ACKNOWLEDGEMENTS –Italy Meeting Israel–Italy Meeting AUTOIMMUNITY & RHEUMATOLOGY AUTOIMMUNITY & RHEUMATOLOGY

Main Sponsor See you in The 3RD Israel-Italy Meeting WELCOME MESSAGE Siena! on Advances in Autoimmunity & Rheumatology

Dear Friends and Colleagues from Italy and Israel, The Maylowitz-Razin Congress of Autoimmunity This is the third Israel-Italy Meeting on Advances in Autoimmunity and Sponsors Rheumatology. A third meeting is not an incidental meeting. It indicates tradition. October 23–24, 2014 Moreover, we are already planning the 4th Israel-Italy Meeting which will take place in Siena on September 27-29, 2015 and will be organized by Prof. Mauro Galeazzi. These meetings are a great opportunity for exchange of ideas, which on many occasions materialize in real collaborations, common papers and projects. Likewise, the meetings lead to exchange of young and senior physicians and researchers between our centers and countries, further strengthening the ties that bond us. Let us hope that the young fellows will continue this wonderful tradition Zabludowicz Center for for many years to come. Autoimmune Diseases,

We welcome all of you with open arms in our small country and hope that you will The Bunnie Maylowitz- enjoy not only the scientific interaction but also the cultural events that we have Razin Outpatient Clinic planned for you. , Tel-Hashomer, Israel Grazie mille,

Yours always,

Yehuda Shoenfeld MD, FRCP (hon), MaACR Presidents: Yehuda Shoenfeld (Israel)

grants Roberto Perricone (Italy) Coordination and Registration 4th Israel-Italy Meeting on Elias Toubi (Israel) Please confirm your participation by email: [email protected] Advances in Autoimmunity Tel: 972-54-6787809 Anna Varsanyi and Rheumatology Project Coordinator September 27-29, 2015 Israel–Italy Meeting Siena, Italy AUTOIMMUNITY & RHEUMATOLOGY FACULTY SCIENTIFIC PROGRAM Israel–Italy Meeting AUTOIMMUNITY & RHEUMATOLOGY Thursday – October 23, 2014 Friday – October 24, 2014 Mahmoud Abu-Shakra, Department of Medicine D, Serena Colafrancesco, Department of Internal Avi Livneh, Department of Internal Medicine H, Cristina Rosario, Zabludowicz Center for 7:30-8:00 Coffee & Faculty of Health Sciences, Medicine and Medical Specialities, Rheumatology Sheba Medical Center, Tel Hashomer, Israel Autoimmune Diseases, Sheba Medical Center, Tel 8:00 – 8:30 Coffee break Ben Gurion University of the Negev, Beer Sheva, Unit, Sapienza University of Rome, Italy; Hashomer, Israel Welcome SESSION 5: FRONTIERS IN AUTOIMMUNITY Israel Zabludowicz Center for Autoimmune Diseases, Caludio Lunardi, Department of Medicine, Mr. Itzhak Razin: a word on B. Maylowitz Prof. Zeev Rotstein, Head of Sheba Medical Center R. Mader (Israel), C. Bonaguri (Italy), Sheba Medical Center, Tel Hashomer, Israel University of Verona, Verona, Italy Piercarlo Sarzi-Puttini, Rheumatology Unit, L. Chairs Nancy Agmon-Levin, Zabludowicz Center for Sacco University Hospital, Milan, Italy 8:00-8:15 Prof. Ehud Grossman, Dean of the Sackler Faculty of Medicine, University M. Ehrenfeld (Israel) Autoimmune Diseases, Sheba Medical Center, Tel Maria Giovanna Danieli, Department of Clinical Reuven Mader, Rheumatic Diseases Unit, Ha’ Prof. Ori Elkayam, President of the Israeli Society of Rheumatology Dr. Nancy Agmon-Levin, President of the Israeli Society of Allergy and Clinical Immunology Yaakov Naparstek: Prozumab-an anti HSP 60 Emek Medical Center, ; B. Rappaport Faculty Carlo Selmi, Division of Rheumatology and Clinical Hashomer, Israel and Molecular Science, Polytechnic University of Representatives of the Embassy of Italy in Israel 8:30-8:45 antibody suppresses autoimmune inflammatory Marche & United Hospitals, Ancona, Italy of Medicine, The Technion Institute of Technology, Immunology, Humanitas Research Hospital, diseases , Israel Rina Aharoni, Department of Immunology, The Rozzano, Milan, Italy Laura Andreoli: Belimumab for the treatment of SESSION 1: CUTTING EDGE IN SESSION 3: FEDERICO: PEBBLES IN 8:45-9:00 Weizmann Institute of Science, , Israel Caterina De Carolis, Obstetrics and Gynecology II, refractory SLE patients: does it work in 'real life'? San Giovanni Addolorata Hospital, Rome, Italy Yoseph Mekori, Sackler Faculty of Medicine, Tel- Yehuda Shoenfeld, Zabludowicz Center for AUTOIMMUNITY AUTOIMMUNITY Howard Amital, Department of Medicine B, Sheba Aviv University, Tel-Aviv, Israel Autoimmune Diseases, Sheba Medical Center, Tel Chairs Y. Mekori (Israel), E. Toubi (Israel), R. Gerli (Italy) P. Langevitz (Israel), N. Bizzaro (Italy), Caterina De Carolis: War and Peace at the Chairs Medical Center, Tel Hashomer, Israel Andrea Doria, Division of Rheumatology, University Hashomer, Israel; Incumbent of the Laura Schwarz- P.L. Meroni (Italy) 9:00-9:15 feto-placental front line: recurrent spontaneous Andrea Doria: Anti-PTX3 antibodies in lupus abortion Alessandra Melegari, Diagnostic Laboratory 8:15-8:30 of Padova, Padova, Italy Kipp Chair for Research of Autoimmune Diseases, nephritis Carlo Perricone: The autoimmune side of Laura Andreoli, Rheumatology and Clinical Department, NOSAE Hospital, Modena, Italy 13:00 -13:10 Merav Lidar: Cryopyrin Associated Periodic Fever Tel-Aviv University, Israel rheumatic fever 9:15-9:30 Tomer Bashi: Helminthes derivative for treating Syndrome (CAPS) Immunology, Department of Clinical and Mauro Galeazzi, Rheumatology Unit, 8:30-8:45 Pierluigi Meroni, Division of Rheumatology, autoimmune diseases Mariele Gatto: Serpin B3 ameliorates lupus in Experimental Sciences, University of Brescia, Italy Research Center of Systemic Autoimmune and Alessandra Soriano, Periodic Fever Research 13:10 -13:20 Mathilde Versini: Obesity in autoimmune Department of Clinical Sciences and Community NZB/W and MRL-lpr mice 9:30-9:45 Autoinflammatory Diseases, Policlinico Le Scotte, Centre, National Reference Centre for FMF, Catholic Claudio Lunardi: Modulation of adaptive diseases: not a passive bystander Health, University of Milan, Milan, Italy Maria Arango, Zabludowicz Center for Autoimmune University of Siena, Siena, Italy University of the Sacred Heart, Rome, Italy; 8:45-9:00 immune response following intravenous 13:20 -13:30 Cristina Rosario: Hyperferritinemic syndrome 9:45-10:15 Coffee break Diseases, Sheba Medical Center, Tel Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, immunoglobulin therapy in CVID Yaakov Naparstek, Department of Medicine, Serena Colafrancesco: SCD163 in adult onset Bogota, Colombia Mariele Gatto, Division of Rheumatology, University Sheba Medical Center, Tel Hashomer, Israel Maria Arango: Narcolepsy: A new autoimmune 13:30 -13:40 still’s disease: a biomarker for macrophage Hadassah University Hospital, Hebrew University- 9:00-9:15 of Padova, Padova, Italy disease activation related to hyperferritinemia Ruth Arnon, Department of Immunology, The Hadassah Medical School, , Israel SESSION 6: INFECTION, VACCINE & Angela Tincani, Rheumatology and Clinical IMMUNOREGULATION IN AUTOIMMUNITY Weizmann Institute of Science, Rehovot, Israel Chiara Gelardi, Department of Clinical and Roberto Perricone: Hereditary angioedema and 13:40 -13:50 Maurizio Rinaldi: ASCA and autoimmunity Dafna Paran, Department of Rheumatology, Immunology, Spedali Civili and University of 9:15-9:30 Molecular Science, Polytechnic University of Marche autoimmunity G. Valesini (Italy), R. Arnon (Israel), C. Selmi Sourasky Medical Center, Tel Aviv, Israel Brescia, Brescia, Italy 13:50 - 14:00 Shaye Kivity: CNS lupus autoantibodies Chairs Tomer Bashi, Zabludowicz Center for Autoimmune & United Hospitals, Ancona, Italy Zahava Vadasz: New potential biomarkers for (Italy) 9:30-9:45 14:00 -14:30 Coffee break Diseases, Sheba Medical Center, Tel Hashomer, Israel Roberto Perricone, Rheumatology, Allergology Elias Toubi, Clinical Immunology, Bnai Zion Medical disease activity and fibrosis in systemic sclerosis Elias Toubi: B regulatory cells: A big family of Roberto Gerli, Department of Medicine, Rheumatology 10:15-10:30 and Clinical Immunology, Department of Internal Center, Haifa, Israel 9:45-10:15 Coffee break regulatory cells rather than one subset of cells Giorgia Bizzaro, Zabludowicz Center for Unit, University of Perugia, Perugia, Italy Medicine, University of Rome Tor Vergata, Italy SESSION 4: PREVENTION & INNOVATIVE 10:30-10:45 Elon Pras: Fishing for genes in autoimmunity Autoimmune Diseases, Sheba Medical Center, Tel Tommaso Trenti, Institute of General Medical Clinic THERAPY IN AUTOIMMUNITY Hashomer, Israel; Italy Smadar Gertel, Zabludowicz Center for Autoimmune and Medical Therapy III, University of Modena, Italy SESSION 2: RHEUMATOLOGY: NOVEL Irun Cohen: Arresting beta-cell destruction Carlo Perricone, Rheumatology, Department of A. Puccetti (Italy), T. Trenti (Italy), D. Roccatello Diseases, Sheba Medical Center, Tel Hashomer, Israel Internal Medicine, Sapienza University of Rome, ASPECTS IN DIAGNOSTICS & THERAPY Chairs 10:45-11:00 in T1D: Mobilizing autoimmunity to treat Nicola Bizzaro, Laboratory of Clinical Pathology, Zahava Vadasz, Clinical Immunology, Bnai Zion (Italy) autoimmunity Rome, Italy G. Zandman-Goddard (Israel), A. Livneh (Israel), Hospital San Antonio of Tolmezzo, Italy Aaron Kessel, Bnai-Zion Medical Center, Faculty of Chairs Medical Center, Haifa, Israel M. G. Danieli (Italy) 14:30 -14:45 Giorgia Bizzaro: Vitamin D and autoimmunity 11:00-11:15 Dan Buskila: Rheumatic manifestations of HIV Medicine, Technion Institute of Technology, Haifa, Elon Pras, The Danek Gertner Institute of Human Smadar Gertel: Pathogenic immune response Miri Blank, Zabludowicz Center for Autoimmune Israel Guido Valesini, Department of Clinical and Medical Mauro Galeazzi: A phase Ib clinical trial with Nancy Agmon-Levin/L. Tomljenovic: HBV and Genetics, Sheba Medical Center, Tel Hashomer, Israel; induced by anti-citrullinated protein Diseases, Sheba Medical Center, Tel Hashomer, Israel Therapy, Rheumatology, Sapienza University of 10:15 -10:30 dekavil (F8-IL10), for the treatment of rheumatoid 11:15-11:30 Gardasil vaccinations of healthy and NZB/W F1 Zabludowicz Center for Autoimmune Diseases, arthritis, used in combination with methotrexate 14:45 -15:00 autoantibodies (ACPA) in human rheumatoid mice induce behavioral changes Shaye Kivity, Department of Medicine A, Sheba Sheba Medical Center, Tel Hashomer, Israel Rome, Rome, Italy arthritis (RA) and chronic obstructive pulmonary Chiara Bonaguri, Diagnostic Laboratory Medical Center, Tel Hashomer, Israel; Zabludowicz Miri Blank: Domain-I/beta2GPI tolerogenic disease (COPD) patients lymphocytes Rina Aharoni: Enhanced myelination in Department, Parma Hospital, Parma, Italy Center for Autoimmune Diseases, Sheba Medical Antonio Puccetti, Department of Experimental Mathilde Versini, The Zabludowicz Center for 10:30 -10:45 dendritic cells attenuate experimental 11:30-11:45 autoimmunity and in normal development Alessandra Soriano: Who should not be induced by glatiramer acetate Center, Tel Hashomer, Israel Medicine, University of Genova and Institute G. Autoimmune Diseases, Sheba Medical Center, Tel- antiphospholipid syndrome 15:00 -15:15 Dan Buskila, Department of Medicine H, Soroka vaccinated? Gaslini, Genova, Italy Hashomer, Israel; Department of Internal Medicine, 10:45- 11:00 Nicola Bizzaro: Prediction of autoimmunity Aharon Kessel: Toll-like receptor 9 expression on Medical Center & Faculty of Health Sciences, Ben Piercarlo Sarzi-Puttini: New biologic treatments 11:45-12:00 Pnina Langevitz, Rheumatalogy Unit, Sheba Archet-1 Hospital, University of Nice-Sophia- 15:15 -15:30 B cells from inflammatory bowel disease patients Gurion University of the Negev, Beer Sheva, Israel Medical Center, Tel-Hashomer, the Sackler Faculty Antipolis, Nice, France 11:00-11:15 Mahmoud Abu Shakra: Sepsis in SLE and RA in psoriatic arthritis Maurizio Rinaldi, Rheumatology, Allergology Joab Chapman: Advances in understanding the of Medicine, Tel Aviv University, Tel Aviv, Israel; and Clinical Immunology, Department of Internal Angela Tincani: Pregnancy in APS: can we Howard Amital: Understanding the aspects 11:15-11:30 12:00-12:15 antiphospholipid syndrome as a disease of the Joab Chapman, Department of Neurology and Zabludowicz Center for Autoimmune Diseases, Gisele Zandman-Goddard, The Zabludowicz progress in the patients management? of diagnosis and compliance of patients with Medicine, University of Rome Tor Vergata, Rome, 15:30 -15:45 brain Sagol Neuroscience Center, Sheba Medical Center, Sheba Medical Center, Tel Hashomer, Israel Italy; Zabludowicz Center for Autoimmune Diseases, Center For Autoimmune Diseases, Sheba Medical fibromyalgia in a large Health Maintenance Alessandra Melegari: Harmonization of Dafna Paran: Impaired learning and memory Tel-Hashomer Sheba Medical Center, Tel Hashomer, Israel Center, Tel-Hashomer, Sackler Faculty of Medicine Organization (HMO) in Israel 11:30-11:45 Autoimmune Diagnostics with ANA: approach 12:15-12:30 abilities in SLE - lessons from advanced brain Merav Lidar, Rheumatalogy Unit, Sheba Medical Tel-Aviv University, Israel; Department of Medicine and clinical relevance Chiara Gelardi: Subcutaneous immunoglobulin in Irun Cohen, Department of Immunology, The 15:45 -15:55 imaging studies Center, Tel-Hashomer, the Sackler Faculty of Dario Roccatello, Research Centre for Clinical C, , , Israel idiopathic inflammatory myositis Weizmann Institute of Science, Rehovot, Israel Roberto Gerli: New perspectives in diagnosis and Medicine, Tel Aviv University, Tel Aviv, Israel; Immunology and Immunopathology and 11:45-12:00 12:30-13:30 Lunch break treatment of primary Sjogren’s syndrome 16:00 Adjourn Zabludowicz Center for Autoimmune Diseases, Documentation of Rare Diseases (CMID), University

Sheba Medical Center, Tel Hashomer, Israel of Torino, Turin, Italy 12:00 -13:00 Lunch break