Neurotrophin & synaptogenesis Freddy Jeanneteau, Margarita Arango-Lievano, Moses Chao To cite this version: Freddy Jeanneteau, Margarita Arango-Lievano, Moses Chao. Neurotrophin & synaptogenesis. John Rubenstein; Pasko Rakic; Bin Chen; Kenneth Y. Kwan; Hollis T. Cline; Jessica Cardin. Synapse Development and Maturation (2nd edition), Elsevier, pp.167-192, 2020, 978-0-12-823672-7. 10.1016/B978-0-12-823672-7.00007-7. hal-02922106 HAL Id: hal-02922106 https://hal.archives-ouvertes.fr/hal-02922106 Submitted on 25 Aug 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Chapter Neurotrophin & synaptogenesis Freddy Jeanneteau1, Margarita Arango-Lievano1 & Moses V. Chao 2 1. Institut de genomique fonctionelle, departments of Physiology, Neuroscience, Inserm, CNRS, University of Montpellier, Monpellier, France 2. Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology & Neuroscience and Psychiatry, New York University Langone Medical Center, 540 First Avenue, New York, NY 10016, USA Correspondence: Email:
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[email protected] 1 Outline. Summary I. Introduction II. One neurotrophin, three ligands at the synapse II.1. Pro-BDNF II.2. Cleavage of Pro-BDNF II.3. The prodomain III. Which side of the synapse produce neurotrophins? III.1.