RAPGEF5 Antibody Cat. No.: 58-923

RAPGEF5 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This RAPGEF5 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 529-555 amino acids from the C-terminal region of human RAPGEF5.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 68 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

September 26, 2021 1 https://www.prosci-inc.com/rapgef5-antibody-58-923.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: RAPGEF5

Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, ALTERNATE NAMES: M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac, RAPGEF5, GFR, KIAA0277, MRGEF

ACCESSION NO.: Q92565

PROTEIN GI NO.: 32171396

GENE ID: 9771

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Members of the RAS (see HRAS; MIM 190020) subfamily of function in as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve BACKGROUND: as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).

REFERENCES: 1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

2) Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)

3) Hwang, S.J., et al. BMC Med. Genet.SUPPL 1, S10 (2007) :

4) Rebhun, J.F., et al. J. Biol. Chem. 275(45):34901-34908(2000)

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 26, 2021 2 https://www.prosci-inc.com/rapgef5-antibody-58-923.html