Financial Section 79 Annual Report 2012 investment Percentage of Percentage 1.5% 1.5% Other institutions 4.3% 4.3% investors Foreign 0.4% 0.4% Securities firms Financial institutions of shares Thousands 0.8% 2,1202,0651,994 2.4 1,984 2.4 2.3 2.3 4,7563,7763,456 5.5 3,310 4.3 2,717 4.0 3.8 3.1 11,424 13.1% Number of shares held shares 93.0% Individual investors 0.0% Treasury stock Treasury Santen Pharmaceutical Co., Ltd. Breakdown of shareholding by number of shares by of shareholding Breakdown 0.4% Securities firms 0.0% 0.0% stock Treasury 13.9% Other institutions 35.0% Financial institutions % 10.4 10/4 11/4 12/4 10/4 11/4 12/4 40.3% Foreign investors Breakdown of Shareholding Breakdown Major Shareholders Individual investors Breakdown of shareholding Breakdown The Bank of Tokyo-Mitsubishi UFJ, Ltd. The Bank of Tokyo-Mitsubishi and Custody Services Bank, Ltd. Trust Clients Omnibus Mellon Bank Treaty RBC Dexia Investor Services Trust, London Lending Account Name Services Bank, Ltd. Trustee Mita Sangyo Co., Ltd. Company 505223 Bank and Trust State Street Bank of Japan, Ltd. The Master Trust Development Bank of Japan Inc. Nippon Life Insurance Company 2012 3,655 2,778 09/4 09/4 million 08/4 08/4 Santen Pharmaceutical Co., Ltd. Santen Pharmaceutical 3-chome, 9-19, Shimoshinjo Higashiyodogawa-ku, Japan 533-8651, URL: http://www.santen.com contact: Investor relations TEL: +81-6-6321-7007 E-MAIL: [email protected] and Banking Corporation Mitsubishi UFJ Trust 6-3, Fushimi-cho 3-chome, Chuo-ku, Osaka 541-8502, Japan and Fukuoka Nagoya, Osaka Sendai, Tokyo, (Yen) 2008 2009 2010 2011 (Thousands of shares) okyo stock price index 1 TOPIX ces 07/4 07/4

1. TOPIX: T 0 0

4,000 3,000 2,000 1,000 Yearly High and Low Prices Yearly Trading Volume Volume Trading Stock Price Range 9,000 6,000 3,000 12,000 High (yen) 3,050 end of June. for the period to the Note: Calendar years. Stock prices for 2012 are 3,340 3,195 3,445 Low (yen) 2,125 2,460 2,694 2,731 8,288 Number of Shareholders Stock Exchange Listings and Osaka Tokyo Ticker Code 4536 Agent Transfer Corporate Headquarters Established 1890 Paid-in Capital ¥6,695 Major Offi Manufacturing Plants Shiga and Osaka Noto, Laboratory Research Number of Employees and Development Center Nara Research 1,927) 3,053 (non-consolidated: Issued 87,146,803 Number of Shares Osaka Securities Exchange (monthly basis) Osaka Securities Exchange (monthly basis)

As of March 31, 2012 31, As of March Corporate Information / Stock Information / Stock Information Corporate Business Bases As of August 2012

Plants and Laboratory

Noto Plant Shiga Plant Tampere Plant 2-14, Shikinami, Houdatsushimizu-cho, 348-3, Aza-suwa, Oaza-shide, Taga-cho, Niittyhaankatu 20, P.O. Box 33, Hakui-gun, Ishikawa 929-1494, Japan Inukami-gun, Shiga 522-0314, Japan FIN-33721 Tampere, TEL: +81-767-29-2666 FAX: +81-767-29-4233 TEL: +81-749-48-2900 FAX: +81-749-48-2901 TEL: +358-3-284-8111 FAX: +358-3-318-1900

Suzhou Plant Nara Research and Development Center No. 169 Tinglan Road, Suzhou Industrial Park, 8916-16, Takayama-cho, Ikoma-shi, Nara Note: Osaka Plant details have been omitted due to the Jiangsu Province 215026, P.R.C. 630-0101, Japan planned transfer of its operations to the Shiga TEL: +86-512-6295-7500 FAX: +86-512-6295-7800 TEL: +81-743-79-4501 FAX: +81-743-79-4521 Plant by the end of fiscal 2012.

80 Santen Pharmaceutical Co., Ltd. Annual Report 2012 Equity Corporate Headquarters and Subsidiaries Business Ownership

9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Research, development, production, Corporate Headquarters Osaka 533-8651, Japan marketing of pharmaceuticals and TEL: +81-6-6321-7000 FAX: +81-6-6328-7395 medical devices

348-3, Aza-suwa, Oaza-shide, Taga-cho, Inukami-gun, Cleaning of antidust and Claire Co., Ltd Shiga 522-0314, Japan 100% sterilized clothing TEL: +81-749-48-2234 FAX: +81-749-48-2239

Holding company for 2100 Powell Street, Suite 1600, Emeryville, Santen Holdings U.S. Inc. North American businesses and 100% California 94608, U.S.A. business development

2100 Powell Street, Suite 1600, Emeryville, Clinical development of Santen Inc. California 94608, U.S.A. pharmaceuticals and 100%1 TEL: +1-415-268-9100 FAX: +1-510-655-5682 business development

5743 Thornwood Drive, Goleta, California 93117, U.S.A. Development, production, Advanced Vision Science, Inc. 100%1 TEL: +1-805-683-3851 FAX: +1-805-964-3065 marketing of medical devices

Herikerbergweg 238, Centralization of financial controls Santen Holdings EU B.V. 100% 1101CM Amsterdam Zuidoost, for European operations

Niittyhaankatu 20, P.O. Box 33, Production, marketing, clinical Santen Oy FIN-33721 Tampere, Finland 100% development of pharmaceuticals TEL: +358-3-284-8111 FAX: +358-3-318-1900

1 rue Pierre Fontaine, Genavenir IV, Clinical development, Novagali Pharma S.A.S. F-91058 Evry cedex, 100% marketing of pharmaceuticals TEL: +33-1-69-87-40-20 FAX: +33-1-69-87-40-30

Erika-Mann-Strasse 21 80636 Munchen, Marketing of pharmaceuticals, Santen GmbH 100% TEL: +49-89-848078-0 FAX: +49-89-848078-60 business development Business Bases

Solna torg 3, SE-17145 Solna, SantenPharma AB Marketing support of pharmaceuticals 100% TEL: +46-8-83-4140 FAX: +46-8-83-4145

No. 169 Tinglan Road, Suzhou Industrial Park, Production, marketing, clinical Santen Pharmaceutical () Co., Ltd. Jiangsu Province 215026, P.R.C. 100% development of pharmaceuticals TEL: +86-512-6295-7500 FAX: +86-512-6295-7800

3F, Seocho G-WELL Tower, 1678-4, Seocho-dong, Santen Pharmaceutical Korea Co., Ltd. Seocho-gu, Seoul 137-070, Korea Marketing of pharmaceuticals 100% TEL: +82-2-754-1434 FAX: +82-2-754-2929

16F, No. 57, Sec. 2, Tun-Hwa South Rd., Taipei, R.O.C. Marketing, clinical development of Santen Pharmaceutical Co., Ltd. 100% TEL: +886-2-2700-1553 FAX: +886-2-2700-1730 pharmaceuticals

No. 216, Raheja Chambers, 12 Museum Road, 99.9% Santen Private Limited Bangalore 560 001, India Pharmaceutical market research 0.1%1 TEL: +91-80-4932-3700 FAX: +91-80-4932-3799

1. Indirect investment through Santen Holdings U.S. Inc.

Other Office

Suit 1206B, TOWER W3, Oriental Plaza, No. 1, Beijing Representative Office East Chang An Ave., Dong Cheng District, Beijing 100738, P.R.C. TEL: +86-10-8515-1515 FAX: +86-10-8515-1020

Santen Pharmaceutical Co., Ltd. Annual Report 2012 81