmodium vivax Relapses in Cambodia Jean Popovici, Lindsey R. Friedrich, Saorin Kim, Sophalai Bin, Vorleak Run, Dysoley Lek, Matthew V. Cannon, Didier Menard, David Serre Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and e02178-17 Fungal Virulence Jonathan P. Richardson, Selene Mogavero, David L. Moyes, Mariana Blagojevic, Thomas Krüger, Akash H. Verma, Bianca M. Coleman, Jacinto De La Cruz Diaz, Daniela Schulz, Nicole O. Ponde, Giulia Carrano, Olaf Kniemeyer, Duncan Wilson, Oliver Bader, Simona I. Enoiu, Jemima Ho, Nessim Kichik, Sarah L. Gaffen, Bernhard Hube, Julian R. Naglik Adaptive Evolution of RH5 in Ape Plasmodium species of the Laverania e02237-17 Subgenus Lindsey J. Plenderleith, Weimin Liu, Oscar A. MacLean, Yingying Li, Dorothy E. Loy, Sesh A. Sundararaman, Frederic Bibollet-Ruche, Gerald H. Learn, Beatrice H. Hahn, Paul M. Sharp Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of e02284-17 Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus Jae-Keun Park, Alison Han, Lindsay Czajkowski, Susan Reed, Rani Athota, Tyler Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, Jeffery K. Taubenberger, Matthew J. Memoli The Ancient Link between G-Protein-Coupled Receptors and C-Terminal e02119-17 Phospholipid Kinase Domains D. Johan van den Hoogen, Harold J. G. Meijer, Michael F. Seidl, Francine Govers Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis e01755-17 Sepsis and Is a Potential Target for Disease Treatment Johannes B. Herrmann, Marcel Muenstermann, Lea Strobel, Alexandra Schubert-Unkmeir, Trent M. Woodruff, Scott D. Gray-Owen, Andreas Klos, Kay O. Johswich A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion e02146-17 System in Host Xiaofeng Zhou, Doron Teper, Maxuel O. Andrade, Tong Zhang, Sixue Chen, Wen-Yuan Song, Nian Wang

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Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate e02272-17 Virulence Lamia Harper, Divya Balasubramanian, Elizabeth A. Ohneck, William E. Sause, Jessica Chapman, Bryan Mejia-Sosa, Tenzin Lhakhang, Adriana Heguy, Aristotelis Tsirigos, Beatrix Ueberheide, Jeffrey M. Boyd, Desmond S. Lun, Victor J. Torres Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and e02164-17 Restricted to Invasive Chlamydia trachomatis Biovars Michael John Patton, Chih-Yu Chen, Chunfu Yang, Stuart McCorrister, Chris Grant, Garrett Westmacott, Xin-Yong Yuan, Estela Ochoa, Robert Fariss, William M. Whitmire, John H. Carlson, Harlan D. Caldwell, Grant McClarty Conditional Protein Splicing Switch in Hyperthermophiles through an Intein- e02304-17 Extein Partnership Christopher W. Lennon, Matthew Stanger, Nilesh K. Banavali, Marlene Belfort Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates e02318-17 Pyocyanin and Pyoverdine Production Alexander S. Little, Yuta Okkotsu, Alexandria A. Reinhart, F. Heath Damron, Mariette Barbier, Brandon Barrett, Amanda G. Oglesby-Sherrouse, Joanna B. Goldberg, William L. Cody, Michael J. Schurr, Michael L. Vasil, Michael J. Schurr Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate e02294-17 Antigen in Non-M1-Serotype Group A Streptococcus Anna Henningham, Mark R. Davies, Satoshi Uchiyama, Nina M. van Sorge, Sean Lund, Kelsey T. Chen, Mark J. Walker, Jason N. Cole, Victor Nizet UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus e02319-17 neoformans Lucy X. Li, Carsten Rautengarten, Joshua L. Heazlewood, Tamara L. Doering Metagenomes Reveal Global Distribution of Bacterial Steroid Catabolism in e02345-17 Natural, Engineered, and Host Environments Johannes Holert, Erick Cardenas, Lee H. Bergstrand, Elena Zaikova, Aria S. Hahn, Steven J. Hallam, William W. Mohn Translation Stress Positively Regulates MscL-Dependent Excretion of Cytoplasmic e02118-17 Proteins Rosa Morra, Francesco Del Carratore, Howbeer Muhamadali, Luminita Gabriela Horga, Samantha Halliwell, Royston Goodacre, Rainer Breitling, Neil Dixon QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species e02262-17 Byoung Sik Kim, Song Yee Jang, Ye-ji Bang, Jungwon Hwang, Youngwon Koo, Kyung Ku Jang, Dongyeol Lim, Myung Hee Kim, Sang Ho Choi Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed e02314-17 Viruses Nicholas Rinkenberger, John W. Schoggins Adjustments to Photosystem Stoichiometry and Electron Transfer Proteins Are e02327-17 Key to the Remarkably Fast Growth of the Cyanobacterium Synechococcus elongatus UTEX 2973 Justin Ungerer, Po-Cheng Lin, Hui-Yuan Chen, Himadri B. Pakrasi

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CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral e02372-17 Latent Chromatin and Contributes to Poised Latent Infection Jennifer S. Lee, Priya Raja, Dongli Pan, Jean M. Pesola, Donald M. Coen, David M. Knipe Physiological Heterogeneity Triggers Sibling Conflict Mediated by the Type VI e01645-17 Secretion System in an Aggregative Multicellular Bacterium Vera Troselj, Anke Treuner-Lange, Lotte Søgaard-Andersen, Daniel Wall Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial e02011-17 Plasmids Conferring Carbapenem Resistance Rebecca A. Weingarten, Ryan C. Johnson, Sean Conlan, Amanda M. Ramsburg, John P. Dekker, Anna F. Lau, Pavel Khil, Robin T. Odom, Clay Deming, Morgan Park, Pamela J. Thomas, NISC Comparative Sequencing Program, David K. Henderson, Tara N. Palmore, Julia A. Segre, Karen M. Frank Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To e02287-17 Regulate Heme Biosynthesis Jacob E. Choby, Caroline M. Grunenwald, Arianna I. Celis, Svetlana Y. Gerdes, Jennifer L. DuBois, Eric P. Skaar Layered Structure and Complex Mechanochemistry Underlie Strength and e02359-17 Versatility in a Bacterial Adhesive Mercedes Hernando-Pérez, Sima Setayeshgar, Yifeng Hou, Roger Temam, Yves V. Brun, Bogdan Dragnea, Cécile Berne The Viscoelastic Properties of the Fungal Cell Wall Allow Traffic of AmBisome as e02383-17 Intact Liposome Vesicles Louise Walker, Prashant Sood, Megan D. Lenardon, Gillian Milne, Jon Olson, Gerard Jensen, Julie Wolf, Arturo Casadevall, Jill Adler-Moore, Neil A. R. Gow Prevalence of Infection-Competent Serogroup 6 Legionella pneumophila within e00016-18 Premise Plumbing in Southeast Michigan Brenda G. Byrne, Sarah McColm, Shawn P. McElmurry, Paul E. Kilgore, Joanne Sobeck, Rick Sadler, Nancy G. Love, Michele S. Swanson Expanding Primary Metabolism Helps Generate the Metabolic Robustness To e02283-17 Facilitate Antibiotic Biosynthesis in Streptomyces Jana K. Schniete, Pablo Cruz-Morales, Nelly Selem-Mojica, Lorena T. Fernández-Martínez, Iain S. Hunter, Francisco Barona-Gómez, Paul A. Hoskisson Colocalization and Disposition of Cellulosomes in Clostridium clariflavum as e00012-18 Revealed by Correlative Superresolution Imaging Lior Artzi, Tali Dadosh, Elad Milrot, Sarah Moraïs, Smadar Levin-Zaidman, Ely Morag, Edward A. Bayer Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human e02344-17 and Simian Immunodeficiency Viruses Ryan P. McNamara, Lindsey M. Costantini, T. Alix Myers, Blake Schouest, Nicholas J. Maness, Jack D. Griffith, Blossom A. Damania, Andrew G. MacLean, Dirk P. Dittmer

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Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter e02394-17 baumannii Gregory A. Knauf, Ashley L. Cunningham, Misha I. Kazi, Ian M. Riddington, Alexander A. Crofts, Vincent Cattoir, M. Stephen Trent, Bryan W. Davies The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the e02381-17 Vehicle for Transferable Colistin Resistance Erik Snesrud, Patrick McGann, Michael Chandler Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii e02027-17 Infection Tatiane S. Lima, Lanny Gov, Melissa B. Lodoen Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress e02375-17 Xiongfeng Dai, Manlu Zhu, Mya Warren, Rohan Balakrishnan, Hiroyuki Okano, James R. Williamson, Kurt Fredrick, Terence Hwa An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum e02443-17 Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH Yu Tang, Yuantai Wu, Sarah E. Herlihy, Francisco J. Brito-Aleman, Jose H. Ting, Chris Janetopoulos, Richard H. Gomer Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral e00064-18 Genomes for Rapid Repair and Amplification Kavi Mehta, Laimonis Laimins A High-Throughput Approach for Identification of Nontuberculous Mycobacteria in e02354-17 Drinking Water Reveals Relationship between Water Age and Mycobacterium avium Sarah-Jane Haig, Nadine Kotlarz, John J. LiPuma, Lutgarde Raskin Enterococcus faecalis Sex Pheromone cCF10 Enhances Conjugative Plasmid e00037-18 Transfer In Vivo Helmut Hirt, Kerryl E. Greenwood-Quaintance, Melissa J. Karau, Lisa M. Till, Purna C. Kashyap, Robin Patel, Gary M. Dunny Functional Analysis of Mating Type Genes and Transcriptome Analysis during e01939-17 Fruiting Body Development of Botrytis cinerea Sander Y. A. Rodenburg, Razak B. Terhem, Javier Veloso, Joost H. M. Stassen, Jan A. L. van Kan CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by e02406-17 Transduction Bridget N. J. Watson, Raymond H. J. Staals, Peter C. Fineran De Novo Assembly and Phasing of Dikaryotic Genomes from Two Isolates of e01650-17 Puccinia coronata f. sp. avenae, the Causal Agent of Oat Crown Rust Marisa E. Miller, Ying Zhang, Vahid Omidvar, Jana Sperschneider, Benjamin Schwessinger, Castle Raley, Jonathan M. Palmer, Diana Garnica, Narayana Upadhyaya, John Rathjen, Jennifer M. Taylor, Robert F. Park, Peter N. Dodds, Cory D. Hirsch, Shahryar F. Kianian, Melania Figueroa A Near-Complete Haplotype-Phased Genome of the Dikaryotic Wheat Stripe Rust e02275-17 Fungus Puccinia striiformis f. sp. tritici Reveals High Interhaplotype Diversity Benjamin Schwessinger, Jana Sperschneider, William S. Cuddy, Diana P. Garnica, Marisa E. Miller, Jennifer M. Taylor, Peter N. Dodds, Melania Figueroa, Robert F. Park, John P. Rathjen

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Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli e02419-17 Adherence to Human Intestinal Enteroids Anubama Rajan, Lucy Vela, Xi-Lei Zeng, Xiaomin Yu, Noah Shroyer, Sarah E. Blutt, Nina M. Poole, Lily G. Carlin, James P. Nataro, Mary K. Estes, Pablo C. Okhuysen, Anthony W. Maresso N-glycosylation of Viral E Protein Is the Determinant for Vector Midgut Invasion e00046-18 by Flaviviruses Dan Wen, Suhua Li, Fangfang Dong, Yanan Zhang, Yongfang Lin, Jumei Wang, Zhen Zou, Aihua Zheng The Essential Genome of Escherichia coli K-12 e02096-17 Emily C. A. Goodall, Ashley Robinson, Iain G. Johnston, Sara Jabbari, Keith A. Turner, Adam F. Cunningham, Peter A. Lund, Jeffrey A. Cole, Ian R. Henderson Yersinia pestis Targets the Host Endosome Recycling Pathway during the e01800-17 Biogenesis of the Yersinia-Containing Vacuole To Avoid Killing by Macrophages Michael G. Connor, Amanda R. Pulsifer, Donghoon Chung, Eric C. Rouchka, Brian K. Ceresa, Matthew B. Lawrenz Functional and Expression Analyses of the Pneumocystis MAT Genes Suggest e02201-17 Obligate Sexuality through Primary Homothallism within Host Lungs S. Richard, J. M. G. C. F. Almeida, O. H. Cissé, A. Luraschi, O. Nielsen, M. Pagni, P. M. Hauser Microbial Functional Gene Diversity Predicts Groundwater Contamination and e02435-17 Ecosystem Functioning Zhili He, Ping Zhang, Linwei Wu, Andrea M. Rocha, Qichao Tu, Zhou Shi, Bo Wu, Yujia Qin, Jianjun Wang, Qingyun Yan, Daniel Curtis, Daliang Ning, Joy D. Van Nostrand, Liyou Wu, Yunfeng Yang, Dwayne A. Elias, David B. Watson, Michael W. W. Adams, Matthew W. Fields, Eric J. Alm, Terry C. Hazen, Paul D. Adams, Adam P. Arkin, Jizhong Zhou Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi e00105-18 Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins Elizabeth J. Klemm, Sadia Shakoor, Andrew J. Page, Farah Naz Qamar, Kim Judge, Dania K. Saeed, Vanessa K. Wong, Timothy J. Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Saleem, Zahra Hasan, Gordon Dougan, Rumina Hasan Efficient and Scalable Precision Genome Editing in Staphylococcus aureus e00067-18 through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection Kelsi Penewit, Elizabeth A. Holmes, Kathyrn McLean, Mingxin Ren, Adam Waalkes, Stephen J. Salipante Gene Flow between Divergent Cereal- and Grass-Specific Lineages of the Rice e01219-17 Blast Fungus Magnaporthe oryzae Pierre Gladieux, Bradford Condon, Sebastien Ravel, Darren Soanes, Joao Leodato Nunes Maciel, Antonio Nhani, Jr., Li Chen, Ryohei Terauchi, Marc-Henri Lebrun, Didier Tharreau, Thomas Mitchell, Kerry F. Pedley, Barbara Valent, Nicholas J. Talbot, Mark Farman, Elisabeth Fournier

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Tracking Electron Uptake from a Cathode into Shewanella Cells: Implications for e02203-17 Energy Acquisition from Solid-Substrate Electron Donors Annette R. Rowe, Pournami Rajeev, Abhiney Jain, Sahand Pirbadian, Akihiro Okamoto, Jeffrey A. Gralnick, Mohamed Y. El-Naggar, Kenneth H. Nealson Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in e00084-18 Saccharomyces cerevisiae Dustin C. Ernst, Diana M. Downs Widespread Distribution and Functional Specificity of the Copper Importer CcoA: e00065-18 Distinct Cu Uptake Routes for Bacterial Cytochrome c Oxidases Bahia Khalfaoui-Hassani, Hongjiang Wu, Crysten E. Blaby-Haas, Yang Zhang, Federica Sandri, Andreia F. Verissimo, Hans-Georg Koch, Fevzi Daldal Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific e00130-18 Organelles in Plasmodium falciparum Sabrina Absalon, Karin Blomqvist, Rachel M. Rudlaff, Travis J. DeLano, Michael P. Pollastri, Jeffrey D. Dvorin Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli e00097-18 Virulence Colin D. Robertson, Tracy H. Hazen, James B. Kaper, David A. Rasko, Anne-Marie Hansen Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing e02052-17 Sensor Kinases of the BvgS Family Elodie Lesne, Elian Dupré, Marc F. Lensink, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson Invasion of the Brain by Listeria monocytogenes Is Mediated by InlF and Host e00160-18 Cell Vimentin Pallab Ghosh, Elizabeth M. Halvorsen, Dustin A. Ammendolia, Nirit Mor-Vaknin, Mary X. D. O’Riordan, John H. Brumell, David M. Markovitz, Darren E. Higgins Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple e00008-18 Genotypes of Japanese Encephalitis Virus Estefania Fernandez, Nurgun Kose, Melissa A. Edeling, Jagat Adhikari, Gopal Sapparapu, Susana M. Lazarte, Christopher A. Nelson, Jennifer Govero, Michael L. Gross, Daved H. Fremont, James E. Crowe, Jr., Michael S. Diamond Role of the Antigen Capture Pathway in the Induction of a Neutralizing Antibody e00209-18 Response to Anthrax Protective Antigen Anita Verma, Miriam M. Ngundi, Gregory A. Price, Kazuyo Takeda, James Yu, Drusilla L. Burns Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress e00211-18 Liam F. Fitzsimmons, Lin Liu, Ju-Sim Kim, Jessica Jones-Carson, Andrés Vázquez-Torres

ERRATA Erratum for Barouch-Bentov et al., “Hepatitis C Virus Proteins Interact with the e02234-17 Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment” Rina Barouch-Bentov, Gregory Neveu, Fei Xiao, Melanie Beer, Elena Bekerman, Stanford Schor, Joseph Campbell, Jim Boonyaratanakornkit, Brett Lindenbach, Albert Lu, Yves Jacob, Shirit Einav

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Erratum for Petruzzi et al., “Capsular Polysaccharide Interferes with Biofilm e00176-18 Formation by Pasteurella multocida Serogroup A” Briana Petruzzi, Robert E. Briggs, Fred M. Tatum, W. Edward Swords, Cristina De Castro, Antonio Molinaro, Thomas J. Inzana

AUTHOR CORRECTION Correction for Nguyen et al., “Bacteriophage Transcytosis Provides a Mechanism e02207-17 To Cross Epithelial Cell Layers” Sophie Nguyen, Kristi Baker, Benjamin S. Padman, Ruzeen Patwa, Rhys A. Dunstan, Thomas A. Weston, Kyle Schlosser, Barbara Bailey, Trevor Lithgow, Michael Lazarou, Antoni Luque, Forest Rohwer, Richard S. Blumberg, Jeremy J. Barr

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