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Program 15 Day of Clinical Research Universität Zürich Medizinische Fakultät Zentrum für Klinische Forschung (ZKF) / Center for Clinical Research (CCR) Clinical Trials Center (CTC) Program 15th Day of Clinical Research Georg-Friedrich-Götz-Preisverleihung 2016 Zurich, March 31, 2016 Assoziierte Kliniken Kinderspital Zürich Universitätsklinik Balgrist Kinder- und Jugendpsychiatrischer Dienst des Kantons Zürich Psychiatrische Universitätsklinik Structure of the Center for Clinical Table of contents Research/ Clinical Trials Center Kuratorium Program 1 - 3 Prof. Dr. J-M. Fritschy (Stv. Dekan, ex officio) Prof. Dr. Ch. Hock (Prorektor, ex officio) Prof. Dr. J. Hodler List of Abstracts 4 - 18 Prof. Dr. T. Lüscher Prof. Dr. P.-A. Clavien Prof. Dr. M. Pruschy Abstracts 19 - 196 Prof. Dr. S. Gay Prof. Dr. R. Nitsch lic. oec. HSG R. Ziegler Prof. Dr. B. Stieger Prof. Dr. G. Zünd (Managing Director) Direktorium Prof. Dr. M. Weller Prof. Dr. A. von Eckardstein (Co-Direktor) Prof. Dr. A. Aguzzi (Co-Direktor) Prof. Dr. G. A. Kullak-Ublick Prof. Dr. H. Moch Prof. Dr. G. Spinas Prof. Dr. G. Zünd (Managing Director) PD Dr. Paolo Cinelli PD Dr. Mira Katan-Kahles Geschäftsstelle ZKF Robin Schneider, MBA Geschäftsführer Clinical Trials Center PD Dr. G. Senti Leitende Ärztin Clinical Trials Center Biologisches Zentrallabor Dr. Hugo Battaglia Leiter Biologisches Zentrallabor Forschungsgruppenleiterkonferenz PD Dr. Paolo Cinelli PD Dr. Mira Katan-Kahles Scientific Research Group Leaders of the University Hospitals of Zurich (University Hospital, Children’s Hospital, Balgrist University Clinic, Psychiatric University Hospital) and related institutions of the Faculty of Medicine Bild Vorderseite: PD Dr. med. Paolo Cinelli & Nico Wick-Mazzarda, UniversitätsSpital Zürich Programm Donnerstag, 31. März 2016 Grosser Hörsaal Ost 08.15 Eröffnung Prof. Dr. Gregor Zünd Managing Director ZKF, Direktor Forschung und Lehre, UniversitätsSpital Zürich 08.20 Begrüssung Rita Ziegler, lic. oec. HSG Vorsitzende der Spitaldirektion 08.25 Begrüssung Prof. Dr. Rainer Weber Dekan der Medizinischen Fakultät der Universität Zürich Session 1: Cardiovascular/Metabolics/Endocrinology Chairpersons: Prof. Dr. Michele Genoni, Prof. Dr. Matthias Baumgartner 08.35 Wissenschaftliches Hauptreferat “Vascular “glue” to cure sepsis?” PD Dr. med. Reto Schüpbach, Leitender Arzt, Intensivmedizin, UniversitätsSpital Zürich 08.55 A novel mouse model of methylmalonic aciduria circumvents neonatal lethality P. Forny, M. Mustedanagic, P. Burda, T. Hornemann, M. Baumgartner 09.05 Impaired glucose tolerance in mice with β-cell specific deletion of Pkbα M. Dietrich, R. Zuellig, M. Niessen, G. Spinas, O. Tschopp 09.15 Obstructive Sleep Apnea in Ehlers-Danlos Syndrome. A prospective case-control study T. Gaisl, C. Giunta, K. Sutherland, D. Bratton, C. Schlatzer, N. Sievi, D. Franzen, P. Cistulli, M. Rohrbach, M. Kohler 09.25 Mid-regional pro-adrenomedullin (MR-proADM) is an independent predictor of post stroke mortality C. Huber, J. Schneider, B. Mueller, M. Christ-Crain, M. Katan 09.35 Coffee Break Session 2: Hematology/Oncology Chairpersons: Prof. Dr. Markus Manz, Prof. Dr. Matthias Guckenberger 09.50 Wissenschaftliches Hauptreferat “The landscape for early drug development in oncology: pitfalls and chances “ PD Dr. med. Roger von Moos, Leitender Arzt, Klinik & Poliklinik für Onkologie, UniversitätsSpital Zürich 10.10 Aging-associated intrinsic and extrinsic factors control hematopoietic stem cell behavior L. Kovtonyuk, R. Ramin, H. Takizawa, M. Manz 10.20 Blocking of the epigenetic repressor Ezh2 controls tumor escape upon IL-2cx immunotherapy N. Arenas-Ramirez, D. Zingg, R. Rosalia, A. Antunes, J. Haeusel, L. Sommer, O. Boyman 10.30 Generation of a conditional transgenic mouse model of immunoglobulin light chain (AL) amyloidosis M. Nuvolone, S. Sorce, P. Pelczar, E. Rushing, F. Lavatelli, G. Palladini, G. Merlini, A. Aguzzi 1 10.40 The NKG2D system mediates anti-tumor effects of chemotherapy and radiotherapy against glioblastoma T. Weiss, H. Schneider, M. Silginer, A. Steinle, M. Pruschy, M. Weller, P. Roth Session 3: Stem Cell Research, Regenerative Medicine and Advanced Technologies Chairpersons: Prof. Dr. Dr. Simon Hoerstrup, PD Dr. Oliver Gämperli 10.55 Wissenschaftliches Hauptreferat “Translating basic research into clincially applicable skin” Dr. Thomas Biedermann, PhD, Post Doc, Kinderspital Zürich, The Tissue Biology Research Unit 11.15 Impact of solubilized muscle-specific urethral extracellular matrix on skeletal muscle differentiation for sphincter reconstruction I. Simões, D. Keller, P. Vale, J. Cabral, C. Da Silva, P. Baptista, T. Sulser, D. Eberli 11.25 The Consent, Contact, and Community framework for Patient Reported Outcomes – Enhancing Apple's ResearchKit for iPhone Apps with FHIR P. Pfiffner, I. Pinyol, M. Natter, K. Mandl 11.35 Maintenance of human hematopoiesis in in vivo engineered bone organs K. Fritsch, P. Bourgine, P. Bourgine, S. Pigeot, T. Schröder, I. Martin, H. Takizawa, H. Takizawa, M. Manz 11.45 Drug Delivery device to support tendon rupture repair: biomechanical outcome of in vivo rabbit Achilles tendon full laceration experiments three weeks post-surgery O. Evrova, G. Meier Bürgisser, M. Calcagni, C. Scalera, E. Bachmann, J. Snedeker, P. Giovanoli, V. Vogel, J. Buschmann 11.55 Lunch/Poster viewing Session 4: Infection/Immunity/Inflammation Chairpersons: Prof. Dr. Janine Reichenbach, Prof. Dr. Roberto Speck 13.50 Wissenschaftliches Hauptreferat “Cytokines: From Bench to Clinic“ Prof. Dr. med. Onur Boyman, Klinikdirektor, Klinik für Immunologie, UniversitätsSpital Zürich 14.10 Stimulation of cytotoxic T cells by photosensitization-based Vaccination S. Freiberger, E. Varypataki, M. Hakerud, T. Kündig, P. Johansen 14.20 Type II IL-4 receptor expression on neutrophils antagonizes their expansion and migration during infection and inflammation J. Woytschak, N. Keller, D. Impellizzieri, R. Thompson, T. Wynn, A. Zinkernagel, O. Boyman 14.30 1-Deoxy-sphingolipids, novel biomarkers of diabetes, are cytotoxic for exocrine pancreatic cells R. Chen, T. Hornemann, W. Yu, S. Camargo, R. Graf, S. Sonda 14.40 The impact of preconditioning by Sevoflurane after experimental mouse lung transplantation Y. Yamada, I. Laube, J. Jang, J. Bonvini, I. Inci, B. Beck Schimmer, W. Weder, W. Jungraithmayr 14.50 Coffee Break Session 5: Neurosciences/Pharmacology Chairpersons: Prof. Dr. Gerd-Achim Kullak-Ublick, Prof. Dr. Michael Weller 15.05 Wissenschaftliches Hauptreferat “Sleep-wake disturbances following traumatic brain injury” Prof. Dr. med. Christian Baumann, Leitender Arzt, Klinik für Neurologie, UniversitätsSpital Zürich 2 15.25 The role of brain pericytes in the regulation of leukocyte trafficking and immune response under homeostatic and pathological conditions O. Török, B. Schreiner, A. Keller 15.35 A neuroprotective role for microglia in prion diseases C. Zhu, U. Herrmann, J. Falsig, I. Abakumova, M. Nuvolone, P. Schwarz, E. Rushing, A. Aguzzi 15.45 Inhibition of group I metabotropic glutamate receptors (mGluR1 and mGluR5) protects against prion-induced toxicity D. Goniotaki, L. Lakkaraju, A. Shrivastava, P. Bakirci, S. Sorce, P. Pelczar, F. Gasparini, A. Triller, A. Aguzzi 15.55 Complete resection of contrast enhancing tumor volume is associated with improved survival in recurrent glioblastoma – results from the DIRECTOR trial H. Wirsching, J. Tonn, G. Tabatabai, C. Senft, P. Hau, M. Sabel, U. Herrlinger, R. Ketter, U. Schlegel, C. Marosi, G. Reifenberger, W. Wick, M. Weller, B. Suchorska 16.05 Coffee Break Session 6: Klinische Forschungsschwerpunkte KFSP 16.20 Präsentation Small RNA’s Prof. Dr. Adriano Aguzzi, Institutsdirektor, Institut für Neuropathologie, UniversitätsSpital Zürich 16.40 Präsentation Molecular Imaging Network Prof. Dr. phil. Bruno Weber, Lehrstuhl für Multimodale experimentelle Bildgebung, Institut für Pharmakologie und Toxikologie, Universität Zürich 17.00 Präsentation Zurich Primary HIV Infection Study Dr. med. Dominique Braun, Oberarzt, Klinik für Infektionskrankheiten und Spitalhygiene, UniversitätsSpital Zürich 17.25 Posterpreis 17.35 Verleihung Georg Friedrich Götz-Preis 2016 18.50 Apéro 3 Cardiovascular Diseases/Metabolics/Endocrinology Basic Research 3447 G. Zhibo, G. Ting, H. Christian, K. Gerd Farnesoid X receptor protects against kidney injury in uninephrectomized obese mice 3478 C. Schuoler, T. Haider, C. Leuenberger, L. Ostergaard, M. Gassmann, M. Kohler, L. Huber, M. Brock Aquaporin 1 and Vascular Remodeling: a Novel Player in Hypoxia-Induced Pulmonary Hypertension 3519 M. Dietrich, R. Zuellig, M. Niessen, G. Spinas, O. Tschopp Impaired glucose tolerance in mice with β-cell specific deletion of Pkbα 3533 L. Ahnen, S. Sanchez Imaging Cerebral ischemia in preterm infants with sound and light 3584 L. Rigassi, E. Unterleutner, F. Barchiesi, B. Imthurn, R. Dubey Role of microRNA-193a in mediating the protective action of Estradiol in vascular cells 3596 P. Forny, M. Mustedanagic, P. Burda, T. Hornemann, M. Baumgartner A novel mouse model of methylmalonic aciduria circumvents neonatal lethality Clinical Trials 3419 D. Benz, C. Gräni, F. Mikulicic, J. Vontobel, T. Fuchs, R. Buechel, P. Kaufmann From Low-dose to Too-low-dose? Evaluating Two New Contrast Protocols for Coronary Computed Tomography Angiography on a Latest-generation 256-slice CT Scanner 3534 T. Gaisl, C. Giunta, K. Sutherland, D. Bratton, C. Schlatzer, N. Sievi, D. Franzen, P. Cistulli, M. Rohrbach, M. Kohler Obstructive Sleep Apnea in Ehlers-Danlos Syndrome. A prospective case-control study 3548 C. Huber, J. Schneider,
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