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BRS Annual Meeting Programme & Abstracts 2011

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BRS Annual Meeting Programme & Abstracts 2011 3rd Joint Meeting of the Bone Research Society and the British Orthopaedic Research Society 27-29 June 2011 Cambridge, UK Final Programme and Abstracts Bone Research Society British Orthopaedic Research Society www.brsoc.org.uk www.borsoc.org.uk The Society (formerly known as the Bone and Tooth Society) is The British Orthopaedic Research Society (BORS) is a the oldest and largest scientific society in Europe that is multidisciplinary association founded in 1961 and devoted to dedicated to further research into clinical and basic science pursuing research relevant to orthopaedic and musculoskeletal problems related to mineralised tissues. The meeting attracts a surgery. The research interests of its membership (currently over wide audience from throughout the UK and, increasingly, from 700) are varied and include: continental Europe and further afield. The presentations are Biological Science traditionally a balance between clinical and laboratory-based Biomechanics studies. The participation of young scientists and clinicians is Osteo-articular Pathology actively encouraged. Biotribology Molecular Biology Bioengineering Committee 2011 Medical Imaging President: Jonathan Tobias (Bristol) Patient Management President Elect: Tim Arnett (London) Secretary: Eugene McCloskey (Sheffield) Treasurer: Nigel Loveridge (Cambridge) Committee 2011 President: Allen Goodship (London) Jacqueline Berry (Manchester) Secretary: Gordon Blunn (London) Allie Gartland (Sheffield) Treasurer: Xuebin Yang (Leeds) Celia Gregson (Bristol) Vicky MacRae (Edinburgh) Mark Birch (Newcastle upon Tyne) Deborah Mason (Cardiff) Ben Bolland (Southampton) Isabel Orriss (London) Bruce Caterson (Cardiff Sanjeev Patel (London Mark Gaston (Edinburgh) Ken Poole (Cambridge) Richie Gill (Oxford) Wasim Khan (London) Iain McNamara (Cambridge) Tony Miles (Bath) Brigitte Scammell (Nottingham) Hamish Simpson (Edinburgh) Membership Enquiries Membership Enquiries Eugene McCloskey Tel: 0115 8231115 Email: [email protected] Fax: 0115 8231118 Email: [email protected] Next Year’s BRS Meeting Next BORS Meeting Manchester, 1-4 July 2012 See website for details Jointly with the National Osteoporosis Society and Paget’s Association 2 Contents Supporters ................................................... 4 Outline programme .................................... 5 Programme: Monday .............................................. 8 Tuesday ........................................... 10 Wednesday ...................................... 13 Invited speaker abstracts .......................... 17 Submitted abstracts: Oral communications ...................... 23 Posters ............................................. 37 Invited speaker profiles ............................ 74 Exhibitor profiles ...................................... 78 Organising Committee Nigel Loveridge (Cambridge, UK) Gavin Clunie (Ipswich, UK) Juliet Compston (Cambridge, UK) Allen Goodship (London, UK) Iain McNamara (Cambridge, UK) Ken Poole (Cambridge, UK) Jonathan Reeve (Cambridge, UK) Neil Rushton (Cambridge, UK) The text of the abstracts is reproduced as submitted. Any tables and figures will be included with the published version, which for BORS will be the Journal of Bone and Joint Surgery (Br) and for BRS the online journal Frontiers in Bone Endocrinology. The opinions and views expressed are those of the authors and have not been verified by the meeting Organisers or by the Societies, who accept no responsibility for the statements made or the accuracy of the data presented. 3 Supporters The Bone Research Society and the British Orthopaedic Research Society are extremely grateful to the following companies who have agreed to support the meeting. Further information about the exhibiting companies is given at the end of this book. GOLD SPONSORS Amgen Servier SILVER SPONSOR ApaTech/Baxter BRONZE SPONSOR Heraeus OTHER SUPPORTERS Bose Company of Biologists Eli Lilly Furlong Research Charitable Foundation GE Healthcare LUNAR IDS Instron Materialise Medtronic Objective Imaging Orthovita Pathway Diagnostics Ranier Skyscan/e2v Scientific Instruments Vertec Scientific Zwick Testing 4 Outline Programme All sessions in West Road Concert Hall unless otherwise indicated Monday 27 June 10:00 Registration/Coffee/Poster hanging 10:40 Welcome 10.45 Keynote Lecture 11:15 Symposium 1 The Bone and Joint Decade: Closed Chapter or Open Book? 12:30 Lunch and Posters (odd-numbered boards) 13:45 Symposium 2 The 4Ms: Materials, Mineralisation, Microdamage and Mechanics 15:20 Tea and Posters 16:15 Oral Communications 17:15 New Investigators‟ Session Career pathways - examples and discussions 18:30 End 19:30-23:00 Quiz Night/Buffet Supper Murray Edwards Hall 5 Tuesday 28 June 08:30 Satellite 1 New Insights in the Treatment of Postmenopausal Osteoporosis Supported by Servier West Road Concert Hall 09:30 Clinical Update 1 Oral Communications (basic science) Divinity Lecture Theatre West Road Concert Hall (to 10:20) (to 10:30) 10:20 Coffee and Posters (even-numbered boards) 11.15 Symposium 3 Cell-Cell Communication in Aged Skeletal Elements West Road Concert Hall 12.30 Lunch and Posters (even-numbered boards) 13:30 Clinical Update 2 Oral Communications (basic science) Divinity Lecture Theatre West Road Concert Hall (to 14:45) (to 14:50 14:45 Break 15:00 Symposium 4 Symposium 5 Obesity, Energy Metabolism and Bone Bone Graft Substitutes West Road Concert Hall Divinity Lecture Theatre 16:15 Tea and Posters (even-numbered boards) 16:45 Clinical cases and clinical research Oral Communications (basic) Divinity Lecture Theatre West Road Concert Hall (to 17:35) 17:45 Satellite 2 A Force Against Fracture: New Perspectives in Preventing Bone Loss Supported by Amgen West Road Concert Hall 18:45 End 19:45-22:30 Conference Dinner Cripps Hall, Queen‟s College 6 Wednesday 29 June 09:00 Oral Communications BRS Oral Communications BORS Divinity Lecture Theatre West Road Concert Hall 10:10 Coffee and Posters 11:00 BRS Dent Lecture West Road Concert Hall 11:30 Symposium 6 Joint Development and Disease West Road Concert Hall 12:45 Lunch and posters 13:40 BRS AGM BORS AGM Divinity Lecture Theatre West Road Concert Hall 14:00 Oral Communications BRS Oral Communications BORS Divinity Lecture Theatre West Road Concert Hall 15:00 Oral Posters West Road Concert Hall 16:00 Awards West Road Concert Hall 16 :15 End of meeting Buses to Cambridge Station 7 Programme 16:15 OC1 All sessions in West Road Concert Hall unless otherwise indicated OSTEOCYTES PROMOTE OSTEOBLAST PROLIFERATION DIRECTLY AND EXERT A Monday 27th June DISTINCT EFFECT WITH MECHANCIAL 10:00 Registration and coffee STRAIN RFL Suswillo, SCF Rawlinson*, GP Dowthwaite, Poster hanging LE Lanyon, AA Pitsillides London 10:40 Welcome Nigel Loveridge (Cambridge, UK) 16:25 OC2 ELEVATED SCLEROSTIN LEVELS IN 10:45 Keynote Lecture INDIVIDUALS WITH HIGH BONE MASS Chairs: Juliet Compston (Cambridge, UK) & Allen CL Gregson*, KES Poole, SA Steel, J Ayuk, Goodship (London) EV McCloskey, WD Fraser, JH Tobias Bristol; Cambridge; Hull; Birmingham; Sheffield; Sir Michael Berridge Liverpool 11:15 Symposium 1 16:35 OC3 The Bone and Joint Decade: Closed Chapter or MARKED REDUCTION IN THE EXPRESSION Open Book? OF SCLEROSTIN IN OSTEOCYTES CLOSE TO THE SITE OF FEMORAL NECK FRACTURES Chairs: David Marsh (London, UK) & Eugene J Power, M Parker S Papapoulos, R van Bezooijen, McCloskey (Sheffield, UK) J Reeve, N Loveridge* Cambridge; Peterborough; Leiden 11:15 Nigel Arden (Southampton, UK): Osteoarthritis 16:45 OC4 11:35 John Kanis (Sheffield, UK): Osteoporosis RESULTS OF BONE MORPHOGENETIC PROTEIN (BMP-7) ALONE OR IN 11:55 Keith Willett (Oxford, UK): Trauma COMBINATION WITH AUTOLOGOUS BONE GRAFT (ABG) FOR THE TREATMENT OF 12:15 Panel discussion LONG BONE FRACTURE NON-UNIONS A Shoaib*, MA Rashid, O Lahoti, AFG Groom, 12:30 Lunch and Posters (odd-numbered boards) SL Phillips London 13:45 Symposium 2 The 4Ms: Materials, Mineralisation, 16:55 OC5 Microdamage and Mechanics EFFECTS OF CHRONIC SYSTEMIC METAL EXPOSURE ON WHOLE BODY BONE Chairs: Nigel Loveridge (Cambridge, UK) & MINERAL DENSITY AND BONE TURNOVER Andrew McCaskie (Newcastle, UK) IN THE LATE PERIOD AFTER METAL-ON- METAL HIP RESURFACING 13:45 Chris Burgoyne (Cambridge, UK): An Engineer‟s J Prentice*, M Clark, I Stockley, JM Wilkinson view Sheffield 14:05 David Burr (Indianapolis, USA): Bone 17:05 OC6 microdamage HIGH FAILURE RATES WITH A LARGE DIAMETER HYBRID METAL ON METAL 14:25 Peter Fratzl (Potsdam, Germany): Bone materials TOTAL HIP REPLACEMENT: CLINICAL, RADIOLOGICAL AND RETRIEVAL ANALYSIS 14:45 John Currey (York, UK): A Biologist‟s view BJRF Bolland*, DJ Culliford, DJ Langton, JPS Millington, NK Arden, JM Latham 15:05 Panel discussion Southampton; Newcastle; Oxford 15:20 Tea and Posters (odd-numbered boards) 17:15 New Investigators‟ Session Career pathways - examples and discussions 16:15 Oral Communications This short informal session is designed for both Chairs: Tim Arnett (London, UK) & Xuebin Yang non-clinical and clinical PhD students and Post- (Leeds, UK) docs in their early research career. 8 We are inviting 3 speakers who have established careers and who have taken different career paths; one lab-based scientist, one clinical scientist, and one clinician researcher. Each will speak for 15 minutes outlining their career path to date, identifying the key decisions which they have made along the way - the good decisions and the not so good decisions (if any!), and reflect upon if they were to embark upon the same career now, how the system might have
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