Mild Cognitive Impairment (Mci) and Dementia February 2017
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Risk Factors for the Progression of Mild Cognitive Impairment to Dementia
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Clin Geriatr Manuscript Author Med. Author Manuscript Author manuscript; available in PMC 2018 April 24. Published in final edited form as: Clin Geriatr Med. 2013 November ; 29(4): 873–893. doi:10.1016/j.cger.2013.07.009. Risk Factors for the Progression of Mild Cognitive Impairment to Dementia Noll L. Campbell, PharmDa,b,c,d,*, Fred Unverzagt, PhDe, Michael A. LaMantia, MD, MPHb,c,f, Babar A. Khan, MD, MSb,c,f, and Malaz A. Boustani, MD, MPHb,c,f aDepartment of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, IN, USA bIndiana University Center for Aging Research, Indianapolis, IN, USA cRegenstrief Institute, Inc, Indianapolis, IN, USA dDepartment of Pharmacy, Wishard Health Services, Indianapolis, IN, USA eDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA fDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Keywords Mild cognitive impairment; Dementia; Risk factors; Genetics; Biomarkers Introduction As identified in previously published articles, including those published in this issue, the detection of early cognitive impairment among older adult populations is worthy of diagnostic and clinical recognition. Several definitions and classifications have been applied to this form of cognitive impairment over time1–4 including mild cognitive impairment (MCI),4–6 cognitive impairment no dementia,7,8 malignant senescent forgetfulness,9 and age-associated cognitive decline.10 -
Depression and Delirium of the Older Adult Interprofessional Geriatrics
3/1/2018 Interprofessional Geriatrics Training Program Depression and Delirium of the Older Adult HRSA GERIATRIC WORKFORCE ENHANCEMENT FUNDED PROGRAM Grant #U1QHP2870 EngageIL.com Acknowledgements Authors: Curie Lee, DNP, AGPCNP-BC, RN L. Amanda Perry, MD Editors: Valerie Gruss, PhD, APN, CNP-BC Memoona Hasnain, MD, MHPE, PhD Learning Objectives Upon completion of this module, learners will be able to: 1. Summarize the difference between delirium and depression in older adults 2. Discuss the use of standardized tools for measuring cognitive, behavioral, and/or mood changes to confirm diagnoses 3. Discuss the structured assessment method to make a differential diagnosis based on the clinical features of delirium and depression 4. Apply management principles according to pharmacologic/ nonpharmacologic strategies 5. Identify materials to educate patients and family/caregivers 1 3/1/2018 Delirium vs. Depression • Delirium and depression can coexist but are not the same diagnosis • Both have Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for diagnosis: • Delirium is the acute onset of behavioral changes and/or confusion and often has an organic cause; resolution is often as abrupt as onset • Depression can be acute or insidious in onset and can last for years; though pathology can exacerbate the depression, it is not the cause of the depression Note: Depression in the geriatric population can be confused with delirium or dementia Delirium Delirium: Definition DSM-5: Five Key Features of Delirium 1) Disturbance in attention and awareness 2) Disturbance develops over a short period of time, represents a change from baseline, and tends to fluctuate during the course of the day 3) An additional disturbance in cognition Continued on next slide.. -
Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
Research Articles: Neurobiology of Disease Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance https://doi.org/10.1523/JNEUROSCI.2574-18.2019 Cite as: J. Neurosci 2019; 10.1523/JNEUROSCI.2574-18.2019 Received: 5 October 2018 Revised: 25 March 2019 Accepted: 11 April 2019 This Early Release article has been peer-reviewed and accepted, but has not been through the composition and copyediting processes. The final version may differ slightly in style or formatting and will contain links to any extended data. Alerts: Sign up at www.jneurosci.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Copyright © 2019 Passamonti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. 1 Neuroinflammation and functional connectivity in Alzheimer’s disease: 2 interactive influences on cognitive performance 3 4 L. Passamonti1*, K.A. Tsvetanov1*, P.S. Jones1, W.R. Bevan-Jones2, R. Arnold2, R.J. Borchert1, 5 E. Mak2, L. Su2, J.T. O’Brien2#, J.B. Rowe1,3# 6 7 Joint *first and #last authorship 8 9 10 Authors’ addresses 11 1Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK 12 2Department of Psychiatry, University of Cambridge, Cambridge, UK 13 3Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, -
Relationship Between the Postoperative Delirium And
Theory iMedPub Journals Journal of Neurology and Neuroscience 2020 www.imedpub.com Vol.11 No.5:332 ISSN 2171-6625 DOI: 10.36648/2171-6625.11.1.332 Relationship Between the Postoperative Delirium and Dementia in Elderly Surgical Patients: Alzheimer’s Disease or Vascular Dementia Relevant Study Jong Yoon Lee1*, Hae Chan Ha2, Noh June Mo2, Hong Kyung Ho2 1Department of Neurology, Seoul Chuk Hospital, Seoul, Korea. 2Department of Orthopedic Surgery, Seoul Chuk Hospital, Seoul, Korea. *Corresponding author: Jong Yoon Lee, M.D. Department of Neurology, Seoul Chuk Hospital, 8, Dongsomun-ro 47-gil Seongbuk-gu Seoul, Republic of Korea, Tel: + 82-1599-0033; E-mail: [email protected] Received date: June 13, 2020; Accepted date: August 21, 2020; Published date: August 28, 2020 Citation: Lee JY, Ha HC, Mo NJ, Ho HK (2020) Relationship Between the Postoperative Delirium and Dementia in Elderly Surgical Patients: Alzheimer’s Disease or Vascular Dementia Relevant Study. J Neurol Neurosci Vol.11 No.5: 332. gender and CRP value {HTN, 42.90% vs. 43.60%: DM, 45.50% vs. 33.30%: female, 27.2% of 63.0 vs. male 13.8% Abstract of 32.0}. Background: Delirium is common in elderly surgical Conclusion: Dementia play a key role in the predisposing patients and the etiologies of delirium are multifactorial. factor of POD in elderly patients, but found no clinical Dementia is an important risk factor for delirium. This difference between two subgroups. It is estimated that study was conducted to investigate the clinical relevance AD and VaD would share the pathophysiology, two of surgery to the dementia in Alzheimer’s disease (AD) or subtype dementia consequently makes a similar Vascular dementia (VaD). -
Vascular Dementia Vascular Dementia
Vascular Dementia Vascular Dementia Other Dementias This information sheet provides an overview of a type of dementia known as vascular dementia. In this information sheet you will find: • An overview of vascular dementia • Types and symptoms of vascular dementia • Risk factors that can put someone at risk of developing vascular dementia • Information on how vascular dementia is diagnosed and treated • Information on how someone living with vascular dementia can maintain their quality of life • Other useful resources What is dementia? Dementia is an overall term for a set of symptoms that is caused by disorders affecting the brain. Someone with dementia may find it difficult to remember things, find the right words, and solve problems, all of which interfere with daily activities. A person with dementia may also experience changes in mood or behaviour. As the dementia progresses, the person will have difficulties completing even basic tasks such as getting dressed and eating. Alzheimer’s disease and vascular dementia are two common types of dementia. It is very common for vascular dementia and Alzheimer’s disease to occur together. This is called “mixed dementia.” What is vascular dementia?1 Vascular dementia is a type of dementia caused by damage to the brain from lack of blood flow or from bleeding in the brain. For our brain to function properly, it needs a constant supply of blood through a network of blood vessels called the brain vascular system. When the blood vessels are blocked, or when they bleed, oxygen and nutrients are prevented from reaching cells in the brain. As a result, the affected cells can die. -
Neurocognitive and Functional Impairment in Adult and Paediatric Tuberculous Meningitis [Version 1; Peer Review: 2 Approved]
Wellcome Open Research 2019, 4:178 Last updated: 20 MAY 2021 REVIEW Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis [version 1; peer review: 2 approved] Angharad G. Davis 1-3, Sam Nightingale4, Priscilla E. Springer 5, Regan Solomons 5, Ana Arenivas6,7, Robert J. Wilkinson 2,8,9, Suzanne T. Anderson10,11*, Felicia C. Chow 12*, Tuberculous Meningitis International Research Consortium 1University College London, Gower Street, London, WC1E 6BT, UK 2Francis Crick Institute, Midland Road, London, NW1 1AT, UK 3Institute of Infectious Diseases and Molecular Medicine. Department of Medicine, University of Cape Town, Observatory, 7925, South Africa 4HIV Mental Health Research Unit, University of Cape Town,, Observatory, 7925, South Africa 5Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa 6The Institute for Rehabilitation and Research Memorial Hermann, Department of Rehabilitation Psychology and Neuropsychology,, Houston, Texas, USA 7Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas, USA 8Department of Infectious Diseases, Imperial College London, London, W2 1PG, UK 9Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Diseases and Molecular Medicine at Department of Medicine, University of Cape Town, Observatory, 7925, South Africa 10MRC Clinical Trials Unit at UCL, University College London, London, WC1E 6BT, UK 11Evelina Community, Guys and St Thomas’ -
A Patient's Guide to Parkinson's Disease Dementia (PDD)
A Patient’s Guide to Parkinson’s Disease Dementia (PDD) This material is provided by UCSF Weill Institute for Neurosciences as an educational resource for patients. Models for illustrative purposes only. A patient’s guide to Parkinson’s Disease Dementia (PDD) What is dementia? eventually parts of the brain that are important for mental functions such as memory and thinking become injured. Dementia is a general term for any disease that causes a change in memory and/or thinking skills that is severe enough to impair How is age related to PDD? a person’s daily functioning. Symptoms of dementia vary from Both PD and PDD are more common with increasing age. Most person to person and may affect one’s ability to remember things, people with PD start having movement symptoms between ages concentrate, plan and organize, communicate or find one’s way 50 and 85, although some people have shown signs earlier. Up to around, among other possible symptoms. There are many causes 80% of people with PD eventually develop dementia. The average of dementia and Parkinson’s disease can be one of them. Not at all time from onset of movement problems to development people with Parkinson’s disease develop dementia. of dementia is about 10 years. What is Parkinson’s disease dementia? What happens in PDD? Parkinson’s disease dementia (PDD) is changes in thinking and People with PDD may have trouble focusing, remembering things, behavior in someone with a diagnosis of Parkinson’s disease (PD). or making sound judgments. They may develop depression, anxiety PD is an illness characterized by gradually progressive problems or irritability. -
Use of Neurotechnology in Normal Brain Aging and Alzheimer
Use of Neurotechnology in Normal Brain Aging and Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) NIA Virtual Workshop Division of Neuroscience April 27, 2020 Final June 1, 2020 This meeting summary was prepared by Dave Frankowski, Rose Li and Associates, Inc., under contract to the National Institute on Aging (NIA). The views expressed in this document reflect both individual and collective opinions of the focus group participants an d not necessarily those of NIA. Review of earlier versions of this meeting summary by the following individuals is gratefully acknowledged: Ali Abedi, Ed Boyden, Dana Carluccio, Monica Fabiani, Mariana Figueiro, Jay Gupta, Ben Hampstead, Marie Hayes, Abhishek Rege, Fiza Singh, Nancy Tuvesson, Shuai Xu. Neurotechnology in Normal Brain Aging, AD, and ADRD April 27, 2020 Table of Contents Executive Summary ............................................................................................................... 1 Meeting Summary ................................................................................................................. 3 Welcome and Opening Remarks .............................................................................................................. 3 Using Non-invasive Sensory Stimulation to Ameliorate Alzheimer’s Disease Pathology and Symptoms 3 Flipping the Switch: How to Use Light to Improve the Lives and Health of Persons with Alzheimer’s Disease and Related Dementias .............................................................................................................. -
Behavioral and Emotional Disorders in Children and Their Anesthetic Implications
children Review Behavioral and Emotional Disorders in Children and Their Anesthetic Implications Srijaya K. Reddy 1,* and Nina Deutsch 2 1 Department of Anesthesiology, Division of Pediatric Anesthesiology—Monroe Carell Jr. Children’s Hospital, Vanderbilt University Medical Center, 2200 Children’s Way Suite 3116, Nashville, TN 37232, USA 2 Division of Anesthesiology, Pain and Perioperative Medicine—Children’s National Hospital, The George Washington University School of Medicine and Health Sciences, 111 Michigan Avenue NW, Washington, DC 20010, USA; [email protected] * Correspondence: [email protected]; Tel.: +01-(615)-936-0023 Received: 16 October 2020; Accepted: 21 November 2020; Published: 25 November 2020 Abstract: While most children have anxiety and fears in the hospital environment, especially prior to having surgery, there are several common behavioral and emotional disorders in children that can pose a challenge in the perioperative setting. These include anxiety, depression, oppositional defiant disorder, conduct disorder, attention deficit hyperactivity disorder, obsessive compulsive disorder, post-traumatic stress disorder, and autism spectrum disorder. The aim of this review article is to provide a brief overview of each disorder, explore the impact on anesthesia and perioperative care, and highlight some management techniques that can be used to facilitate a smooth perioperative course. Keywords: child behavioral disorders; attention deficit and disruptive behavior disorders; perioperative care; anesthesia; autism spectrum disorder; premedication; emergence delirium 1. Introduction Anxiety and fear are common emotions for children to experience when faced with the need to undergo a surgical or diagnostic procedure, with Kain and colleagues determining that up to 60% of all children undergoing anesthesia and surgery report significant anxiety [1]. -
Cognitive Impairment/Dementia – Summary
Cognitive Impairment/Dementia Care Guide December 2014 SUMMARY GOALS Early identification of affected patients Prevention of victimization Reduce symptom severity Improve quality of life ALERTS Victimized patients Increase in rules violation behaviors Worsening personal hygiene Anxiety and agitation, especially at night Complete Advance Directive-Durable Power of Attorney for Health Care (DPAHC) early in course of disease Prison environment may mask symptoms DIAGNOSTIC CRITERIA/EVALUATION Definition - Mild Cognitive Impairment (MCI) Cognitive decline greater than expected for age and education level without significantly interfering with activities of daily life. Evidence of memory impairment Preservation of general cognitive and functional abilities Absence of diagnosed dementia Definition - Dementia Cognitive impairment with: significant decline from previous level of performance in one or more cognitive domains (complex attention, executive function, learning and memory, language, social cognition, perceptual motor) interference with independence in daily activities Not occurring exclusively with delirium Not better explained by another disorder Neurobehavioral abnormalities History - MCI and Dementia patients may have similar historical findings which contribute to the ultimate diagnosis: Poor adherence to rules and routines Personal hygiene problems Impaired comprehension History of head injury, substance abuse, or other medical contributors Differential Diagnosis – Mild Cognitive Impairment (MCI) Medication -
Mild Cognitive Impairment Or Dementia
What To Know When You Have Mild Cognitive Impairment or Dementia People who are told they have mild cognitive impairment (MCI) experience symptoms that are similar to dementia, but aren’t as serious. People with MCI have changes in memory or thinking typically poorer than would be expected for someone their age, but the changes don’t interfere with daily activities. It should be noted that people with MCI have a higher risk of developing dementia, but not all will. Dementia is an umbrella term to describe symptoms that are severe enough to interfere with daily activities. The most common cause of dementia in older adults is Alzheimer’s disease. Other causes include Lewy body dementia, vascular dementia and Frontotemporal diseases. A diagnosis of Alzheimer’s disease or a related disorder doesn’t change who you are and it doesn’t mean you need to stop doing things you find meaningful. It does mean that over time you might have to do them in a different way or have some assistance. The disease does not affect the entire brain all at once. Many areas of the brain are not affected, or are affected much later. Important Messages Dementia can affect memory, We All Should Know thinking, communication and doing everyday tasks. Dementia is not a natural part of aging. It’s possible to live well with dementia. Dementia is caused by diseases of the brain and will There is more to a person affect each person differently. than the dementia. Ways to Work With Mild Cognitive Impairment or Dementia 1 6 Stop multi-tasking. -
The Cognitive Basis of Dyslexia in School-Aged Children: a Multiple Case
The cognitive basis of dyslexia The cognitive basis of dyslexia in school-aged children: a multiple case study in a transparent orthography Agnieszka Dębska1*, Magdalena Łuniewska1,2*, Julian Zubek2, Katarzyna Chyl1, Agnieszka Dynak1,2, Gabriela Dzięgiel-Fivet1, Joanna Plewko1, Katarzyna Jednoróg1, Anna Grabowska3 * these authors contributed equally to the paper 1Laboratory of Language Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland 2 Faculty of Psychology, University of Warsaw, Warsaw, Poland 3Faculty of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland Laboratory of Language Neurobiology Nencki Institute of Experimental Biology, Polish Academy of Sciences ul. Pasteura 3, 02-093 Warszawa, Poland Conflict of Interest Statement None of the authors has to declare a conflict of interest. Supplementary materials 1. Tables and Figures 2. Supplementary materials S1, S2, S3 and S4 1 The cognitive basis of dyslexia The cognitive basis of dyslexia in school-aged children: a multiple case study in a transparent orthography Research highlights ● This study tested the (co)existence of cognitive deficits in dyslexia in phonological awareness, rapid naming, visual and selective attention, auditory skills, and implicit learning. ● The most frequent deficits in Polish children with dyslexia included a phonological (51%) and a rapid naming deficit (26%), which coexisted in 14% of children. ● Despite the severe reading impairment, 26% of children with dyslexia presented no deficits in measured cognitive abilities. ● RAN explains reading skills variability across the whole spectrum of reading ability; phonological skills explain variability best among average and good readers but not poor readers. Abstract This study focused on the role of numerous cognitive skills such as phonological awareness (PA), rapid automatized naming (RAN), visual and selective attention, auditory skills, and implicit learning in developmental dyslexia.