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Iodoform on Delaying Root Resorption in Primary Molars Without Successors Bichen LIN1,*, Yuming ZHAO2,*, Jie YANG2, Wenjun WANG2, Li-Hong GE2

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Iodoform on Delaying Root Resorption in Primary Molars Without Successors Bichen LIN1,*, Yuming ZHAO2,*, Jie YANG2, Wenjun WANG2, Li-Hong GE2 Dental Materials Journal 2014; 33(4): 471–475 Effects of zinc oxide-eugenol and calcium hydroxide/ iodoform on delaying root resorption in primary molars without successors Bichen LIN1,*, Yuming ZHAO2,*, Jie YANG2, Wenjun WANG2, Li-hong GE2 1 Outpatient Center, Peking University School and Hospital of Stomatology, Beijing 100034, PR China 2 Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, PR China Corresponding author, Li-Hong GE; E-mail: [email protected] The purpose of this study was to compare the effects of zinc oxide-eugenol (ZOE) and calcium hydroxide/iodoform paste (Vitapex), as root canal filling materials in pulpectomy, on delaying the root resorption of primary molars without permanent successors. Animal models without permanent successors were surgically established in beagle dogs. Root resorption was observed via periapical radiographs. The onset of root resorption of primary mandibular molars without successors occurred later (p<0.05) than physiologic resorption. ZOE pulpectomy clearly delayed the root resorption of primary molars without permanent successors (p<0.05), whereas resorption of primary molars with Vitapex pulpectomy started at almost the same time as physiologic resorption. Compared with Vitapex, ZOE was a more effective root canal filling material in delaying the root resorption of primary molars. Keywords: Zinc oxide eugenol, Vitapex, Root resorption, Primary molars without successors iodoform, 30.3% calcium hydroxide, 22.4% silicone oil, INTRODUCTION and 6.9% inert ingredients)6) are commonly used as Tooth agenesis is a prevalent craniofacial congenital root canal filling materials for primary teeth. While malformation in humans. The incidence of agenesis of much has been reported about root canal filling permanent teeth, excluding third molars, ranges from materials used in normal primary teeth, information 3.4% to 10.1%, depending on the population studied1). is scarce concerning root canal filling materials used in Mandibular second premolar, maxillary lateral incisor, primary teeth without permanent successors. and maxillary second premolar have the highest The purpose of this study was to compare the effects susceptibility. of ZOE and Vitapex on delaying the root resorption of In growing individuals, tooth agenesis may primary molars without permanent successors. result in dental malpositioning, periodontal damage, and lack of maxillary and mandibular bone height MATERIALS AND METHODS development; it also has significant aesthetic and functional consequences2). Clinical management of Animal model these children requires maintaining deciduous teeth All the 14 dogs used in this study were purebred male that will facilitate the final phase of corrective therapy. beagles (Beijing Marshall Biotechnology Co., Beijing, Primary molars with missing permanent successors China). They were housed in light- and temperature- must also be retained since they retain bone in an controlled rooms and allowed ad libitum access to food area which may be a site for future transplantation or and water. Their care and the experimental procedures implant therapy3). employed in this study were in accordance with the Clinically, there are no accurate predictors for guidelines of the US National Institutes of Health the survival of primary teeth without successors. It regarding the care and use of animals in research and was reported that only the primary canines —but not those of the Administration Regulations on Laboratory molars— can provide many years of service4). Though Animals of Beijing Municipality. The research protocol exfoliated later than normal primary molars, the roots of this study was reviewed and formally approved by of primary molars without successors are eventually the Biomedical Institutional Review Board of Peking resorbed. The outbreak of pulpitis or apicitis can University (No. LA2010-018). further lead to early tooth loss. Previous study showed Using 10-week-old male beagles each weighing 3.5 that the dental pulp of primary molars might play kg, 14 animal models without permanent tooth germs an important role in the root resorption of primary were established by surgically removing permanent molars without permanent tooth germs. A pulpectomy premolar germs, as described in previous reports7-9). technique has been advocated to retain these diseased For all experimental procedures, the dogs were primary teeth that would otherwise be lost5). A mixture anesthetized by intravenous injection of pentobarbital of zinc oxide and eugenol (ZOE) with or without sodium (30 mg/kg body weight; Sigma-Aldrich, St. formocresol or Vitapex paste (a mixture of 40.4% Louis, MO, USA). The intraoral surgical removal of bilateral mandibular and/or maxillary premolar germs was approached via the full-thickness mucoperiosteal *Authors who contributed equally to this work. Received Feb 5, 2014: Accepted Mar 18, 2014 doi:10.4012/dmj.2014-036 JOI JST.JSTAGE/dmj/2014-036 472 Dent Mater J 2014; 33(4): 471–475 flaps on the lateral aspect of respective jaws. After groups in this study. flap reflection, locations of the premolar germs were Pulpectomy of primary molars was performed on determined from preoperative periapical radiographs the 10th postnatal week, before the onset of physiologic (Figs. 1A, B). The overlying cortical bone was gently root resorption. For the test groups (ZOE and Vitapex), removed with a water-cooled fissure bur at high speed. pulpectomy was performed on the test teeth of 12 Special care was exercised to protect the primary molar beagles. In the control group, the chosen teeth of two roots. Dental follicles were revealed after pieces of bone remaining dogs were left untreated. were gently removed. After isolation with cotton rolls, pulp chambers of Periapical radiographs taken after the procedure the primary teeth were accessed and pulp extirpation confirmed that the tooth buds and dental follicles were was performed using Mani barbed broaches (Mani Inc., completely removed (Figs. 1C, D). The surgical wound Tochigi, Japan). Working length of the root canals was was then washed with normal saline and the flap was estimated from the preoperative periapical radiographs closed. All operations were performed by the first three and determined to be 2 mm short of the radiographic authors. apex. Root canals were gently debrided with Kerr files (Mani Inc.) from #20 to #40 and thoroughly Pulpectomy and root canal filling irrigated with normal saline. After drying with paper To compare the effects of different root canal filling points, the root canals were filled with one of these materials (ZOE and Vitapex) on the root resorption filling materials according to manufacturers’ of primary teeth without successors, the primary instructions: ZOE (Dental Materials Factory of mandibular and maxillary second molars of 12 beagles Shanghai Medical Instruments Co., Shanghai, China) were chosen because these teeth have two roots and or Vitapex (NEO Dental Chemical Products Co., Ltd., their successors can be easily removed. Furthermore, Tokyo, Japan). their physiologic root resorption starts at the same The paste was gently injected into each root time. The primary maxillary third and fourth molars of canal using the manufacturer-supplied syringe, and beagles have three roots; their permanent tooth germs postoperative periapical radiographs were taken. cannot be surgically removed and there were insufficient Access cavity was sealed with ZOE cement and glass tooth samples for statistical analysis. Therefore, the ionomer cement before definitive restoration with primary mandibular and maxillary second molars of Filtek P60 posterior light-cure composite resin (3M each dog were evenly distributed for the test and control ESPE, St. Paul, MN, USA) and bonding by One Coat Fig. 1 Animal model without permanent tooth germs was established in a 10-week-old male beagle. A, C: Right primary maxillary second molars. B, D: Right primary mandibular second molars. A, B: Periapical radiographs taken before intraoral surgery. C, D: Periapical radiographs taken after surgery to confirm complete removal of tooth buds and dental follicles of permanent premolars. Tooth buds and dental follicles of permanent mandibular and maxillary second premolars were surgically removed (arrows). Dent Mater J 2014; 33(4): 471–475 473 Bond (Coltène/Whaledent, Altstätten, Switzerland). Statistical analysis Occlusal adjustment was performed after restoration Mann-Whitney’s U test was used to compare the root was cemented. All procedures were carried out by the resorption onset times between primary molars and first three authors. primary molars without permanent successors. Wilcoxon signed-rank test was applied to evaluate the effects Radiographic observation and determination of root of different root canal filling materials in delaying resorption root resorption of primary molars without permanent All periapical films were taken by the same technician successors. All statistical analyses were carried out using the bisecting angle technique with projection using SPSS software (version 17.0; SPSS Inc., Chicago, angles of −37° (mandibular) and +37° (maxillary) and IL, USA). Differences were considered statistically an exposure time of 0.10 s. Periapical films were taken significant when the critical value reached a level of every week postsurgery until all the primary molars had p<0.05. exfoliated. Early resorption was indicated by a blurring of the root and periapical tissue, and complete root RESULTS
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