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Mishpacha-Article-February-2011.Pdf
HANGING ON BY A FRINGCOLONE:EL MORDECHAI FRIZIS’S MEMBERS COURAG THEEOUS LA SRESPONSET ACT OF THE TRIBE? FOR HIS COUNTRY OPEN MIKE FOR HUCKABEE SWEET SONG OF EMPATHY THE PRESIDENTIAL HOPEFUL ON WHAT FUELED HIS FIFTEENTH TRIP TO ISRAEL A CANDID CONVERSATION WITH SHLOIME DACHS, CHILD OF A “BROKEN HOME” LIFEGUARD AT THE GENE POOL HIS SCREENING PROGRAM HAS SPARED THOUSANDS FROM THE HORROR OF HIS PERSONAL LOSSES. NOW DOR YESHORIM’S RABBI YOSEF EKSTEIN BRAVES THE STEM CELL FRONTIER ON-SITE REPORT RAMALLAHEDUCATOR AND INNOVATOR IN RREALABBI YAAKOV TIME SPITZER CAN THES P.TILLA. FORM LIVA FISCESALLY RSOUNDAV STATE?WEI SSMANDEL’S WORDS familyfirst ISSUE 346 I 5 Adar I 5771 I February 9, 2011 PRICE: NY/NJ $3.99 Out of NY/NJ $4.99 Canada CAD $5.50 Israel NIS 11.90 UK £3.20 INSIDE The Gene Marker's Rabbi Yosef Ekstein of Dor Yeshorim Vowed that No Couple Would Know His Pain Bride When Rabbi Yosef Ekstein’s fourth Tay-Sachs baby was born, he knew he had two options – to fall into crushing despair, or take action. “The Ribono Shel Olam knew I would bury four children before I could take my self-pity and turn it outward,” Rabbi Ekstein says. But he knew nothing about genetics or biology, couldn’t speak English, and didn’t even have a high school diploma. How did this Satmar chassid, a shochet and kashrus supervisor from Argentina, evolve into a leading expert in the field of preventative genetic research, creating an Bride international screening program used by most people in shidduchim today? 34 5 Adar I 5771 2.9.11 35 QUOTES %%% Rachel Ginsberg His father, Rabbi Kalman Eliezer disease and its devastating progression, as Photos: Meir Haltovsky, Ouria Tadmor Ekstein, used to tell him, “You survived by the infant seemed perfect for the first half- a miracle. -
CARRIER SCREENING: POPULATION DIFFERENCES, STIGMA, and the SPECTER of Co-Authored with EUGENICS Stephen Pemberton Tay Sachs KEITH WAILOO, PH.D
CARRIER SCREENING: POPULATION DIFFERENCES, STIGMA, AND THE SPECTER OF Co-authored with EUGENICS Stephen Pemberton Tay Sachs KEITH WAILOO, PH.D. Disease Martin Luther King Jr. Professor Cystic Fibrosis RUTGERS UNIVERSITY Sickle Cell Disease DEPARTMENT OF HISTORY INSTITUTE FOR HEALTH, HEALTH CARE POLICY, AND AGING RESEARCH RESEARCH SUPPORTED BY: ETHICAL, LEGAL, AND SOCIAL ISSUES (ELSI) PROGRAM, NHGRI; and THE JAMES S. MCDONNELL FOUNDATION Lessons of the Past: • Balancing the screening interests of individuals, communities, and society? The importance of historical sensitivity and cultural competence among health practitioners who engage in screening • How to target screening to distinct populations? The challenge of “hidden” versus obvious subpopulations. One-size does not fit all; how screening relates to group values and concerns • In health care, knowing when screening is not the answer for some populations. Other goals: treatment and extension of life, relief. The importance of competent screening programs among populations whose group identities are invested in the maintenance of values that are distinctively different than that of the majority culture. TODAY: ONE HISTORICAL CASE STUDY (TAY-SACHS DISEASE), WITH SICKLE CELL DISEASE AND CYSTIC FIBROSIS AS BACKDROP CONTROVERSIES in CARRIER SCREENING, STIGMATIZATION, AND POPULATION – the case of sickle cell disease • LINUS PAULING 1968: “I have suggested that there should be tatooed on the forehead of every young person a symbol showing possession of the sickle cell gene or whatever other -
Carrier Screening Panels for Ashkenazi Jews: Is More Better? Jennifer R
March 2005 ⅐ Vol. 7 ⅐ No. 3 article Carrier screening panels for Ashkenazi Jews: Is more better? Jennifer R. Leib, MS1,2, Sarah E. Gollust, BA3,4, Sara Chandros Hull, PhD3,4, and Benjamin S. Wilfond, MD3,4 Purpose: To describe the characteristics of Ashkenazi Jewish carrier testing panels offered by US Laboratories, including what diseases are included, the labels used to describe the panels, and the prices of individual tests compared to the prices of panels for each laboratory. Methods: GeneTests (http://www.genetests.org) was searched for laboratories that offered Tay-Sachs disease testing. Information was obtained from laboratory web sites, printed brochures, and telephone calls about tests/panels. Results: Twenty-seven laboratories offered up to 10 tests. The tests included two diseases associated with death in childhood (Niemann-Pick type A and Tay-Sachs disease), five with moderate disability and a variably shortened life span (Bloom syndrome, Canavan disease, cystic fibrosis, familial dysautonomia, Fanconi anemia, and mucolipidosis type IV), and two diseases that are not necessarily disabling or routinely shorten the lifespan (Gaucher disease type I and DFNB1 sensorineural hearing loss). Twenty laboratories offered a total of 27 panels of tests for three to nine diseases, ranging in price from $200 to $2082. Of these, 15 panels cost less than tests ordered individually. The panels were described by 24 different labels; eight included the phrase Ashkenazi Jewish Disease or disorder and six included the phrase Ashkenazi Jewish Carrier. Conclusion: There is considerable variability in the diseases, prices, and labels of panels. Policy guidance for establishing appropriate criteria for inclusion in panels may be useful to the Ashkenazi Jewish community, clinicians, and payers. -
Illuminati Formula to Create a Mind Control Slave
The Illuminati Formula to Create an Undetectable Total Mind Control Slave Dedication & Table of Contents Fritz Springmeier's Introduction Glossary of Terms By Fritz Springmeier & Cisco Wheeler http://educate-yourself.org/mc/IlluminatiFormulaindex.shtml Dedication This book is dedicated to the two million Americans and counting who have been programmed with Monarch-type trauma-based mind control. This book is written to destroy trauma-based mind control before it destroys the human race. It’s time for this horrendous secret to end. It is also written as part of God’s end time work to propel people of faith to the high calling that is prophesied of the Body, but cannot be attained without men of faith understanding these things. Humanity’s great prophet said he came to heal those whose hearts had been broken-- literally split and crushed, and to free those who are captive. That work needs to go forward. Blood, sweat and tears are associated with this book. The blood of the innocent victims of this mind- control cries out in a single unison, along with the pungent sweat of those who have tried to minister help to the shattered humanity left by the sadistic programmers, and the pools of tears shed as this book was written, "How long, O Lord, holy and true, do you not judge and avenge our blood on earth?" WARNING, READ THIS FIRST BEFORE READING THE BOOK: IF THERE IS ANY CHANCE you the reader have had mind-control done to you, you must consider the following book to be DANGEROUS. If you are consulting a therapist for DID (also known as MPD), it is recommended that you consult your therapist before reading this book. -
Judaism, Genetic Screening and Genetic Therapy Part 2
Jerusalem Science Contest החידון המדע הירושלמי Judaism, Genetic Screening and Genetic Therapy Part 2 The Jerusalem Science contest lecture on Judaism, Genetic Screening and Genetic Therapy – Part 2 1 Judaism, Genetic Screening and Genetic Therapy FRED ROSNER, M.D., F.A.C.P. OCTOBER/NOVEMBER 1998 NUMBER 5 & 6 VOLUME 65:406-413 From the Director, Department of Medicine, Mount Sinai Services at Queens Hospital Center, Jamaica, NY, and Professor of Medicine, Mount Sinai School of Medicine, New York, NY. Address correspondence to Fred Rosner, M.D., F.A.C.P., Queens Hospital Center, 82-68 164th Street, Jamaica, NY 11432 or address e-mail to: [email protected] Presented at the 8th annual International Conference on Jewish Medical Ethics. San Francisco, CA, February 15, 1997. Fred Rosner, M.D., F.A.C.P., Professor of Medicine at Mount Sinai School of Medicine, currently serves as the Director, Department of Medicine, Queens Hospital Center in New York City. Dr. Rosner, an internationally known authority on medical ethics, is the founding and former Chairman of the Medical Ethics Committee of the Medical Society of the State of New York and is the former Co-Chairman of the Medical Ethics Committee of the Federation of Jewish Philanthropies of New York. Dr. Rosner, a prolific writer, is the author of widely acclaimed books and articles on Jewish medical ethics and Jewish medical history. He also serves as a reviewer and editor for many medical journals. In part 2, we continue to review a presentation and essay by Dr. Fred Rosner delivered on February 15, 1997 at the 8th annual Conference on Jewish Medical Ethics, San Francisco, California. -
JEWISH OBSERVER {ISSN) Ool!J-6Gl5 LS Pllbusih:O MO"Itllly J.:XCF.L't J111.Y & Allg!IST by !"!IE AGUOATH IS RAEL of AMERICA 4\! L~ROAOWAY, NEW YORK, NY !OOOJ
• The ribbon, It's America's symbol for an urgent cause. first, there were pink ond purple ribbons to support medical research. Then, as our brave troops departed for distant shores, the yellow ribbons, and the red, white and blue, appeared everywhere. To that, we add the green Cucumber ribbon to support our kin.111 troops fighting for Ooroh's vital cause - saving Jewish neshamos. So display your green ribbon with pride. It's another important way to show you care. 1. • To get your free Cucumber ribbon dial extension 6038. f you were one of the 100.000+ participants at the Eleventh Siyum HaShas of Oaf Yomi here is your chance to relive that unforgettable expe Irience through a collection of CD ROMs. capturing all of the inspiring moments of the Siyum. f you were not fortunate to attend. you can now feel that awesome expe rience by seeing and hearing the inspiring words of our gedolim. and Icapture the excitement that so many witnessed and enjoyed. This commemorative five CD ROM set encased in an attractive customized binder. has been produced by popular request and is available for $39. 99 per set (plus $5.00 per set postage and handling.) Order Now! You'll treasure this historic event for years to come. An excellent gift item - order extra sets for friends and family! To: OAF YDMI COMMISSION • AGUDATH ISRAEL OF AMERICA • 42 Broadway. New York. NY 10004 Please send me set(s) of the Eleventh Siyum HaShas of Dal Yomi Commemorative CD ROM set. Iam enclosing a contribution of $39.99 for each set ordered • (plus $5.00 per set for postage and handling [USA addresses only]). -
Blood of the Innocent People I They Regin Fire of War Set a Greet Confie
the "blood of the innocent people I They regin fire of war set a greet confie gre t ton, tc such on ex+ent that ell the 3 el ken nations arose i n enmity ag£inr + each o^her, totelly disregarding the inviolable rights of men* Even now they ere not calmed down. ’’How oonpi dor clearly the woeful results of polities! prejudices.' CcnF.ecier.tlv we must o h m entirely *hese prejudices r ni rv’teh hi ph the tent of the Oneness of tpe world of humanity and cement the hearts together* Per chance mankind may lighten its lords r nd start on the read of pec J fi cat i oû 7/ere the Tea chings of Babe,’o’Ha h universnlly spread in Europe, all these opnresci or.s , blood-nhed, cruelty, rapacity, hostility and avers 1 on would have been removed- Then all the Kftnin±*:ftrx*i®*y»fy*>*yiij»iijrp3r people would become the sheep of God, a nfl enter under th® benevolent admin3stration of the Heavenly Shepherd* The Keys of Reality would shine -Forth, dispelling the impenetrable darkness of race antipathy and antagonism. "Therefore, strive ye with all your hearts and souls, so that ye may render service to the oneness of the world of human.1 ty; thus e ternol life mpfr be obtai ned and the. heads be crowned with tpe diadem of Everlasting Glory* * - - - - - Another Tablet, to a believer in Vienna, is as follows:- ”0 thou daughter of the Hingdon] The good news of the organiza tion of the Bahai Assembly in ■'Vienna, was received- Although this Assembly is limited at this time to a sna.1! number of souls, yet it is a Bivine Assembly, and therefore i*B circle rill be enlarged day unto day like unto the Assembly of +h« Lord’s Supper of His Holiness Christ, and its influence shall be felt in a?.! parts of the world. -
Fuzzy Logic and Preconceptional Genetic Carrier Screening-Revised
Issue 1/2014 2341-0183 Fuzzy%Logic%and%Preconceptional%Genetic% Carrier%Screening! ! Julia&Inthorn1! 1!Institute!for!Medical!Ethics!and!History!of!Medicine,!Göttingen!University!Medical!Centre,!Germany! and!Centre!for!Research!Ethics!and!Bioethics,!Uppsala!University,!Sweden! ! Email:[email protected]! Abstract Medical(screening(programs(have(been(established(based(on(the(idea(of(early(treatment(and( prevention.( The( selection( of( tests( as( well( as( the( diseases( tested( for( that( are( included( in( a( screening( need( to( be( ethically( justified.( This( article( looks( at( criteria( for( screening( such( as( severity( of( a( disease( and( efficiency( of( a( test( and( their( applicability( for( newly( developed( preconceptional( genetic( carrier( screening.( Preconceptional( genetic( carrier( screening( can( be( used(by(couples(planning(a(pregnancy(in(order(to(learn(it(they(are(both(carriers(of(a(recessive( inherited(diseases(und(thus(have(an(increased(risk(of(having(an(affected(child.(It(is(argued(that( introducing( fuzzy( logic( helps( to( overcome( a( binary( logic( of( ethical( decisions( and( to( discuss( ethical( problems( connected( to( the( selection( of( diseases( for( preconceptional( genetic( carrier( screening( in( a( more( nuanced( way.( With( ongoing( research( about( the( relationship( between( genotype(and(phenotype(as(well(as(current(development(of(new(genetic(screening(methods(the( selection(of(tests(and(diseases(will(have(to(deal(with(knowledge(deficits(which(fuzzy(logic(can( help(to(handle.((( Submitted:!20/02/14.!Accepted!and!Published:!29/04/14 !Inthorn: Fuzzy Logic and Preconceptional! ! Genetic! Carrier Screening! !! APHSC 1:2014 DOI tbp – http://www.aphsc.org Page 1 of 10 © 2014 by the Authors; licensee ECSC. -
Optional Ashkenazi Panel Brochure
בס’’ד Fulfilling Our Responsibility To The Next Generation A VITAL PROGRAM THAT SAVES LIVES! The Dor Yeshorim mission: For over 30 years, Dor Yeshorim has successfully prevented the occurrence of genetic diseases in our NOW AVAILABLE: families. Since 1983, Dor Yeshorim with Hashem’s help NEW PANEL OF TESTS has successfully prevented genetic diseases from affecting our Jewish Community by conducting mass screenings in high schools, colleges, universities, FOR SEVEN ADDITIONAL yeshivas and seminaries worldwide- throughout the United States, Israel, Canada, Europe, and countless other orthodox Jewish communities. DEVASTATING AND The Dor Yeshorim genetic screening program was established to provide protection from Jewish genetic diseases, while safeguarding individuals from the potentiallY FatAL psychological stigma associated with knowing their carrier status. DISEASES To date, approximately 375,000 individual genetic screening tests have been performed, and nearly 2,000 potential couples have been spared the List of Diseases: agony of giving birth to a child or children with a 1. Bardet–Biedl Syndrome Type 2 (BBS2) devastating or fatal genetic disease. The birth of a sick child not only impacts the parents of this child 2. Nemaline Myopathy (NM) but also the siblings, grandpare nts and the extended 3. Dihyrolipoamide Dehydrogenase Deficiency (DLDD) family. B’H Dor Yeshorim has been able to spare over 4. Usher Syndrome Type 1 (USH1) 2,000 families the hardships associated with having such a child. 5. Joubert Syndrome (JBTS) DY benefits from -
The Anarchists: a Picture of Civilization at the Close of the Nineteenth Century
John Henry Mackay The Anarchists: A Picture of Civilization at the Close of the Nineteenth Century 1891 The Anarchist Library Contents Translator’s Preface ......................... 3 Introduction.............................. 4 1 In the Heart of the World-Metropolis .............. 6 2 The Eleventh Hour.......................... 21 3 The Unemployed ........................... 35 4 Carrard Auban ............................ 51 5 The Champions of Liberty ..................... 65 6 The Empire of Hunger........................ 87 “Revenge! Revenge! Workingmen, to arms! . 112 “Your Brothers.” ...........................112 7 The Propaganda of Communism..................127 8 Trafalgar Square ...........................143 9 Anarchy.................................153 Appendix................................164 2 Translator’s Preface A large share of whatever of merit this translation may possess is due to Miss Sarah E. Holmes, who kindly gave me her assistance, which I wish to grate- fully acknowledge here. My thanks are also due to Mr. Tucker for valuable suggestions. G. S. 3 Introduction The work of art must speak for the artist who created it; the labor of the thoughtful student who stands back of it permits him to say what impelled him to give his thought voice. The subject of the work just finished requires me to accompany it with a few words. *** First of all, this: Let him who does not know me and who would, perhaps, in the following pages, look for such sensational disclosures as we see in those mendacious speculations upon the gullibility of the public from which the latter derives its sole knowledge of the Anarchistic movement, not take the trouble to read beyond the first page. In no other field of social life does there exist to-day a more lamentable confusion, a more naïve superficiality, a more portentous ignorance than in that of Anarchism. -
Finding Utility for Genetic Diagnostics in the Developing World
Finding Utility for Genetic Diagnostics in the Developing World By Ridhi Tariyal B.S. Industrial Engineering, Georgia Institute of Technology (2002) M.B.A. Harvard Business School (2009) SUBMITTED TO THE HARVARD - MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREES OF MASTERS OF SCIENCE IN HEALTH SCIENCES AND TECHNOLOGY ARCHNES at the 4ASSACHUETFS ONS ITUTEj OF TFc, ooG MASSACHUSETTS INSTITUTE OF TECHNOLOGY MAR 9 1 2 11 September 2010 L @2010 Ridhi Tariyal. All rights reserved. IRARIES The author hereby grants MIT permission to reproduce and distribute publicly paper and electronic copies of thisthesis document in whole or in part. Signature of Author:"' H ard-MIT Division of Health $ciences and Technology, August 2010 Certified by: George Church Professor of Ge tics, Harvard Medical School, Director of the Center for Computational Genetics Thesis Supervisor Certified by: -Z-_==: - - Stan Lapidus Senior Lecturer, MIT Sloan School of Management Thesis Supervisor Accepted by: Ram Sasisekharan, PhD/Director, Harvard-MIT Division of Health Sciences and Technology/Edward Hood Taplin Professor of Health Sciences & Technology and Biological Engineering. ACKNOWLEDGEMENTS The idea behind this thesis was born in 2006 when I was working for a big pharmaceutical company and reading about the progress in genetics. I found myself spending more time thinking about the advances and challenges in the personalized medicine space than the immediate tasks and challenges in my employment. Since then, it has been a pleasure to move slowly but surely towards aligning my personal interests with my academic and professional pursuits. I would like to thank my classmates in school, my wonderful professors and my friends and family for brainstorming with me, encouraging me, answering endless questions about very personal genetic choices and offering unwavering support in this journey. -
Dor Yeshorim
בס"ד Dor Yeshorim Fulfilling Our Responsibility to the Next Generation Dor Yeshorim, for over 26 years, has had one mission: premarital program is the best application of preventive medicine and the most successful application of genetic sciences to date, anywhere in the The total elimination of the occurrences of recessive genetic illnesses. world. To accomplish this mission, Dor Yeshorim utilizes a program that does no harm to participants, avoids their stigmatization, and is guided by halachah. The Dor Yeshorim program has become an integral part of the shidduch process in the Torah observant Ashkenazi Jewish community worldwide. Under the direction of Gedolei Yisroel and the world’s foremost medical Over 300,000 individuals have, since its inception, participated in the experts, Dor Yeshorim has managed to eliminate the incidence of Tay program, with over 22,000 individuals being screened and joining the Sachs disease, as well as other recessive genetic diseases common to the program every year. To date, more than 1,600 marriages of couples, where Ashkenazi Jewish community, while zealously guarding the privacy and both parties were carriers of a genetic mutation, and therefore risked having dignity of Jewish families. affected children, have been avoided. The impact of the Dor Yeshorim program is indisputable. After over 26 years Today it’s a given that a potential choson or callah doesn’t arrive at a of activity there are virtually no children born with Tay Sachs disease! This marriage decision without first ascertaining genetic suitability. Using the accomplishment is evidenced by the fact that Kingsbrook Medical Center, in Dor Yeshorim program can prevent disasters in future generations.