ERC Activities and Achievements in 2019
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Three Dimensions of Individualized Nanomedicine by Mauro Ferrari
Texas A&M University Nano/Micro Seminar Series Presents: Three Dimensions of Individualized Nanomedicine by Mauro Ferrari Friday, September 11, 1 p.m. – 2 p.m. Room 103, Zachry Engineering Center (ZEC) Abstract: In judicious integration with the biological and clinical disciplines, nanomedicine offers un- precedented opportunities for the individualization of prevention, screening, diagnostics and therapy. The fundamental queries in individualized medical therapy pertain to the delivery of the “right” bioactive agents at the “right” place, with the “right” time profile, triggering the “right” interactions with the target biology, and in a manner that allows for the monitoring for the therapeutic efficacy and undesired effects, as rapidly as possible. In this talk I will review these challenges and the efforts to address them in our laboratory, using a combination of silicon nanotechnology, molecular biology, mathematics and multiple engineering disciplines. The four technology platforms I will present are: MultiStage Vectors (MSV) for intravascular injection; Nanostructured surfaces (nanochips) for proteomic and peptidomic profiling from biological fluids; the space-bound nanochannel Delivery Systems (nDS) for controlled release from implants; and our ‘baby’, the BioNanoScaffolds (BNS) for Post-Traumatic OsteoRegeneration. Biography: Dr. Mauro Ferrari serves as a professor & director of the Center for NanoMedicine, Brown Foun- dation Institute of Molecular Medicine, chairman in the Department of Biomedical Engineering, University of Texas Health Science Center at Houston, Professor of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Professor of Bioengineering, Rice University and President of the Alliance for NanoHealth, Houston TX. Ferrari received a Ph.D. in mechanical engineering from U.C. Berkeley. -
Comparison of Multiresolution Features for Texture Classification
130 IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE, VOL. 15, NO. 1, JANUARY 2011 Comparison of Multiresolution Features for Texture Classification of Carotid Atherosclerosis From B-Mode Ultrasound Nikolaos N. Tsiaparas, Spyretta Golemati, Member, IEEE, Ioannis Andreadis, John S. Stoitsis, Member, IEEE, Ioannis Valavanis, Member, IEEE, and Konstantina S. Nikita, Senior Member, IEEE Abstract—In this paper, a multiresolution approach is sug- The spatial distribution of gray levels in a plaque ultrasound gested for texture classification of atherosclerotic tissue from image, estimated using texture, is determined by the distribu- B-mode ultrasound. Four decomposition schemes, namely, the dis- tion of echogenic (fibrous and calcified tissue) and anechoic crete wavelet transform, the stationary wavelet transform, wavelet packets (WP), and Gabor transform (GT), as well as several basis (blood and lipids) materials within the plaque. Such distribu- functions, were investigated in terms of their ability to discrim- tions may be characterized by 1) low frequencies, i.e., slow inate between symptomatic and asymptomatic cases. The mean changes in gray levels; these may correspond to large areas oc- and standard deviation of the detail subimages produced for each cupied by a specific type material; or 2) high frequencies, i.e., decomposition scheme were used as texture features. Feature selec- rapid changes in gray levels; these may correspond to differ- tion included 1) ranking the features in terms of their divergence values and 2) appropriately thresholding by a nonlinear correlation ent materials randomly scattered within the plaque. In reality, coefficient. The selected features were subsequently input into two however, texture measures describe not only the underlying ma- classifiers using support vector machines (SVM) and probabilistic terial distribution but also the effect of speckle that is due to the neural networks. -
Toward Novel Noninvasive and Low-Cost Markers For
652 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 60, NO. 3, MARCH 2013 Toward Novel Noninvasive and Low-Cost Markers for Predicting Strokes in Asymptomatic Carotid Atherosclerosis: The Role of Ultrasound Image Analysis Spyretta Golemati, Member, IEEE, Aimilia Gastounioti, Student Member, IEEE, and Konstantina S. Nikita∗, Senior Member, IEEE Abstract—Stroke is a serious and frequent cerebrovascular dis- the brain. Of the 15 million people suffering a stroke annually, ease with an enormous socioeconomic burden worldwide. Stroke 5 million die and another 5 million are left permanently disabled, prevention includes treatment of carotid atherosclerosis, the most placing a burden on family and community [1]. Reported preva- common underlying cause of stroke, according to a specific diag- nostic algorithm. However, this diagnostic algorithm has proved lence rates range from 5% in subjects aged less than 75 years to insufficient for a large number of mostly asymptomatic subjects, 10% or more in subjects aged more than 80 years in Europe [2] which poses a significant research challenge of identifying novel and are about 3% in the USA [3]. Projections show a 24.9% personalized risk markers for the disease. This paper illustrates increase in prevalence from 2010, by 2030 [3]. Stroke burden the potential of carotid ultrasound image analysis toward this di- is projected to rise from around 38 million disability-adjusted rection, with ultrasound imaging being a low-cost and noninva- sive imaging modality and ultrasound-image-based features re- life years (DALYs) globally in 1990 to 61 million DALYs in vealing valuable information on plaque composition and stability. 2020 [1]. Although the incidence of stroke is declining in high- A concise report of state-of-the-art studies in the field is provided income countries, it is increasing in middle- and low-income and a perspective for clinical scenario for optimal management countries [4]; furthermore, the absolute number of strokes con- of atherosclerotic patients is described. -
Commission Appoints Mauro Ferrari As Next President of the European Research Council
European Commission - Press release Commission appoints Mauro Ferrari as next President of the European Research Council Brussels, 14 May 2019 The European Commission has today appointed Professor Mauro Ferrari as the next President of the European Research Council (ERC), responsible for funding investigator- driven frontier scientific research in Europe. Professor Ferrari will take up his new role as of 1 January 2020, when the mandate of current President Professor Jean-Pierre Bourguignon ends. The new President joins the ERC at an important moment for its development. For the next long-term EU budget, the Commission has proposed Horizon Europe, the most ambitious EU research and innovation programme ever. A political agreement on the new programme was reached in April. Horizon Europe will safeguard the independence of the ERC under the Scientific Council and maintain its sole focus on scientific excellence. The Commission has proposed a significant budget increase for the ERC from €13.1 billion in 2014-2020 to €16.6 billion for 2021-2027. Carlos Moedas Commissioner for Research, Science and Innovation, said: "The ERC has a global reputation for funding excellent, curiosity-driven research. Professor Mauro Ferrari is internationally renowned for his outstanding interdisciplinary academic career. With his understanding of the societal value of science, his strong leadership and exceptional communication skills, Prof. Ferrari is the right person to take the ERC and European science to new heights. I would also like to pay tribute to President Jean-Pierre Bourguignon, who has led the ERC from strength to strength." Professor Ferrari, incoming President of the European Research Council, added: “It is an honour to have been chosen to serve as the next President of the European Research Council. -
Nanotechnologynanotechnology Forfor Cancercancer Medicinemedicine Andand Researchresearch
NanotechnologyNanotechnology forfor CancerCancer MedicineMedicine andand ResearchResearch MauroMauro Ferrari,Ferrari, Ph.D.Ph.D. Professor,Professor, BrownBrown InstituteInstitute ofof MolecularMolecular MedicineMedicine ProfessorProfessor ofof InternalInternal MedicineMedicine Chairman,Chairman, BiomedicalBiomedical EngineeringEngineering UniversityUniversity ofof TexasTexas HealthHealth SciencesSciences Center,Center, HoustonHouston Professor,Professor, ExperimentalExperimental Therapeutics,Therapeutics, MDMD AndersonAnderson Professor,Professor, Bioengineering,Bioengineering, RiceRice UniversityUniversity President,President, AllianceAlliance forfor NanoHealthNanoHealth CERN – June 12, 2007 NanotechnologyNanotechnology inin PerspectivePerspective Water Glucose Antibody Virus Bacteria Cancer cell A period Tennis ball 10-1 11010 2 103 104 105 106 107 108 Nanometers Nanodevices: Nanopores Dendrimers Nanotubes Quantum dots Nanoshells NanotechnologiesNanotechnologies WhatWhat isis thethe AllianceAlliance forfor NanoHealth?NanoHealth? ConsortiumConsortium ofof sevenseven institutionsinstitutions governedgoverned byby memorandummemorandum ofof understandingunderstanding ofof 12/16/2004.12/16/2004. VirtualVirtual collectioncollection ofof 500+500+ investigatorsinvestigators MechanismMechanism forfor funding:funding: aaSharedShared infrastructureinfrastructure aaCollaborativeCollaborative researchresearch aaConferences/workshopsConferences/workshops aaStudentStudent programsprograms Office: The Fayez S. Sarofim Research Building (IMM) 537 -
Nanotechnology the Translation of Nanotechnology-Based Therapies and Products from the Laboratory to the Clinic Requires a Multidisciplinary Approach
CAREER SNAPSHOTS Nanotechnology The translation of nanotechnology-based therapies and products from the laboratory to the clinic requires a multidisciplinary approach. Our two interviewees this month discuss their roles in bringing together diverse groups of scientists to achieve this goal. Following his Ph.D. in mechanical engineering institutions, and we have a formal and unique Mauro Ferrari, Ph.D. at the University of California, Berkeley partnership with the FDA on nanomedicine.” University Endowed (UC Berkeley), USA, Ferrari took faculty positions in Ferrari is also a tenured professor of Chair in Biomedical materials science and engineering, as well as civil experimental therapeutics at the M.D. Engineering, Professor engineering, at UC Berkeley in 1991. His research Anderson Cancer Center, and an adjunct and Chair, Department interests expanded into bioengineering in 1994, professor of bioengineering at Rice University of Nanomedicine and and by 1996 he was a tenured faculty member and the University of Texas in Austin. For all of the Biomedical Engineering, and the director of the Biomedical Microdevices positions he has held and currently holds, Ferrari and Professor of Internal Medicine, Center at UC Berkeley. “I left UC Berkeley to has been driven by what he calls ‘medical pull’ The University of Texas Health Science become full professor of medicine and department — developing technological solutions by seeing Center, Houston, Texas, USA. director at Ohio State University (OSU), where I the unmet need from the medical perspective. also went to medical school,” says Ferrari. “Many technologists look for applications for the In September 2009, Mauro Ferrari became While at OSU, Ferrari also directed the technologies that they have developed, but this the founding chairman of the Department of development of the National Cancer Institute’s is rarely successful,” he explains. -
Ketonemia and Ketonuria in Gestational Diabetes Mellitus
HORMONES 2015, 14(4):644-650 Research paper Ketonemia and ketonuria in gestational diabetes mellitus Loukia Spanou,1 Kalliopi Dalakleidi,2 Konstantia Zarkogianni,2 Anastasia Papadimitriou,1 Konstantina Nikita,2 Vasiliki Vasileiou,1 Maria Alevizaki,1 Eleni Anastasiou1 1Diabetes Center, 1st Endocrine Section, Alexandra General Hospital, Athens; 2Faculty of Electrical and Computer Engineering, National Technical University of Athens, Athens; Greece ABSTRACT %$&.*5281'7KHXVHRIFDSLOODU\EORRGȕK\GUR[\EXW\UDWH +% LVDPRUHSUHFLVH method than urine ketones measurement for the diagnosis of diabetic ketoacidosis. Fasting ketonuria is common during normal pregnancy, while there is evidence that it is increased among pregnant women with Gestational Diabetes Mellitus (GDM) who are on a diet. 3HB levels have been related to impaired offspring psychomotor development. Reports with concomitant measurement of blood and urine ketones in women with GDM who followed a balanced diet are lacking. OBJECTIVE: To compare the prevalence of fasting ketonemia and ketonuria in women with GDM following the Institute of Medicine diet instructions and assess their possible relation with metabolic parameters and therapeutic interventions. RESEARCH DESIGN AND METHODS: 180 women with GDM were studied. In each patient, in successive visits, capillary blood and urine ketones were simultaneously measured. The total measurements were 378, while the average number of measurements per patient was 2.1. RESULTS: The prevalence of ketonuria was significantly higher than that of ketonemia (x2=21.33, p <0.001). Significantly higher mean 3HB levels were observed with respect to ketonuria severity (p=0.001). Bedtime carbohydrate intake was associated with significantly lower 3HB levels (p=0.035). Insulin treatment was associated with significant 3HB levels reduction (p=0.032). -
CVII-STENT 2014 Program Final
The Joint MICCAI-Workshops on Computing and Visualization for Intravascular Imaging and Computer Assisted Stenting (CVII-STENT) 2014 Sunday 14 September 2014 Stata Center, Building 32, Room 144, MIT Campus Program 0700 Coffee and Registration 0815 Welcome 0820 Oral Session: Visualisation and Enhancement Chairs: Su-Lin Lee and Simone Balocco Volume Constraint Denoising of Digital Subtraction Angiography Sequences Richard Brosig*1; Markus Kowarschik2, Nassir Navab1, Maximilian Baust1 1Technical University Munich, Germany 2Siemens Healthcare, Germany Blob enhancement filter for computer-aided diagnosis of cerebral aneurysms Tim Jerman*, Žiga Špiclin, Boštjan Likar, Franjo Pernuš University of Ljubljana, Slovenia X-ray depth maps - Towards improved interventional visualization and beyond Wang Xiang1,2, Christian Schulte zu Berge1, Pascal Fallavollita1, Nassir Navab1, Stefanie Demirci1* 1Technical University Munich, Germany 2Beihang University, China 0920 Oral Session: Intravascular Imaging Part I Chairs: Amin Katouzian and Maria A. Zuluaga Quantitative comparison of plaque in coronary culprit and non-culprit vessel segments using intravascular ultrasound Zhi Chen*1, Andreas Wahl1, Richard Downe1, Shanhui Sun1, Tomas Kovarnik2, John Lopez3, Milan Sonka1 1University of Iowa, US 2Charles University, Prague, Czech Republic 3Loyola University Stritch School of Medicine, US 1 Fully automated detection of healthy wall sections in intracoronary optical coherence tomography Guillaume Zahnd*, Antonios Karanasos, Gijs van Soest, Evelyn Regar, Wiro Niessen, -
Annual Report
Zilkha Neurogenetic Institute 2013-2014 annual report Table of Contents 2 Director’s Letter 3 History and Mission 4 ZNI Faculty 8 Faculty Research Programs 12 Scientific Advancements 23 Collaborations 37 Faculty News 41 Faculty Activities 43 Grants and Contracts 50 Special Lectures 51 4th Annual Zach Hall Lecture 52 1st Annual Zilkha Symposium on Alzheimer’s Disease & Related Disorders 54 Academic Activities 56 Neurodegeneration Journal Club/NRSA Grant Training 57 Los Angeles Brain Bee 58 Music to Remember - LA Opera/Alzheimer’s Association 59 ZNI Graduate Students 62 ZNI Postdoctoral Trainees 64 FY14 Faculty Publications 81 ZNI Administration 83 ZNI Development 1 Dear Friends, The World Health Organization estimates that devastating brain disorders and diseases affect more than one billion people worldwide. Last year, President Obama launched the BRAIN Initiative as a large-scale effort to equip researchers with fundamental insights necessary for treating a wide variety of brain disorders like Alzheimer’s, schizophrenia, autism, epilepsy, and traumatic brain injury. Research on the brain is surging. The United States and the European Union have launched new programs to better understand the brain. Scientists are mapping parts of mouse, fly and human brains at different levels of magnification. Technology for recording and imaging brain activity has been improving at a revolutionary pace. Yet the growing body of data—maps, atlases and so-called connectomes that show linkages between cells and regions of the brain— represents a paradox of progress, with the advances also highlighting great gaps in understanding. Specifically, interpreting these brain-wiring maps, and ultimately establishing the approach that physicians and scientists will use to treat neurological diseases, requires a clear understanding of brain circuitry, information that can only be obtained through basic research like the fine work being performed at ZNI. -
The Complexity of Cancer As a Disease, the Challenges of Coordinating
MIT Faculty Club Applying Nanotechnology to Medicine Dr. Mauro Ferrari on biotechnology and cancer treatment. To many, nanotechnology is viewed simply as development, refinement and application of a “small scale” technology that will someday biomedical nanotechnology. change the world. They would be surprised to know that the technology arrived long ago, Dr. Ferrari grew up in Udine, the capital of and that it has already changed our lives in Friuli, in the northeast corner of Italy close to ways we don’t fully appreciate. In fact, one Austria and Slovenia. He traced his life research report projects the global market for beginning as a youth who developed passions nanotechnology-based products to exceed for basketball and jazz. He teased the PIB $1.6 trillion by 2013, thanks in no small part audience with the complaint that years later, to its biomedical applications. nobody cares to discuss those erstwhile talents. Subsequently, he trained in mathematics, engineering and medicine, and he has published approximately 200 peer- reviewed articles. The profound impact of his family upon his career decisions became clear when he faced the death of his wife, which was a turning point in his life. Doctors informed him that their inability to treat his wife was primarily a function of not being able to deliver the right drugs to the right place in time to treat her illness. One of the leading authorities of this multi- disciplinary technology is Dr. Mauro Ferrari, PhD, President and CEO, Ernest Cockrell Jr. Distinguished Endowed Chair at The Methodist Hospital Research Institute, and President of the Alliance for NanoHealth, in Houston. -
Nanomedicine: Today and Tomorrow
Nanomedicine: Today and Tomorrow DISTINGUISHED SPEAKERS Mauro Ferrari, Ph.D. (Ohio State University) James Baker, Jr., M.D. (University of Michigan) Guy della Cioppa, Ph.D. (NanoInk, Inc) Uri Sagman, M.D. (C Sixty, Inc) MODERATOR Klaudyne Hong, Ph.D. (Berlex/ScheringAG) VENUE Fairchild auditorium, Stanford University Oct 30, 2003 6:00-9:00 pm SPONSORS www.mitstanfordberkeleynano.org AGENDA 6:00 – 6:50 pm Registration, Refreshments and Networking 7:00 – 7:10 pm Introduction Dr.Wasiq Bokhari, Chair, MI T S tanford UC Berkeley Nanotechnology Forum Dr.Victor Boksha, Co-Director of the event, MIT Stanford UC Berkeley Nanotechnology Forum 7:10 – 8:45 pm Nanomedicine presentations 8:45 – 9:00 pm Q&A session 9:00 pm Session close by the Chair SPEAKER BIOS Mauro Ferrari, Ph.D. Presentation: The cancer nanotechnology plan: a roadmap for deployment of nanotechnology in the fight against cancer Dr. Ferrari is a founder and international leader in the fields of biomedical nano- and micro-technology (bioMEMS), and a pioneer of their applications to medical therapeutics in sectors such as drug delivery, cell transplantation, and tissue engineering. His group was the first to successfully perform the implantation of hybrid chips (biological cells included in immunoprotective silicon microchips) into animal models. Dr. Ferrari accepted his current tenured positions of Professor of Internal Medicine, Professor of Mechanical Engineering, and Director of the Biomedical Engineering Center at The Ohio State University in 1999. He was appointed an Associate Director of the Heart and Lung Institute in 2000. He is the scientific founder and Chairman of the Scientific Advisory Board of iMEDD, Inc (1998-). -
Trying to Cure Lung and Liver Metastases)
My 27 Years of Failure (Trying to Cure Lung and Liver Metastases) Dr. Mauro Ferrari University of St Thomas, Minnesota, United States of America Nanomedicine has been a great success, in research laboratories, and in the clinic, since its emergence in medicine about 25 years ago. Yet, it has not been able to yield a general cure for metastatic disease to lungs and liver - which unfortunately are responsible for the vast majority of cancer deaths. nenomedicine is not alone in this "failure" - all other approaches have similarly failed, to date, including chemotherapy, molecularly targeted biotherapeutics, and immunotherapy. In my talk, I will give an overview of my long and rather colorful list of personal failures in attempting to do just that: To cure visceral metastases, regardless of their primary cancer site of origin. Along the way, I found myself in the early, formative stages of nanomedicine - and we have continued to share the journey until now. Post-nanomedicine I also developed a number of different approaches, which employed nanotechnology as one of the components of the attempted solutions. This gave rise to other fields, such as multi-stage vectors (MSV), transport oncophysics (TOP), and injectable nanoparticle generators (iNPG). A combination of these is now giving me new hope that a cure for metastatic disease to lung and liver for many may actually be reachable, soon. We have developed a new drug, regulatory codename ML-016, (scientific name iNPG-pDox), which has shown unprecedented curative results in preclinical models, and now we are taking it to the clinic. We have developed and scaled up good manufacturing techniques, build a specialized facility, progressed through toxicity studies with exemplary results, and had independent verification of of efficacy results.