Table S1. Altered expression of IFN-β-related and apoptosis-related

induced by IFN-β (absolute fold-change; cut-off: 2.0, cell line specific analyses).

LNT-229 GS-2 GS-9 6 h (FC) 24 (FC) 6 h (FC) 24 h (FC) 6 h (FC) 24 h (FC)

IFIT1 308.3 IFI44L MX1 77.9 MX1 56.7 IFI44 150.3 IFI44L 293.0 IFN-β 246.8 IFI44L 213.0 IFITM1 155.6 IFIT1 60.7 IFIT1 49.9 IFIT1 134.7 IFI27 181.2 response IFIH1 74.6 IFI27 146.2 DDX58 53.9 DDX58 43.1 IFI44L 120.4 IFITM1 172.9 DDX58 67.5 IFIT1 IFIH1 31.1 ISG20 41.8 IFI44 116.4 IFI44 163.8 genes 80.5 IFIT3 67.1 IFI6 46.0 IFIT2 26.7 IFIH1 35.0 IFIH1 110.6 IFIH1 102.6 IFITM1 61.7 IFI44 24.8 IFIT3 23.0 IFIT2 30.8 DDX58 90.8 IFIT1 82.4 IFIT2 46.3 DDX58 18.2 ISG20 18.1 ISG20 27.3 IFIT3 71.7 IFI6 77.0 GBP1 38.7 IFIT3 18.0 IFI44L 17.8 IFIT3 23.1 IFITM1 69.0 IFI44 76.2 IFI44 38.0 IFIH1 15.0 GBP1 17.3 IFI6 16.8 IFIT2 53.8 IFITM3 57.4 IFI6 28.4 IRF7 14.9 IFI44 13.0 IFI27 16.7 IFITM1 48.6 DDX58 51.4 IFI27 24.4 IFITM2 7.7 IRF7 12.2 IFI44L 15.2 GBP1 39.4 IFIT3 48.1 IRF7 17.7 IFITM3 7.0 IFI6 11.8 IFITM1 14.5 IFI6 32.1 IFI35 27.7 ISG20 14.1 IFI35 6.9 ISG20 10.3 IFI35 12.3 IFI27 27.9 IFITM2 18.3 IFI35 11.6 IRF9 5.3 IFITM1 10.2 GBP1 11.7 IFI35 25.7 IRF9 18.2 IFIT5 11.2 ISG20 4.7 IFI27 8.0 IFI44 11.0 IRF9 19.9 ISG20 17.9 GBP2 9.3 GBP1 4.6 IFIT5 7.6 IRF7 8.6 IFITM3 16.9 IRF7 16.9 IRF1 6.3 IFIT5 4.5 IFI35 6.7 IFIT5 5.6 IRF7 16.9 GBP1 14.5 IRF9 6.1 IFIT2 3.1 IFI16 5.6 IRF9 4.9 IFITM2 10.7 IFIT2 10.5 IFI16 5.7 IFI16 3.0 IRF9 5.1 IFI16 4.8 ISG20 10.1 IFIT5 7.1 IFITM2 3.7 MX1 3.0 IRF1 4.6 IFITM2 4.3 IFIT5 8.4 IFI16 4.4 IFITM3 3.3 IFI30 2.5 PML 2.9 IFI30 4.1 IRF1 5.2 IFI30 3.3 PML 3.3 PML 2.3 IFITM2 2.9 IRF1 3.8 IFI16 5.0 IRF1 2.5 IRF2 2.7 IFITM3 3.4 IRF2 3.6 PML 2.1 IFITM3 2.6 PML 3.2 PML 3.4 IRF2 2.4 IFI30 2.2

IFI1 74.6 IFI27 146.2 MX1 77.9 TRAIL 100 IFIH1 110.6 IFI27 181.2 Apoptosis- XAF1 65.7 XAF1 52 TRAIL 74.7 MX1 56.7 STAT1 36.4 IFIH1 102.6 related TRAIL 62.7 IFI6 46 IFIH1 31.1 IFIH1 35 IFI6 32.1 IFI6 77 IFI6 28.4 IFIH1 15 XAF1 24.5 XAF1 20.4 XAF1 28.5 XAF1 57.2 genes IFI27 24.4 STAT1 12.5 STAT1 10.3 IFI6 16.8 IFI27 27.9 STAT1 27.8 STAT1 14 EIF2AK 4.3 IFI27 8 IFI27 16.7 TRAIL 21.1 CASP1 10.9 CASP1 6.1 2 CASP1 5.9 STAT1 16 CASP1 5.9 IER3 6.4 EIF2AK 4.6 TRAIL 3.5 EIF2AK 4.3 CASP1 6.8 EIF2AK 4.9 EIF2AK 4.3 2 MX1 3 2 3.7 TNFAIP 5.2 2 2 CASP7 3.3 CASP1 2.4 JAK2 3 PML 3.4 TNFAIP 4.3 PML 3.3 PML 2.3 PML 3.2 SRGN 3.5 ADAR 3.2 3 BCL2L 3.2 ADAR 2.2 BTC 3.0 PML 3.2 CASP7 3.1 TRAIL 4 13 BIRC3 2.1 CASP4 2.8 JAK2 3.2 ADAMT 2.6 ADAR 2.6 JAK2 2.9 ADAR 2.3 EIF2AK 3.1 S20 BTC 2.4 FAS 2.6 CASP7 2 2 BCT 2.6 CASP7 2.4 MX1 2.5 MCL1 2 NFKBIA 3 FAS 2.4 PML 2.1 PMAIP 2.4 FAS CASP4 2.8 BCL2L1 2.4 AHR 2.1 1 ADAR 2.7 3 GADD 2 CASP4 2.3 BTC 2.6 PMAIP1 2.3 45B ADAR 2.3 BCL2L 2.4 TNFRSF 2.2 BTC 2.2 13 21 RIPK1 2.1 BIRC3 2.3 GADD 2.2 45B MCL1 2.2 CASP7 2

Table S2. Altered of growth-related genes in LTL and GIC induced by

IFN-β (absolute fold-change; cut-off: 2.0, exclusive analyses).

6 h

gene FC GO

LNT-229 2.18 Negative regulation of proliferation TLK2 2.12 Cell cycle IL8 2.09 Cell cycle arrest, negative regulation of proliferation GS-2 IDO1 5.37 Negative regulation of proliferation SSTR2 3.70 Negative regulation of proliferation PTGS2 2.71 Negative regulation of proliferation GS-9 NKX3-1 2.56 Negative regulation of proliferation PML 2.40 Cell cycle arrest, negative regulation of proliferation, negative regulation of FOXN3 -2.31 Cell cycle NRSA2 -2.13 Cell cycle

24 h

gene FC GO

LNT-229 DHRS2 2.78 Negative regulation of proliferation RARRES1 2.01 Negative regulation of proliferation NF1 2.01 Negative regulation of proliferation HDGFRP3 -2.19 Cell proliferation EGR1 -2.17 Cell proliferation GS-2 IL8 11.51 Negative regulation of proliferation, cell cycle arrest EREG 11.12 Negative regulation of proliferation SOD2 10.46 Negative regulation of proliferation PTGS2 10.24 Negative regulation of proliferation IL6 6.92 Negative regulation of proliferation BDKRB2 3.79 Negative regulation of proliferation IGFBP3 3.74 Negative regulation of proliferation PML 3.19 Negative regulation of proliferation, negative regulation of cell growth, cell cycle arrest JAK2 3.16 Negative regulation of proliferation ADM 2.99 Negative regulation of proliferation CXCL1 2.56 Negative regulation of proliferation RARRES1 2.01 Negative regulation of proliferation EVIS -3.29 Cell cycle, cell proliferation, cell division SEPT11 -2.24 Cell cycle, cell division RASSF2 -2.24 Cell cycle NDP -2.18 Cell proliferation APPL2 -2.17 Cell cycle, cell proliferation GAS1 -2.06 Cell cycle, cell proliferation CENPE -2.03 Cell cycle, mitosis, cell division GS-9 GABBR1 23.70 Negative regulation of proliferation ADAMTS1 3.68 Negative regulation of proliferation AGT 3.17 Negative regulation of proliferation SIK1 2.19 Negative regulation of proliferation, cell cycle regulation KLF10 2.19 Negative regulation of proliferation JUN 2.14 Negative regulation of proliferation, cell cycle regulation CDCA3 -2.10 Cell division, cell cycle