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Promise – Spring 2004 Non-Profit Org. U.S. Postage PAID Permit No. 1112 Memphis, TN CHANGE SERVICE REQUESTED PromiseSpring 2004 332 N. Lauderdale St. Memphis, Tennessee 38105-2794 Public Information: 1-866-2STJUDE, ext. 3306 Jacob Simons’ Donations: 1-800-822-6344 Visit our Web site at www.stjude.org. Inner Vision St. Jude Children’s Research Hospital, American Lebanese Syrian Associated Charities and ALSAC are registered trademarks. Page 4 Promise is a quarterly publication of the St. Jude Children’s Research Hospital was founded by the late Department of Public Relations St. Jude Children’s Research Hospital 332 N. Lauderdale St. PromiseA publication of St. Jude Children’s Research Hospital Spring 2004 entertainer Danny Thomas. It opened February 4, 1962. The institution was created because Memphis, Tennessee 38105 St. Jude Children’s Research Hospital’s of a promise Danny made during the depression era to St. Jude Thaddeus, the patron saint mission is to find cures for children with Features catastrophic diseases through research and treatment. 3 Windows of Opportunity of the hopeless. From washing panes to alleviating pain Hospital Director Arthur W. Nienhuis, MD 4 Inner Vision ALSAC National Executive Director St. Jude patient Jacob Simons “Show me my way in life,” Danny prayed. In return, Danny promised to build St. Jude Richard C. Shadyac ALSAC/St. Jude 8 Staying Alive Senior Vice President of Thaddeus a shrine. That shrine became a world-class research institution that treats Long-term survivors of HIV Communications and Public Relations children regardless of race, color, creed or their ability to pay. This remarkable event also Jerry Chipman 12 Computing Cures at Super Speed Director of Public Relations Saving lives with the help of a supercomputer inspired the name of this magazine, Judith W. Black ALSAC Vice President of Communications 14 A Shared Vision George Shadroui Finding new treatments for retinoblastoma Promise. Publications Manager and Editor Elizabeth Jane Walker 17 Flipping Through the Pages of a Life Art Director Scrapbooking as therapy Jessica W. Anderson Photo Editor Jere Parobek 20 Bench to Bedside Reaping the benefits of research Photographers Seth Dixon Laura Hajar Ann-Margaret Hedges 22 A Sound Contribution Pensacola News Journal Promesa y Esperanza Contributing Writers Tanuja Coletta Joe Hanna Highlights Alicia H. Matthews Victoria Tilney McDonough 2 Achievements and Events Carrie L. Strehlau Guest Author Jimmy Naifeh Perspective Editorial Advisory Board 24 Jimmy Naifeh Lisa Baker The Hope and the Promise Bonnie Cameron Leslie Davidson Pat Flynn, MD Mark Hendricks Marc Kusinitz, PhD Phil McCarty Carlos Rodriguez-Galindo, MD Penny Tramontozzi St. Jude Children’s Research Hospital is an equal-opportunity employer. For inquiries about stories in this David Tucker publication, call the Public Relations department at (901) 495-2125 or e-mail Sally Wiard [email protected]. Visit our Web site at www.stjude.org/media. Articles and photos may be St. Jude Children’s Research Hospital, Memphis, Tennessee John Zacher reprinted with permission. ©2004. On the cover: Jacob Simons (see article, page 4). Photo by Seth Dixon. Highlights Avian flu making the protein a versatile tool for St. Jude Developmental Neurobiology. For the second winter in a row, the completing different tasks. Vinculin Baker is senior author of a report on this world’s medical and scientific communi- enables cells to move within developing study that appeared in Proceedings of the ties turned to experts at St. Jude for help tissues and organs of the embryo and National Academy of Sciences. we made a visit to the hospital,” Mike during a global crisis. Robert Webster, spark the healing of wounds. But vinculin The anti-cancer drug, CCI-779, is says. “It was more than we expected PhD, and his colleagues at St. Jude spent can also regulate the ability of cancer undergoing clinical trials for the treatment of a children’s hospital. To meet several months studying the H5N1 “bird cells to move away from tumors and of cancer. Baker says the findings have the staff and see the kids in person flu” outbreak in Asia. Webster worked spread cancer to other parts of the body, direct relevance to understanding the bio- WINDOWS convinced me that our donations with officials there to make recommenda- according to Tina Izard, PhD, of St. Jude logical basis of a variety of human disor- were meaningful.” tions about stopping the spread of this Hematology-Oncology. ders caused by Pten deficiency. The Gurnicks are proud of what disease, which sickened thousands of Izard led the research team and is the of they are doing to help the children at birds and killed individuals in Thailand first and senior author of a report on this St. Jude, and they encourage others to and Vietnam. work, which was published in the January Poisoning cancer cells OPPORTUNITY do the same. In late January 2004, the World Health 2004 issue of Nature. St. Jude investigators have discovered “St. Jude takes patients whether BY ALICIA H. MATTHEWS Organization (WHO) sent samples of how an enzyme crucial to the cell’s ability they can pay or not,” says Mike. “If the the avian flu virus from Vietnam to to decode genes and duplicate chromo- families have insurance, they’ll take it, St. Jude, where scientists began creating AAAS Fellow somes can be turned into a poison inside but if not, they take care of the chil- a vaccine against this strain of the bird James Downing, MD, chair of cancer cells. dren anyway. flu. Webster directs WHO’s U.S. Pathology at St. Jude, has been awarded The discovery is an important step “It’s a good feeling when you know Collaborating Center at St. Jude. Using the distinction of Fellow in the American toward designing a new class of anti- Mike and Mary Gurnick meet Nobel you are helping kids get well.” a reverse genetics system devised at Association for the Advancement of cancer drugs. Such drugs might be given laureate Peter Doherty, PhD, during a A charitable gift annuity allows tour of St. Jude. From washing panes to St. Jude, scientists in Webster’s Science (AAAS). Election as an AAAS with an existing agent that targets this donors to receive a fixed income for laboratory began creating a new strain Fellow is an honor bestowed upon mem- enzyme, creating a one-two punch against alleviating pain—Mike life in exchange for the transfer of cash that could be used as the master seed for bers by their peers. solid tumors and leukemia. The enzyme, ike W. Gurnick is a man or marketable securities. The fixed vaccine manufacturing. Fellows in AAAS have been elevated topoisomerase 1 (Top 1), is crucial to who commits to whatever and Mary Gurnick are payment rate is based solely on the age In response to the crisis, Webster to the rank because of their efforts to the cell’s ability to unwind the DNA of M task he decides to accom- of the beneficiary. With a charitable and Richard Webby, PhD, both of advance science or applications that are chromosomes and separate the two plish, including a 58-year span as an now using their talents gift annuity, the donor may specify St. Jude Infectious Diseases, were inter- deemed scientifically or socially distin- strands making up a giant molecule. industrial window washer. What began whether to receive an immediate annu- viewed by reporters from major media guished. As part of the Section on This activity permits the cell to decode as a part-time job turned into a lucra- and resources to help ity, with payment to begin not later outlets, including Time and Newsweek Medical Sciences, Downing was elected specific genes or to make a copy of the tive career, and at the age of 84, Mike than one year from the date of the gift, magazines, NBC Nightly News, ABC AAAS Fellow for elucidating the function entire chromosome. is still proudly working a few days the children of St. Jude. or a deferred gift annuity, from which World News Tonight, BBC (London), of the AML1/ETO transcript and its genes “We showed that modifying Top 1 so each week. payments are not to begin before a The Discovery Channel, The New York in normal and leukemic cells. it became locked onto the DNA molecule But that’s not where his work ends. specified future date. Times, The Wall Street Journal and is enough to cause cell death,” said Mary- Although Mike’s job keeps him busy, The Washington Post. Ann Bjornsti, PhD, of St. Jude Molecular he and his wife, Mary, also make time Research Hospital and have donated to New drug and Pten Pharmacology. Bjornsti is senior author of to help improve the lives of others. the hospital for almost 10 years. To learn more about Investigators at St. Jude used an exper- a report on this work, published in the Married for more than 50 years, the The Gurnicks were donors to Vinculin and cancer cells imental anti-cancer drug to prevent or November 2003 Proceedings of the Gurnicks hold a special place in their St. Jude before ever visiting the hospi- charitable gift annuities and St. Jude scientists have discovered reverse abnormal brain cell growth that is National Academy of Sciences. hearts for children. Mike is a member tal, but it was during one special visit how a protein called vinculin undergoes caused by lack of the anti-cancer gene of the American Legion, a community that they met Peter Doherty, PhD, a other ways to give, call the exquisitely precise changes in its shape. Pten. The study demonstrated that the run- These recent news items reflect service organization that supports St.
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