May 2017 53 www.temis.org news besançonTEMIS - burgundy-franche-comté -

Editorial

Watchmaking and The TEMIS Technology Park and its ecosystem continue to astonish with the wealth of projects that are being developed in it every day. It medical engineering comes as no surprise, then, that companies that are exceptionally dynamic are joining TEMIS. Know-how For example, we could look at Polycaptil and iXblue, which have recently decided to come to TEMIS. Their leading-edge know-how is recognised Made in Besançon not just domestically, but also internationally. Two areas with a high technology content particularly stand out, making Besançon and the wider region an exemplar of what needs to be done. Watchmaking first, with companies that perpetuate high standards in watchmaking and microtechnology by inventing the time- pieces of the future. In that, they are supported by all the resources for training and research available in Besançon, particularly the researchers of the FEMTO-ST laboratory and its Time-Fre- quency department. This June, as in the past, the 24 Hours of Time event will celebrate and highlight our strengths in the field. Medical engineering is another area where our companies and laboratories are leading the way. All the parties involved in TEMIS Santé, the University Hospital and its Centre for Clinical Investigation are doing sterling work for inno- vation in healthcare and the improvement of the care and comfort of patients. At its innovation day, the hospital put on display the latest technological advances achieved in Besançon in the fields of neurostimulation and assisted reproductive technology, to serve medicine in the future. TEMIS and the whole ecosystem of our region are attractive. At the first edition of Journées Granvelle Besançon held this year, top experts and leading groups came together to work on the subject of digital technology, to exploit and make the most of the strengths of our region. Let us keep that momentum going!

Jean-Louis Fousseret, Mayor of Besançon President of Temis and Grand Besançon

P 2-3 P 6-7 24 Hours of Time Biotherapy and technological in Besançon innovation Special watchmaking

24 Hours of Time in Besançon Time in all its dimensions

An annual event that celebrates not just watchmaking know-how, but also research in the field of Time-Frequency, the fourth 24 Hours of Time will be held on 3 and 4 June.

a promising event where 30,000 the work of watchmakers and providing valuable visitors are expected. assistance. Among the companies that could be U The event was founded in 2014 at the mentioned in this context are Percipio Robotics initiative of Bertrand Lefebvre, (automation of watchmaking) and Frec | n | sys. ” former director of Besançon, and adds Professor Bernard Dulmet. is organised jointly by the French Society for Microtechnology and Timekeeping (SFMC), Time is more than watchmaking France Bleu Besançon and the Bill agency. The 24 Hours of Time event is very aptly named. “As early as in the second year of 24 Hours of Because time is not just about watchmaking and Time, the need to bring in the world of research microtechnology aspects. An exhibition at the was felt. ENSMM and the FEMTO-ST Institute regional contemporary arts centre will query and its Time-Frequency department soon became the subjects of time and space, an atomic clock participants at the event and SFMC became its will be on display throughout the event and sponsor. ” explains Professor Bernard Dulmet of researchers will share their knowledge and passion the Time-Frequency Department of the Femto-ST for time in workshops open to the general public. Institute, also President of SFMC. “Watchmaking research is very focussed on industry, while time and frequency research Microtechnology and watchmaking covers other areas, such as astronomy. The work While the event bears the mark of watchmaking of the Time-Frequency Department of Femto-ST in all its facets, it cannot be likened to a mere is not limited to mechanical clocks, those adapted watchmaking fair. Because even though its to humans. For instance, we are also interested exhibitors include watchmakers and a watch in optical clocks that are very precise, because exchange is organised, this year over two days, they use high frequencies – and already develop the event also encompasses microtechnology atomic clocks – and can for instance be applied as a whole. in financial markets to arbitrate transaction Top to bottom: “Microtechnology, and particularly micro- agreements. ” explains Professor Bernard Dulmet. organising team of 24 Hours of Time: mechanical engineering, are areas of interest due Bernard Dulmet, to the contribution of the watchmaking heritage President of SFMC to microtechnology know-how in the region. ” Alexandre Tandin, clarifies Justine Martin, Project Manager at Director of France Bleu Besançon the Bill agency. Delphine Dannecker, “The link between microtechnology and Bill agency watchmaking may be obvious, but needs to be Organiser of 24 hours emphasised. The Applied Mechanical Engineering of Time Department of the Femto-ST Institute regularly collaborates with watchmakers. The efforts of companies from the Femto-ST laboratory and the TEMIS Technology Park are revolutionising

TEMIS news 2 high points Time-Frequency of the 2017 edition With seven main departments and a multidisciplinary team of 750, the FEMTO-ST Institute is among the largest engineering science research laboratories  Round table meeting on watchmaking in France. st in the early 21 century on Saturday 3 June One of its research units, the LNE-LTFB test laboratory, at 4 pm takes part in projects with a national and  Talk on the irruption of Ernest Lipmann international scope for scientific developments in the watchmaking landscape of Besançon in time and frequency. on Saturday 3 June at 2.30 pm World record holder for the measurement of time to 10-14 seconds, the department carries out research  Free guided tour lasting one hour on activities that have been recognised by the national the symbols of time, Saturday 3 June strategy for research and innovation. at 3 pm at the Time Museum  Watchmaking market hall with over 20 brands present  Free games and workshops for children and adults over the entire weekend key figures  New: Watch exchange throughout the weekend. Saturday 3 June (12 noon to Besançon 1,500 6 pm) and Sunday 4 June (10 am to 5 pm) at the Kursaal French capital direct jobs in luxury of watchmaking watchmaking in Besançon 5,000 Research and training, jobs in watchmaking 2,200 time to prepare the future and luxury goods jobs in watch- This year’s event will highlight training. in Besançon making in That is because it is indispensable to allow = 6% of the overall Franche-Comté the public, particularly young people, economy of Grand to discover the different trades involved Besançon in order to prepare for the future. 47 P2R Formations, the new watchmaking and establishments polishing training centre in Besançon, the 1,000 in Grand watchmaking high school in Morteau, the direct jobs in jewellery Besançon adult training organisation and many others and luxury jewellery will organise demonstrations and presentations in Besançon Source: Bill agency of the courses on offer. The Muchrono organisation of ENSMM will coordinate a watch movement creation workshop and present its carousel - a revolving device designed to make watches more accurate. SFMC Experiments involving time and light will also be presented by the Femto-ST The French Society for Microtechnology and laboratory and its doctoral students. Timekeeping (SFMC) was founded in Besançon in 1931. As a scholarly society and voluntary organisation, it was recognised to be in the public interest in 1959. 24 Hours of Time The aim of SFMC is to promote all things related to Date: 3 and 4 June 2017 24 Hours of Time the measurement of time. It also gives prizes and Place: Besançon Granvelle awards to young technicians, engineers, researchers Admission free of charge #24HDT and authors of works of high scientific value in the area of the metrology of time, frequencies and microtechnology. The organisation of conferences More information on the subject is also part of its duties. www.les24hdutemps.fr

3 Special watchmaking

More information www.humbert-droz.fr REPARALUX A NEW GENERATION Repair workshop recognised for its know-how and expertise in the most prestigious makes of watches, REPARALUX was OF WATCHMAKING founded in 1956 by Marcel Humbert Droz. In June 2016, to celebrate its 60th anniversary, the company is on its way created its own brand of watches, Humbert-Droz. Its ambition is to make small quantities of French watches for a reasonable The art of watchmaking in Besançon was at its price. Three watch models were released, the first one named zenith in the middle of the 19th century, collapsing HD1 as a reference to the initials of the founder. eventually due to the many major national With the exception of dials, the watches are made and assembled economic crises that occurred in the course of in the workshops of REPARALUX in Besançon, and can thus boast the 20th century. Forty years after the adventure that they are “Made in Besançon”. of LIP, many are those who dream of a revival of 100% French know-how in the near future. Close up of some young companies that combine talent and promise. An alliance between high design and engineering The new watchmaking brand Lornet, know-how à la française from Besançon, Phenomen, is shaking up the industry The brand was born in November 2016 and stands out because through the bold design it has of its ability to produce automatic mechanical watches that given its watches. Meyer and are developed, manufactured and assembled in France. Out Gamiette are fine-tuning their of the 158 parts in its timepieces, only three come from own movement and ought . The other components are made in Franche- to present their first model Comté and the movement is made in house. Even though by the end of the year. the brand is already exceptional because of its capacity to complete all its stages in France, the founder, Anthony Simao, would eventually like to achieve 100% French made status Contact: [email protected] and create his own works.

More information www.lornet-watches.com programme

Between traditional know-how and modernity As the last French maker of mechanical clock movements, 19–25 June/Paris Manufacture VUILLEMIN is leveraging its know-how for modernity by offering contemporary creations that comply with the art of SIAE (Le Bourget) watchmaking and the requirements for living heritage company approval. The 52nd edition of the international Now an indispensable player at events dedicated to the aerospace fair will be held in the Le Bourget representation of the industry, the “Manuf” is looking at exhibition centre from 19 to 25 June 2017. It international markets by exporting its collections all over the world. will bring together all the players in global industry around the latest technological More information innovations. www.manufacture-horloges-comtoises.com Burgundy-Franche-Comté and the Aeromicrotech cluster of the Microtechnology centre will be at Hall 4- Booth F57.

For more information: www.siae.fr Monumental The Observatory clockmaking and accurate Specialised in monumental 20–23 June/Geneva timekeeping clocks, Utinam is also a specialist of the reinvention The science observatory EPHJ EPMT SMT of watchmaking in of Besançon, which is the Franche-Comté, which is EPHJ brings together trades and companies custodian of the viper’s head hallmark, three centuries old! It uses involved in watchmaking or jewellery. is one of the three bodies in the world new materials and gives EPMT groups companies operating in certified for watch inspections. them new forms, with a microtechnology and nanotechnology. more contemporary and SMT assembles specialists of the medical More information marked design. engineering industry. theta.obs-besancon.fr Burgundy-Franche-Comté will be represented collectively. Booth M41 (Regional booth More information of CCI Burgundy-Franche-Comté). utinam.fr For more information: www.ephj.ch

TEMIS news 4 TEMIS on the move

Polycaptil now in TEMIS A facility in an ecosystem that is conducive to development

ecognised for its know-how of the diagnosis and manual study and making of innovative ventilation assistance R solutions that combine the technology system designed for of electronics, optics and micro emergency workers treating mechanical engineering, the company founded in cardiac respiratory arrest. 1991 in Besançon is now a subsidiary of the Delta The device was developed in close group from Alsace, the leading manufacturer in the collaboration with Polycaptil and world of optical sensors for industrial processes. Alcis, another company from Since 2011, Polycaptil has a subsidiary: FCE, Besançon, in order to address the employing 18 staff and making printed circuit needs of first aid workers in terms boards and assembly devices, particularly for of ergonomics. The electrome- the medical engineering industry. chanical system and the ad hoc Under the management of Dan Nita, who has software have been developed entirely by Polycaptil. replaced Jean-François Vinchant, 14 engineers and After a test phase that has demonstrated technicians from its designing department work improvement in manual ventilation (to over 95% on mechatronics projects with high added value of effective cycles compared to 7 to 10% without for a wide variety of fields. Vedia System), the product is now undergoing CE marking; Polycaptil will then take charge of From Calais lace to home automation making it before it is sold in the market. and medical engineering: expertise to serve very specialised projects New premises to accompany Whatever the field of application, the same the projects of the future passion for technology drives the work of the From May, the company will enter its building company. covering some 1100 m2 in the TEMIS ecosystem. “30% of our business relates to Calais lace. The investment will be of use to support the Digitising Jacquard looms from the 19th century, technological developments of the company and which are not easy to programme, is exciting accommodate new workers: a new mechatronics work. ” says Dan Nita. Thus, Polycaptil creates a engineer is to be hired this year. matrix of electromechanical actuators that can “Customers come to us with an increasing number simulate the pattern required for lacemaking. The of requests relating to the Internet of things, with component made in Besançon is then incorporated the need to adapt products to Wi-Fi and Bluetooth® into the weaving machine. systems. Our services are more focussed on the Home automation (where technology is used making of smart printed circuit boards that can to improve homes) is also an industry for which the communicate data collected from the outside, company has developed solutions. Already well transfer them to a database and then share them positioned in the making of meal trays for school usefully after that, including on the web.“ points canteens, Polycaptil is increasingly developing out Dan Nita. The new premises were thus technologies for the household appliances of the necessary to accompany major investment planned future: smart systems for roller shutters, swimming to continually master spearheading technology. pools etc. The technological and scientific environment of the TEMIS park will be decisive. Vedia System, an innovative medical device developed with the University Hospital of Besançon and Alcis Contact: POLYCAPTIL Vedia System is another major project on which www.polycaptil.eu the company is working. Devised with a team from the Centre for Clinical Investigation of the University Hospital of Besançon, Vedia System is a smart

5 TEMIS santé

Centre for Clinical Investigation of Besançon (CICB) Biotherapy and technological innovation: dual competency to serve research and industry for healthcare

Meeting with Dr Lionel Pazart, Joint coordinator of the technological innovation module of the CICB of the University Hospital of Besançon

That means there is close and regular CICB is part of themed networks. collaboration with many pure research “The F-CRIN (French Clinical Research Centres for clinical investigation laboratories in the region, such as the Infrastructure Network) coordinates all (CICs) are clinical research FEMTO-ST Institute and the companies the research units on the national level. in TEMIS and the Innov'Health cluster E-CRIN (European Clinical Research organisations that serve of the microtechnology centre (PMT) Infrastructure Network) relates to investigators by allowing them to support innovative projects that are the European level. to carry out their clinical and liable to meet a healthcare need. The existence of these networks is all healthcare research projects the more relevant for rare diseases, Founded in 1992 on the joint initiative of Translational research where, for example, the geographical the National Institute for Healthcare and at the heart of the activities extension they allow makes it possible Medical Research (INSERM) and the of the CICB to constitute patient panels that are General Directorate for Healthcare larger and more representative. For The main mission of the CICB consists (DGOS), the CICs offer investigators more common disorders, the network in supervising research work and (researchers, clinicians etc.) the resources can also be useful to make more rapid promoting the transfer from pure that allow them to reinforce and promote strides, particularly in the case of research to patient applications, which the applications of the results of basic vaccinations, for example, where several is part of translational research. All research to serve patients. centres can be recruited simultaneously the stages of maturation of biotherapy The projects may aim to understand a with the same working methodologies” or medical devices are verified by the disease, where the idea is the result of explains Dr Lionel Pazart. CICB before the first human trials are work in research laboratories, or projects The F-CRIN network has thus accredited initiated. for testing new treatments. several skills networks (in cardiology, The work of the CICB is based on sepsis, thrombosis, rare diseases, synergy between laboratories, the The national network of CICs includes neurology etc.) for a prompt response world of industry, academia and 54 centres differentiated on the basis to public health issues with the setting hospitals. That allows the organisation of their specialities in technological up of multi-centric studies conducted to offer a high-quality approach that innovation (CIC-IT), biotherapy (CIC-BT), in several cities of France and in several encompasses the different stages of epidemiology (CIC-EC), or plural themes European countries. the project and thus be particularly (CIC P). For medical devices, the Tech4Health proactive in the area of translational national network operates as a platform research. of approved services, bringing together “The process can also be of interest to academic expertise in regulation and other medical professionals, particularly evaluation of healthcare technologies, in the area of telemedicine, which to serve the development of medical is precisely aimed at avoiding The Centre for Clinical devices, e-health and biomaterials hospitalisation. ” adds Dr Lionel Pazart. Investigation of Besançon throughout their maturation process. The work methodology naturally and local particularities Tech4Health, a network accredited depends on the different contexts in 2014 by F-CRIN, is coordinated by The CICB is the research organisation of of clinical studies. Prof. Régis Beuscart (University Hospital the University Hospital of Besançon and For biotherapy (such as biological tissue of Lille), Prof. Frédéric Patat (University has the particularity of being certified grafts, blood transfusion or immune Hospital of Tours) and Dr Lionel Pazart by INSERM and DGOS for research in therapy), the steps are very similar of the University Hospital of Besançon. two areas of competency: Technological and codified by a significant body “Tech4Health primarily addresses innovation and biotherapy. of regulation. For technological clinical evaluation after translational That comes as no surprise when you innovation, the evaluation and test research and the stages in the look at the region and its fabric of stages are variable and depend on the development of a new medical device. companies, recognised for their type of technology and its purpose That network makes it possible to list competencies in biomedical engineering (treatment, diagnosis, substitution, the academic skills of each centre and and know-how of microtechnology prevention etc.). and nanotechnology. call on them, individually or collectively A pool of skills that results in depending on specific needs. F-CRIN, E-CRIN, Tech4Health… It coordinates high-level training courses technological innovation and engineering a networked approach to serve healthcare, and naturally and initiates methodological work collaborates with the CICB to develop For greater visibility of the action taken to guarantee the quality of research. ” reliable projects that bring something new. domestically and internationally, the clarifies Dr Lionel Pazart.

TEMIS news 6 Questions to Dr Lionel Pazart

How does a research project a mechanical and microtechnology become a medical device engineer who has worked for that is mass-produced several companies in the medical by a company? engineering field in the region. Proviskin is a company specialised In the best case, a project starts in innovative transcutaneous from a felt healthcare need, and absorption solutions based in the aim is then to set it against the Besançon and co-founded by an clinical reality very early on. Then, engineer from the CICB on the laboratory developments make basis of the work and patents it possible to design prototypes developed there. that meet the requirements and Dr Lionel Pazart The other project in the news is specified needs, followed by a Vedia System, an innovative demonstrator. Their reliability and device for manual ventilation technical efficiency are thus validated. aimed at emergency workers treating cardiac respiratory Manufacturing for clinical investigation can only be arrest, which has been developed by a team from the initiated after project maturation stages are verified University Hospital (Dr Abdo Khoury, Alban De Luca, and validated, and is followed by marketing. Fatimata Sarr) and the CICB, in collaboration with two Concretely, there may be a range of cases. One or more companies: Polycaptil and Alcis. researchers may decide to take their research project further and create a business take their product to Do you take part in events that enable the market. Researchers may turn to a company in the the emergence of innovative projects? field, which has not just medical expertise, but also the resources required for production and marketing. Yes, that has actually been the driver for the organisation We are also approached directly by companies that want in April of the Innovation Days of the University Hospital us to carry out the clinical tests required for the CE of Besançon (coordinated by Dr Bruno Wacogne for CICB marking of their product, and the demonstrative clinical and Fany Chedevergne for the microtechnology centre), trials required for the cost of treatment to be covered with the themes of neurostimulation (Prof. Emmanuel (e.g. by health insurance). Haffen), assisted reproductive technology (Prof. Christophe Roux) and clinical evaluation of medical Could you name a few projects that have devices (Thomas Lihoreau, Stéphanie François). The been developed by local start-ups with which annual meeting, organised jointly by the University Hospital and the CIC, the FEMTO-ST Institute, the you have collaborated? Microtechnology centre and its Innov’Health cluster, The S-Alive project, designed for patients suffering from brings together academic researchers, hospital a lack of saliva or a dry mouth, which can happen after professionals and high-tech industry working for radiotherapy to treat cancer or due to the use of some technological innovation. Tours of clinical departments, mind-altering medication. The project, funded by networking and the B2B meetings that close the event the national agency for research (ANR) is the fruit promote exchanges to analyse the clinical needs and of collaboration between the Maxillofacial Surgery envision the germination of new products. department (Prof. Christophe Meyer and Dr Edouard Euvrard), the Centre for Clinical Investigation of the University Hospital of Besançon, the biology laboratory of the Pharmacy department, the veterinary school of Contact: Centre for Clinical Investigation - Lyon and the company Cisteo Medical, founded during the project. University Hospital of Besançon Cisteo is now a recognised company based in TEMIS www.fc-sante.fr/cicbt-besancon and managed by its founder, Christophe Moureaux,

7 programme in brief 28–29 June Grenoble - France MedFIT First international business conference dedicated to innovative partnerships in the field of medical technology, New clean room MEDFIT will be held from 28 to 29 June in Grenoble. TEMIS and the Innov’Health cluster will attend this major For Cisteo Medical industry event along with e Biotika-ISIFC, Femto Engineering, Miravas, Proviskin, Créatemps, Stemcis, and Statice could Specialised in the development and secure new business streams, partners and experts making of finished medical devices depending on their needs. (implants, catheters, instrumentation, in-vitro diagnosis devices), Cisteo Medical For more information: [email protected] works to customer specifications, under a www.medfit-event.com contractual relationship. Its developments are thus made to measure, covering a number of fields of application: cardiac, spinal, ENT, urology, obesity, plastic surgery etc. 5–6 July Dortmund - In 2012, the company based in TEMIS started the development of class III implants for heart surgery, including design, manufacturing Health Business Connect engineering and CE marking applications. In early 2017, Cisteo Medical grew by acquiring a third clean room of 63 m2 with a The Innov’Health cluster of Burgundy-Franche-Comté and five-axis laser welding machine with helium leak testing designed its German partner, the IVAM cluster, will organise Health for welding implantable titanium devices. The new machine allows Business Connect on 5 and 6 July 2017 in Dortmund. On 5 July, there will be talks in English and/or German the company from Besançon to integrate and offer its customers on the subject of microtechnology for healthcare. In the a service that is as yet rare in Europe. evening, a guided tour of the town and a networking dinner have been planned. Contact: [email protected] On 6 July, there will be pitches, business meetings and a number of other meetings to create partnership opportunities between participants hailing from different countries. The 2016 event has 38 participants from France, Germany, Cobotics to serve human intelligence Italy and other European countries.

After Chronogrip, a collaborative hold an object at a constant force For more information: [email protected] robot that allows users to with no human intervention. www.polemicrotechniques.fr/evenement/ health-business-connect/ manipulate and observe miniature Among other uses, this new tool objects as if they were holding makes it possible to grasp an them in their own hand, Percipio object with constant force, with Robotics has developed a new tool a fixed opening, and maintain October Besançon - France that revolutionises the concept of grasp on an object in vice mode. 13–15 tweezers. They are intended for Objects can also be manipulated watchmakers; after three years of with a feeling of touch in a virtual Hacking Health research, the Teletweezer device (3D) environment for teaching The Microtechnology centre and Grand Besançon will combines human intelligence with manipulation to operators and organise Hacking Health of Besançon on 13, 14 and 15 robotic capabilities to act, carry training them. October 2017 with two themes: “Digital technology and out a task and react depending healthcare” and “Greater independence”. on the environment. The motor Contact: This healthcare innovation marathon is aimed at promoting integrated into the robotic [email protected] the cross fertilisation of the skills of different parties who tweezers applies force against will work together to bring forth innovative projects. the user’s fingers. That force may be used to even out or limit the In the run up to the event, two major events are planned: clasping effort by the  On 30 May, in TEMIS Innovation, from 6 pm to 8 pm, a user, or even health hack meeting on: “Is intellectual property dead?”  On 14 June at ISIFC from 6 pm to 8 pm, on the subject of “Medical design” Other events are being scheduled.

For more information: contact [email protected] or from mid-September on the website: http://hackinghealth.ca/besancon

Information: www.temis.org - +33 (0)3 81 50 46 95 - [email protected]

TEMIS NEWS - May 2017 • www.temis.org • Editor: Jean-Louis Fousseret • Contact: Bruno Favier • Tel. +33 (0)3 81 50 46 95 • Email: [email protected] • Direction de la Technopole - 18, rue Alain Savary - 25000 Besançon • Marketing SedD: Tel. +33 (0)3 81 41 86 69 - Fax: +33 (0)3 81 41 46 51 • Pictures: DR - Fotolia-vege, Agence Bill, David Cesbron/Région Franche-Comté, Benjamin Muller, Reparalux, Phenomen, Lornet, Manufacture VUILLEMIN, Utinam, Percipio Robotics, Polycaptil • Design - Content - Layout: JC. AUGÉ – Tel. +33 (0)3 81 81 59 86 – [email protected] • ISSN no.: 2110-1051.