SARS-Cov-2 Report 6 April 2021 Contents

José Luis Pires SARS-CoV-2 Report 6 April 2021 Contents

SARS-Cov-2 ➢ Vaccines and Products to treat COVID-19 with EUA in the United States ➢ Confirmed cases by Country ➢ Deaths by Country ➢ Total confirmed Covid-19 cases and deaths per million people ➢ Daily new confirmed Covid-19 cases and deaths per million people ➢ Number of COVID-19 cases reported weekly by WHO region ➢ Portugal ▪ Cases, Deaths and Projections – per week ➢ Ireland ▪ Cases, Deaths and Projections – per week ➢ New Jersey/US ▪ Cases, Deaths and Projections – per week ➢ Recent News

The Global Vaccination Campaign – sorted by Doses Administered More than 673 million doses have been administered across 155 countries, according to data collected by Bloomberg. The latest rate was roughly 16.2 million doses a day.

The Global Vaccination Campaign – sorted by Doses per % of people More than 673 million doses have been administered across 155 countries, according to data collected by Bloomberg. The latest rate was roughly 16.2 million doses a day.

Source: IHME - COVID-19 Results Briefing – 1 April 2021

US 30,785,390 Brazil 13,013,601 India 12,686,049 France 4,893,971 Russia 4,538,101 UK 4,376,629 Italy 3,678,944 Turkey 3,529,601 Spain 3,311,325 Germany 2,904,228 Argentina 2,407,159 Netherlands 1,329,560 Canada 1,017,130 Belgium 902,964 Israel 834,822 Portugal 823,494 6 Apr 30 Mar 23 Mar 16 Mar 9 Mar 2 Mar 23 Feb 16 Feb 9 Feb 2 Feb Sweden 813,191 Philippines 803,398 2021 2021 2021 2021 2021 2021 2021 2021 2021 2021 Hungary 689,853 Switzerland 605,342 Global Cases 131,832,701 127,664,084 123,716,810 120,246,451 117,177,827 114,480,829 111,757,691 109,162,197 106,512,038 103,435,830 Austria 560,972 Morocco 498,329 Global Japan 486,852 74,852,376 72,419,348 70,177,633 68,200,139 66,386,622 64,685,976 63,055,216 61,368,374 59,443,306 57,356,033 Malaysia 352,029 Recovery Croatia 280,164 Greece 277,277 Global Deaths 2,861,123 2,792,268 2,724,305 2,661,194 2,600,852 2,539,926 2,475,283 2,408,635 2,326,568 2,238,785 Ireland 238,466 Denmark 234,489 Lithuania 220,900 Fatality Rate 2.17% 2.19% 2.20% 2.21% 2.22% 2.22% 2.21% 2.21% 2.18% 2.16% Slovenia 220,425 Estonia 109,781 Korea 106,230 China 101,901 Norway 99,249 Last Updated at 6 April 2021, 8:20 AM Finland 79,737 Luxembo… 62,105 Singapore 60,495 by the Center for Systems Science and Engineering Thailand 29,571 at Johns Hopkins University https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 Australia : : 29,365 Iceland 6,225

Source 0 5,000,000April 2021 10,000,000 15,000,000 20,000,000 25,000,000Confidential Hovione © 202130,000,000 8 35,000,000 Coronavirus (SARS-CoV-2 / Covid-19) – Deaths by Country Note: Selected Countries, sorted by # of cases

600,000 555,613

500,000

400,000

332,752

300,000

Last Updated at 6 April 2021, 8:20 AM

by the Center for Systems Science and Engineering 200,000

111,326 at Johns Hopkins University

165,547 99,049

127,106 75,783 97,005 56,471 100,000

77,136 23,083

13,435

10,377

8,857

6,253 6,083 32,456 23,202 21,928 16,801 16,88513,498 9,482 9,229 1,295 8,4534,7182,4313,6234,082 950 1,7524,841 676 846 750 30 95 909 29 0

Source: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

Daily infections vs mortality per million

2021

4 APR APR 4 28 MAR 2021 MAR 28

(7-day average)

955839e06441

aeb3

11ea

48f8

- https://www.ft.com/content/a26fbf7e

Europe

Source: WHO

Africa Western Pacific South-East Asia

DAILY INFECTIONS PROJECTED IN 5 Apr 2021 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr 159 infections

Projected: 463

556

523

365

327

107

103

3 3

2 2 2 0

APRIL MAY JUNE JULY

Projection Daily Infections

For 1 July 2021

1 April Projection: 2

April 2021 Confidential Hovione © 2021 18 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Daily Deaths Projections in Portugal

5 Apr 2021 6 deaths DAILY DEATHS PROJECTED IN Projected: 7 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr

11 9 8 6

3 3 3 2 2 1 0 0 0 0 0 0 0 0 0

APRIL MAY JUNE JULY

Projection Daily Deaths

For 1 July 2021

1 April Projection: 0

April 2021 Confidential Hovione © 2021 19 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Total Deaths Projections in Portugal

5 Apr 2021 16,885 deaths TOTAL DEATHS PROJECTED IN Projected: 16,891

6 Mar 11 Mar 17 Mar 25 Mar 1 Apr

17146

17143

17111

17074

17071

17055

17052

17036

17024

17022

17017

17000

16923

16908

16906

16886

16876

16874 16789

APRIL MAY JUNE JULY

Projection Total Deaths

For 1 July 2021

1 April Projection: 17,055

April 2021 Confidential Hovione © 2021 20 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Coronavirus (SARS-CoV-2 / COVID 19) – Portugal – New cases per week

Total Cases in Portugal: 823,494 86,389

2021.04.05 84,326

66,112

56,435

44,898

39,082

37,977

34,983

34,041

32,681

27,675

26,270

25,655

25,377

20,452

20,342

18,775

13,247

11,769

7,513

7,037

5,547

5,532

5,316

5,307

5,027

4,594

4,362

4,163

3,725

3,621

3,467

3,273

2,928

2,877

2,615

2,513

2,490

2,443

2,299

2,251

2,193

2,171

2,124

1,997

1,877

1,609

1,587

1,528

1,495

1,455

1,434

1,355

1,299

1,205

215 30

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Average # of Patients stable in the Hospital per week Average # of Patients in the ICU per week

6561

6520 874

Total Patients in the Hospital: 536 Total Patients in the ICU: 112 839

5628 801

2021.04.05 5531 2021.04.05

701

699

4391

611

3922

546

526

522

518

507 507

493

490

3405

3297

3249

3224

458

3121

3056

2930

2906

404

2785

395

2638

2388

335

282

267

1867

1730

245

226

217

199

197

194

1356

1242

1171

1141

162

1105

154

980 140

926

130

128

883

848

828

114

783

110

104

695

692

671

591

585

549

512

497

488

484

462

441

430

428

422

411

409 58

394

375

351

344

327

325

304

139

10 0

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Active Cases: 25,966 Recoveries: 780,643 761,788 780,643 720,235 2021.04.05 668,854

534,384

394,065 338,668 280,038 220,877 179,180 125,066 125,861 102,794 81,771 88,854 60,026 75,008 67,805 74,989 68,370 42,104 44,362 48,937 36,08555,081 36,031 14,315 18,784 25,482 25,966

Active Cases Recovery Cases

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Total Deaths: 16,885

2021.04.05

2,013

1,676

1,608

1,163

1,058

685

641

596

575

536

530

516

499

485 485

355

352

228

223

210

209

189

176

144

140

135

105

101

69 69

21 21

18 18

0 0

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Portugal – Fatality Rate

4.34%

4.18%

4.13%

4.03%

3.74%

3.55%

3.40%

3.29%

3.25%

3.14%

2.90%

2.61%

2.32%

2.15%

2.05% 2.05%

2.03%

1.96%

1.76%

1.71%

1.66%

1.62%

1.53%

1.52% 0.22%

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

New Cases per 100,000 population

2,206

2,038 1,541 1,453 Moderate Risk

High Risk 1,059

Very High Risk

705

674 622

584 Extremely High Risk

520

513

480

470

454

341

335

222

149

112

79 63

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

New Cases per 100,000 population

2,123

1,965 1,451

1,404 Moderate Risk

High Risk 1,039

Very High Risk

721

653 644

625 Extremely High Risk

576

556

530

518

509

442

388

229

145

115

89 85

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Total Cases in Lisbon and Tagus Valley: 312,220

2021.04.05

43,040

34,934

25,668

22,868

19,875

11,343

10,526

9,524

8,916

8,701

8,579

7,873

7,630

7,537

7,387

6,453

5,811

5,420

4,271

3,292

2,897

2,624

2,616

2,272

2,242

2,084

1,990

1,934

1,931

1,775

1,769

1,755

1,719

1,704

1,650

1,426

1,277

1,243

1,195

1,188

1,187

1,179

1,155

1,031 1,031

993

944

937

875

821 822

787

659

516

418

110 5

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

100000 100%

92% 90000 86,389 90% 88%88% 84,326

80000 80% 80% 79%79%79% 78%78% 75% 70000 66,112 70% 68% 67% 65% 60000 56,435 60% 57% 55% 52% 50000 51% 52% 51% 51%52% 50% 49% 44,898 49% 47%47%47% 47% 43,040 47% 39,082 42% 40000 39% 37,977 40% 41%41% 40% 40% 34,983 34,041 39%34,934 39% 32,68135%35% 32% 31% 32% 27,675 32% 30000 30% 25,65529% 26,27030%30% 25,668 30% 29% 27% 25,377 27% 26% 22,868 25%23% 24% 20,452 20,342 18,775 19,875 20000 22% 20% 17% 18%18% 13,247 11,343 10,52611,769 8,9169,5248,701 7,513 8,579 7,5377,8737,630 7,037 10000 5,3165,307 5,0275,547 5,4207,387 6,453 5,811 5,532 10% 4,362 3,6213,467 3,7254,594 4,271 3,292 4,1633,273 1,6092,299 1,5871,8771,7192,1931,9311,9971,7552,4431,9342,5131,9902,2511,7752,6152,0842,1241,6501,528 2,1712,4901,7692,2722,6242,6162,897 2,2421,704 2,8772,928 305 2151101,355418 9441,426937 6591,0315161,1951,4559931,188 1,1871,2998751,2057871,4348211,4958221,0311,179 1,2771,1551,243 0 0%

Portugal LVT %

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

From: 27 Dec 2020 To: 28 Mar 2021

8 March 15 March 22 March 29 March 5 April

5 April 2021

Loures 63

Lisbon 85

2.5

1.5

R(t) 1.0 1

0.5 5 April

Source: SNS - http://www.insa.min-saude.pt/category/areasApril 2021 -de-atuacao/epidemiologia/covid-19-curva-epidemica-e-parametros-de-transmissibilidade/ Confidential Hovione © 2021 33 Transmission Rate - R(t) in Lisbon and Tagus Valley

2.5

1.5

R(t) 1.0 1

0.5 28 Mar

December 2020 March 2021

Source: Banco de Portugal

DAILY INFECTIONS PROJECTED IN 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr 5 Apr 2021 320 infections

496 Projected: 571

403

393

247

186

136

2 2 1

APRIL MAY JUNE JULY

Projection Daily Infections

For 1 July 2021

1 April Projection: 6

April 2021 Confidential Hovione © 2021 37 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Daily Deaths Projections in Ireland

5 Apr 2021 DAILY DEATHS PROJECTED IN 0 deaths 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr Projected: 11

13 9 9 8 4 5 3 2 0 0 1 1 1 0 0 0 0 0

APRIL MAY JUNE JULY

Projection Daily Deaths

For 1 July 2021

1 April Projection: 0

April 2021 Confidential Hovione © 2021 38 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Total Deaths Projections in Ireland

5 Apr 2021 4,718 deaths TOTAL DEATHS PROJECTED IN Projected: 4,747

6 Mar 11 Mar 17 Mar 25 Mar 1 Apr

5472

5468

5438

5150

5133

5109

5105

5098

5049

5017

5000

4988

4913

4888

4886

4864

4786

4697 4679

APRIL MAY JUNE JULY

Projection Total Deaths

For 1 July 2021

1 April Projection: 5,150

April 2021 Confidential Hovione © 2021 39 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Coronavirus (SARS-CoV-2 / COVID 19) ) – Ireland - New cases per week

Total Cases in Ireland: 238,466 45,770

2021.04.05

25,212

15,759

13,499

9,016

7,495

7,194

7,170

6,622

6,044

5,546

4,940

4,574

4,510

4,033

4,011

3,992

3,864

3,660

3,638

3,544

3,500

3,381

3,071

3,043

2,622

2,613

2,379

2,244

2,084

2,050

1,982 1,984

1,830

1,709

1,490

1,314

1,116

921

737

732

707

557

550

527

379

286

249

148

143

127

122

112

65 20

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

Coronavirus (SARS-CoV-2 / COVID 19) ) – Cork - New cases per week 4,583 Total Cases in Cork: 21,876

2021.04.03

2,407

1,392

974

870

832

821

799

556

444

391

380

320

305

296

238

235

209

203

202

190

184

170

160

145

137

135

119

114

107

104

12 12

9 9 9

5 5

0 0 0 0

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

DAILY INFECTIONS PROJECTED IN 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr 5 Apr 2021 2,457 infections

5883 Projected: 4,593

5612

4308

2506

2270

1975

1373

1329

791

664

560

325

323

322

310

177

163

156 31

APRIL MAY JUNE JULY

Projection Daily Infections

For 1 July 2021

1 April Projection: 31

April 2021 Confidential Hovione © 2021 43 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Daily Deaths Projections in New Jersey

DAILY DEATHS PROJECTED IN 5 Apr 2021 6 Mar 11 Mar 17 Mar 25 Mar 1 Apr 12 deaths 56 Projected: 37 51 51 45 46 39 37 32 22 16 17 11 10 6 6 7 3 3 1

APRIL MAY JUNE JULY

Projection Daily Deaths

For 1 July 2021

1 April Projection: 1

April 2021 Confidential Hovione © 2021 44 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend Covid-19 Total Deaths Projections in New Jersey

5 Apr 2021 TOTAL DEATHS PROJECTED IN 22,081 deaths

6 Mar 11 Mar 17 Mar 25 Mar 1 Apr Projected: 24,743

27779

27737

27490

27370

26936

26767

26614

26543

26481

26214

26140

25879

25763

25765

25452

24907

24833

24702 24692

APRIL MAY JUNE JULY

Projection Total Deaths

For 1 July 2021

1 April Projection: 26,614

April 2021 Confidential Hovione © 2021 45 Source: Institute for Health Metrics and Evaluation / University of Washington - https://covid19.healthdata.org/portugal?view=daily-deaths&tab=trend U.S. Vaccination Distribution in the U.S. is directed by the federal government. Pfizer and BioNTech’s vaccine, as well as Moderna’s shot both require two doses taken several weeks apart. J&J’s inoculation requires just a single dose

Drugmakers have promised to deliver enough shots to fully vaccinate 130 million Americans by the end of March and 300 million people by the end of May. That’s more than enough for every adult, and clinical studies in children are underway.

Source: Bloomberg

Coronavirus (SARS-CoV-2 / COVID 19) ) – New Jersey - New cases per week 37,043

Total Cases in New Jersey: 817,464 36,762 33,902

2021.04.05 33,142

31,942

30,821

29,905

28,629

28,539

28,107

26,733

25,534

24,783

24,679

24,664

24,483

24,278

23,737

22,939

21,470

21,112

20,186

19,214

18,979

17,706

17,549

14,966

11,788

11,472

11,161

8,455

7,820

7,802

6,385

6,291

5,426

4,654

3,786

3,719

3,128

2,987

2,717

2,682

2,580

2,576

2,447

2,423

2,261

2,220

2,117

2,040

2,039

1,896

1,816

1,516

92 6

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

• Novavax has initiated crossover arms in two of its ongoing trials of NVX-CoV2373, the company’s Covid-19 vaccine candidate. Crossover ensures the administration of the vaccine to all participants in the trials taking place in Novavax’s Phase IIb trial in South Africa and Phase III trial in the UK. The company is also planning to include paediatric and adolescent arms in the trial, which is expected to begin in the second quarter.

• Coronavirus vaccines developed by China’s Sinovac Biotech Ltd. and Sinopharm Group Co. appeared safe and effective in an interim analysis, though the World Health Organization wants more details on the elderly and infirm. The companies applied for the WHO’s emergency-use listing and the group’s Strategic Advisory Group of Experts on Immunization reviewed the information gathered thus far, according to details reported by Agence France Presse and confirmed by a person familiar with the matter.

• A manufacturing error at a Baltimore plant affected 15 million doses worth of an ingredient for Johnson & Johnson’s vaccine, according to two sources familiar with the matter, but the company downplayed the situation and said it met its most recent vaccine delivery target. In a statement, J&J said a batch of drug substance failed its quality test. J&J said it beat its March delivery target, providing the US government more than 20 million doses, and that it expects to deliver another 24 million by the end of April.

• Pfizer Inc. said its vaccine was 100% effective in a final-stage trial in kids ages 12 to 15, a finding that could pave the way for shots for teens and pre-teens before the next school year. The vaccine is already authorized in the U.S. for people ages 16 and up. Pfizer and its partner BioNTech SE said they planned to submit the data to regulators in the US and Europe as soon as possible, seeking to amend their vaccine authorizations to include the younger age group.

• The European Union will have delivered 107 million vaccines by the end of this week, reaching the bloc’s targeted goal for the first three months of the year. The milestone was confirmed by European Commission spokesperson Dana Spinant. It was a revised goal that had to take into account multiple delays in the deliveries from AstraZeneca Plc.

• Europe’s drug regulator is investigating 62 cases worldwide of a rare blood clotting condition which has prompted some countries to limit the use of AstraZeneca’s Covid vaccine, its chief said in a briefing.

• BioNTech and Pfizer raised this year’s production target for their vaccine to as many as 2.5 billion doses, with the German biotech’s chief executive officer predicting a version of the shot that can be stored in refrigerators will be ready within months. The new target represents an increase of about one quarter from an earlier estimate. BioNTech said it expects 9.8 billion euros ($11.5 billion) in revenue from the supply contracts signed already, which amount to 1.4 billion doses. Revenue expectations include milestone payments from BioNTech’s partners and will rise as more orders are signed, the company said.

• Google will donate $1 million to help New York City reach its goal of 5 million vaccinations by the end of June, Mayor Bill de Blasio said. The donation includes advertising grants to run ads on where, when and how to get a vaccine, as well as a grant from the tech giant’s philanthropic arm to set up an inoculation center at the Fulton Houses public-housing complex in Chelsea, near Google’s main New York office. De Blasio said Tuesday that the city is approaching 4 million vaccine doses.

• Covid-19 vaccines from Pfizer Inc. and Moderna Inc. effectively prevented coronavirus infections, not just illness, with substantial protection evident two weeks after the first dose, government researchers said. Two doses of the vaccines provide as much as 90% protection against infection, according to data from US Centers for Disease Control and Prevention study published Monday. Earlier clinical trials had established that the shots also prevent illness, hospitalizations, and deaths.

• GSK and Vir Biotechnology have submitted an application for Emergency Use Authorization (EUA) with the US Food and Drug Administration (FDA) for use of investigational monoclonal antibody VIR-7831 (GSK4182136) in the treatment of adults and adolescents with mild symptoms of Covid-19.

• The European Medicines Agency (EMA) has advised EU member states to use Celltrion Group’s regdanvimab (CT-959) for patients with severe Covid-19, based on a positive opinion given by the agency’s Committee for Medicinal Products for Human Use (CHMP). Regdanvimab has demonstrated an ability to neutralise the SARS-CoV-2 wild-type virus, as well as prominent mutations such as the UK variant (B.1.17).

• The EU will block AstraZeneca exports if the company fails to deliver the doses bought by the region on time, according to Thierry Breton, the EU commissioner in charge of fixing the bloc’s vaccination drive. AstraZeneca has met about 30% of its commitment to deliver 70 million doses to the EU in the second quarter, Breton said on RTL radio Sunday. “As long as AstraZeneca doesn’t make good on its obligations, everything that’s produced on European soil is distributed to Europeans,” he said. The head of the EU’s vaccine taskforce said he hoped Europe would have a summer tourist season “comparable to last year”, supported by the bloc’s vaccine rollout. A new poll shows that 68% of Britons have not booked any summer holiday this year.

• European Union officials will probably block future exports of AstraZeneca Plc’s Covid-19 vaccine to the UK according to an EU official, deepening a post-Brexit conflict that has festered as Europe seeks to get its vaccination drive on track. Any AstraZeneca vaccines and components produced in the EU are set to be reserved for local use and the EU isn’t responsible for helping the company meet commitments to Britain, said the official, who asked not to be named discussing internal EU deliberations. UK Defense Secretary Ben Wallace earlier Sunday called on the European Commission to honor Covid-19 vaccine contracts.

• New Covid-19 vaccines, including ones that don’t require needles and can be stored at room temperature, may be ready for use later this year or next year, the World Health Organization’s top scientist said. Six-to-eight new immunizations may complete clinical studies and undergo regulatory review by the end of the year, Soumya Swaminathan, the Geneva-based agency’s chief scientist, said in an interview Saturday.

• Ireland reported the most new cases in nearly a month, threatening government plans to ease restrictions. There were 769 newly confirmed cases with two deaths, the health ministry said. Ireland has been effectively locked down since Christmas, and the government had planned to ease limits on travel and construction early next month. Cases have started to increase in recent days despite the current restrictions, while hospitalizations are increasing again too.

• The UK Medicines and Healthcare products Regulatory Authority (MHRA) and European Medicines Agency (EMA) have confirmed the safe use of AstraZeneca’s Covid-19 vaccine, reiterating that the vaccine’s benefits outweigh the risks. While a detailed review on any link between the vaccine and blood clots is currently underway, the EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) concluded that AstraZeneca’s vaccine did not raise the overall risk of thromboembolic events.

• Moderna has started dosing the first participants in a Phase II/III clinical trial called the KidCOVE study, of mRNA-1273, the company’s Covid-19 vaccine. The KidCOVE study is being conducted in children aged from six months to 12 years, and is being conducted in collaboration with the National Institutes of Health (NIH) and US Department of Health and Human Services (HHS).

• Moderna has dosed the first patients in a Phase I study of mRNA-1283, the company’s next-generation Covid-19 vaccine candidate. mRNA-1283 is a potential refrigerator-stable vaccine that is designed to allow easy distribution and administration across settings, especially in developing countries.

• The Janssen Covid-19 vaccine has already been approved by European Union authorities, and can be administered among patients aged 18 years and older, including those aged 65 years and older, and patients suffering with other illnesses. Janssen’s vaccine will be the fourth Covid-19 vaccine to launch in the French market.

• The European Medicines Agency (EMA) is currently investigating whether any of the three approved Covid-19 vaccines in the bloc may be linked to a blood clotting deficiency that can cause internal bleeding. According to the EMA, several instances of immune thrombocytopenia, a shortage of blood platelets that can lead to bruising and bleeding, have been identified in vaccine safety monitoring process. The agency is monitoring the reports of individuals who have received the Pfizer/BioNTech, AstraZeneca and Moderna vaccines.

• Israel's Ministry of Health, Pfizer and BioNTech announced that real-world evidence demonstrates lower incidence of Covid-19 disease among individuals fully vaccinated with the Pfizer/BioNTech's Covid-19 vaccine (BNT162b2), highlighting the significant public health impact of Israel’s quick, nationwide immunisation programme. The latest analysis showed that two weeks after the second dose, the vaccine was 97% effective in preventing symptomatic disease, severe or critical disease, and death.

• Johnson & Johnson told the EU it was facing supply issues that may complicate plans to deliver 55 million doses of its Covid-19 vaccine to the bloc in the second quarter of the year, an EU official told Reuters.

• Sorrento Therapeutics announced major progress in developing COVISHIELD antibody combinations through a license agreement with researchers at the Icahn School of Medicine at Mount Sinai. The agreement allows for the collection of antibodies which have the SARS-CoV-2 virus neutralising properties developed by Mount Sinai. This follows on from the success of Sorrento’s intravenous STI-2020 (COVI-AMG) and its intranasal STI-2099 (COVIDROPS).

• Baxter International and Moderna have entered into an agreement for the former's Baxter BioPharma Solutions to provide fill and finish sterile manufacturing services, as well as supply packaging, for up to 90 million doses of the Moderna Covid-19 Vaccine in 2021 in the US. The vaccine will be manufactured at the BioPharma Solutions facilities in Bloomington, Indiana.

• https://en.wikipedia.org/wiki/Timeline_of_the_2019%E2%80%9320_Wuhan_coronavirus_outbreak • https://www.seattletimes.com/seattle-news/health/coronavirus-timeline-how-the-outbreak-unfolded/ • https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 • https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports • https://www.pharmaceutical-technology.com/news/coronavirus-a-timeline-of-how-the-deadly-outbreak-evolved/ • https://www.cphi-online.com/updated-covid19-pharma-tracker-news082415.html • https://www.dgs.pt/em-destaque.aspx

• José Luis Pires Business Intelligence Manager [email protected]