(Appendix 1)

List of Principal Investigators

Academic Current affiliation degree and Name Age (organization, Notes current department) specialties University of Tsukuba, M.D.,Ph.D. International Institute for 1 Masashi Yanagisawa* 52 , Integrative Sleep Pharmacology Medicine University of Tsukuba, International Institute for M.D.,Ph.D. 2 Hiromasa Funato* 43 Integrative Sleep Neuroscience Medicine Kanazawa University, Department of M.D.,Ph.D. 3 Takeshi Sakurai* 48 By the end of 2012 and Neuroscience Neuroscience Osaka Bioscience Ph.D. Institute, Department of 4 Yoshihiro Urade* 59 Neuroscience, By October 2013 Molecular Behavioral University of Texas Southwestern Medical M.D,Ph.D. 5 Robert Greene* 62 By October 2013 Center, Neuroscience Department of Psychiatry University of Texas Ph.D. Southwestern Medical 6 Qinghua Liu* 41 Biochemistry By October 2013 Center,Department of Biochemistry University of Kitasato, Ph.D. Department of Medicinal Medicinal 7 Hiroshi Nagase* 65 Chemistry and School of By October 2013 Pharmacy Chemistry

M.D,Ph.D. University of Tsukuba, Occupational 8 Ichiyo Matsuzaki* 52 Faculty of Medicine Psychiatric Medicine, Space Medicine

M.D.,Ph.D. University of Tsukuba, 9 Hitoshi Shimano* 51 Endocrinology, Faculty of Medicine

University of Tsukuba, Ph.D. 10 Junichi Hayashi* 63 Faculty of Life and Biology Environmental Sciences

（Host institution：University of Tsukuba Center name：International Institute for Integrative Sleep Medicine） 1 (Appendix 1)

List of Principal Investigators

Academic Current affiliation degree and Name Age (organization, Notes current department) specialties

University of Tsukuba, Ph.D. 11 Akiyoshi Fukamizu* 53 Faculty of Life and Molecular Environmental Sciences Biology

M.D.,Ph.D. Uiversity of Tsukuba, 12 Satoru Takahashi* 51 Developmental Faculty of Medicine biology

Akita University Graduate School of Medicine, M.D.,Ph.D. 13 Tetsuo Shimizu* 59 satellite Department of Psychiatry Neuropsychiatry University of Texas Southwestern Medical Ph.D. 14 Carla Green* 50 satellite (overseas) Center, Department of Neuroscience Neuroscience University of Texas Southwestern Medicinal Ph.D. 15 * 61 satellite (overseas) Center, Molecular Neuroscience Neurobiology and Genetics

（Host institution：University of Tsukuba Center name：International Institute for Integrative Sleep Medicine） 2