Guangmei Yan M.D., Ph. D

Sun Yat-sen University (SYSU) Address 1: 74, Zhongshan Road 2, Guangzhou 510089 Address 2 : 135 Xingangxi Road, Guangzhou, China 510275 86-20-87333258, 87580159, 84113817 (office) [email protected] Education 1985.9-1989.5: Ph.D. Depart. of Pharmacology, Zhongshan Medical College of SYSU 1982.2-1985.1: Master Depart. of Pharmacology, Zhongshan Medical College of SYSU 1980.9-1982.1: Instructor National High-class Pharmacological Teacher Training Program, Hunan Medical University 1976.9-1980.1: M.D. Department of Clinical Medicine, Hunan Medical University Experiences: 1996.2-present: • Vice President of Sun Yat-sen University, • Standing Director of the Chinese Pharmacological Society; • Member of Director Board of Chinese High-class Medicine Education Society; • Vice President of the Pharmacological Society of Guangdong Province • Vice President of the Neuronal Science Society of Guangdong Province； • Vice President of the Young Scientist Association of Guangdong Province • Member of the Political Consulting Committee of Guangdong Province 1995．12-present Professor and Ph.D. Tutor, Department of Pharmacology, Zhongshan Medical College of SYSU. 1994.5-1996.2: Visiting Scholar Institute of Central Neuronal System, Eli Lilly Company, USA Department of Pharmacology and Toxicology, Indiana University, USA 1991.6—1994.4: Postdoctoral Fellow National Institute of Mental Health, National Institute of Health (NIMH/NIH), USA 1989.12-1991.5 Associate Professor Department of Pharmacology, Zhongshan Medical College of SYSU. 1987.12-1988.12 Lecturer Department of Pharmacology, Zhongshan Medical College of SYSU. 1985.2-1985.8: Assistant Lecturer Department of Pharmacology, Zhongshan Medical College of SYSU 1980.1-1982.1: Assistant Lecturer Department of Medicine, Jishou University, Hunan Province

Awards and honors: 1. Second scientific prize Award: Government of Guangdong Province, May.1998 1

2. Third scientific prize Award: Minister of health of China, Sep,1998 3. Competitive NIH Fogarty International Fellowship Award: F05TW04591, 1991-1993 4. Outstanding Youth Scientist Award: The National State Council of People's Republic of China. Nov. 1991 5. Third scientific prize Award: Chinese Academy of Sciences, Dec.1988. 6. Second scientific prize Award: Chinese Education Committee, Dec.1987 7. Second scientific prize Award: Government of Guangdong Province, Nov.1985

Publications: 1. Yuan Lin#, Haipeng Zhang#, Jiankai Liang#, Kai Li, Wenbo Zhu, Liwu Fu, Fang Wang, Xiaoke Zheng, Huijuan Shi, Sihan Wu, Xiao Xiao, Lijun Chen, Lipeng Tang, Min Yan, Xiaoxiao Yang, Yaqian Tan, Pengxin Qiu, Yijun Huang, Wei Yin, Xinwen Su, Haiyan Hu, Jun Hu*, and Guangmei Yan*.Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. PNAS, 2014,111 (42):4504-4512. 2. Haiyan Hu, Yuehan Zhou, Tiandong Leng, Ailing Liu, Youqiong Wang, Xiuhua You, Jingkao Chen, Lipeng Tang, Wenli Chen, Pengxin Qiu, Wei Yin, Yijun Huang, Jingxia Zhang, Liwei Wang, Hanfei Sang* and Guangmei Yan*. A major cholesterol metabol i te cholestane-3β, 5α, 6β-triolfunctions as an endogenous ne uroprotectant. The Journal of Neuroscience, August 20, 2014, 34(34): 11426 –11438. 3. Sijia Zheng,*Yanqi Xie,*Yuan li, Ling li, Ning Tian, Wenbo Zhu, Guangmei Yan, Chuanbin Wu, Haiyan Hu*. Development of high drug loading nanomicelles targeting steroids to the brain. 2014, 9: 55-66. 4. Yanqiu Ou, Xiaoke Zheng, Yixing Gao, Minfeng Shu, Tiandong Leng, Yan Li, Wei Yin, Wenbo Zhu, Yijun Huang, Yuxi Zhou, Jianjun Tang, Pengxin Qiu, Guangmei Yan, Jun Hu*, Huaizhen Ruan*, Haiyan Hu*. Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics. Urologic Oncology: Seminars and Original Investigations. 2014, 32(1): 47.e21–47.e28. 5. Huawei Sun; Xiaoke Zheng; Yuehan Zhou; Wenbo Zhu; Xiuren Gao; Tiandong Leng*; Yanqiu Ou; Pengxin Qiu; Minfeng Shu; Guangmei Yan. Alphaxalone inhibits growth, migration and invasion of rat C6 malignant glioma cells. Steroids 78(10):1041-5. 2013. 6. Jiesi Chen, Tiandong Leng,, Wenli Chen, Min Yan, Wei Yin, Yijun Huang, Suizhen Lin, Dayue Duan, Jun Lin, Gongxiong Wu, Jingxia Zhang*, Guangmei Yan*. A synthetic steroid 5α-androst-3β,5,6β-triol blocks hpoxia/reoxygenation-induced neuronal injuries via protection of mitochondrial function. Steroid, 2013, 78:996-1002. 7. Xiaoxiao Yang, Shifeng Li, Wande Li, Jingkao Chen, Xiao Xiao, Youqiong Wang, Guangmei Yan* and Lijun Chen*. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncology Reports. 2013, 29: 541-548. 8. Zhihui Mai., Zhuli Peng., Sihan Wu., Jinglan Zhang, Lin Chen, Huangyou Liang, Ding Bai,

Guangmei Yan, Hong Ai*. Single Bout Short Duration Fluid Shear Stress Induces Osteogenic Differentiation of MC3T3-E1 Cells via Integrin b1 and BMP2 Signaling Cross-Talk. Plos One, 2013, 8 (4): 1-10. 9. Yunlin Dou, Yuan Li, Jingkao Chen, Sihan Wu, Xiao Xiao, Shanshan Xie, Lipeng Tang, Min Yan, Youqiong Wang, Jun Lin*, Wenbo Zhu* and Guangmei Yan. Inhibition of cancer cell proliferation by midazolam by targeting transient receptor potential melastatin 7. Oncology Letters, 2013, 5: 1010-1016. 10. Sihan Wu, Yuan Lin, Dong Xu, Jiesi Chen, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Xingwen Su, Yuxi Zhou, Pengxin Qiu and Guangmei Yan*. MiR-135a Functions as a Selective Killer of Malignant Glioma. Oncogene, 2012, 31: 3866-3874. 11. Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Haipeng Zhang, Sihan Wu, Jingkao Chen, and Guangmei Yan*. MiR-335 is required for differentiation of malignant glioma cells induced by activation of cAMP/PKA pathway. Molecular Pharmacology, 2012, 81: 292-298. 12. Wenbo Zhu, Jingjie Li, Sihan Wu, Shifeng Li, Liang Le, Xingwen Su, Pengxin Qiu, Haiyan Hu, Guangmei Yan*. Triptolide cooperates with cisplatin to induce apoptosis in gemcitabine- resistant pancreatic cancer. Pancreas, 2012, 41 (7): 1029-1038. 13. Haipeng Zhang, Wenbo Zhu, Xingwen Su, Sihan Wu, Yuan Lin, Jingjie Li, Youqiong Wang, Jingkao Chen, Yuxi Zhou, Pengxin Qiu, Guangmei Yan, Shujin Zhao, Jun Hu and Jingxia Zhang. Triptolide inhibits proliferation and invasion of malignant glioma cells. Journal of Neuro-oncology. 2012, 109:53-62. 14. Jingjie Li, Wenbo Zhu, Tiandong Leng, Minfeng Shu, Yijun Huang, Dong Xu, Pengxin Qiu, Xingwen Su and Guangmei Yan*. Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells. Oncology Reports. 2011, 25: 979-987. 15. Minfeng Shu, Yuxi Zhou, Wenbo Zhu, Sihan Wu, Xiaoke Zheng, Guangmei Yan*. Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells. Molecular Oncology, 2011, 219: 1-8. 16. Songmin He, Wenbo Zhu, Yuxi Zhou, Yijun Huang, Yanqiu Ou, Yan Li, Guangmei Yan*. Transcriptional and post-transcriptional downregulation of cyclin D1 contributes to C6 glioma cell differentiation induced by Forskolin. Journal of Cellular Biochemistry, 2011, 112:2241-2249. 17. Minfeng Shu, Xiaoke Zheng, Sihan Wu, Huimin Lu, Tiandong Leng, Wenbo Zhu, Yuehan Zhou, Yanqiu Ou, Xi Lin, Yuan Lin, Dong Xu, Yuxi Zhou, Guangmei Yan*. Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells. Molecular cancer, 2011, 10 (1): 59. 18. Guangmei Yan*, Guojie Zhang, Xiaodong Fang, Yanfeng Zhang, Cai Li, Fei Ling, David N Cooper, Qiye Li, Yan Li, Alain J van Gool, Hongli Du, Jiesi Chen, Ronghua Chen, Pei Zhang, Zhiyong Huang, John R Thompson, Yuhuan Meng, Yinqi Bai, Jufang Wang, Min Zhuo, Tao Wang, Ying Huang, Liqiong Wei, Jianwen Li, Zhiwen Wang, Haofu Hu, Pengcheng Yang, Liang Le, Peter D Stenson, Bo Li, Xiaoming Liu, Edward V Ball, Na An, Quanfei Huang, Yong Zhang, Wei Fan, Xiuqing Zhang, Yingrui Li, Wen Wang, Michael G Katze, Bing Su, Rasmus

Nielsen, Huanming Yang, Jun Wang, Xiaoning Wang & Jian Wang. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 2011, 29: 1019-1025. 19. Huanhuan Sun, Haiqing Ma, Guangyao He, Jiashu Chen, Pengxin Qiu and Guangmei Yan*. Effects of temperature, pH, and inhibitors on the procoagulant characterization of FIa, a factor X activator from the venom of Daboia russellii siamensis (Myanmar). Arch Pharm Res, 2010, 33(7): 1043-1048. 20. Sen Luo, Rongrong Wang, Weijian Jiang, Xi Lin, Pengxin Qiu, Guangmei Yan*. A novel recombinant snake venom metalloproteinase from Agkistrodon acutus protects against taurocholate-induced severe acute pancreatitis in rats. Biochimie, 2010, 92: 1354-1361. 21. Yan Li, Huimin Lu, Yijun Huang, Ru Xiao, Xiaofeng Cai, Songmin He and Guangmei Yan*. Glycogen synthase kinases-3b controls differentiation of malignant glioma cells. International Journal of Cancer, 2010, 127: 1271–1282. 22. Yan Li, Hui-min Lu, Gang Li, Guang-mei Yan*. Glycogen synthase kinase-3β regulates astrocytic differentiation of U87-MG human glioblastoma cells. Acta Pharmacologica Sinica, 2010, 31:355-360. 23. Yan-qiu Ou, Wen bo Zhu, Yan Li, Peng-xin Qiu, Yi-jun Huang, Jun Xie, Song-min He, Xiao-ke Zheng, Tian-dong Leng, Dong Xu, Guang-mei Yan*. Aspirin inhibits proliferation of gemcitabine- resistant human pancreatic cancer cells and augmentsgemcitabine-induced cytotoxicity. Acta Pharmacologica Sinica, 2010, 31: 73–80. 24. Li-jun Chen, Wan-de Li, Shi-feng Li, Xing-wen Su, Guang-yun Lin, Yi-jun Huang, Guang-mei Yan*. Bleomycin induces upregulation of lysyl oxidase in cultured human fetal lung fibroblasts. Acta Pharmacologica Sinica, 2010, 31: 554–559. 25. Tiandong Leng, Jingxia Zhang, Jun Xie, Shujia Zhou, Yijun Huang, Yuehan Zhou, Wenbo Zhu, Guangmei Yan*. Synthesis and anti-glioma activity of 25(R)- spirostan-3, 5-,6-,19-tetrol. Steroids, 2010, 75: 224–229. 26. Wenbo Zhu, Songmin He , Yan Li , Pengxin Qiu, Minfeng Shu, Yanqiu Ou, Yuehan Zhou, Tiandong Leng, Jun Xie, Xiaoke Zheng, Dong Xu, Xingwen Su, Guangmei Yan*. Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells. Vascular Pharmacology, 2010, 52: 46–54. 27. Weiqing Chen, Wenhua Ling, Ciyong Lu, Yuantao Hao, Zhongning Lin, Li Ling, Jian Huang, Gang Li and Guangmei Yan*. Which preventive measures might protect health care workers from SARS? BMC Public Health, 2009, 9:81. 28. Jun Xie,Yan Li,Yijun Huang,Pengxin Qiu,Minfeng Shu,Wenbo Zhu,Yanqiu Ou, Guangmei Yan*. Anesthetic Pentobarbital inhibits proliferation and migration of malignant glioma cells. Cancer letters, 2009, 282: 35-42. 29. Wenbo Zhu, Yanqiu Ou, Yan Li,Ru Xiao, Minfeng Shu,Yuehan Zhou, Jun Xie, Songmin He, Pengxin Qiu, and Guangmei Yan*. A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma cells via

Down-Regulation of the Nuclear Factor-κB Pathway. Molecular Pharmacology, 2009, 75:1-8. 30. Weijian Jiang, Tao Ma, Xingwen Su, Pengxin Qiu, Guangmei Yan*. Enzymatic activities and functional characterization of a novel recombinant snake venom proteinase from Agkistrodon Acutus. Biochimie, 2009, 91: 277-287. 31. Zhaohui Pei, Zhiqiang Zhuang, Pingxi Xiao, Jingzao Chen, Hanfei Sang, Jun Ren, Zhenbiao Wu, Guangmei Yan*. Influence of Infrasound Exposure on the Whole L-type Calcium Currents in Rat Ventricular Myocytes. Cardiovasc Toxicol. 2009, 9 (2): 70-77. 32. Dong Xu, Yi-jun Huang, Yan Li, Wei Yin, Guangmei Yan*. Orphan nuclear receptor Nur77 is required for the differentiation of C6 glioma cells induced by cholera toxin. Acta Pharmacologica sinica, 2009, 30:1543-1549. 33. Jun Hu, Xiaofeng Cai, and Guangmei Yan*. Alphavirus M1 induces apoptosis of malignant glioma cells via downregulation and nucleolar translocation of P21WAFI/CIPI Protein. Cell cycle. 2009, 8 (20): 1-11. 34. Ailing Liu, Xinwei Wang, Aihua liu, Xingwen Su, Weijian Jiang, Pengxin Qiu, Guangmei Yan*. JNK and P38 were involved in hypoxia and reoxygenation –induced apoptosis of cultured rat cerebellar granule neurons. Experimental and Toxicologic Pathology , 2009, 61:137-143. 35. Rongrong Wang, Jinlian Cai, Yijun Huang, Dong Xu, Hanfei Sang, Guangmei Yan*. Novel recombinant fibrinogenase of Agkistrodon acutus venom protects against LPS-induced DIC. Thrombosis Research, 2009, 123: 919-924. 36. Huimin Lu, Yan Li , Minfeng Shu , Jianjun Tang , Yijun Huang , Yuxi Zhou , Yingjie Liang and Guangmei Yan*. Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas. FEBS Journal, 2009, 276: 7291- 7304. 37. Wenbo Zhu, Haiyan Hu, Pengxin Qiu, Guangmei Yan*. Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-κB-related mechanism . Oncology Reports, 2009, 22(6): 1397-1401. 38. Weijian Jiang, Tao Ma, Xingwen Su, Pengxin Qiu, Guangmei Yan*. Enzymatic activities and functional characterization of a novel recombinant snake venom proteinase from Agkistrodon Acutus. Biochimie, 2009, 91 (2): 277-287. 39. Rongrong Wang, Pengxin Qiu, Weijian Jiang, Xiaofeng Cai, Yanqiu Ou,Xingwen Su, Jinlian Cai, Jiashu Chen, Wei Yin, Guangmei Yan*. Recombinant fibrinogenase from Agkistrodon acutus venom protects against sepsis via direct degradation of fibrin and TNF-alpha. Biochem Pharmacol, 2008, 76(5): 620-630. 40. Yan Li, Wei Yin, Xia Wang, Wenbo Zhu, Yijun Huang, and Guangmei Yan*. Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. PNAS, 2007, 104(33): 13438–13443. 41. Lin Cao, Dexiong Cao, Xingwen Su, Lijun Chen, Ailin Liu, Weijian Jiang, Yuping Wu, Pengxin Qiu, Guangmei Yan*. Activation of PI3-K/Akt pathway for thermal

5 preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis. Acta Pharmacol Sin, 2007, 28 (2): 173–179. 42. Qinghua Liu, Xiaowei Zhang, Wei Yin, Chenji L, Yijun Huang, Pengxin Qiu, Xingwen Su, Songnian He, Guangmei Yan*. A catalog for transcripts in the venom gland of the Agkistrodon acutus: identification of the toxins potentially involved in coagulopathy. Biochem Biophys Res Commun, 2006, 341(2):522-531. 43. Bing Zhang, Qinghua Liu, Wei Yin, Xiaowei Zhang, Yijun Huang,Yingfeng Luo, Pengxin Qiu, Xingwen Su, Jun Yu, Songnian Hu1,2 and Guangmei Yan*. Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags. BMC Genomics, 2006, 7:152. 44. Lipeng Xu, Weijian Jiang, Tao Ma, Pengxin Qiu, Jing Hou, Yijun Huang, Jiashu Chen, Guangmei Yan*. Expression, purification and molecular modeling of recombinant fibrinogenase [IV], a metalloproteinase from Deinakistrodon acutus venom. Toxicon, 2006, 47(2): 241-248. 45. Zhiyong Lou, Jing Hou, Xiuxia Liang, Jiashu Chen, Pengxin Qiu, Yiwei Liu, Ming Li, Zihe Rao, Guangmei Yan*. Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus. J Struct Biol, 2005, 152(3): 195-203. 46. Lipeng Xu, Tao Ma, Weijian Jiang, Pengxin Qiu, Xia Wang, Xingwen Su, Guangmei Yan*. Recombinant production of fibrinogenase IV from Agkistrodon acutus venom and its preliminary evaluation. Appl Microbiol Biotechnol, 2006, 21:1-5. 47. Weiqing Chen, Ciyong Lu, Tzewai Wong, Wenhua Ling, Zhongning Lin, Yuantao Hao, Qing Liu, Jiqian Fang, Yun He, Futian Luo, Jin Jing, Li Ling, Xiang Ma, Yimin Liu, Guihua Chen, Jian Huang, Yuansen Jiang, Wenqi Jiang, Hequn Zou, and Guangmei Yan*. Anti-SARS-CoV immunoglobulin G in healthcare workers, Guangzhou, China. Emerg Infect Dis, 2005, 11(1): 89-94. 48. Yiwen Wang, Xiuxia Liang, Jiashu Chen, Qi Chen, Pengxin Qiu, Xi Lin and Guangmei Yan*. Fibrin(ogen)olytic character of FIIa isolated from Agkistrodon acutus venom. Acta Pharmacol Sin, 2005, 26(6): 691-695. 49. Xiuxia Liang, Yingna Zhou, Jiashu Chen, Pengxin Qiu, Huizhen Chen, Huanhuan Sun, Yuping Wu, Guangmei Yan*. Enzymological characterization of FII(a), a fibrinolytic enzyme from Agkistrodon acutus venom. Acta Pharmacol Sin, 2005, 26(12):1474-1478. 50. Jing Hou, Ming Li, Jiashu Chen, Pengxin Qiu, Xiuxia Liang, Zhiyong Lou, Zihe Rao, Guangmei Yan*. Crystallization and preliminary X-ray studies of a non-haemorrhagic fibrin (ogen) olytic metalloproteinase from the venom of Agkistrodon acutus. Acta Crystallograph Sect F Struct Biol Cryst Commun, 2005, 61(Pt 4): 355-358. 51. Rongbiao Pi, Wei Yin, Suqiu Zheng, Pengxin Qiu, Jian Zhou, Wei Guo, Tao Su, Guangmei Yan*. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat. Brain Res Mol Brain Res. 2004, 127(1-2):136-139.

52. Qingqing Wang, Jiashu Chen, Xiuxia Liang, Pengxin Qiu, Yiwen Wang, Guangmei Yan*. Hemorrhagic activity and mechanism of FIIa, a fibrinolytic enzyme from Agkistrodon acutus venom. Acta Pharmacol Sin, 2004, 25(4): 514-521 53. Lijun Chen, Xingwen Su, Pengxin Qiu, Yijun Huang, Guangmei Yan*. Thermal preconditioning protected cerebellar granule neurons of rats by modulating HSP70 expression. Acta Pharmacol Sin, 2004, 25(4): 458-461 54. Ling-zhi Zhao, Xingwen Su, Pengxin Qiu, Yijun Huang, Haixin Zhang, Rongbiao Pi, Guangmei Yan*. Suppression of PHospho-p44/p42 and Induction of C-jun were involved in Diphenylhydantoin-mediated toxicity of cultured Rat cerebrellar Granule Neurons. Acta Pharmacol Sin, 2003, 23(4): 342-381. 55. Xiuxia Liang, Jiashu Chen, Yingna Zhou, Pengxin Qiu, Guangmei.Yan*. Purification and biocharacterization of FIIa, afibrinolytic enzyme from Agkistrodon acutus venom. Toxicon, 2001, 39: 1133-1139. 56. Jiashu Chen, Xiuxia Liang, Pengxin Qiu, Guangmei Yan*, Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model. Acta Pharmacologica Sinica, 2001, 22(5):420-422. 57. Rongbiao Pi, Mingtao Li, Pengxing Qiu, Xingwen Su, Suizhen Lin, Guangmei Yan*. cAMP- and Ca2+-independently protective effect of 3-Isobuty-L- methylxanthine against apoptosis on cultured cerebellar granule neurons. Chin Pharm J, 2001, 36(4): 240-244. 58. Shuqiu Zheng, Tong Li, Yixiong Xuan, Suizhen Lin, Lijuen Chen, Guangmei Yan*. Neuroprotective effect of alpha-dihydroergocrypine depends on activation of nuclear factor kappa B. Acta Pharmaceutica Sinica, 2000, 35:898-901. 59. Rongbiao Pi, Pengxin Qiu, Xingwen Su, Xiang Wan, Suizhen Lin, Mingtao Li, and Guangmei Yan*. Protective effect of lithium on cultured cerebellar granule neurons against apoptosis induced by LY 294002, a specific Inhibitor of phosphatidylinositol 3-kinase in vitro. Chin J Pharmacol &Toxicol, 2000, 14:196-201. 60. Wenya Wang, Mingtao Li, Rongbiao Pi, Pengxin Qiu, Xingwen Su, Suizhen Lin, and Guangmei Yan*. Antagonistic action of caffeine against LY294002-induced apoptosis in cerebellar granule neurons. Acta Pharmacol Sin, 2000, 21: 35-40. 61. Ming-tao Li, Wenya Wang, Suizhen Lin, Guangmei Yan. Protective action of the specific p38 MAPK inhibitor SB203580 in cerebellar granule neurons of rat pups. Acta Pharmacol Sin, 2000, 35: 496-499. 62. Wenya Wang, Mingtao Li, Pengxin Qiu, Xingwen Su, Suizhen Lin, Guangmei Yan*. Relationship between survival effect of caffeine and levels of intercellular calcium in cerebellar granule neurons. Chin J Pharmacol &Toxicol, 2000, 14:101-107. 63. Xiaoyu Li, Ying Ouyang, Suizhen Lin, Xiang Wan, Guangmei Yan and Pengxin Qiu. Research on the effects of cerebrolysin on primary cultured rat cerebellar granular neurons. Chin J Practl Pediatr, 2000, 15: 464-466. 64. Xiaoyu Li, Suizhen Lin, Xiaolin Xu, Rongbiao Pi and Guangmei Yan*. Activation of Gs-protein affects apoptosis of rat cerebellar granule neurons induced by bilirubin. Chin J 7

Pediatr, 2000, 38(1): 16-19. 65. Xiaoyu Li, Ying Ouyang, Suizhen Lin, Xiang Wan, Guangmei Yan and Pengxin Qiu. Cerebrolysin induced death of cerebellar granular neurons of rat in primary culture. Natl Med J China, 2000, 80(2): 104-105. 66. Pengxin Qiu, Mingtao Li, Xiaoli Tang, Xingwen Su, Suizhen Lin, Guangmei Yan*. Protective effects of polysaccharide from holothuria atra on apoptosis of cortical neurons induced by amyloid β-protein Chinese Traditional and Herbal Drugs. 2000, 31:271-274. 67. Xiaoyu Li, Suizhen Lin, Xiaolin Xu, Rongbiao Pi, Guangmei Yan*. Primary studies on mechanism of bilirubin-induced apoptosis of rat cerebellar granule neurons. Acadc Periodical Abstr of China. 1999, 5(5): 659-662. 68. Suizhen Lin, Xiaoyu Li and Guangmei Yan*. Intracellular Ca2+, Na+ and ATP homeostasis mediated NMDA-induced excitoprotection in rat cerebellar granule neurons. Acad J SUMS. 1999, 20(4): 252-256. 69. Xiaoli Tang, Pengxin Oiu, Mingtao Li, Xingwen Su, Suizhen Lin, Guangmei Yan*. Polysaccharide sulphate blocks apoptosis induced by mastoparan in cortical neurons. Chin Pharmacol Bull. 1999, 15(5): 407-410. 70. Xingwen Su, Rongbiao Pi, Suizhen Lin, Pengxin Oiu, Xiaoli Tang, Xiang Wan, Mingtao Li, Guangmei Yan*. Protection of caffeine against neuronal apoptosis induced by glutamate. Chin Pharmacol Bull. 1999, 15(6): 509-512. 71. Suizhen Lin, Xiaoyu Li, Guangmei Yan*. Bilirubin induced apoptosis of cerebellar granule neurons. Natl. Med. J China. 1999, 79:125-128. 72. Suizhen Lin, Xiaoyu Li, Liang Tao and Guangmei.Yan*. Mechanism of mastoparan–induced neuronal death in cultured cerebellar granule neurons. Chin Pharmacol Bull, 1998, 14(4): 332-336. 73. Suizhen Lin, Mingtao Li, Xiaoyu Li and Guangmei Yan*. Neurotoxicity induced by berberine in cultured cortical and cerebellar granule neurons of rat. Acad J SUMS, 1998, 19(4): 250-254. 74. Kelly R. Bales. Yansheng Du. Richard C. Doel. Guangmei Yan*. Elizabeth Hamilton-Byrd. and Steven M. Paul. The NF-kB/Rel family of proteins mediates Aβ-induced neurotoxic and glial activation. Mol. Brain Res. 1998, 718:38-43. 75. Mingtao Li, Xingwen Su, Juan Sun, Pengxin,Qiu, Yuping Wu, Guangmei Yan*. Protection of Bcl-2 protein against cyclopiazonic acid-induced apoptosis in Chinese hamster ovary cells Chinese J. Pharmacol. Toxicol. 1998, 12(3):184-187. 76. Mingtao Li, Juan Sun, Pengxin Qiu and Guangmei Yan*. Mitochondrial mechanisms of Bcl-2 on ionizing radiation-induced apoptosis. Acta Biochimica et Biophysica Sinica. 1997, 22(5):495-502, 77. Suizhen Lin. Guangmei Yan*. Kimberly E. Koch and Steven M. Paul. Robert Irwin. Mastoparan- induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores. Brain Res. 1997, 771:184-195.

78. Guangmei Yan, Suizhen Lin, Robert P. Irwin and Steven M. Paul. Activation of G- proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. J.Neurochem. 1995, 65:2425-2431. 79. Guangmei Yan, Robert P. Irwin, Suizhen Lin, Michael Weller, Katherine A. Wood and Steven M. Paul. Diphenylhydantoin induces apoptotic cell death of cultured rat cerebellar granule neurons. J. Pharmacol. Exp. Ther.1995, 274:983-990. 80. G.uangmei Yan, Suizhen Lin, Robert P. Irwin and Steven M. Paul. Activation of muscarinic cholinergic receptors block apoptosis of cultured cerebellar granule neurons. Molecular Pharmacology. 1995, 47:248-257. 81. Pengxin Qiu, Minghua Zhou, Weiquan Huang,Yan Guangmei and Benrong Hu. Distribution of benzodiazepine receptor in rat brain Chinese Sci. Bull. 1995, 40(22):1913-1916. 82. Binhui Ni, Xin Wu, Guangmei Yan, Jie Wang and Steven Paul. Regional expression and cellular localization of the Na+-dependent inorganic phosphate cotransporter of rat brain. J. Neurosci. 1995,15:5789-5799. 83. Pengxin Qiu，Guangmei Yan，Benrong Hu，Xinwen Shu and Lehe Liu. Purification of benzodiazepine receptor protein from cortex of pig brain with a new affinity column. Acad J SUMS. 1995,16：42-44. 84. Guangmei Yan, Suizhen Lin, Kelly Bales, Jun Gu, Robert P. Irwin and Steven M.. Paul.Bilirubin induces Apoptosis of Cerebellar Granule Neurons via Activation of NF-kB. Abstr. Soc. Neurosci. 21:1738, 1995 85. Guangmei Yan, Binhui Ni, Michael Weller, Katherine A. Wood and Steven M. Paul. Depolarization or glutamate receptor activation blocks apoptotic cell death in cultured cerebellar granule neurons. Brain Res. 1994, 656:43-51. 86. Guangmei Yan. Purification and characterization of benzodiazepine receptor protein from cortex of pig brain with a new affinity column. Progress Physiol. Scie. 1990, 25 (4):187-193. 87. Guangmei Yan. The study of benzodiazepine receptors in centre nervous system Progress Physiol. Scie. 1990, 21(3):256-259. 88. Guangmei Yan and Benrong Hu. Kinetics and photoaffinity labeling of benzodiazepine receptor in frontal cortex of rabbit brain. Chinese J. Pharmacol. Toxicol. 1987, 1(2):81-85. 89. Guangmei Yan and Benrong Hu. Benzodiazepine derivatives: relationship between anticonvulsant activity and affinity to rabbit frontal receptors Acta Pharmacologica Sinica. 1986, 7: 389-393. 90. Guangmei Yan and Benrong Hu. The regional and subcellular distribution of benzodiazepine receptor and regulation by GABA agonists or antagonists in CNS of rabbit. Acta Acd. Med. Zhongshan. 1985, 6: 1-5.

Book Published:

1. Guang-Mei Yan and Steven M. Paul. Cultured cerebellar granule neurons as a model of neuronal apoptosis. In Apoptosis Techniques and Protocols. (Ed: Judes Poirier) Human Press, Inc., Totowa NJ 07512, USA. 49-66 2. Guang-Mei Yan. Pharmacology. Higher Education Press of China, 2004. 2. Guang-Mei Yan. Pharmacology. Higher Education Press of China, 2009. Grants Awarded for Scientific Research： 1. National nature science foundation of china was granted in 1986 2. The youth national nature science foundation of china was granted in 1988 3. Huo Ying-dong science foundation was granted in 1990 4. National outstanding youth scientist foundation of China was granted in 1996 5. Nature science foundation of Guangdong province was granted in 1996. 6. Education foundation of Guangdong province was granted in 1997 7. National nature science foundation of china (Major project) was granted in 1997 8. Minister of health and education scientific foundation of china for retuning scholar was granted in 1997. 9. CMB/SUMS Returning Scholar was granted in 1998 10. National Natural Science Fund of China in 2004 11. Team research project of Natural Science Fund of Guangdong province in 2004. 12. Doctorate subject fund of Chinese Education Department in2004 13. Science and Technology Project of Guangdong province in 2004 14. National 863 key project 2006 15. Key program, National Natural Science Foundation of China in 2007 (No. 30830111), 16. Guangzhou Program Project of science and technology in 2008 (No. 2008Z1-E561) 17. National key projects of science and technology in 2009 (No. 2009ZX09102-013) 18. National key projects of science and technology (No. 2009ZX09102-217) 19. National Nature Science Foundation of china in 2013(No. 81373428) 20. National Major Scientific and Technological Special Project in 2015 (No. 2015ZX09J15106-001)