Corporate Information / Stock Information As of March 31, 2016

Corporate Headquarters Santen Pharmaceutical Co., Ltd. Composition of Shareholders Grand Front Tower A, By number of shares By number of shareholders 4-20 Ofuka-cho, Kita-ku, Osaka 530-8552, Individual 0.0% 0.3% Financial institutions investors Treasury stock 0.0% 0.2% Treasury stock URL: http://www.santen.com 9.4 Securities firms TEL: +81-6-6321-7000 (Main) % 0.7% 35.5% Other institutions +81-6-4802-9360 (PR and IR) Financial 2.3% institutions E-MAIL: [email protected] 45.0% Foreign investors Foreign 96.5% investors Individual Established 1890 1.2% investors 8.9% Securities firms Paid-in Capital ¥7,695 million Other institutions Number of Employees 3,463 (non-consolidated: 1,891) Number of Shares Issued 414,191,515 Major Shareholders Number of Shareholders 23,533 Number of Percentage of Name shares held ownership Thousands Stock Exchange Listings Tokyo Japan Trustee Service Bank, Ltd. 31,249of shares 7.5% Ticker Code 4536 State Street Bank and Trust Company 505223 24,029 5.8 The Master Trust Bank of Japan, Ltd. 16,789 4.1 Transfer Agent Osaka Corporate Agency Division, Nippon Life Insurance Company 10,662 2.6 Mitsubishi UFJ Trust and Banking Corporation The Bank of Tokyo-Mitsubishi UFJ, Ltd. 10,605 2.6 6-3, Fushimi-cho 3-chome, Chuo-ku, Ono Pharmaceutical Co., Ltd. 9,307 2.3 Osaka 541-8502, Japan Daiichi Sankyo Company, Ltd. 9,180 2.2 Development Bank of Japan Inc. 8,275 2.0 National Mutual Insurance Federation of Agricultural Cooperatives 7,121 1.7 State Street Bank West Clint–Treaty 505234 6,979 1.7

Stock Price Range (Yen) Monthly basis

2,500

2,000

1,500 TOPIX (Tokyo stock price index) 1,000

500

0 2011/4 2012/4 2013/4 2014/4 2015/4 2016/4 (Year/Month)

Trading Volume (Thousands of shares) Monthly basis

48,000

36,000

24,000

12,000

0 2011/4 2012/4 2013/4 2014/4 2015/4 2016/4 (Year/Month)

Yearly High and Low Prices

2012 2013 2014 2015 2016 High (yen) 731 1,010 1,230 2,163 2,064 Low (yen) 555.6 666 813 1,262 1,423

Notes: 1. Calendar years. 2. Stock prices for 2016 are for the period to the end of June. 3. Stock price and trading volume from July 16, 2013 are those listed on the ; prior to this date are those listed on the Osaka Securities Exchange. 4. Santen conducted a five-for-one share split of ordinary shares on the effective date of April 1, 2015. Figures for stock price and trading volume from before the share split have been adjusted using the share split ratio.

Santen Pharmaceutical Co., Ltd. Annual Report 2016 111 Business Bases As of August 2, 2016

Corporate Headquarters and Group Companies Location

Corporate Headquarters Japan

Claire Co., Ltd. Japan

Santen Business Services Co., Ltd. Japan

Santen Eye Care Co., Ltd. Japan

Santen Holdings U.S. Inc. U.S.A.

Santen Inc. U.S.A.

Advanced Vision Science, Inc. U.S.A.

Santen Holdings EU B.V.

Santen Oy

Santen S.A.S.

Santen GmbH

SantenPharma AB

Santen SA Switzerland

Santen S.r.l. Italy

Santen UK Limited U.K.

Santen Pharmaceutical , S.L. Spain

Santen Pharmaceutical () Co., Ltd. China

Santen Pharmaceutical Sales & Marketing (Suzhou) Co., Ltd. China

Santen Pharmaceutical Korea Co., Ltd. Korea

Taiwan Santen Pharmaceutical Co., Ltd.

Santen Private Limited India

Santen Pharmaceutical Asia Pte. Ltd.

SANTEN () CO., LTD. Thailand

SANTEN PHARMA SDN. BHD. Malaysia

SANTEN INC. Philippines

Other Office

Ho Chi Minh City Representative Office Vietnam

112 Santen Pharmaceutical Co., Ltd. Annual Report 2016 Plants and Laboratories

Noto Plant (Japan) Shiga Productoduct SupplySupply CenterCenter (Japan)(Japan)

Tampere Plant (Finland) Suzhou Plant (China) Nara Research and Development Center (Japan)

Santen Pharmaceutical Co., Ltd. Annual Report 2016 113