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FOR INTERNAL USE ONLY Contacted: Approved: Physician: Denied: Attn: Prior Authorization Department Pharmacy: Returned: 10181 Scripps Gateway Court San Diego, CA 92131 Phone: (800) 347-5841 Patient: ID # Fax: (877) 606-0728 Medication Request Form MedImpact Healthcare Systems, Inc. Instructions: This form is to be used by participating physicians and providers to obtain coverage for a non-formulary drug for which there is no suitable alternative available. Please complete this form and fax to Medlmpact Healthcare Systems, Inc. at (877) 606-0728 or please call (800) 347-5841 with this information. If you have any questions regarding this process, please contact Medlmpact's Customer Service at (800) 347-5841. Review Criteria: The following guidelines are used in reviewing medication requests: 1. The use of Formulary Drug Products is contraindicated in the patient. 2. The patient has failed an appropriate trial of Formulary or related agents. 3. The choices available in the Formulary are not suited for the present patient care need and the drug selected is required for patient safety. 4. The use of a Formulary Drug Product may provoke an underlying medical condition, which would be detrimental to patient care Medication Request Information (please complete each section of this form prior to transmittal): PATIENT NAME (REQUIRED): PATIENT'S HEALTH PLAN (REQUIRED): PATIENT ID # (REQUIRED): PHYSICIAN NAME/SPECIALTY: PATIENT HEIGHT AND WEIGHT (REQUIRED): PHYSICIAN ID#/DEA#: PATIENT DOB (REQUIRED): PHYSICIAN AREA CODE AND TELEPHONE NUMBER: DIAGNOSIS (REQUIRED): PHYSICIAN AREA CODE AND FAX NUMBER (REQUIRED): PHARMACY USED BY MEMBER: PHARMACY AREA CODE AND TELEPHONE NUMBER: DRUG REQUESTED: QUANTITY (PER MONTH): DOSE: LENGTH OF TREATMENT (PLEASE BE SPECIFIC): STRENGTH: DOSAGE FORM (e.g.• ORAL, INJECTION): REASON FOR MEDICATION REQUEST (PLEASE BE SPECIFIC, GIVE DETAIL): OTHER MEDICATIONS TRIED AND/OR FAILED (PLEASE BE SPECIFIC, GIVE DETAIL INCLUDING REASON FOR FAILURE): OTHER PERTINENT HISTORY (RELATIVE OR PERTAINING TO THIS REQUEST): PROVIDER NAME AND SIGNATURE: W,/W WĂŐĞϯŽĨϭϱϮ Commercial Formulary Drug Name Tier Requirements/Limits ALLERGY ALLERGENIC EXTRACTS,
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    REVIEW Gonadotropin therapy in assisted reproduction: an evolutionary perspective from biologics to biotech Roge´rio de Barros F. Lea˜ o, Sandro C. Esteves Andrology & Human Reproduction Clinic (ANDROFERT), Referral Center for Male Reproduction, Campinas/SP, Brazil. Gonadotropin therapy plays an integral role in ovarian stimulation for infertility treatments. Efforts have been made over the last century to improve gonadotropin preparations. Undoubtedly, current gonadotropins have better quality and safety profiles as well as clinical efficacy than earlier ones. A major achievement has been introducing recombinant technology in the manufacturing processes for follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin. Recombinant gonadotropins are purer than urine- derived gonadotropins, and incorporating vial filling by mass virtually eliminated batch-to-batch variations and enabled accurate dosing. Recombinant and fill-by-mass technologies have been the driving forces for launching of prefilled pen devices for more patient-friendly ovarian stimulation. The most recent developments include the fixed combination of follitropin alfa + lutropin alfa, long-acting FSH gonadotropin, and a new family of prefilled pen injector devices for administration of recombinant gonadotropins. The next step would be the production of orally bioactive molecules with selective follicle-stimulating hormone and luteinizing hormone activity. KEYWORDS: Gonadotropins; Ovulation Induction; Assisted Reproductive Techniques; Systematic Review.
  • Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management

    Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management

    Pharmacology & Pharmacy, 2012, 3, 291-294 291 http://dx.doi.org/10.4236/pp.2012.33038 Published Online July 2012 (http://www.SciRP.org/journal/pp) Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management Ashish Rastogi1,2, Salomon Stavchansky2, Phillip D. Bowman1* 1US Army Institute of Surgical Research, Fort Sam Houston, USA; 2Division of Pharmaceutics, College of Pharmacy, The Univer- sity of Texas at Austin, Austin, USA. Email: [email protected], *[email protected] Received March 20th, 2012; revised April 29th, 2012; accepted May 11th, 2012 ABSTRACT Continuous delivery of local anesthetics might be useful for management of localized and chronic pain. Controlled re- lease injectable anesthetics have been developed but they can deliver the drug for only few days and the release is not zero-order. A drug delivery system (DDS) consisting of a perforated reservoir for drug containment and release and its potential for management of chronic pain is described. Proof of principle is detailed for long-term zero order delivery of butamben. In this study, the DDS was a polyimide tube with a 0.20 mm hole and butamben release was evaluated in vitro. It is envisioned that the DDS could be implanted in proximity to a nerve, enervating the pain source, for long-term control of chronic pain. Keywords: Controlled Release; Prolonged Drug Delivery; Pain Management; Butamben 1. Introduction operated, and not suitable for everyone [9]. Persistent cerebrospinal fluid leak during its insertion is also a Long-term drug therapy for pain management is chal- known complication [10].
  • 15-CETY-040, Cetecaine Gel Sell Sheet FA No Crops

    15-CETY-040, Cetecaine Gel Sell Sheet FA No Crops

    Cetacaine® TOPICAL ANESTHETIC GEL (Benzocaine 14.0%, Butamben 2.0%, Tetracaine Hydrochloride 2.0%) Proven more effective than benzocaine alone1 Cetacaine® Topical Anesthetic Gel is a fast-acting, long-lasting prescription topical anesthetic. Applied directly to the mucous membrane, Cetacaine is primarily used to control pain and ease discomfort at the application site. The protective pump-top jar controls the amount of Cetacaine dispensed while keeping the remaining contents safe from cross contamination. The outside lid helps to keep the pump surface clean and intact. Please see the Brief Summary of the Prescribing Information on the reverse side. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Cetacaine Gel is indicated for anesthesia of all Description Size Item No. accessible mucous membrane except the eyes. Cetacaine Topical Anesthetic Gel 32 g 0217 Cetacaine is not for injection. Features & Benefits • Onset of action: Approximately 30 seconds* • Applies evenly and consistently, tissue need not be dried • Duration of action: 30-60 minutes* • Reacts with body temperature to melt and absorb quickly into tissue • Controls pain and eases discomfort at the application site • Made in USA • Pleasant strawberry flavor • Study shows Cetacaine’s triple formula is more effective than • Lubricating qualities Benzocaine alone Important Safety Information • On rare occasions, methemoglobinemia has been reported in • The most common adverse reaction caused by local anesthetics is connection with the use of benzocaine-containing products. contact dermatitis characterized by erythema and pruritus that If a patient becomes cyanotic, treat appropriately to counteract may progress to vesiculation and oozing.
  • Infertility Therapy Reference Number: CP.CPA.261 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Medicaid – Medi-Cal Revision Log

    Infertility Therapy Reference Number: CP.CPA.261 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Medicaid – Medi-Cal Revision Log

    Clinical Policy: Infertility Therapy Reference Number: CP.CPA.261 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Medicaid – Medi-Cal Revision Log See Important Reminder at the end of this policy for important regulatory and legal information. Description The following are gonadotropins requiring prior authorization: Menotropins (Menopur®), Follitropin alpha, recombinant (Gonal-F® RFF), Follitropin beta, recombinant (Follistim®-AQ), Urofollitropin (Bravelle®), Choriogonadotropin alfa (Ovidrel®), Human chorionic gonadotropin (Novarel®, Pregnyl®), Ganirelex acetate, Cetrorelix (Cetrotide®). FDA approved indication Menopur is indicated for development of multiple follicles and pregnancy in ovulatory women as part of an Assisted Reproductive Technology (ART) cycle. Gonal-F RFF is indicated: • For induction of ovulation and pregnancy in oligo-anovulatory women in whom the cause of infertility is functional and not due to primary ovarian failure. • For development of multiple follicles in ovulatory women as part of an Assisted Reproductive Technology (ART) cycle. Follistim AQ is indicated: • In women for: Induction of ovulation and pregnancy in anovulatory infertile women in whom the cause of infertility is functional and not due to primary ovarian failure. • In women for: Pregnancy in normal ovulatory women undergoing controlled ovarian stimulation as part of an In Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) cycle. • In men for: Induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism (HH) in whom the cause of infertility is not due to primary testicular failure. Bravelle is indicated: • For induction of ovulation in women who have previously received pituitary suppression. • For development of multiple follicles as part of an Assisted Reproductive Technology (ART) cycle in ovulatory women who have previously received pituitary suppression.
  • Adverse Health Effects of Heavy Metals in Children

    Adverse Health Effects of Heavy Metals in Children

    TRAINING FOR HEALTH CARE PROVIDERS [Date …Place …Event …Sponsor …Organizer] ADVERSE HEALTH EFFECTS OF HEAVY METALS IN CHILDREN Children's Health and the Environment WHO Training Package for the Health Sector World Health Organization www.who.int/ceh October 2011 1 <<NOTE TO USER: Please add details of the date, time, place and sponsorship of the meeting for which you are using this presentation in the space indicated.>> <<NOTE TO USER: This is a large set of slides from which the presenter should select the most relevant ones to use in a specific presentation. These slides cover many facets of the problem. Present only those slides that apply most directly to the local situation in the region. Please replace the examples, data, pictures and case studies with ones that are relevant to your situation.>> <<NOTE TO USER: This slide set discusses routes of exposure, adverse health effects and case studies from environmental exposure to heavy metals, other than lead and mercury, please go to the modules on lead and mercury for more information on those. Please refer to other modules (e.g. water, neurodevelopment, biomonitoring, environmental and developmental origins of disease) for complementary information>> Children and heavy metals LEARNING OBJECTIVES To define the spectrum of heavy metals (others than lead and mercury) with adverse effects on human health To describe the epidemiology of adverse effects of heavy metals (Arsenic, Cadmium, Copper and Thallium) in children To describe sources and routes of exposure of children to those heavy metals To understand the mechanism and illustrate the clinical effects of heavy metals’ toxicity To discuss the strategy of prevention of heavy metals’ adverse effects 2 The scope of this module is to provide an overview of the public health impact, adverse health effects, epidemiology, mechanism of action and prevention of heavy metals (other than lead and mercury) toxicity in children.