Equine Research News A digital presentation of Grayson-Jockey Club Research Foundation Providers of Equine Research From 1940 thru 2016 Issue 9 • 2016

CLASSIC EMPIRE GRADE 1 WINS In this edition: TO BENEFIT EQUINE RESEARCH • Share the Wins for 2017 Begins John C. Oxley, the owner of Breeders’ Cup Juvenile winner , has pledged to Grayson-Jockey • A Review of 2016 Research Club Research Foundation 1% of the owner’s share of any Grade I victories by the colt from now through the • Activities and Updates of the Year Kentucky Derby. • Events of 2016

Oxley owns Fawn Leap Farm in Midway, Ky., and is a board member of Grayson-Jockey Club Research Foundation. In 2001, he made a similar pledge in 2016 RESEARCH FUNDED connection with Monarchos. The colt went on to win the Kentucky Derby, generating a donation of $8,120 Grayson-Jockey Club Research Foundation funded over to the foundation. $1.1 million in 19 equine research projects and two Research Career Development awards. That brings the “We appreciate Mr. Oxley’s making this generous totals of projects funded to more than $23.3 million to pledge,” said Edward L. Bowen, president of Grayson- fund 335 projects at 42 universities in North America Jockey Club Research Foundation. “The precedent of and overseas, since 1983. his having won the Derby with Monarchos is a great memory, and we wish him well again. Owners who The projects: recognize the benefits of scientific research are very important to the entire world of the horse, and • New treatment options and prophylactic training Mr. Oxley exemplifies that echelon of horseman.” methods to prevent or reduce the occurrence of Dorsal Displacement of the Soft Palate in young horses starting training

• A new concept for a vaccine to protect horses against the disease known as Strangles

• Testing Positron Emission Tomography imaging that will allow detection of lesions not identified with other techniques

• Use of an inhaled product applied directly into the lungs to increase immune responses to protect foals against Rhodococcus equi Anne M. Eberhardt photo • Defining the next step to understand underlying mechanisms of disease by developing a database of Classic Empire (---Sambuca Classica, tissue– specific gene expression and regulation in the by ) won the Grade 1 Breeders’ Futurity and healthy adult horse. Grade 3 Bashford Manor prior to his Grade 1 Breeders’ Cup Juvenile score and has a record of four wins from • Determining if drug-resistant Rhodococcus equi can five starts and earnings of $1,485,920. He is trained by persist in the environment and if resistant strains are Mark Casse. more likely to cause disease than susceptible strains.

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• New pain management options that prove more • The potential of anti–inflammatory properties of efficacious and potentially safer firocoxib to significantly inhibit inflammation, and subsequent preterm delivery of foals, from mares with • Validation of a stall–side test that could be used for fast, placentitis sensitive, accurate, and cost efficient diagnosis of strangles • Providing an evidence-based approach to the optimal • Validation of a new test for Rhodococcus equi infections treatment of horses with small intestinal strangulating in foals obstruction in order to reduce endotoxemia and increase survival

• Decreasing the healing time in distal limb wounds with an Injectable hydrogel microsphere scaffolds containing endothelial progenitor cells

• A study to guide the design of devices and/or protocols that can be used in the clinical setting to prevent supporting limb laminitis.

• Risk for bone fracture in the fetlock joint due to training program and race surface properties using • EHV–1 latency locations; and latency stages exist to computer models that simulate bone damage and repair speculate on interventional strategies

• Use of a guinea pig model of R. equi pneumonia to understand the disease in foals, and evaluate a novel approach for controlling and preventing R. equi pneumonia

• Evaluation whether allogeneic mesenchymal stem cells derived from bone marrow (BMDMSCs) are a viable alternative to autologous BMDMSCs in the horse.

Two Career Development Awards offered through the Foundation in 2016.

The Career Development Award, inaugurated in 2006, is a $15,000 grant designed as an early boost to an individual considering a career in equine research. It has been underwritten annually by Mrs. Lucy Young Hamilton, a Grayson-Jockey Club Research Foundation board member whose family stood the retired champion stallion Storm Cat at Overbrook Farm.

The Elaine Klein Development Award is a competitive program intended to promote development of promising • Reviewing stress hormones as well as hormones that investigators by providing a one year salary supplement affect neurological function in the development and of $15,000. This program is restricted to one award per progression of diseases of newborn foals year and is named in honor of renowned horsewoman Elaine Klein. • Exploration of the mechanism of equine herpesvirus-1 blockage of an immune defense pathway and its relation- ship to equine herpesviral myeloencephalopathy Equine Research News Issue 9 • 2016 • page 3

2016 DERBY PLEDGES OCALA INITIATIVE The Foundation was pleased to have several owners with In 2016 the Ocala Initiative began, working with horses on the Derby Trail participate in our special Share organizations in the equine community in Ocala and the Wins program. Heaven Trees, John Oxley, Speedway throughout Florida to raise $100,000; soliciting matching Stables and Xpress Thoroughbreds were among owners funds from individuals. The funds will be earmarked to who pledged 1 percent of net purses (minus entry fees support equine research at the University of Florida. and trainer and jockey fees) for graded stakes up to and To date the following have pledged or donated to help meet including the Kentucky Derby to Grayson-Jockey Club that goal: Double Diamond Farm, Florida Thoroughbred Research Foundation. The Foundation plans a second Breeders and Owners Association, Glen Hill Farm, Derby Trail pledge drive in 2017. Additional information Gulfstream Park , Niall Brennan Stables, Ocala Breeders' about the Share the Wins program is available at Sales, Ocala Stud, Payton Training Center, and Tampa http://tinyurl.com/http-gjcrfstw1. Bay Downs.

OBITUARY WELFARE AND SAFETY OF THE The Foundation lost two board members in 2016. RACEHORSE SUMMIT VII The seventh Welfare and Safety of the Racehorse Summit Ogden Mills (Dinny) Phipps 75, Chairman of The Jockey was held June 28th at the Keeneland Sales Pavilion in Club and a board member of the Foundation, was Lexington, Ky., following 12 reports on topics ranging remembered by the Honorable Earle Mack as “the from racing surfaces, equine injuries and rider safety to pinnacle of leadership, who fought every step as an nutrition, biosecurity, and respiratory health for horses. advocate for the health of the horse and integrity of racing.” Mack made a donation of $100,000 for research in his Emceed by Donna Barton Brothers, former jockey and childhood friend’s memory, suggesting others follow current NBC racing analyst who serves on the advisory his lead. board for the Thoroughbred Aftercare Alliance, the summit is organized and underwritten by Grayson-Jockey Club William Backer, the renowned advertising innovator had Research Foundation and The Jockey Club. It drew been a member of the Grayson-Jockey Club Research approximately 200 observers as well as an international Foundation board of directors since 1997. His efforts on audience who watched a live video stream. behalf of equine research reflected a long-held devotion to the horse, as a breeder and owner of Thoroughbreds as A video replay of the summit, as well as, several of the well as an avid figure in the Virginia hunt fields. presentations are available at http://tinyurl.com/hdaraj7.

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MEMBERSHIP LEVELS (Check one) ANNUAL CONTRIBUTION ADDRESS______ROKEBY CIRCLE $10,000 or more CITY/STATE/ZIP______Platinum Circle $ 7,500 or more ____ Gold Circle $ 5,000 or more TELEPHONE______Silver Circle $ 2,000 or more ____ Patron $ 1,000 or more Email ______Supporting Member $ 500 or more RETURN TO: ____ Sustaining Member $ 200 or more ____ Annual Member $ 100 or more Edward L. Bowen, President I do not wish to be a member Grayson-Jockey Club Research Foundation, Inc. at this time, but choose to donate $______821 CORPORATE DRIVE LEXINGTON, KY 40503 to the Foundation. (859) 224-2850 FAX (859) 224-2853 E-MAIL: [email protected] ____ check/money order enclosed Grayson-Jockey Club Research Foundation is exempt from Federal income tax under section 501 (c) (3) of the Internal Revenue Code of 1986 as ____ please bill me an organization operated exclusively for educational and scientific purposes. Contributions made to the Foundation are deductible by donors in computing their taxable income in the manner and to the extent provided by section 170 of the Code. Equine Research News Issue 9 • 2016 • page 4

EVENTS We wish to thank all of our many sponsors and participants at our various events this year, making 2016 a grand year for the Foundation. Those events included: Belmont Celebration Elizabeth Locke Jewels 2016 Belmont Stakes Charity Celebration (BSCC) honored The Elizabeth Locke Jewels trunk show at Keeneland Thoroughbred owner Stuart Subotnick. The event was was a grand success. Ms. Locke is generous enough to held the Thursday before the Belmont, at the Bryant Park extend that percentage program through Christmas for all Grill in New York City. Located in the heart of New York's sales in which the customer mentions the Foundation. We famed Bryant Park and adjacent to the New York Public thank all who patronized the show. For more information Library, it is one of the country's greatest cultural on the collection visit http://www.elizabethlocke.com. architectural institutions. The venue proved so popular that the 2017 BSCC will be held there as well. Third Annual Grayson-Jockey Club Research Foundation Day at Kentucky Downs Saratoga Golf Sponsorships were sold out for all of the seven races The16th Annual Charity Golf Tournament was held Kentucky Downs made available for the opening day of Tuesday, August 16, 2016 at the Saratoga National Golf racing at Kentucky Downs. The Foundation thanks Club in Saratoga Springs, NY. Our 72 golfers who President Corey Johnsen, for the innovative program participated this year enjoyed a wonderful lunch in Kentucky Downs has offered. The quality of the racing Saratoga National’s course-side tent. Awards were was exceptional and we appreciate all seven of our race presented at a reception at the club house. sponsors for stepping up on behalf of the horse.

Equine Research News is the digital newsletter of the Grayson-Jockey Club Research Foundation 501(c)(3) organization Offices: 821 Corporate Dr, Lexington, KY 40503 40 East 52nd St, New York, NY 10022 http://www.grayson-jockeyclub.org 859-224-2850 • Fax: 859-224-2853 212-371-5970 • Fax: 212-371-6123 Like us on Facebook • Follow us on Twitter