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Programme and Exhibition Guide 2013 Programme and Exhibition Guide 2013 Programme and Exhibition Guide Programme 3–6 November 2013 The BT Convention Centre, Liverpool, UK 2013 Acknowledgements: NCRI partners The Scientific Committee and organising team are grateful to all the NCRI partners for their continuing commitment to the concept of a multidisciplinary cancer conference and for their financial support. Association of the British Association for International Breakthrough Breast Cancer Biotechnology and Biological Pharmaceutical Industry Cancer Research www.breakthrough.org.uk Sciences Research Council www.abpi.org.uk www.aicr.org.uk www.bbsrc.ac.uk Breast Cancer Campaign Cancer Research UK Scottish Executive Children with Cancer UK www.breastcancercampaign.org www.cancerresearchuk.org Chief Scientist Office www.childrenwithcancer.org.uk www.cso.scot.nhs.uk Department of Health Economic and Social Leukaemia & Lymphoma Research Ludwig Institute for www.dh.gov.uk Research Council www.leukaemialymphomaresearch.org.uk Cancer Research www.esrc.ac.uk www.ludwig.ox.ac.uk Macmillan Cancer Support Marie Curie Cancer Care Medical Research Council Northern Ireland Health and www.macmillan.org.uk www.mariecurie.org.uk www.mrc.ac.uk Social Care Research and Development Office www.publichealth.hscni.net Prostate Cancer UK Roy Castle Lung Cancer Foundation Tenovus Your Cancer Charity Welsh Government - National www.prostate-cancer.org.uk www.roycastle.org www.tenovus.org.uk Institute for Social Care and Health Research www.nischr.org.uk Wellcome Trust Yorkshire Cancer Research www.wellcome.ac.uk www.yorkshirecancerresearch.org.uk NCRI Cancer Conference Programme and Exhibition Guide 2013 Map of the BT Convention Centre Side view of venue Cityside entrance: Registration Riverside Hotels and car parking area balcony First floor Ground floor Galleria Galleria Lower floor Hall 2 Exhibition, poster sessions, Riverside entrance: social media hub and refreshment area Shuttle buses and taxis Plenary lectures Hall 1A 14 1B 1C 13 3B 11C 11B 10 7 4B 3A 12 9 6 11A 4A 8 5 Registration area 15 16 Contents INTRODUCTION TO THE CONFERENCE TUESDAY 5 NOVEMBER 2 Welcome from the Chairs 84 Programme at a glance 4 Scientific Committee 88 Plenary abstracts 5 2013 Conference supporters 90 Clinical Trials Showcase abstracts 94 Symposia 96 Symposia abstracts 105 Workshops PLANNING YOUR CONFERENCE 108 Proffered paper sessions EXPERIENCE 112 Proffered paper session abstracts 7 Useful information 137 Parallel sessions 10 Choosing the right session 140 Parallel session abstracts 11 Session themes 12 The Royal College of Radiologists at the Conference WEDNESDAY 6 NOVEMBER 13 Networking 154 Programme at a glance 156 Plenary abstracts 157 Parallel sessions SUNDAY 3 NOVEMBER 160 Parallel session abstracts 16 Programme at a glance 17 Plenary abstracts 18 Workshops EXHIBITION 172 Floorplan 174 Exhibitor list MONDAY 4 NOVEMBER 176 Exhibitor information 20 Programme at a glance 24 Plenary abstracts 26 Symposia ACKNOWLEDGEMENTS 28 Symposia abstracts 34 Workshops SPEAKER INDEX 38 Proffered paper sessions 42 Proffered paper session abstracts ACRONYMS 66 Parallel sessions 69 Parallel session abstracts NOTES Welcome from the Chairs Message from the Chair of the National Cancer Research Institute Dr Harpal S Kumar Chair of the National Cancer Research Institute I am delighted to welcome you to the ninth NCRI Cancer Conference in my first year as Chair of the NCRI. This next Conference plays a very important role in bringing researchers together from the UK and internationally. Over the four days, you will have the opportunity to take part in sessions and meet with colleagues from across the world and across the spectrum of cancer research: basic science, clinical studies, translational science, palliative care and end of life care. Each year we attract established experts, along with students and other early career researchers from a range of disciplines, as well as patients and carers with an interest and involvement in research. This diversity is one of our strengths. With the huge range of work on display, everyone has the opportunity to learn something new. A group of 50 A level students from the Liverpool area will also be with us on Tuesday to take part in a schools programme and we hope that some of them will be inspired to follow a career in cancer research. The NCRI Partnership is comprised of 21 government and charity funders of research together with the Association of British Pharmaceutical Industry (ABPI). We aim to coordinate research and funding strategies, for the ultimate benefit of patients and public. Communication is the key to this, whether it be among scientists and clinicians, among funders, with policy-makers, or the general public. NCRI has many initiatives promoting communication, coordination and collaboration of which this annual Conference is perhaps the most visible. Find out more about NCRI and our other initiatives by visiting our stand in the exhibition hall. The Conference is a joint effort from many people. I would like to thank the sponsors and exhibitors, including the NCRI partners, who help to make the event happen. I would also like to extend my thanks to the Scientific Committee for developing an inspiring programme, and of course the speakers themselves who have travelled from all over the world to come and speak in Liverpool. Finally I am grateful to the Conference team within the NCRI Secretariat for their excellent organisation. Thank you to everyone for making our Conference such a great success. Enjoy your Conference experience. Harpal S Kumar Chair of the National Cancer Research Institute 2 conference.ncri.org.uk Welcome from the Chairs Message from the Chair of the Scientific Committee Professor Gerard Evan Chair of the 2013 Scientific Committee Head of Department of Biochemistry, University of Cambridge, UK On behalf of the Scientific Committee, it is a pleasure to welcome you to the vibrant city of Liverpool and the ninth NCRI Cancer Conference. If you want to understand cancer, and to help people with cancer, then you are in the right place. Colleagues on the Scientific Committee deserve my gratitude for building a programme combining the best international research with opportunities for interaction and networking. There are several types of talks for you to choose from, such as plenary lectures, parallel sessions, symposia, and proffered paper sessions. Talks and posters cover the whole spectrum of cancer research, from basic research and translational science, through to clinical application in diagnosis and treatment, as well as sessions on survivorship, end of life care and health service research. We aim to challenge the way you think about your own research and its place within a broader context, contributing to an overall understanding of cancer and how best to help cancer patients. Amongst the busy programme there will be sessions aimed at surgeons, oncologists and scientists on Monday in a ‘Working together in surgery’ track. Plus, after the success of last year’s collaboration with the Royal College of Radiologists (RCR), some sessions on Tuesday have again been programmed in association with the RCR. Tuesday also sees the ever-popular Clinical Trials Showcase which provides updates on practice-changing trials, these events making this the essential day for clinicians to attend. Please also make time to visit exhibitors in Hall 2. There are more than 60 stands from different companies and organisations. Join us there in the breaks to hear about their latest products and services, and acknowledge their contribution to the Conference. Finally, if you use technology to help with your networking, sign up to the NCRI group on LinkedIn. There will also be a prize for the best tweet of the Conference for all you tweeters. Use #NCRI2013 and get tweeting. Wishing you an enjoyable and rewarding stay in Liverpool. Gerard Evan Chair of the 2013 Scientific Committee Head of Department of Biochemistry, University of Cambridge, UK conference.ncri.org.uk 3 Scientific Committee The NCRI is grateful to the Scientific Committee for their support in developing the programme and maintaining the high standards of this Conference. Chris Boshoff Richard Marais (2013 Vice Chair), (2014 Chair) Jane Cope Gerard Evan University College Cancer Research UK National Cancer (2013 Chair), University London Cancer Manchester Institute, Research Institute, of Cambridge, UK Institute, UK UK London, UK Caroline Dive Julian Downward Cancer Research UK Cancer Research UK Tom Haswell Fiona Hemsley Manchester Institute, London Research NCRI Consumer Liaison The Institute of Cancer UK Institute, UK Group, UK Research, London, UK Irene Higginson Kairbaan Cicely Saunders Hodivala-Dilke Danielle Horton Taylor Patrick Johnston Institute, King’s College Barts Cancer Institute, NCRI Consumer Liaison Queen’s University London, UK London, UK Group, UK Belfast, UK Greg Rubin Nazneen Rahman Wolfson Research Malcolm Mason David Montgomery The Institute of Cancer Institute, Durham Cardiff University, UK Pfizer Ltd, UK Research, London, UK University, UK Ricky Sharma Diana Tait Gray Institute for The Royal Marsden Owen Sansom Radiation Oncology NHS Foundation Trust Cancer Research UK Matt Seymour & Biology and Oxford and Dean, The Royal Beatson Institute, NIHR Cancer Research University Hospitals College of Radiologists, Glasgow, UK Network, Leeds, UK NHS Trust, Oxford, UK London, UK Josef Vormoor Katherine Vallis Northern Institute Alastair M Thompson Gray Institute for for Cancer Research, Dundee
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