PH76-FrontMatter ARI 22 January 2014 18:37 Annu. Rev. Physiol. 2014.76:1-20. Downloaded from www.annualreviews.org Access provided by Stanford University - Main Campus Robert Crown Law Library on 06/29/16. For personal use only. PH76CH01-Roederer ARI 11 January 2014 11:18 A Conversation with Leonard and Leonore Herzenberg Leonard A. Herzenberg,1,∗ Leonore A. Herzenberg,1 and Mario Roederer2 1Department of Genetics, Stanford University, Stanford, California 94305 2ImmunoTechnology Section, Vaccine Research Center, National Institutes of Health, Baltimore, Maryland 20892; email:
[email protected] Annu. Rev. Physiol. 2014. 76:1–20 Keywords First published online as a Review in Advance on flow cytometry, hybridomas, immunology, technology August 19, 2013 Annu. Rev. Physiol. 2014.76:1-20. Downloaded from www.annualreviews.org The Annual Review of Physiology is online at Abstract http://physiol.annualreviews.org Leonard and Leonore Herzenberg have left an indelible mark on the fields This article’s doi: of immunology and cell biology, both in research and clinical aspects. They 10.1146/annurev-physiol-021113-170355 are perhaps best known for developing the technologies of fluorescence flow Copyright c 2014 by Annual Reviews. cytometry and hybridomas. Over six decades, they made a number of impor- All rights reserved tant and fundamental discoveries in lymphocyte biology by applying these Access provided by Stanford University - Main Campus Robert Crown Law Library on 06/29/16. For personal use only. ∗ November 5, 1931–October 27, 2013 technologies. During this era, they immersed themselves in the sociopoliti- cal environment, interjecting scientific rationale into public discourse about McCarthyism, nuclear fallout, war, genetics, and other politically charged topics.