Gilead Sciences to Acquire Kite Pharma for $11.9 Billion
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Jefferies Global Healthcare Conference June 2, 2015 Forward Looking Statements / Safe Harbor
Jefferies Global Healthcare Conference June 2, 2015 Forward Looking Statements / Safe Harbor To the extentstatements contained in this presentation are not descriptionsof historical facts regarding Kite Pharma, Inc. (“Kite,” “we,” “us,” or “our”), they are forward-looking statements reflecting management’s current beliefs and expectations. Forward- looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels or activity, performance, or achievements to be materially different from those anticipated by such statements. You can identify forward-looking statements by words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes. Forward-looking statements contained in this presentation include, but are not limited to, statements regarding: (i) the success, cost and timing of our product development activities and clinical trials; (ii) the ability and willingness of the National Cancer Institute (NCI) to continue research and development activities relating to our product candidates; (iii) our ability to obtain and maintain regulatory approval of KTE-C19 and any other product candidates; (iv) our ability to obtain funding for our operations and further development and commercialization of our product candidates; (v) our plans to research and discover -
Key Metrics for Recent Technology and Life Sciences Initial Public Offerings
H1 2014 Key Metrics for Recent Technology and Life Sciences Initial Public Offerings H1 2014 Key Metrics for Recent Technology and Life Sciences Initial Public Offerings H1 2014 Survey Introduction and Background This report has been developed as a resource for our clients and friends interested in understanding recent IPO activity of technology and life sciences companies. This information comprises a number of graphs and charts reflecting selected statistics that we believe provide useful information about activity in these markets. This is followed by the listing of technology and life sciences IPOs priced in the first half of 2014 and second half of 2013. We hope that you find this useful. Please contact Daniel J. Winnike at [email protected] or Jeffrey R. Vetter at [email protected] if you care to discuss this information or, as always, contact members of your client service team for more information. Survey Contents Survey Results ..................................................................................................................................................... 2 Offerings Completed ............................................................................................................................................. 3 Size of Offerings, Red Herring Midpoint ................................................................................................................. 4 Size of Offerings, Final IPO Price ........................................................................................................................... -
Investment Thesis for Kite Pharma, Inc. (Nasdaq: Kite)
SAF/No.14/March 2017 Studies in Applied Finance INVESTMENT THESIS FOR KITE PHARMA, INC. (NASDAQ: KITE) Samantha Semenkow Johns Hopkins Institute for Applied Economics, Global Health, and the Study of Business Enterprise Investment Thesis for Kite Pharma, Inc. (Nasdaq: KITE) by Samantha Semenkow Investment Thesis for Kite Pharma, Inc. (Nasdaq: KITE) By Samantha Semenkow Disclaimer: These research reports are primarily student reports for academic purposes and are not specific recommendations to buy or sell a stock. Potential investors should consult a qualified investment advisor before making an investment. About the Series The Studies in Applied Finance series is under the direction of Professor Steve H. Hanke ([email protected]), Co-director of The Johns Hopkins Institute for Applied Economics, Global Health, and the Study for Business Enterprise, and Dr. Hesam Motlagh ([email protected]), a Fellow at the Johns Hopkins Institute for Applied Economics, Global Health, and the Study of Business Enterprise. This working paper is one in a series on Applied Financial Economics that focuses on company valuations. The authors are mainly students at The Johns Hopkins University and The Johns Hopkins School of Medicine in Baltimore, MD who have conducted their work at the institute as undergraduate and graduate researchers. About the Author Samantha Semenkow ([email protected]) is a PhD candidate in the Pathobiology Graduate Program at The Johns Hopkins School of Medicine in Baltimore, MD. She conducted the research for this paper while serving as Professor Hanke’s research assistant at The Johns Hopkins Institute for Applied Economics, Global Health, and the Study of Business Enterprise during the Fall of 2016. -
Axelrod V. Kite Pharma, Inc. Et
Case 2:17-cv-06684 Document 1 Filed 09/11/17 Page 1 of 26 Page ID #:1 1 Rosemary M. Rivas (State Bar No. 209147) Email: [email protected] 2 LEVI & KORSINSKY, LLP 44 Montgomery Street, Suite 650 3 San Francisco, California 94104 Telephone: (415) 291-2420 4 Facsimile: (415) 484-1294 5 Counsel for Plaintiff Merry Axelrod 6 7 8 UNITED STATES DISTRICT COURT 9 FOR THE CENTRAL DISTRICT OF CALIFORNIA 10 MERRY AXELROD, individually and on Case No. 2:17-cv-6684 behalf of all others similarly situated, 11 CLASS ACTION Plaintiff, 12 CLASS ACTION COMPLAINT FOR v. VIOLATION OF SECTIONS 14(d)(4), 13 14(e), AND 20(a) OF THE KITE PHARMA, INC., ARIE SECURITIES EXCHANGE ACT OF 14 BELLDEGRUN, DAVID BONDERMAN, 1934 FARAH CHAMPSI, IAN CLARK, ROY 15 DOUMANI, FRANZ HUMER, JOSHUA JURY TRIAL DEMANDED A. KAZAM, RAN NUSSBAUM, JON 16 PEACOCK, STEVEN B. RUCHEFSKY, OWEN N. WITTE, GILEAD SCIENCES, 17 INC., and DODGE MERGER SUB, INC., 18 Defendants. 19 20 Plaintiff Merry Axelrod (“Plaintiff”), by her attorneys, alleges upon information 21 and belief, except for her own acts, which are alleged on knowledge, as follows: 22 INTRODUCTION 23 1. Plaintiff brings this action on behalf of herself and the public stockholders 24 of Kite Pharma, Inc. (“Kite” or the “Company”) against Kite and members of its Board 25 of Directors (collectively, the “Board” or the “Individual Defendants,” as further defined 26 below, and together with the Company “Defendants”) for violations of Section 14(d)(4), 27 15 U.S.C. § 78n(d)(4), of the Securities and Exchange Act of 1934 (the “Exchange Act”), 28 U.S. -
Gene Therapy to Fight a Blood Cancer Succeeds in Major Study Marilynn Marchione, Ap Chief Medical Writer Updated 2:21 Am, Thursday, March 2, 2017
3/10/2017 Gene therapy to fight a blood cancer succeeds in major study - SFGate http://www.sfgate.com/news/medical/article/Gene-therapy-to-fight-a-blood-cancer-succeeds-in-10964727.php Gene therapy to fight a blood cancer succeeds in major study Marilynn Marchione, Ap Chief Medical Writer Updated 2:21 am, Thursday, March 2, 2017 IMAGE 1 OF 2 In this May 2016 photo provided by Kite Pharma, cell therapy specialists at the company's manufacturing facility in El Segundo, Calif., prepare blood cells from a patient to be engineered in the lab to fight ... more An experimental gene therapy that turns a patient's own blood cells into cancer killers worked in a major study, with more than one-third of very sick lymphoma patients showing no sign of disease six months after a single treatment, its maker said Tuesday. In all, 82 percent of patients had their cancer shrink at least by half at some point in the study. Its sponsor, California-based Kite Pharma, is racing Novartis AG to become the first to win approval of the treatment, called CAR-T cell therapy, in the U.S. It could become the nation's first approved gene therapy. A hopeful sign: the number in complete remission at six months — 36 percent — is barely changed from partial results released after three months, suggesting this one-time treatment might give lasting benefits for those who do respond well. "This seems extraordinary ... extremely encouraging," said one independent expert, Dr. Roy Herbst, cancer medicines chief at the Yale Cancer Center. -
For Immediate Release Pfizer Media Contact: April 3, 2018 Jessica Smith (212) 733-6213 [email protected]
For immediate release Pfizer Media Contact: April 3, 2018 Jessica Smith (212) 733-6213 [email protected] Pfizer Investor Contact: Chuck Triano (212) 733-3901 [email protected] Allogene Media/Investor Contact: Christine Cassiano (714) 552-0326 [email protected] Pfizer and Allogene Therapeutics Enter Into Asset Contribution Agreement for Pfizer’s Allogeneic CAR T Immuno-oncology Portfolio Creates alliance with Allogene Therapeutics, a biotechnology company co-founded and led by former executives of Kite Pharma that is positioned to expedite the development of allogeneic CAR T cell therapy Allogene Therapeutics, a Two River portfolio company, was formed with one of the largest Series A financings in biotechnology of $300 million from a premier investment consortium that includes TPG, Vida Ventures, BellCo Capital, the University of California Office of the Chief Investment Officer and Pfizer Pfizer will hold a 25 percent ownership stake in Allogene Therapeutics NEW YORK, N.Y. and South San Francisco, Calif., April 3, 2018 – Pfizer Inc. (NYSE: PFE) and Allogene Therapeutics, Inc. (Allogene) today announced that the two companies have entered into an asset contribution agreement for Pfizer’s portfolio of assets related to allogeneic chimeric antigen receptor T cell (CAR T) therapY, an investigational immune cell therapY approach to treating cancer. Allogene, co-founded and led bY former executives of Kite Pharma, is ideallY positioned to catalYze the development of this allogeneic cell therapY portfolio. Arie Belldegrun, M.D., FACS, Founder and former Chairman, President and Chief Executive Officer of Kite, will serve as Executive Chairman, and David Chang, M.D., Ph.D., former Executive Vice President, Research and Development and Chief Medical Officer of Kite, will serve as President and Chief Executive Officer. -
Rapid Tumor Regression from PD-1 Inhibition After Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy in Refractory Diffuse Large B-Cell Lymphoma
Bone Marrow Transplantation (2020) 55:1184–1187 https://doi.org/10.1038/s41409-019-0657-3 CORRESPONDENCE Rapid tumor regression from PD-1 inhibition after anti-CD19 chimeric antigen receptor T-cell therapy in refractory diffuse large B-cell lymphoma 1 2 2 2 1,3 Brian T. Hill ● Zachary J. Roberts ● Allen Xue ● John M. Rossi ● Mitchell R. Smith Received: 24 January 2019 / Revised: 7 June 2019 / Accepted: 30 June 2019 / Published online: 30 August 2019 © Springer Nature Limited 2019. This article is published with open access To the Editor: large B-cell lymphoma (DLBCL), with strong PD-L1 expression, whose disease did not respond to axi-cel but Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 who experienced rapid tumor regression after receiving sub- chimeric antigen receptor (CAR) T-cell therapy approved by sequent anti-PD-1 therapy. the US Food and Drug Administration for adult patients with ZUMA-1 (NCT02348216) is a multicenter, phase 1/ relapsed/refractory large B-cell lymphoma after ≥2 lines of 2 study of axi‑cel in patients with refractory large B-cell 1234567890();,: 1234567890();,: systemic therapy [1, 2]. In ZUMA-1, the pivotal study of axi- lymphoma [3, 8, 9]. After leukapheresis and manufacturing, cel in refractory large B-cell lymphoma, with a median of patients received low-dose conditioning chemotherapy 27.1 months follow-up, the objective response rate was 83%, (cyclophosphamide 500 mg/m2 and fludarabine 30 mg/m2 including 58% complete responses [3]. Grade ≥3 cytokine intravenously, days −5to−3) and a single intravenous axi- release syndrome (CRS) and neurologic events occurred in cel infusion (target dose, 2 × 106 CAR T cells/kg, day 0). -
Kite Pharma Initiates Phase 1B/2 Combination Study for KTE-C19 and Atezolizumab in Patients with Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Kite Pharma Initiates Phase 1b/2 Combination Study for KTE-C19 and Atezolizumab in Patients with Refractory Diffuse Large B-cell Lymphoma (DLBCL) October 6, 2016 10:15 AM ET First patient enrolled in ZUMA-6 study evaluating safety and efficacy of anti-CD19 CAR (KTE-C19) therapy in combination with anti-PD-L1 monoclonal antibody atezolizumab SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite Pharma, Inc. (Nasdaq:KITE) today announced the first patient was enrolled in ZUMA-6, a Phase 1b/2 clinical study of KTE-C19 in combination with atezolizumab, Genentech's anti-PD-L1 cancer immunotherapy. The trial is designed to evaluate the safety and efficacy of the combination in patients with refractory diffuse large B-cell lymphoma (DLBCL). PD-L1 expression in DLBCL is associated with high-risk disease and poor outcomes. The interaction of PD-L1 and PD-1, which is expressed on KTE-C19, may dampen T-cell activity in some patients. As a result, use of the two compounds in combination could provide a synergistic effect since inhibiting PD-L1 with atezolizumab may enhance and prolong the activity and proliferation of KTE-C19. "The ZUMA-6 combination study is a core element of our broad strategy to optimize KTE-C19 treatment outcomes and to significantly extend the important potential benefits of KTE-C19 monotherapy," said David Chang, M.D., Ph.D., Kite's Executive Vice President, Research and Development, and Chief Medical Officer. "We view the scientific rationale for this combination study as compelling and look forward to advancing the study based on our extensive clinical experience." Kite entered a clinical collaboration in March 2016 with Genentech, a member of the Roche Group, to evaluate the safety and efficacy of KTE-C19 in combination with atezolizumab. -
The Cancer Immunotherapy Pilot Program and Chimeric Antigen Receptor-T Cell Treatments
Boston College Intellectual Property and Technology Forum http://bciptf.org THE CANCER IMMUNOTHERAPY PILOT PROGRAM AND CHIMERIC ANTIGEN RECEPTOR-T CELL TREATMENTS ELLEN SHAMANSKY Abstract: The Cancer Immunotherapy Pilot Program (also known as Patents 4 Patients) provides fast-track review to patent applications describing methods of treating cancer with immunotherapy, such as chimeric antigen receptor (“CAR”)- T cell treatments. This article explores considerations for claiming CAR-T cell treatments, including court rulings and examiner guidelines on patentable subject matter in the life sciences, the Federal Circuit’s decision in NantKwest, Inc. v. Lee in 2017, and pending applications and current litigation over CAR-T cell treatments. I. INTRODUCTION Cancer immunotherapy refers to biological treatments that use the immune system to combat cancer.1 These treatments, including monoclonal antibodies, antibody drug conjugates, cancer treatment vaccines, bacillus Calmette-Guérin therapy, gene therapy, and adoptive T-cell transfer therapy, take many approaches and have a variety of mechanisms of action.2 A point of commonality, however, is that all require more complicated production schemes than those used to manufacture small molecule drugs.3 Also, because biological treatments are living organisms, such as bacteria and viruses, or substances derived from living organisms, such as antibodies of the immune system, they 1 Biological Therapies for Cancer, NAT’L CANCER INST., https://www.cancer.gov/about- cancer/treatment/types/immunotherapy/bio-therapies-fact-sheet (last visited Apr. 26, 2018). 2 Id.; Game Changers: How CAR-T and Cell Therapy Are Revolutionizing Cancer Immunotherapy, FOLEY & LARDNER LLP (Dec. 7, 2017), https://www.foley.com/game- changers-how-car-t-and-cell-therapy-are-revolutionizing-cancer-immunotherapy-12-07- 2017/ [hereinafter Game Changers]. -
Kite Pharma and the Leukemia & Lymphoma
Kite Pharma and The Leukemia & Lymphoma Society(R) Enter Into Collaboration to Enhance the Development of KTE-C19 in Refractory Aggressive Non-Hodgkin Lymphoma and Launch CAR T-Cell Therapy Educational Programs July 1, 2015 4:15 PM ET SANTA MONICA, Calif. and WHITE PLAINS, N.Y., July 1, 2015 (GLOBE NEWSWIRE) -- Kite Pharma, Inc., (Nasdaq:KITE) and The Leukemia & Lymphoma Society (LLS) announced today that they have entered into a partnership to enhance the development of Kite's lead product candidate, KTE-C19, for the treatment of patients with refractory aggressive non-Hodgkin lymphoma (NHL). KTE-C19 is an investigational therapy in which a patient's T cells are genetically modified to express a Chimeric Antigen Receptor (CAR) designed to target CD19, a protein expressed on the cell surface of B cell lymphomas and leukemias. Under the collaboration, LLS will launch a broad scope educational program focusing on CAR T-cell therapy for the treatment of blood cancers, as well as support outreach for clinical trial enrollment. LLS also will contribute up to $2.5 million, through the Therapy Acceleration Program (TAP), to help fund Kite's ongoing Phase 1/2 clinical study of KTE-C19 (see ClinicalTrials.gov, using Identifier NCT: 02348216), which is designed to evaluate safety and efficacy in the treatment of patients with refractory diffuse large B cell lymphoma (DLBCL), as well as two rare lymphomas - primary mediastinal B cell lymphoma (PMBCL) and transformed follicular lymphoma (TFL). Based on the progress of the program, Kite will make certain milestone payments to LLS and provide financial support to LLS for its rollout of the education program. -
Kite Pharma Announces Patients with Aggressive Non-Hodgkin's
Kite Pharma Announces Patients With Aggressive Non-Hodgkin's Lymphoma Experience Positive Results After Receiving Anti-CD19 Chimeric Antigen Receptor (CAR) T Cells at the National Cancer Institute (NCI) August 25, 2014 11:23 AM ET Kite Pharma Announces Patients With Aggressive Non-Hodgkin's Lymphoma Experience Positive Results After Receiving Anti-CD19 Chimeric Antigen Receptor (CAR) T Cells at the National Cancer Institute (NCI) Phase 1-2a Clinical Trial Highlights: 12 of 13 Total Evaluable Patients with Advanced B Cell Malignancies Had Complete Remissions (8 Patients) or Partial Remissions (4 Patients) Resulting in a 92% Objective Response Rate 4 of 7 Evaluable Patients with Chemotherapy-Refractory Diffuse Large B-cell Lymphoma (DLBCL) Achieved Complete Remissions, 3 of Which Are Ongoing and 1 of Which Is Ongoing after 22 Months The Results Have Been Published in the August 25, 2014 Issue of the American Society of Clinical Oncology's (ASCO) Journal of Clinical Oncology The Results Support Kite's Plan to File an Investigational New Drug Application (IND) in the Fourth Quarter of 2014 to Initiate a Clinical Trial of Kite's Lead CAR-Based Product Candidate, KTE-C19, in Patients with DLBCL SANTA MONICA, Calif., Aug. 25, 2014 (GLOBE NEWSWIRE) -- Kite Pharma, Inc., (Nasdaq:KITE), a clinical-stage biopharmaceutical company focused on developing engineered autologous T cell therapy (eACT™) products for the treatment of cancer, today announced the publication of clinical results in a cohort of patients demonstrating the potential to treat aggressive non-Hodgkin's lymphoma with an anti-CD19 chimeric antigen receptor (CAR) T cell therapy. Kite's most advanced product candidate, KTE-C19, is an anti-CD19 CAR T cell therapy that involves genetically modifying a patient's T cells to express a CAR that is designed to target CD19, a protein expressed on the cell surface of B cell lymphomas and leukemias. -
Kite a Gileau Company
Protocol KTE-C19-106 Amendment #1 21 Sep 2017 Kite Phanna Inc. Kite A GILEAu Company PROTOCOL TITLE: A PHASE 1-2 MULTI-CENTER STUDY EVALUATING 1HE SAFETY AND EFFICACY OF KTE-C19 IN COMBINATION WITH ATEZOLIZUMAB IN SUBJECTS WITH REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) Protocol Number: KTE-C19-106 (ZUMA-6) Clinical Study Sponsor: Kite Pharma, Inc. 2225 Colorado Avenue Santa Monica, CA 90404 United States of America Key Sponsor Contacts: [PPD Sr. D... i. -r-e-ct,_o-r,--c finicafDeve opment Kite Pharma, Inc. [PPD Plione: PPD Email:[PPD PPD lVlanager, Cd~ ical Operations Kite Pharma, Inc. PPD Phone: i.P.P lJ Email: lP.PlJ Date: 21 Sep 2017 Confidentiality Notice This document contains confidential information of Kite Phanna Inc. This document must not be disclosed to anyone other than the site research staff and members of the institutional review board/independent ethics committee, a scientific review board or an equivalent. The information in this document cannot be used for any purpose other than the conduct of the clinical investigation without the prior written consent ofKite Pharma Inc. Questions regarding how this document should be used or the conduct of the clinical trial should be directed to the key sponsor contacts. Confidential Page 1 of93 Protocol KTE-C19-106 Amendment #1 21 Sep 2017 Kite Phanna Inc. INVESTIGATORS AGREEMENT A Phase 1-2 Multi-Center Study Evaluating the Safety and Efficacy of KTE-C 19 in Combination with Atezolizumab in Subjects with Refracto1y Diffose Large B-Cell Lymphoma (DLBCL) (ZUMA-6) dated 21 Sep 2017 and agree to abide by all provisions set f01th therein.