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Newsletteralumni News of the Newyork-Presbyterian Hospital/Columbia University Department of Surgery Volume 13, Number 1 Summer 2010
NEWSLETTERAlumni News of the NewYork-Presbyterian Hospital/Columbia University Department of Surgery Volume 13, Number 1 Summer 2010 CUMC 2007-2009 Transplant Activity Profile* Activity Kidney Liver Heart Lung Pancreas Baseline list at year start 694 274 174 136 24 Deceased donor transplant 123 124 93 57 11 Living donor transplant 138 17 — 0 — Transplant rate from list 33% 50% 51% 57% 35% Mortality rate while on list 9% 9% 9% 15% 0% New listings 411 217 144 68 23 Wait list at year finish 735 305 204 53 36 2007-June 2008 Percent 1-Year Survival No % No % No % No % No % Adult grafts 610 91 279 86 169 84 123 89 6 100 Adult patients 517 96 262 88 159 84 116 91 5 100 Pediatric grafts 13 100 38 86 51 91 3 100 0 — Pediatric patients 11 100 34 97 47 90 2 100 0 — Summary Data Total 2009 living donor transplants 155 (89% Kidney) Total 2009 deceased donor transplants 408 (30% Kidney, 30% Liver) 2007-June 2008 adult 1-year patient survival range 84% Heart to 100% Pancreas 2007-June 2008 pediatric 1-year patient survival range 90% Heart to 100% Kidney or lung *Health Resource and Service Administration’s Scientific Registry of Transplant Recipients (SRTR) Ed Note. The figure shows the US waiting list for whole organs which will only be partially fulfilled by some 8,000 deceased donors, along with 6,600 living donors, who will provide 28,000 to 29,000 organs in 2010. The Medical Center’s role in this process is summarized in the table, and the articles that follow my note expand on this incredible short fall and its potential solutions. -
Hearts with Cardiac Arrest History Safe for Transplant in the Context Of
Yale University EliScholar – A Digital Platform for Scholarly Publishing at Yale Yale Medicine Thesis Digital Library School of Medicine January 2015 Hearts With Cardiac Arrest History Safe For Transplant In The onC text Of Donor And Recipient Factors Aditi Balakrishna Yale School of Medicine, [email protected] Follow this and additional works at: http://elischolar.library.yale.edu/ymtdl Recommended Citation Balakrishna, Aditi, "Hearts With Cardiac Arrest History Safe For Transplant In The onC text Of Donor And Recipient Factors" (2015). Yale Medicine Thesis Digital Library. 1945. http://elischolar.library.yale.edu/ymtdl/1945 This Open Access Thesis is brought to you for free and open access by the School of Medicine at EliScholar – A Digital Platform for Scholarly Publishing at Yale. It has been accepted for inclusion in Yale Medicine Thesis Digital Library by an authorized administrator of EliScholar – A Digital Platform for Scholarly Publishing at Yale. For more information, please contact [email protected]. Hearts With Cardiac Arrest History Safe For Transplant in the Context Of Donor And Recipient Factors A Thesis Submitted to the Yale University School of Medicine in Partial Fulfillment of the Requirements for the Degree of Doctor of Medicine by Aditi Balakrishna MD Candidate, Class of 2015 Yale School of Medicine Under the supervision of Dr. Pramod Bonde, Department of Surgery Abstract Background: Cardiac arrest, or downtime, can result in ischemic damage to myocardial tissue, which prompts caution in accepting hearts with such a history for transplant. Our aim is to provide guidance about whether these hearts are suitable and which among them confer optimal outcome. -
3Rd Annual Stanford Drug Discovery Conference April 23-34, 2018
WINTER 2018 SPRING 2017 3rd Annual Stanford Drug Discovery Conference April 23-34, 2018 Kenneth Frazier, JD Joe Jimenez, MBA Brent Saunders, JD, MBA Bob Bradway, MBA Patrick Soon-Shiong, MD George Scangos, PhD CEO, Merck Former CEO, Novartis CEO, Allergan CEO, Amgen CEO, NantWorks CEO, Vir Roy Vagelos, MD Janet Woodcock, MD Maria Millan, MD Gary Gibbons, MD Marc Tessier-Lavigne, PhD Brian Kobilka, MD Former CEO, Merck Director, FDA Center President, CIRM Director, NHLBI President Nobel Prize in for Drug Evaluation Stanford University Chemistry, 2012 and Research (CDER) Paul Yock Wins National Academy Faculty of Engineering’s Gordon Prize Recruitment Paul Yock, MD, professor of medicine and of bioengineering at Stan- The Cardiovascular Institute and the De- ford University, will receive the National Academy of Engineering’s partment of Medicine at Stanford Univer- 2018 Bernard M. Gordon Prize for Innovation in Engineering and Tech- sity are recruiting a full-time academic nology Education. faculty with expertise in any of the areas of drug/gene delivery, polymer chemistry/ The academy said Yock was chosen for “the development and global nanotechnology, bioengineering/bioma- dissemination of Biodesign, a biomedical technology training pro- terial sciences, biomedical formulation, Paul Yock, MD gram that creates leaders and innovations that benefit patients.” The clinical medicinal chemistry, medical phar- prize is the academy’s top honor for teaching and carries a $500,000 award. macology/molecular pharmacology, toxicol- Yock, who holds the Martha Meier Weiland Professorship and was the founding co-chair of ogy, bioinformatics, applied proteomics and Stanford’s Department of Bioengineering, is known for his work inventing and testing new pharmacogenomics at the rank of Assistant medical devices in the field of interventional cardiology. -
Download Autumn 2018
A PUBLICATION OF VCU HEALTH The Beat PAULEY HEART CENTER A U T U M N — 2 0 1 8 Coming Home Pauley Welcomes Dr. Greg Hundley as First Director It’s April, and Dr. Greg Hundley, VCU Health Pauley Heart Center’s fi rst-ever director, has started to move into his new offi ce in West Hospital. Around the room are stacks of boxes fi lled with books. A dry-erase board, not yet hung, leans against a wall. Continued VCU HEALTH PAULEY HEART CENTER 1 my desired research training,” he said. them to coronary angiograms. The research, “Research-wise, I had the distinct opportunity published by the American Heart Association, About to work with Dr. Hermes Kontos as well as gained significant international attention. He Drs. Joseph Levasseur, Enoch Wei and Joe also devised protocols for the use of MRIs Dr. Hundley Patterson.” in creating images of coronary arteries that Hundley felt drawn to cardiovascular supplied the heart muscle. “Dr. Hundley is a nationally and internationally medicine after working in the cardiovascular During this time, his innovative work recognized leader in his area of research ICU. “The patients were relatively sick, and caught the attention of Dr. George Vetrovec, on the cardiac complications of cancer there was a lot of satisfaction in the care that the former chair of cardiology who retired in therapy. His ability to collaborate with faculty could be delivered in that environment to 2015. “We sat next to each other at a dinner at VCU Massey Cancer Center is already make them well.” of the Society for Cardiac Angiography demonstrated through our participation in his From 1988 to 1996, he completed and Intervention. -
Alternative Therapies for Orthotopic Heart Transplantation
Alternative Therapies for Orthotopic Heart Transplantation Daniel J. Garry, M.D., Ph.D. Medical Grand Rounds, Department of Internal Medicine July 19, 2001 Disclosure: This is to acknowledge that Daniel Garry, M.D., Ph.D. has not disclosed any financial interests or other relationships with commercial concerns related directly or indirectly to this program. Dr. Garry will be discussing off-label uses in his presentation. BIOGRAPHICAL INFORMATION: Daniel J. Garry, M.D., Ph.D. Assistant Professor, Departments of Internal Medicine, Molecular Biology UT Southwestern Medical Center INTERESTS: Congestive Heart Failure/Cardiac Transplantation Basic science mechanisms·of stem cell biology & oxygen metabolism 2 Congestive heart failure (CHF) Therapeutic strategies for heart failure have evolved tremendously over the past several hundred years. Treatment of congestive heart failure (CHF) or what was referred to as "dropsy" was aimed initially at restoring a balance of fundamental elements and humors. In 1683, Thomas Sydenham recommended bleeding, purges, blistering, garlic and wine. Additional treatments were attempted and abandoned after unrewarding anecdotal experiences (i.e. death). Progress regarding the treatment of heart failure was evident with the introduction of amyl nitrate, mercurial diuretics, digitalis glycosides and bed rest in the early 20th century. Medical therapy for heart failure in the 1960's included digitalis, thiazide diuretics (introduced in 1962) and furosemide (introduced in 1965). The utilization of vasodilators for heart failure were implemented in the 1970's (nitroprusside in 1974 and hydralazine in 1977) and the first large, randomized, clinical trial for heart failure was not completed until 1986 (V-HeFf 1). Since then, the design and completion of a number of large, randomized, placebo-controlled clinical trials have established angiotensin-converting enzyme inhibitors and B-adrenergic receptor antagonists as the cornerstones of therapy. -
Thoracic and Cardiovascular Surgery
GREAT INSTITUTIONS One Hundred Years of History at Stanford University: Thoracic and Cardiovascular Surgery Y. Joseph Woo, MD, and Bruce A. Reitz, MD The history of thoracic and cardiovascular surgery at Stanford spans a century long period, beginning not long after the founding of Stanford University. Pioneering Stanford surgeons have made landmark discoveries and innovations in pulmonary, transplantation, thoracic aortic, mechanical circulatory support, minimally invasive, valvular, and congenital heart surgery. Fundamental research formed the foundation underlying these and many other advances. Educating and training the subsequent leaders of cardio- thoracic surgery has throughout this century-long history constituted a mission of the highest merit. New Stanford Adult Hospital Semin Thoracic Surg 27:388–397 I 2015 Elsevier Inc. All rights reserved. Central Message Keywords: History, Cardiovascular Surgery, Thoracic Surgery, Transplantation, Aortic Dissection Stanford: Upon a foundation of rigorous scien- tific investigation and dedicated teaching, Stan- ford thoracic and cardiovascular surgeons PRE-STANFORD UNIVERSITY Stanford Faculty in pioneered discoveries and innovations in pul- Lineage tracing of the history of Stanford Cardiothoracic 1914 and led the monary, transplantation, aortic, minimally inva- Surgery could be extended back to 1857, even before the Stanford surgical sive, and congenital heart surgery. founding of Stanford University. Elias Samuel Cooper, a San service at the San Francisco surgeon, authored “Report of an Operation to Francisco General Hospital2 (Fig. 2). Although he practiced a Remove a Foreign Body from Beneath the Heart” published broad spectrum of surgery, much of his clinical and experimental by the San Francisco Medico Chirurgical Association. The work and scholarly publications were in the arena of chest following year in 1858, Cooper founded the first medical surgery. -
Cardiac Transplantation: Since the first Case Report
Grand Rounds Vol 4 pages L1–L3 Speciality: Landmark Case Report Article Type: Original Case Report DOI: 10.1102/1470-5206.2004.9002 c 2004 e-MED Ltd GR Cardiac transplantation: since the first case report S. M. Benjamin and N. C. Barnes Department of Respiratory Medicine, London Chest Hospital, London, United Kingdom Corresponding address: S M Benjamin, Department of Respiratory Medicine, London Chest Hospital, London, United Kingdom. E-mail: [email protected] Date accepted for publication 1 March 2004 Abstract Heart transplantation was and is still recognised as a medical milestone. Its ability to offer a second chance of life to people with end-stage cardiac disease is its major triumph. Dr Christiaan Barnard’s work was instrumental in realising the actual possibility of conducting a human transplant, and provided the framework for further advances in this field. He deserves due credit for conducting the first successful human heart transplant. Keywords Cardiac transplantation. Introduction Heart transplantation is one of the most widely publicised medical advances in the last century. Dr Christiaan Barnard accomplished this historic medical feat on December 3, 1967. The potentially life-saving operation immediately captured worldwide attention, lauding him with much deserved praise for his outstanding work in this field. Heart transplants Earlier experiments in heart transplantation were carried out in laboratories using canine models. As early as 1905, Alexis Carrel and Charles Guthrie [1, 2] first attempted transplanting the heart of a puppy into the neck of an adult dog. The heterotopic heart immediately resumed cardiac contractions lasting approximately 2 h. Dr Norman Shumway and Dr Richard Lower of Stanford University performed the first orthotopic heart transplant in 1960 applying principles of topical hypothermia for graft preservation and immunosuppression in order to prolong graft survival times. -
Norman Shumway
View metadata, citation and similar papers at core.ac.uk brought to you by CORE Baumgartner et al PRESIDENTIAL BIOGRAPHY Presidentialprovided by BiographyElsevier - Publisher Connector Norman E. Shumway, MD, PhD: Visionary, innovator, humorist William A. Baumgartner, MD,a Bruce A. Reitz, MD,b Vincent L. Gott, MD,a and Sara J. Shumway, MDc Born in Kalamazoo, Michigan, in 1923, Norman Edward sent back into the infantry. He then did three quarters of Shumway, Jr, and his parents (Laura Vandervliet Shumway premed at Baylor University in Waco, Texas. and Norman Edward Shumway, Sr) moved to Jackson, When it was time for Dr Shumway to matriculate to med- Michigan, when he was 1 year of age. His parents’ business ical school, all of the military slots were filled. He took an was operating ‘‘The Home Dairy,’’ which consisted of the interim job at Western State Mental Institution in Memphis, dairy in the back section and a diner up front. He went to Tennessee, where he was an orderly for 6 months. A slot be- the local grade school and was influenced early in a potential came open at Vanderbilt University in 1945, where he career in medicine when one of his classmates died of appen- started medical school. At Vanderbilt he was influenced dicitis. At Jackson High School, Dr Shumway was active on by 2 prominent surgeons of the time: Dr Barney Brooks, the debate team. His team was highly successful and won the Chief of Surgery, and Dr Cobb Pilcher, Chief of Neurosur- Michigan state championship in his senior year and then gery. -
Newsletteralumni News of the Newyork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009
NEWSLETTERAlumni News of the NewYork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009 Outliers All requires several iterative improvements and sometimes a leap of faith to cross a chasm of doubt and disappointment. This process is far more comfortable and promising if it is imbued with cross- discipline participation and basic science collaboration. Eric’s early incorporation of internist Ann Marie Schmidt’s basic science group within his Department continues to be a great example of the pro- ductivity that accrues from multidiscipline melding. Several speakers explored training in and acceptance of new techniques. The private practice community led the way in training and early adoption of laparoscopic cholecystectomy, which rapidly supplanted the open operation, despite an early unacceptable inci- dence of bile duct injuries. Mini-thoracotomies arose simultaneous- ly at multiple sites and are now well accepted as viable approaches to the coronaries and interior of the heart; whereas, more than a de- cade after their introduction, video assisted lobectomies for stage I, non-small-cell lung cancer account for <10% of US lobectomies. Os- tensibly, this reluctance reflects fear of uncontrollable bleeding and not doing an adequate cancer operation, neither of which has been a problem in the hands of VATS advocates. The May 8, 2009, 9th John Jones Surgical Day was a bit of an Lesions that are generally refractory to surgical treatment, outlier because the entire day was taken up by a single program, ex- such as glioblastomas and esophageal and pancreas cancers merit cept for a short business meeting and a lovely evening dinner party. -
History of Heart Transplantation: a Hard and Glorious Journey
SPECIAL ARTICLE - HISTORIC Braz J Cardiovasc Surg 2017;32(5):423-7 History of Heart Transplantation: a Hard and Glorious Journey Noedir A. G. Stolf1, MD, PhD DOI: 10.21470/1678-9741-2017-0508 INTRODUCTION contractions were seen. Afterward contractions appeared and about an hour after the operation, effective contractions of This year we celebrate 50 years of the first interhuman heart the ventricles began. The transplanted heart beat at the rate of transplantation. So, I believe that it is interesting to review the 88 per minute, while the rate of the normal heart was 100 per most important steps of this glorious journey. minute. A little later tracing was taken. Owing to the fact that Heart transplantation first performed in the course of the operation was made without aseptic technique, coagulation experiments of other nature in the beginning of 20th century, occurred in the cavities of the heart after about two hours, and seen as a speculation for the future in the middle of the same the experiment was interrupted”. century, is now widely accepted by medical and lay communities Although the exact details of experiments were not known as a valuable therapeutic procedure. the most probable arrangement of anastomosis are shown in This history can be divided into an experimental and a Figure 1 adaptation in a book by Najarian and Simmons[2]. The clinical heart transplantation periods, with the first one in problem with this model is that arterial inflow is in the atrium heterotopic non-auxiliary, heterotopic auxiliary and orthotopic and aortic outflow is under venous pressure, in other words, transplantations. -
OSUMC PRESENTATION Template Jan2011
The ERA of Regulatory Oversight in Solid Organ Transplantation Does Your Program Have the Right Stuff? Disclosure Information . No financial conflicts to disclose. (I am as confused as you are) 2 UNOS is a… 1. Part of the federal government 52% 2. A contractor for transplant programs 43% 3. A trade organization 4. United Network of Surgeons 2% 2% 1 2 3 4 3 OPTN is… 1. Organ Procurement and 98% Transplant Network 2. A unionized labor program 3. State-run transplant program 4. Organ Processing Tissue Network 0% 0% 2% 1 2 3 4 4 SRTR reports… 1. Only to patients and recipients 80% 2. Makes policies governing transplant 3. Enforces the OPTN bylaws 4. Patient/organ survival after transplant 8% 8% 4% 1 2 3 4 5 Insurance contracts are based on… 1. Cost of transplant at center 94% 2. Length of stay 3. Quality metrics 4. Survival rates 5. All of the above 4% 0% 0% 2% 1 2 3 4 5 6 “The Right Stuff” The Key to Transplant Success in the Current Regulatory Environment . History-How did we get here? . Current regulatory requirements . OPTN/UNOS . CMS . Building a successful program . Quality assessment/Process Improvement (QAPI) 7 Iconic Role Models “ Ask the Question” Pharos,1982 Ravitch Starzl “We do not learn from Bahnson vain exultation of successes, but from “Be Brave” our failures.” Mens Room, Many Sleepless Nights PresbyHosp Pgh. 9 TRANSPLANTATION- Quality and Quantity of LIFE Transplant Success GOOD DONOR GOOD RECIPIENT GOOD OUTCOME The Regulatory oversight of Transplantation…it’s Alphabet Soup! Heart OPO Arm Lung SRTS UNOS Face CMS HRSA ACO NATO ACOTOPTN Hand NKF HHS NOTA Kidney AOPO DOT AST Liver Bone Marrow ASTS JCAHO Transplant History Fantastic Firsts in Our field 1968 1990 First Successful Heart Transplants in the U.S. -
Transplant Updates
Heart Transplantation A Half Century of Progress April 6, 2019 David D’Alessandro, M.D. Surgical Director, Cardiac Transplantation and Mechanical Circulatory Support Disclosures • None 2 Heart Transplantation • How did we get there? • How far have we come? • Where are we going? The danger of touching the heart "Surgery of the heart has probably reached the limits set by Nature to all surgery. No method, no new discovery, can overcome the natural difficulties that attend a wound of the heart." Stephen Paget, 1896 Alexis Carrel • published his technique for the vascular anastomosis in 1902 • 1905 reported heterotopic kidney and heart transplantation in dogs • Nobel Prize in Physiology 1912 History of Cardiac History Evolution of CPB Early Challenges in Cardiac Surgery 1920s - 1950s • Multiple failed attempts at operative treatment of rheumatic mitral stenosis • Poor visualization during ASD repairs Tubbs dilator Heart Lung Machine John Gibbon 1953 Cecilia Brevolek: May 6th as the first successful truly open-heart operation performed with the use of a heart-lung machine. Norman Shumway Surg Forum 1960;11:18. James Hardy • First human cardiac transplant was a chimpanzee xenograft performed at the University of Mississippi in 1964. Operative Permit Public ridicule “…not only immoral, but amoral”. Richard Lower • 1966 Lower performed “a reverse Hardy” • Passed up an opportunity to perform a human to human transplant in 1966 due to over cautious concern about secondary incompatibility Christiaan Barnard Louis Washkansky (December 3, 1967) “My moment of truth – the moment when the enormity of it all really hit me – was just after I had taken out Washkansky’s heart.