RAPGEF5 Antibody Cat. No.: 58-923
RAPGEF5 Antibody
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human
This RAPGEF5 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 529-555 amino acids from the C-terminal region of human RAPGEF5.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR 68 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
September 26, 2021 1 https://www.prosci-inc.com/rapgef5-antibody-58-923.html PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: RAPGEF5
Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, ALTERNATE NAMES: M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac, RAPGEF5, GFR, KIAA0277, MRGEF
ACCESSION NO.: Q92565
PROTEIN GI NO.: 32171396
GENE ID: 9771
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve BACKGROUND: as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).
REFERENCES: 1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
2) Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
3) Hwang, S.J., et al. BMC Med. Genet.SUPPL 1, S10 (2007) :
4) Rebhun, J.F., et al. J. Biol. Chem. 275(45):34901-34908(2000)
ANTIBODIES FOR RESEARCH USE ONLY.
For additional information, visit ProSci's Terms & Conditions Page.
September 26, 2021 2 https://www.prosci-inc.com/rapgef5-antibody-58-923.html