CLEC10A Recombinant Cat. No.: 91-524

CLEC10A Recombinant Protein

Specifications

SPECIES: Human

SOURCE SPECIES: Human Cells

SEQUENCE: Gln61-His316

FUSION TAG: C-6 His tag

TESTED APPLICATIONS:

APPLICATIONS: This recombinant protein can be used for biological assays. For research use only.

PREDICTED MOLECULAR 29.8 kD WEIGHT:

Properties

Greater than 95% as determined by reducing SDS-PAGE. PURITY: Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

PHYSICAL STATE: Lyophilized

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not BUFFER: recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

September 24, 2021 1 https://www.prosci-inc.com/clec10a-recombinant-protein-91-524.html Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. STORAGE CONDITIONS: Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Additional Info

OFFICIAL SYMBOL: CLEC10A

C-Type Domain Family 10 Member A, C-Type Lectin Superfamily Member 14, ALTERNATE NAMES: Macrophage Lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML

ACCESSION NO.: Q8IUN9

PROTEIN GI NO.: 929654682

GENE ID: 10462

Background and References

C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope on Marburg and Ebola viruses and enhances viral BACKGROUND: entry and infectivity. It constitute a unique class of C-type because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 .

ANTIBODIES FOR RESEARCH USE ONLY.

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September 24, 2021 2 https://www.prosci-inc.com/clec10a-recombinant-protein-91-524.html