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Part 2B - Annex I

Annex I

EXTRACT FROM THE GUIDANCE LIST OF BIOLOGICAL AGENTS

The hazard groups of all classified as biological agents are given below in this extract from the Second Supplement to the ACDP publication “Categorisation of biological agents according to hazard and categories of containment” (4th edition, 1995). Footnotes and abbreviations are given at the end of the list.

Hazard Group 3 Hazard Group 4 Arenaviridae Arenaviridae Old World Lymphocytic choriomeningitis Old World Lassa fever Mopeia

New World Guanarito New World Flexal Junin Machupo Bunyaviridae Sabia Akabane Germiston Bunyaviridae Oropouche Nairoviruses Crimean/Congo haemorrhagic fever Hantaviruses Belgrade (Dobrava) Hantaan (Korean haemorrhagic Ebola Reston fever) Ebola Siena Seoul Ebola Sudan Sin Nombre (formerly Muerto Canyon) Ebola Zaire Marburg Nairoviruses: Bhanja : Kyasanur forest disease V Phleboviruses: Omsk V Rift valley fever V Russian spring summer encephalitis V : Hepatitis E2 : Nipah Flaviviridae: Flaviviruses : Dengue viruses Types 1-4 Herpesvirus simiae (B ) Hepatitis G D Israel turkey meningitis Japanese B encephalitis V Variola1 (major and minor) V Murray Valley encephalitis Rocio Unclassified Viruses Sal Vieja Equine morbillivirus San Perlita Spondweni St. Louis encephalitis Wesselsbron

Issued: March 2000 Part 2B - Annex I

West Nile fever Bovine Spongiform Encephalopathy (BSE) Yellow fever V and other related animal TSEs D Creutzfeldt-Jakob disease2 D Tick-borne virus group Variant Creutzfeldt-Jakob disease D Absettarov V Fatal famillial insomnia D Hanzalova V Gerstmann-Sträussler- Hypr V Scheinker syndrome2 D Kumlinge Kuru2 D Louping ill V Negishi Hazard Group 2 Powassan Hepatitis C group Viruses Hepatitis C2 D Arenaviridae Old World Ippy Hepatitis B2 VD Mobala Other LCM-Lassa complex Hepatitis D (delta)2 VD viruses

Poxviridae New World Amapari V Latino Parana Retroviridae Pichinde Human immunodeficiency viruses2 Tamiami Human T-cell lymphotropic viruses (HTLV) types 1 and 22 D Astroviridae Simian immunodeficiency virus3 Bunyaviridae Bunyamwera Piry California encephalitis Rabies V Hantaviruses Prospect Hill Togaviridae Puumala Other Hantaviruses Nairoviruses Eastern equine encephalomyelitis V Hazara Everglades Phleboviruses Getah Sandfly fever Mayaro Toscana Middleburg Uukuviruses Mucambo Other bunyaviridae known to be Ndumu pathogenic Sagiyama Tonate Caliciviridae Venezuelan equine Norwalk encephalomyelitis Other Caliciviridae Western equine encephalomyelitis V

Unclassified viruses Flaviviridae Borna disease virus Other Flaviviruses known to be Blood-borne hepatitis viruses pathogenic not yet identified D Herpesviridae Unconventional agents4 Associated with the Transmissable Spongiform Encephalopathies Epstein-Barr virus (TSEs) types 1 and 2 Issued: March 2000 Part 2B - Annex I

Herpesvirus varicella-zoster Ross river Human herpesvirus type 6-HHV6 Semliki forest Human herpesvirus type 7-HHV7 Sindbis Human herpesvirus type 8-HHV8 D Other known alphaviruses

Orthomyxoviridae Rubiviruses Influenza types A, B and C V V

Tick-borne Toroviridae Dhori and Thogoto *************************** Papovaviridae BK and JC viruses Notes & abbrevations Human papillomaviruses Simian virus 40 (SV40) 1 All strains including whitepox virus. Work with Paramyxoviridae these viruses should not be carried out in the V United Kingdom. Mumps V Newcastle disease 2 Refer to the exemption certificate on page 136 of Parainfluenza (Types 1 to 4) the Categorisation of biological agents. Respiratory syncytial virus 3 At present there is no evidence of disease in humans caused by Simian T-cell lymphotropic Human parvovirus (B19) virus (STLV). As a precaution Containment Level 3 is recommended for work with them. Picornaviridae Acute haemorrhagic 4 There is no evidence in humans of infections conjunctivitis virus (AHC) caused by the agents responsible for other Coxsackieviruses animal TSEs. Nevertheless, the containment Echoviruses measures for agents catagorised in hazard group Polioviruses V 3 are recommended as a precaution for Rhinoviruses V larboratory work, except for laboratory work Hepatoviruses relating to an identified agent of scrapie, where Hepatitis A (human containment level 2 is sufficient. enterovirus type 72) V Poxviridae 5 Including strains isolated from domestic cats and G exotic species, e.g. elephants, cheetah. Cowpox5 G Milker's nodes virus G 6 Including strains originally classified as virus G rabbitpox. Vaccinia6 The notations used in this extract have the Yatapox (Tana & Yaba) following meaning:

Reoviridae D: list of workers exposed to this biological agent Coltivirus to be kept for 40 years following the last known Human rotaviruses exposure; Orbiviruses G: gloves should be used; Reoviruses V: an effective vaccine is available.

Rhabdoviridae Duvenhage V Vesicular stomatitis

Togaviridae Alphaviruses Bebaru O'nyong-nyong Issued: March 2000