Curriculum Vitae

Dr. SABA ABDI

Assistant Professor, Department of College of , King Saud University P.O. Box

22452, 11495. Phone (Off.): 011- 8050884 Cellular phone: 0556464383

Emails: [email protected]

PERSONAL DATA

Place of Birth : Lucknow , India

Nationality : Indian

EDUCATION

Ph.D in Biochemistry (2000) , Aligarh Muslim University ,India. Concentrations: Nucleic Acid Immunology Dissertation: Studies on Free Radical Modified Human DNA

M.Sc in Biotechnology(1995), Aligarh Muslim University, India. Concentrations: Proteomics Thesis: Isolation and characterization of Hen Egg White Lysozyme

B.Sc in (1993), Aligarh Muslim University, India

TEACHING EXPERIENCE:

2006 to date: Assistant Professor, Biochemistry, King Saud University, Saudi Arabia Course: Various biochemistry courses at Graduate and Post Graduate level( enzymology ,molecular biology, endocrinology , biochemistry of specialized tissue , biomembrane, biochemistry of fluids, biomolecules, Immunology , Molecular genetics and metabolism).

2005-2006: Assistant Professor, Prince Sultan University, Saudi Arabia. Course : General Chemistry

RESEARCH EXPERIENCE:

During the course of my PhD work I gained experience in nucleic acid immunology. I am conversant with the techniques involved in immunology such as the ELISA, Immune-blotting, dot-blotting,immune -fluorescence,immuno- precipitation,Counter immune electrophoresis, immunodiffusion, band shift assay, gel retardation assay, ion exchange chromatography and affinity chromatography.

I am also well acquainted with basic molecular biology techniques such as isolation of mammalian DNA, bacterial DNA and plasmid. Characterization of various nucleic acids using techniques such Agarose gel electrophoresis, PAGE, alkaline sucrose density gradient ultracentrifugation, PCR, RT-PCR.

PUBLICATIONS:

1. Yakout, S. M., Alharbi, F., Abdi, S., Al-Daghri, N. M., Al-Amro, A., & Khattak, M. (2020). Serum minerals (Ca, P, Co, Mn, Ni, Cd) and growth hormone (IGF-1 and IGF-2) levels in postmenopausal Saudi women with osteoporosis. Medicine, 99(27), e20840. https://doi.org/10.1097/MD.0000000000020840

2.Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms N. M.Al-Daghri, .K. Mohammed, I. Bukhari, M. Rikli, Saba Abdi, M. G. A.Ansari, S.Sabico, S.D. Hussain, A. Alenad,Y. Al-Saleh, M. S. Alokail. Nutrition, Volume 63- 64, July- August 2019, pp 148-154

3.Effect of Honey in Improving Breast Cancer Treatment and Gene Expression Modulation of MMPs and TIMPs in Triple-Negative Breast Cancer Cells Rafa Almeer,*, A. Alqarni, S. Alqattan S. Abdi, S. Alarifi , Z.Hassa and A. Semlali. Pakistan J. Zool., vol. 50(6), pp 1999- 2007, 2018

4.Glutamate signaling defects in propionic acid-orally administered to Juvenile rats as an experimental animal model of autism" Al-Suwailem, E., Abdi, S., Bhat, R.S. et al. Neurochem. J. (2019) 13: 90. https://doi.org/10.1134/S1819712419010021

5.Nora Alyahri, Saba Abdi, Wajahatullah Khan, Mohamed Elrobh, Mohammed H Addar,, Zeneb A babay, Mohamed Alanazi , Sooad Aldaihan,, Jilani Shaik ; Maha Arafa , Reddy , Arjumand Warsy.Novel Associations between BRCA1 variants c.181 T>G (rs28897672) and Ovarian Cancer Risk in Saudi females Journal of Medical Biochemistry, (Accepted on 14-01- 2018, Ref.: Ms. No. JMEDBIOCHEM-D-17-00054R1)

6.Al-Suwailem E, Abdi S, El-Ansary A. Sex differences in the glutamate signaling pathway in juvenile rats. J Neuro Res. 2017;00:1–8. https://doi.org/10.1002/jnr.24144 (Impact Factor: 2.481)

7. M. Aslam, Moinuddin, S. Abdi, S. Siddique & A. Ali (2002).“Effect of radio/chemotherapy on the level of anti-ROS- DNA antibodies in cancer patients”. J Clin. Radiotherapy oncology. 2, 17-22.

8..H. Ahsan, S. Abdi & A. Ali.“ Recognition of DNA Arginine photoadduct by Anti-DNA Auto antibodies in systemic lupus erythematosus”. Indian J. Med. Res., May 2002, pp.201-211

9. S. Abdi, H. Ahsan & A. Ali (2000). “Studies on antibodies against reactive oxygen species modified human Placental DNA”. J. Biochem, Mol. Biol. & Biophys., Vol. 4, pp.433-443

10. S. Abdi, A. Ali. “Role of ROS modified human DNA in the Pathogenesis and Etiology of Cancer”. Cancer Letter 142 (1999) 1-9

Supervision of Research Projects:

Completed Projects:

1. lmpact of oral vitamin D supplementation on serum Carboxypeptidase N and nitric-oxide levels in Saudi patients(MSc students research project ,Completed in December 2019)

2. Association of lL-6 and TNFq gene polymorphisms with the risk of Alzheimer's disease in Saudi subjects (MSc students research project ,Completed in December 2019 )

3. Association between Cadmium and Bone Mineral Density in Postmenopausal Osteoporotic Saudi subjects (MSc students research project ,Completed in November 2019))

4. NPST,KSU funded project titled “Association of gene polymorphisms in the PTH, RANKL and calcium metabolism pathways in Saudi subjects with osteoporosis” (completed in June, 2017)

5. Screening for biochemical markers of bone turnover in postmenopausal osteoporotic Saudi subjects (MSc students research project, completed in June, 2017)

6. Association study of Single Nucleotide Polymorphism of RANK, RANKL and OPG genes in postmenopausal Osteoporotic Saudi Subjects (MSc students research project, completed in June, 2017)

7. Effect of vitamin D binding protein polymorphisms and vitamin D supplementation on serum vitamin D concentration in Saudi T2DM subjects (MSc students research project, Completed inJune,2017)

8. Vitamin D receptor and Calcium sensing receptor gene polymorphisms in postmenopausal Saudi women (MSc students research project, Completed in June 2016)

9. Polymorphisms in BRCA1 & TP53 Genes and Ovarian Cancer Risk in Saudi Females( KAUST funded Msc research project MSc students, Completed in June 2015)

10. Association Study of Single Nucleotide Polymorphism of PTH Gene in Osteoporosis Among Saudi Population ( MSc students research project, Completed in June 2012)

11. A Study on the role of Map Kinases in progression of asthma in murine model.(Msc research project , completed in June 2012)

PRESENTATIONS IN CONFERENCES:

• Association study of Single Nucleotide Polymorphism of RANKL and OPG Genes in Postmenopausal Osteoporotic Saudi Subjects. Rawan A. BinBaz, Saba Abdi, Abdul Khader Mohamme1, Osama E. Amer, Naji Aljohani, Nasser M. Al-Daghri,. . Oral Presentation during the 4th International Conference of the Saudi Osteoporosis Society on 4-5 April, 2018

• Nasser Al-Daghri, Maryam Rikli, Saba Abdi, Abdul Khader Mohammed, Majed S.Alokail (2017) Common Genetic Variants in Vitamin D protein (DBP) Gene Modify the Response to Vitamin D Supplementation.

First prize in the category of oral presentations at The Fifth Annual Clinical Congress of the Gulf Chapter of the American Association of Clinical Endocrinologists, as presented by Shaun Louie Sabico (October, 2017)

• Saba Abdi, Ranya Alhaj Dawod, Abdul Khader Mohammed, Majed S.Alokail and Nasser M. Al-Daghri (2015) Association of Gene variants in the Vitamin d Receptor and calcium Sensing Receptor Gene in Postmenopausal Saudi Women with Osteoporosis

Poster presentation at The 18th Workshop on Vitamin D, Delft, Netherlands(April, 2015)

• Saba Abdi (2009) “Monoclonal Antibodies Against Tumor specific antigens in breast cancer”

Abstract accepted for poster presentation at the 24thmeeting of Saudi Biological Society, at Taibah University, Madina Al Munawwarah , Saudi Arabia

• Saba Abdi and Asif ali (1997)“Antigeninity of Free Radical Modified Human Placental DNA and its Role in Cancer”

Abstract accepted for oral presentation at International Symposium on Free Radicals in Medicine and Biology, RNT Medical College, Udaipur, India

• Saba Abdi and Asif Ali (1997) “Studies on Antibodies against Reactive Oxygen Species Modified Human Placental DNA”

Abstract accepted for poster presentation of Society of Biological chemists (India) 1997 Annual Meeting.

• Saba Abdi and Asif Ali (1998) “Detection of Oxidative lesions in DNA Isolated from Lymphocytes of Cancer Patients”

Abstract accepted for poster presentation at Society of Biological chemist (India) 1998 Annual Meeting.

GRANTS AND FELLOWSHIPS: • Principle Investigator in KSU National Plan for Science, Technology and Innovation (NPST) project N0. 12-BIO2646 , Titled : Association of Gene Polymorphism in the PTH,RANKLand calcium metabolismpathways in Saudi Osteoptic Subjects (To date )

• Merit Scholarship during Masters programme at at interdisciplinary Biotechnology Unit, A.M.U. Aligarh.

• Qualified GATE-96 conducted by University Grant Commission (UGC), Government of India, New Delhi.

• Research assistant fellowship by a DBT sponsored project entitled “ Monoclonal antibodies against DNA modified by Reactive Oxygen species: Molecular Probes for aging and cancer”.

• Senior Research Fellowship by an ICMR sponsored project entitled “ A Systematic Study on the photo-conjugation between amino acids and nucleic acids and their possible role in the pathogenesis of SLE”.