RE_VIRAL DSRNA:TLR3:TRIF RE_ACTIVATED BI_TOLL COMPLEX REFERENCE TLR4 ACTIVATES SIGNALLING PATHWAY NODE RE_TRAF6 RIP1 MEDIATED Tlr3 > Trif INDUCTION OF RE_P75NTR PROINFLAMMATORY SIGNALS Traf3 > Irf3 > Stat1 CYTOKINES VIA NF-KB } RE_MYD88 RE_RIG-I/MDA5 CASCADE MEDIATED BI_STRESS Mda5 > Mavs PATHWAY INITIATED ON RE_TOLL LIKE INDUCTION RECEPTOR 3 PLASMA OF MEMBRANE (TLR3) CASCADE IFN-ALPHA/BETA PATHWAYS Ngf > p75NTR NF-gB NC_TNF GO_0035631 RECEPTOR (CD40 SIGNALING Traf6 RE_MYD88 PATHWAY RECEPTOR DEPENDENT RE_TOLL LIKE COMPLEX) RE_TOLL LIKE }{ CASCADE RE_TOLL LIKE RECEPTOR 4 RECEPTOR 2 Tlr4/Ly96/Cd14 Mapk8 INITIATED ON RECEPTOR 7/8 (TLR4) CASCADE ENDOSOME (TLR7/8) CASCADE BI_CD40 CASCADE PATHWAY RE_TOLL LIKE RECEPTOR 1) Innate immunity TLR6:TLR2 CASCADE RE_TOLL LIKE RE_TOLL LIKE RECEPTOR RECEPTOR 9 TLR1:TLR2 (TLR9) RE_TRAF6 CASCADE NC_IL1-MEDIATED MEDIATED CASCADE SIGNALING RE_MYD88-INDEPENDENT INDUCTION OF EVENTS NFKB AND MAP GO_0001772 CASCADE INITIATED ON KINASES UPON GO_0031669 (IMMUNOLOGICAL TLR7/8 OR 9 PLASMA RE_NFKB AND (CELLULAR SYNAPSE) ACTIVATION RE_TOLL LIKE MEMBRANE RESPONSE TO MAP KINASES RE_MYD88:MAL RECEPTOR 5 GO_0002756 NUTRIENT ACTIVATION CASCADE (TLR5) (MYD88-INDEPENDENT LEVELS) MEDIATED BY INITIATED ON TOLL-LIKE CASCADE TLR4 PLASMA RECEPTOR SIGNALING MEMBRANE SIGNALING REPERTOIRE RE_TOLL PATHWAY) RECEPTOR CASCADES RE_TOLL LIKE RECEPTOR 10 (TLR10) GO_0050856 CASCADE (REGULATION OF T CELL RECEPTOR SIGNALING Aspects of autophagy PATHWAY) Dap3/Cflar

NC_TRAIL SIGNALING PATHWAY Bag4/Dusp3 } Cell fate Tradd/Rip > Mapk8

GO_0005901 (CAVEOLA)

BI_MET

GO_0046626 GO_0043560 PATHWAY (REGULATION (INSULIN OF INSULIN RECEPTOR mTorC1/2 RECEPTOR SIGNALING SUBSTRATE PATHWAY) Insr Pi3k > Akt FoxO3 BINDING) Regulation of epithelial cell Igfr1 }{ Ikk complex proliferation via Met > Jun/Fos and cell mobility via Met > Stat3 NC_INSULIN PATHWAY

GO_0008286 (INSULIN RECEPTOR SIGNALING 2) Insr / Igfr1 signaling PATHWAY)

NC_A6B1 AND NC_E- A6B4 SIGNALING INTEGRIN IN SIGNALING BI_PTEN KERATINOCYTES PATHWAY Integrin- and growth factor-

BI_ECM pathway cross-talk PATHWAY GO_0031581 ( NC_SIGNALING KE_05100 ASSEMBLY) (BACTERIAL EVENTS Laminin 5-mediated INVASION OF MEDIATED EPITHELIAL BY FOCAL CELLS) ADHESION epithelial cell-ECM anchorage KINASE NC_E-CADHERIN Dissassembly of focal SIGNALING IN THE NC_ALPHA4 NASCENT BETA1 ADHERENS BI_MCALPAIN INTEGRIN JUNCTION adhesions PATHWAY SIGNALING EVENTS BI_UCALPAIN Adherens PATHWAY junction-signaling Sensing and cell polarization (Ras1, Rac1, Cdc42) GO_0009925 3) & motility (BASAL PLASMA GO_0014704 BI_INTEGRIN MEMBRANE) GO_0044291 (INTERCALATED KE_04520 (CELL-CELL PATHWAY DISC) (ADHERENS CONTACT JUNCTION) ZONE) NC_INTEGRIN-LINKED KINASE SIGNALING

GO_0017166 Tgf`> Smad2/4 (VINCULIN Focal adhesion BINDING)

GO_0005924 GO_0005925(CELL-SUBSTRATE signaling (FOCAL ADHERENS ADHESION) JUNCTION) GO_0030055 GO_0045216 (CELL-SUBSTRATE (CELL-) JUNCTION GO_0030027 ORGANIZATION) (LAMELLIPODIUM) Cell-cell

GO_0005913 (CELL-CELL ADHERENS adherens junctions JUNCTION)

GO_0030865 (CORTICAL GO_0016323 ORGANIZATION) (BASOLATERAL GO_0043296 PLASMA (APICAL MEMBRANE) JUNCTION COMPLEX) GO_0016328 (LATERAL PLASMA MEMBRANE) GO_0005911 (CELL-CELL JUNCTION)

GO_0001725 (STRESS FIBER) GO_0030057 () GO_0032432 (ACTIN GO_0042641 FILAMENT (ACTOMYOSIN) Desmosome BUNDLE) Protrusion of the cell’s

GO_0030864 (CORTICAL ACTIN Cell body leading edge CYTOSKELETON) translocation GO_0016327 (APICOLATERAL PLASMA MEMBRANE) and retraction

Cytoskeleton organization Apicolateral plasma membrane

GO_0001726 & tight junctions (RUFFLE)

GO_0031941 GO_0005884 (FILAMENTOUS (ACTIN ACTIN) FILAMENT)

GO_0005923 Intracellular () vesicle motility

GO_0005938 (CELL CORTEX)

4) Cell-cell junctions & cytoskeleton GO_0032587 (RUFFLE organization MEMBRANE)

Figure 3 in the manuscript 1 Additional fi le 3 REFERENCE ikbke ikbkg madd NODE atf2 cd14 map2k3 1) Innate immunity map2k4 chuk arhgdia dusp3 map2k7 CLUSTER bcl10 fos gab1 pdpk1 pik3r2 pik3r3 01-01 adrb2 grb2 itgb1 abca1 cbl dlg1 map3k7 atg12 atg13 prkca exoc1 exoc3 exoc5 pik3ca atg16l1 atg3 ly96 atg4c atg5 exoc6 foxo3 cblb jun pik3cb atg9a becn1 prkcd dusp3 mapk14 chmp1a elf1 malt1 pawr cln3 grb14 CLUSTER dusp1 ikbkap pik3r1 ctsd eif2ak4 prkcz 01-02 mapk3 gas6 hdac6 ptpre grb2 ptprj pip5k1a plcg1 hras1 mapk8 ikbkb hspa5 jun src map1lc3a rela rnf31 traf3 vasp zyx mll5 mtor nbr1 npc1 mapkapk3 ogt pik3c3 psen1 rptor traf6 slc2a1 mef2a ube2n ube2v1 srebf1 mef2c tnrc6a vdr ptpn11 wrn nfkb2 pik3c3 rps6ka3 ptpra rapgef1 adipor1 rasa1 sgk1 shc1 pik3r4 rps6ka5 akt1 hk1 igf1r ppp2cb sik2 tab3 tbk1 CLUSTER tirap tlr3 akt2 tlr4 tollip sorbs1 insr irs1 02 rela ctnna1 ctnnd1 sos1 trip10 jup jak2 phip met pak1 bcar1 ctsb pik3ca eif4ebp2 dlc1 pik3cb tsc2 flot1 pik3r1 map4k2 rffl zfp106 enpp1 inppl1 flot2 pten map4k3 ptk2 nfkb1 ripk1 irak1 ptk2b map2k1 nfkbia tank ptpn11 ngf mavs pxn tradd irf3 prkci raf1 rasa1 prkcz sos1 src 2) Insr / Igfr1 signaling stat3 smpd2 bag4 acta1 sqstm1 birc2 crk pik3r2 nfkbib cyld casp2 casp1 stat1 birc3 dock1 pik3r3 cflar dap3 ifih1 ubc

cldn4 itgb4 krt14 krt5 met pik3ca pik3r1 col17a1 prkca sfn lama3 CLUSTER shc1 ywhab 03-01 egf erbb3 grb2 erbb2 ywhag lamb2 ywhah lamb3 ywhaz hras1 itgb1 lamc2 capzb cdk5 bsnd pip5k1c tesc myo1c akt1 dlg1 cadm1 tmod3 erbb2ip ctnna1 cd9 dst cftr rac1 tsc1 plec ctnnd1 cttn col17a1 dnm1l dnm2 ddr1 spp1 vasp slco2b1 gab1 src slco3a1 dock1 CLUSTER dlc1 thbs1 trf vcl ilk ilkap 03-02 dlg1 dsp iqgap1 jup dst zfp384 kcnq1 tln1 ebag9 zyx keap1 adam9 afap1 ywhaz lama3 ank3 ap2a1 arrb1 enah 3) Focal adhesion & motility arrb2 atp7a epb4.1l5 abcc1 abi1 lims2 abi2 epcam lpp actr3 bcar1 ephx2 actn1 akt1 luc7l3 erbb2 arhgap26 cdkn1b grb2 grb7 arhgef6 erbb2ip arhgef11 nexn numb grlf1 itgav arhgef7 add3 ahnak erbb3 amotl2 keap1 krit1 apc strn sympk ldb1 pak1 flnb rictor lama3 pdk2 pdpk1 pdlim7 itgb1 amot arhgap17 magi1 git1 tns1 arhgef2 lin7c pik3ca anxa2 synpo pkd1 plec jam2 prkar1a igsf8 tns4 prkar1b ptk2b pip5k1a pld1 ash1l cadm1 marveld2 trf dlc1 enah tjap1 ptpra fermt2 cgn cldn23 micall2 ptk2 cbl cldn3 cldn4 ap1m1 itgb5 fat1 tjp1 ptprm cblb flnb hdac4 mpdz ccnd1 jun fgd4 cldn7 crb3 cblc gsn raf1 ilk kat2b tjp2 tjp3 cd2ap cdc37 map2k1 rock1 mpp5 cdc42 diap1 inppl1 map2k4 myh11 pxn cltb git2 myo10 shc1 ctnna1 mapk8 myo9b mpp7 CLUSTER cltc hsp90aa1 mapk8ip3 nckap1 myh14 rfwd2 scrib hsp90ab1 ctnnd1 mtdh 04 crk nme1 palld slc22a5 slc2a1 erbb2 farp2 fgfr1 slc9a1 slco2b1 arpc1a igf1r insr iqgap1 ocln pak1 slco3a1 bcr rapgef1 pdlim7 sept7 acta1 pik3cb arpc1b lmo7 map3k7 capn1 rasa1 mapk3 ptk2 sorbs1 rock2 arpc3 ptpn11 mapk3 met pik3r1 st14 stx4a capns1 rras mylk arpc4 pten mllt4 nlk stxbp3a egf sos1 arpc5l sorbs1 actn1 syne2 src ssx2ip tcf7l1 rdx tcf7l2 tgfbr1 baiap2 akt2 parp1 actn4 tenc1 scyl3 wasl cd14 acta1 als2 ppp1r12a tgfbr1 tjp1 slc39a6 yes1 cd81 coro1c amot ppp1r14a erbb3 vav2 stxbp2 tmsb15l dlg1 cyfip1 pik3r2 tpm1 dlg5 ptpn6 ptprj ptprk epcam dbnl pik3r3 met capn2 2900073g15rik arhgap5 prkar2a xpo1 jup scrib tpm3 dsc2 ptprm fzd6 kifc3 mpz f11r nf2 ppp1r12b synm plcg1 nf2 numb dsg2 igsf5 vcl pard3 shroom2 inadl dsp slc2a1 plekha7 shroom3 jam2 zyx pmp22 gnpat prkci itgb1 gipc1 gm2a itch itgb4 itpr2 ndfip1 nedd4 ppp1r9a clasp1 clasp2 lamc2 lancl2 lasp1 llgl1 macf1 cnksr1 ctgf ccm2 dstn pkp1 pkd1 map2k1 mapre1 mark2 pnn cd9 lancl2 prkcz cttn cytip lasp1 prkcd spna2 cdc42 9030425e11rik abi2 llgl1 daxx dbnl spnb2 spnb3 cdh1 ppp1r9a rac3 prkcz myo9b dstn utrn crebbp scnn1a pvrl2 pvrl4 nf2 palld pdlim7 shroom2 epb4.1l5 rac1 spna2 spnb2 spnb3 tchp eps8l2 rac3 ehd2 smad7 pip5k1a smad2 epb4.1 tgfb1 ezr frmd4b smad4 epb4.1l1 tgfb2 wasl plekha1 rab34 rab5a vcl vps11 tpm3 inpp5j snai2 epb4.1l2 tgfb3 yes1 akap7 tln1 stx3 gja1 anxa5 rasa1 rdx s100a6 sh2b1 vps16 synj2 tesc tln1 CLUSTER 03-03 tmod3 fermt2 fkbp15 gng12 tmsb15l flna sept2sept7 actn1 actn4 myo1c add3 capza1 capza2 tpm1 cd2ap trpm7 myo6 dlc1

acta1 afap1 amot arhgap1 psen1 4) Cell-cell junctions & cytoskeleton psen2 tsc1 epb4.1 arhgef2 ptk2b usp2 exoc6 organization bcar1 scnn1a utrn exoc8 acap2 tnfrsf12a

Figure 4 in the manuscript 2 Additional fi le 3 1) ECM turnover 3) Neurotransmission

GO_0051971 REFERENCE (POSITIVE REGULATION NODE OF TRANSMISSION OF NERVE IMPULSE)

GO_0030199 RE_NCAM1 (COLLAGEN INTERACTIONS Positive regulation FIBRIL ORGANIZATION) GO_0005234 (EXTRACELLULAR-GLUTAMATE-GATED of nerve impulses ION GO_0008066 CHANNEL PF_01410 ACTIVITY) (FIBRILLAR (GLUTAMATE COLLAGEN RECEPTOR GO_0022834 GO_0004970 C-TERMINAL ACTIVITY) DOMAIN) GO_0005583 PF_00093 (LIGAND-GATED (IONOTROPIC (FIBRILLAR (VON CHANNEL GLUTAMATE COLLAGEN) WILLEBRAND ACTIVITY) GO_0008328 FACTOR RECEPTOR Collagens TYPE C (IONOTROPIC ACTIVITY) DOMAIN) PF_00060 GLUTAMATE (LIGAND-GATED RECEPTOR (all structural classes) ION COMPLEX) CHANNEL)

GO_0005581 GO_0015276 GO_0005230 (COLLAGEN) Cys-loop receptors (LIGAND-GATED (EXTRACELLULAR ION LIGAND-GATED PF_01391 CHANNEL (COLLAGEN ION (all categories) ACTIVITY) TRIPLE CHANNEL HELIX GO_0005231 REPEAT (20 (EXCITATORY ACTIVITY) COPIES)) Contact activation PF_00090 EXTRACELLULAR PF_01094 (THROMBOSPONDIN LIGAND-GATED (RECEPTOR TYPE 1 DOMAIN) ION FAMILY pathway (coagulation) CHANNEL LIGAND ACTIVITY) BINDING Angioinhibitory REGION) BI_INTRINSIC PATHWAY signals

GO_0005578 (PROTEINACEOUS EXTRACELLULAR MATRIX) GO_0031012 2) Gap junctions (EXTRACELLULAR MATRIX)

GO_0005921 PF_10582 (GAP () PF_00045 JUNCTION CHANNEL (HEMOPEXIN) CYSTEINE-RICH DOMAIN) Formation and structural

Core components PF_00029 Mmp-mediated () organization of the ECM of gap junctions collagenolysis

GO_0005922 ( GO_0043205 PF_00413 A COMPLEX) (FIBRIL) (MATRIXIN) 1) ECM turnover 3) Neurotransmission

accn1 accn2 accn3 gabrr1 gabrr2 REFERENCE accn5 chrna1 glra1 glra2 grik4 grin2d NODE chrna2 glra3 glra4 glrb htr3a htr3b chrna3 grik5 kcnh2 kcnh7 kcnj1 kcnj10 kcnj12 kcnj14 chrna5 gria1 kcnj2 kcnj3 kcnj4 kcnj5 chrna6 kcnj6 kcnj8 kcnj9 grin1 p2rx1 p2rx3 chrna7 gria2 p2rx5 p2rx6 c1ql2 c1ql3 c1qtnf1 c1qtnf2 chrna9 c1qtnf3 c1qtnf6 c1qtnf7 col4a1 grin2a pex5l ryr2 trpc1 trpc2 col10a1 col11a1 col5a1 chrnb1 trpc6 col4a2 gria3 col11a2 col12a1 col13a1 col4a3 col14a1 col15a1 col19a1 chrnb2 grin2b grin3a col5a2 col4a5 chrnb3 gria4 shisa9 col4a6 f10 grm1 casr col1a1 col6a1 f12 f2 f8 f9 fga chrnb4 chrnd col5a3 grin2c grm2 htr6 gabbr1 fgb fgg klkb1 ifng gprc2a-rs5 col6a2 gdnf proc serpinc1 chrne chrng grm3 il6 clca5 cnga4 cngb3 grid2 grm5 itga2 lama2 camk2b col1a2 grm7 col6a3 gabra1 gabra2 lgi1 cartpt col23a1 col24a1 col25a1 col6a4 grm8 ncs1 cckbr col8a2 gabra3 gabra4 gucy2c nmu ccl2 CLUSTER grik1 nr2e1 gucy2e oxt col9a1 gabra5 gabra6 CLUSTER gucy2g drd1a oxtr col2a1 col9a2 ecm2 npr1 egfr ptgs2 01-01 colec10 fras1 gabrb1 gabrb2 gfap npr3 slc1a3 colec11 nell1 03 gip gabrb3 gabrd grik2 tas1r1 snca colq eda nell2 tas1r2 tacr1 emid2 nov gabrg1 gabrg2 vmn2r10 tnf cnih2 emilin1 pxdn col3a1 grik3 vmn2r84 tnr cnih3 fcna sspo gabrg3 gabrq vmn2r88 uts2 dlg4 gm7455 thbs2 foxc2 mbl2 vwc2l lmx1b bmper scara3 vwce plod3 chrdl1 sftpa1 wisp1 serpinh1 chrdl2 acan cntn2 sftpd wisp2

a930038c07rik acan ahsg alb ambn hmcn1 igf1 amelx angptl4 mmp9 ache ihh kera lama1 aspn bmp7 clec3b lama2 lama4 muc2 ndp nepn adamts12 col10a1 nid1 nid2 nov lamb1 loxl1 lpl adamts16 2) Gap junctions col11a1 lum mamdc2 npnt ntn3 oc90 col11a2 matn3 mepe olfml2a olfml2b optc adamts19 col12a1 mfap2 mfap4 otoa papln calb2 col14a1 adamts20 prss36 ptn col15a1 col1a1 adamts3 gjb6 mmp10 pxdn rbp3 rptn gja10 col1a2 col24a1 adamts5 serac1 serpine1 sftpa1 col2a1 col3a1 adamts6 mmp11 sftpd shh slc1a3 gja5 gjc3 col4a1 col4a2 adamts7 col4a5 col4a6 smoc2 snca sod3 gjd2 mmp13 sparc sparcl1 adamts8 gja8 CLUSTER spock1 mmp14 adamts9 gjb2 gjd4 01-02 spon2 tecta col5a1 col5a2 mmp16 tectb tff3 tgfbi adamtsl1 gjb3 gje1 col5a3 col6a1 thbs2 thbs4 adamtsl2 mip panx3 col6a2 col6a3 mmp19 bai2 bai3 c6 c8b col8a2 col9a1 thsd4 timp1 gjb4 thsd7a CLUSTER unc5c col9a2 cpa6 cpz thsd1 rspo1 sspo mmp1a tnr ush2a vcan unc5d 02 crtap dmbt1 wisp1 fbn1 wisp2 hpx gjb5 dspp ecm2 vit vtn wnt1 wisp3 fbn2 efemp2 eln mmp1b wnt10a wnt10b mfap2 emid2 emilin1 wnt2 wnt2b slc1a3 emilin3 enam mmp2 wnt3a wnt8a epyc fbln5 fbn1 wnt9a wnt9b zg16 snca GO_0043205 (FIBRIL) fbn2 fras1 mmp20 zp1 zp3 frem1 frem2 thsd4 mmp23 mmp7 gabra6 gpc2 gpc3 gpc5 gria3 grin1 grin2b mmp8 B hapln1 hapln3

Figure 5 in the manuscript 3 Additional fi le 3 1) Adaptive immunity 2) Neurotransmission

KE_04672 (partial reversal) (INTESTINAL GO_0030594 REFERENCE IMMUNE (NEUROTRANSMITTER NODE NETWORK RECEPTOR FOR IGA Interferons (Inf_-1, PRODUCTION) ACTIVITY) KE_05320 -5,-9, Ifitm1) (AUTOIMMUNE THYROID DISEASE) B-cell activation and differentiation Neurotransmitter (BAFF-system/Cd40(l)/Icos(l)/Il4/Aicda) receptor expression (specific for several NK-cell-mediated pos. & neg. regulation classes of ligands) of cytotoxic activity GO_0005892 KE_05340 GO_0009897 (NICOTINIC (PRIMARY (EXTERNAL ACETYLCHOLINE-GATED IMMUNODEFICIENCY) SIDE OF PLASMA RECEPTOR-CHANNEL MEMBRANE) COMPLEX) Ag-presentation via MHCII BI_THELPER Immunological synapse Nicotinic acetylcholine receptors PATHWAY & tertiary signals (neuronal & muscle type)

RE_IMMUNOREGULATORY INTERACTIONS BETWEEN A GO_0042165 LYMPHOID (NEUROTRANSMITTER AND A BINDING) T-cell activation NON-LYMPHOID CELL PF_02931 PF_02932 (NEUROTRANSMITTER-GATED (NEUROTRANSMITTER-GATED ION-CHANNEL BI_TCYTOTOXIC ION-CHANNEL PATHWAY LIGAND TRANSMEMBRANE ACh-, GABA- & Gly- BINDING REGION) A gated ionotropic receptors DOMAIN) 1) Adaptive immunity 2) Neurotransmission (partial reversal) REFERENCE NODE

5830411n06rik itgae ache anxa9 brs3 cckbr drd1a drd2 gabra3 ace aqp4 btla h2-ab1 cd8a ccl19 ccr4 ccr7 drd3 h2-dma itgal gabra4 cd19 chrm4 cd8b1 h2-dmb2 itgb2 chrna1 gabra6 cd2 gabra2 gabrb1 cr2 ctla4 cxcl10 h2-eb1 ptprc chrna3 galr2 galr3 gabrb2 cxcl12 cxcl9 cd200r4 h2-m3 cd247 s1pr1 gpr143 gpr83 gabrb3 cxcr3 cxcr4 h2-oa sell sema7a spn stab2 grin1 grin2a grin2b fcer2a chrna4 grin2d grin3a gabrd fas cd3d h2-ob h2-q7 h2-q8 ifna1 ifna5 grin3b htr7 gabre fcgr2b hcst thy1 cd3e ifna9 il2 il4 chrna5 chrna6 kiss1r mc2r gabrg1 tg tpo tshb icam1 cd3g mrgpra1 gabrg2 icam2 ifitm1 CLUSTER chrna7 mrgpra4 gabrg3 01 nmbr nmur1 gabrp chrna9 nmur2 npffr2 gabrq ciita npy1r ntsr1 gabrr1 icos chrnb1 ntsr2 ppyr1 gabrr2 rag2 CLUSTER cd209b cd22 cd244 slc18a3 cd274 icosl prokr2 glra1 cd40 chrnb2 02 slc6a11 slc6a13 igh-6 tnfrsf13b glra2 il2rb sstr1 sstr2 cd40lg glra3 cd28 il2rg tnfrsf13c chrnb3 sstr4 sstr5 cga zap70 glra4 cd86 il7r tacr1 tacr2 lck htr3b chrnb4 tacr3 tspo itga4 itgb7 cd48 cd5 tnfrsf18 itgax cd69 cd74 tnfrsf4 aicda kcnj3 klrg1 chrnd tnfrsf9 btk klrd1 cd79a ulbp1 klrk1 cd79b tnfrsf17 B ms4a1 cd83 cd4 vcam1 madcam1 tnfsf13b chrne chrng

Figure 6 in the manuscript 4 Additional fi le 3 1) Focal adhesion & cell-cell junctions (partial reversal)

REFERENCE GO_0016327 NODE (APICOLATERAL PLASMA MEMBRANE) GO_0016328 (LATERAL PLASMA MEMBRANE)

KE_04530 (TIGHT Cell-cell JUNCTION)

GO_0043296 adherens junctions (APICAL JUNCTION COMPLEX)

GO_0005913 Apicolateral plasma (CELL-CELL ) membrane & tight junctions

GO_0005923 GO_0005911 (TIGHT (CELL-CELL JUNCTION) JUNCTION)

GO_0030055 (CELL-SUBSTRATE GO_0007044 JUNCTION) (CELL-SUBSTRATE JUNCTION ASSEMBLY) GO_0034329 (CELL GO_0005925 JUNCTION (FOCAL ASSEMBLY) ADHESION)

GO_0005924 (CELL-SUBSTRATE Focal adhesion ADHERENS JUNCTION) NC_SIGNALING EVENTS MEDIATED BY maturation FOCAL ADHESION KINASE

GO_0005901 BI_INTEGRIN (CAVEOLA) A PATHWAY

1) Focal adhesion & cell-cell junctions (partial reversal)

REFERENCE pik3ca ankrd23 anxa5 slc5a1 epb4.1 epb4.1l1 ptpn21 ldb1 itga6 itgb3 erbb2ip lin7c fhl2 epb4.1l2 arhgef2 itgb4 spna2 NODE pard3 flnb git1 exoc3 exoc4 b4galt1 cdc42bpa magi1 ssx2ip stx3 pxn pard6a jub hic2 ilk f11r rfwd2 magi3 sympk gnai1 gnai3 lims1 irf2 hras1 sdc1 cdh1 pard6g synpo ppp2ca ppp2cb marveld2 lpp 2900073g15rik actg1 col17a1 tiam1 igsf5 actn4 akt1 akt2 ppp2r1a ppp2r1b itgb1 sdc4 ppp2r2c ppp2r2d mdc1 dpp4 micall2 amotl1 dag1 prkcd prkce nexn jun tjp1 inadl syne2 prkch itgb5 b230120h23rik cask dsc2 gja1 gjb1 mpp5 tenc1 pak1 map2k1 tjp2 jam2 cdk4 prkcz map2k4 mapk1 cgn tgfb1i1 gjb2 mpp7 kras llgl2 jup parva mapk3 mapk8 prkd1 myo1c tjp3 cgnl1 tln2 ptk2 ocln p2rx7 pgm5 ppp1r12b ptprj ptprk cldn1 tns4 pkp3 plekha7 trip6 pvrl2 cldn10 shroom2 cldn23 vcl zfp384 CLUSTER cldn3 01 cldn4 atp1b3 ldlr cdh13 cln3 cldn7 dlc1 cav1 lipe arhgap26 ctnnb1 krt14 krt5 gnaq hdac6 dst arhgef11 cdh13 myof clic4 cldn8 hk1 igf1r insr ldlr ebag9 ctnnd1 lama3 arhgef7 lipe myof cln3 ptrf csnk2a1 crb3 ptrf slc27a1 enah cxadr lamb3 cald1 csnk2a2 csnk2b slc2a1 lamc1 dlc1 slc27a1 smpd2 epb4.1l5 epcam lamc2 cav1 rab13 tsc2 ctnna1 src fn1 gnpat erbb3 pdpk1 plec crkl itga1 sgsm3 gnaq slc2a1 cttn braf hdac6 smpd2 smad3 capn2 myh10 taok2 ccnd1 myh11 keap1 rac1 crk myh14 tesk2 arhgap6 hk1 src pkp1 dock1 myl12b raf1 tns1 kifc3 2310057j16rik grb7 myl9 rgnef cd151 tsc1 kirrel add3 pmp22 grlf1 nras rock2 cd9 mllt4 igf1r tsc2 bcr GO_0005901 capn1 mapk9 insr B capns1 nck2 pcdh1 tmem47 akap7 dlg5 rras2 map2k2 fzd6 atp1b3 (CAVEOLA)

Figure 7 in the manuscript 5 Additional fi le 3