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(12) United States Patent (10) Patent No.: US 9,642,531 B2 Tearney Et Al

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(12) United States Patent (10) Patent No.: US 9,642,531 B2 Tearney Et Al USOO9642531 B2 (12) United States Patent (10) Patent No.: US 9,642,531 B2 Tearney et al. (45) Date of Patent: May 9, 2017 (54) SYSTEMS, METHODS AND (58) Field of Classification Search COMPUTER-ACCESSIBLE MEDIUMWHCH CPC. G01B 9/02091; G02B 27/4205; G02B 6/32: PROVIDE MCROSCOPIC MAGES OF AT A61 B 5/0066: A61 B 5/0044: G06T 5/003 LEAST ONE ANATOMICAL STRUCTUREAT See application file for complete search history. A PARTICULAR RESOLUTION (56) References Cited (71) Applicant: The General Hospital Corporation, U.S. PATENT DOCUMENTS Boston, MA (US) 2,339,754 A 1/1944 Brace (72) Inventors: Guillermo J. Tearney, Cambridge, MA 3,090,753. A 5, 1963 Matuszak et al. (US); Brett Eugene Bouma, Quincy, (Continued) MA (US); Joseph A. Gardecki, Acton, MA (US); Linbo Liu, Cambridge, MA FOREIGN PATENT DOCUMENTS (US) CN 155O2O3 12, 2004 DE 4105221 9, 1991 (73) Assignee: The General Hospital Corporation, Boston, MA (US) (Continued) (*) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS patent is extended or adjusted under 35 Office Action for Japanese Patent Application No. 2012-556286 U.S.C. 154(b) by 53 days. mailed on Sep. 15, 2015. (21) Appl. No.: 14/455,355 (Continued) (22) Filed: Aug. 8, 2014 Primary Examiner — Kara E Geisel Assistant Examiner — Maurice Smith (65) Prior Publication Data (74) Attorney, Agent, or Firm — Andrews Kurth Kenyon US 2015/OO29513 A1 Jan. 29, 2015 LLP (57) ABSTRACT Related U.S. Application Data Exemplary embodiments of systems and methods can be provided which can generate data associated with at least (63) Continuation of application No. 13/042.230, filed on one portion of a sample. For example, at least one first Mar. 7, 2011, now Pat. No. 8,804,126. radiation can be forwarded to the portion through at least one (Continued) optical arrangement. At least one second radiation can be received from the portion which is based on the first radia (51) Int. C. tion. Based on an interaction between the optical arrange G0IB 9/02 (2006.01) ment and the first radiation and/or the second radiation, the A6 IB5/00 (2006.01) optical arrangement can have a first transfer function. Fur GO2B 6/32 (2006.01) ther, it is possible to forward at least one third radiation to (52) U.S. C. the portion through Such optical arrangement (or through CPC .......... A61B 5/0066 (2013.01); A61 B 5/0044 another optical arrangement), and receive at least one fourth (2013.01); A61B 5/0075 (2013.01); radiation from the portion which is based on the third (Continued) (Continued) 570 520 530 550 560 580 500 YaYaNYaYaNYaYa YaxaaSYaYYaYaNYNNSSNSYaNNNa YaYa 510 - smallma sesses SSSSSYYYYYYYY SK)() US 9,642.531 B2 Page 2 radiation. 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