Table 2. List of downregulated in PVH in response to LPS and restraint. LPS Restraint LPS Restraint calcium/calmodulin-dependent kinase II, beta uridine monophosphate kinase, pseudogene preproenkephalin 1 insulin-like growth factor binding protein 7 RAS protein-specific guanine nucleotide-releasing factor 1 TYRO protein tyrosine kinase binding protein vesicular inhibitory amino acid transporter cholecystokinin protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), protein kinase C, zeta insulin-like growth factor binding protein 7 AMPA 1 alpha isoform protein that interacts with C kinase 1 leptin leptin interferon gamma induced GTPase Vav2 oncogene insulin-like growth factor binding protein 5 neuropeptide Y creatine kinase, brain ATPase, Na+/K+ transporting, alpha 1 polypeptide neuropeptide Y nel-like 2 homolog (chicken) Rad51 homolog (S. cerevisiae) corticotropin releasing hormone receptor putative phosphatase macrophage stimulating 1 receptor (c-met-related tyrosine kinase) AMPA 1 RAB11B, member RAS oncogene family calcium/calmodulin-dependent protein kinase II, beta neuropeptide Y receptor Y1 RAN GTPase activating protein 1 TRAF-interacting protein glutamate receptor, ionotropic, NMDA1 (zeta 1) visinin-like 1 protein kinase C, epsilon receptors phosphatidylserine synthase 1 pyruvate kinase 3 testis specific protein kinase 1 estrogen related receptor, alpha neuropeptide Y receptor Y1 protein kinase C and casein kinase substrate in neurons 1 glutamate receptor, ionotropic, kainate 5 (gamma 2) bombesin-like receptor 3 neuronal tyrosine/threonine phosphatase 1 nicotinic acetylcholine receptor beta 2-subunit (promoter)

Neuropeptides/neurotransmitters/ growth hormone releasing hormone

Signaling molecules protein kinase C, epsilon guanine nucleotide binding protein, alpha o gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1

signal transducing adaptor molecule (SH3 domain phosphatidylinositol 3-kinase, regulartory subunit, calcium channel, voltage-dependent, T type, alpha 1G subunit potassium voltage-gated channel, subfamily Q, member 2 and ITAM motif) 2 polypeptide 2 (p85 beta) transient receptor protein 4 calcium channel, voltage-dependent, T type, growth factor receptor bound protein 2 Tnf receptor-associated factor 5 potassium voltage-gated channel, subfamily Q, member 2 alpha 1G subunit Ion mitogen activated protein kinase kinase 7 protein tyrosine phosphatase, receptor type, D inositol 1,4,5-triphosphate receptor 1 protein kinase C, epsilon channels calcium channel, voltage-dependent, T type, alpha 1G subunit potassium inwardly-rectifying channel, subfamily J, member 1 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha potassium voltage gated channel, shaker related subfamily, guanine nucleotide binding protein, alpha inhibiting 2 beta member 1

Mus musculus, Similar to sequestosome 1, clone MGC:5968 endonuclease G small inducible cytokine subfamily D, 1 B-cell leukemia/lymphoma 2 related protein A1d myogenic factor 6 poly(rC)-binding protein 4 alpha 4 lipopolysaccharide binding protein metal response element binding transcription factor 2 nuclear receptor subfamily 1, group H, member 2 interferon gamma induced GTPase tumor necrosis factor (ligand) superfamily, member 12 X-ray repair complementing defective repair in Chinese bagpipe homeobox gene 1 homolog (Drosophila) killer cell lectin-like receptor, subfamily A, member 7 interferon gamma induced GTPase hamster cells 1 metal response element binding transcription factor 2 small inducible cytokine A21a (leucine) melanoma antigen, family A, 7 brachyury 2 RNA polymerase II 4 (14 kDa subunit) stromal cell derived factor 1 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) tripartite motif protein 28 Rad51 homolog (S. cerevisiae) transforming growth factor beta regulated gene 1 early growth response 1 zinc finger protein 90 lymphocyte antigen 6 complex, locus E NK6 transcription factor related, locus 2 (Drosophila) myogenic factor 6 prostaglandin D2 synthase (21 kDa, brain) ubiquilin 2 nuclear receptor 2 reticulon 4 homeo box A5 aryl hydrocarbon receptor nuclear translocator interleukin 25 aryl hydrocarbon receptor nuclear translocator-like fibronectin 1

ubiquitin-activating enzyme E1, Chr X Immune molecules neural retina leucine zipper gene formyl peptide receptor-like 1 formyl peptide receptor-like 1 hairy and enhancer of split 1, (Drosophila) Burkitt lymphoma receptor 1 immunoglobulin kappa chain variable 28 (V28) DNA polymerase alpha 2, 68 kDa interleukin 9 receptor pre B-cell leukemia transcription factor 1 LIM homeobox protein 3 small inducible cytokine A6 Tnf receptor-associated factor 5 forkhead box M1 cytochrome b-245, alpha polypeptide ligand D site albumin promoter binding protein Nef-associated factor 1 Nef-associated factor 1 myogenin immunoglobulin kappa chain variable 28 (V28) histocompatibility 2, class II antigen E beta lymphocyte antigen 6 complex tumor necrosis factor (ligand) superfamily, member 10 (TRAIL) or RNA binding Transcription factors/DNA POU domain, class 3, transcription factor 2 POU domain, class 2, transcription factor 1 kit ligand nucleolin pre B-cell leukemia transcription factor 1 retinoid X receptor beta tripartite motif protein 21 prostaglandin E synthase peroxisome proliferative activated receptor, gamma, nuclear receptor subfamily 4, group A, member 2 stromal cell derived factor 1 (CXCL12) coactivator 1 zinc finger protein 38 transcriptional regulator, SIN3B (yeast) Kruppel-like factor 7 (ubiquitous) apolipoprotein B editing complex 1 interferon activated gene 204 pre B-cell leukemia transcription factor 1 general transcription factor IIH, polypeptide 1 (62kD subunit) aristaless 3 RPB5-mediating protein