An International Classification of Inherited Metabolic Disorders (ICIMD)

Carlos R. Ferreira1*, Shamima Rahman2,3, Johannes Zschocke4*, ICIMD advisory group

1National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA

2Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

3 Metabolic Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom

4Institute of Human Genetics, Medical University Innsbruck, Innsbruck, Austria

*Addresses for Correspondence:

Carlos R. Ferreira, M.D. Medical Genomics and Metabolic Genetics Branch National Human Genome Research Institute National Institutes of Health 49 Convent Dr Building 49, Room 4A38 Bethesda, MD 20814 USA [email protected]

Univ.-Prof. Dr. med. Johannes Zschocke, Ph.D. Institute of Human Genetics Medical University Innsbruck Peter-Mayr-Str. 1 6020 Innsbruck Austria [email protected]

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The ICIMD advisory group

Abdenur Jose [email protected] Division of Metabolic Disorders, CHOC Children's Hospital, Orange, California, USA Ali Houda [email protected] Inserm, US14-Orphanet, Paris, France Artuch Rafael [email protected] Hospital Sant Joan de Déu, Esplugues de llobregat, Barcelona, Spain Ballabio Andrea [email protected] Telethon Institute of Genetics and Medicine (TIGEM) and Medical Genetics Unit, Department of Translational Medicine, Federico II University, Naples, Italy; Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA Barshop Bruce [email protected] Dept of Pediatrics, University of California San Diego, La Jolla, California, USA Baumgartner Matthias [email protected] Division of Metabolism, University Children's Hospital Zürich, Switzerland Bertini Enrico Silvio [email protected] Dept. of Neurosciences, Bambino Gesù, Children's Research Hospital, Rome, Italy Blau Nenad [email protected] Division of Metabolism, University Children's Hospital Zürich, Switzerland Carelli Valerio [email protected] IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy; 2. Unit of Neurology, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy Carroll Christopher [email protected] Genetics Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK Chinnery Patrick F. [email protected] Department of Clinical Neurosciences, School of Clinical Medicine & Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK Christodoulou John [email protected] Murdoch Children's Research Institute, Melbourne, Victoria, Australia Cornejo Veronica [email protected] Genetics & Metabolic Disease Laboratory, Nutrition & Food Technology Institute (INTA), University of Chile, Santiago, Chile Darin Niklas [email protected] Dept of Pediatrics, University of Gothenburg, Sweden Derks Terry [email protected] Beatrix Children's Hospital, Division of Metabolic Diseases, University of Groningen, University Medical Center Groningen, The Netherlands Diodato Daria [email protected] Dept. of Neurosciences, Bambino Gesù Children's Research Hospital, Rome, Italy

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Dionisi-Vici Carlo [email protected] Bambino Gesù Children's Hospital, Rome, Italy Duley John A. [email protected] University of Queensland, St Lucia, Australia Fukao † Toshi [email protected] Dept of Pediatrics, Yanagido, Gifu, Japan García- Ángeles [email protected] Hospital Sant Joan de Déu, Esplugues de Cazorla llobregat, Barcelona, Spain Giugliani Roberto [email protected] Medical Genetics Service, Hospital de Clinicas de Porto Alegre, Brazil Goldstein Amy [email protected] Dept of Pediatrics, Div of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Hoffmann Georg [email protected] University Children's Hospital heidelberg.de Heidelberg, Germany Horvath Rita [email protected] Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK Ibarra Isabel [email protected] Instituto de Investigaciones Biomédicas UNAM – Instituto Nacional de Pediatría SS CDMX México, Mexico Inwood Anita [email protected] Dept of Metabolic Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia Jaeken Jaak [email protected] Centre of Metabolic Disease, University Hospital Leuven, Belgium Jimenez- Cecilia [email protected] Hospital Sant Joan de Déu, Esplugues de Mallebrera llobregat, Barcelona, Spain Karaa Amel [email protected] Genetics Unit, Mass General Brigham Hospital. Harvard Medical School, Boston, Massachusetts, USA Keller Markus [email protected] Institute of Human Genetics, Medical University Innsbruck, Austria Klopstock Thomas [email protected] Department of Neurology, Friedrich- muenchen.de Baur-Institute, University Hospital, LMU Munich; German Center for Neurodegenerative Diseases (DZNE); and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany Kölker Stefan [email protected] University Children's Hospital heidelberg.de Heidelberg, Germany Kornblum Cornelia [email protected] Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn, Bonn, Germany Kožich Viktor [email protected] Dept of Pediatrics & Inherited Metabolic Disorders, Charles University-First Faculty of Medicine and General University Hospital, Prague, Czech Republic Lamperti Costanza [email protected] Division of Medical Genetics and Neurogenetic, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy Larsson Nils-Göran [email protected] Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm, Sweden

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Lemes Aida [email protected] Instituto de la Seguridad Social-BPS, Montevideo, Uruguay Lewis Barry [email protected] Dept of Clinical Biochemistry, PathWest, Nedlands, Perth, Australia Mancuso Michelangelo [email protected] Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Italy McFarland Robert [email protected] Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK Mochel Fanny [email protected] Reference Center for Adult Neurometabolic diseases, Sorbonne Université, La Pitié-Salpêtrière Hospital, Paris, France Montoya Julio [email protected] Departamento de Bioquímica, Biología Molecular y Celular; Universidad de Zaragoza. Instituto de Investigación Sanitaria (IIS) de Aragón. Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER). 50013- Zaragoza, Spain Morava Eva [email protected] Dept of Clinical Genomics, Mayo Clinic, Rochester, Minnesota, USA Naess Karin [email protected] Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden Okuyama Torayuki [email protected] National Center for Child Health and Development, Okura, Setagaya-ku, Japan Olry Annie [email protected] Inserm, US14-Orphanet, Paris, France Paquis- Veronique [email protected] Reference Centre for Mitochondrial Flucklinger Diseases, Dept of Medical Genetics, University of Nice Côte d'Azur, Nice, France Parikh Sumit [email protected] Center for Pediatric Neurosciences, Cleveland Clinic Main Campus, Cleveland, Ohio, USA Patterson Marc [email protected] Division of Child & Adolescent Neurology, Mayo Clinic, Rochester, Minnesota, USA Pérez de Ceila [email protected] Hospital Infantil Dr. Robert Reid Cabral, Ferrán Santo Domingo, Dominican Republic Peters Verena [email protected] University Children's Hospital Heidelberg, Germany Prokisch Holger [email protected] Institute of Human Genetics, School of Medicine, Technische Universität München, Munich, Germany Saada Ann [email protected] Dept. of Genetics, Hadassah Medical Center & Faculty of Medicine, Hebrew University of Jerusalem, Israel Salomons Gajja S. [email protected] Genetic Metabolic Diseases & Metabolic Unit, Amsterdam University Medical Centers, Amsterdam, The Netherlands Saudubray Jean-Marie [email protected] Paris, France

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Scarpa Maurizio [email protected] Center for Rare Diseases, Udine University Hospital, and Department of Pediatrics, University of Padua, Italy Schara- Ulrike [email protected] Department of Neuropediatrics, Schmidt University Children's Hospital Essen, Germany Schiff Manuel [email protected] Necker Hospital, APHP, Reference Center for Inborn Error of Metabolism, Pediatrics Department, University of Paris, and Inserm UMR_S1163, Institut Imagine, Paris, France Servidei Serenella [email protected] Department of Neuroscience, Università Cattolica del Sacro Cuore, Neurophysiopathology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome Smeitink Jan [email protected] Khondrion, Nijmegen, The Netherlands Suomalainen Anu [email protected] Research Program of Stem Cells and Metabolism, Faculty of Medicine; Neuroscience Center, HiLife, University of Helsinki, Finland Tangeraas Trine [email protected] Oslo University Hospital Rikshospitalet, Oslo, Norway Taylor Robert [email protected] Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle, UK Thiele Ines [email protected] Discipline of Microbiology, School of Natural Science; School of Medicine; National University of Ireland, Galway, Ireland Thorburn David [email protected] Murdoch Children's Research Institute, Melbourne, Victoria, Australia Van Hove Johan [email protected] Dept of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado, USA van der Ploeg Ans T [email protected] Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands van Clara [email protected] Dept of Pediatrics (Metabolic Diseases), Karnebeek Radboud University Medical Center & Dept of Pediatrics, Amsterdam University Medical Centers, The Netherlands Visser Gepke [email protected] Metabolic Diseases Dept, Wilhelmina Children's Hospital, Utrecht, The Netherlands Vockley Jerry [email protected] Dept of Pediatrics & Medical Genetics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA Wanders Ron [email protected] Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centre, Amsterdam, The Netherlands Webster Dianne [email protected] Auckland City Hospital, Auckland, New Zealand

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Wedell Anna [email protected] Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden Wiley Veronica [email protected] The Children's Hospital at Westmead, Wentworthville, New South Wales, Australia Wredenberg Anna [email protected] Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden Zeviani Massimo [email protected] Department of Neurosciences and Veneto Institute of Molecular Medicine, University of Padua, Italy

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Abstract

Several initiatives at establishing a classification of inherited metabolic disorders have been published previously, some focusing on pathomechanisms, others on clinical manifestations, while yet another attempted a simplified approach of a comprehensive nosology. Some of these classifications suffered from shortcomings, such as lack of a mechanism for continuous update in light of a rapidly-evolving field, or lack of widespread input from the metabolic community at large. Our classification (the International Classification of Inherited Metabolic Disorders, or ICIMD) includes 1,450 disorders, and differs from prior approaches in that it benefited from input by a large number of experts in the field, and was endorsed by major metabolic societies around the globe. Although several criteria such as pathway involvement and pathomechanisms were considered, the main purposes of the ICIMD remain clinical and didactic. As new disorders are discovered, we will seek the opinion of experts in the different advisory boards prior to inclusion in the appropriate group of the ICIMD, thus guaranteeing the continuing relevance of this classification via regular curation and expert advice.

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Introduction

The first attempt at classifying inherited metabolic disorders dates back to 1960, with the publication of the first edition of “The metabolic basis of inherited disease” (Stanbury et al. 1960). In that book, ten groups of disorders were defined, affecting the metabolism of carbohydrates, amino acids, lipids, steroids, purines and pyrimidines, metals, porphyrins, blood and blood-forming tissues, renal tubular transport, and plasma proteins, respectively. Several classification systems have been proposed since then, including a classification based on pathomechanisms, in four groups affecting transport, scavenging and secretion, synthesis, and intermediary metabolism, respectively (Sinclair 1982). A clinical classification is also available, dividing disorders into those involving single organ systems versus multisystemic presentations, the latter in turn subdivided into disorders of complex molecules, intoxication disorders, and energy deficiency disorders (Saudubray and Charpentier 2014). A hierarchical classification was established by the Society for the Study of Inborn Errors of Metabolism (SSIEM), with groups of disorders assigned according to the specific biochemical pathway involved (Zschocke 2014). A recently proposed nosology included greater than one thousand well-established diseases and more than 100 provisional ones, divided in 130 groups (Ferreira et al. 2019). A practical simplification of this nosology was subsequently suggested (Saudubray et al. 2019).

Why should one bother about structured disease classification at a time of complex electronic databases that allow easy access to, and plenty of interconnections between, a large number of entries? The primary aim of any classification is probably to structure one’s thoughts and approach in order to improve our understanding of large datasets. This is the reasoning behind the “International Classification of Inborn Metabolic Disorders” (ICIMD) presented here. It is an attempt to group almost 1500 monogenic diseases whose underlying pathophysiology may be regarded as “metabolic” into a hierarchical structure that can serve as a basis for didactic purposes (including textbooks and seminars), electronic resources, other existing disease databases, patient registries, rare disease initiatives, and many other purposes. For registration of affected individuals and epidemiological studies it is very important to adhere to a uniform classification, otherwise it is difficult to know the exact prevalence of a particular condition. An ontological system makes it much easier to understand and remember individual conditions through the knowledge of the common clinical features and diagnostic strategies for whole groups of disorders. The primary benefit of an ICIMD thus should be for teaching, understanding and clinical decision making with regard to inherited metabolic disorders.

Starting with a kick-off meeting at the Annual Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM) in Athens 2018, the strategy was to combine knowledge and opinions 8 from a large number of stakeholders throughout the world and to seek endorsement by international professional societies. The proposed ICIMD was to be combined with existing databases and nosologies. A classification is irrelevant if there is no strategy for long-term maintenance, e.g., through support of the international scientific community. A broad process with general consensus, authorization and maintenance by international societies worldwide, was regarded as the best way to create a useful and lasting structure. The result of this process is presented here.

Methods

Definition of “inherited metabolic disorders”

We opted to use the nomenclature “inherited metabolic disorders”. Here, we use the term inherited to account for traits that are determined genetically, regardless of whether the genetic material was inherited from a parent or appeared de novo. In the great majority of cases, these traits are also inborn, meaning they are present at the time of birth. However, in rare occasions we decided to also include somatic diseases, either when they can be associated with abnormalities in standard biochemical tests (as is the case with somatic mutations in IDH1 leading to D-2-hydroxyglutaric aciduria), or when these diseases lead to disease manifestations commonly encountered by metabolic physicians (such as for example in the setting of hyperinsulinism caused by somatic activating variants in AKT2).

What defines metabolism? We decided to use an inclusive approach, covering any condition in which the impairment of a biochemical pathway is intrinsic to the pathophysiology of the disease, regardless of whether there are abnormalities in currently available biochemical laboratory tests (Morava et al. 2015).

We abstained from using the term “errors” in order to avoid negative connotations. The choice between diseases and disorders was somewhat more nuanced. The rather broad term “disorder” describes basically any deviation from normal physical function, whereas “disease” is usually thought to make assumptions about the presence of signs or symptoms, in line with the notion, for example, of histidinaemia as a “non-disease” as lack of histidine ammonia-lyase has no known health consequences. However, it is impossible to exclude the possibility of clinical effects of any biochemical trait under all circumstances. Combined malonic and methylmalonic aciduria (CMAMMA) was originally reported to cause a clinically severe phenotype (Sloan et al. 2011) but is associated with normal development in the majority of individuals identified by newborn screening of urinary metabolites (Levtova et al. 2019). Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency remains asymptomatic in many individuals (Zschocke et al. 2001), but was associated with 9 a 20-25% mortality in the pre-newborn screening era (Wilson et al. 1999). The proposed heterozygote advantage of phenylketonuria (PKU) mutation carriers (Woolf et al. 1975; Krawczak and Zschocke 2003) reflects the possibility that even carrier status may have clinical effects under specific conditions. Thus, basing the term “disease” on purely clinical rather than functional criteria appears difficult. Another approach to the terms “disease” and “disorder” focuses on the knowledge of the specific aetiology of a condition. In this concept, any condition that has an impact on the body's normal homeostatic processes and has a defined cause, e.g., a monogenic condition caused by altered or absent function of a specific gene product, is denoted a “disease”. In contrast, the term “disorder” is used for a more general functional abnormality or disturbance that does not have a single precise cause. The metabolic syndrome, for example, is a disorder, not a disease. We have decided to combine these definitions for the ICIMD. In this context, “diseases” are defined as disturbances of metabolic functions that (a) are clinically significant, i.e., cause clinical symptoms and signs at least in certain circumstances, and (b) have a specific cause or pathogenesis, which in the context of the ICIMD equates to known or presumed altered function of a single gene product. Thus, we use the term “disorder” to cover any type of metabolic alteration, or general disturbances of pathways that may be caused by a range of genetic (or non-genetic) alterations. The more specific term “disease” is reserved for those conditions that have a defined clinical presentation and pathogenesis. The suspected diagnosis of, e.g., a urea cycle “disorder” is easily made by biochemical testing in a patient but still requires the exact identification of the specific “disease”.

Method of generating the ICIMD

We chose certain criteria when designing our classification system. Different degrees of disease severity were considered as a single entity, and not broken down into subtypes. In cases of locus heterogeneity (multiple genes associated with the same phenotype) the involvement of each gene product was considered as the basis for inclusion. This has consequences for the nomenclature, as in these cases, diseases are named by the causative gene product, not by their clinical presentation. This is particularly relevant for the syndromic mitochondrial disorders. For example, the disease entity “mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes” (MELAS syndrome) is not listed in the ICIMD as such but rather by several mt-DNA encoded transfer RNA (tRNA) and respiratory chain subunits deficiencies. Leigh syndrome, the most frequently observed phenotype of mitochondrial disease in childhood, may be caused by approaching 100 different monogenic disorders involving mtDNA-encoded and nuclear genes (Rahman et al. 2017). Future revisions of the ICIMD may develop a system of including specific phenotype descriptions associated with variants in several genes in an ontological fashion. In cases of allelic heterogeneity (multiple phenotypes associated with the same gene), different pathomechanisms were considered necessary

10 for separation into different entries. We decided to include disorders (143 in total) even if they remain provisional, i.e., have only been reported in a single family so far, or have not been confirmed at a molecular level. In many cases, diseases could easily be ascribed to more than one metabolic pathway or group; in such instances (about 10% of all disorders in the ICIMD), we picked the pathway which we judged most appropriate and cross-reference diseases in the other group(s).

Whenever possible, we attempted to use already established metabolic databases (such as the KEGG Pathway Database) as the default basis for the ICIMD, but adapted it for clinical purposes where necessary. For example, the KEGG database lists the citric acid cycle under the category of carbohydrate metabolism, whereas we included it under the category of energy substrate metabolism, as this seems more appropriate for clinical and didactic purposes. Similarly, glycerol kinase deficiency has previously been included under the category of “disorders of glycolysis and the pentose phosphate pathway” (Saudubray et al. 2016), or disorders of glycerol metabolism included under the category of lipid disorders (Ferreira et al. 2019) or organic acidurias (McCabe 2019). Although each of the aforementioned approaches had their own rationale (glycerol is a polyol, it is a precursor for the synthesis of triglycerides and glycerophospholipids, and glycerol kinase deficiency can be detected by urine organic acid analysis), we decided to include this enzyme deficiency under the category of disorders of gluconeogenesis. This is because glycerol kinase participates in the conversion of glycerol into a gluconeogenic substrate, and this more easily explains the manifestations of hypoglycemia and metabolic acidosis seen in glycerol kinase deficiency. This example emphasizes once more our pursuit towards a clinical and didactic goal for the ICIMD.

Results

The ICIMD includes 1,450 disorders divided in 23 groups (see figure 1). The first 12 groups comprise the disorders of intermediary metabolism. For the purpose of this classification, we defined intermediary metabolism as follows:

a. the full set of reactions that transform nutritive material into energy storage compounds, reducing equivalents, and biosynthetic intermediates; b. the metabolites involved in these reactions are required to be of low-molecular weight, thus excluding macromolecules; and c. it is circumscribed to anabolism/catabolism of nutrient small molecules (excluding non- nutrient ones).

In other words, disorders of intermediary metabolism involve pathways that mediate the breakdown of low-molecular weight nutrient compounds belonging to one of the three major energy substrates 11

(proteins, carbohydrates, and lipids) or convert them into substrates for the biosynthesis of complex molecules. Intermediary metabolism in the definition used here includes energy metabolism based on mitochondrial oxidative phosphorylation which covers groups 5-11 in the ICIMD. We have loosely followed the “rational genetic classification” of mitochondrial disorders originally proposed by Salvatore DiMauro (DiMauro 2011). This progressively evolved over the years with the discovery of new classes of mitochondrial disorders affecting mitochondrial DNA (mtDNA) maintenance and gene expression, import, dynamics, cofactor biosynthesis and quality control. We decided to separate the mtDNA-related from the nuclear-encoded disorders impacting oxidative phosphorylation because of differences in genetic mechanisms, clinical presentation and diagnostic approaches.

Groups 13 and 14 represent disorders of lipid metabolism and transport, whereas the disorders of heterocyclic compounds (nucleotides and tetrapyrroles) are listed in groups 15 and 16. Groups 17-19 comprise disorders affecting the metabolism of complex macromolecules and organelles; they include disorders of glycan metabolism (including the congenital disorders of glycosylation but excluding disorders of glycogen metabolism), the biogenesis and interaction of organelles, and complex molecule degradation (including lysosomal disorders). In contrast to other metabolic classifications and textbooks, the ICIMD does not have a single chapter on peroxisomal disorders as the enzymes in this organelle have rather diverse functions leading to very different clinical presentations. Most peroxisomal disorders affect lipid metabolism and are located in group 13 whereas peroxisomal biogenesis disorders are listed in the respective group 18. Also in that group are the disorders of lysosome-related organelle biogenesis which mostly have a different clinical presentation to the other lysosomal disorders.

Disorders of the metabolism of cofactors and minerals (including vitamins and trace elements) are collected in groups 20 and 21. These disorders have the potential to affect multiple aforementioned pathways, as they are necessary for a variety of enzymatic (and sometimes non-enzymatic) reactions.

Vitamins and cofactors that are relevant for single pathways only (e.g. coenzyme Q10 and lipoic acid in mitochondrial disorders) are positioned in the respective group. Finally, disorders of neurotransmitter and endocrine metabolism are provided as disorders of metabolic cell signaling in groups 22 and 23.

1) Disorders of amino acid metabolism

This rather large group comprises many of the traditional “metabolic disorders” which are identified by standard “metabolic investigations” such as amino acid and organic acid analysis and are often amenable to dietary treatment. Deficiencies of enzymes involved in amino acid metabolism frequently result in the accumulation of toxic substances and subsequent organ damage. Acute

12 symptoms are often associated with catabolic states that lead to the breakdown of endogenous proteins. Most subgroups are based on (common) metabolic pathways of specific amino acids. An exception is the group of the organic acidurias which we define as deficiencies of mitochondrial enzymes required for the breakdown of coenzyme A (CoA)-activated small carboxylic acids mostly resulting from deamination of amino acids. Disorders of amino acid transport are also included here.

2) Disorders of peptide and amine metabolism

This small but diverse group of disorders covers deficiencies of enzymes involved in the biosynthesis and regeneration of glutathione, as well as dipeptidase deficiencies and disorders of methylamine and polyamine metabolism.

3) Disorders of carbohydrate metabolism

Subgroups include the disorders of galactose and fructose metabolism; gluconeogenesis, glycogen metabolism, and glycolysis; pentose/polyol metabolism; and hexose transmembrane transport and absorption.

4) Disorders of fatty acid and ketone body metabolism

Clinically, mobilisation of stored triglycerides (lipolysis) during fasting results in the hepatic production of ketone bodies which serve as an energy source particularly for muscle and brain, the latter with a high energy demand but a limited ability to oxidise fatty acids. Consequently, this group includes the disorders of mitochondrial fatty acid oxidation, carnitine metabolism, and ketone body synthesis, breakdown and transport.

5) Disorders of energy substrate metabolism

The products of amino acid, carbohydrate, and lipid breakdown are transported into the mitochondria where they serve as substrates for adenosine triphosphate (ATP) synthesis by the process of oxidative phosphorylation. We have combined the disorders of pyruvate metabolism and the Krebs cycle as well as creatine metabolism under the term “energy substrate metabolism”; however, pyruvate carboxylate deficiency is positioned in the “disorders of gluconeogenesis” subgroup because of biochemical functional and clinical reasons.

6) Mitochondrial DNA-related disorders

The first mitochondrial disorders defined genetically involved deletions and point mutations of the mtDNA. As the mtDNA has a different inheritance pattern to the nuclear genome, and clinical expression of pathogenic mtDNA variants is influenced by mtDNA heteroplasmy, biochemical threshold for the specific variant and its tissue segregation, we have elected to list the 37 mtDNA-

13 encoded genes together as one group. Three subgroups encompass disorders associated with the 13 protein-coding genes, the genes encoding mitochondrial tRNAs and rRNAs, and the disorders associated with single large-scale mtDNA deletions.

7) Nuclear-encoded disorders of oxidative phosphorylation

This group of disorders includes deficiencies of nuclear-encoded subunit components as well as assembly factors of the five oxidative phosphorylation complexes, which are generally (although not invariably) associated with isolated deficiency of a single enzyme complex in affected tissue(s).

8) Disorders of mitochondrial cofactor biosynthesis

Here we have included disorders affecting the intramitochondrial biosynthesis of the following cofactors: coenzyme Q10 (ubiquinone), lipoic acid, iron-sulphur clusters and cytochrome c. These disorders have been separated out from the main group of vitamin and cofactor metabolism deficiencies because they are expressed exclusively in the mitochondrion.

9) Disorders of mitochondrial DNA maintenance and replication

In this category there are two subgroups: proteins needed for mitochondrial nucleotide pool maintenance and those essential for mtDNA replication and maintenance.

10) Disorders of mitochondrial gene expression

This rapidly expanding group of now more than 60 conditions includes disorders of mitochondrial transcript processing and modification, aminoacyl-tRNA synthetases and the mitoribosome.

11) Other disorders of mitochondrial function

In this group we have included disorders of mitochondrial shuttles and carriers (with cross- referencing to some mitochondrial carriers that are included elsewhere in our classification), disorders of mitochondrial protein import, disorders of mitochondrial protein quality control, and miscellaneous mitochondrial disorders that do not fit in the above categories, or whose function has not been established conclusively.

12) Other disorders of intermediary metabolism

In this group we included disorders of glyoxylate and oxalate metabolism as these can derive from a range of metabolites including amino acids (hydroxyproline, glycine, serine), ascorbic acid, and others. In addition, we defined a subgroup of disorders of metabolite proofreading as these involve addressing the promiscuity of certain enzymes of intermediary metabolism (such as those in the Krebs cycle).

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13) Disorders of lipid metabolism

For the classification of disorders of lipid metabolism, we tried to follow as closely as possible an already-established and well reputed classification system for lipids, LIPID MAPS® (Fahy et al. 2005, 2009). Thus, we include groups for disorders of the metabolism of fatty acyls (with peroxisomal fatty acid oxidation disorders as a distinct subgroup), glycerolipids, glycerophospholipids, sphingolipids, and sterol lipids (the latter including sterols and bile acids). Fatty acyls include fatty acids, fatty aldehydes, and eicosanoids. However, we decided to diverge from this previously established lipid classification for didactic purposes, as mitochondrial fatty acid oxidation disorders are better included under intermediary metabolism, glycolipids (glycosylphosphatidylinositol and glycosphingolipids) are included under the category of congenital disorders of glycosylation, and prenol lipids are included as ubiquinones (disorders of coenzyme Q10 biosynthesis under mitochondrial cofactor biosynthesis in group 8), vitamin E and K are included under other disorders of vitamin metabolism, and polyprenols in disorders of dolichol metabolism under congenital disorders of glycosylation.

14) Disorders of lipoprotein metabolism

The disorders that affect lipid transport are divided into different subgroups based on the type of lipid anomalies manifest in the blood, and other functional aspects. They include the hypercholesterolemias, hypertriglyceridemias, mixed hyperlipidemias, disorders of high-density lipoprotein (HDL) metabolism, disorders with decreased low-density lipoprotein (LDL) and/or triglycerides, and other disorders of lipoprotein metabolism.

15) Disorders of nucleobase, nucleotide and nucleic acid metabolism

The group of pyrimidine and purine metabolism disorders includes disorders in the de novo synthesis, salvage and breakdown of nitrogenous bases, nucleosides and nucleotides. We then include disorders of ectonucleotides and nucleic acids (polymers of nucleotides), non-mitochondrial tRNA and rRNA metabolism.

16) Disorders of tetrapyrrole metabolism

Under the category of tetrapyrroles we include disorders of porphyrins (heme biosynthetic disorders), as well as disorders involving the products of heme breakdown (biliverdin and bilirubin). Although corrin also represents a tetrapyrrole, disorders involving corrin metabolism are discussed elsewhere (as disorders of cobalamin metabolism).

17) Congenital disorders of glycosylation

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Many proteins and lipids require the attachment of carbohydrates to render them functional. The Congenital Disorders of Glycosylation (CDG) are divided into disorders affecting N-linked and O- linked protein glycosylation (including glycosaminoglycan synthesis), disorders of lipid glycosylation (including the disorders of glycosylphosphatidylinositol biosynthesis), and disorders with the potential to affect multiple glycosylation pathways (dolichol metabolism, Golgi transport and homeostasis, sialic acid metabolism, and others).

18) Disorders of organelle biogenesis, dynamics and interactions

Disorders that affect the biogenesis and interaction of organelles are usually difficult to link to specific metabolic pathways and often cause diverse clinical manifestations. To address this, we decided to create a separate group which includes disorders of mitochondrial membrane biogenesis and remodelling, mitochondrial and peroxisomal dynamics, peroxisomal biogenesis (the peroxin- related peroxisomal disorders), lysosome-related organelle biogenesis, organelle interplay, and vesicular trafficking.

19) Disorders of complex molecule degradation

This group comprises what is generally known as lysosomal disorders –such as the disorders of sphingolipid, glycosaminoglycan, or glycoprotein degradation and the neuronal ceroid lipofuscinoses– as well as the disorders of autophagy and some other disorders.

20) Disorders of vitamin and cofactor metabolism

Vitamins and cofactors relevant for various metabolic pathways include tetrahydrobiopterin, thiamine (vitamin B1), riboflavin (vitamin B2), niacin and nicotinamide (vitamin B3), pantothenate

(vitamin B5) and coenzyme A, pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9), cobalamin (vitamin B12), molybdenum cofactor, and others. The cofactors coenzyme Q10, lipoic acid and iron-sulphur clusters are grouped under mitochondrial disorders.

21) Disorders of trace elements and metals

We included disorders of the metabolism of copper, iron, manganese, and zinc.

22) Neurotransmitter disorders

The ICIMD contains a specific category of disorders of neurotransmission, given the increased attention and scrutiny that these disorders have encountered in the metabolic community in recent years (Cortès-Saladelafont et al. 2016; Tristán-Noguero and García-Cazorla 2018). Well known “metabolic” neurotransmitter disorders that are recognized by the analysis of cerebrospinal fluid affect monoamines and gamma-aminobutyric acid. This group also includes disorders that affect the

16 neurotransmitter function of specific amino acids (glutamate, glycine) and choline, as well as disorders of the synaptic vesicle cycle.

23) Endocrine metabolic disorders

Our last group highlights the link between some metabolic and endocrine disorders. In this group we included disorders affecting insulin metabolism (because of the overlap with the clinical presentation, e.g., of fatty acid oxidation disorders) and disorders of steroid hormones (derived from sterol lipids).

Discussion

Classifying a large number of metabolic diseases with a diverse genetic and pathogenic basis and almost any imaginable clinical presentation into a single hierarchical structure is an impossible task and can only be partially achieved, and only then by cutting many corners. The core unit of the ICIMD is the clinical or biochemical phenotype linked to a particular gene that defines a particular “monogenic” condition. The different genetically defined diseases are grouped according to metabolic pathways which usually share pathogenetic mechanisms and often give rise to related clinical presentations and are frequently recognized by the same biochemical-diagnostic strategies. Inherited metabolic disorders may be understood and learned by understanding the functional consequences of disturbances in different biochemical pathways, and identifying the individual disease in a second step. To aid this, we have also mapped ICIMD disorders onto 250 of the 255 inborn errors of metabolism captured in the Virtual Metabolic Human database (VMH.life) (Noronha et al. 2019) as well as to 767 of 3,288 (23%) genes present in the human metabolic reconstruction, Recon 3D (Brunk et al. 2018) (Figure 2).

Clearly there are limits to this strategy as the concept of a “monogenic” inheritance pattern is often difficult to maintain. Disease manifestation may depend on more than one particular gene, there may be more than one causative gene for a clinically and biochemically defined condition, or different (e.g., loss-of-function vs. activating) mutations in the same gene may cause very different phenotypes. Nevertheless, there are ways to allow for these exceptions, e.g., by defining gene-based disease subtypes for conditions that may be caused by mutations in more than one gene. If a disease may have quite variable presentation in different patients it is generally regarded as a single condition in the ICIMD, regardless of the spectrum of associated severities.

The main reasoning behind this approach is that within the huge variety of “diseases” linked to specific “clinical presentations”, genes and their associated spectrum of clinical phenotypes are

17 objective natural entities, reflected in, and linking to, many other genetic databases. Also, gene variants have become the main entry point into the diagnosis of rare diseases made by genome-wide sequencing technologies. In the new “reverse Medical Genetics” era, it is essential to understand the spectrum of clinical effects that variants in the same gene may cause. We therefore argue that a gene-/aetiology-centred scaffold logically intertwined with the clinical classification is essential for the success of a disease classification. With the ICIMD we have attempted to create a logical, hierarchical network of specific genes and specific diseases (encompassing clinical spectra and subtypes). In most instances this is a 1:1 relationship, but in some cases there is a 2/3/n:1 or 1:2/3/n relationship. This should not be considered a shortcoming of our classification, as long as classification users are aware of this approach. Genes, proteins or gene functions are part of hierarchical networks or pathways, and the same is true for diseases and disease groups. The presentation of these complex relationships should not constitute a problem, as long as the core units of “genes” and “disease” provide the essential scaffold.

The results presented here clearly represent a “work in progress” which presumably – and hopefully – will never end. For many metabolic pathways most of the “expected” monogenic conditions have by now been identified. However, there are still more protein-coding genes in the human genome without an associated clinical phenotype than known disease-causing genes. Moreover, we have not even started to fully appreciate the range of possible clinical consequences of mutations in non- protein-coding genes. The classification has been formally endorsed by the Society for the Study of Inborn Errors of Metabolism, SSIEM (www.ssiem.org), the Society for Inherited Metabolic Diseases, SIMD (www.simd.org), the Latin American Society of Inborn Errors of Metabolism and Neonatal Screening, SLEIMPN (www.sleimpn.org), the Australasian Society for Inborn Errors of Metabolism, ASIEM (www.hgsa.org.au/asiem), and the Japan Society of Inherited and Metabolic Diseases, JSIMD (http://jsimd.net/). The ICIMD has also been endorsed by the European Reference Network for Rare Hereditary Metabolic Disorders, MetabERN (https://metab.ern-net.eu/), is supported by Orphanet (www.orpha.net) and IEMbase (www.iembase.org; Lee et al. 2018), and has been adopted by the Dutch Diagnosis Registration Metabolic Diseases (DDRMD) registry (www.ddrmd.nl). We plan to maintain a long-standing commission for the continuous revision and update of the ICIMD, linked to the international metabolic societies and other public stakeholders.

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Figure Legend

Figure 1. Sunburst chart depicting the hierarchical nature of the International Classification of Inherited Metabolic Disorders (the chart was kindly provided by Dr. Markus Keller, Institute of Human Genetics, Medical University Innsbruck).

Figure 2. Metabolic map of human metabolism (Noronha et al. 2017, 2019) illustrating 8,151 of the 13,543 reactions (links) and 2,763 of the 4,140 metabolites present in the human metabolic reconstruction, Recon 3D (Brunk et al. 2018). A total of 767 of the 3,288 genes in Recon 3D could be mapped onto the genes captured in the ICIMD resource. The gene products of these 767 genes catalyze a total of 5,111 metabolic and transport reactions, which are highlighted in red, illustrating the wide metabolic distribution of inherited metabolic disorders across many metabolic pathways and subsystems (analysis and graphical representation were kindly provided by Professor Ines Thiele, Discipline of Microbiology, School of Natural Science and School of Medicine, National University of Ireland, Galway, Ireland).

21

Complex III subunits and assembly factors

Complex II subunits and assembl

and assembly factors Complex I subunits Single large-scale mtDNA deletions

me c

mtDNA Cytochro

mtDNA Creatine tRNA/rRNA

Krebs cy anscript Pyruv -encoded resp -encoded K etone bodies Mitochondrial fatt Carnitine ate synthetases y factors mtDNA tr

Carboh cle . chain proteins P Nucleotide pool maintenance Complex V subunits and assembly factors

entose/poly Complex IV subunits y and assembly factors dr Coenzyme Q10 biosynthesis and carriers ate tr Lipoic acid and iron-sulfur y acid o Gly mtDNA replication and maintenance ansport and absorption processing and modi cation ol Mitochondrial aminoacyl-tRNA Mitochondrial shuttles y controlellaneousxalate xidation phosphorylation o Miscellaneous Gly cogen Nuclear

xidativ xylate and o Gluconeogenesis mtDNA qualit o cling colysis Gly Galactose and fructose Mitoribosome Phosphatidylcholine Energy substr MitochondrialMitochondrial protein import proteinMetabolite proofreading phosphatidylserine Poly xidation Meth amine Peptides:ylamine other F y acid o -encoded Eicosanoids att e Glutathione phosphatidylethanolamine Amino y acid and k Mitochondrial dysfunction: misc acids: other Gene xisomal fatt cerolipid y acyl synthesis,Pero elongation, and recy Amino acid tr Carboh Fatt Gly Histidine Phosphatidylinositol etone bodyate Other Glu/Gln and Asp/Asn expression Ether lipids Cofactor biosynthesis ansport DNA maintenance and replication Lys, Hyl and T Other Peptide and aminey Orn, Pro and Hyp dr rp cerophospholipids Gly and Ser ate Gly Sulfur -containing AA cling Phe and T Sphingolipidand synthesis recy metabolism yr Energy Branched-chain amino acids Intermediary Amino acid Intermediary metabolism: Lipid Sterols Intermediary Bile acids Organic acidurias Nutrients metabolism: Hypercholesterolemiasceridemias Urea cy Hypertrigly cle & hyperammonemias Mixed hyperlipidemias Lipid metabolismansport HDL metabolism Decreased LDL/triglycerides and tr Lipoprotein Lipoproteins: other Steroids Endocrine Metabolism of Pyrimidines metabolism Metabolic cell heterocy Nucleobase, signaling

and organelle compounds clic Insulin ansmitter metabolism nucleotide Purines cle Ectonucleotides and

molecule esicle cy Neurotr al metabolism Complex and nucleic Synaptic v Cofactor and metabolism miner nucleic acids Choline ansmitters ansmitters Glycine neurotr non-mitochondrial ace elements acid Glutamate neurotr Tr and metals T GABA disordersCongenital of etr gly ap Monoamines yrrole RibosomaltRNA Trace element: other Vitamin and Zinc cosylation Manganese cofactor biogenesis Iron Heme synthesis and porph Heme degr Copper Complex Vitamins: other adation N-link Molybdenum cofactor molecule actions adation and bilirubin Cobalamin degr Organelle biogenesis, gly ed protein olate xine inter yrias F adation: other O-link Biotin dynamics and cosylation Pyrido Pantothenate and CoA vin Lipid gly Niacin and NAD adation drobiopterin Multiple gly y gly

Riboa Mitochondrial membr

Mitochondrial and pero Thiamineah adation adation ed protein Tetr can degr cosylation Complex molecule degr utophagy A cosylation y

Neuronal coproteinceroid lipofuscinosis degr ane biogenesis and remodeling

Gly cosaminogly cosylation

path

Gly xisomal dynamics O-mannosylation

Sphingolipid degr esicular V acking w a xisomal biogenesis

Other gl ys tr ycan meta and O-

bolism

ero Organelle interpla ysosome-related organelle biogenesis

L P GAG synthesis Gly

Golgi homeostasis

cosylphosphatidyl- xylosylation

O-fucosylation

biosynthesis

Golgi t

Dolichol inositol Other

r ansport

Other

Sialic acid

Other Lpipecol[e] na1[e]

glc_D[e]

&

na1[c] ser_L[e]

crn[c] na1[e] thr_L[c] hom_L[c] asn_L[c] leu_L[c] phe_L[c] met_L[c] gln_L[c] na1[e] gly[c] trp_L[c] tyr_L[c] cys_L[c] pro_L[c] val_L[c] ile_L[c] ala_L[c] na1[c] arachdcrn[c] pi[c] thp2c[c] fald[c] mev_R[c] ipdp[c] frdp[c] hxcoa[c] & cl[e] & & h[e] & & na1[c] & & & na1[c] & & na1[c] & & & h[c] & & na1[c] & & na1[c] & & & na1[c] & & na1[c] & adp[c] lnlccrn[c] leuktrB4[c] nad[c] ala_L[c] lnlccoa[c] CE4988[c] o2[c] Lpipecol[c] nadh[c] hmgcoa[c] fadh2[c] fad[c] crn[c] na1[c] hpyr[c] hxa[c] crn[c] HC10859[c] crn[c] atp[c] h2o[c] h[c] acrn[c] fvscoa[c] cl[c] h[c] & na1[e] & & na1[e] & & na1[e] h[e] & na1[e] & & na1[e] & & na1[e] & & na1[e] & pi[c] profvscoa[c]

na1[c] thr_L[e] hom_L[e] asn_L[e] leu_L[e] phe_L[e] met_L[e] gln_L[e] na1[c] gly[e] trp_L[e] tyr_L[e] cys_L[e] pro_L[e] val_L[e] ile_L[e] ala_L[e]

&

& &

adp[x] pi[x] ser_L[c] atp[x] nad[x] & sarcs[x] h2o[x] phe_L[c] o2[x] ipdp[x] h2o2[x] o2[x] nadh[x] 5dpmev[x] & frdp[x] & na1[x] nadp[x] adp[x] coa[x] nadh[x] o2[x] fald[x] & h2o[x] co2[x] ppi[x] h2o2[x] h2o2[x] thp2c[x] & Lpipecol[x] & 1pipdn2c[x] crn[x] o2[x] & crn[x] coa[x] nadph[x] accoa[x] atp[x] & h[x] crn[x] & h[c] h[x] co2[x] hxan[x] & xan[x] urate[x] h[x] fvscoa[x] & profvscoa[x] & 5pmev[x] coa[x] HC10859[x] malcoa[x] accoa[x] & acrn[x] gln_L[e] trp_L[e] ala_L[e] thr_L[e] leu_L[e] cys_L[e] ile_L[e] tyr_L[e] gly[e] pro_L[e] asn_L[e] val_L[e] hom_L[e] ser_L[e] met_L[e] cl[c] gly[x] & & & h2o2[x] dmpp[x] & grdp[x] nadh[x] h2o[x] h2o[x] h2o[x] adp[x] crn[x] nad[x] h[x] nadh[x] h[x] nad[x] h[x] h2o[x] fadh2[x] h[x] nadp[x] h2o2[x] h2o[x] nadh[x] h[x] nad[x] h[x] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[c] ala_D[x] fad[x] crn[x] coa[x] o2[x] & & & & & & & & & & & & & & & & & ppi[x] leuktrB4[x] & CE4990[x] & CE5944[x] & CE4988[x] crn[x] h2o2[x] h[x] o2[x] atp[x] amp[c] h2o[x] CE2421[x] & CE2434[x] & lnlccoa[x] & lnlccrn[x] coa[x] nadph[x] amp[x] & nh4[c] nh4[x] & o2[x] pi[c] adp[c] atp[c] & & & & & & & & & & & & & na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[e] h2o[x] mev_R[x] CE2440[x] & CE2439[x] h[c] h2o[c] o2[x] o2[x] nad[x] nh4[x] crn[x] coa[x] nadp[x] & nad[x] atp[c] pyr[x] atp[x] gln_L[c] trp_L[c] ala_L[c] thr_L[c] leu_L[c] cys_L[c] ile_L[c] tyr_L[c] gly[c] pro_L[c] asn_L[c] val_L[c] hom_L[c] ser_L[c] met_L[c] cl[e] lys_L[x] & 6a2ohxnt[x] nadh[x] h[x] h[x] & arachd[x] ala_L[x] o2[x] 15HPET[x] & & & accoa[x] arachd[c] hpyr[x] h[x] nadph[x] & CE4793[x] & CE4791[x] h2o[c] h2o[x] h2o2[x] h[x] nadh[x] h2o2[x] nad[x] hmgcoa[x] fadh2[x] & nadh[x] nad[x] coa[x] h[x] & nh4[x] coa[x] accoa[x] fad[x] & nadh[x] h[x] h[x] atp[x] atp[c] & nad[x] o2[x] h2o2[x] & phe_L[e] & h[x] h2o2[x] lac_L[x] arachdcrn[x] coa[x] ser_L[x] CE0713[x] & CE0849[x] & CE2433[x] CE2442[x] & CE2441[x] CE2438[x] h2o[x] glx[x] adp[x] & adp[c] glyclt[x] & & oxa[x] trp_L[c] h2o[x] CE5114[x] crn[x] h2o[c] acac[x] coa[x] nadph[x] h2o[x] udpglcur[e] o2[x] h2o2[x] h2o[x] accoa[x] h[c] pi[c] h[x] acac[c] nadp[x] nadph[x] & h2o[x] h2o2[x] adp[c] atp[c] glyclt[c] nadp[x] h[x] o2[x] & arachdcoa[c] no2[e] & & arachd[e] h2o[e] CE5116[x] & CE4795[x] & arachdcoa[x] gluside_hs[e] glx[c] amp[c] gm2_hs[e] ga1_hs[e] gln_L[e] met_L[e] gly[e] hom_L[e] val_L[e] pro_L[e] cys_L[e] phe_L[e] tyr_L[e] leu_L[e] asn_L[e] thr_L[e] ile_L[e] ala_L[e] ser_L[e] na1[c] coa[c] coa[x] oxa[e] & oxa[c] dcsptn1coa[c] h2o[e] h2o[e] h2o[e] coa[x] gm1_hs[e] aacoa[x] accoa[x] nadh[x] ppi[c] atp[c] udpglcur[c] gd3_hs[e] cl[c] cl[e] nh4[x] galgluside_hs[e] na1[c] & na1[e] & & & na1[e] & & na1[e] & & & na1[e] & & na1[e] & & na1[e] & & na1[e] & & na1[e] cl[c] h2o[x] h2o2[x] sphmyln_hs[e] c6crn[c] & o2[x] maltpt[e] & maltttr[e] & malttr[e] & malt[e] c6crn[x] 5a2opntn[c] Tyr_ggn[e] h[e] HC00822[e] h2o[x] h2o2[x] h[x] 5a2opntn[e] nadh[x] h2o2[x] orn_D[x] & 5a2opntn[x] na1[e] & na1[c] na1[c] & & na1[c] & na1[c] & & na1[c] & & na1[c] & & na1[c] na1[c] & cl[e] & & h2o[x] glc_D[e] glc_D[e] glc_D[e] crn[x] h[x] accoa[x] h[c] h2o2[x] o2[x] nad[x] nh4[x] h[x] & malt[e] CE2424[x] h[x] glc_D[e] & cspg_b[e] cspg_d[e] hspg[e] fad[x] accoa[x] coa[x] nadh[x] CE2418[x] coa[x] & h[e] h[c] glygn2[c] glygn1[c] nadh[c] ksii_core4[e] o2[x] h2o[x] coa[x] nad[x] h2o[x] fadh2[x] orn_D[c] h[c] gln_L[c] met_L[c] gly[c] hom_L[c] val_L[c] pro_L[c] cys_L[c] phe_L[c] tyr_L[c] leu_L[c] asn_L[c] thr_L[c] ile_L[c] ala_L[c] ser_L[c] na1[e] & & h[x] nad[x] arg_D[x] orn_D[e] pi[c] h[x] h2o[x] & & udp[c] cspg_a[e] & CE2432[x] & CE0785[x] & CE2422[x] nadh[x] o2[x] & 5g2oxpt[x] pcrn[c] & CE2417[x] hxa[x] CE4820[x] & h2o[c] 3hbcoa[x] coa[x] & CE4832[x] & CE4838[x] o2[x] h2o[e] & & 5g2oxpt[c] & h2o[e] h2o[e] g1p[c] pi[c] f1a[e] ha[e] & accoa[x] nad[x] nadh[x] h[c] adp[c] cspg_e[e] n2m2nmasn[e] c4crn[c] c4crn[x] h[x] nad[x] accoa[x] h2o2[x] glygn2[e] & glygn4[e] & glygn5[e] dxtrn[e] dxtrn[c] & & cspg_c[e] ksii_core2[e] coa[x] h2o2[x] o2[x] h2o[x] h2o[x] h2o2[x] arg_D[c] arg_D[e] h2o[e] & h[x] C05280[x] h[x] nad[x] CE2437[x] & lnlncgcoa[x] coa[x] h2o[e] h2o[e] h2o[c] & h2o[c] o2s[x] h[x] coa[x] & trp_L[e] & h2o[x] h2o[x] nadh[x] acald[x] & etoh[x] glc_D[e] glc_D[e] 3pg[c] nad[x] nadh[x] coa[x] crn[x] g1p[c] h2o[c] h2o2[x] & etoh[c] M02447[e] & M02449[e] & M02451[e] h[c] crn[c] b2coa[x] & atp[e] atp[c] & h2o[l] dmnoncoa[c] HC01407[x] & HC01408[x] & crn[x] nad[x] & h[x] nadh[x] h[x] coa[x] 13dpg[c] & M01966[c] h2o[c] atp[l] h2o2[x] h2o[x] nad[c] nad[x] h2o[x] h2o[x] coa[x] o2[x] HC02136[c] & glygn3[c] ggn[c] ala_L[e] C05279[x] & CE2420[x] & CE0693[x] acald[c] accoa[x] adrncoa[x] & dcsptn1coa[x] o2[x] glc_D[e] glc_D[e] h[x] coa[x] h2o2[x] h[x] & h2o[c] ppi[c] h[c] adp[l] & tetpent6coa[x] h[c] udp[c] no2[c] pi[l] ppcoa[c] ppcoa[x] & pcrn[x] nadh[x] accoa[x] h[x] h2o[e] h2o[c] & utp[c] & h[x] accoa[x] nad[x] h2o[e] h2o[e] & tetpent6coa[c] fru[c] coa[x] coa[x] h2o2[x] nadh[x] & & o2[x] h2o[c] adp[c] o2[x] strch1[e] & strch2[e] & malt[e] & glc_D[e] h2o[l] nad[x] coa[x] nadh[x] o2[x] coa[x] o2[x] & & atp[c] udpg[c] h[l] atp[l] crn[x] h2o[x] nadh[x] h[x] nadh[x] CE2839[c] & CE2838[c] Tyr_ggn[c] g1p[c] pi[c] h[c] nad[x] h2o[x] nadh[x] o2[x] nad[x] h2o[x] & & asp_D[c] asp_D[x] h2o2[x] h2o[c] na1[e] gly[c] thr_L[c] asn_L[c] leu_L[c] tyr_L[c] trp_L[c] ser_L[c] na1[e] cys_L[c] met_L[c] phe_L[c] pro_L[c] val_L[c] hom_L[c] ile_L[c] na1[e] asp_D[e] 3decdicoa[x] 2decdicoa[x] & octe5coa[x] & hexe3coa[x] hx2coa[x] & btcoa[x] & hxcoa[x] & HC01406[x] o2[x] coa[x] glc_D[e] glc_D[e] h2o2[x] nadh[x] h2o[x] h2o[x] h2o[c] ump[c] & h[c] o2[x] coa[x] & nad[x] & tre[c] maltttr[e] sphmyln_hs[l] na1[e] h2o[x] coa[x] coa[x] nad[x] h[x] & h[c] nadp[x] h2o[x] nad[x] h2o2[x] sphmyln_hs[c] & h[c] & & na1[c] & & na1[c] & & na1[c] & & & cl[e] & & & na1[c] & & na1[c] & & na1[c] & & h[e] & h2o[x] accoa[x] o2[x] na1[c] & tmuncoa[x] & dmnoncoa[x] & dmnoncrn[x] dmnoncrn[c] coa[x] accoa[x] h2o[e] h[e] h[x] h2o[x] & occoa[x] occoa[c] h2o[e] h2o[e] na1[c] adp[c] glc_D[c] h2o[c] crn[x] nad[x] h2o2[x] o2[x] h2o[x] coa[x] cs_a_deg1[l] pi[c] h[c] h2o[c] k[c] k[e] nadh[x] nadh[x] coa[x] & coa[x] crn[x] h[c] cholp[l] pi[c] h[c] nh4[x] h2o2[x] coa[x] nad[x] accoa[x] CE2838[e] & M02446[e] & M02447[e] tre[e] pi[c] fru[c] cholp[e] & h[e] & na1[e] & na1[e] & & na1[e] & cl[c] & na1[e] & & na1[e] & & na1[e] & h[c] h[x] ppcoa[x] & h[x] nadh[x] nad[x] nadh[x] h2o[x] nadh[x] maltttr[c] cholp[c] h2o[l] so4[l] atp[c] adp[c] fad[x] h2o2[x] accoa[x] & h2o[l] atp[c] adp[c] nadh[x] crn[x] c8crn[x] & c8crn[c] malttr[c] h[x] stcoa[x] & arachcoa[x] & ttccoa[x] & & glcur[l] h[x] h2o2[x] fadh2[x] h[x] h[c] na1[c] & h2o[l] acnam[l] so4[l] acgam[l] h[l] oaa[c] oaa[x] accoa[x] & accoa[x] h[e] h2o[c] h2o[l] h[l] h2o[l] gal[l] h2o[l] so4[l] gal[l] so4[l] h2o[l] HC02201[c] & HC02201[e] na1[c] gly[e] thr_L[e] asn_L[e] leu_L[e] tyr_L[e] trp_L[e] ser_L[e] na1[c] cys_L[e] met_L[e] phe_L[e] pro_L[e] val_L[e] hom_L[e] ile_L[e] na1[c] accoa[x] & accoa[x] accoa[x] h2o2[x] glc_D[e] glc_D[e] & C01747[c] C01747[l] acgal[l] & h[l] h2o[l] h2o[l] h2o[l] acgam[l] h2o[l] ocdca[c] & ocdca[e] h[x] h[c] h2o2[x] & h2o[c] h2o[c] gal[l] h[l] & o2[x] accoa[x] & & h[x] nadh[x] h2o[x] h[x] nad[x] h[x] nad[x] o2[x] h2o[x] pi[c] accoa[x] h[e] h2o[c] & & h2o[l] h2o[c] h2o[c] nadh[x] h2o2[x] & pi[c] h[c] h2o2[x] nadph[x] nad[x] nadh[x] nad[x] accoa[x] crn[c] h2o[e] sphings[c] sphings[l] ksii_core2[l] ksii_core2_deg4[l] ksii_core4_deg4[l] & ksii_core2_deg5[l] & ksii_core2_deg6[l] & ksii_core2_deg7[l] pi[c] h[c] h[x] nadh[x] nadh[x] o2[x] h2o2[x] h[x] na1[e] & ksii_core2_deg1[l] & ksii_core2_deg2[l] & ksii_core2_deg3[l] & coa[x] nad[x] nadh[x] na1[e] h2o[c] h[l] & atp[c] adp[c] atp[c] adp[c] h[x] nadh[x] Starch and sucrose fru[c] fru[c] cs_a_deg3[l] & cs_a_deg2[l] h2o[l] h2o[l] acgam[l] glcur[l] h2o[l] nadh[x] h[x] h2o[x] h2o2[x] udpg[e] & g1p[e] atp[c] glc_D[e] h2o[l] HC01405[x] h2o[e] h2o[e] Rtotal[c] & h[x] adp[c] tmndnccoa[x] tmndnccoa[c] Rtotal[l] acgal[l] h2o[l] & ksii_core2_deg8[l] M00019[c] M00019[e] nad[x] o2[x] & & malt[e] malt[c] h[l] so4[l] h[l] HC02200[c] & HC02200[e] & & dectricoa[x] tetdecdicoa[x] & 3ddecdicoa[x] 2ddecdicoa[x] & dece4coa[x] & dec24dicoa[x] dece3coa[x] accoa[x] ump[e] h2o[l] ha_pre1[l] & ha_deg1[l] & ha[l] & h2o[x] malthp[e] & malthx[e] & maltpt[e] & h2o[l] h[l] & h2o[l] h2o[c] h2o[x] nad[x] & coa[x] accoa[x] & & so4[l] ksii_core4_deg4[l] so4[l] acgam[l] acgam[l] glcur[l] HC02199[c] ala_L[c] nad[x] h2o2[x] coa[x] h[x] fru[c] h2o[c] so4[l] & h2o[c] pi[c] h[c] & & h2o[l] h[l] h2o[l] & & acgam[l] coa[x] nadh[x] coa[x] accoa[x] h2o[c] nad[x] sgalside_hs[c] sgalside_hs[l] acnam[l] gal[l] h[l] h[l] h2o[l] pi[c] h[c] atp[c] adp[c] nad[x] h[x] h[x] h[x] nadph[x] nadp[x] & h2o[l] h2o[l] so4[l] h2o[l] h2o[l] h2o[l] acgam[l] coa[e] & dpcoa[e] h2o2[x] & glc_D[e] glc_D[e] h2o[c] idour[l] & ksii_core2_deg4[l] gal[l] h2o[l] gal[l] udpacgal[l] coa[x] nad[x] o2[x] 3ohodcoa[x] h2o[x] nad[x] & h2o2[x] h2o[e] h2o[c] h2o[l] so4[l] h2o[l] acgam[l] h[l] atp[c] adp[c] h2o2[x] h[x] & h2o[c] fru[c] fru[c] h2o[c] fru[c] h2o[c] h2o[l] h2o[l] pro_L[e] mal_L[x] h[x] h[x] h2o[x] acgam[l] vacc[c] & vacc[e] o2[x] pi[c] h2o[x] atp[c] coa[x] & cs_a[l] & cspg_a[l] ksii_core4[l] & ksii_core4_deg1[l] & ksii_core4_deg2[l] & ksii_core4_deg3[l] h2o[e] h2o2[x] nad[x] CE2839[e] CE2838[e] crm_hs[l] ksii_core2_deg9[l] & f1a[l] & core6[l] & Tn_antigen[l] & Ser_Gly_Ala_X_Gly[l] pi[e] h2o[e] o2[x] & & HC02199[c] & HC02199[e] h2o[c] h2o[x] h2o[x] & adp[c] & coa[x] nadh[x] accoa[x] CE2838[c] & M02446[c] & M02447[c] & M02449[c] & M02451[c] gal[l] h[c] coa[x] h2o[x] o2[x] HC01415[x] h[x] nadh[x] h2o[x] h[l] pi[c] h[c] accoa[x] & h[l] so4[l] udp[l] o2[x] & accoa[x] nad[x] & h2o[c] so4[c] h2o[l] & h2o[c] & pristcoa[x] & nadh[x] o2[x] so4[l] & h[l] so4[l] pi[c] h[c] atp[c] adp[c] CE5934[x] & C07297[x] & tmtrdcoa[x] pristcoa[c] pmtcrn[x] coa[x] glc_D[e] fru[c] & h[l] so4[l] h[l] h[l] xolest2_hs[l] HC02216[e] hco3[c] HC02217[e] nad[x] o2[x] h2o2[x] coa[x] & pmtcoa[x] & h2o[x] h[l] so4[l] udp[l] hco3[e] HC02214[e] hco3[c] hco3[c] HC02206[e] hco3[c] HC02202[e] hco3[c] bildglcur[e] hco3[c] triodthy[e] hco3[c] HC02198[e] h2o[x] h[x] o2[x] & cs_b_deg1[l] h2o[l] h2o[l] acgam[l] h2o[l] CoA hco3[c] prostge1[e] HC02197[e] & dc2coa[x] coa[x] acgam[l] acgam[l] & h2o[e] atp[c] adp[c] coa[x] h2o2[x] dec47dicoa[x] 2hexdtricoa[x] h[x] o2[x] nadh[x] coa[x] galside_hs[c] HC02220[e] hco3[c] HC02180[e] M00115[c] M00115[e] nad[x] nadh[x] accoa[x] atp[c] h2o[x] adp[c] pi[l] so4[l] & & & hco3[c] cl[e] ala_L[c] tyr_L[c] trp_L[c] phe_L[c] ser_L[c] cys_L[c] ile_L[c] thr_L[c] val_L[c] asn_L[c] hom_L[c] gly[c] leu_L[c] gln_L[c] asp_L[c] met_L[c] arg_L[c] h[x] coa[x] nad[x] h2o2[x] coa[x] galside_hs[l] h2o[l] h[l] HC02194[e] prostgi2[e] o2[x] nadh[x] h2o[c] nad[x] nadh[x] & accoa[x] coa[x] o2[x] h2o[x] h2o[x] cs_a_deg4[l] xolest2_hs[e] & Rtotal[e] h[e] o2[e] h[e] & &HC02208[e] &wharachd[e] HC02187[e] h2o[c] h2o[l] amp[e] h2o[e] bilglcur[e] HC02210[e] & & HC02204[e]& & & & & &HC02196[e]& & gthrd[c] & gthrd[e] pi[c] h[c] h[e] coa[x] 3ohxccoa[x] & pnto_R[e] HC02213[e]& coa[x] h[x] pi[c] h2o[l] h2o[l] & ksi_deg39[l] udpacgal[l] tchola[e] & & hco3[c] hdca[x] & pmtcoa[x] & tdcoa[x] & HC01412[x] & 3htdcoa[x] & 3otdcoa[x] nad[x] ksi_deg30[l] & ksi_deg31[l] & ksi_deg32[l] & ksi_deg33[l] & ksi_deg34[l] & ksi_deg35[l] & ksi_deg36[l] & ksi_deg37[l] & ksi_deg38[l] & & ksi_deg40[l] & ksi_deg41[l] & m2mn[l] thyox_L[e] & atp[c] adp[c] na1[e] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[e] amp[x] h[x] crn[x] adp[c] & nadh[x] o2[x] gal[c] h2o[l] HC02195[e] & h2o[c] & & & & & & & & & & coa[x] occoa[x] & 3odcoa[x] h[c] nad[x] & strdnccoa[x] h2o[c] & h[e] chsterol[e] pan4p[e] & ptth[e] & cysam[e] & hyptaur[e] & & & & pi[c] h[c] ppi[x] nad[x] & gal[l] & adp[l] so4[l] h2o[l] so4[l] so4[l] h2o[l] gal[l] h2o[l] & ppcoa[x] & nad[x] strdnccoa[c] h2o[l] Ser_Gly_Ala_X_Gly[l] gal[l] h2o[l] h2o[l] acgam[l] gal[l] h2o[l] h2o[l] acgam[l] h2o[l] gal[l] h2o[l] h2o[l] acgam[l] h2o[l] gal[l] h2o[l] acgam[l] & & s9856 s9855 & nadh[x] h[x] accoa[x] h[x] h[x] h2o[x] o2[x] so4[l] h[l] h[l] h[l] acgam[l] Ser_Thr[l] hco3[c] atp[c] adp[c] lneldc[c] & lneldc[e] h2o[x] coa[x] h2o[x] h[x] nadh[x] gchola[e] acgal[l] o2[x] & accoa[x] atp[c] digalside_hs[c] acgal[l] h2o[c] amp[c] h[c] prostgi2[c] h2o[c] na1[c] & na1[e] & & na1[e] & & na1[e] & & na1[e] & & na1[e] & & na1[e] & & & na1[e] & & na1[e] & na1[c] & h2o[x] o2[x] coa[x] & nadh[x] nadh[x] o2[x] ttccoa[c] galside_hs[l] & h[l] pi[e] & & h2o2[x] h2o2[x] h[c] hco3[c] digalside_hs[l] cs_b_deg2[l] pi[c] h2o[e] pi[c] h[c] coa[x] & accoa[x] coa[x] cs_a_deg5[l] cs_b_deg3[l] & & so4[l] h[l] h[l] so4[l] h2o[c] hco3[e] ttdca[c] ttdca[e] h2o[x] & o2[x] nad[x] gthrd[c] na1[e] h[c] so4[l] h[l] so4[l] so4[l] h[l] coa[l] coa[c] 3hexdtricoa[x] coa[x] o2[x] h2o2[x] pi[c] na1[e] HC02200[c] HC02201[c] h2o[l] h2o[l] h2o[l] h2o[l] HC02204[c] hco3[e] atp[c] adp[c] 2dodtricoa[x] HC02199[c] & h2o[l] so4[l] acgal[l] acgam[l] h2o[l] acgam[l] acgam[l] wharachd[c] HC02187[c] cl[c] ala_L[e] tyr_L[e] trp_L[e] phe_L[e] ser_L[e] cys_L[e] ile_L[e] thr_L[e] val_L[e] asn_L[e] hom_L[e] gly[e] leu_L[e] gln_L[e] asp_L[e] met_L[e] arg_L[e] & h2o[x] nad[x] nadh[x] hco3[c] h[l] acgam[l] acgam[l] adp[c] & thyox_L[c] bilglcur[c] HC02210[c] HC02208[c] HC02196[c] h2o[c] h[c] amp[x] h[x] & & hexccoa[x] glc_D[l] h2o[l] & HC02195[c] HC02213[c] & CE2038[x] & CE5125[x] CE5126[x] nad[x] nad[x] M00783[x] & M00049[x] & nad[x] pi[c] h[l] gal[l] h2o[l] gal[l] h2o[l] gal[l] h2o[l] gal[l] h2o[l] h[c] & pan4p[c] ptth[c] tchola[c] pi[c] h[c] atp[x] 3ohdcoa[x] h2o2[x] nadh[x] hco3[c] hco3[c] & & & & & h2o[l] M02613[c] M02613[e] h[c] nad[x] accoa[x] accoa[x] & & & & coa[x] & nadph[x] nadp[x] nadh[x] tettet6coa[x] accoa[x] h2o2[x] accoa[x] & & hco3[c] h2o[l] HC02202[c] hco3[e] bildglcur[c] hco3[e] triodthy[c] hco3[e] atp[c] adp[c] o2[x] coa[x] h[x] & h2o[l] & prostge1[c] hco3[c] HC02217[c] hco3[e] HC02206[c] hco3[e] HC02197[c] HC02198[c] & adp[c] h2o[l] HC02194[c] hco3[e] HC02220[c] HC02180[c] hco3[e] HC02214[c] hco3[e] HC02216[c] hco3[e] h2o[c] h2o2[x] ppi[x] h[x] & ddcacoa[x] & dcacoa[x] coa[x] nad[x] o2[x] h2o[x] & & & & malttr[l] gal[l] h2o[l] ksi_deg29[l] & ksi_deg28[l] & ksi_deg27[l] & ksi_deg26[l] & ksi_deg25[l] & ksi_deg24[l] & ksi_deg23[l] & ksi_deg22[l] & ksi_deg21[l] & ksi_deg20[l] & ksi_deg19[l] & ksi_deg18[l] & ksi_deg17[l] & ksi_deg16[l] & ksi_deg15[l] h[c] hco3[e] h2o[c] atp[c] coa[x] h2o2[x] nad[x] atp[c] pi[c] h[c] & & hco3[e] & & atp[c] dca[c] & dca[e] pi[c] h[x] h2o[x] coa[x] 3hdcoa[x] h2o2[x] c226coa[c] & cs_b[l] & cspg_b[l] h2o[l] so4[l] h2o[l] h2o[l] adp[c] & h[x] h2o2[x] h2o[c] o2[x] coa[x] HC02199[e] atp[c] h2o[l] h2o[l] so4[l] h2o[l] h2o[l] so4[l] acgam[l] h2o[l] h2o[l] acgam[l] so4[l] h2o[l] so4[l] gal[l] ppi[c] h[c] atp[c] adp[c] adp[c] h2o2[x] & & h2o[x] hco3[e] HC02201[e] acgam[l] h[l] acgam[l] h[l] h[l] acgam[l] h[l] h2o[l] pi[l] h[x] nadh[x] o2[x] nadh[x] h[x] nadh[x] na1[c] na1[c] glcur[l] so4[l] h[l] atp[c] h2o[c] h2o[c] nad[x] o2[x] h[x] h[x] h2o[x] co2[c] & & hco3[e] hco3[e] malt[l] cs_c_deg1[l] pi[c] h[c] pro_L[c] hdca[c] accoa[x] h2o[x] gthrd[e] h2o[c] so4[l] h[c] cmp[c] HC02199[e] arach[c] & arach[e] & h2o[x] na1[e] cl[e] xyl_D[l] h[l] so4[l] h2o[l] h[l] h[l] & & coa[x] atp[x] 3dodtricoa[x] hexdectecoa[x] coa[x] nadh[x] & HC02200[e] hco3[e] na1[c] h[l] h2o[l] h2o[l] h2o[l] so4[l] so4[l] atp[c] adp[c] hdd2coa[x] & HC01397[x] nadh[x] h[x] nad[x] cl[c] gluside_hs[c] gluside_hs[l] h2o[l] dpcoa[l] dpcoa[c] h2o[c] h[x] CE2250[x] h[l] acgam[l] acgam[l] acgam[l] h[c] na1[e] HC02201[c] pi[c] h[c] ppi[c] nadh[x] CE2246[x] & ppi[c] cys_L[c] cysam[c] na1[c] ppi[x] CE2245[x] coa[x] gchola[c] & h[l] gal[l] hom_L[c] & n2m2nmasn[l] h2o[l] acgam[l] h2o[l] acnam[l] h2o[l] so4[l] h2o[l] gal[l] & h2o[l] gal[l] & h2o[l] & h2o[l] ctp[c] dlnlcg[c] & dlnlcg[e] atp[c] adp[c] h2o2[x] h2o2[x] & nad[x] so4[l] & h[x] h2o[x] h2o[x] h2o[x] h2o[x] 4abut[e] 4abut[l] h2o[l] & prist[c] & prist[x] HC10858[x] & HC10857[x] & HC10856[x] & coa[x] & 4abut[c] & gal[l] gal[l] h2o[l] h2o[l] h[l] coa[x] h2o[x] h[x] & tca3s[c] tchola[e] h2o[l] h[l] glcur[l] & h2o[c] & h2o2[x] h[x] h[l] acgal[l] acgal[l] ksi_deg2[l] & ksi_deg3[l] & ksi_deg4[l] & ksi_deg5[l] & ksi_deg6[l] & ksi_deg7[l] & ksi_deg8[l] & ksi_deg9[l] & ksi_deg10[l] & ksi_deg11[l] & ksi_deg12[l] & ksi_deg13[l] & ksi_deg14[l] M00017[c] M00017[e] h2o2[x] nad[x] nadh[x] & paps[c] & h[c] h2o[l] h2o[l] 4ppcys[c] 4ppan[c] pnto_R[c] pnto_R[e] pi[c] h[c] h2o[x] amp[x] coa[x] accoa[x] accoa[x] coa[x] & adp[c] na1[e] pi[l] & Asn_X_Ser_Thr[l] & & atp[x] h2o[x] h2o[x] h[c] & cs_c_deg5[l] & cs_c_deg4[l] & & cs_c[l] & cspg_c[l] & bilglcur[e] hco3[c] h2o[c] nadph[x] dd2coa[x] & nad[x] o2[x] pap[c] amp[c] cs_c_deg3[l] & cs_c_deg2[l] h2o[l] so4[l] h2o[l] h2o[l] so4[l] h2o[l] acgam[l] h2o[l] so4[l] h2o[l] acgam[l] hco3[c] HC02180[e] atp[c] adp[c] h[x] nadh[x] & & coa[x] accoa[x] atp[c] & h[e] h[c] amp[l] & adn[l] h[l] acgam[l] prostgi2[e] hco3[c] HC02216[e] hco3[c] bildglcur[e] hco3[c] triodthy[e] hco3[c] pi[c] h[c] coa[x] gly[c] & h[l] h[l] na1[c] hco3[c] HC02198[e] hco3[c] HC02197[e] nad[x] accoa[x] atp[c] o2[x] & hco3[c] pap[c] h[e] h[c] h2o[l] h[l] ppi[c] atp[c] na1[e] hco3[c] prostge1[e] hco3[c] HC02195[e] atp[c] adp[c] & h[x] arachcoa[x] c226coa[x] & clpndcoa[x] na1[c] coa[c] glcur[l] h[l] so4[l] h2o[l] h2o[l] HC02208[e] HC02217[e] & h[x] h2o[x] h[x] h2o2[x] & & acgal[l] h2o[l] fuc_L[l] ksi[e] adp[c] HC02214[e] wharachd[e] hdcea[c] hdcea[e] pro_L[e] ile_L[e] gly[e] trp_L[e] val_L[e] thr_L[e] lys_L[e] arg_L[e] his_L[e] ile_L[e] cys_L[e] phe_L[e] ser_L[e] asn_L[e] leu_L[e] tyr_L[e] gln_L[e] met_L[e] ala_L[e] pristanal[c] pristanal[x] & o2[x] nad[x] docoscoa[x] & & & & cys_L[c] h[c] & HC02213[e] HC02187[e] thyox_L[e] HC02220[e] h[x] & CE2242[x] accoa[x] clpndcoa[c] adp[c] so4[l] h2o[l] atp[c] & nad[x] nadh[x] h[x] paps[c] h2o[c] adn[e] & adn[c] n2m2nm[l] adp[c] atp[c] hco3[c] HC02206[e] HC02210[e] HC02196[e] HC02194[e] nadh[x] coa[x] nad[x] h2o[x] CE2249[x] & CE2253[x] h2o[x] h[c] hco3[e] h[c] so4[l] so4[l] cs_d_deg1[l] HC02204[e] h2o[c] M01235[c] M01235[e] nad[x] o2[x] 3hddcoa[x] & 3oddcoa[x] nadh[x] h[x] h2o[l] h[l] h[c] pi[c] na1[e] & pi[c] h[c] h[x] pi[c] h[l] ksi_deg1[l] & ksi[l] amp[c] tchola[e] h2o[c] na1[e] na1[e] na1[e] na1[c] na1[c] na1[e] na1[e] na1[e] na1[e] na1[e] nadh[x] h2o[x] M01191[x] & M03019[x] h2o2[x] nadh[x] coa[c] atp[c] galgluside_hs[l] h2o[l] & h2o[l] Ser_Gly_Ala_X_Gly[l] & h2o[c] & & & & & & & & & & & & & & & & h[x] nad[x] nadh[x] o2[x] pi[c] taur[c] acgal[l] h[c] & & & & & & & atp[c] adp[c] pi[c] h[c] tchola[c] galgluside_hs[c] acnam[l] h[l] h[c] na1[c] HC02202[e] & & & & & & & & nad[x] h[x] h2o[x] coa[x] h[c] h2o[c] & h2o[l] & & & nadh[x] h2o[x] & h2o2[x] h2o2[x] & gca3s[c] & so4[l] acgam[l] h2o[l] & & hco3[c] atp[c] adp[c] & & gm3_hs[l] & h2o[l] s2l2n2m2masn[e] & & & o2[x] & h2o[x] & gal[l] h2o[l] h2o[l] & lgnc[c] & lgnc[e] & & & & & & o2[x] nad[x] cholcoa[c] h2o[l] h[l] h2o[l] h2o[l] h[l] acgam[l] Asn_X_Ser_Thr[l] & & hco3[c] & na1[c] na1[c] na1[c] na1[e] na1[e] na1[c] na1[c] na1[c] na1[c] na1[c] thcrm_hs[l] glcur[l] gal[l] acnam[l] formcoa[c] formcoa[x] 4hexdtricoa[x] & 2octdectecoa[x] 3octdectecoa[x] & eipencoa[x] & coa[x] o2[x] hco3[e] acgal[l] so4[l] acgam[l] adp[c] atp[c] hco3[e] M01207[c] M01207[e] 5tedtricoa[x] h[x] nadh[x] thcrm_hs[c] acnam[l] h2o[c] nad[x] & & accoa[x] acgal[l] h[c] hco3[e] h2o[c] accoa[x] tetpent3coa[x] atp[c] cs_d_deg6[l] & cs_d_deg5[l] & cs_d_deg4[l] & cs_d_deg3[l] & cs_d_deg2[l] & cs_d[l] & cspg_d[l] & s2l2n2m2masn[l] & s2l2fn2m2masn[l] s2l2fn2m2masn[e] pi[c] h[c] M00885[x] & M01573[x] & M03022[x] tetpent3coa[c] h[c] h2o[c] h2o[l] n2m2nmn[l] & m2mn[l] & n2m2mn[l] & l2n2m2mn[l] & s2l2n2m2mn[l] & s2l2n2m2m[l] pi[c] h2o[c] pi[c] h[c] pro_L[c] ile_L[c] gly[c] trp_L[c] val_L[c] thr_L[c] lys_L[c] arg_L[c] his_L[c] ile_L[c] cys_L[c] phe_L[c] ser_L[c] asn_L[c] leu_L[c] tyr_L[c] gln_L[c] met_L[c] ala_L[c] o2[x] adp[c] atp[c] na1[c] na1[e] HC02187[c] h2o[x] nadh[x] pi[c] ca3s[c] coa[c] h[l] h2o[l] HC02210[c] HC02217[c] wharachd[c] thyox_L[c] HC02220[c] HC02196[c] atp[c] adp[c] atp[c] adp[c] h[x] coa[x] nadh[x] h2o2[x] M00172[x] nad[x] acgal[l] so4[l] h2o[l] HC02202[c] HC02206[c] HC02213[c] HC02214[c] HC02194[c] nad[x] h2o2[x] h2o[c] h2o[c] udpacgal[c] udpacgal[l] acgal[l] M02013[l] & glu_L[l] h2o[l] glu_L[l] h2o[l] h2o[x] h2o[x] h2o[x] h[c] Bile acid & so4[l] acgal[l] h2o[l] h2o[l] h2o[l] glu_L[l] h2o[l] tchola[c] phyt[c] phyt[x] h2o2[x] h2o[x] & & & & h2o[l] h2o[l] h2o[l] hco3[e] hco3[e] hco3[e] & & nadh[x] h2o[x] coa[x] h2o[l] h2o[l] fuc_L[l] HC02204[c] hco3[e] hco3[e] prostge1[c] hco3[e] prostgi2[c] hco3[e] HC02216[c] hco3[e] bilglcur[c] HC02180[c] bildglcur[c] triodthy[c] hco3[e] HC02198[c] hco3[e] HC02197[c] hco3[e] HC02195[c] lnlnca[c] lnlnca[e] M02457[c] M02457[e] nadp[x] hco3[e] hco3[c] h2o[l] h2o[l] h[l] acgam[l] thf[l] & 5thf[l] & 6thf[l] & 7thf[l] HC02208[c] coa[x] nad[x] & coa[x] hco3[e] tdechola[e] & h[l] h2o[l] h[x] & hco3[c] adp[c] & & glu_L[l] cmpacna[c] h2o[c] accoa[x] & M03047[x] M03047[c] nadp[c] acgal[c] h2o[l] cs_e_deg2[l] & cs_e_deg1[l] h2o[l] glu_L[l] h2o[l] glu_L[l] h2o[l] h2o[c] atp[x] CE2243[x] & CE2247[x] ppcoa[x] & pi[c] so4[l] h2o[l] h2o[l] acgam[l] 13_cis_retn[e] pi[c] h[c] pi[c] h[c] & & & 3dhchol[c] hco3[c] & acgal[l] gd1a_hs[c] & accoa[x] o2[x] & coa[x] h2o[x] 3dhchol[e] h2o[c] gm2_hs[l] h2o[l] cs_e_deg5[l] h[l] h2o[l] h2o[l] dhf[l] & 5dhf[l] & 6dhf[l] & 7dhf[l] atp[c] adp[c] coa[x] coa[x] o2[x] accoa[x] nad[x] h[x] o2[x] HC02200[e] HC02200[c] adp[c] h[c] h[l] so4[l] & h2o[l] h[l] atp[c] adp[c] nad[x] h[x] & na1[c] hco3[c] ga2_hs[l] so4[l] h2o[l] HC02201[e] hom_L[e] coa[x] & phyt2ohcoa[x] h2o2[x] h2o2[x] na1[e] udp[l] & mn[l] & man[l] h[l] hdca[l] dlnlcg[l] lnlnca[l] h[x] nad[x] nadh[x] nad[x] hco3[e] hco3[c] h[c] & gm3_hs[l] & & & & nadh[x] & pi[c] M02012[l] so4[l] nadh[x] o2[x] h2o2[x] nadph[c] & chsterol[l] & lnlncg[c] & lnlncg[e] M02053[c] M02053[e] h2o[x] h2o2[x] h[x] nadh[x] hco3[e] & & gm2_hs[l] so4[l] & HC00822[l] xolest182_hs[l] & xolest205_hs[l] asn_L[e] nadp[x] h2o2[x] & so4[l] & h2o[l] man[l] h2o[c] o2[x] h[x] o2[x] coa[x] nadh[x] nad[x] accoa[x] M01141[x] & M00849[x] accoa[x] coa[x] o2[c] gca3s[e] gal[l] h2o[l] acgal[l] so4[l] h2o[l] Ser_Gly_Ala_X_Gly[l] & nadph[x] nad[x] o2[x] accoa[x] accoa[c] na1[c] na1[e] HC02193[e] acgal[l] h2o[l] pi[c] h[c] h2o[x] & atp[c] HC02192[e] h[l] h2o[l] h2o[l] arachd[l] strdnc[l] hdcea[l] h2o[c] co2[x] CE5155[x] CE5154[x] h2o[x] M01989[e] HC02191[e] gal[l] h2o[l] tmndnc[l] pi[c] h[c] atp[c] adp[c] amp[x]ppi[x] 2hexdtetcoa[x] 3hexdtetcoa[x] & hexdpencoa[x] & 4hexdtetcoa[x] & strdnccoa[x] eitetcoa[x] & 2docopencoa[x] & h[x] h[x] & pap[c] cs_e_deg4[l] & cs_e_deg3[l] & cs_e[l] lnlc[l] h[l] h2o2[x] h[c] h[c] gd1b_hs[l] & cs_e_deg7[l] & cs_e_deg6[l] h[l] & cspg_e[l] & h[l] cmpacna[n] & acnam[n] acnam[c] acnam[e] coa[x] stcoa[x] & CE2251[x] & h[x] adp[c] h2o[c] atp[c] adp[c] tethex3coa[x] nadh[x] atp[c] & acgal[l] h[l] ppi[n] ctp[n] h[x] h2o[x] tdechola[c] h2o[l] & docosac[c] & docosac[e] hdd2coa[c] coa[x] tdca3s[c] & glcur[l] h2o[l] & glcur[l] h2o[l] lnlncg[l] crvnc[l] 13_cis_retn[c] accoa[x] cholate[c] & cholate[e] hco3[c] hco3[c] gbside_hs[e] gbside_hs[c] gbside_hs[l] xolest183_hs[l] itp[n] elaid[c] & elaid[e] h2o[c] na1[e] gly[c] phe_L[c] tyr_L[c] leu_L[c] hom_L[c] val_L[c] ile_L[c] ile_L[c] thr_L[c] gln_L[c] met_L[c] pro_L[c] trp_L[c] ala_L[c] his_L[c] arg_L[e] cl[e] h2o[x] coa[x] dd3coa[x] h2o2[x] o2[x] h[c] hco3[c] na1[e] hco3[c] h[l] acgal[l] itp[c] nadh[x] accoa[x] nad[x] coa[x] h2o[x] h[c] h[c] paps[c] coa[c] hco3[c] hco3[c] hco3[c] hco3[c] & h2o[l] h[l] h2o[l] pi[c] h[c] phytcoa[c] phytcoa[x] h[x] & h2o[x] & ac[x] ac[c] h2o[c] & h2o[l] biocyt[n] 1a25dhvitd3[n] succ[x] o2[x] nad[x] coa[x] pi[c] h[c] hco3[c] hco3[c] hco3[c] so4[l] coa[c] & h2o[c] h[c] pi[c] nad[x] udpglcur[c] HC02201[c] udpacgal[l] gal[l] adp[n] atp[c] adp[c] & & & 3docopencoa[x] h2o[x] & HC02199[c] HC02201[c] hco3[c] glcur[l] gm1_hs[n] pi[c] h[c] h[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[e] adp[c] accoa[x] & tetde5coa[x] & hexde7coa[x] accoa[x] & nadh[x] adp[c] h2o[c] HC02200[c] na1[e] acgam[l] xolest226_hs[l] h2o[n] & & & & & & & & o2[x] coa[x] & HC02200[c] h[l] h2o[l] h2o[l] h2o[l] h2o[l] 13_cis_oretn[c] h2o[n] h2o[c] coa[x] adp[c] udp[c] gthrd[c] HC02199[c] HC02200[c] gm1_hs[l] & & atp[c] adp[c] h[x] h2o2[x] h[c] hco3[e] atp[c] & na1[e] HC02199[c] & hs_deg24[l] hs_deg22[l] h[l] hs_deg20[l] hs_deg18[l] hs_deg16[l] hs_deg14[l] hs_deg12[l] hs_deg10[l] hs_deg8[l] hs_deg6[l] hs_deg4[l] hs_deg2[l] doco13ac[c] & doco13ac[e] nadp[x] nadh[x] nadh[x] o2[x] nadh[x] adp[c] atp[c] paps[c] hco3[c] HC02201[c] udpacgal[l] so4[l] h2o[l] h2o[l] & coa[x] CE4855[x] ca24g[c] pi[c] & gthrd[c] h2o[l] gal[l] so4[l] h2o[l] h2o[l] h2o[l] so4[l] h2o[l] h2o[l] so4[l] h[l] gd1a_hs[n] gd1a_hs[n] gd1a_hs[c] & & & & & c4dc[x] h[x] o2[x] od2coa[x] & CE2248[x] & 3ohodcoa[x] pap[c] h[c] paps[c] & & gthrd[c] so4[l] 13_cis_retn[n] atp[n] h2o[c] CE4855[c] & & & gd2_hs[l] lys_L[n] lnlc[c] & lnlc[e] pi[c] h[c] h[e] na1[e] na1[e] na1[e] & na1[e] & na1[e] & & & na1[e] & & na1[e] & & na1[e] & na1[c] h2o2[x] h2o[x] h[x] & pi[c] HC02201[e] HC02201[c] & pi[c] & & h[l] h[l] h[l] coa[n] accoa[x] nad[x] h2o[c] taur[c] & & & & & & h[l] retn[c] idp[n] atp[c] adpac[x] accoa[x] h[x] & pap[c] h[c] & & & & h[l] h[l] & so4[l] & atp[c] adp[c] pi[c] h2o[x] h2o2[x] h2o[c] h2o[x] & dchac[e] ga1_hs[l] acgam[l] so4[l] & h[l] & & & & h[l] so4[l] & & & & h[l] h2o[c] h[x] & CE5156[x] coa[x] na1[c] HC02200[e] acgagbside_hs[l] h2o[l] & & & h2o[l] h2o[l] h2o[l] btn[n] coa[x] M01989[c] pi[c] & HC02201[e] HC02199[e] gthrd[e] & & & so4[l] so4[l] & & 13_cis_oretn[n] pi[c] h[c] coa[x] nadph[x] h2o2[x] tethex3coa[c] gdca3s[e] & gdca3s[c] & hco3[e] hco3[c] h2o[c] & & h[l] & & na1[c] gly[e] phe_L[e] tyr_L[e] leu_L[e] hom_L[e] val_L[e] ile_L[e] ile_L[e] thr_L[e] gln_L[e] met_L[e] pro_L[e] trp_L[e] ala_L[e] his_L[e] arg_L[c] cl[c] & h[x] & h[c] & CE1589[c] HC02199[e] & glcur[l] & cholp[c] h[x] crn[x] nad[x] coa[x] atp[c] atp[c] HC02200[e] gthrd[e] HC02199[e] udp[l] h2o[l] & hretn[c] atp[c] adp[c] M01582[c] M01582[e] akg[c] nadh[x] nad[x] na1[c] HC02201[e] acgam[l] h[l] hs_deg1[l] & hs[l] & hspg[l] nadh[x] h[x] hco3[c] ppi[c] HC02201[e] hco3[e] hco3[e] HC02200[e] h2o[l] acgam[l] so4[l] idour[l] h[l] acgam[l] h[l] retn[n] udpgal[c] h2o[c] & stcoa[c] gthrd[c] gthrd[e] & ca3s[c] HC02199[e] HC02199[c] gthrd[e] na1[c] idour[l] idour[l] & coa[x] & h[x] hco3[e] ca3s[e] hco3[e] amp[c] hco3[e] hco3[e] pi[c] h[c] o2[x] h2o[x] ppi[x] & pi[x] docohexcoa[x] o2[x] CE5153[x] & CE5152[x] & CE5151[x] hco3[e] hco3[c] hco3[e] h[l] ocdcea[l] hs_deg25[l] hs_deg23[l] hs_deg21[l] h2o[l] hs_deg17[l] hs_deg15[l] h2o[l] hs_deg11[l] hs_deg7[l] h2o[l] hs_deg5[l] hs_deg3[l] so4[l] crm_hs[c] strdnc[c] & strdnc[e] o2[x] h[x] h2o[c] & hco3[e] hco3[e] hco3[e] hco3[e] h2o[l] hs_deg19[l] h2o[l] hs_deg13[l] hs_deg9[l] h2o[l] h2o[x] nadh[x] nad[x] accoa[x] h2o[x] hco3[c] & udp[l] gd3_hs[l] h2o[l] h[l] Ser_Gly_Ala_X_Gly[l] atp[c] adp[c] icit[x] & h2o[x] hco3[c] hco3[e] & adp[c] & hco3[e] hco3[e] hretn[n] dag_hs[c] icit[c] akg[x] ocde9ecoa[x] coa[c] h[c] h2o[c] atp[c] pi[l] h2o[c] 3hadpac[x] & 3hadicoa[x] & adpcoa[x] h2o2[x] h[x] docoscoa[c] hco3[c] gbside_hs[c] glu_L[l] h2o[l] pi[l] h2o[l] h2o[l] h2o[l] pi[l] & & nadh[x] o2[x] adp[c] atp[c] hco3[e] coa[c] hco3[e] glu_L[l] h2o[l] cmp[l] pi[c] h[c] nadp[x] nadh[x] succoa[x] & deoxfvs[x] & amp[c] h2o[l] cytd[l] & h2o2[l] h2o[l] M03045[c] M03045[e] nadp[c] nadp[x] co2[x] nadph[x] fvs[x] h2o2[x] & h[c] & nadp[c] o2[c] h2o[c] h[c] h[c] amp[c] hestratriol[l] & CE5253[l] accoa[x] HC02196[e] gly[c] h2o[c] nadph[c] taur[c] acgbgbside_hs[l] h[l] gsn[l] & gmp[l] ump[l] & galside_hs[c] atp[c] adp[c] & co2[x] h[x] h2o[x] h2o[x] nadh[x] & HC02196[c] & o2[c] ppi[c] ppi[c] 10fthf[l] & 10fthf5glu[l] & 10fthf6glu[l] & 10fthf7glu[l] thymd[l] & dtmp[l] uri[l] asn_L[c] h2o2[x] coa[x] accoa[x] h2o[x] cholate[x] h2o[c] hco3[c] hco3[e] gthrd[e] gthrd[c] h[c] atp[c] h2o[l] pi[l] h2o[l] h[l] meoh[l] & fald[l] amp[n] h2o[c] co2[e] co2[c] & o2[x] adp[c] pi[c] h2o[c] h2o2[l] amp[c] & accoa[x] nad[x] coa[x] h2o2[x] nadh[x] h[x] & h2o[x] fadh2[x] fad[x] CE5166[x] o2[x] h2o[x] atp[x] pi[c] gly[c] h[c] pi[c] h[c] h[x] nad[x] & dchac[c] & & HC02192[c] mi1p_D[c] ocdcea[c] & ocdcea[e] tchola[x] & h[c] atp[c] h[c] HC02191[c] atp[c] h[x] coa[x] crn[x] h2o2[x] h2o2[x] h[x] coa[x] h2o2[x] tchola[e] nadph[c] glu_L[l] atp[c] adp[c] val_L[c] HC01434[x] o2[x] & pi[x] adp[x] h[x] & & coa[x] & nadph[c] & HC02193[c] pchol_hs[c] h2o[c] o2[x] CE5144[x] & CE5148[x] & CE5150[x] cholcoas[x] & pi[c] gudca3s[e] & gudca3s[c] na1[c] na1[e] & o2[c] pi[c] h[c] nadph[c] nadph[x] c14dccoa[x] & hexdicoa[x] dcsptn1coa[x] h2o[x] nad[x] h[x] nadp[c] nadp[c] so4[c] pa_hs[n] c6dc[x] & & nadp[c] h[c] hexc[c] & hexc[e] h[x] h2o2[x] & M02155[e] atp[c] adp[c] coa[x] atp[c] h[c] paps[c] o2[x] leuktrB4wcooh[x] & CE5947[x] nad[x] h[x] & HC02191[x] & h[c] h[c] hco3[e] hco3[c] h[c] udpglcur[c] nadph[c] paps[c] accoa[x] nadh[x] nad[x] coa[x] o2[x] o2[x] h2o[x] HC02192[x] h2o[c] adp[c] h2o[c] paps[c] dca24g[c] & ditp[n] ditp[c] h2o[c] h[x] nad[x] pi[c] amp[c] gthrd[c] h2o[c] & pi[c] h[c] o2[x] ei11ecoa[x] atp[c] 7klitchol[e] urscholcoa[c] gthrd[e] 3dhdchol[c] & & h2o[c] & & hdca[c] & hdca[e] coa[x] coa[x] h[x] CE5157[x] & h[x] & adp[n] atp[n] adp[n] h[n] adp[n] h2o[x] nadph[x] & atp[x] cdca24g[e] & & h[c] & & oretn[c] oretn[n] atp[c] adp[c] subeac[x] & nadp[x] & h2o2[x] o2[x] tdchola[c] cdca24g[c] pap[c] pi[c] & o2[c] h[c] & trp_L[e] ala_L[e] pro_L[e] tyr_L[e] leu_L[e] ser_L[e] asn_L[e] ile_L[e] thr_L[e] gly[e] hom_L[e] cys_L[e] phe_L[e] gln_L[e] met_L[e] his_L[e] arg_L[e] cl[c] & h2o[x] & amp[x] cdca3g[e] & cdca3g[c] ppi[c] paps[c] udp[c] pap[c] & accoa[x] h2o2[x] h[x] tdchola[x] h[x] adp[x] na1[e] h2o[c] galside_hs[n] h2o[c] succ[c] nadh[x] h2o[x] coa[x] h2o[x] ppi[x] pi[x] adp[c] coa[c] atp[c] adp[c] h[c] h[c] pi[c] h[c] & nad[x] M02155[c] & hdca24g[c] & & udp[c] pap[c] & ca24g[e] & M03153[c] M03153[e] coa[x] h2o2[x] & tdchola[e] hco3[c] taur[c] & HC02195[c] & HC02195[e] h2o[c] h[c] dgtp[n] & dgdp[n] h[n] atp[c] adp[c] na1[e] & & na1[e] & & na1[e] & & na1[e] & & na1[e] & & & na1[e] & & na1[e] & & & na1[e] & & na1[c] & na1[c] h[x] accoa[x] o2[x] h2o[x] coa[x] h[c] pap[c] h[c] h[c] c4dc[c] h2o[x] h2o[x] adp[c] h[c] h2o[c] pi[c] pi[c] adp[c] h[c] nadph[c] h[c] tmndnc[c] h[c] h[n] accoa[x] CE5158[x] atp[x] & & h[c] atp[c] udpglcur[c] HC02197[c] atp[n] h2o[c] nadh[x] & nadph[x] & & atp[n] pi[c] h[c] h2o[x] nadh[x] amp[x] hco3[e] & nadph[c] na1[c] atp[c] udp[c] udp[c] HC02198[e] hco3[e] 5dhf[c] & didp[n] didp[c] xoldiolone[c] & xoldiolone[e] h2o[x] odecoa[x] cholcoar[x] & cholcoads[x] & cholcoaone[x] & cholcoa[x] hyochol[e] udpglcur[c] atp[c] & udpglcur[c] HC02198[c] & arachd[c] strdnc[c] 6dhf[c] hdcea[c] 7dhf[c] thf[c] hdca[c] 5thf[c] dlnlcg[c] 6thf[c] lnlnca[c] pail35p_hs[n] & crn[x] h2o[x] coa[x] udp[c] coa[c] udp[c] h2o[c] pi[c] dhf[c] 7thf[c] pail3p_hs[n] atp[c] adp[c] & na1[c] na1[c] na1[c] na1[c] & na1[c] & & na1[c] & na1[c] & & na1[e] & & na1[e] & adpac[e] adpac[c] nad[x] h[x] coa[x] na1[e] h2o[c] dca3s[e] & dca3s[c] lca3s[c] nadp[c] & h[c] acnam[c] h[n] udp[n] na1[c] nadh[x] o2[x] accoa[x] h[x] nadp[c] hco3[c] gthrd[c] na1[e] adp[c] h2o[c] xolest226_hs[c] o2[c] o2[n] h2o[c] o2[x] h2o2[x] nad[x] h2o2[x] nadp[x] dcholcoa[x] & dgchol[x] na1[c] & hco3[e] na1[e] crvnc[c] & o2[x] nadh[x] crn[x] h2o[x] coa[x] & h[c] dca3g[c] h2o[c] gthrd[e] coa[c] man[c] lnlncg[c] chsterol[c] xolest205_hs[c] h[c] adp[n] atp[n] pi[n] atp[n] pi[c] h[c] c8dc[x] & sbcoa[x] & sebcoa[x] & c12dccoa[x] & dodecanac[x] nadh[x] dgchol[c] h[c] & & C02528[c] & 7klitchol[c] & HC02194[c] & paps[c] pap[c] & na1[c] coa[c] accoa[c] gsn[c] gmp[c] ump[c] uri[c] accoa[c] fuc_L[c] lnlc[c] xolest183_hs[c] nh4[n] nh4[c] eicostet[c] & eicostet[e] ppi[x] ppcoa[x] taur[x] HC02194[e] atp[c] 3dhlchol[c] adp[c] & cmp[c] glcur[c] crvnc[e] trp_L[c] ala_L[c] pro_L[c] tyr_L[c] leu_L[c] ile_L[c] thr_L[c] gly[c] hom_L[c] cys_L[c] phe_L[c] gln_L[c] met_L[c] his_L[c] arg_L[c] cl[e] 3hadpac[e] 3hadpac[c] doco13ecoa[x] coa[x] nad[x] & coa[x] coa[x] M00743[x] o2[c] hco3[c] hco3[e] h[c] atp[c] coa[c] coa[c] accoa[c] cytd[c] pi[c] na1[c] atp[c] adp[c] ser_L[c] asn_L[c] lca24g[c] lca3g[c] atp[c] gd1b_hs[c] accoa[c] idour[c] h2o[c] dudp[c] h[x] crn[x] h2o2[x] h2o[x] nadh[x] h[x] h[c] & gthrd[e] hco3[e] & gd3_hs[c] h2o2[c] meoh[c] acgam[c] & udp[c] pchol_hs[n] h2o[c] h2o[x] coa[x] coa[x] h[x] accoa[x] h[x] h[x] ppcoa[x] & h[c] pi[c] pi[c] nadp[c] o2[c] h[c] acgbgbside_hs[c] fald[c] & udpgal[n] nad[x] crn[x] h2o2[x] accoa[x] nadh[x] gly[x] adp[c] h2o[c] tudca3s[c] h2o[c] gthrd[e] & acgagbside_hs[c] gm1_hs[c] 10fthf[c] 10fthf5glu[c] na1[c] adp[n] pi[c] h[c] atp[x] & & h2o[c] nadp[c] & & atp[c] udp[c] adp[c] hco3[c] 10fthf6glu[c] & xol7aone[c] & xol7aone[e] coa[x] & & accoa[x] atp[c] na1[c] nadph[c] h[c] h[c] nadph[c] & dca3g[e] h2o[c] pi[c] gthrd[c] 10fthf7glu[c] xolest182_hs[c] atp[c] & c6dc[c] o2[x] & & gthrd[c] CE5253[c] xyl_D[c] thymd[c] dtmp[c] h[c] h[c] s2l2n2m2m[c] & crm_hs[n] dag_hs[n] atp[c] adp[c] h2o2[x] h2o2[x] h[x] 3hpvscoa[x] 3hpvstetcoa[x] h2o[x] M00743[c] hca24g[e] & hca24g[c] & hyochol[c] & hdca6g[c] hestratriol[c] h[e] trdrd[c] trdrd[n] h2o[n] sph1p[n] & sphgn[n] sphgn[c] accoa[x] & & h2o[x] & dgcholcoa[x] pi[c] h[c] hco3[e] ocdcea[c] & h2o[x] coa[x] o2[x] nad[x] & & atp[c] glu_L[c] & h[n] cholp[n] h2o[c] & & h[x] atp[c] nadp[c] h2o[c] na1[c] pi[c] atp[c] lca24g[e] & hco3[c] & pi[c] na1[e] h[n] pi[c] h[c] o2[x] & coa[x] HC01459[x] gly[x] ppcoa[x] h2o[c] na1[e] h2o[c] atp[c] atp[c] hdcea[e] o2[n] h[n] pi[n] adp[n] atp[n] tmndnc[c] & tmndnc[e] coa[x] h2o[x] coa[x] h2o[x] & nad[x] o2[x] o2[x] fad[x] hca6g[c] & h[c] HC02197[e] na1[c] acnam[e] h2o2[n] h2o[n] h[n] atp[c] adp[c] subeac[c] & thcholstoic[x] & fadh2[x] paps[c] h2o[c] h[c] adp[c] h2o[c] & pi[c] c12dc[x] h2o[x] h2o[c] hco3[e] adp[c] & & h[e] & h2o2[x] c10dc[x] thcholoylcoa[x] udp[c] udp[c] hco3[c] pi[c] h[c] pail345p_hs[n] & h2o[c] val_L[e] dodecanac[c] coa[x] h2o[x] adp[c] hco3[c] pi[c] h2o[c] hdca24g[e] hdca[e] pail34p_hs[n] pi[c] h[c] h2o2[x] & 3dhcdchol[c] & 3dhcdchol[e] pi[c] na1[e] h[n] adp[n] & xol7ah3[c] & xol7ah3[e] co2[x] o2[x] udpglcur[c] atp[c] h[c] h2o[n] h2o2[x] o2[x] h[x] & h[c] pap[c] na1[e] h[e] gsn[e] & h[n] sphs1p[n] atp[c] adp[c] tyr_L[c] c8dc[c] h[x] o2[x] coa[x] & coa[x] & & pi[c] adp[c] adp[c] h[n] & sphings[n] sphings[c] h[x] 3ohsebcoa[x] h2o[x] h[c] hestratriol[e] idour[e] glcur[e] adp[c] atp[n] h[x] & pi[c] adp[n] h[n] sphmyln_hs[n] h2o[c] sebacid[x] nad[x] & nadph[x] h2o[c] atp[c] lca3s[e] lca3g[e] h[c] hdca6g[e] ocdcea[e] accoa[n] h2o[n] h2o[n] pi[c] h[c] h2o[x] atp[c] nrvnccoa[c] nrvnccoa[x] h2o[x] h[c] hca6g[e] h2o[c] h[c] adp[c] udca3s[c] adp[c] o2s[n] adp[n] adp[n] atp[n] clpnd[c] & clpnd[e] h2o[x] h2o[x] coa[x] o2[x] coa[x] o2[x] cytd[e] xolest226_hs[e] crvnc[e] adp[n] 3ohsubac[e] 3ohsubcoa[x] h2o[x] xolest182_hs[e] xolest183_hs[e] xolest205_hs[e] crvnc[c] atp[c] adp[c] 3ohsubac[c] 3ohsubac[x] & nad[x] s2l2n2m2m[e] h[n] & dhcholoylcoa[x] chol[n] & & h2o[c] dhcholestancoa[x] & h2o[x] na1[e] h2o[x] & accoa[x] glyc3p[x] & dhap[x] pi[c] h[c] coa[x] h[c] M00715[x] & M03016[x] wharachd[c] & wharachd[e] h2o[c] nadp[x] & pi[c] pi[c] M00615[x] & atp[c] adp[c] h[x] h2o2[x] amp[x] & & gln_L[e] cl[c] ala_L[e] met_L[e] phe_L[e] asn_L[e] leu_L[e] thr_L[e] ile_L[e] cys_L[e] gly[e] pro_L[e] hom_L[e] trp_L[e] ser_L[e] val_L[e] arg_L[e] gly[e] coa[x] atp[c] ppi[x] & h2o[c] adp[c] & pi[c] h[c] c12dc[c] h2o[c] coa[x] & pi[n] tetpent3[c] & tetpent3[e] & adp[c] & 3ohsebac[x] h[c] & pi[n] atp[c] adp[c] o2[x] atp[n] h2o[n] utp[n] udp[n] na1[c] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] coa[x] & coa[n] pi[n] & & & & & & & & & & & & & & & & & nad[x] nadh[x] glcn[e] abt[e] arab_L[e] abt_D[e] atp[n] h2o[c] na1[x] atp[x] ach[n] h[n] pi[c] h[c] pi[c] & h[x] M02112[x] coa[x] & udca3s[c] & udca3s[e] M00879[x] na1[c] & & adp[c] h[e] xol24oh[e] pail4p_hs[n] & mi14p[n] gtp[n] gdp[n] atp[c] adp[c] h[c] nadh[x] gchola[x] & pail45p_hs[n] & na1[e] & & na1[c] na1[c] & na1[c] & & na1[c] & & na1[c] & na1[c] & na1[c] & na1[c] & & dhcholestanate[x] & hco3[e] hco3[c] h[c] & pi[c] atp[c] atp[n] h[n] h2o[n] tethex3[c] & tethex3[e] c10dc[c] h[n] atp[n] dgtp[n] dgdp[n] h2o[c] adp[n] h[n] gln_L[c] cl[e] ala_L[c] met_L[c] phe_L[c] asn_L[c] leu_L[c] thr_L[c] ile_L[c] cys_L[c] gly[c] pro_L[c] hom_L[c] trp_L[c] ser_L[c] val_L[c] arg_L[c] gly[c] sebacid[c] & lca24g[c] pi[c] h[c] h2o[c] cl[c] HC02200[c] arachd[c] arachd[n] cmp[n] & h2o[n] adp[n] h2o[n] & cdp[n] & ctp[n] ctp[c] atp[c] adp[c] pi[c] h[c] adp[c] oh1[e] nadph[c] cl[e] & o2[n] atp[n] adp[n] atp[c] adp[c] nadp[c] adp[n] & crn[c] coa[c] & & uchol[c] & uchol[e] o2[c] h[c] nadph[c] nadph[c] & & nadp[c] nadp[c] nadh[c] nadp[c] nadp[c] nadp[c] omhdecacid[c] Tetrahydrobiopterin HC01361[e] adp[n] M00010[c] M00010[e] na1[c] h2o[c] nadph[c] nad[c] nadph[c] nadph[c] oh1[c] 15HPET[n] dag_hs[n] amp[c] whhdca[c] & hexdiac[c] hexdiac[e] ctp[n] cdp[n] atp[n] h2o[c] 3ohsebac[c] tettet6coa[c] pmtcrn[c] taur[c] h[c] c81coa[c] & c81crn[c] c81crn[e] whhdca[e] xol27oh[c] & chsterol[c] & xol24oh[c] & xoltri24[c] & M00978[c] & M00976[c] & M01081[c] & M01077[c] coa[c] nadph[c] & sebcoa[c] pi[c] h[c] h2o[c] glc_D[c] glcn[c] nadp[c]nadph[c] nadp[c] nad[c] h[c] pi[c] nmn[c] nmn[n] atp[n] & & & dodecanac[e] 3hpvstetcoa[c] pmtcoa[c] h[c] h[c] atp[c] adp[c] pi[c] h[c] tyr_L[e] h2o[c] h2o[c] o2[c] o2[c] o2[c] h[c] h[c] M00742[c] & M00743[c] nad[c] nadh[c] for[c] h2o[c] thbpt[e] atp[c] atp[c] adrncoa[c] 5mthf[c] atp[n] datp[n] dadp[n] h2o[c] h2o[c] nadph[c] h[c] h2o[c] M00979[c] & M00977[c] & M01082[c] h2o[c] h[c] HC02216[e] hco3[c] prostgi2[e] hco3[c] HC02187[e] hco3[c] triodthy[e] hco3[c] HC02180[e] hco3[c] thyox_L[e] h[n] atp[c] adp[c] abt[c] & arab_L[c] abt_D[c] h[c] atp[c] h2o[c] h2o[c] adp[c] h[c] HC02213[e] hco3[c] cytd[n] cytd[c] CE5947[c] hexccoa[c] atp[c] xylu_L[e] h[c] h[c] crn[c] coa[c] phytcoa[c] h2o[c] crn[c] hco3[c] hco3[c] HC02198[e] atp[n] & txb2[c] & txb2[e] leu_L[e] doco13ecoa[c] glyc3p[c] & nadph[c] o2[c] h2o[c] HC02194[e] gtp[c] & ahdt[c] & HC01361[c] mlthf[c] & pi[n] pi[n] & dcsptn1coa[c] arachcoa[c] h[c] h[c] chsterol[e] lpchol_hs[e] amp[c] hco3[c] HC02202[e] hco3[c] HC02210[e] hco3[c] dhbpt[e] crn[c] itp[c] h[c] h[c] ppi[c] atp[c] HC02206[e] HC02208[e] HC02214[e] HC02217[e] bildglcur[e] wharachd[e] bilglcur[e] HC02220[e] dctp[n] dcdp[n] h2o[c] M00341[c] M00341[e] odecoa[c] pi[c] & & HC02196[e] & atp[n] h[n] h[n] fvs[c] leuktrB4wcooh[c] deoxfvs[c] M02112[c] 3hpvscoa[c] dhap[c] atp[c] nad[c] nadh[c] M01082[c] & xoltetrol[c] c101coa[c] & c101crn[c] c101crn[e] HC02195[e] h2o[c] h[c] & ppi[n] h2o[n] pi[c] h[c] crn[c] datp[c] nadp[c] h[c] nadph[c] nadph[c] nadp[c] ppi[c] nadh[c] tchola[e] h2o[n] pi[n] & & h[c] nadp[c] pchol_hs[e] & xolest2_hs[e] HC02204[e] prostge1[e] & & & & h2o[c] h2o[c] & nadp[c] h[c] nadh[c] ppi[c] HC02197[e] & & & & nadp[c] & h2o[n] & mi1p_D[n] atp[c] adp[c] & & xoltri27[c] & M00979[c] & M01084[c] & xol7ah3[c] & & & & & & nad[c] nad[n] nh4[n] pi[c] h[c] coa[c] & & pppi[c] pail5p_hs[n] pail_hs[n] h[c] h[c] h[c] c12dc[e] atp[c] & & hco3[c] & h[c] & & & & nadph[c] nadp[c] h[c] amp[c] hco3[c] & & & atp[c] adp[c] M01083[c] h[c] h2o[c] crn[c] coa[c] h2o[e] h[e]mag_hs[e] h2o[c] & & nadph[c] tudca3s[c] tudca3s[e] nad[c] coa[c] & & & h[c] h[n] & arg_L[c] ala_L[c] tyr_L[c] phe_L[c] trp_L[c] gly[c] hom_L[c] val_L[c] na1[e] pro_L[c] asn_L[c] thr_L[c] ile_L[c] cys_L[c] ser_L[c] gln_L[c] met_L[c] dadp[c] adp[c] crn[c] coa[c] omhdocosac[c] & docosdiac[c] docosdiac[e] phyt[c] hco3[e] 6pthp[c] & thbpt[c] & dhbpt[c] thbpt4acam[c] CE5236[c] atp[n] adp[c] 6pgl[c] C02528[e] nadph[c] h[c] atp[c] c10dc[c] c10dc[e] uri[n] uri[c] hco3[e] hco3[c] M00260[c] M00260[e] idp[c] h[c] tetdeca511ac[c] & tetdec2coa[c] & tetdec2crn[c] tetdec2crn[e] adp[n] atp[n] pi[n] dag_hs[e] & Rtotal[e] coa[c] crn[c] coa[c] HC02220[c] HC02195[c] & & decdicoa[c] & decdicrn[c] decdicrn[e] nad[c] h[c] HC02217[c] bildglcur[c] tchola[c] hco3[c] & prostge1[c] wharachd[c] bilglcur[c] nadp[c] & h2o[c] dctp[c] & gtp[n] & gdp[n] h2o[c] h2o[c] h[e] & na1[c] & na1[c] na1[c] & na1[c] & & cl[e] & & na1[c] & & na1[c] & na1[c] na1[c] & coa[c] HC02197[c] HC02204[c] HC02208[c] HC02214[c] hco3[e] nadh[c] HC02199[c] sebacid[c] hco3[e] hco3[e] pi[c] h[c] pi[c] h[c] & nadph[c] h2o[c] h[c] pi[c] hco3[e] gthrd[c] thyox_L[c] hco3[e] HC02198[c] hco3[e] nadh[c] datp[n] dadp[n] HC02201[c] gthrd[e] hco3[c] CE7081[e] c12dc[c] & c12dccoa[c] atp[c] amp[c] prostgi2[c] hco3[e] HC02187[c] hco3[e] triodthy[c] hco3[e] HC02180[c] HC02194[c] nadp[c] h[c] nad[c] adp[n] atp[n] atp[c] adp[c] 6pgc[c] co2[c] h[c] nadp[c] HC02210[c] HC02213[c] hco3[e] & h2o[n] & na1[e] & na1[c] atp[c] adp[c] g6p[c] h[c] h[e] pristanal[c] ppi[c] HC02206[c] hco3[e] HC02202[c] hco3[e] hco3[e] HC02216[c] hco3[e] h[c] nadph[c] nh4[n] h[n] adp[n] & & & & & & & & & & & & & & & & & h[c] na1[e] h2o[e] Rtotal2[e] amp[c] coa[c] HC02196[c] h[c] h[n] atp[n] h[c] na1[e] na1[e] na1[e] na1[e] cl[c] na1[e] na1[e] na1[e] na1[e] nadp[c] xylu_L[c] & 3dhguln[c] hco3[c] adp[c] hco3[c] M01080[c] phyt[e] h[n] CE5236[n] pi[n] pi[c] & rbl_D[c] nadp[c] nadh[c] nadph[c] dgtp[n] dgdp[n] CE2705[n] h[n] ttdcea[c] ttdcea[e] adrn[c] & adrn[e] & nadph[c] HC02200[c] crn[c] coa[c] h2o[c] h2o[c] & pi[c] ppi[c] & h2o[n] & nadh[c] & adp[c] sebacid[e] doco13ac[e] & doco13ecoa[c] & HC01254[c] duri[c] duri[n] & dcyt[n] dcmp[n] && dcdp[n] dctp[n] pi[c] adp[c]& h[c] & & atp[c] mag_hs[e] & glyc[e] & CE2705[c] & & adp[n] & arg_L[e] ala_L[e] tyr_L[e] phe_L[e] trp_L[e] gly[e] hom_L[e] val_L[e] na1[c] pro_L[e] asn_L[e] thr_L[e] ile_L[e] cys_L[e] ser_L[e] gln_L[e] met_L[e] atp[c] co2[c] & HC02199[e] HC02199[c] amp[c] coa[c] nad[c] h2o[n] hco3[c] h2o[c] h2o[c] & h[c] & hco3[c] & coa[c] dctp[n] dcdp[n] h2o[n] h2o[n] h2o[c] pi[c] h[c] atp[c] & h[c] hco3[c] pi[c] utp[n] ppi[c] hco3[e] CE5947[c] adp[c] h[c] g1p[c] nad[c] hco3[e] & ddece1crn[c] ddece1crn[e] M03134[e] c16dc[e] crn[c] HC02200[e] dcyt[c] pail3p_hs[n] ppi[n] pi[c] h[c] & & dd2coa[c] M03134[c] & M02694[c] & atp[c] h2o[c] udp[n] h[n] & atp[n] adp[n] atp[c] adp[c] nadph[c] hco3[e] hco3[e] & atp[c] h[c] pi[c] nadp[c] guln[c] h2o[c] adp[c] & 35cgmp[n] utp[n] udp[n] na1[e] & na1[c] atp[c] adp[c] nadp[c] nadph[c] h2o[c] atp[c] adp[c] h[c] nad[c] na1[c] h[c] h2o[c] dodecanac[c] nadh[c] c226coa[c] o2[c] hco3[e] na1[c] na1[e] h[c] crvnc[c] & c226crn[c] h[c] CE6247[c] M01389[c] atp[c] ppi[c] atp[c] & nadp[c] h2o[n] & tettet6[c] & tettet6[e] ru5p_D[c] & xyl_D[e] h2o[c] coa[c] h2o[c] atp[n] adp[n] h2o[c] atp[c] h[c] rbl_D[e] xu5p_D[c] xylt[c] xyl_D[c] & & h[c] h2o[c] & atp[n] tststeroneglc[c] & tststeroneglc[e] CE5945[c] & CE5946[c] h2o[c] HC02199[e] HC02201[e] tdchola[c] tdchola[e] amp[c] coa[c] h[n] adp[n] thbpt4acam[n] h2o[c] arachcoa[e] & CE2250[e] atp[c] h2o[c] h[e] xylt[e] HC02200[e] & h2o[c] h[c] coa[c] ppi[c] & h2o[c] glcur[c] CE7081[c] & CE7091[c] & 15HPET[c] 15HPET[e] & pi[c] h[c] pi[c] h[c] h[c] h[c] Glycolysis adp[c] nad[c] o2[c] hco3[c] c16dc[c] nadp[c] dctp[n] dcdp[n] h2o[n] h2o[c] leu_L[c] nadph[c] nadp[c] & CE2445[c] & CE2445[e] & hco3[e] malcoa[e] co2[e] pi[c] h2co3[e] hco3[e] & pi[c] h[c] & adp[c] h2o[c] thyochol[c] & gmp[n] atp[c] adp[c] atp[c] adp[c] h2o[c] nadp[c] pi[c] pi[c] atp[c] HC02200[e] HC02200[c] ptdcacoa[c] & ptdca[c] coa[c] atp[c] & ctp[n] cdp[n] & h2o[c] h[c] ptdca[e] & adp[c] nadp[c] h[c] atp[c] h[c] for[e] for[c] paps[c] C02528[c] h2o[c] h[c] prist[c] coa[c] & h[n] & & xylu_D[e] coa[c] & h[e] coa[e] h2o[c] h[c] gtp[n] gdp[n] dtdp[n] & & thr_L[c] h[c] nadph[c] adp[c] nadph[c] pi[c]adp[c] dadp[n] Inositol phosphat thyochol[c] & thyochol[e] mlthf[c] mlthf[e] nadph[c] adp[c] atp[c] & nadh[c] h2o[c] & nadp[c] coa[c] h[c] & nicrnt[c] nicrnt[n] gdp[n] & adp[n] h2o[c] h2o[c] hco3[e] hco3[c] crn[c] coa[c] & nadph[c] atp[n] gtp[n] atp[c] & h[c] e4p[c] g3p[c] & & M03050[c] M03051[c] crn[c] o2[c] adp[c] h[c] adp[c] h[c] hco3[e] hco3[c] o2[c] nadp[c] acac[e] acac[c] h[c] & HC02201[e] HC02201[c] & nadph[c] crn[c] coa[c] ctp[n] cdp[n] atp[n] dgtp[n] dgtp[c] atp[c] h[c] & xylu_D[c] nadp[c] h[c] h[e] & leuktrB4wcooh[c] CE6247[c] f26bp[c] f6p[c] r5p[c] udp[c] atp[c] & na1[c] & na1[e] M02837[e] & retinol[e] leuktrB4wcooh[e] atp[c] & coa[c] hco3[c] hco3[e] paps[c] tetdece1coa[c] & tetdece1crn[c] tetdece1crn[e] hexdicoa[c] clpndcrn[c] ppi[n] h[n] ump[n] & udp[n] & atp[n] cl[c] & & amp[c] pristcoa[c] & clpndcoa[c] & CE2705[e] ppi[n] & & & CE4989[c] & CE4988[c] rbt[c] & ppi[c] CE4821[c] & pail345p_hs[c] & & h2o[c] pi[c] & coa[c] h2o[c] h[c] atp[n] utp[n] udp[n] datp[n] & & pail34p_hs[c] pail3p_hs[c] atp[c] adp[c]CE7096[e] & glcur1p[c] 2hb[e] 2hb[c] & coa[c] amp[c] h2o[c] oh1[e] oh1[c] nadp[c] nadph[c] h[c] & pap[c] h[c] gcdca3s[e] & gcdca3s[c] atp[c] pi[c] amp[c] coa[c] h2o[c] co2[c] dnad[c] dnad[n] & nad[n] atp[n] 4abut[n] 4abut[c] pi[c] h[c] h2o[e] hdca[e] o2[c] amp[c] h[c] & pi[c] pi[c] pi[c] h2o[c] h[c] ppa[c] & ppa[e] HC02220[c] atp[c] taur[c] adp[c] coa[c] ppi[c] h2o[c] & & h2o[c] h[c] h[c] & atp[c] s7p[c] amp[c] ppi[c] h2o[c] atp[c] atp[c] adp[c] lys_L[e] ile_L[e] gln_L[e] pro_L[e] trp_L[e] asn_L[e] gly[e] cys_L[e] his_L[e] phe_L[e] val_L[e] hom_L[e] met_L[e] tyr_L[e] leu_L[e] ala_L[e] ser_L[e] h[c] h[c] h[c] atp[c] datp[n] dadp[n] h2o[c] o2[c] pi[c] HC02204[c] HC02204[e] utp[c] rbt[e] h[c] h[c] h2o[c] nadp[c] & nh4[n] amp[n] adp[n] h2o[c] & adpcoa[c] & adpac[c] M00265[e] M00315[e] dadp[n] h2o[c] h2o[c] atp[c] pi[c] prpp[c] coa[c] & amp[c] & & adp[c] h[c] & pi[c] pi[c] h[c] & nadp[c] & & & paps[c] pi[c] h2o[c] & thrnt[c] & thrnt[e] h[c] nadph[c] & r1p[c] h[c] nad[c] & na1[e] na1[e] na1[e] na1[e] na1[c] na1[e] na1[e] na1[e] na1[e] na1[c] CE6246[c] hco3[e] M00615[c] pap[c] ppi[c] atp[c] h[c] pi[c] amp[c] dgtp[n] dgdp[n] pi[n] h2o[c] pi[c] adp[c] atp[c] adp[c] & & & & & & & & & & & & & & & & & hco3[c] h[c] h[c] h[c] pap[c] CE4852[c] CE4848[c] coa[c] atp[c] pi[c] & & CE2915[e] & CE4722[e] CE4987[c] ump[c] dgchol[c] atp[c] coa[c] utp[c] utp[n] adp[n] datp[n] & nadh[c] h2o[c] gthrd[e] gthrd[c] nad[c] ppi[c] & rib_D[c] h[c] & adp[c] CE2510[e] h[n] adp[c] h2o[c] & nad[c] & & nad[c] nadh[c] h[e] crn[c] h[c] h2o[n] & h[c] h[c] pi[c] h[c] h2o[e] nadp[c] h2o[c] h[c] h2o[c] & & adp[c] h[c] adp[c] h[c] normete_L[c] normete_L[e] na1[c] nadp[c] CE5178[c] h[c] ppi[c] h2o[c] 2dr1p[c] ppi[c] & nadph[c] CE4817[c] coa[c] adp[c] atp[c] & & & & & & & & & & & ile_L[e] & nadh[c] atp[c] nadh[c] h2o[c] sbcoa[c] & nadp[c] dump[c] dump[n] atp[c] adp[c] na1[c] na1[c] & na1[c] na1[e] na1[c] na1[c] na1[c] na1[c] na1[e] coa[c] udp[c] subeac[c] subeac[e] h2o[c] clpnd[c] h2o[c] h2o[c] trdrd[n] & h[c] h[c] h[c] amp[c] adp[c] h2o[c] & & coa[c] & minohp[n] ppmi12346p[n] & & adp[c] adp[c] h[c] h2o[c] h2o[c] atp[c] & atp[c] nadp[c] h[c] h[c] h[c] h2o[c] CE2916[e] & CE4723[e] xoldiolone[c] & & & coa[c] coa[c] atp[c] accoa[n] h2o[c] h[c] h[c] o2[c] xoldioloneh[c] & thcholstoic[c] & rib_D[e] udpglcur[c] na1[c] coa[c] h[c] & atp[c] pi[c] pail35p_hs[c] & pi[c] h[c] HC02206[c] HC02206[e] xoltriol[c] & xoltetrol[c] & CE4872[c] cholcoar[c] h2o[c] crn[c] ppi[c] M03153[c] ppi[n] dttp[n] atp[c] & thexdd[c] thexdd[e] lys_L[c] ile_L[c] gln_L[c] pro_L[c] trp_L[c] asn_L[c] gly[c] cys_L[c] his_L[c] phe_L[c] val_L[c] hom_L[c] met_L[c] tyr_L[c] leu_L[c] ala_L[c] ser_L[c] & nadph[c] CE7096[c] atp[c] tcdca3s[c] h[c] & M02112[c] & atp[c] & & atp[c] & adp[c] & coa[c] coa[c] h2o[c] h2o[c] idp[n] h2o[n] trdox[n] & h2o[c] atp[c] adp[c] h2o[e] nadph[c] & nadph[c] h[c] o2[c] h[c] crn[c] CE5152[c] & CE5153[c] & o2[c] nadp[c] h2o[c] nad[c] h[c] c6dc[c] & & coa[c] amp[c] atp[c] pail45p_hs[c] adp[c] pi[c] h[c] o2[c] fdp[e] & & M00261[c] & & crn[c] nadp[c] h2o[c] nadp[c] h[n] & dutp[n] & pail5p_hs[c] hco3[e] hco3[c] h2o[c] amp[c] fdp[c] pi[c] adp[c] M00263[c] & CE4847[c] & M00265[c] M00315[c] h[c] atp[c] co2[c] & & cl[e] & CE2053[c] nadh[c] atp[c] 2dr5p[c] & drib[c] ppcoa[c] & coa[c] ppi[c] coa[c] datp[c] h[c] h2o[c] atp[c] adp[c] nrpphr[c] nrpphr[e] CE2917[e] CE4724[e] & gthrd[e] gthrd[c] & nadph[c] nadp[c] coa[c] r5p[c] dcholcoa[c] h[c] atp[c] M00702[c] h[c] atp[n] adp[n] CE2084[c] h2o[c] gly[c] na1[e] amp[c] coa[c] crn[c] nadph[c] M01776[c] & M00018[c] h2o[c] h2o[c] pi[c] atp[c] & nadph[c] & nadp[c] nadph[c] atp[c] pi[c] atp[c] coa[c] nadph[c] h[c] h[c] & M03014[c] & nadp[c] doco13ac[e] & & h[c] adp[c] nadp[c] ppi[c] dcsptn1[e] coa[c] M00315[c] clpnd[e] h2o[c] dudp[n] & h2o[e] nad[c] CE7097[c] h[c] nadph[c] h2o[c] nadp[c] h2o[c] h[c] nadph[c] thcholstoic[c] thcholstoic[e] nadph[c] C04805[e] M02977[c] h[c] & h2o[c] coa[c] adp[c] coa[c] & nadph[c] nadp[c] nadph[c] h[c] & h[c] & na1[c] na1[e] phe_L[e] HC02202[c] HC02202[e] nadp[c] & c8dc[c] & CE4819[c] amp[c] h2o[c] adp[c] atp[c] CE5944[c] nadh[c] dgchol[e] h[c] pi[c] coa[c] accoa[c] pi[c] nadph[c] atp[c] h[c] & o2[c] idp[c] adp[c] & na1[c] na1[e] & o2[c] xylu_D[c] h[c] & CE4850[c] M03016[c] thr_L[e] & nadph[c] pi[c] lac_L[e] lac_L[c] h[c] c6dc[e] nadph[c] h[c] trdox[c] dttp[c] dtdp[c] CE1950[e] cynt[e] h[c] adp[c] h2o[c] CE4854[c] octd11ecoa[c] pi[c] M02108[e] pi[c] pi[c] h2o[c] ppi[c] CE4851[c] & h2o[c] atp[c] nadp[c] & h[c] hco3[e] hco3[c] & atp[c] adp[c] h2o[c] co2[c] coa[c] atp[c] coa[c] ppi[c] & h2o[c] h2o[c] & gthrd[e] gthrd[c] & CE4844[c] CE4846[c] ppi[c] amp[c] amp[c] & pi[c] h[c] pi[c] h[c] h2o2[e] h2o[e] pi[c] & glyc_S[c] & M00021[e] nadph[c] h[c] amp[c] atp[c] adp[c] h[c] cys_L[e] h[e] h[c] fad[m] fadh2[m] amp[c] h[c] malcoa[c] h2o[c] h[c] CE2053[c] & h[c] CE4855[c] co2[c] & atp[c] adp[c] atp[c] adp[c] adp[c] 5HPET[e] & c8dc[e] ppi[c] CE2510[c] & h2o[c] atp[c] h[c] h2o[c] gthrd[e] glyc3p[c] & dhap[c] acac[e] 2hb[e] 2hb[c] acac[c] pi[c] nadp[c] h2o[c] nadph[c] nadp[c] acgpail_hs[c] nadh[c] hco3[c] CE7088[c] HC02213[c] HC02213[e] co2[c] & atp[c] udp[c] so3[e] h[c] h2o[c] xu1p_D[c] adp[c] & & coa[c] h2o[c] M01777[c] & CE5151[c] amp[c] & adp[c] & & C04805[c] nadp[c] adrncoa[c] CE7090[c] ppi[c] atp[c] idl_hs[e] ppmi12346p[c] tetdeca511ac[c] tetdeca511ac[e] nrvnc[e] & nrvnc[c] hco3[e] gthrd[c] h[c] coa[c] & malcoa[c] malcoa[c] coa[c] CE5154[c] minohp[c] gthox[c] gthrd[c] atp[c] & nad[c] & adp[c] co2[c] nadp[c] & & & M00879[c] & M00715[c] & h2o[c] CE4990[c] h2o[c] & o2[c] h2o[c] & nadph[c] h[c] & coa[c] crn[c] M02108[c] & M02107[c] & h[e] nadp[c] prostge1[c] coa[c] malcoa[c] doco13ac[c] h[c] h2o[c] h2o[c] h2o[e] & & prostge1[e] gthrd[e] CE4874[c] glyc_S[e] M00022[c] h[c] nadp[c] vacc[c] vacc[e] & pe12_hs[e] adp[c] atp[c] & hco3[e] & pyr[e] ppa[e] ppa[c] pyr[c] xol27oh[c] & h[c] co2[c] coa[c] ppi[c] pi[c] pi[c] h[c] pi[c] h[c] & 5HPET[c] gthrd[c] adp[c] h[c] nadp[c] coa[c] h[c] coa[c] nadph[c] atp[c] atp[c] & & 23cump[e] & 3ump[e] hco3[c] & dhcholestancoa[c] coa[c] adrn[e] & h[c] o2[c] & h[c] coa[c] h2o[c] h[c] h2o[c] h[c] cl[e] his_L[c] met_L[c] arg_L[c] phe_L[c] asn_L[c] ile_L[c] thr_L[c] val_L[c] hom_L[c] leu_L[c] pro_L[c] ala_L[c] gly[c] trp_L[c] tyr_L[c] gln_L[c] h[c] nad[c] nadh[c] nadh[c] atp[c] coa[c] h[c] atp[c] h[c] coa[c] h[c] coa[c] coa[c] pi[c] atp[c] adp[c] atp[c] adp[c] & & xol27oh[e] & h2o[c] atp[c] h2o[c] nadph[c] h[c] h2o[e] ac[e] coa[c] nadph[c] nadph[c] h2o[c] coa[c] h[c] & & nadp[c] hco3[e] dhap[c] glyald[c] & g3p[c] h2o[c] & nadp[c] nadph[c] atp[c] coa[c] & k[e] k[c] h2o[c] & HC02201[e] h[c] lac_L[e] h[e] lac_L[c] amp[c] h[c] M00260[c] & atp[c] ldl_hs[e] pail4p_hs[c] & pail_hs[c] phe_L[e] h[c] hco3[c] HC02201[c] co2[c] h[c] & h2o[c] CE4845[c] dcsptn1[e] h2o[c] malcoa[c] h[c] coa[c] coa[c] h2o[e] tdca3s[c] tdca3s[e] & & & & leuktrB4woh[c] o2[c] h[c] nadph[c] crn[c] h[c] h[c] dcsptn1[c] na1[e] na1[c] tmndnccoa[c] tmndnc[c] & CE7088[c] amp[c] h2o[e] & & uacgam[c] & & na1[c] & & na1[c] na1[c] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & na1[c] na1[c] na1[e] h[c] & ppi[c] atp[c] o2[c] & nadp[c] & for[c] glyc[e] pi[c] nad[c] o2[c] coa[c] h2o[c] formcoa[c] & h2o[e] h2o[c] ac[c] na1[c] & na1[e] & M02613[c] co2[c] & h[c] CE4853[c] CE4849[c] nadp[c] nadph[c] M00017[c] co2[c] ach[e] & chol[e] & CE5788[e] nad[c] & CE6234[c] gcald[c] & hpyr[c] & atp[c] amp[c] atp[c] h[c] nadp[c] & M00843[c] & hco3[e] hco3[c] na1[c] na1[e] h[c] atp[c] M03008[c] & M00023[c] M00021[c] nadph[c] nadph[c] & nadp[c] 2hb[e] & h[c] hco3[e] pi[c] nadph[c] h[c] atp[c] & nadh[c] malcoa[c] & h[c] nad[c] o2[c] h2o[c] atp[c] amp[c] & & & & & & & & & & & & & & & & hco3[c] atp[c] pi[c] & & & coa[c] h2o[c] & h[c] o2[c] & ppi[c] h[c] h[c] h[c] Rtotal[e] M01807[e] gpail_hs[c] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[c] h2o[e] h[e] gthrd[e] gthrd[c] adp[c] nad[c] h2o[c] coa[c] coa[c] h2o[c] coa[c] h2o[c] nad[c] pi[c] h[c] M01111[e] Glyoxylate decarbo ac[c] h2o[c] adrn[c] coa[c] o2[c] & & coa[c] ppi[c] & & 2hb[c] tag_hs[e] ac[e] h2o[e] h2o[e] ppi[c] nadph[c] ppi[c] & h[c] nadp[c] amp[c] atp[c] coa[c] coa[c] h[c] amp[c] atp[c] ppi[c] malcoa[c] & HC00005[e] h2o[c] coa[c] CE5786[e] leu_L[e] Leukotriene nadph[c] & h2o[c] h[c] h[c] atp[c] h[c] h[c] adp[c] pi[c] ppi[c] h2o[c] nad[c] ppi[c] coa[c] & coa[c] atp[c] h[c] crn[c] coa[c] nadph[c] nadph[c] pail_hs[e] atp[c] adp[c] leuktrB4[e] h2o[c] atp[c] h[c] malcoa[c] coa[c] h[c] h2o[c] nadp[c] cl[e] pa_hs[e] h[e] h[c] leuktrC4[e] & leuktrD4[e] & leuktrE4[e] o2[c] leuktrB4[c] & & h[c] & coa[c] M00008[e] & nadph[c] pa_hs[e] pe161_hs[e] & hexdeceeth[e] cl[c] his_L[e] met_L[e] arg_L[e] phe_L[e] asn_L[e] ile_L[e] thr_L[e] val_L[e] hom_L[e] leu_L[e] pro_L[e] ala_L[e] gly[e] trp_L[e] tyr_L[e] gln_L[e] h[e] HC01672[c] & eicostet[c] eicostetcoa[c] CE5144[c] pmtcoa[c] & ocdca[e] & stcoa[c] nadh[c] h2o[c] & & amp[c] h[c] & & CE5148[c] CE5150[c] nrvnccoa[c] M00234[e] & M00503[e] & & leuktrC4[c] CE7091[c] CE7085[c] & CE7085[e] & h[c] h[c] coa[c] nadp[c] nadph[c] dlnlcgcoa[c] arachdcoa[c] arachd[c] & coa[c] & & nadh[c] & tmndnccrn[c] CE5155[c] & CE5156[c] & CE5157[c] CE5158[c] & nadh[c] Rtotal2[e] tchola[c] tchola[e] HC02199[e] hco3[c] nadp[c] h[c] h2o[c] coa[c] pi[c] dlnlcg[e] dlnlcg[c] & & & amp[c] & amp[c] h2o[e] pa_hs[c] & & CE5789[e] h2o[e] gly[e] hco3[e] HC02199[c] h2o[c] ppi[c] amp[c] coa[c] crn[c] h[c] pchol_hs[e] & & & h[c] & dhcholestanate[e] nadph[c] h2o[c] & h[c]nadph[c] crn[c] h[c] Rtotal[e] tag_hs[e] pa_hs[e] o2[e] h2o[c] 23dpg[c] 13dpg[c] nadh[c] nadph[c] & h2o[c] coa[c] ppi[c] nadp[c] nadph[c] h[c] h2o[c] na1[c] na1[e] atp[c] amp[c] & & h[c] dhcholestanate[c] & M00085[c] & M00860[c] eidi1114ac[e] atp[c] coa[c] crn[c] o2[c] h2o[c] malcoa[c] nadp[c] h2o[c] coa[c] h[c] ppi[c] co2[c] for[e] pear_hs[e] & aracheth[e] CE6232[c] atp[c] amp[c] h[c] amp[c] nadp[c] coa[c] h[c] amp[c] h2o[c] ppi[c] atp[c] vacccrn[c] & & malcoa[c] co2[c] nadp[c] h2o[c] chsterol[e] mi3p_D[c] gthrd[c] o2[c] nadh[c] coa[c] ppi[c] amp[c] pi[c] & coa[c] vacccoa[c] cl[c] & & ppi[c] & CE5787[e] & h[c] h[c] na1[c] na1[e] h[c] ppi[c] h[c] malcoa[c] o2[c] ppi[c] HC00009[e] coa[c] coa[c] hco3[c] adp[c] & xoltri27[e] coa[c] & co2[c] & crn[c] amp[c] & h2o[c] tetdecaeth[e] h2o[c] h2o[c] HC02200[e] HC02200[c] h[c] nad[c] accoa[c] adrncoa[c] & CE4834[c] coa[c] didecaeth[e] dha[e] & dhap[e] pi[c] h[c] hco3[e] & & nadp[c] & M02103[c] adp[c] nadp[c] adp[c] coa[c] dcsptn1coa[c] & nad[c] & h2o[e] pchol_hs[e] gacpail_hs[c] h2o[e] CE0347[c] o2[c] atp[c] h[c] glyc_R[e] adp[c] xoltri27[c] co2[c] coa[c] crn[c] h[c] h[c] h2o[c] HC00009[e] HC00005[e] pa_hs[e] ocdcea[e] & odecoa[c] glyclt[e] glyclt[c] glyc_R[c] nadp[c] & nadph[c] co2[c] & atp[c] coa[c] atp[e] h[c] atp[c] & adp[c] leu_L[e] CE5791[e] h2o[c] & & h[c] h2o[c] pi[c] h2o[c] nadph[c] nadh[c] nadp[c] coa[c] M01197[c] h[c] coa[c] pi[c] h[e] cys_L[c] h[c] o2[c] h2o[c] h2o[c] coa[c] & atp[c] & crn[c] h[c] ldl_hs[e] & HC00005[e] M00234[e] & h[c] h2o[c] h2o[c] h2o[c] & & h2o[c] ppi[c] h[c] coa[c] h[c]nadph[c] crn[c] co2[c] coa[c] & HC00005[e] h[e] adp[e] & na1[e] atp[c] & h[c] h[c] atp[c] nadp[c] h2o[c] CE4833[c] malcoa[c] eicostet[e] & coa[c] coa[c] h2o[e] dag_hs[c] na1[c] nadp[c] & & h[c] co2[c] coa[c] lneldccoa[c] lneldc[c] h[c] inost[e] tchola[e] tchola[c] h2o[c] hco3[c] hco3[e] C06314[c] tmndnc[c] & CE6508[c] CE7079[c] & CE7083[c] & acald[c] nad[c] h[c] lneldccrn[c] & & atp[c] adp[c] pi[c] h[c] HC02201[c] HC02201[e] & C06314[e] & CE7083[e] nadp[c] nadp[c] amp[c] nadph[c] h2o[c] dlnlcgcrn[c] & nadph[c] nadp[c] h2o[c] Rtotal2[e] h[e] na1[e] met_L[e] & dlnlcg[c] & CE6230[c] & CE2537[c] & h2o[c] h[c] nadph[c] & h2o[c] coa[c] atp[c] h[c] coa[c] h2o[c] & h[c] coa[c] malcoa[c] h2o[c] CE5114[c] coa[c] M01727[c] doco13ac[c] & na1[c] & & atp[c] adp[c] h[e] & h2o[c] h[c] crn[c] Rtotal3[e] dag_hs[e] M02956[e] & M01807[e] gthrd[c] gthrd[e] CE5797[e] & CE5798[e] adp[c] h2o[c] crn[c] h[c] & coa[c] CE4812[c] CE4810[c] & CE4811[c] h2o[c] nadp[c] & Rtotal3[e] g6p[c] & h[c] h2o[c] atp[c] coa[c] & h2o[c] eicostetcrn[c] h[c] & pa_hs[e] & hco3[c] hco3[e] & h[c] h2o[c] M00008[c] h[c] malcoa[c] na1[c] na1[e] h2o[e] na1[e] h2o[c] nadph[c] h[c] adp[c] nadh[c] M00054[c] & & CE4843[c] & eidi1114ac[c] lnlncg[e] coa[c] & amp[c] glyc[e] chsterol[e] h2o[c] h[c] paf_hs[c] & paf_hs[e] gthrd[c] hco3[c] hco3[e] gthrd[e] pi[c] pi[c] xol7ah2al[c] M02611[c] & M02612[c] & coa[c] nadph[c] nadp[c] nad[c] h2o[c] nrvnc[c] & nrvnc[e] & h2o[c] h2o[e] atp[c] nadp[c] h2o[c] na1[c] h[c] & M00100[c] na1[c] h[c] h2o[c] C06315[c] & & crn[c] arachdcrn[c] nadp[c] coa[c] co2[c] h[c] inost[e] pi[c] h[c] C06315[e] h2o2[c] 2pg[e] nadp[c] nadph[c] nadh[c] nadp[c] h2o[c] coa[c] amp[c] h2o[c] coa[c] ppi[c] & glx[e] glx[c] 2pg[c] h2o[c] h[c] atp[c] & co2[c] o2[c] h2o[c] M00122[c] coa[c] CE5867[e] & CE5868[e] nadph[c] & h[c] h2o[c] h[c] atp[c] h[c] coa[c] strdnc[e] & h2o[c] M01191[c] & peole_hs[e] & oleth[e] h[c] pi[c] & atp[c] adp[c] coa[c] ppi[c] leuktrA4[e] & 3pg[c] & co2[c] CE4831[c] dcsptn1crn[c] nadh[c] malcoa[c] M02457[c] gln_L[c] ala_L[c] ser_L[c] hom_L[c] val_L[c] pro_L[c] tyr_L[c] trp_L[c] gly[c] cl[e] leu_L[c] phe_L[c] cys_L[c] asn_L[c] thr_L[c] ile_L[c] gln_L[c] lys_L[c] leuktrA4[c] CE2567[c] & h[e] h[c] h[c] nad[c] h[c] h[c] h[c] malcoa[c] nadp[c] na1[e] coa[c] & & & h[c] coa[c] ppi[c] & adrncrn[c] coa[c] h2o[c] na1[e] na1[c] h2o[c] & atp[c] amp[c] & & lnlncg[c] coa[c] CE4791[c] & pmtcrn[e] pmtcrn[c] nadh[c] crn[c] coa[c] mi1p_D[c] & inost[c] & glcur[c] h2o[c] & & & malcoa[c] M01237[c] M01238[c] & atp[c] & HC00006[e] tcdca3s[c] tcdca3s[e] HC02199[c] hco3[c] hco3[e] HC02199[e] o2[c] h2o2[c] o2[c] xol7ah3[c] M00873[c] coa[c] & nadp[c] & & h2o[c] h2o[e] pi[c] & CE5869[e] nadp[c] atp[c] h[c] nadph[c] nadp[c] nad[c] nadph[c] amp[c] o2[c] nadp[c] & crn[c] nadp[c] dag_hs[c] h[c] & na1[e] na1[c] & na1[c] & & na1[c] & & na1[c] & na1[e] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & h[e] nadph[c] CE7172[c] CE7172[e] & adp[c] glyclt[c] nad[c] M00790[c] crn[c] h[c] h2o[c] o2[c] & & crn[c] h[c] h2o[c] coa[c] & h2o[c] hdca[e] & pmtcoa[c] h2o[e] & & so3[c] & nadh[c] amp[c] & & h[c] h2o[c] h[c] h2o[e]& h2o[e] h2o[e] h2o[e] h2o[e] pedh203_hs[e] & diholineth[e] hco3[e] hco3[c] h[c] o2[c] M00625[c] nadph[c] h[c] nadp[c] atp[c] h[c] nadph[c] nadph[c] h[c] malcoa[c] o2[c] nad[c] cbl2[c] pchol_hs[e] pi[c] o2[c] h2o[c] atp[c] & nadh[c] o2[c] h[c] coa[c] & & co2[c] coa[c] M00101[c] h[c] glyc[e] h2o[c] HC02200[c] o2[c] adp[c] & o2[c] nadp[c] ppi[c] ppi[c] h[c] malcoa[c] M00123[c] & & pi[c] h2o[c] h2o[c] HC02200[e] & nadp[c] coa[c] coa[c] & nadp[c] nadph[c] malcoa[c] coa[c] M01207[c] & amp[c] ppi[c] h[c] & & hco3[c] hco3[e] h2o[c] pi[c] trdrd[c] & trdox[c] h2o[c] & crn[c] nadph[c] & & h2o[e] ac[e] & & h2o[c] h2o[c] pi[c] h[c] pi[c] h[c] & & & & & & & & & & & & & & & & & & h2o[c] h[c] Eicosanoid Metabolism nad[c] malcoa[c] coa[c] crn[c] coa[c] nadph[c] nadp[c] coa[c] nadph[c] & coa[c] & na1[c] na1[e] na1[e] na1[e] na1[e] na1[c] na1[e] na1[e] na1[e] na1[e] CE4633[e] & CE4881[e] 15HPET[c] h2o[c] pi[c] nadph[c] M01770[c] nadph[c] h[c] h2o[c] h[c] h2o[c] nadp[c] nadph[c] pmtcrn[c] pchol_hs[e] Rtotal[e] & pa_hs[e] CE1401[e] o2[c] h2o[c] h2o[c] h[c] lneldccrn[e] nadp[c] h2o[c] atp[c] adp[c] atp[c] adp[c] etoh[c] etoh[e] & M00011[c] & M03005[c] M00086[c] amp[c] o2[c] crn[c] tag_hs[e] Rtotal[e] Rtotal[e] h2o[c] pi[c] no2[e] h2o[c] h[c] adp[c] nadph[c] nadp[c] & M00012[c] coa[c] ppi[c] o2[c] co2[c] & Rtotal[e] Rtotal[e] dag_hs[c] gthrd[c] gthrd[e] C14770[c] h2o[c] so4[e] h2o[c] lnlncgcoa[c] & CE4793[c] & octd11ecoa[c] & ocdececrn[c] ocdececrn[m] coa[c] h[c] h[c] h[c] & h[c] mi14p[c] mi3p_D[c] & & C02712[e] h[c] lnlncgcrn[c] & CE4835[c] h[c] h2o[c] nadp[c] strdnccoa[c] strdnc[c] & atp[c] coa[c] HC00009[e] gln_L[e] ala_L[e] ser_L[e] hom_L[e] val_L[e] pro_L[e] tyr_L[e] trp_L[e] gly[e] cl[c] leu_L[e] phe_L[e] cys_L[e] asn_L[e] thr_L[e] ile_L[e] gln_L[e] lys_L[e] hco3[c] CE2537[e] hcys_L[e] so4[c] 2pg[c] hpdcacrn[c] h2o[c] h[c] & h2o[c] & h2o[c] nadh[c] paf_hs[e] & ak2lgchol_hs[e] tca3s[c] tca3s[e] pcholn226_hs[c] pcholn226_hs[e] C14771[c] atp[c] pi[c] & M00778[c] M00044[c] nadp[c] & h2o[c] crn[e] hdcea[e] h2o[e] & mi13p[c] & hco3[e] paps[c] h[c] amp[c] h[c] & ocdca[e] & nad[c] & pi[c] Miscellaneous 5HPET[e] 5HPET[c] o2[c] fad[c] & o2[e] o2[e] h2o2[e] & crn[c] coa[c] crn[c] amp[c] ppi[c] nadh[c] coa[c] h[c] hdca[c] & coa[c] na1[e] & fad[c] pap[c] na1[e] xol7ah2[c] & CE0233[c] ppi[c] atp[c] nad[c] pmtcoa[c] M02745[c] h2o[c] h[c] na1[c] h[c] h[e] pe226_hs[e] & docohxeth[e] hco3[e] hco3[c] h2o[c] nadp[c] coa[c] malcoa[c] h[c] h[c] nadph[c] & mi145p[c] pi[c] & o2[c] CE7082[c] CE7082[e] nadp[c] C14825[e] & M00341[c] h2o[c] amp[c] coa[c] coa[c] & crn[c] & h[e] h[e] h[e] pi[c] h[c] nadph[c] nadp[c] hyptaur[e] & taur[e] ptrc[e] & 4abutn[e] nadph[c] h[c] adp[c] & atp[c] h[c] o2[c] co2[c] h[c] nadph[c] & aqcobal[c] HC00007[e] HC00008[e] h2o[c] h2o[c] HC02199[c] nad[c] ppi[c] & & & h[c] nadph[c] nadp[c] hdcecrn[c] & pi[c] hco3[c] h2o[c] o2[c] h2o[c] oxa[c] & oxa[e] h[c] nadph[c] & coa[c] h[c] atp[c] amp[c] coa[c] o2[c] hdcoa[c] hdcea[c] & hdd2coa[c] & hdd2crn[c] h[e] h2o[c] pi[c] h[c] atp[c] adp[c] CE5854[e] & CE1926[e] hco3[e] HC02199[e] gthrd[c] nadp[c] coa[c] coa[c] atp[c] h2o[c] o2[c] M03017[c] nadp[c] & coa[c] atp[c] & & magole_hs[e] h[e] & nh4[e] nadph[c] & coa[c] coa[c] h2o[c] & h[c] M00871[c] & M00704[c] na1[e] ppi[c] coa[c] hdd2crn[c] VitB12 & pa_hs[e] h2o[c] & h2o[e] h2o[c] co2[c] h[c] nadph[c] nadp[c] crn[c] atp[c] adp[c] & fadh2[c] h[c] pi[c] coa[c] & h[c] & h2o[c] atp[c] crn[c] coa[c] Rtotal2[e] & h2o[e] & o2[c] 12HPET[c] & CE0347[c] h[c] pi[c] hco3[e] hco3[c] h2o[c] atp[c] & vacc[e] nadph[c] h2o[c] coa[c] coa[c] atp[c] h2o[e] pa_hs[e] pi[c] h2o[c] pchol2linl_hs[c] pchol2linl_hs[e] h[e] o2[c] txa2[c] txa2[e] 2amac[c] & Lcyst[c] h2o[c] xol7aone[c] & coa[c] h[c] h[c] lneldccrn[c] h[c] nadp[c] na1[c] HC00006[e] met_L[c] glcur[e] & & & h2o[c] xol7ah[c] nadp[c] h2o[c] & M02102[c] & coa[c] o2[c] nadph[c] ppi[c] nadph[c] atp[c] h2o[c] maglinl_hs[e] magarachi_hs[e] magste_hs[e] fadh2[c] na1[c] nad[c] & h2o[c] & amp[c] M00869[c] coa[c] amp[c] malcoa[c] & mi4p_D[c] sphs1p[c] & sphs1p[e] h[c] CE4842[c] & eic21114tr[c] nadph[c] coa[c] h2o[c] malcoa[c] h2o[e] h2o[c] & pi[c] 12HPET[e] h2o[c] gthox[c] akg[c] dkmpp[c] & dhmtp[c] & atp[c] coa[c] & ocdca[c] co2[c] & coa[c] pe15_hs[e] atp[c] gly[e] HC02201[c] hco3[e] M02053[c] coa[c] strdnccrn[c] o2[c] & & h2o[c] pi[c] h[c] & h[c] M02051[c] & M02052[c] h2o[c] atp[c] M00862[c] M00010[c] ppi[c] nadh[c] co2[c] HC00009[e] Rtotal3[e] pe224_hs[e] & docteteth[e] pelinl_hs[e] & lineth[e] & pi[c] h[c] hco3[c] h2o[c] & dmgly[c] & sarcs[c] na1[c] h2o[c] nadp[c] & co2[c] & magpalm_hs[e] h2o[c] pi[c] CE5853[e] & CE1925[e] adp[c] CE1401[c] o2[c] nadh[c] & C14825[c] coa[c] nad[c] coa[c] h[c] amp[c] atp[c] adp[c] & h2o[c] crn[c] nadph[c] h2o[c] M00343[c] nadp[c] h[c] & aqcobal[e] h2o[c] atp[c] adp[c] & & ac[c] & h[c] amp[c] atp[c] nadph[c] h[c] & nadp[c] nadph[c] & CE5162[c] h2o[c] h2o[c] cl[c] & nadh[c] & & h2o[c] nadp[c] amp[c] & & arachd[e] na1[e] h[c] atp[c] & ahcys[c] h[c] & odecoa[c] adp[c] atp[c] na1[c] HC02201[e] na1[e] glu_L[c] met_L[e] na1[e] & C02712[c] ppi[c] & pa_hs[e] xolest2_hs[c] & pchol2ole_hs[c] pchol2ole_hs[e] amet[c] pi[c] pep[c] coa[c] h[c] o2[c] M00712[c] h2o[c] crn[c] & h2o[c] ppi[c] Rtotal[e] h2o[e] h2o[e] sphmyln_hs[c] sphmyln_hs[e] o2[e] arachd[c] o2[c] h2o[c] & & nadph[c] h[c] o2[c] h2o[c] coa[c] & nadph[c] h2o[c] & nad[c] txb2[c] crn[c] CE4840[c] pi[c] o2[c] o2[c] nadp[c] h[c]& coa[c] coa[c] nadp[c] & & mi1345p[c] & mi134p[c] & mi34p[c] 3spyr[c] & nadp[c] ppi[c] stcoa[c] amp[c] h[c] h2o[c] ppi[c] coa[c] HC00008[e] h2o[c] h2o[c] h[c] h[c] o2[c] h[c] crn[c] h[c] h[c] atp[c] HC00004[e] lpchol_hs[c] fe2[e] & fe3[e] & ile_L[c] M00245[c] malcoa[c] nadp[c] & nad[c] ppi[c] & h2o[c] pi[c] h[c] pi[c] h[c] HC02200[c] nadph[c] nadh[c] h2o[c] & co2[c] nadph[c] adp[c] & amp[c] h[c] h2o[e] h[c] h[c] ala_D[c] arg_L[c] leu_L[c] met_L[c] hom_L[c] val_L[c] asn_L[c] ala_L[c] cys_L[c] gln_L[c] ile_L[c] thr_L[c] pro_L[c] phe_L[c] trp_L[c] ser_L[c] adp[c] hco3[c] HC02200[e] & & Lcyst[e] cl[e] nadh[c] h[c] 5mthf[c] thf[c] na1[c] for[c] eic21114tr[e] nadph[c] M03006[c] M00342[c] nadph[c] nadh[c] & h[c] coa[c] crn[c] HC00004[e] pa_hs[e] atp[c] adp[c] adp[c] hco3[e] h[c] atp[c] for[c] co2[c] coa[c] M00887[c] M00004[c] amp[c] coa[c] o2[c] nadh[c] nadph[c] lipoate[e] & pi[c] atp[c] adp[c] atp[c] adp[c] & nadp[c] & & hpdcacoa[c] & ppi[c] nadph[c] crn[c] h2o[c] h[c] & co2[c] h2o[c] h[c] pi[c] h[e] fadh2[c] h[c] h[c] & h[c] & & o2[c] o2[c] M02976[c] & M01141[c] HC10784[c] M00117[c] HC00007[e] h[c] ahcys[c] amet[c] ahcys[c] h2o[c] h[c] chol[c] pi[c] pi[c] h2o[e] h[c] h[c] o2[c] h2o[c] h[c] atp[c] nadph[c] ocdcea[c] ocdcea[e] h2o[c] pa_hs[e] amet[c] chsterol[c] h2o[c] & & & & h2o[c] C14771[c] h2o[c] h[c] ile_L[e] o2[c] cdp[c] coa[c] h[c] nadph[c] stcrn[c] & & & coa[c] h2o[c] h2o[c] h2o[c] HC02076[c] & HC02042[c] h[c] cl[e] & & &na1[e] & h[e] & na1[c] na1[c] & na1[c] & & na1[c] & & na1[c] na1[c] na1[c] na1[c] & & CE1447[e] & h2o2[c] M00907[c] malcoa[c] h2o[c] h[c] coa[c] crn[c] nadp[c] pi[c] sphmyln1825_hs[c] sphmyln1825_hs[e] pchol2ste_hs[c] pchol2ste_hs[e] CE1447[c] & h2o[c] nh4[c] amp[c] amp[c] h2o[c] h[c] h[c] crn[c] amp[c] h[c] o2[c] nad[c] hcys_L[c] & met_L[c] 2kmb[c] co2[c] & lnlc[c] coa[c] coa[c] adp[c] malcoa[c] h2o[c] nadp[c] atp[c] hdl_hs[e] M02686[c] & M02758[c] & pchol_hs[c] & HC02050[c] & HC02056[c] & h[c] pi[c] & & h[c] & & coa[c] crn[c] coa[c] nadp[c] na1[e] h2o[c] atp[c] o2[c] atp[c] Meth_cys & & CE4841[c] lnlccoa[c] & h[c] nadph[c] ppi[c] CE5161[c] na1[e] pi[c] h[c] h2o[c] adp[c] h[c] h2o[c] adp[c] pi[c] adp[c] ppi[c] malcoa[c] & h2o[c] nadp[c] HC10859[c] & & CE5160[c] HC02054[c] & dhap[e] glyc[c] h[c] nadh[c] h2o[c] h[c] & ppi[c] coa[c] nadph[c] malcoa[c] & accoa[c] & co2[c] h2o[c] hepdeceth[e] HC02060[c] & HC02070[c] pi[c] h[c] & & & & & & & & & & & & & & & & & & dha[e] h2o[c] & pi[c] h[c] sl_L[c] gthrd[c] hcys_L[c] atp[c] pi[c] atp[c] & & h[c] coa[c] acrn[c] coa[c] & inost[c] cmp[c] atp[c] adp[c] cl[c] na1[c] h[c] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] o2[c] C14771[e] h2o[c] nadph[c] h[c] & co2[c] crn[c] h2o[c] malcoa[c] pi[c] nadph[c] pendecaeth[e] & atp[c] & glu_L[c] atp[c] h[c] malcoa[c] atp[c] cmp[c] atp[c] adp[c] & fad[c] & akg[c] gdp[c] coa[c] malcoa[c] h[c] & M00707[c] atp[c] coa[c] nadph[c] nadp[c] & ahcys[c] h[c] h2o[e] pi[e] nadph[c] h[c] gtp[c] & o2[c] nadp[c] M00116[c] & M00852[c] h[c] h[c] & nadph[c] amet[c] h[c] cdpchol[c] & C13856[c] & ppi[c] & & & coa[c] HC02048[c] sphmyln1824_hs[c] sphmyln1824_hs[e] etha[c] Lhcystin[c] & gthox[c] & gthox[e] ala_L[c] h[c] gdp[c] coa[c] & & h[c] h[c] hco3[c] o2[c] & ala_D[e] arg_L[e] leu_L[e] met_L[e] hom_L[e] val_L[e] asn_L[e] ala_L[e] cys_L[e] gln_L[e] ile_L[e] thr_L[e] pro_L[e] phe_L[e] trp_L[e] ser_L[e] h2o[c] & hpdca[c] h[c] & pcholar_hs[c] pcholar_hs[e] h2o[c] h[c] adp[c] h[c] coa[c] nadh[c] & co2[c] h[c] h[c] h[c] coa[c] h2o[c] Arachidonic acid pi[c] & coa[c] coa[c] nad[c] 4mtob[c] & 3mtp[c] 3mtp[e] coa[c] coa[c] nadph[c] o2[c] h[c] h2o[c] fadh2[c] nadp[c] C14770[c] h2o[c] sl_L[e] & atp[c] h[c] h[c] malcoa[c] crn[c] & crn[c] h2o[c] na1[c] pi[c] h[c] h2o[c] HC01441[e] & lcts[e] amet[c] h[c] crn[c] crn[c] M02973[c] Lipoate atp[c] adn[c] h2o[c] h[c] h[c] & & pi[c] h[c] co2[c] & h2o[c] h[c] lnlccrn[c] coa[c] co2[c] tdcoa[c] & ttdca[c] atp[c] adp[c] C14769[c] hco3[e] gthrd[e]hco3[c] gthrd[c] dgdp[c] adp[c] nadp[c] coa[c] & coa[c] h2o[c] adp[c] na1[e] o2[c] h2o[c] nadph[c] nadp[c] h2o[c] ppi[c] atp[c] adp[c] h2o[c] C11695[c] h2o[c] & & & & M02637[c] & lnlncacoa[c] & lnlncacrn[c] nadp[c] & amp[c] na1[c] h[c] adp[c] HC01446[e] & HC01440[e] C14769[c] fad[c] cyan[c] h[c] M00802[c] M03047[c] M03045[c] M00003[c] coa[c] nadph[c] & atp[c] & hco3[c] hco3[e] cyan[e] M00067[c] & & h2o[c] coa[c] & sphmyln18118_hs[c] sphmyln18118_hs[e] & HC02180[c] HC02180[e] tcynt[e] so3[e] h[c] oaa[c] crn[c] coa[c] coa[c] h[c] h[c] ser_L[c] h[c] amp[c] & M03018[c] M00839[c] & M00699[c] M03011[c] crn[c] & o2[c] coa[c] pcholdoc_hs[c] pcholdoc_hs[e] & h2o[c] tcynt[c] h[c] & M00127[c] ahcys[c] ficytC[m] focytC[m] & amp[c] atp[c] odecrn[c] nadph[c] nad[c] gly[c] h2o[e] adp[c] lac_L[e] lac_L[c] nh4[c] & h2o[c] udp[c] & & nadph[c] nadp[c] & h[c] 7ohocata[e] h[c] h2o[c] pi[c] ppi[c] na1[c] h[c] ppi[c] h2o[c] h[c] pi[c] pi[c] h[c] h2o[c] C13856[e] h2o[c] mercplaccys[c] & h[c] & h2o[c] nadp[c] M02638[c] nadph[c] h[c] co2[c] nadph[c] pa_hs[e] & h2o[c] coa[c] & & amp[c] h[c] & h2o[e] pi[c] h[c] nadh[c] c3dc[e] malcoa[c] h[c] atp[c] dhlam[c] & lipoate[c] h[c] atp[c] adp[c] arg_L[e] arachd[e] & 12HPET[e] h2o[c] hpdca[e] ppi[c] coa[c] isomal[e] & glc_D[e] prostgi2[e] prostgi2[c] CE0955[c] & CE0955[e] h[c] so3[c] & so4[c] coa[c] h2o[c] nadp[c] h2o[c] chol[c] atp[c] adp[c] pi[c] atp[c] h[c] & dadp[c] nadph[c] atp[c] malcoa[c] coa[c] & nadh[c] nadh[c] pepalm_hs[e] & pmeth[e] HC00250[c] & nadp[c] lnlccrn[e] nad[c] & ttdcrn[c] & M00129[c] & & nadh[c] na1[c] h[c] pchol_hs[c] & sphmyln181181_hs[c] sphmyln181181_hs[e] & h2o[c] adp[c] h[e] nadh[c] nad[c] utp[c] h[c] h[c] lnlnca[e] lnlnca[c] & crn[c] o2[e] C14770[e] & h[c] h[c] h[c] nad[c] nad[c] acac[c] h2o[c] coa[c] nad[c] h2o[c] pe2linl_hs[e] pear_hs[e] pe14_hs[e] pe15_hs[e] adp[c]pe161_hs[e] adp[c] pcholeic_hs[c] pcholeic_hs[e] C11695[e] h[c] atp[c] & acac[e] na1[e] & & ttdca[c] pe203_hs[c] h[c] pe203_hs[e] pe224_hs[e] pe226_hs[e] pi[c] pe17_hs[e] h2o[c] HC01104[e] & 4nph[e] adp[c] akg[c] h[c] coa[c] h[c] amp[c] h2o[c] pi[c] pi[c] pi[c] h[c] hco3[e] h2o[c] mercplac[c] & h[c] glu_L[c] dgtp[c] datp[c] lald_L[c] & co2[c] h[c] coa[c] pi[c] h2o[e] C14769[e] h2o[c] C14768[c] & pi[c] ctp[c] g3p[c] dhap[c] & h[c] nadp[c] h2o[c] coa[c] ppi[c] h[c] adp[c] adp[c] adp[c] h2o[e] Rtotal2[e] h2o[c] pi[c] lac_L[c] gtp[c] & methsuccoa[c] & methsucc[c] methsucc[e] c3dc[c] crn[c] h[c] coa[c] h[c] nadp[c] adp[c] h[c] h[c] atp[c] adp[c] pi[c] h[c] 2obut[e] mercppyr[c] h[c] & & h2o[c] coa[c] nadp[c] h2o[c] & ttdcrn[e] pedh203_hs[e] pi[e] C04849[e] hco3[c] & 2obut[c] & nad[c] 3sala[c] & 3snpyr[c] 12ppd_S[c] coa[c] & h[c] atp[c] pi[c] h[c] CE5304[e] cyst_L[c] glu_L[c] h2o[c] nadh[c] pyr[c] & adp[c] pi[c] pi[c] pi[c] adp[c] atp[c] adp[c] gly[c] thr_L[c] leu_L[c] phe_L[c] met_L[c] gln_L[c] ile_L[c] his_L[c] ala_L[c] ser_L[c] trp_L[c] cys_L[c] hom_L[c] lys_L[c] cl[e] CE4877[c] atp[c] coa[c] coa[c] M00020[c] & & ser_L[c] pi[c] pchol_hs[e] & lpchol_hs[e] & CE4877[e] & h[c] nad[c] & M00115[c] nad[c] coa[c] & sphmyln18117_hs[c] sphmyln18117_hs[e] HC01444[e] & glyc[e] gthrd[c] gthrd[e] & h[c] nh4[c] nadp[c] M01775[c] & M01236[c] & M01235[c] M00006[c] M01582[c] h2o[c] & h[c] h[c] h[c] nadph[c] h[c] C14768[e] HC00250[c] & atp[c] coa[c] & & h[c] h2o[c] atp[c] & & & nadp[c] nh4[c] h2o[c] & pi[c] h[c] & & crn[c] adp[c] & & & atp[c] h2o[c] akg[c] so3[c] h[c] h2o[c] h[c] coa[c] h[c] amp[c] crn[c] amp[c] 7ohocata[c] atp[c] atp[c] pcholet_hs[c] pcholet_hs[e] na1[c] na1[c] h[c] na1[c] na1[e] na1[c] na1[c] na1[e] & & co2[c] co2[c] crn[c] ppi[c] coa[c] atp[c] atp[c] coa[c] coa[c] & atp[c] atp[c] atp[c] atp[c] h[e] pi[c] h[c] & & & & & & & & & & & & & & & h2o[c] atp[c] amp[c] h2o[c] & amp[c] h2o[c] coa[c] co2[c] atp[c] & h2o[c] h2o[e] & 15kprostgf2[c] pyr[e] elaid[e] elaid[c] lgnc[e] nadp[c] h2o[c] h2o[c] h2o[c] & ppi[c] h[c] h2o[c] h[c] atp[c] h2o[c] h2o[c] atp[c] adp[c] h2o[c] gal[e] adp[c] atp[c] CE0737[e] lac_L[e] nadp[c] & & pi[c] h[c] but[c] & btcoa[c] & ethmalcoa[c] & ethmalac[c] ethmalac[e] malcoa[c] o2[c] & h2o[c] ppi[c] coa[c] ppi[c] atp[c] atp[c] pe226_hs[c] h2o[c] pe13_hs[c] pe15_hs[c] h[c] pi[c] h[c] h[c] nadp[c] h[c] but[e] & h2o[c] h2o[c] adp[c] nad[c] nadph[c] nadph[c] coa[c] coa[c] nadh[c] h[c] coa[c] pe161_hs[c] 12dgr120[e] & & & & & & & & & & & & & C05957[e] C05957[c] CE4876[c] & pi[c] h2o[c] cys_L[c] nadh[c] nadph[c] ppi[c] atp[c] amp[c] ttdceacoa[c] h2o[c] pe224_hs[c] pe2linl_hs[c] pear_hs[c] pe14_hs[c] pe17_hs[c] cmp[e] atp[c] adp[c] na1[e] na1[e] h[e] na1[e] na1[c] na1[e] na1[e] na1[c] 15kprostgf2[e] h[c] HC01501[c] na1[c] & CE2251[c] M01726[c] & o2[c] ttdcea[c] & & sphmyln18116_hs[c] sphmyln18116_hs[e] 15kprostgf2[c] & & & 2hb[c] na1[e] coa[c] & CE2247[c] CE2243[c] arachcrn[c] nadph[c] h[c] & mthgxl[c] acetol[c] 2hb[e] & h2o[c] h[c] h[c] h[c] h[c] pedh203_hs[c] h2o[c] HC02161[e] & HC02160[e] & o2[c] & & pmtcoa[c] ppi[c] h[c] atp[c] coa[c] pe203_hs[c] h[c] pi[c] cdpea[e] & pe_hs[e] & h[c] h[c] nadp[c] & & lgnc[e] na1[e] h[c] pi[c] h[c] pcholhep_hs[c] pcholhep_hs[e] lac_L[e] nad[c] lac_L[c] so3[c] gthox[c] h[c] h2o[c] nadph[c] nadp[c] octa[c] octa[e] adp[c] h2o[c] gly[e] thr_L[e] leu_L[e] phe_L[e] met_L[e] gln_L[e] ile_L[e] his_L[e] ala_L[e] ser_L[e] trp_L[e] cys_L[e] hom_L[e] lys_L[e] cl[c] h2o[c] lac_L[e] na1[c] nadh[c] nadp[c] h2o[c] h2o[c] nadph[c] & CE2243[c] lac_L[c] lac_L[e] CE0737[c] & nadph[c] h[c] nadp[c] dca[e] Rtotal2[c] pelinl_hs[c] h[e] atp[c] adp[c] CE1243[e] nadh[c] & focytC[m] nadp[c] acetone[e] coa[c] co2[c] & CE5304[c] nadph[c] CE1243[c] nadh[c] & & ficytC[m] h[c] o2[c] & amp[c] coa[c] nadph[c] pi[c] & h2o[c] & & HC02203[e] na1[e] gthrd[c] h[c] h[c] coa[c] M00019[c] atp[c] Rtotal2[c] & Rtotal2[c] & pi[c] h[c] HC00955[e] & HC01577[e] & & h[c] h[c] & nadh[c] coa[c] & coa[c] & & & h[c] & gthrd[c] tsul[c] pyr[c] lac_L[c] h[c] & h[e] h[c] crn[c] h[c] & ps_hs[c] Rtotal2[c] Rtotal2[c] & & Rtotal2[c] h[c] peole_hs[c] sphmyln181161_hs[c] sphmyln181161_hs[e] h[c] h2o[c] & nadph[c] & nadph[c] & h[e] h[c] & & h2o[e] atp[c] adp[c] h2o[c] nadph[c] ile_L[e] & 3ohodcoa[c] & CE2248[c] h[c] & & h2o[c] nadp[c] & & pa_hs[e] h[e] nad[c] nadp[c] nadph[c] Lcystin[c] h[c] c6crn[c] c6crn[e] od2coa[c] & h2o[c] h2o[c] h[c] nadp[c] h[c] cys_L[e] h[e] h[c] o2[c] tethex3[e] tetpent6[e] & lgnc[c] adp[c] h[c] & h2o[c] pi[c] h[c] glu_L[e] h2o[e] nadp[c] lac_L[c] leu_L[e] oaa[c] & nad[c] coa[c] ppi[c] coa[c] ttccoa[c] na1[c] atp[c] h2o[c] h2o[c] & & h[c] mthgxl[e] coa[c] 3hexdcrn[e] 3deccrn[e] h2o[c] nadp[c] h[c] h2o[c] h2o[c] peste_hs[e] & steeth[e] pchollinl_hs[c] pchollinl_hs[e] prostge2[c] HC02205[c] nadh[c] & acetone[c] coa[c] nadph[c] h2o[c] nadp[c] nadph[c] co2[c] hexc[e] & Rtotal2[c] atp[c] adp[c] & prostgh2[c] & prostgf2[c] & HC02207[c] slfcys[c] h[e] & & Pyruvate nadp[c] h2o[c] h[c] 3thexddcoacrn[e] h2o[c] h[c] amp[c] coa[c] h2o[c] nadph[c] ctp[c] HC02203[c] ile_L[c] h[c] h[c] coa[c] h[c] h2o[c] h2o[c] nadph[c] h[c] atp[c] & h2o[c] h2o[c] orn[c] na1[c] nad[c] Rtotal3coa[c] h[c] h[c] nadp[c] & nadp[c] & coa[c] h2o[c] arg_L[c] glu_L[c] & h[c] & 3ttetddcoacrn[e] nadp[c] nadph[c] crn[c] & atp[c] & & h2o[c] nadh[c] & tethex3[c] CE2242[c] CE2246[c] & CE2250[c] & arachcoa[c] ppi[c] dca[c] malcoa[c] h2o[c] sphmyln18115_hs[c] sphmyln18115_hs[e] pi[c] h[c] & HC01700[e] prostgd2[c] h[c] h2o[c] ser_L[e] nadh[c] nad[c] tethex3coa[c] & & & & arach[c] M01729[c] asp_L[e] na1[e] nadh[c] gthrd[c] crn[c] h2o[c] coa[c] coa[c] h[c] pa_hs[c] & cdpdag_hs[c] pa_hs[e] co2[e] HC02201[e] nad[c] & acac[e] & h[c] crn[c] tetpent6[c] & tetpent6coa[c] & tettet6coa[c] & tettet6[c] amp[c] h2o[e] h2o[c] atp[c] adp[c] HC02200[e] HC02201[e] HC02199[e] HC02200[e] h[c] CE1556[e] 12ppd_R[c] 12ppd_R[e] 3hexdcrn[c] 3deccrn[c] nadph[c] h[c] coa[c] malcoa[c] h2o[c] h[c] & atp[c] atp[c] pe_hs[c] h[c] leu_L[e] HC02199[e] gthrd[e] gthrd[e] HC02199[e] & & lald_D[c] h2o[c] ppi[c] atp[c] na1[c] na1[e] ppi[c] coa[c] pi[c] h[c] gthrd[e] HC02199[e] h2o[c] gthrd[e] HC02201[e] ala_L[e] k[c] acac[e] lgt_S[c] & & coa[c] & atp[c] amp[c] o2[c] amp[c] coa[c] h[c] nadph[c] hexc[c] h[c] & & HC02201[e] HC02200[e] HC02199[e] & na1[e] hxcoa[e] hxcoa[c] caproic[c] amp[c] coa[c] coa[c] crn[c] crn[c] atp[c] & lgnc[c] ppi[c] pe13_hs[e] & trideceth[e] & gthrd[e] HC02199[e] HC02200[e] HC02200[e] HC02201[e] gthrd[e] slfcys[e] acac[c] na1[c] HC00591[c] & 3thexddcoacrn[c] elaidcrn[c] & elaidcrn[e] nadp[c] amp[c] ttccoa[c] & nadp[c] h2o[c] adp[c] atp[c] adp[c] pcholmyr_hs[c] pcholmyr_hs[e] nadh[c] pyr[e] nad[c] h[c] nadp[c] coa[c] ppi[c] & h[c] & ppi[c] h[c] atp[c] & coa[c] pi[c] h[c] alpa_hs[c] & h[e] gthrd[e] hco3[e] hco3[e] hco3[e] HC02200[e] na1[e] h[c] akg[e] h[c] amp[c] ppi[c] pe12_hs[c] pe_hs[e] HC02201[e] HC02199[e] HC02201[e] hco3[e] hco3[e] hco3[e] h[e] asn_L[e] acac[c] lac_L[e] nadph[c] nadph[c] nad[c] & coa[c] h2o[c] coa[c] coa[c] crn[c] pi[c] Rtotal2[c] coa[c] h[c] atp[c] & hco3[e] hco3[e] hco3[e] hco3[e] atp[c] hco3[e] hco3[e] hco3[e] h2o[c] h2o[c] & ala_L[c] amp[c] ppi[c] atp[c] coa[c] crn[c] atp[c] coa[c] ppi[c] & coa[c] CE2245[c] malcoa[c] & ahdt[e] & HC01361[e] hco3[e] hco3[e] hco3[e] hco3[e] hco3[e] hco3[e] nadph[c] pyr[c] h2o[c] atp[c] coa[c] crn[c] & 3ttetddcoacrn[c] coa[c] ppi[c] atp[c] coa[c] & amp[c] nadph[c] etha[c] sphmyln18114_hs[c] sphmyln18114_hs[e] h2o[c] hco3[e] & hco3[e] hco3[e] & & & & & & mal_L[c] pyr[e] & h[c] & amp[c] coa[c] coa[c] crn[c] amp[c] coa[c] h[c] & h2o[c] lnlccoa[c] pi[c] h[c] hco3[e] hco3[e] HC02200[e] hco3[e] na1[e] & pyr[c] & o2[c] nadph[c] malcoa[c] coa[c] pchol_hs[e] adp[c] dag_hs[c] & & & & & hco3[e] ala_L[c] na1[e] ile_L[c] & & cit[e] ppa[c] lac_L[c] caproic[e] 3hexdcoa[c] Rtotal3crn[c] & atp[c] amp[c] co2[c] coa[c] malcoa[c] co2[c] h[c] chol[c] h2o[c] hco3[e] & & & & & & & hco3[c] & & & na1[e] co2[c] & & retn[c] ac[c] h2o[c] h[c] M03134[e] ppi[c] crn[c] tettet6crn[c] & & nadp[c] ser_L[c] pi[c] h[c] atp[c] adp[c] h2o[e] hco3[c] hco3[c] hco3[c] & & & hco3[c] & & hco3[c] & nad[c] icit[e] & o2[c] tetpent6crn[c] h2o[c] atp[c] docosac[c] h2o[c] h2o[c] adp[c] & atp[c] arg_L[c] ala_L[c] pi[e] & adp[c] & & & & h[c] na1[c] coa[c] M01724[c] & docoscoa[c] & h[c] hco3[c] hco3[c] hco3[c] hco3[c] & na1[c] akg[c] 2hb[c] 2hb[e] na1[e] na1[e] & M03117[e] 3hdcoa[c] occoa[c] & dcacoa[c] & ddcacoa[c] & Rtotal2[c] h2o[c] ser_L[c] co2[c] Rtotal2[c] h2o[c] atp[c] adp[c] tyr_L[c] phe_L[c] trp_L[c] gly[c] hom_L[c] val_L[c] na1[e] pro_L[c] asn_L[c] thr_L[c] ile_L[c] cys_L[c] ser_L[c] gln_L[c] met_L[c] & & hco3[e] hco3[c] hco3[c] hco3[c] ser_L[c] Alanine_aspartate ac[c] & arach[e] h2o[c] ppi[c] 3ohxccoa[c] ddca[c] & ddca[e] h[c] & hco3[c] & & hco3[c] hco3[c] hco3[c] & & & & crn[c] h[c] coa[c] 3ddcrn[c] 3ddcrn[e] nadh[c] h[c] h[c] coa[c] h[c] & & pcholn15_hs[c] pcholn15_hs[e] hco3[c] hco3[c] hco3[c] hco3[c] orn[e] h2o[c] & h[c] h[c] na1[c] & pyr[c] tetpent3coa[c] & tetpent3[c] 3thexddcoa[c] & & & h2o[c] coa[c] h[c] h2o[c] h[c] h[c] pi[c] hco3[c] hco3[c] na1[c] na1[c] ile_L[e] na1[e] na1[e] h[e] & amp[c] atp[c] h[c] pi[c] & & hco3[c] & HC02201[c] HC02201[c] hco3[c] HC02201[c] HC02201[c] hco3[c] k[e] nh4[c] hxa[c] coa[c] M03134[e] & malcoa[c] hexccoa[c] h[c] nadph[c] crn[c] h2o[c] adp[c] etha[c] sphmyln180241_hs[c] sphmyln180241_hs[e] hco3[c] HC02199[c] HC02200[c] nad[c] for[e] crn[c] crn[c] & h2o[c] crn[c] coa[c] ppi[c] & h2o[c] h[e] & na1[c] & na1[c] na1[c] & na1[c] & & cl[e] & & na1[c] & & na1[c] & na1[c] na1[c] HC01609[e] & cpppg1[e] hco3[c] HC02199[c] HC02199[c] HC02199[c] HC02199[c] HC02200[c] HC02201[c] for[c] nadh[c] na1[e] ppa[e] retn[e] ac[e] crn[c] atp[c] coa[c] pe_hs[e] & pepalm_hs[c] pepalm_hs[e] Rtotal2[c] h[c] gthrd[c] h[c] HC02200[c] gthrd[c] leu_L[c] & gthrd[c] h[c] & & & & pyr[e] lac_L[e] M02108[e] coa[c] nadp[c] & & co2[c] lpchol_hs[c] h2o[c] pi[c] h2o[c] pi[c] h[c] HC02201[c] gthrd[c] HC02200[c] HC02201[c] HC02200[c] gthrd[c] HC02199[c] HC02200[c] asp_L[c] & asn_L[c] & CE1556[c] & nh4[c] gln_L[c] h[c] 3ttetddcoa[c] co2[c] coa[c] & cholp[c] pi[c] h2o[c] gthrd[c] gthrd[c] Lcystin[e] nadp[c] & h2o[c] docosac[e] & glyc[c] pchol2linl_hs[c] h[e] HC02199[c] h2o[c] TCA & h2o[c] h2o[c] atp[c] amp[c] & pi[c] h2o[c] atp[c] & pi[c] h[c] atp[c] adp[c] gthrd[c] h[c] lac_D[c] nadph[c] nadp[c] & coa[c] & co2[e] HC02200[c] h2o[c] & lac_D[e] akg[c] crn[c] nadph[c] nadp[c] coa[c] coa[c] h[c] & h[c] na1[e] & & na1[e] & & na1[e] & & & na1[e] & cl[c] & na1[e] & & na1[e] & & na1[e] & & na1[e] & gln_L[c] ac[c] & h[c] na1[c] C01601[e] h[c] h[c] h2o[c] h[c] atp[c] atp[c] adp[c] & atp[c] ppi[c] & CE2253[c] & CE2249[c] adp[c] h2o[c] adp[c] atp[c] & & pchol2ole_hs[c] prostge2[e] amp[c] glu_L[c] & h[c] C01601[c] & M02616[c] chol[c] & h2o[c] etha[e] & h2o[c] pcholn1836_hs[c] pcholn1836_hs[e] prostgh2[e] prostgf2[e] HC02205[e] HC02207[e] nadp[c] 3hddcoa[c] 5ohhexa[c] h[c] M00049[c] M00783[c] c8crn[c] c10crn[c] h[c] h[c] & prostgd2[e] HC02203[e] h[e] ddeccrn[c] Rtotal[c] h[c] glyc2p[c] & glyc2p[e] h[c]& pi[c] h2o[c] Rtotal2[c] arg_L[e] ala_L[e] h[c] na1[c] h[c] & & retinal[e] retinal[c] tyr_L[e] phe_L[e] trp_L[e] gly[e] hom_L[e] val_L[e] na1[c] pro_L[e] asn_L[e] thr_L[e] ile_L[e] cys_L[e] ser_L[e] gln_L[e] met_L[e] na1[c] co2[c] coa[c] but[e] coa[c] atp[c] cmp[c] h2o[c] na1[c] & HC01434[c] h[c] adp[c] coa[c] ppi[c] acald[c] h[c] pi[c] h[c] hco3[e] & co2[e] & h[e] cmp[c] & pchol2palm_hs[c] ficytC[m] nadph[c] c8crn[e] h[c] h2o[c] dag_hs[e] dag_hs[c] adp[c] h[c] h2o[c] nadp[c] & g3pc[e] g3pc[c] nad[c] h2o[c] ahcys[c] pi[c] h[c] atp[c] adp[c] focytC[m] icit[c] & tetpent3crn[c] pi[c] adp[c] h[c] pi[c] nadh[c] h[e] h2o[e] cit[c] tetpent3[e] c10crn[e] & pchol2ste_hs[c] h[c] nadp[c] nadph[c] dca[e] ddeccrn[e] C01601[e] h2o[c] & dhap[c] atp[c] adp[c] & hxa[e] h[c] atp[c] h[c] & cdpea[c] & ethamp[c] & HC00718[c] pcholn183_hs[c] pcholn183_hs[e] h[x] & h2o[c] fad[c] nh4[c] h2o[c] h[c] h[c] co2[c] tetpent6[e] & Rtotal2[c] & h[x] c4crn[e] 5ohhexa[e] octa[e] tettet6[e] h[c] & pe13_hs[c] pe13_hs[e] fadh2[c] h[c] ppi[c] pcholar_hs[c] h2o[c] pi[c] pi[m] chol[c] nadph[c] & pi[c] h[c] & ps_hs[e] & etha[c] leu_L[c] M02909[e] & glyc3p[c] & ctp[c] h2o[c] amet[c] h2o[c] cdpea[c] ps_hs[c] & pcholeic_hs[c] pi[c] h[c] atp[c] adp[c] & & & h[c] Glycerophospholipid chsterol[c] cl[c] h[c] atp[c] adp[c] & & HC00342[e] & nadp[c] HC02057[c] h2o[c] & h2o[c] h[c] Rtotal2[c] pcholn19_hs[c] pcholn19_hs[e] c4crn[c] pi[c] na1[e] Rtotalcoa[c] nh4[e] pcholet_hs[c] his_L[e] h2o[c] na1[c] coa[c] sphmyln_hs[c] & myelin_hs[c] & nh4[c] & ps_hs[c] & ps_hs[e] h2o[c] ac[c] h[m] ethamp[e] oaa[c] & h[c] pi[c] & pcholdoc_hs[c] pi[c] h[c] cdpdag_hs[c] adp[c] alpa_hs[c] cl[e] HC00319[e] Rtotal2coa[c] sgalside_hs[c] h2o[c] h[c] h2o[c] atp[c] adp[c] & acald[e] acald[c] Rtotal2[c] pi[c] h[c] & & & pailar_hs[e] & pcholhep_hs[c] atp[c] adp[c] hco3[c] glyc3p[e] cmp[c] atp[c] h[c] pcholn201_hs[c] pcholn201_hs[e] cl[c] itacon[e] h[c] & amet[e] h[m] h[c] & adp[c] & pchollinl_hs[c] arg_L[c] val_L[c] pro_L[c] cys_L[c] phe_L[c] pgp_hs[c] h2o[c] h[c] dag_hs[c] crm_hs[c] prostge1[c] prostge1[e] h2o[c] met_L[c] gln_L[c] gly[c] tyr_L[c] leu_L[c] asn_L[c] ile_L[c] hom_L[c] pi[c] h2o[c] & pi[c] h[c] ala_L[c] ser_L[c] trp_L[c] thr_L[c] na1[e] atp[c] h2o[c] h[c] na1[e] h[e] pi[c] & sphmyln18114_hs[c] & Rtotal2[c] na1[c] hco3[e] hco3[c] atp[c] adp[c] na1[e] na1[c] CE5853[c] cmp[c] h2o[c] HC02051[c] na1[c] na1[c] na1[c] hco3[e] HC02201[e] coa[c] pailar_hs[c] & pail_hs[c]sphmyln18121_hs[e] pcholmyr_hs[c] h2o[c] na1[c] na1[c] h[c] HC02201[c] hco3[c] pa_hs[c] adp[c] & & pi[c] h[c] cl[e] & & & & & & & & & & & & HC00664[c] amet[c] ahcys[c] bz[c] h2o[c] adp[c] h[c] sphmyln18121_hs[c] & & & & & & & & & & & h2o[c] h[c] & pi[c] h2o[c] atp[c] pcholn203_hs[c] pcholn203_hs[e] h[c] h[c] crm_hs[c] atp[c] adp[c] Rtotal2[c] h[c] h2o[c] & dag_hs[c] & pcholn15_hs[c] udp[c] h2o[c] itp[c] ctp[c] & pi[c] sphmyln181221_hs[e] h2o[c] cl[c] & & & & h[e] coke[c] & egme[c] egme[e] adp[c] h[c] h2o[c] & h2o[c] h[c] & & & & & na1[e]& & & & & & band[c] & bandmt[c] gthrd[c] hco3[c] hco3[e] gthrd[e] glyc[e] pi[c] atp[c] sphmyln181221_hs[c] Rtotal2[c] prist[c] & prist[e] pi[c] h[c] na1[e] glyc[c] & pailpalm_hs[c] & na1[e] leuktrC4[e] leuktrC4[c] & & pcholn1836_hs[c] h[c] na1[c] na1[e] na1[e] na1[e] & h2o[c] h[c] h[c] & h[c] & & h2o[c] atp[c] adp[c] na1[c] na1[e] na1[c] h[c] & pglyc_hs[e] pglyc_hs[c] sphmyln18122_hs[e] sphmyln18122_hs[c] & pi[c] h[c] arg_L[e] val_L[e] pro_L[e] cys_L[e] gly[e] ala_L[e] ser_L[e] tyr_L[e] leu_L[e] h2o[e] & phe_L[e] met_L[e] gln_L[e] trp_L[e] asn_L[e] thr_L[e] ile_L[e] hom_L[e] leuktrE4[e] leuktrE4[c] & octdececoa[c] & pcholn183_hs[c] atp[c] adp[c] udpglcur[c] co2[c] & hco3[c] & h2o[c] atp[c] & & dag_hs[c] crm_hs[c] pcholn204_hs[c] pcholn204_hs[e] & cdpdag_hs[c] h2o[c] h[c] idp[c] cdp[c] & crn[c] & Rtotal2[c] HC02199[c] HC02199[e] & sphmyln180241_hs[c] glcur[c] fald[c] h2o[c] paps[c] pap[c] hco3[c] hco3[e] nadp[c] prgnlone[c] & prgnlone[e] h2o[c] & pcholn19_hs[c] pi[c] h[c] & & pailpalm_hs[e] gly[c] h[c] sphmyln1824_hs[c] & h2o[c] HC01180[c] & pi[c] h[c] atp[c] adp[c] CE1925[c] pcresol[c] & pcs[c] adp[c] h[c] h2o[c] thf[c] & mlthf[c] HC02200[c] glu_L[c] & cmp[c] pi[c] atp[c] & pcholn201_hs[c] HC02200[e] coa[c] h[c] glyc[e] dag_hs[c] crm_hs[c] atp[c] adp[c] hco3[c] hco3[e] q10h2[e] & 5eipenc[e] & & h2o[c] h[c] crn[c] crn[c] h2o[c] pchol_hs[c] h2o[c] h[c] pcholn205_hs[c] pcholn205_hs[e] h[c] glu_L[c] HC00342[c] crn[c] crn[c] crn[c] crn[m] crn[c] dag_hs[c] clpn_hs[c] & Rtotal2[c] his_L[c] cit[c] HC00342[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] h[c] h[c] R2coa_hs[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] crn[c] 4mptnl[e] h[c] octdececrn[c] nadph[c] tag_hs[e] tag_hs[c] sphmyln18123_hs[e] sphmyln18123_hs[c] & & CE1310[e] CE1310[c] hco3[e] h[c] h[c] icit[c] crn[c] thexdd[c] crn[c] hexdtr[e] & no2[c] cl[e] crn[c] & pcholn203_hs[c] prgnlones[c] prgnlones[e] adp[c] h2o[c] Nacasp[c] so4[c] so3[c] h[c] pi[c] h[c] & h[c] cit[c] & h[c] h2o[c] h[c] HC02201[c] hco3[c] hco3[e] HC02201[e] adp[c] so3[c] itacon[c] h[c] icit[c] 3octdeccrn[c] 3octdeccrn[e] sphmyln18115_hs[c] & h2o[c] h2o[c] q10h2[c] q10[c] 2mop[c] h[c] pi[c] co2[c] mal_L[c] oxa[c] glyald[c] coa[c] crm_hs[c] pcholn204_hs[c] pi[c] h[c] pi[c] h[c] lys_L[e] & CE7047[c] & CE5986[c] & h2o[c] dag_hs[c] & & akg[c] pi[c] adp[c] h[c] & & coa[c] HC00361[c] M03167[c] atp[c] pi[c] HC00319[c] icit[c] & & adp[c] h[c] atp[c] adp[c] atp[c] adp[c] hco3[c] h[c] & & & glyc_R[c] gthrd[e] gly[c] h2o[c] & & & & ptth[c] sphmyln181161_hs[c] h2o[c] Rtotal2[c] gthrd[c] hco3[e] glu_L[c] h2o[c] & & & & & & & & pi[c] & & nadh[c] h2o[c] & & & & & & pcholn205_hs[c] & & & & & & & & pi[c] Rtotal3coa[c]& & & ppp9[c] & ppp9[e] pcholn224_hs[c] pcholn224_hs[e] CE2211[c] & CE2211[e] & h[c] VitE & & crn[c] sphmyln18116_hs[c] & & & & & & & pi[c] h2o[c] atp[c] udp[c] adp[c] h2o[c] & leuktrC4[c] & leuktrD4[c] & & & & & & h2o[c] atp[c] gdp[c] leuktrF4[e] leuktrF4[c] CE5021[c] CE5022[c] & & & 3hodcoa[c] h[c] dag_hs[c] crm_hs[c] pi[c] h[c] & pi[c] & & & pcholn224_hs[c] h[c] & so4[c] h[m] & & & crn[m] & & coa[c] h[c] h2o[c] nad[c] & & h[m] crn[c] 4mptnl[c] octdececrn[m] ac[c] sphmyln18117_hs[c] & atp[c] adp[c] na1[e] ser_L[c] asn_L[c] hom_L[c] leu_L[c] tyr_L[c] trp_L[c] ala_L[c] gly[c] gln_L[c] his_L[c] phe_L[c] cys_L[c] pro_L[c] val_L[c] ile_L[c] h[c] & & h[c] & & & & crn[m] Bile acid synthesis M01080[m] M01077[m] h2o[c] pi[c] h[c] & nh4[c] HC02199[c] hco3[c] hco3[e] HC02199[e] yvite[e] yvite[c] & h[m] fad[m] crn[m] crn[m] Rtotal3[c] Rtotal2[c] & nadh[c] CE5643[c] & & & crn[m] crn[m] 5eipenc[c] h[m] h2o[c] dag_hs[c] h[c] h[c] & HC02201[e] crn[m] atp[c] glyb[m] h[c] & pcholn2254_hs[c] atp[c] adp[c] h[c] Miscellaneous gthrd[e] crn[m] crn[m] h[m] crn[m] crn[m] crn[m] h2o[c] sphmyln18118_hs[c] & nad[c] dhap[c] & & HC02201[e] HC02199[e] HC02199[e] & crn[m] crn[m] nadp[m] nadph[m] pheme[c] & pheme[e] & gthrd[e] crn[m] ak2lgchol_hs[c] & paf_hs[c] h2o[c] & & cl[e] & na1[c] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & & na1[c] & nadh[c] o2[c] tetpent3crn[m] h[m] crn[m] & h2o[c] & dag_hs[c] crm_hs[c] pcholn225_hs[c] h2o[c] & HC02200[e] HC02200[e] akg[m] h[m] & h[c] nadh[m] nadp[m] adp[c] h[c] h2o[c] & pcholn2254_hs[c] pcholn2254_hs[e] utp[c] atp[c] gtp[c] HC02200[c] hco3[c] hco3[e] hco3[e] asp_L[m] h[m] h[m] crn[m] crn[m] crn[m] & nadph[m]h[m] coa[c] pi[c] atp[c] sphmyln181181_hs[c] pi[c] h[c] HC02200[e] hco3[e] glu_L[m] crn[m] crn[m] crn[m] crn[m] crn[m] & h[c] adp[c] pi[c] nad[c] hco3[e] hco3[e] crn[m] hexdtr[c] nadph[m] atp[c] accoa[c] & h[c] & h2o[c] hco3[e] hco3[e] q10[m] h[m] hexdtr[c] h[m] coa[m] h2o[c] Rtotal2[c] atp[c] adp[c] h2o[c] h[c] h2o[c] hco3[e] dcmp[m] & & coa[c] cl[c] & na1[e] & na1[e] & na1[e] & & na1[e] & & na1[e] & na1[e] & & na1[e] & & na1[e] q10[e] CE5072[c] & pi[c] & sphmyln181201_hs[e] sphmyln181201_hs[c] pcholn226_hs[c] pi[c] h[c] && & hco3[e] CE1310[m] h2o[m] h[m] glyc[m] & & & & lac_D[m] & lgt_S[m] & h[m] o2[m] & atp[c] adp[c] glyald[c] 3pg[c] L2aadp6sa[c] h[c] hco3[c] & & C02712[m] nadp[m] glyald[m] Rtotal[c] pglyc_hs[c] & pglyc_hs[e] pcollg5hlys[c] C03681[c] hco3[c] & & nadph[m] 5eipenc[m] nadph[m] adp[c] dag_hs[c] crm_hs[c] e4p[c] s7p[c] s7p[c] & pi[m] so4[m] so3[m] coa[m] fadh2[m] prgnlone[m] & pcholn24_hs[c] na1[c] ser_L[e] asn_L[e] hom_L[e] leu_L[e] tyr_L[e] trp_L[e] ala_L[e] gly[e] gln_L[e] his_L[e] phe_L[e] cys_L[e] pro_L[e] val_L[e] ile_L[e] hco3[c] & akg[m] crn[m] CE4872[m] & thcholstoic[m] CE5166[m] cholcoar[m] h2o[m] & & & adp[c] hco3[c] hco3[c] hco3[c] pi[m] docohepcoa[m] & docosahexcoa[m] M00625[m] h[c] Rtotalcoa[c] & h2o[c] pcholn225_hs[c] pcholn225_hs[e] hco3[c] HC00342[m] h[m] fadh2[m] 4mptnl[m] crn[m] & nad[m] ak2lgchol_hs[e] paf_hs[e] mag_hs[e] sphmyln18120_hs[c] h[c] pi[c] h[c] na1[c] atp[c] HC02201[c] hco3[c] icit[m] tetpent6crn[m] coa[m] h2o[c] Rtotal2[c] h[m] h2o[m] coa[m] h[m] nad[m] nadh[m] o2[m] h2o[m] HC02199[c] HC02201[c] CE5643[e] tettet6coa[m] nad[m] atp[c] adp[c] q10h2[m] gthrd[m] & nadp[m] h2o[m] & pcholn261_hs[c] pcholn261_hs[e] h2o[c] & na1[e] h2o[c] pi[c] gthrd[c] HC02199[c] HC02200[c] h[m] h[m] dcsptn1crn[m] & pi[c] h[c] HC02200[c] gthrd[c] icit[m] icit[m] crn[m] & hpyr[m] & c226crn[m] strdnccrn[m] eicostetcrn[m] h[m] 3hodcoa[m] h2o2[m] h2o[m] mag_hs[c] & Rtotal2[c] Rtotal2[e] & Rtotal2coa[c] h2o[c] & adp[m] h[m] h[m] CE2251[m] arachcrn[m] M01724[m] h2o[m] h[m] cdpchol[c] pi[c] h[c] pcholn281_hs[c] peste_hs[c] peste_hs[e] atp[c] adp[c] CE5072[e] & h2o[m] nadp[m] M01079[m] nadp[m] & stcrn[m] CE4872[m] h[c] coa[c] ppi[c] atp[c] h[m] tetpent3coa[m] coa[m] M01076[m] adp[c] h[c] & glyald[e] q10[c] Vitamin E metabolism coa[m] co2[m] lald_L[m] accoa[m] h2o[c] Rtotal2[c] h2o[c] leuktrC4[e] leuktrD4[e] & & coa[m] & coa[m] coa[m] nadp[m] betald[m] dhap[m] ppi[c] h2o[c] atp[c] pcholn24_hs[c] pcholn24_hs[e] HC01668[c] & nadh[m] o2[m] o2[m] h[c] amp[c] & pi[c] h[c] lys_L[c] HC02121[c] HC00619[c] tettet6crn[m] & & & h[m] nadh[m] nadh[m] oaa[m] M02973[m] h2o[m] & h2o[m] nadh[m] cholcoads[m] & cholcoas[m] fadh2[m] glyc[c] sphmyln18120_hs[e] pcholn28_hs[c] icit[m] adrncrn[m] arachdcrn[m] tetpent6coa[m] & crn[m] & & 2docohexecoa[m] & ctp[c] & atp[c] adp[c] h2o[c] CE5854[c] atp[m] dlnlcgcrn[m] tmndnccrn[m] h[m] nadph[m] o2[m] glyc_R[m] pi[c] h[c] gln_L[c] o2[c] o2[c] dcyt[m] h[m] cit[m] & & & crn[m] nadh[m] nad[m] accoa[m] coa[m] fadh2[m] & h2o[m] h[m] & pcholole_hs[c] & & accoa[m] h[m] coa[m] & pcholste_hs[c] pcholste_hs[e] atp[c] adp[c] h2o[c] nad[c] nadh[c] nadph[c] nad[c] h[c] adp[c] clpndcrn[m] M02638[m] M01775[m] M00122[m] M00100[m] M01726[m] M01770[m] M00022[m] M00263[m] M00011[m] M00342[m] M00261[m] odecrn[m] c4crn[m] R group synthesis fadh2[m] h[c] & CE2442[m] fad[m] 5eipencoa[m] & h[m] & h[c] gcald[m] & coa[m] & CE4874[m] nadph[m] h2o[m] nadp[m] atp[m] h2o[c] Rtotal2[c] & udp[c] & & coa[c] ppi[c] adp[m] pi[m] & nadp[m] & h2o[c] dcdp[c] accoa[m] pep[m] coa[m] c226coa[m] nad[m] h[e] adprbp[e] pcholole_hs[c] pcholole_hs[e] & & h2o[m] nadp[m] fad[m] lnlncgcrn[m] lnlccrn[m] elaidcrn[m] stcoa[m] M00579[m] & nad[m] & pcholpalme_hs[c] pi[c] h[c] h[c] & & & crn[m] fadh2[m] h[m] clpn_hs[m] & ppi[c] amp[c] h[c] h[c] & & & coa[m] coa[m] & & accoa[m] HC01459[m] h2o[e] gthrd[c] & stcoa[c] dcdp[m] coa[m] h[m] coa[m] coa[m] coa[m] coa[m] coa[m] eicostetcoa[m] h2o[m] coa[m] h[m] nad[m] & nadp[m] nadph[m] M00746[m] fad[m] atp[c] nh4[c] h[c] atp[c] adp[c] & h[c] h[c] h[c] pmtcoa[c] dudp[c] & fad[m] & chol[e] nad[e] & ser_L[e] ile_L[e] pro_L[e] tyr_L[e] trp_L[e] ala_L[e] cl[c] phe_L[e] leu_L[e] hom_L[e] gly[e] ala_D[e] arg_L[e] h[c] h[c] nad[m] coa[m] coa[m] coa[m] h2o[m] h2o[m] nad[m] cl[e] nadp[e] & ncam[e] pcholpalm_hs[c] h2o[c] & & h[m] nadh[m] h2o[m] M00753[m] & pi[c] h[c] cit[m] oxa[m] cit[m] & coa[m] h2o[m] fad[m] h[c] & h[c] nadh[c] & & & HC00342[m] h[m] crn[m] & nadh[m] nad[m] nadh[m] 3octpencoa[m] & & thcholst[m] & cmp[m] h2o[c] Rtotal2[c] peole_hs[c] peole_hs[e] nad[c] nadp[c] dadp[c] dudp[m] crn[m] & fad[m] CE2247[m] h2o[m] nad[m] h2o[e] atp[c] adp[c] udpglcur[c] dttp[c] nadh[m] h[m] h[m] glu_L[c] amp[c] & mal_L[m] & & & & & & & & & & & & crn[m] nadph[m] nad[m] fad[m] & HC02201[c] HC02201[e] na1[e] & na1[e] & & na1[e] & & na1[e] & & na1[c] & & na1[e] & & na1[e] & & h[c] glcur[c] h2o[c] h2o[c] dttp[m] cys_L[m] co2[m] crn[m] h[m] h[m] glyc3p[m] pi[c] h2o[c] pcholste_hs[c] h2o[c] met_L[m] crn[m] accoa[m] h2o[m] M02637[m] lnlncacrn[m] & nadp[m] nadph[m] & gln_L[c] ppi[c] & fald[c] Sfglutth[c] nadh[m] & fad[m] c8crn[m] & coa[m] h[m] hco3[c] hco3[e] pi[c] h[c] pcholpalme_hs[c] pcholpalme_hs[e] amp[c] atp[c] nadh[c] crn[m] h[m] & & & & crn[m] crn[m] crn[m] crn[m] pmtcrn[m] Rtotal3crn[m] lneldccrn[m] 3thexddcoa[m] h2o[m] crn[m] o2[m] & cl[c] & CE1926[c] dadp[m] HC00319[m] & crn[m] crn[m] crn[m] & & & & adp[m] & dnad[c] nad[c] nadp[c] atp[c] adp[c] h[m] & coa[m] cholcoaone[m] adp[m] coa[c] & h2o[c] & & & & & & & & & & & & & & hdcoa[c] odecoa[c] & dlnlcgcoa[m] CE2441[m] hexdpencoa[m] o2[m] atp[m] adp[c] accoa[c] na1[c] na1[c] na1[c] na1[e] na1[c] na1[c] h[e] q10h2[c] & h[m] h[m] pi[c] atp[c] h[c] pi[c] h[c] elaidcrn[m] ttdcrn[m] & tdcoa[m] adrncoa[m] & arachdcoa[m] o2[m] accoa[m] & & & nadph[m] h[m] na1[c] atp[c] atp[c] & glyclt[m] gtp[m] gdp[m] M01729[m] but[m] hexdtr[m] h2o[c] h2o[c] pcholpalm_hs[c] pcholpalm_hs[e] ppcoa[c] ppa[c] dadp[c] o2[m] h2o2[m] fadh2[m] & & nadph[m] coa[m] & h[c] h[c] h2o[c] & atp[c] adp[c] dgdp[c] dgdp[m] clpndcoa[m] M00116[m] M01236[m] M00123[m] M00101[m] M00006[m] CE4843[m] M00023[m] CE4847[m] M00012[m] M00343[m] CE4854[m] M00020[m] & 2octpencoa[m] crn[m] h2o[c] pi[c] adp[c] h[e] pcholmyr_hs[e] HC00617[c] & nad[m] & & nadph[m] nadp[m] h[m] 3pg[m] h2o[c] ser_L[c] ile_L[c] pro_L[c] tyr_L[c] trp_L[c] ala_L[c] cl[e] phe_L[c] leu_L[c] hom_L[c] gly[c] ala_D[c] arg_L[c] nadp[m] nad[m] coa[m] coa[m] h[m] coa[m] crn[m] nadp[m] chol[m] 3pg[c] 3pg[e] & ppi[c] ppi[c] adprib[e] chsterol[e] h2o[c] & acrn[m] coa[m] h[m] coa[m] crn[m] o2[m] h[m] & & cmp[m] & ach[c] & chol[c] cholp[c] h2o[c] NAD & xolest2_hs[e] adp[m] Methionine and cysteine metabolism nadh[m] & dcsptn1coa[m] fadh2[m] stcoa[m] ach[e] & h[c] pi[c] h[c] M01238[c] M01238[e] nadph[c] nadp[c] pyr[c] atp[c] atp[m] h2o[m] coa[m] coa[m] h2o2[m] h2o[m] ahcys[m] & ncam[e] & pcholole_hs[e] h[e] h[c] atp[m] h2o2[m] h[m] nad[m] o2[m] h[m] ctp[m] h[m] & atp[c] adp[c] adp[c] coa[m] ppcoa[m] coa[m] ppi[m] 3pg[c] hco3[c] hco3[e] & adp[c] h[c] & C5-branched dibasic acid metabolism h2o[m] h2o[m] h2o[m] h2o[m] h2o[m] h2o[m] h2o[m] crn[m] & tmndnccoa[m] & coa[m] CE2243[m] nadph[m] h2o[m] h2o[m] co2[m] amet[m] h[m] h2o[m] atp[c] & h[e] h[c] & h[m] & fadh2[m] fad[m] fad[m] coa[m] fadh2[m] h[m] h[m] h[m] adprib[c] h[c] pi[c] h[m] & nadph[m] h[m] h2o[c] h[c] amp[c] h2o[c] & pcholpalme_hs[e] & h2o[c] CE4888[c] & CE5665[c] h2o[m] h2o[m] & h2o[m] HC02199[c] HC02199[e] & nh4[c] pelinl_hs[c] pelinl_hs[e] atp[c] coa[c] amp[c] ppi[c] & & & & h[m] & crn[m] nadph[m] M02977[m] cdpdag_hs[m] ac[c] atp[c] chsterol[e] h2o[c] nad[c] h[c]nadh[c] nadph[m] & h2o[m] nadh[m] & pa_hs[m] & & h[c] h[c] xolest2_hs[e] & & nad[m] & crn[m] CE4795[m] & CE5116[m] CE5114[m] nad[m] nad[m] accoa[m] & docoscoa[m] M00606[m] cholcoa[m] & cholate[m] ps_hs[m] & pe_hs[m] & pchol_hs[m] & & oaa[e] & oaa[c] pppi[c] & h[c] & fadh2[m] fad[m] h[m] h[c] ahcys[c] & pcholpalm_hs[e] h2o[c] & ppi[c] fad[m] fad[m] coa[m] accoa[m] & h2o[m] lnlncacoa[m] od2coa[m] & CE2248[m] xoltriol[m] & xoltetrol[m] hco3[c] hco3[e] & nmn[c] 2mop[c] & HC00900[c] atp[c] dadp[c] dadp[m] glx[m] fad[m] fad[m] fad[m] fad[m] nadh[m] fad[m] M00742[m] pglyc_hs[m] & adp[c] h[c] & pi[c] h[c] gln_L[e] Rtotal3[c] & Rtotal3coa[c] atp[m] nad[m] o2[m] pgp_hs[m] h[c] amp[c] & & nad[m] accoa[m] coa[m] & nadh[m] fad[m] HC02200[c] h2o[c] na1[c] na1[e] pep[c] fad[m] & & & & & & & & & & & crn[m] h2o[m] & 2decdicoa[m] nadp[m] o2[m] HC02200[e] & quln[c] & pcholste_hs[e] atp[c] adp[c] & so4[m] & nadph[m] & coa[m] coa[m] coa[m] coa[m] nad[m] nadp[m] crn[m] h[m] coa[m] fadh2[m] & xol27oh[m] ppi[c] adprbp[c] adprbp[e] datp[c] dadp[m] itacon[m] citmcoa_L[m] coa[m] coa[m] nad[m] nadp[m] h2o[m] atp[c] chsterol[e] xolest2_hs[e] & Glyoxylate and dicarboxylate metabolism itaccoa[m] & M00127[m] M00129[m] coa[m] h2o[m] h2o[m] accoa[m] Glycerophospholipid metabolism h[c] ppi[c] & orn[c] adp[c] datp[m] h2o[m] coa[m] pi[m] & h2o[m] coa[m] h[m] pi[m] h2o[m] & amet[c] co2[c] h[c] M03051[c] M03051[e] xol7aone[c] xol7aone[e] acald[m] & & h[m] nadh[m] & & pchol2linl_hs[e] HC00250[e] nad[m] nad[m] nad[m] nad[m] fad[m] coa[m] lnlncgcoa[m] lnlccoa[m] fadh2[m] fad[m] r1p[c] & coa[m] nad[m] nad[m] nad[m] ppi[m] coa[m] fad[m] h2o[m] & & & & atp[c] coa[c] amp[c] ppi[c] accoa[m] nadh[m] hco3[c] hco3[e] HC01842[c] nicrnt[e] nicrnt[c] prpp[c] atp[c] h2o[c] na1[c] na1[e] h[c]nadph[c] h[c]so4[c] h[m] strdnccoa[m] & 4hexdtetcoa[m] & nadp[m] fadh2[m] coa[c] & h2o[c] adp[m] nadh[m] & CE2440[m] crn[c] na1[e] & pchol2ole_hs[e] pi[c] h[c] nadp[c] atp[c] amp[m] & h2o[m] & nad[m] h2o[m] fadh2[m] h2o[m] gthrd[c] na1[c] h[c] nadh[m] nadh[m] nadh[m] nadh[m] nadh[m] nadh[m] h2o[m] Rtotal3coa[m] gthrd[e] h[c] h[c] ppi[c] nac[c] xolest2_hs[e] asn_L[m] h[m] atp[m] nadh[m] fadh2[m] fad[m] accoa[m] 3hexdtetcoa[m] 2hexdtetcoa[m] crtsl[m] octdececoa[m] ahcys[c] h[c] & pi[c] ncam[e] chsterol[e] atp[c] adp[c] xol7ah3[c] & xol7ah3[e] Rtotal[c] & Rtotalcoa[c] HC01501[c] & HC00250[c] dtdp[c] & lac_L[m] adp[m] Fatty acid synthesis & & 3octdece1coa[m] r1p[c] h2o[c] h[c]nadh[c] dgsn[e] & dtdp[m] h[m] fad[m] 3octdece1coa[c] & 3octdece1crn[c] 3octdece1crn[e] guln[c] & glcur[c] nad[c] h2o[m] gtp[m] gdp[m] h[m] h2o[m] nad[m] chol[e] & & rnam[c] & & pchol2palm_hs[e] & lys_L[e] thr_L[e] cys_L[e] leu_L[e] met_L[e] ala_L[e] gln_L[e] pro_L[e] phe_L[e] val_L[e] tyr_L[e] asn_L[e] gly[e] ser_L[e] trp_L[e] arg_L[e] h[m] h[m] & fadh2[m] accoa[m] h2o[m] adp[c] h2o[c] pi[c] na1[e] na1[c] crn[m] fadh2[m] h[m] h[m] coa[m] nad[m] fad[m] accoa[m] h2o[m] & & h[c] h[c] M00117[c] M00117[e] atp[m] h[m] h[m] fad[m] 3decdicoa[m] & nad[m] HC01522[c] & HC00460[c] HC00460[e] na1[e] ala_L[m] Pyruvate metabolism h[m] h[m] ncam[c] & ahcys[c] ahcys[e] h2o[c] & dcdp[c] dtmp[m] h[m] arachcoa[m] & nadp[m] & & & nadh[m] nad[m] coa[m] & pchol2ste_hs[e] pi[c] h[c] HC02194[e] HC02194[c] h2o[m] h[m] & amet[c] atp[c] nicrns[c] & & & na1[e] & & na1[e] & & na1[e] & na1[e] & na1[e] & & na1[e] & na1[e] & & na1[e] & & na1[e] & & adp[m] Nacasp[m] nad[m] & 3ohodcoa[m] CE2242[m] nadh[m] Steroid metabolism atp[c] coa[c] amp[c] ppi[c] & atp[m] h[m] 3sala[m] fadh2[m] fadh2[m] coa[m] fadh2[m] nadp[m] & nadph[m] pi[c] chsterol[e] xolest183_hs[e]xolest2_hs[e] atp[c] adp[c] nad[m] fadh2[m] fadh2[m] fadh2[m] fadh2[m] nadh[m] nadh[m] nadh[m] h[m] & amet[c] 1mncam[c] h2o[m] CE2439[m] coa[m] & h[m] hco3[c] hco3[e] & coa[m] pi[m] fadh2[m] & h2o[m] HC00718[c] & adp[c] mescon[m] nadh[m] & & o2[m] & dcdp[m] nadh[m] nadh[m] octe5coa[m] h[m] h2o[m] M02745[c] M02745[e] na1[c] na1[c] na1[c] & na1[c] & na1[c] na1[c] & na1[c] na1[c] na1[c] amet[c] h[c] ahcys[c] & adp[m] h[m] accoa[m] na1[e] na1[c] Rtotal2[c] & Rtotal2coa[c] h[c] HC02203[m] h[m] nad[m] h[m] h[m] & lpchol_hs[e] atp[c] h2o2[m] & mescoa[m] prostge2[m] nadh[m] & fad[m] nadph[m] h2o[c] gtp[c] na1[c] & nadh[m] fadh2[m] pi[c] h[c] & hco3[m] & co2[m] h[m] h[m] fad[m] nad[m] 11docrtsl[m] xolest181_hs[e] h2o[m] & nadh[m] CoA synthesis nadh[m] uchol[e] uchol[c] lys_L[c] thr_L[c] cys_L[c] leu_L[c] met_L[c] ala_L[c] gln_L[c] pro_L[c] phe_L[c] val_L[c] tyr_L[c] asn_L[c] gly[c] ser_L[c] trp_L[c] arg_L[c] & & chsterol[e] atp[c] adp[c] & dgmp[c] & dgsn[c] fadh2[m] CE4791[m] & CE4793[m] nad[m] nadph[m] coa[m] h2o[m] bgly[c] & CE2934[c] CE2934[e] Pyrimidine synthesis & 5tedtricoa[m] coa[m] h[m] coa[m] xolest204_hs[e] hco3[c] hco3[e] h2o[m] Eicosanoid metabolism & fadh2[m] dectricoa[m] coa[m] o2[m] h2o[m] h[m] & h2o[m] fad[m] aldstrn[c] aldstrn[e] CE2028[e] ptdca[c] & ptdca[e] fadh2[m] fad[m] pi[c] & & na1[c] na1[e] atp[c] & akg[m] gly[m] nadh[m] fad[m] chsterol[m] M00429[m] h2o[c] h[m] coa[m] & dpcoa[m] & crtstrn[m] pi[c] h[c] o2[m] nad[m] nad[m] & nadph[m] & pcholn15_hs[e] h2o[c] atp[m] 2mop[m] & & nad[m] coa[m] & pi[m] accoa[m] accoa[m] nad[m] xol7aone[m] atp[c] adp[c] ttdcrn[c] & ttdcrn[e] & o2[m] fol[e] xolest2_hs[e] atp[c] adp[c] atp[c] adp[c] h2o[m] ppi[m] h[m] chsterol[e] & orn[e] adp[c] so3[m] & h2o[m] ivcrn[e] na1[e] na1[c] h[m] h[m] nadph[m] h[c] akg[c] & pcholar_hs[e] M01197[c] M01197[e] gmp[c] & gdp[c] & & & nadh[m] so4[c] h[c] h[m] hco3[c] accoa[m] o2[m] oh1[c] thymd[m] & & nadh[m] h[c] h[e] h2o[c] tsul[e] & tsul[c] citr_L[c] h2o[e] h[m] fadh2[m] & & nadph[m] CE2028[c] h2o[c] na1[e] & pcholn183_hs[e] pi[c] h[c] trdox[c] glu_L[m] accoa[m] accoa[m] & & & trdrd[c] h2o[c] fad[m] & atp[m] adp[m] & & & adp[c]& h2o[c] phaccoa[c] & phacgly[c] phacgly[e] coa[m] h2o[m] nadh[m] fadh2[m] co2[c] atp[c] adp[c] na1[e] na1[c] nad[m] ivcrn[c] o2[c] chsterol[e] xolest2_hs[e] bgly[e] dgdp[c] fadh2[m] fad[m] fadh2[m] nadh[m] so4[e] pchol_hs[e] dad_2[e] & din[e] Nucleotide Interconversion and Salvage Pathway dad_2[e] & nad[m] coa[m] 2dodtricoa[m] 3dodtricoa[m] h[m] h2o[m] nadh[m] & h[c] & hco3[e] na1[c] gly[c] h2o[m] nadh[m] & h[m] coa[c] succ[e] & succ[c] ac[m] accoa[m] & pcholn1836_hs[e] hpdca[c] & hpdca[e] atp[c] h[m] h[m] Fatty acid oxidation & CE2437[m] & CE2438[m] fad[m] h2o[m] nadp[m] & coa[c] h[e] thym[m] & 56dthm[m] Glycolysis/gluconeogenesis coa[m] fadh2[m] h[m] 4mop[c] oh1[e] h2o[e] pi[c] atp[c] h2o[c] nh4[e] na1[e] & & glu_L[m] h[m] 4mop[e] akg[e] nadph[c] na1[e] na1[c] na1[c] dgdp[c] accoa[m] nad[m] nadp[c] pi[c] h[c] so4[e] & nadp[m] & & pcholn19_hs[e] arg_L[e] met_L[e] trp_L[e] cys_L[e] asn_L[e] phe_L[e] val_L[e] ser_L[e] his_L[e] tyr_L[e] gln_L[e] pro_L[e] ala_L[e] thr_L[e] leu_L[e] gly[e] lys_L[e] dgdp[m] nadh[m] fadh2[m] h2o[m] coa[m] & accoa[m] 3hpp[e] h[c] & & 3hpp[c] & glu_L[c] atp[c] adp[c] & crn[c] glu_L[c] glu_L[c] h[c] h[c] stcrn[e] stcrn[c] dad_2[c] & nadp[m] h2o[m] h[m] Leucine nadh[c] h2o[c] glu_L[c] chsterol[e] xolest2_hs[e] & nadh[m] fad[m] accoa[m] & nad[m] fol[c] nad[c] & nadh[m] h[m] o2[m] 20ahchsterol[m] & ivcoa[c] & M00003[c] M00003[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] na1[e] h[m] co2[m] o2[m] dhf[c] 5dhf[c] 6dhf[c] & & & & & & & & & & & & & & & & h2o[e] pi[c] na1[e] pi[c] nad[m] nad[m] & & ptth[m] & pan4p[m] & & & 7dhf[c] hco3[c] h[e] adp[m] h[m] h[m] & akg[c] & pcholn201_hs[e] cl[c] adp[c] & coa[m] nadh[m] nad[m] hexdtrcoa[m] & hco3[c] atp[c] adp[c] lnlncgcoa[m] & accoa[m] aldstrn[m] & 11docrtstrn[m] & pi[c] pi[c] atp[c] pi[c] cmp[e] & cytd[e] na1[e] h[m] na1[e] h[c] atp[c] atp[c] adp[c] dcdp[c] & cytd[m] occoa[m] ile_L[e] adp[c] adp[c] adp[c] & pcholn204_hs[e] na1[c] dcdp[m] 3m4hpga[m] pail45p_hs[m] h2o[m] btcoa[m] coa[m] nadh[m] h[c] nadp[c] nadph[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] na1[c] & & & nadh[m] fadh2[m] fad[m] acleu_L[c] acleu_L[e] na1[c] & & dgtp[c] atp[m] CE2250[m] & nad[m] h2o[m] h[m] h2o[m] nad[m] xol7ah2[m] leu_L[c] & leu_L[e] xolest2_hs[e] pi[e] 3snpyr[m] akg[m] atp[m] ppi[m] h2o[m] nadh[m] h2o2[m] nadph[m] h[c] & adp[c] & coa[m] amp[m] accoa[m] chsterol[e] h2o[m] & coa[m] hxa[m] fadh2[m] & dec47dicoa[m] arg_L[c] met_L[c] trp_L[c] cys_L[c] asn_L[c] phe_L[c] val_L[c] ser_L[c] his_L[c] tyr_L[c] gln_L[c] pro_L[c] ala_L[c] thr_L[c] leu_L[c] gly[c] lys_L[c] & & atp[c] adp[c] pyr[m] adp[m] ile_L[c] & atp[c] atp[m] h2o[m] q10[m] hexe3coa[m] h[m] atp[c] & & & & pcholn205_hs[e] hco3[e] hco3[c] na1[c] h[c] h[c] & & & nadp[m] h[m] accoa[m] coa[m] & 3ivcoa[c] & 3ivcrn[c] 3ivcrn[e] dump[c] & dudp[c] & nadp[m] & h2o[e] h2o[c] pmtcoa[m] dopa[c] dopa[e] cl[e] hco3[e] hco3[e] na1[c] h[m] coa[m] h[m] o2[m] crn[c] & pcholn224_hs[e] h[m] & h[m] 3hivac[e] coa[c] nadph[c] 7dhf[e] & 6dhf[e] & 5dhf[e] & dhf[e] idp[e] & imp[e] adp[c] Alanine and aspartate metabolism tdcoa[m] 3hivac[c] nadp[c] zn2[e] zn2[c] HC02201[e] & HC02201[c] h2o[c] & adp[m] h[m] atp[m] & & nadp[m] nadh[m] nad[m] h2o[m] coa[m] fad[m] & & h[c] datp[c] dadp[c] h2o[m] & h[m] h[m] fadh2[m] h[m] h2o[m] pi[m] coa[m] & nadh[m] h2o[e] chsterol[e] xolest2_hs[e] h2o[c] dudp[c] dudp[m] atp[m] pi[m] fad[m] 3mglutac[c] & 3mglutr[c] pi[e] pi[c] & coa[m] accoa[m] h2o[m] nadh[m] nadp[m] nadph[m] h2o[e] h2o[e] damp[c] && dadp[c] & datp[c] nadh[m] nadph[m] & hco3[e] hco3[c] h[e] & h2o[m] nadh[m] & h[m] fadh2[m] fad[m] nad[m] nad[m] h[m] nadh[c] glu_L[e] glu_L[e] glu_L[e] & citr_L[e] dctp[c] dctp[m] & hco3[m] h2o[m] coa[m] h[m] aacoa[m] h[m] nadh[m] h2o[m] nadp[m] & h[m] pcholn225_hs[e] 3mox4hoxm[m] CE5101[m] fadh2[m] nadph[m] & & fad[m] accoa[m] nadph[m] & atp[c] adp[c] adp[c] & coa[m] nad[m] & h2o[m] fadh2[m] h[m] nadh[m] h[m]coa[m] nad[m] xol7ah2al[m] h2o[m] dhcholestanate[m] dopa[c] dopa[e] so4[c] & aps[c] paps[c] atp[c] dcdp[c] h[m] & & h2o[c] udp[e] & dcdp[m] h[m] 3hexdcoa[m] nad[m] 4hexdtricoa[m] & 2octdectecoa[m] 3octdectecoa[m] & eitetcoa[m] & 2docopencoa[m] 3docopencoa[m] & docohexcoa[m] & dcsptn1coa[m] xol7ah3[m] & pcholn2254_hs[e] HC02200[e] & HC02200[c] h[c] cmp[m] adp[m] h[m] accoa[m] fadh2[m] fad[m] coa[m] h[m] h[c] 7thf[e] & 6thf[e] & 5thf[e] & thf[e] atp[c] ppi[c] h[c] h[m] & HC01408[m] & fad[m] & accoa[m] nadh[m] h2o[m] fadh2[m] thexdd[m] fadh2[m] lnlncgcoa[m] & fadh2[m] h2o[m] fad[m] h[m] coa[m] nad[m] & & pi[e] atp[c] & & fad[m] accoa[m] atp[m] h[c] h2o[e] adp[c] h2o[c] coa[m] Arachidonic acid metabolism fad[m] h2o[m] odecrn[m] acetone[e] hco3[e] hco3[c] 34dhmald[m] cit[m] & nadh[m] & nad[m] nadp[m] nadph[m] 3mglutac[e] 3mglutr[e] pydx5p[e] pydx5p[c] Phosphatidylinositol phosphate metabolism q10h2[m] fadh2[m] h[m] dece3coa[m] nadh[m] hco3[m] xolest2_hs[e] adp[c] adp[m] nadh[m] nad[m] fadh2[m] coa[m] accoa[m] nadph[m] nadp[m] & gsn[e] h2o[m] & adp[c] pi[c] pi[c] chsterol[e] dopa[c] dopa[e] gdp[e] amp[e] nadp[m] nh4[m] HC01415[m] 3ttetddcoa[m] 2hexdtricoa[m] nadph[m] coa[m] h2o[m] CE2421[m] & CE0713[m] & CE0849[m] & CE2433[m] & CE2418[m] & CE2422[m] & & o2[m] & h[c] pi[c] h[e] & & & & CE2084[m] h2o[m] coa[m] dc2coa[m] h[m] nadh[m] nad[m] & h[m] atp[c] glu_L[c] h[c] glu_L[c] h[c] HC02199[e] & HC02199[c] nadh[m] h[m] nadp[m] h[m] nadh[m] coa[m] nadph[m] h2o[m] h[c] 10fthf7glu[c] HC02216[e] HC02216[c] h[e] nad[m] h[m] nad[m] h2o[m] 3ocddcoa[m] nad[m] fad[m] CE2246[m] & & pcholn226_hs[e] datp[c] akg[m] h2o[m] o2[m] nadh[m] coa[m] h[m] h2o[m] & h[m] accoa[m] fadh2[m] accoa[m] & glu_L[c] h2o[c] pi[e] atp[c] dadp[c] h2o[m] & adp[c] pi[e] dadp[m] 3aib_D[m] accoa[m] glu_L[m] coa[m] & 3hexdtricoa[m] & hexdectecoa[m] & h[m] coa[m] h2o[m] o2[m] nadp[m] id3acald[m] & ind3ac[m] h[m] asnasnarg[c] phepheasn[c] thrasntyr[c] metasntyr[c] pheasnmet[c] asnpheasp[c] aspasnglu[c] gluasnleu[c] leuasnasp[c] asntyrthr[c] asntyrphe[c] asnmetpro[c] pi[e] h2o[e] h[m] h2o[m] fadh2[m] & h2o[m] nadh[m] pi[m] Propanoate metabolism h[m] h[c] & 5thf[c] & 6thf[c] & 7thf[c] h2o[c] Nucleotide interconversion & & coa[m] h2o[m] h[m] pi[c] hco3[c] hco3[e] h2o[e] nad[m] nadh[m] 3odcoa[m] h2o[m] accoa[m] fad[m] fadh2[m] fadh2[m] & h[c] & h[m] fadh2[m] nadph[m] h[m] & nadp[m] nad[m] h2o[m] h[m] atp[c] adp[c] & pcholn203_hs[e] HC02214[e] HC02214[c] & & & h2o[e] pi[e] & nadph[m] fadh2[m] & coa[m] nadh[m] fad[m] h2o[m] nadph[m] h[m] fad[m] nad[m] nadh[m] & ala_B[m] crn[m] & atp[c] adp[c] & & & trdrd[c] & asp_L[m] & h2o[m] & q10h2[m] fad[m] coa[m] nadh[m] fadh2[m] fadh2[m] co2[m] crn[c] crn[c] coa[c] gthrd[c] gthrd[e] & & & h[e] trdox[c] oaa[m] fadh2[m] fad[m] accoa[m] adp[m] & & & pi[e] & 2425dhvitd2[e] nadh[m] Pyrimidine catabolism HC00342[m] HC01407[m] h2o[m] h2o[m] nad[m] fad[m] M03168[m] & 3hpcoa[m] akg[m] atp[c] xolest2_hs[e] HC02216[e] & HC02216[c] & & h[e] nadp[c] nadph[c] 2425dhvitd2[c] h[m] & & CE5120[m] CE5118[m] CE5117[m] h[m] glu_L[m] glu_L[c] utp[e] ump[e] h[e] & h2o[c] HC01405[m] CE4790[m] CE5119[m] & CE2432[m] & CE0785[m] Beta-Alanine metabolism 3tetd7ecoa[c] & 3tetd7ecoacrn[c] 3tetd7ecoacrn[e] chsterol[e] met_L[c] h[e] CE7097[m] h[m] nad[m] & tetdecdicoa[m] & hexddcoa[m] & lnlccoa[m] & CE2434[m] & nadph[m] nadp[m] h2o[m] coa[m] nad[c] HC02210[e] HC02210[c] thr_L[c] atp[c] h2o[m] & & pi[e] h[c] dgsn[m] h[m] nad[m] h2o[m] & h[m] nad[m] h[m] 10fthf6glu[c] hco3[c] hco3[e] dctp[c] nadph[m] nadh[m] fad[m] coa[m] CE2424[m] & CE2417[m] h[m] h[m] & pcholn24_hs[e] accoa[m] thexddcoa[m] & h[m] nad[m] & & & h2o[e] h2o[e] && atp[m] h2o[m] h2o[m] h[m] 3hdeccoa[c] & 3hdececrn[c] 3hdececrn[e] gthrd[c] gthrd[e] h2o[e] & h2o[e] & 34dhoxmand[m] accoa[m] & adp[c] pi[e] & & & h2o[m] q10h2[m] q10[m] & nad[m] coa[m] nadh[m] coa[m] pi[c] HC02208[e] HC02208[c] arg_L[c] phe_L[c] thr_L[c] tyr_L[c] met_L[c] phe_L[c] asp_L[c] glu_L[c] leu_L[c] asp_L[c] tyr_L[c] phe_L[c] pro_L[c] atp[e] h2o[c] dgdp[c] crn[c] coa[c] & pcholn261_hs[e] HC02214[e] & HC02214[c] h2o[e] adp[c] dgdp[m] nad[m] fad[m] 3hdcoa[m] fad[m] nad[m] fad[m] h2o[m] & & o2[m] accoa[m] nadp[m] ppi[m] nad[m] adp[e] adn[e] nadh[m] & h[m] CE0693[m] & CE2420[m] CE4794[m] & CE4792[m] & coa[m] atp[m] nadh[m] co2[m] h[c] gtp[c] ctp[c] fad[m] h[m] h[m] dgtp[c] adp[c] atp[m] 2425dhvitd2[m] nadph[m] h[m] nadp[m] hx2coa[m] & hxcoa[m] crn[m] & h2o[m] h2o2[m] coa[m] nadh[m] crn[c] & xolest2_hs[e] adp[m] & & fadh2[m] o2[m] h2o2[m] nadh[m] nad[m] coa[c] Folate hco3[e] hco3[c] pi[e] Miscellaneous nad[m] & & & chsterol[e] gtp[e] gmp[e] & h[m] NAD metabolism h[m] nadph[m] nadp[m] coa[m] coa[m] nadh[m] nadh[m] nad[m] nadh[m] h2o[m] acac[m] & aacoa[m] coa[m] h[m] atp[c] 10fthf7glu[e] 10fthf6glu[e] 10fthf5glu[e] 10fthf[e] xolest_hs[e] xolest_hs[c] h[m] fadh2[m] nadp[m] & & h[m] & C05279[m] C05280[m] accoa[m] msa[m] & 3hpp[m] 3ocddcoa[c] & 3octdec2crn[c] 3octdec2crn[e] glu_L[c] srtn[c] srtn[e] & o2[m] & nadh[m] uri[e] & & fad[m] h2o[m] fad[m] h2o[e] h2o[e] h2o[e] & pcholn281_hs[e] amp[c] h2o[c] h2o[c] datp[m] o2[m] h2o[m] & & HC01406[m] q10[m] h2o[m] h[m] nadh[m] accoa[m] & HC02201[e] & HC02201[c] h2o2[m] 10fthf5glu[c] pi[c] adp[c] h[c] h[c] dutp[c] & accoa[m] coa[m] dd5ecoa[m] & tetd7ecoa[m] & amp[m] etfox[m] etfrd[m] crn[c] aa utp[c] atp[c] adp[m] 3mox4hpac[m] & nadph[m] co2[m] h[m] & C04805[m] nadh[m] fadh2[m] o2[m] & h[m] glu_L[c] glu_L[e] glu_L[e] glu_L[e] r5p[c] & adprib[c] adprib[e] atp[m] h2o[m] h2o[m] fadh2[m] & Cholesterol metabolism & atp[c] & pcholn28_hs[e] nadp[m] accoa[m] fadh2[m] h[c] h2o[m] co2[m] nad[m] dece4coa[m] & & & h2o[m] fadh2[m] & fad[m] crn[m] h2o[c] 5forthf[c] hco3[e] hco3[c] h2o[m] nadp[m] nadh[m] fad[m] accoa[m] nadh[m] fad[m] fadh2[m] & h[m] nadh[m] h2o[c] fad[m] nadph[m] co2[m] & chsterol[e] xolest2_hs[e] & nadph[m] q10[m] q10h2[m] dcacoa[m] fadh2[m] & coa[m] & & 3tetd7ecoa[m] & coa[m] pydx[e] pydx[c] srtn[c] srtn[e] nadp[m] nad[m] h[m] accoa[m] fad[m] fadh2[m] h[m] nadph[m] nadp[m] h[m] adp[m] h[m] accoa[m] crn[c] & & & nad[m] fad[m] h2o[m] pi[m] atp[m] & nh4[c] HC02200[e] & HC02200[c] & adp[m] & icit[m] fadh2[m] glu_L[m] & & nadp[m] h[m] & h[m] h2o[m] 3ddecdicoa[m] 2ddecdicoa[m] & dece4coa[m] & dec24dicoa[m] & nadh[m] h[m] nadh[m] nad[m] acetone[m] co2[m] akg[m] & acleu_L[m] & nadp[c] & pcholdoc_hs[e] & dgmp[m] h2o[m] nad[m] h[m] fadh2[m] h2o[m] coa[m] nad[m] crn[m] & nadph[c] pydxn[e] pydxn[c] nadh[m] accoa[m] duri[m] nadh[m] nad[m] nadh[m] nadh[m] h2o[m] coa[m] nad[m] h[m] accoa[m] h2o[m] h[m] nad[m] coa[m] q10[m] h[m] hco3[e] hco3[c] nadph[m] h[m] crn[m] nad[m] nadh[m] coa[m] h[m] accoa[m] nadh[m] h[c] dudp[c] 1a2425thvitd2[m] & ttetddcoa[m] nad[m] h2o[c] methf[c] & mlthf[c] & pcholeic_hs[e] & & lneldccoa[m] & nadh[m] coa[m] nad[m] fad[m] hmgcoa[m] & 3mgcoa[m] & 3mb2coa[m] & ivcoa[m] & 4mop[m] & leu_L[m] nadp[c] & srtn[c] srtn[e] h[m] & leuktrB4[m] h2o[m] coa[m] h[m] h2o[m] coa[m] nad[m] nad[m] fad[m] bhb[m] co2[c] pydam[e] pydam[c] provalgln[c] trpproval[c] dgtp[c] & dgtp[m] & CE4990[m] & accoa[m] h[m] pi[c] nadph[c] valprotrp[c] leuval[c] valleuphe[c] valphearg[c] argtyrval[c] vallystyr[c] trpvalasp[c] aspvalasn[c] & atp[m] & nadp[m] CE5944[m] & CE4988[m] accoa[m] fad[m] fadh2[m] nadh[m] fadh2[m] h2o[m] hco3[m] q10h2[m] adp[m] nadph[c] nadh[c] HC02199[e] & HC02199[c] tyrvalmet[c] argvalcys[c] valval[c] dudp[m] h[m] o2[m] h[m] nad[m] nadh[m] h[m] & h2o[m] & coa[m] dtdp[c] nad[m] tddedicoa[m] tddedi2coa[m] & tdec4ecoa[m] & ctdecdcoa[m] & dece3coa[m] & 10fthf6glu[m] h2o[c] xolest2_hs[e] & & & h[m] nadph[m] nadp[m] nadph[m] nadh[m] fad[m] fadh2[m] coa[m] h2o[m] & HC10857[m] & HC10858[m] & hdcoa[m] adp[c] h[c] glu_L[c] h[c] adp[c] nadh[c] nad[c] chsterol[e] & & & & h[m] pi[m] h[m] h[m] nad[m] nadh[m] h[m] fad[m] & fadh2[m] & pi[c] adp[c] pi[c] h[c] h[c] & & o2[m] h2o[m] & nad[m] nadph[m] h[m] & accoa[m] 3ivcoa[m] & h[m] atp[c] for[c] atp[c] progly[e] progly[c] & & & adp[m] homoval[m] co2[m] nadp[m] & h2o[m] fad[m] nadph[m] h[m] malcoa[m] coa[m] h2o[m] adp[m] & & & hco3[c] hco3[e] & & adp[c] dtdp[m] & h[m] nadh[m] & nadp[m] h2o[m] h[m] nadp[m] h2o[m] nadh[m] coa[m] & atp[c] nad[c] & pcholet_hs[e] & nadph[m] & odecoa[m] fad[m] crn[m] coa[m] accoa[m] & 3hivac[m] pi[m] 7thf[c] thf[c] 10fthf[c] & nadp[c] trp_L[c] met_L[c] nadp[m] o2[m] & fadh2[m] hdd2crn[m] fad[m] h[m] 10fthf7glu[m] & & gthrd[c] gthrd[e] cys_L[c] na1[e] & HC01434[m] nadph[m] glu_L[m] Folate metabolism pchol2palm_hs[c] pchol2palm_hs[e] dcdp[c] adp[m] & h[m] Leukotriene metabolism coa[m] ddcacoa[m] & & h[m] h[m] coa[m] atp[m] HC02210[e] & HC02210[c] & fadh2[m] h2o[e] h2o[c] 5fthf[c] 5mthf[c] & pcholhep_hs[e] dcyt[e] & & & HC10856[m] & 3mglutac[m] 10fthf5glu[m] & h2o[c] forglu[c] & & nadph[m] h[m] h2o[m] nadp[m] fadh2[m] nad[m] crn[m] & 6thf[m] glu_L[c] trp_L[c] pro_L[c] asp_L[c] nadp[m] h[m] nad[m] & fad[m] h[m] h2o[e] oh1[e] gln_L[c] pro_L[c] leu_L[c] phe_L[c] arg_L[c] tyr_L[c] lys_L[c] asn_L[c] tyr_L[c] arg_L[c] dcdp[m] h2o[m] nad[m] chsterol[e] xolest2_hs[e] hco3[c] hco3[e] coa[m] h[m] accoa[m] nad[m] coa[m] h2o[m] & thf[e] nwharg[e] nwharg[c] & h[m] mal_L[m] & h[m] coa[m] glu_L[m] co2[m] leuktrB4woh[m] nadh[m] fadh2[m] h2o[m] tdcoa[m] nad[m] nadh[m] h2o[m] amp[m] coa[m] h2o[m] gthrd[c] gthrd[e] na1[e] 1a25dhvitd3[e] dgmp[c] & CE5947[m] vacccoa[m] & vacccrn[m] nadh[m] h2o[m] fadh2[m] fad[m] h[m] & HC10859[m] 5thf[m] thf[c] & & & 1a25dhvitd3[c] h[m] nadh[m] & glu_L[c] h2o[c] & pchollinl_hs[e] nadp[m] nadph[m] nad[m] h2o[m] fad[m] nad[m] oh1[c] pcholn281_hs[c] pcholn281_hs[e] HC02208[e] & HC02208[c] & & q10[m] accoa[m] fad[m] M00885[m] & M01573[m] & M03022[m] & M01141[m] & M00849[m] & M00172[m] & M03019[m] & M01191[m] & crn[m] & o2[m] ppi[m] co2[m] h[m] & h[m] & dtmp[c] dump[m] h2o[m] nadh[m] h[m] crn[m] octd11ecoa[m] h2o[m] 10fthf[m] atp[m] & h[m] nad[m] nadph[m] nadp[m] & accoa[m] nad[m] h[m] crn[m] occoa[m] methf[m] 5fthf[e] 5mthf[e] hco3[e] hco3[c] h2o[c] trdox[c] & Citric acid cycle h2o[m] & coa[m] nadh[m] adp[c] 1a25dhvitd2[m] 25hvitd2[m] & & M03024[m] & 5fthf[m] h2o[m] pi[m] pcholn28_hs[c] pcholn28_hs[e] atp[c] adp[c] atp[c] trdrd[c] nh4[m] nadh[m] fad[m] fadh2[m] M00170[m] & M00841[m] & ppi[m] h[m] & pi[m] nrpphr[c] nrpphr[e] val_L[c] atp[c] na1[c] & h[m] nadh[m] h[m] fad[m] dcmp[e] & nadp[c] & nadph[m] CE2053[m] & leuktrB4wcooh[m] accoa[m] nad[m] adp[m] dcmp[c] dcdp[c] & dctp[c] dcyt[c] nadph[m] h[m] nadp[m] & M00843[m] h2o[m] HC02201[e] & HC02201[c] & & & adp[m] h2o[c] dgdp[m] h2o[m] adp[m] nadph[m] pi[m] q10h2[m] & 3ohdcoa[m] & & HC01397[m] & nad[m] pcollg5hlys[c] pcollg5hlys[e] pi[c] & & na1[c] h[c] dgdp[c] atp[m] h[m] nadp[m] fadh2[m] nadp[m] h[m] & nadph[m] h2o[c] h2o[c] nadp[m] nadph[m] & 7thf[m] h[c] adp[c] Vitamin D metabolism & coa[m] h2o[m] & & nadph[m] & M00702[m] & M03014[m] & M00018[m] & nadh[m] & h2o[m] h[m] hco3[e] hco3[c] atp[c] adp[c] & coa[m] & adp[c] o2[c] glu5p[m] & h[m] fadh2[m] h2o[m] nad[m] atp[c] h[m] nadh[m] nad[m] h2o[m] fadh2[m] fad[m] crn[m] q10h2[m] coa[m] coa[m] atp[m] pi[m] nadp[m] atp[m] pcreat[c] pcreat[e] nadph[c] atp[m] ctp[m] & q10[m] adp[m] for[m] nrpphr[c] nrpphr[e] dgtp[c] dgdp[c] & & & thymd[e] h[c] dadp[c] dadp[m] akg[m] 4h2oglt[m] glx[m] 3hddcoa[m] CE5144[m] & CE5148[m] & CE5150[m] & coa[m] crn[m] cmp[c] cdp[c] ctp[c] h[c] & & & & & & & pi[c] drib[e] glu_L[m] dd2coa[m] HC02200[e] & HC02200[c] dgtp[c] dgdp[c] pi[c] dcyt[c] drib[c] & & fad[m] fadh2[m] fad[m] fadh2[m] atp[m] & ocdececrn[m] & glylysphe[c] glyhislys[c] hisglylys[c] glytyrlys[c] asntyrgly[c] glyhisasn[c] glyvalhis[c] valarggly[c] metglyarg[c] argcysgly[c] glylyscys[c] trpglugly[c] atp[c] na1[e] h[m] h2o[m] 3oddcoa[m] fadh2[m] pcresol[c] pcresol[e] dcdp[c] nad[m] fad[m] coa[m] fad[m] & 5dhf[m] & 6dhf[m] dctp[c] & adp[c] o2[c] h2o[c] dcdp[c] dcdp[m] & & M01776[m] hco3[e] hco3[c] atp[m] nh4[m] & M02976[m] lpro[m] & & & & h2o[c] & atp[m] & & & gtp[c] gdp[c] dcmp[c] h2o[c] nadh[m] asp_L[m] pyr[m] nadh[m] h2o[m] coa[m] nadp[m] nadph[m] & adp[m] & & datp[c] dadp[c] cl[e] atp[c] 3uib[e] 25hvitd3[c] & 2425dhvitd3[c] & tre[e] tre[c] nrpphr[c] nrpphr[e] & & & & & fadh2[m] hdd2coa[m] nh4[m] nadh[m] & & & pi[c] 2dr1p[c] h2o[c] nadp[m] nh4[m] & nadh[m] h[m] nad[m] 3hdeccoa[m] h[m] nadph[m] h2o[m] HC02199[e] & HC02199[c] & h[c] h2o[c] adp[c] adp[m] h[m] Valine, leucine, and isoleucine metabolism pi[m] & ctp[c] cdp[c] na1[e] ala_B[e] h2o[c] & h2o[m] nad[m] & h2o[m] h[m] & pailste_hs[e] h[c] h[m] atp[m] 4hglusa[m] 3otdcoa[m] & h[m] & 2maacoa[m] & M03050[m] & M00897[m] & M00795[m] & co2[m] h[m] glu_L[c] utp[c] udp[c] nadph[c] nadph[m] & 3hmbcoa[m] nadh[m] nad[m] nh4[m] co2[m] arg_L[c] & h2o[c] nadp[c] glu5sa[m] 3htdcoa[m] dhlpro[m] nadp[m] chsterol[e] tmndnc[e] tmndnc[c] h[c] & o2[m] coa[m] h2o[m] fad[m] nad[m] & utp[c] adp[c] q10[m] & xolest2_hs[e] ppa[e] ppa[c] udp[c] h[c] na1[c] nadp[c] VitD & h[m] q10h2[m] coa[m] glu_L[m] fadh2[m] coa[m] h2o[m] nad[m] glu_L[m] gdp[c] pi[c] h[e] 1a25dhvitd3[m] & nh4[m] h2o[m] h[m]nadh[m] gtp[c] & & HC00591[m] & h[m] nad[m] HC01412[m] accoa[m] h2o[m] accoa[m] hdcea[m] nadph[c] o2[c] phe_L[c] lys_L[c] his_L[c] lys_L[c] tyr_L[c] asn_L[c] his_L[c] val_L[c] arg_L[c] met_L[c] cys_L[c] lys_L[c] trp_L[c] & akg[m] & fad[m] & tettet6[e] tettet6[c] lac_L[c] & lac_L[e] & pi[c] & nmn[m] & & & & fadh2[m] & mlthf[m] h[m] 7dhf[m] nadph[c] nadph[c] h[c] pail_hs[e] & pailar_hs[e] datp[c] dadp[c] & h[c] & 2425dhvitd3[e] cdp[m] ppi[m] nad[m] h[m] & 2oxoadp[m] crn[m] coa[m] alpro[m] nadp[c] nadp[c] nadp[c] nadp[c] nadp[c] h2o[c] adp[c] na1[c] adp[c] & h2o[m] M00069[m] & M00804[m] & nadp[c] nadph[c] nadph[c] nadph[c] nadph[c] nadp[c] nadph[c] o2[c] nadp[c] & dgdp[m] nadh[m] nad[m] coa[m] & & peole_hs[e] ctp[c] cdp[c] & h[c] dgdp[c] h[m] & h[m] CE5151[m] & M01777[m] & atp[c] & h2o[c] nadph[c] co2[m] dd3coa[m] nadh[m] accoa[m] & & & ppa[e] ppa[c] pi[c] h[c] 25hvitd3[e] & ala_L[m] oaa[m] & Tryptophan metabolism chsterol[e] xolest2_hs[e] chsterol[e] nh4[c] cl[c] atp[c] o2[c] & 25hvitd3[m] h2o[m] & coa[m] h2o[m] M00054[m] hdcecrn[m] HC01712[m] & M01068[c] & M00956[c] & M00960[c] & M00964[c] & M00967[c] & M00966[c] & M00954[c] & M00958[c] & M00962[c] h[c] h[c] nadh[c] nad[c] h2o[c] h[c] & pyr[m] nad[m] nadh[m] h2o[m] coa[m] & xolest2_hs[e] dctp[c] dcdp[c] atp[c] & L2aadp[m] thf[m] bhb[c] & bhb[e] nh4[c] nh4[c] vitd3[c] atp[m] h[m] & & dhf[m] h2o[c] & dudp[c] nadh[m] co2[m] nadh[m] h[m] fadh2[m] h[c] h[c] o2[c] h[c] h[c] pailpalm_hs[e] & peste_hs[e] whddca[e] whddca[c] & h2o[c] h[c] & nad[m] akg[m] accoa[m] accoa[m] thm[e] h[c] co2[c] h[c] nadp[c] & & thymd[c] & thym[c] & 56dthm[c] & 3uib[c] & 3aib_D[c] & nadph[m] CE5152[m] M00061[m] pyr[m] co2[c] h[c] h2o[c] h2o[c] o2[c] h2o[c] h2o[c] ppa[e] ppa[c] accoa[m] 1p3h5c[m] & & & M00909[m] coa[m] co2[m] 2oxoadp[m] o2[c] gly[c] atp[c] & & 2mbcoa[m] & 3mop[m] & ile_L[m] & acile_L[m] & pe2linl_hs[e] h2o[c] vitd3[e] datp[c] adp[m] & Glutamate metabolism h2o[m] e4hglu[m] & h[m] pi[c] ala_B[c] thymd[e] & adp[c] datp[m] nadp[m] nadh[m] h[m] nad[m] fad[m] nadh[m] nad[m] coa[m] h2o[m] nadh[m] coa[m] & & fol[m] h[c] h[c] dutp[c] nadp[c] co2[c] co2[m] h[m] & accoa[m] & atp[c] adp[c] but[c] & but[e] pi[c] na1[c] & h2o[m] h[m] h2o[m] 2mb2coa[m] & nad[m] glu_L[m] akg[m] fad[m] coa[m] h2o[m] fadh2[m] h[m] fad[m] HC00682[m] cytd[e] cytd[c] h[c] csn[c] csn[e] co2[c] nh4[c] na1[e] o2[m] h[m] fad[m] fadh2[m] h[m] co2[m] h[c] nadph[c] chsterol[e] xolest2_hs[e] h2o[c] & h2o[c] h[c] & nadph[m] coa[m] & h[m] coa[m] nad[m] & nadph[m] pi[c] adp[c] & h[c] na1[c] thym[e] adp[m] gln_L[m] h2o[m] h2o[m] nadh[m] nadh[m] & nad[m] fadh2[m] fadh2[m] glutcoa[m] coa[m] & h2o[c] na1[c] 7dhchsterol[c] h[m] nadh[m] nadph[m] ibcoa[m] & nh4[c] ts3[c] pd3[c] succoa[m] h2o[m] & coa[m] q10h2[m] q10[m] & M02612[m] nad[m] nadh[m] nadh[m] fad[m] nadp[m] phyQ[e] phyQ[c] h2o[c] h2o[c] nh4[c] na1[e] nadph[c] & Ubiquinone synthesis h2o[m] o2[m] fadh2[m] fad[m] h2o[m] fad[m] h2o[m] h2o[m] nadh[m] & o2[c] & pear_hs[e] for[c] for[e] na1[e] na1[c] h[c] na1[e] & & & nadph[c] h[c] h[c] h2o[c] 3hbcoa[m] b2coa[m] & glutcoa[m] & td2glutrcoa[m] nad[m] accoa[m] h[m] noncoa[m] fadh2[m] 2obut[m] nadph[c] nadp[c] nadph[c] & 2dr1p[c] pi[c] & h2o[m] & & & & & 3mob[m] h[c] avite1[c] avite1[e] & & dudp[c] dudp[m] & 1pyr5c[m] h[m] 2dpmhobq[m] 2dp6mobq_me[m] 2dp6mobq[m] hepcoa[m] pentcoa[m] 2mpdhl[m] & h[c] & pe203_hs[e] ac[e] & ac[c] & duri[c] duri[e] 3uib[c] h2o[e] h2o[m] & & co2[m] h[m] fad[m] h[m] & tiggly[m] crn[m] accoa[m] nadh[m] nad[m] & & & 3aib_D[e] pi[m] coa[m] & fadh2[m] coa[m] & & & na1[e] na1[c] r1p[c] 56dthm[e] Pyrimidin h2o[e] & cmp[m] nadp[m] 2425dhvitd3[m] nad[m] nadph[m] fadh2[m] coa[m] h[e] CE2313[c] CE2314[c] M00942[c] atp[c] adp[c] nh4[c] nadh[c] nad[c] h2o[c] & nadh[m] nad[m] nadp[m] nadph[m] ahcys[m] amet[m] h[m] o2[m] h2o[m] 2m3hbu[m] gly[m] h[m] coa[m] accoa[m] nad[m] accoa[m] accoa[m] h[m] co2[m] coa[m] 2mbcoa[m] nadh[c] co2[c] h[c] nad[c] h2o[c] CE5049[c] for[e] for[c] nh4[c] h[c] h2o[e] cdp[e] & cmp[e] h[m] o2[m] h[m] h[m] nadp[m] q10h2[m] q10[m] glutacoa[m] & & coa[m] & M00790[m] & nadh[m] h2o[m] nad[m] dhlam[m] h[c] nadp[c] nadph[c] nadp[c] h2o[c] nadph[c] nadp[c] o2[c] h[c] nadp[c] nadph[c] chsterol[e] xolest2_hs[e] alaargcys[c] alaarggly[c] alaglylys[c] alalysthr[c] tyrala[c] tyralaphe[c] argalaphe[c] argalathr[c] phelysala[c] alaasnleu[c] leualaarg[c] aspalaarg[c] h[c] h[e] dcdp[c] dcdp[m] gdp[m] Oxidative phosphorylation o2[m] h[m] & co2[m] h[c] h[c] for[c] h[c] pi[c] h[c] dgtp[e] & dgmp[e] nadph[m] nadh[m] nad[m] nadh[m] h2o[m] coa[m] fadh2[m] nad[m] accoa[m] & h[m] h2o[c] atp[c] nadp[c] & acglu[m] nadp[m] coa[m] 3mop[m] Miscellaneous h2o[c] uri[c] & ura[c] & 56dura[c] & cala[c] & cala[e] dhf[c] utp[e] & ump[e] pi[m] & h[m] fadh2[m] & h[m] h[c] & h2o[c] & pe226_hs[e] bhb[c] & bhb[e] & & dgtp[c] h2o[m] & M01165[m] & M00658[m] & 2dp6mep[m] undcoa[m] & tridcoa[m] & fad[m] fadh2[m] h[m] nh4[m] HC01376[m] 4mzym_int2[c] 4mzym_int1[c] & M00957[c] & M00961[c] & 44mzym[c] & 44mctr[c] h[c] & & & & & pi[c] na1[e] fum[m] gtp[m] & h[m] nadh[m] nadp[c] atp[c] pi[c] & & pi[e] ppi[e] & q10[m] h[m] h[m] fadh2[m] h2o[m] h2o[m] fadh2[m] fad[m] crn[m] coa[m] fad[m] fad[m] h[m] coa[m] fad[m] coa[m] h2o[m] & & lpam[c] & h2o[c] & & h2o[e] h[e] dtdp[c] fadh2[m] & adp[m] h[m] 4hpro_LT[m] M00873[m] & lpam[m] thmpp[c] & h[c] o2[c] & & pi[c] & na1[c] h2o[e] h[e] & & thm[c] & & & pe224_hs[e] for[e] for[c] h[c] ppi[e] h2o[e] dtdp[m] coa[m] h2o[m] co2[m] decdp[m] CE5153[m] & CE5154[m] & CE5155[m] & M01727[m] nad[m] ptdcacoa[m] & nadh[m] mlthf[m] o2[c] o2[c] h2o[c] nadph[c] thr_L[c] na1[c] nad[m] 3hglutcoa[m] nad[m] h[m] & amp[c] h[c] nadp[c] nadph[c] h2o[c] adp[c] nadp[c] na1[c] cl[c] cl[e] & dttp[e] & dtdp[e] h[e] ahcys[m] fad[m] nad[m] Thiamine metabolism atp[c] co2[c] nadph[c] h[c] h[c] thr_L[c] & na1[e] h[c] ctp[e] & cdp[e] cdp[c] h[m] fad[m] nadp[m] ahcys[m] h[m] Butanoate metabolism & nadh[m] M00780[m] & M00875[m] & ppcoa[m] h[m] nadh[m] atp[c] nadp[c] co2[c] h2o[c] o2[c] h2o[c] but[c] & but[e] nadph[c] atp[c] dtdp[e] & dtmp[e] atp[m] M00770[m] 3dpdhb_me[m] & & co2[m] coa[m] & & h[c] nadp[c] o2[c] h[c] chsterol[e] & & so3[m] h[m] & thmpp[m] h[c] nadp[c] xolest2_hs[e] & pi[c] pi[e] nadh[m] h[m] accoa[m] nadh[m] nad[m] h[c] pe12_hs[c] pe12_hs[e] na1[e] 56dura[e] & & coa[m] L2aadp6sa[c] coa[m] h2o[m] 3aib[m] thf[m] ivcoa[m] h2o[c] & for[c] & & ura[c] ppi[c] h[c] h[e] gdp[c] succ[m] pro_L[m] ppi[m] h[m] nad[m] & Thiamine C05109[c] M00940[c] M00938[c] & pedh203_hs[e] for[e] for[c] cys_L[c] arg_L[c] gly[c] lys_L[c] thr_L[c] tyr_L[c] phe_L[c] arg_L[c] thr_L[c] asn_L[c] itp[c] dutp[c] pi[e] accoa[m] akg[m] h[c] Cholesterol leu_L[c] arg_L[c] ura[e] mlthf[c] dgdp[c] pi[e] amet[m] nad[m] nadh[m] & & & coa[m] nadph[c] asp_L[c] gtp[c] & gdp[c] h[e] h[e] & & accoa[m] & & h[c] nadp[c] nadp[c] & atp[c] h2o[c] cyan[m] & tcynt[m] 3dphb[m] & 4hbz[m] h[m] h2o[m] fadh2[m] h[m] & HC00900[m] & nadph[c] nadp[c] nadph[c] nadp[c] pcs[c] pcs[e] adp[c] coa[m] na1[c] h2o[c] pi[c] nadph[c] o2[c] h[c] h[c] h[c] co2[c] h[c] pe_hs[e] acac[c] & acac[e] & & & ump[c] h[m] & & fad[m] na1[e] & & & adp[c] & h2o[c] h2o[c] h2o[c] h[c] o2[c] & nadp[c] sql[e] & pe12_hs[e] prpp[c] & o2[m] & & fad[m] glu_L[m] HC01377[m] h2o[m] o2[c] o2[c] h2o[c] & cytd[c] cmp[c] co2[m] & nad[m] nadh[m] mmcoa_S[m] h[m] nad[m] alpam[m] h2o[c] h[c] gtp[c] akg[m] succ[m] Biotin Metabolism M00046[m] & h[m] & co2[m] h[m] 4mop[m] h[m] dudp[c] & nadp[m] 4hbzcoa[m] & h[m]fadh2[m] accoa[m] crn[m] 2m3ovcoa[m] nadh[m] coa[m] HC02110[c] & M00963[c] & M00959[c] & M00955[c] & M01067[c] & zymst[c] chlstol[c] & ddsmsterol[c] & dsmsterol[c] dsmsterol[e] co2[c] & & nadph[m] amet[m] h2o[m] h[m] o2[m] coa[m] nad[m] h2o[m] h[c] nadph[c] chsterol[e] HC00319[c] HC00319[e] pyr[e] pyr[c] idp[c] h[c] & h[m] 3dpdhb[m] glutcon[m] h2o[m] & thmtp[c] & thmtp[e] nadp[c] xolest2_hs[e] atp[m] h[m] nh4[m] h2o[m] glu_L[m] L2aadp6sa[m] coa[m] accoa[m] nadh[m] accoa[m] & 2mop[m] & nadph[c] nadph[c] pi[c] prpp[c] ppi[c] h2o[m] h[m] amp[m] amp[m] coa[m] 3aib[e] & 3aib[c] pi[m] h2o[c] nadph[c] nadph[c] nadph[c] nadp[c] nadph[c] h[c] h[c] h[c] CE4796[m] & CE4808[m] h2o[e] nadp[c] nadp[c] nadp[c] nadph[c] nadp[c] nadph[c] h2o[c] nadph[c] h[c] bhb[c] & bhb[e] ala_L[c] cbp[c] q10h2[m] adp[c] dump[c] & & tsul[m] & & h2o[m] atp[m] h2o[m] M00778[m] M00887[m] & hpdcacoa[m] & nadh[m] acac[m] aacoa[m] Glycine, serine, alanine and threonine metabolism pi[c] h[c] atp[c] trdrd[c] Arginine and proline metabolism h2o[m] h[e] h[c] h2o[c] h[m] & & pe14_hs[e] pi[c] h2o[c] q10[m] trdox[c] atp[c] coa[m] Lysine metabolism lanost[c] Ssq23epx[c] & sql[c] & HC01118[c] atp[c] h[c] h[c] adp[c] ppi[c] & & fadh2[m] nadh[m] h[m] coa[m] thmmp[m] h[c] ppi[c] h[c] co2[c] h[c] h2o[c] & nadh[m] nadp[m] pi[m] mmcoa_R[m] & pyr[e] pyr[c] h2o[c] h[m] nadph[m] & nadh[m] h2o[m] h2o[m] M00877[m] & & M00063[m] succoa[m] & succ[m] & thmmp[c] & h[c] & pe13_hs[e] asp_L[c] & cbasp[c] & dhor_S[c] & nadph[m] h[m] btamp[m] fadh2[m] nadh[m] ppi[m] accoa[m] h[m] coa[m] o2[c] h[c] & orot[c] & orot5p[c] & ump[c] & udp[c] dcdp[m] h[m] & coa[m] thm[m] pi[c] h[c] ppi[c] nadp[c] HC02220[c] & HC02220[e] & dutp[m] & coucoa[m] & co2[m] M02611[m] fad[m] fad[m] & h2o[m] fad[m] h[m] nad[m] atp[m] amp[m] o2[c] nadph[c] h2o[c] o2[c] dcdp[c] adp[c] nad[m] focytC[m] h[m] & coa[m] fadh2[m] crn[m] for[c] & for[e] fadh2[m] etfrd[m] h[m] h[m] & Rtotalcoa[c] nadph[c] nadph[c] & & chsterol[e] ctp[c] adp[c] h2o[c] dutp[c] & nadh[m] succ[m] ROS detoxification nad[m] nadh[m] apoC_Lys[m] & apoC[m] & M00044[m] & M02052[m] accoa[m] fad[m] & & acgly[m] acgly[c] lanost[e] cdp[c] sucsal[m] h2o[m] & nad[m] & nad[m] & CE4807[m] & CE4802[m] & CE4804[m] & & 3hmp[m] bz[m] & bzcoa[m] h2o[e] xolest2_hs[e] h[c] adp[c] Heme synthesis h2o[m] coa[m] ppi[c] h2o[c] glu_L[e] h[c] adp[m] gdp[m] o2s[m] & h2o2[m] o2[m] h[m] adp[m] h[m] & apoC_Lys_btn[m] & coa[m] ppi[m] nadp[c] atp[c] ipdp[c] adp[c] pyr[e] pyr[c] h[c] & dadp[c] & gtp[m] ppi[m] coa[m] & ppi[m] nadh[m] nad[m] coa[m] co2[m] xolest2_hs[e] xolest2_hs[c] adp[c] pi[c] gdpfuc[c] accoa[m] & M02694[m] CE4803[m] & fadh2[m] h2o[m] Hippurate metabolism h[m] succoa[m] h[m] nadp[c] h2o[c] nadp[c] dmpp[c] ppi[c] & pe15_hs[e] na1[c] udp[c] & M03116[m] coa[m] fadh2[m] fad[m] coa[m] h[m] h2o[m] & h2o[c] h[c] & leusertrp[c] phesertrp[c] serphelys[c] serlyshis[c] sertrphis[c] trpsertyr[c] tyrargser[c] valserarg[c] thrserarg[c] serargtrp[c] cyssermet[c] serglyglu[c] utp[c] glu_L[m] h2o[m] hco3[m] Biotin metabolism crn[m] nadh[m] accoa[m] & na1[c] ppa[c] ppa[e] na1[c] pppg9[m] & ppp9[m] & nadh[m] amp[m] & cbp[m] nad[m] bgly[m] & h2o[c] pi[c] 3ohglutac[m] biocyt[m] h2o[m] CE4800[m] h[m] gly[m] HC01496[m] & chsterol[c] 5dpmev[c] & ipdp[c] & decdp[c] & & dadp[m] h[m] h[m] & h2o[c] grdp[c] & frdp[c] & & pe17_hs[e] & & & coa[m] Tyrosine metabolism h2o[m] nadp[m] M02051[m] & hpdececoa[m] coa[m] & CE4801[m] val_L[m] & 3mob[m] & ibcoa[m] & coa[c] M00937[c] & M00939[c] & & & pi[m] coa[m] coa[m] pheacgly[m] arach[c] & arach[e] & & gtp[c] gdp[c] & h2o[m] & & coa[m] nadh[m] & xolest2_hs[e] & & & cbasp[e] & h2o[m] nadh[m] Urea cycle h2o[m] akg[m] h[m] h[m] & & akg[m] & adp[c] & & atp[c] & dgdp[m] h[m] & coa[m] glu_L[m] coa[m] ipdp[c] ppi[c] & dgdp[c] & ahcys[m] nad[m] & nad[m] & thmmp[e] na1[e] akg[e] akg[c] orot5p[e] glu_L[c] o2[m] atp[m] h[m] pcreat[m] M00056[m] & M00797[m] & M00899[m] co2[m] h[m] 5aop[m] nadp[c] nadp[c] pi[c] chsterol[e] & & h2o[m] orn[m] M00806[m] crn[m] glu_L[m] phpyr[m] & acgly[e] o2[c] nadph[c] & co2[c] dmpp[c] thr_L[c] cys_L[c] glu_L[c] h[e] dctp[c] dcdp[c] adp[c] o2[m] h[m] nad[m] saccrp_L[m] & h2o[m] & akg[m] h2o[m] HC01223[m] phe_L[m] & atp[c] glu_L[c] h2o[c] & & & adp[m] & atp[m] & nad[m] succoa[m] acac[c] & acac[e] & & cbp[c] & h[m] atp[m] h2o[m] coa[m] xolest_hs[c] & pepalm_hs[e] atp[c] nad[m] h[m] T4hcinnm[m] 34hpl[m] & 34hpp[m] & atp[m] coa[m] nad[m] nadh[m] M01237[m] M00004[m] 2m3ovac[m] fad[m] co2[m] R2coa_hs[c] h[c] adp[c] & h[m] nadph[m] & h[m] & glcr[e] glcr[c] & & adp[m] & h2o[m] 3hibutcoa[m] & phaccoa[m] 3mb2coa[m] 5pmev[c] & dgtp[c] h2o[m] nadp[m] fadh2[m] h2o[m] & CE4806[m] & 3hmp[c] pac[m] & h[m] akg[e] akg[c] leu_L[c] trp_L[c] phe_L[c] lys_L[c] his_L[c] trp_L[c] tyr_L[c] arg_L[c] val_L[c] arg_L[c] trp_L[c] met_L[c] ser_L[c] dgdp[c] pi[c] h2o[m] h2o[m] h[m] h2o[m] h[m] 3h3mglt[c] 3h3mglt[e] & pe161_hs[e] orot[e] h[c] arg_L[m] nad[m] M00782[m] & M00048[m] h2o[m] q10[m] 2mbcoa[m] h[c] h2o[c] & & 4ohbut[m] h2o[m] h[m] citr_L[m] M00792[m] & h[m] accoa[m] coa[m] aact[c] nadph[c] o2[c] nadph[c] alaargcys[e] & alaargcys[c] cl[e] atp[c] & h[m] pi[m] & ppi[m] btn[m] & crn[m] atp[m] & & nadp[c] adp[c] for[c] & for[e] cl[c] fadh2[m] coa[m] coa[c] h[e] h[c] na1[e] & & glu_L[m] co2[m] aclys[m] & lys_L[m] & ppi[m] ivcoa[m] fadh2[m] chsterol[e] alaarggly[e] & alaarggly[c] & h2o[m] amp[m] & & h[c] xolest2_hs[e] datp[c] dadp[c] 4abut[m] nadh[m] nad[m] h2o[m] & & CE4799[m] coa[m] coa[m] & & 2aobut[m] & aact[m] zymstnl[c] lthstrl[c] & 7dhchsterol[c] vitd3[c] glutar[c] glutar[e] & adp[m] CE2176[m] h[m] & coa[m] fadh2[m] h[m] h[m] akg[e] akg[c] alaasnleu[e] & alaasnleu[c] & atp[c] atp[m] fe2[m] & & & coa[m] mlthf[m] & pelinl_hs[e] na1[e] atp[c] akg[m] h[m] amet[m] coa[m] accoa[m] fad[m] h[m] & crn[m] & nad[c] h[c] h[e] h[c] cit[m] & urea[m] fad[m] fad[m] coa[m] fadh2[m] h[m] & alaglylys[e] & alaglylys[c] utp[c] & hco3[e] h[m] Glutathione metabolism h[m] fadh2[m] h[m] & ser_L[m] co2[m] nadh[c] o2[c] h[c] h2o[c] h2o[c] & but[c] & but[e] & hco3[c] & h[m] his_L[m] nadh[m] coa[m] q10h2[m] & Phenylalanine metabolism coa[m] Purine catabolism nadh[m] accoa[m] HC01668[m] fadh2[m] fad[m] & thf[m] atp[c] ser_L[c] alahisala[e] & alahisala[c] & 3aib[e] h[m] CE4968[m] ibcoa[m] cl[e] cl[c] dcdp[m] so3[m] M00889[m] & M02107[m] dmnoncoa[m] & dmnoncrn[m] CE2026[m] h2o[c] h[c] coa[c] h[c] h[e] h[c] h2o[c] dcdp[c] so4[m] o2[m] & & M00071[m] h[c] h2o[c] akg[e] akg[c] alalysthr[e] & alalysthr[c] & akg[m] h[m] glypro[c] glypro[e] na1[c] na1[e] akg[m] & M00911[m] & M02616[m] ppiogly[m] h[m] fad[m] dudp[c] & h2o[m] h2o2[m] nad[m] h[m] ptdcacrn[m] & aact[e] mvlac[e] mvlac[c] & mev_R[c] & hmgcoa[c] & accoa[c] h2o[c] argalaala[e] & argalaala[c] akg[m] atp[m] bhb[c] & bhb[e] h[e] h[c] dudp[m] h[m] pheme[m] icit[m] M02103[m] M02102[m] akg[e] h[e] h[c] h[m] hpdcacrn[m] & ppa[m] & argalaphe[e] & argalaphe[c] dgdp[m] amp[m] h[m] HC00342[m] 3hmp[e] coa[m] nadp[c] coa[c] dgdp[c] h[m] gthox[m] & 3hbcoa_R[m] h[m] coa[m] hom_L[c] nadph[c] aacoa[c] & pi[m] h[m] coa[m] arg_L[m] his_L[m] hpdece[m] accoa[m] nadh[m] hom_L[m] akg[e] akg[c] argalathr[e] & argalathr[c] uri[e] & h2o[m] h[m] orn[m] coa[m] ppi[m] atp[m] coa[m] accoa[m] h[m] glutar[c] & glutar[e] h[e] h[c] gln_L[c] h[m] accoa[m] 2mp2coa[m] nad[m] coa[m] h[m] cit[m] gthrd[m] h[m] h[m] h[m] his_L[m] citr_L[m] h[m] h[m] orn[m] h[m] fad[m] nadph[m] argarg[e] & argarg[c] h[m] h[m] arg_L[m] pcrn[m] h2o[m] 2hb[c] & 2hb[e] glutrpala[c] trpargala[c] argvaltrp[c] thrilearg[c] tyrcysgly[c] trpglyasp[c] argvaltrp[c] lysvaltrp[c] trpleuval[c] rpmetval[c] trpalapro[c] glyphe[c] dtdp[c] dtdp[m] ppi[m] HC00342[m] accoa[m] creat[m] h[m] h[m] h[m] arg_L[m] h[m] CE2026[c] sarcs[m] fadh2[m] nad[m] nacvanala[m] orn[m] CE4970[m] CE4968[c] akg[c] argarglys[e] & argarglys[c] & & h2o[m] CE4969[m] hco3[c] h[e] h[c] utp[e] fum[m] etfox[m] h[m] nadp[m] h2o[m] & fad[m] h[m] tyr_L[m] 3ohglutac[c] nad[m] lac_L[e] lac_L[c] & & argargmet[e] & argargmet[c] & & crn[m] nadh[m] HC00900[c] bz[c] pacald[m] & & crn[m] & & & & & dadp[c] dadp[m] chsterols[e] & & argcysgly[e] & argcysgly[c] & so4[m] & & & so3[m] & & agm[m] & dmhptcoa[m] gd3_hs[m] cbl2[m] h2o[m] cysam[c] HC02220[e] & HC02220[c] bhb[c] & bhb[e] h[e] h[c] mal_L[m] & coa[m] & akg[e] na1[c] cys_L[c] asp_L[c] arg_L[c] leu_L[c] ala_L[c] argcysser[e] & argcysser[c] accoa[m] h[c] akg[m] acthr_L[m] cl[e] & h[m] h[m] akg[m] h2o[m] & & & gdpfuc[g] & pi[m] h[m] cl[c] accoa[m] lac_L[e] lac_L[c] arggluglu[e] arggluglu[c] h2o[c] pi[c] adp[c] ficytC[m] nadp[m] & & acile_L[c] crn[m] so4[e] pi[e] h[m] coa[m] CE4970[c] o2[c] hco3[e] h[e] h[c] h[c] & pi[m] & & nadph[m] crn[m] h[m] & so3[e] tsul[e] cl[e] argglupro[e] & argglupro[c] atp[c] pi[m] crn[m] & & & h2o[c] h[m] actyr[m] & crn[m] 2kmb[c] but[c] & but[e] & 35cgmp[e] adp[c] & & & h2o[m] & crn[m] crn[m] & h[m] h[c] hdd2crn[c] hdd2crn[e] argglygly[e] & argglygly[c] h2o[m] pi[m] h[m] & CE4798[m] CE4797[m] & cl[e] & glu_L[c] ala_L[c] arg_L[c] val_L[c] gly[c] gly[c] val_L[c] lys_L[c] val_L[c] pro_L[c] h[c] & & & & & h[c] cl[c] fald[m] chsterols[c] o2[c] h[c] for[c] pi[c] met_L[c] trpglyphe[c] h[e] h[c] & crn[m] coa[m] h[m] h[m] h[m] arghisthr[e] & arghisthr[c] h[m] fad[m] o2[c] h2o[c] nh4[c] & 35cgmp[c] & & & & crn[m] na1[c] h2o2[c] ac[e] ac[c] atp[m] & akg[c] & h[m] accoa[m] cl[c] & pap[c] h[c] argleuphe[e] & argleuphe[c] & pi[c] tsul[c] na1[e] na1[e] h2o[c] cys_L[c] fe2[c] fum[m] & & adp[c] & so4[c] so3[c] coa[m] & gp1c_hs[c] gp1c_hs[e] h[e] h[c] mal_L[m] & & & bz[e] 3sala[c] & hyptaur[c] & 4abutn[c] but[c] & but[e] arglysasp[e] & arglysasp[c] gtp[c] & q10h2[m] 2m3hbu[c] dmhptcrn[m] & thr_L[m] dmgly[m] adn[m] & pi[c] & & & 3ohglutac[e] & & & & h2o[c] o2[c] & Nucleotide metabolism h[c] & 5HPET[m] ptrc[m] & & h[m] CE2026[e] argphearg[e] & argphearg[c] & na1[c] & h[c] o2[c] h[c] ppi[c] & h[c] & & & crn[m] & bgly[c] & & o2[c] h2o[c] coa[c] ac[e] ac[c] h[e] h[c] nh4[c] nadph[c] ppi[c] h2o[c] h[c] actyr[c] & & h[c] acthr_L[c] na1[e] nad[c] trp_L[c] & na1[c] & & h[c] so4[c] nad[c] accoa[c] h[c] nadh[c] galam[e] galam[c] argpromet[e] argpromet[c] na1[e] & & & h[c] crn[c] & HC00900[e] o2[c] h2o[c] h[c] achom_L[m] achom_L[c] h[c] & nadp[c] & 2m3ovac[c] ppiogly[c] & & bhb[c] & bhb[e] argprothr[e] & argprothr[c] & & acile_L[e] & pheacgly[c] CE4970[e] CE4968[e] paps[c] co2[c] dkmpp[c] h2o[c] h[e] h[c] gmp[c] & h[c] & & h[c] ptrc[c] & aprut[c] & n4abutn[c] & & dgsn[e] 34hpl[c] arg_L[c] CE4969[c] 4aabutn[c] 4aabutn[e] h2o[e] argserser[e] & argserser[c] h[e] hpdece[c] h[i] nadh[c] orn[c] crn[c] h2o[c] h2o[c] h2o2[c] but[e] but[c] argtyrval[e] & argtyrval[c] amp[c] ppi[c] h[i] h[i] & na1[c] na1[e] h[c] ppi[c] h[i] & h2o[c] nh4[c] fmn[e] & ribflv[e] h[e] h[c] nh4[c] dgsn[c] fe2[e] & & 4ohbut[c] h[i] h[c] saccrp_L[c] & & atp[c] h[c] argvalcys[e] & argvalcys[c] atp[c] glutcon[c] crn[c] 2m3hbu[e] h[c] & & & bhb[c] & bhb[e] o2[c] & crn[c] & Lcyst[c] taur[c] & taur[e] pi[e] alahisala[c] hislysala[c] hisglnala[c] glnhishis[c] hismetgln[c] histrphis[c] hisglugln[c] cysgluhis[c] hisargcys[c] hiscyscys[c] asphiscys[c] glyphe[c] argvaltrp[e] & argvaltrp[c] xmp[e] h[c] pi[c] h2o2[c] nacvanala[c] agm[c] chsterol[c] h2o[e] h[e] h[c] sucsal[c] acglu[c] actyr[e] h[c] h[c] ipdp[c] h[e] & h2o[e] fum[c] akg[c] & h[c] ppi[c] nadh[e] h[c] asnasnarg[e] & asnasnarg[c] fum[c] h[c] & & h[c] h[c] ile_L[c] ile_L[e] 1a25dhvitd2[c] mal_L[c] so3[c] h[c] HC00342[c] h[c] h[c] atp[c] & h2o[c] nh4[c] h[c] his_L[c] h[c] citr_L[c] h[c] tiggly[c] crn[c] & M00241[e] & M00510[e] & & & mal_L[c] so4[c] h[c] akg[c] amet[c] h[c] crn[c] adp[c] & nad[e] & 5mdru1p[c] & & & asncyscys[e] & asncyscys[c] & itp[e] & idp[e] pi[c] so4[c] h[c] h[e] akg[c] crn[c] crn[c] crn[c] & & & 2dr1p[c] so3[c] arg_L[c] h[c] pi[c] frdp[c] ttc_ggdp[c] & & h[e] h[c] h[c] icit[c] pi[c] h2o[c] h[c] h[c] & citr_L[e] & citr_L[c] & & asnmetpro[e] & asnmetpro[c] Purine_cata h[c] cit[c] pi[c] 4hpro_LT[e] h[c] h[c] glutcon[e] his_L[c] arg_L[c] orn[c] h[c] pheacgly[e] acthr_L[e] ppiogly[e] CE4969[e] xmp[c] & gua[c] cit[c] HC00342[c] orn[c] saccrp_L[e] & & & hpdece[e] crn[c] & lcts[e] & HC01446[e] cl[c] cl[e] M01820[e] lys_L[c] ala_L[c] his_L[c] gln_L[c] arg_L[c] asp_L[c] val_L[c] acglu[e] 34hpl[e] akg[c] agm[e] ipdp[c] asnpheasp[e] & asnpheasp[c] h2o[e] nad[c] sucsal[e] h[c] nacvanala[e] achom_L[e] dmpp[c] ppi[c] Taurine and Hypotaurine na1[c] na1[e] atp[c] amp[c] prpp[c] pi[e] akg[c] & h[c] h[e] h[c] Purine_synth h[c] h[e] hom_L[c] hom_L[e] & h[e] 25hvitd2[c] asnphecys[e] asnphecys[c] h2o[c] adn[e] & gln_L[c] h[c] ins[e] atp[c] h[c] adp[c] h2o[c] tiggly[e] & & citr_L[e] & citr_L[c] asntyrgly[e] & asntyrgly[c] glu_L[c] h[c] nh4[c] h2o[c] pi[c] h[e] h[c] gua[e] 5mdr1p[c] ala_L[c] gln_L[c] gln_L[c] trp_L[c] glu_L[c] cys_L[c] cys_L[c] asn_L[c] & ppi[c] h[e] amet[c] & ametam[c] ametam[e] asntyrphe[e] asntyrphe[c] & nh4[e] ppi[c] h2o[c] & & glc_D[e] ade[c] & h[c] 7dhchol[c] & 7dhchol[e] thr_L[c] thr_L[e] asntyrthr[e] & asntyrthr[c] uri[c] & ump[c] & co2[c] h[e] h[c] atp[c] hco3[e] hco3[c] aspalaarg[e] & aspalaarg[c] & doldp_L[c] & amp[e] & prpp[e] dedoldp_L[c] & citr_L[e] & citr_L[c] gdp[c] & & aspasnglu[e] & aspasnglu[c] pi[c] gtp[c] & h[c] h2o[e] gal[e] h[e] h[c] h2o[c] adp[c] aspglu[e] & aspglu[c] pi[c] na1[c] na1[e] his_L[c] h[c] h[c] ppi[e] ade[e] val_L[c] val_L[e] pap[c] adp[c] 5mta[c] aspglupro[e] & aspglupro[c] h2o[c] pi[c] h[c] h[c] h[c] h[e] h[c] adn[c] amp[c] adn[c] amp[c] pi[c] atp[c] pi[c] h2o[c] paps[c] h2o[c] aspglutrp[e] & aspglutrp[c] chsterol[e] sucr[e] & atp[c] h[c] citr_L[e] & citr_L[c] tststerone[c] & tststerones[c] tststerones[e] h2o[c] nadh[c] gtp[c] & gdp[c] dgtp[c] & dgdp[c] 3hbcoa_R[c] na1[e] 2obut[c] adp[c] asphiscys[e] & asphiscys[c] gsn[e] co2[c] na1[c] pi[c] hexgly[e] & h[e] h[c] h2o[c] crn[c] nh4[c] h2o[c] & & na1[e] ptrc[e] & orn[e] na1[c] na1[e] & ala_L[c] ala_L[e] asphispro[e] & asphispro[c] h2o[c] h[c] asn_L[c] asn_L[e] h2o[e] cys_L[e] akg[c] h[c] phom[c] glyald[c] nadp[c] nadph[c] h[c] h[e] h[e] orn[c] ppa[e] & ppa[c] nad[c] thr_L[c] & fru[e] tststerone[e] hco3[c] 3dhdchol[c] & 3dhdchol[e] asplysglu[e] & asplysglu[c] & gluala[e] & pcreat[c] co2[e] urea[c] glutcoa[c] urcan[e] 2mb2coa[c] hco3[e] & cyscys[c] tyrcysthr[c] cystyrasn[c] cysasnmet[c] asnphecys[c] asncyscys[c] proasncys[c] proargcys[c] procys[c] cysaspphe[c] asnphecys[c] alltn[c] & C11821[c] ditp[e] pcrn[e] nadph[c] h[c] h2o[c] & cysleuthr[c] h[e] h[c] 25hvitd2[e] pi[c] o2s[c] o2s[e] ptdcacrn[c] pcrn[c] & akg[c] glu_L[c] thr_L[e] & fald[c] gal[e] pi[c] paps[c] pap[c] 5mta[e] nh4[c] hco3[e] hco3[c] citr_L[e] citr_L[c] asplyshis[e] & asplyshis[c] 4ohbut[e] pi[c] h2o[c] ile_L[c] h[c] crn[c] hmcarn[e] crn[c] coa[c] adp[c] HC02199[e] HC02199[c] pi[c] & na1[c] glyc3p[c] & ala_L[c] & 3mop[c] 3mop[e] atp[c] nadh[c] coa[c] atp[c] coa[c] hexgly[c] sarcs[c] ptrc[c] ptrc[e] na1[e] fum[e] crn[e] dhap[c] cgly[e] & gly[e] ile_L[c] amp[c] na1[e] h[c] na1[e] dhap[c] & h2o[c] & aspmetasp[e] & aspmetasp[c] 1a25dhvitd2[e] h[c] coa[c] adp[c] & coa[c] coa[c] dmhptcrn[c] ile_L[c] ile_L[e] na1[c] na1[e] na1[c] & subgly[e] & & ppi[c] urate[e] urea[e] adp[c] & dmnoncrn[c] & 3mob[c] 3mob[e] atp[c] glyald[c] h[c] & & & h[e] h[c] ind56qn[c] OxiPhosphoh[c] h[e] atp[c] orn[e] citr_L[e] h[c] val_L[c] atp[c] acald[c] hxcoa[c] h[c] na1[e] dedolp_L[c] dhea[c] & arg_L[e] & arg_L[c] & citr_L[c] na1[c] pro_L[c] pro_L[e] & & & & h2o2[c] nmn[c] & rnam[c] q10[m] ROS Detox M03117[c] & M03116[c] h[c] & & & & & aspprolys[e] aspprolys[c] & atp[c] amp[c] & na1[c] na1[e] orn[e] forglu[e] ca2[e] coa[c] h[c] nadh[c] na1[e] & nh4[c] pi[c] h2o[c] o2s[e] h[c] 3bcrn[c] h[c] ile_L[c] cl[c] cl[c] coa[c] & co2[c] hom_L[e] & hom_L[c] & h2o[c] & & nadph[c] nadp[c] met_L[c] phe_L[c] asp_L[c] na1[c] ppi[c] & h[c] coa[c] & & aspvalasn[e] & aspvalasn[c] na1[c] lac_L[c] co2[c] h[c] na1[e] cl[e] & urcan[c] c51crn[c] crn[c] nadh[c] nad[c] sbcoa[c] glyphe[e] na1[e] so4[c] & citr_L[e] citr_L[c] h[e] h[c] succ[c] & succoa[c] h[e] co2[c] & & coa[c] 4abut[c] amp[c] & coa[c] fna5moxam[e] ile_L[e] na1[c] h[e] HC00664[c] h[c] h2o[c] na1[e] & atp[c] h[c] adp[c] h[c] h[c] & h[c] glu_L[c] & 5oxpro[c] & 5oxpro[e] h[c] na1[c] glu_L[c] & 6hoxmelatn[e] atp[c] nadph[c] pi[c] cysasnmet[e] & cysasnmet[c] phelyspro[e] & phelyspro[c] & h2o[c] o2[c] h2o[c] gthrd[e] h2o[e] & na1[e] ppi[c] h2o[c] hco3[e] hco3[c] na1[c] h2o[c] h[e] h[c] o2[c] h2o[c] h[c] & h[e] & gly[c] & subgly[c] h[e] & h[c] h2o[c] ile_L[c] o2[c] h[c] no[c] no[e] gsn[c] alltn[c] & & coa[c] ppi[c] & c5dc[c] na1[c] nadh[c] nadp[c] adp[c] ile_L[e] o2[c] nwharg[c] cysaspphe[e] & cysaspphe[c] phephe[e] & phephe[c] & adp[c] & & ptrc[c] & na1[e] ptdcacoa[c] h[c] & & & & leu_L[c] leu_L[e] h[e] h[c] dimp[c] & ditp[c] ppi[c] & pi[c] pi[e] o2[e] cys_L[c] atp[c] orn[c] & & & & h2o[c] na1[c] & nadp[c] & h[c] h2o[c] pi[c] r1p[c] atp[c] & CE4888[c] na1[c] na1[c] h2o2[c] atp[c] nad[c] crn[c] dmgly[e] atp[c] cyscys[e] & cyscys[c] phepheasn[e] & phepheasn[c] h[c] h2o[e] & h2o2[e] & gthox[e] citr_L[c] ca2[c] & & & & adp[c] & 2hb[e] coa[c] dmgly[c] & & h[c] leu_L[c] thr_L[c] tyr_L[c] asn_L[c] asn_L[c] asn_L[c] pro_L[c] arg_L[c] pro_L[c] phe_L[c] asn_L[c] h[e] h[c] o2[c] ppi[c] & na1[e] Isoleucine amp[c] ppi[c] Valine 2hb[c] dheas[c] & dheas[e] h2o[c] nadph[c] nadp[c] 3dhlchol[c] & 3dhlchol[e] citr_L[e] & citr_L[c] & Glutathione h[c] crn[c] ile_L[c] nad[c] amet[c] atp[c] cysglnmet[e] & cysglnmet[c] phephethr[e] & phephethr[c] h2o[c] adp[c] h[c] h2o2[e] ile_L[e] na1[c] na1[c] ile_L[e] ppcoa[c] na1[e] & h[c] adp[c] h[c] na1[c] & Steroid h[e] h[c] & nh4[c] 2h3mv[c] na1[c] h[c] h2o[c] hco3[e] hco3[c] pi[c] nh4[c] h2o[c] gua[c] nad[c] nadh[c] h2o[c] adp[c] atp[c] coa[c] na1[c] cl[c] & hmcarn[c] cl[e] M03117[e] cl[e] cl[c] & cysgluhis[e] & cysgluhis[c] pheproarg[e] & pheproarg[c] h2o[c] & h[c] pi[c] h[e] 3bcrn[e] na1[e] acac[e] acac[c] glyphe[c] na1[c] pi[c] adp[c] r1p[c] h[c] lac_L[e] oh1[c] h2o[c] h2o2[e] & pi[c] & c51crn[e] cl[e] dmhptcrn[e] dmnoncoa[c] val_L[e] pi[c] met_L[c] h[c] h[e] h[c] h2o[c] h[c] h2o[c] glucys[c] creat[c] gudac[c] nadp[c] c5dc[e] forglu[c] & 4izp[c] 2hiv[c] ahcys[c] na1[c] cys_L[c] cys_L[e] cysglutrp[e] & cysglutrp[c] phesertrp[e] & phesertrp[c] h[c] asp_L[c] & na1[e] & pi[c] adp[c] akg[e] akg[c] & atp[c] h[c] xtsn[e] & h2o[c] nh4[c] ppi[c] & & h[c] h[e] h[c] xtsn[c] & & & crtn[c] 4abut[c] na1[e] & & tag1p_D[c] & xan[c] & urate[c] CE6252[c] CE0074[e] CE5025[e] & h2o[c] cgly[e] ahcys[c] h2o[c] atp[c] 6hoxmelatn[c] & ile_L[e] h[c] tagat_D[c] citr_L[e] & citr_L[c] cysleuthr[e] cysleuthr[c] phethrlys[e] & phethrlys[c] & & h2o[c] & CE5025[c] gthrd[c] & crn[c] & atp[c] h2o[e] 3htdcoa[c] cl[c] his_L[c] amet[c] h[c] ahcys[c] ile_L[e] coa[c] fna5moxam[c] & galt[c] galt[e] & h[e] h[c] & c4dc[c] crn[c] gln_L[c] cgly[e] h[c] thf[c] h[e] hcys_L[c] gal[c] & pi[c] HC02201[c] na1[c] na1[e] cys_L[c] atp[c] & na1[c] crn[c] h[c] sarcs[c] dedol_L[c] Galactose cyssermet[e] & cyssermet[c] phetrpleu[e] & phetrpleu[c] fpram[c] & air[c] prpp[c] h2o[c] no[c] atp[c] & h[c] co2[c] akg[c] h2o[c] h[e] h2o[c] na1[e] na1[c] ac[c] hco3[e] hco3[c] h[e] h[c] h[c] h[c] h2o2[c] C01041[c] ascb_L[c] pi[c] crn[c] amet[c] na1[c] h2o[c] h2o[c] & 2h3mv[e] ptdca[c] h2o[c] h[c] sarcs[c] ile_L[c] atp[c] h[c] xan[e] o2[c] & ile_L[e] gthrd[e] & glu_L[e] & & h[c] ppi[c] Propanoate glysar[e] & na1[e] glyb[e] & glyb[c] adp[c] h2o[c] hco3[c] cystyrasn[e] & cystyrasn[c] phetyr[e] & phetyr[c] pi[c] h2o2[c] dopa4glcur[e] dopa3glcur[e] 5cysdopa[e] 5cysdopa[c] & cys_L[c] na1[e] h[c] h[c] & glysar[c] dhea[e] andrstndn[c] h2o[c] atp[c] h[c] adp[c] pi[c] tyr_L[c] tyr_L[e] h2o[c] h[e] h[c] nadh[c] & didp[c] na1[c] pyr[c] & atp[c] & ppi[c] h[c] h[c] gly[e] nadph[c] pi[c] co2[c] urea[c] na1[e] nh4[c] akg[c] cys_L[c] & atp[c] na1[c] & nadp[c] amuco[c] & nadh[c] & hco3[e] glnasngln[e] & glnasngln[c] phetyrgln[e] & phetyrgln[c] adp[c] h2o[c] & nadp[c] nadph[c] & Urea cycle 5forthf[c] & na1[e] 3mhis[c] atp[c] tagat_D[e] f6p[c] h[e] h[c] h2o2[c] pi[c] adp[c] & ametam[c] 2hiv[e] h[c] nadph[c] citr_L[e] & citr_L[c] & glu_L[c] & HC00576[c] amp[c] h[c] HC02201[e] glnhishis[e] glnhishis[c] phetyrlys[e] & phetyrlys[c] & h[c] CE0074[c] atp[c] glu_L[c] h[e] coa[c] h[c] nadph[c] h[c] nadp[c] & nadp[c] HC02200[e] HC02200[c] h[e] h[c] & & succ[e] & adp[c] & ala_L[c] ala_D[c] & & & glu_L[c] o2[c] & & h2o[c] o2[c] & h2o[c] h[c] amp[c] amp[c] 4abut[c] 4tmeabutn[e] h[c] na1[e] cl[e] cl[c] na1[c] & 4pyrdx[c] & 4pyrdx[e] glnhislys[e] & glnhislys[c] proargasp[e] & proargasp[c] na1[c] h2o[c] h2o2[c] nadh[c] c4dc[e] na1[e] ile_L[e] his_L[e] h[e] h[c] h2o[c] ile_L[c] na1[e] coa[c] 3tdcrn[c] amp[c] & & & nadh[c] h[c] & & o2[c] phe_L[c] phe_L[e] hismet[c] methislys[c] trphismet[c] metphearg[c] metargleu[c] argpromet[c] argargmet[c] thrmetarg[c] thrtyrmet[c] aspmetasp[c] h[c] na1[e] pi[c] & na1[e] cl[e] h[c] h2o[c] trpmetarg[c] mettrpphe[c] glnlyslys[e] & glnlyslys[c] proargcys[e] & proargcys[c] nad[c] h2o[c] nad[c] CE5665[c] & 23dh1i56dio[c] h[c] gudac[e] h2o[c] pi[c] nadph[c] idp[c] h[e] h[c] ile_L[e] pi[c] coucoa[c] creat[e] h2o[c] h[c] argsuc[e] ppi[c] o2[c] h[c] h[c] nadph[c] h[e] h2o[c] atp[c] h[c] adp[c] pi[c] atp[c] pi[c] pi[c] Lcystin[e] orn[e] T4hcinnm[c] & ile_L[c] o2s[c] o2[c] h2o2[c] sarcs[e] & h2o[c] nadp[c] nadp[c] adp[c] h2o[e] glnlystrp[e] & glnlystrp[c] proasncys[e] & proasncys[c] gln_L[c] 2dr1p[c] 6hddopaqn[c] Glutamate glu_L[c] akg[c] na1[e] & ppcoa[c] & citr_L[e] & citr_L[c] h[e] h[c] 5aizc[c] & & gln_L[e] gln_L[c] gly[c] nadph[c] na1[c] akg[e] nadph[c] h2o[c] h2o[c] nadph[c] & & & ins[e] ins[c] & hxan[c] pi[c] adp[c] atp[c] coa[c] h[e] h[c] akg[c] o2[c] nad[c] h2o[c] nh4[c] dolichol_L[e] dolichol_L[c] & dolp_L[c] h[c] & & glnproglu[e] & glnproglu[c] procys[e] & procys[c] atp[c] gthrd[c] & na1[c] cgly[c] & gly[c] ppi[c] nad[c] h[c] o2[c] mlthf[c] nad[c] o2[c] pglyc_hs[e] Rtotal2[e] C05302[c] & C05302[e] & & fgam[c] & & so4[c] h[c] glucys[e] nad[c] h[c] & & & & h[e] h[c] asp_L[c] adp[c] nadh[c] h2o[c] h2o2[c] nh4[c] h2o[c] h[e] h[c] & dhea[c] & & glntrpglu[e] & glntrpglu[c] proglnpro[e] & proglnpro[c] r1p[c] & pi[c] h[c] h[c] o2[c] & na1[c] h2o[c] nadp[c] h[c] & cl[e] cl[c] trp_L[c] trp_L[e] lys_L[c] arg_L[c] trp_L[c] arg_L[c] leu_L[c] pro_L[c] hxan[e] na1[e] na1[c] nad[c] h2o[c] h[c] phe_L[e] na1[e] nadph[c] h2o[c] h2o[c] h[e] h[c] h[c] thf[c] na1[c] dopa4sf[e] & 3tdcrn[e] & 2oxoadp[e] & aact[c] & mthgxl[c] h[c] nad[c] 17ahprgstrn[e] & 17ahprgstrn[c] Triacylglycerol glntyrleu[e] & glntyrleu[c] proglulys[e] & proglulys[c] na1[e] CE2875[c] & CE2874[c] h[c] & h[c] h2o[c] nad[c] crtn[e] 2oxoadp[c] & L2aadp[c] & L2aadp6sa[c] & thp2c[c] h[c] & adp[c] ppi[c] nadp[c] & dadp[c] 1glyc_hs[e] & & & im4ac[e] im4ac[c] & im4act[c] & & oaa[c] betald[c] & chol[c] udpg[c] h[e] h[c] & pi[c] atp[c] udpglcur[c] & arg_L[c] argsuc[c] & ctp[c] pi[c] atp[c] o2[c] ac[c] citr_L[e] & citr_L[c] gluargleu[e] & gluargleu[c] prohis[e] & prohis[c] din[e] din[c] CE2870[c] h[c] atp[c] na1[e] 5mta[c] adp[c] & h[c] & & utp[c] cdp[c] h[c] glc_D[c] for[c] & for[e] & & & h2o[c] & pi[c] atp[c] Histidine & nadh[c] h2o[c] h[c] C10164[e] itp[c] h[e] h[c] & h2o[c] & fum[c] nadh[c] h2o[c] na1[c] Nacsertn[c] & melatn[c] C10164[c] am6sa[c] nadh[c] adp[c] h2o[c] nadph[c] h[c] gluasnleu[e] & gluasnleu[c] & h[c] 4hbz[e] h[c] h[c] & h2o[c] nadh[c] atp[c] prohistyr[e] prohistyr[c] h[c] adp[c] nh4[c] atp[c] o2[c] h2o2[c] 4glu56dihdind[e] atp[c] 13dampp[e] h2o[c] phe_L[c] gly[c] h[c] gal1p[c] & udpgal[c] h2o[c] h[c] nadh[c] h[e] h[c] 4glu56dihdind[c] & ile_L[c] nadh[c] nad[c] h2o[e] h2o[e] h2o[c] h[c] co2[c] & h[c] met_L[c] met_L[e] his_L[c] his_L[c] trp_L[c] phe_L[c] arg_L[c] arg_L[c] thr_L[c] tyr_L[c] asp_L[c] gluglu[e] & gluglu[c] adn[c] h[c] h2o[c] udp[c] h2o[c] Lcystin[c] h[e] h[c] nh4[e] h2o2[e] & & h[c] h[c] h[c] coa[c] 2m3ovac[c] pser_L[e] & adp[c] proleuarg[e] & proleuarg[c] adn[e] pi[c] nh4[c] na1[e] na1[c] h[c] nadh[c] h[c] & 5g2oxpt[c] 5g2oxpt[e] h[e] h[c] 25aics[c] & na1[c] na1[e] orn[c] glu_L[c] h2o[c] so4[c] ac[c] co2[c] na1[e] and19one[c] and19one[e] nad[c] h[c] 10fthf[c] h[c] & dopa4sf[c] hco3[c] nad[c] nadp[c] dolichol_U[c] & dolp_U[c] & & gluilelys[e] & gluilelys[c] prolyspro[e] & prolyspro[c] & h2o[c] h[c] ala_L[e] & spmd[e] & CE1939[e] adp[c] h[c] anth[e] citr_L[e] citr_L[c] h[e] h[c] h[c] his_L[c] ala_D[e] CE1940[e] HC02201[c] hco3[e] HC02201[e] na1[c] pi[c] atp[c] nad[c] kynate[e] so4[c] so4[e] coa[c] nad[c] nadh[c] adn[c] pi[c] 2dr1p[c] & na1[e] adpoh[e] adpoh[c] amet[c] & datp[c] atp[c] h[c] atp[c] h[c] adp[c] gluleu[e] & gluleu[c] prophe[e] & prophe[c] gar[c] adn[e] & pap[c] CE5629[c] CE5629[e] glu_L[e] triodthysuf[c] & HC02187[c] nadh[c] & spmd[c] leu_L[e] 3htmelys[c] & 4tmeabut[c] & 4tmeabutn[c] 5hoxindoa[e] h2o[c] 2mcit[c] N-Glycan udp[c] h[c] nadp[c] h[e] h[c] & h2o[c] dopa3glcur[c] & CE5586[c] h2o2[e] o2[e] o2[c] h2o[e] h[c] h2o[c] Lysine nh4[c] & h2o[c] pi[c] & pi[c] adp[c] nh4[e] & & thf[c] nadh[c] sbt_D[c] & fru[c] & f1p[c] ser_L[c] ser_L[e] glumet[e] glumet[c] proproarg[e] & proproarg[c] adp[c] & na1[c] na1[e] dad_2[e] dad_2[c] & ade[c] h[c] & akg[c] h[c] h2o[c] prgnlones[c] sbt_D[e] h[e] h[c] atp[c] h[c] 13dampp[c] & o2[e] leu_L[c] aclys[c] h[c] Gly_ser_ala_thr atp[c] & h[c] pi[c] & so4[c] h[c] & ala_B[e] accoa[c] hco3[c] hco3[e] & btn[e] succ[c] atp[c] h[c] adp[c] quln[e] & quln[c] akg[c] h[c] nad[c] h[c] adp[c] pi[c] 5HPET[c] & 5HPET[e] glumethis[e] glumethis[c] propropro[e] & propropro[c] r1p[c] h2o[c] gthrd[c] peplys[e] co2[c] pi[c] & glu_L[c] & h2o[e] fuc_L[e] met_L[c] h[e] h[c] h[c] h[c] & 4hbz[c] ametam[c] h2o2[e] gthrd[e] h2o[c] accoa[c] & nadh[c] nad[c] citr_L[e] & citr_L[c] pi[c] h[c] cl[e] 4hbzcoa[c] o2[e] nh4[e] h2o2[e] 3mhis[e] h[e] h[c] h[e] h[c] L2aadp[e] so4[c] h[c] fru[e] gluthr[e] & gluthr[c] protrplys[e] & protrplys[c] fum[c] h2o[c] na1[e] paps[c] h[c] na1[e] & ahcys[c] h2o[c] cmusa[c] h[c] & h[e] h[c] & & ade[c] ade[e] nh4[c] & h2o[e] nh4[e] & for[c] h2o[c] h2o[c] & na1[c] pap[c] so4[c] 34hpp[c] hista[e] hista[c] & h2o[c] akg[c] o2[c] & akg[e] pser_L[c] & 3php[c] & 3pg[c] Fructose and mannose gluthrlys[e] & gluthrlys[c] protrpthr[e] & protrpthr[c] prpp[c] CE2873[c] & CE2872[c] amp[c] & h[c] h2o[c] coa[c] accoa[c] & CE1943[e] & & 5htrp[e] s2l2fn2m2masn[e] & s2l2n2m2masn[e] na1[c] na1[e] atp[c] h[c] adp[c] h[e] h[c] ppi[c] h[c] & lys_L[e] & peplys[c] C02470[c] & 42A3HP24DB[c] h[c] udpg[c] 17ahprgnlone[e] & 17ahprgnlone[c] gln_L[c] gln_L[e] aicar[c] & cl[c] na1[e] srtn[e] C02470[e] h2o[c] pi[c] glutrpala[e] & glutrpala[c] provalgln[e] & provalgln[c] & h2o[c] paps[c] h[c] na1[c] & na1[c] na1[e] amet[c] & gthrd[c] h2o[c] pi[c] & dolglcp_L[c] h[e] h[c] gly[c] atp[c] & h[c] & ppi[c] h2o2[c] & CE1944[c] accoa[c] HC02199[c] hco3[e] HC02199[e] na1[c] atp[c] h2o[c] Ntmelys[c] & tmlys[c] so4[e] h2o[c] prpp[c] nh4[c] CE2866[c] atp[c] adp[c] hco3[c] na1[e] h2o[c] & & glyhisasn[e] & glyhisasn[c] serargala[e] & serargala[c] 10fthf[c] dopasf[c] o2[c] 5mta[c] & h2o[c] nad[c] h[c] h[c] h[c] pap[c] 7dhchsterol[c] & 7dhchsterol[e] citr_L[e] citr_L[c] h[e] h[c] h[c] pi[c] dopasf[e] & & h2o[c] dopaqn[c] h[c] pi[c] biocyt[e] & h[c] dhbpt[c] & adp[c] pi[m] co2[c] h2o[e] nh4[e] h2o[e] h2o2[e] & adp[c] h2o[e] thbpt[c] h2o[c] na1[c] & hco3[c] o2[c] h2o2[c] 2oxoadp[c] 2amac[c] & pyr[c] h2o[c] o2[c] glyhislys[e] & glyhislys[c] serargtrp[e] & serargtrp[c] h2o[c] ppi[c] & Biotin hco3[e] nformanth[c] & anth[c] & ser_L[c] nadph[c] nadp[c] h[e] h[c] pram[c] imp[e] & 4hphac[e] carn[c] & ala_B[c] & asp_L[c] sprm[c] lys_L[e] & lys_L[c] atp[c] h2o[c] h[c] kynate[c] 4aphdob[c] glu_L[c] adp[c] so4[c] so4[c] hxan[c] pi[c] h2o[c] sprm[e] HC02200[c] HC02200[e] ahcys[c] gthrd[e] 2mcit[e] & glylyscys[e] & glylyscys[c] sercysarg[e] & sercysarg[c] & CE1935[e] & CE1936[e] hco3[e] na1[c] h2o[c] atp[c] & h[c] h2o[c] ala_L[c] ala_L[e] h[e] h[c] ppi[c] glu_L[c] fum[c] dopa4glcur[c] & h[c] h2o[c] o2[c] & hco3[c] biocyt[c] o2[c] & 2m3hvac[c] pi[c] & thf[c] h2o[c] co2[c] L_dpchrm[c] & & btn[c] & btamp[c] h[c] & 5htrp[c] & srtn[c] & 5hoxindact[c] 5hoxindoa[c] nh4[c] paps[c] 7dhchsterol[c] 7dhchsterol[e] glntyrleu[c] phetyrgln[c] pheglnphe[c] thrglntyr[c] metglntyr[c] cysglnmet[c] glygly[c] proglnpro[c] trptyrgln[c] trpglngln[c] ileserarg[c] lysglnphe[c] glylysphe[e] & glylysphe[c] serglyglu[e] & serglyglu[c] h[c] dopaqn[c] h[c] h2o[c] ile_L[c] amp[c] & & h[c] h[c] ala_L[c] h2o[c] h2o[c] crtstrn[e] h2o[c] h2o[c] atp[c] adp[c] pi[c] h2o[c] h[c] o2[e] h2o2[e] nh4[e] 3mldz[c] & ile_L[e] h2o[c] M00213[c] glu_L[c] glu_L[c] h[c] appnn[e] appnn[c] & apnnox[c] apnnox[e] & & h[e] h[c] h2o[c] h[c] o2[c] o2[e] mhista[c] & h[c] ppi[c] & o2[c] na1[e] & g1p[c] citr_L[e] citr_L[c] & & glytyrlys[e] & glytyrlys[c] serlyshis[e] & serlyshis[c] h[c] & h[c] co2[c] nh4[c] nad[c] & o2[c] pyr[c] CE1352[c] akg[e] akg[c] & & & fprica[c] & h[c] 2c23dh56dhoxin[c] & & h2o[c] o2[c] h2o[c] h[c] nadh[c] h[c] & ile_L[e] CE1352[e] & nadh[c] & & h[e] h[c] & imp[c] & dcamp[c] & udp[c] udpglcur[c] 34dhphe[c] tyr_L[c] nh4[c] amet[c] & apoC_Lys_btn[c] h2o2[c] h2o[c] & & & & amp[c] adp[c] & atp[c] coa[c] o2[c] apoC[c] & apoC_Lys[c] glu_L[c] & gdpmann[c] h2o[c] nadph[c] & & glyvalhis[e] glyvalhis[c] serphelys[e] & serphelys[c] pi[c] o2[c] thbpt4acam[c] ahcys[c] ala_L[c] ser_L[e] cys_L[c] h[e] h[c] gtp[c] gtp[c] gdp[c] h[c] & nadh[c] coa[c] nad[c] & h[c] thbpt[c] thbpt4acam[c] & & & gdp[c] o2[c] h[c] h2o[c] gly[c] gly[e] adp[c] atp[c] h2o[c] dopa[e] h[c] nadph[c] sprm[c] h2o[c] h2o2[c] h2o[c] h[c] h2o[c] CE1918[c] CE6205[c] & ile_L[c] na1[e] adp[c] h[c]na1[c] nad[c] nadp[c] nadp[c] 2hydog[c] & 2hydog[e] hisargcys[e] & hisargcys[c] sertrphis[e] & sertrphis[c] gdp[c] o2[c] thbpt[c] ahcys[c] 2m3hvac[e] atp[c] pi[c] o2[c] h[e] h[c] h2o[c] CE5626[c] h[e] 4abutn[c] n8aspmd[c] h2o[c] & h[c] akg[c] & M00605[c] h[c] h2o[c] gln_L[c] h[c] & h[c] tmlys[e] nadp[c] amet[c] & & prgnlone[c] citr_L[e] & citr_L[c] hisargser[e] & hisargser[c] thrargtyr[e] & thrargtyr[c] asp_L[c] dhbpt[c] gudac[c] h[c] nadph[c] & h2o[c] carveol[c] carveol[e] h[e] h[c] aicar[e] itp[c] & h[c] h[c] & CE5276[c] nrpphrsf[e] h2o[c] h2o[c] glu_L[c] nadh[c] h[c] akg[c] akg[c] aprgstrn[e] & aprgstrn[c] M02760[c] h2o[c] prpp[c] idp[c] ppi[c] h2o[c] & & o2[c] h2o[c] h[c] & dolmanp_U[c] & leu_L[c] tyr_L[c] phe_L[c] thr_L[c] tyr_L[c] met_L[c] asn_L[c] pro_L[c] tyr_L[c] trp_L[c] lys_L[c] phe_L[c] hisasp[e] & hisasp[c] thrasntyr[e] & thrasntyr[c] h[c] pi[c] nadp[c] carn[e] gluala[e] N1aspmd[c] spmd[e] gudac[c] limnen[e] limnen[c] 2hydog[c] 2hydog[e] h[e] h[c] 4hphac[c] 3mlda[c] pi[c] & & aclys[e] h2o[c] akg[c] o2[c] nadph[c] & nadph[c] o2[c] & & ala_L[c] & trypta[c] & id3acald[c] & ind3ac[c] ind3ac[e] & ile_L[c] ile_L[e] hiscyscys[e] & hiscyscys[c] thrglnglu[e] & thrglnglu[c] & ppi[c] CE2172[c] CE2172[e] dhbpt[c] o2[c] coa[c] h[c] perillyl[c] perillyl[e] & & cgly[e] h[c] nadh[c] nad[c] thbpt[c] co2[c] accoa[c] mhista[e] h2o[c] h[e] h[c] gthrd[c] co2[c] h2o[c] Lfmkynr[c] & Lkynr[c] & hLkynr[c] & 3hanthrn[c] hpyr[c] oh1[c] oh1[e] hisglnala[e] & hisglnala[c] thrglntyr[e] & thrglntyr[c] itp[e] h[c] & h[e] o2[c] gthrd[e] ac[c] h[c] h2o[c] o2[c] nh4[c] nad[c] ahcys[c] h[c] 5HPET[e] 5HPET[c] & h2o[c] h2o[c] & h2o[c] o2[c] phe_L[c] & h[c] Ndmelys[c] h2o2[c] h[c] nadh[c] o2[c] ala_L[c] nad[c] nadph[c] h2o[c] orn[e] orn[c] h[e] h[c] nh4[c] & phpyr[c] & 2hyoxplac[c] for[c] nad[c] & o2[c] hisglu[e] & hisglu[c] thrhishis[e] & thrhishis[c] CE1562[c] nadp[c] & 34hpp[c] & 34hpl[c] sprm[e] acorn[c] & h2o[c] h[c] h2o[c] h2o[c] o2[c] nh4[c] h2o[c] na1[e] ile_L[e] cbp[c] o2[c] h[c] nadph[c] nadp[c] ala_L[c] Limonene and pinene h[e] h[c] h2o2[c] nadp[c] thbpt[c] akg[c] nadh[c] h[c] CE2089[c] CE2088[c] nadp[c] hisglugln[e] & hisglugln[c] thrilearg[e] & thrilearg[c] h[c] n8aspmd[e] trp_L[c] leu_L[e] & dhap[e] dhap[c] adp[c] & & & pi[c] h[c] hom_L[c] hom_L[e] h[e] h[c] nadph[c] h[c] nrpphrsf[c] & hmcr[c] & phe_L[e] h[c] atp[c] & h2o[c] h2o[c] nadh[c] h2o2[c] na1[e] nad[c] phe_L[e] & ac[c] & h2o[c] atp[c] adp[c] & gln_L[c] hisglylys[e] hisglylys[c] thrmetarg[e] & thrmetarg[c] pi[c] h[c] nad[c] 3mlda[e] h2o[c] nadp[c] & h[e] h[c] h2o[c] na1[c] h[e] na1[c] ile_L[e] akg[e] & orn[e] & orn[c] hishislys[e] & hishislys[c] thrphearg[e] & thrphearg[c] o2[c] pap[c] bamppald[c] leu_L[c] phe_L[c] trp_L[e] C03681[e] & C03681[c] C14826[e] C14826[c] fe2[e] fe2[c] & camp[c] h[c] h[c] nad[c] ile_L[c] co2[c] phlac[c] 2hyoxplac[e] nadp[c] pi[c] lnlc[e] h2o[c] h[e] h[c] & udp[c] akg[c] h2o[c] hislysala[e] & hislysala[c] thrserarg[e] & thrserarg[c] nad[c] & normete_L[c] & 3m4hpga[c] udpglcur[c] & Lkynr[e] & adp[c] prgstrn[e] nh4[c] h2o2[c] & crtstrn[c] h[e] h[c] & pap[c] h2o2[c] & M00673[c] & nadph[c] h2o[c] h[c] thr_L[c] thr_L[e] hislysglu[e] & hislysglu[c] & o2[c] 21hprgnlone[c] & 21hprgnlone[e] thrthrarg[e] & thrthrarg[c] tymsf[e] pi[c] na1[e] ile_L[c] Tryptophan h[c] cyst_L[e] cyst_L[c] h[e] h[c] & 3hpppnoh[c] & 3hpppnohgluc[c] h2o[c] trp_L[c] 3hanthrn[e] h[c] hislysile[e] & hislysile[c] thrtyrmet[e] & thrtyrmet[c] fe3[e] h[c] nadp[c] h2o[c] h[c] h2o[c] h2o[c] nadp[c] & fe3[c] h2o[c] Beta-Alanine & nad[c] CE6205[e] orn[e] & orn[c] h[e] h[c] h2o[c] nadp[c] h2o[c] nh4[c] pac[e] hmcr[e] trp_L[e] & nadh[c] hislysthr[e] & hislysthr[c] trpalapro[e] & trpalapro[c] o2[c] h[e] na1[c] h[c] o2[c] nad[c] h2o[c] h[c] nadh[c] h[c] nadp[c] nadh[c] adp[c] h[e] h[c] h2o2[c] spmd[c] & & co2[c] h2o[c] acngalacglcgal14acglcgalgluside_hs[e] acngalacglcgal14acglcgalgluside_hs[c] h[c] h[c] adp[c] nadp[c] nh4[c] CE1918[e] hLkynr[e] hislysval[e] & hislysval[c] trpargala[e] & trpargala[c] 4hoxpacd[c] h2o[c] atp[c] h[c] pi[c] asn_L[c] asn_L[e] sercysarg[c] hisargser[c] argarg[c] ileargile[c] thrilearg[c] ileserarg[c] argserser[c] serargtrp[c] argcysser[c] glygly[c] h[e] h[c] 2c23dh56dhoxin[c] & 56dihindlcrbxlt[c] atp[c] & sertrphis[c] alaala[c] ppi[c] & L_dpchrm[c] h[c] nadh[c] pacald[c] & h[c] hismet[e] & hismet[c] trpaspasp[e] & trpaspasp[c] cl[e] cl[c] CE4890[e] & CE4890[c] pac[c] peamn[c] & & pac[c] & phaccoa[c] & pheacgln[c] & & & & h[e] h[c] atp[c] h2o[c] pheacgln[e] nadph[c] & & atp[c] orn[e] & orn[c] & & hismetgln[e] & hismetgln[c] trpglngln[e] & trpglngln[c] & nh4[c] ahcys[c] h2o[c] h2o[c] h2o[c] atp[c] o2[c] h[c] acorn[c] acorn[e] & & h[e] h[c] i[e] & i[c] h2o2[c] h2o2[c] h2o[c] o2[c] h[c] ppi[c] h[c] nadp[c] nadph[c] & C14826[e] & & fad[c] & fmn[c] h[c] paps[c] h[c] nadph[c] h2o2[c] gln_L[c] nadph[c] thr_L[c] hisphearg[e] & hisphearg[c] trpglugly[e] & trpglugly[c] & ribflv[c] & ahcys[c] h2o[c] & & h2o[c] h[c] nadp[c] & & nadp[c] nadph[c] amp[c] M00285[c] h2o[c] h[e] h[c] & o2[c] h[c] Phenylalanine coa[c] coa[c] & prgstrn[c] & 11docrtstrn[c] o2[c] h2o[c] atp[c] h[c] adp[c] pi[c] hisprolys[e] & hisprolys[c] trpgluleu[e] & trpgluleu[c] cys_L[c] cys_L[e] nad[c] h2o[c] h[c] h[c] h2o[c] amet[c] & o2[c] glu_L[c] h[c] nadp[c] 3ohsebac[c] 3ohsebac[e] h[e] h[c] pi[c] pap[c] h2o[c] histrphis[e] & histrphis[c] trpglupro[e] & trpglupro[c] amp[c] h2o[c] Tyrosine & pyr[c] h2o[c] 3hpppnohgluc[e] h[c] h2o[c] h[c] nadph[c] C14826[c] & h2o[c] & CE1261[e] C09642[e] C09642[c] h[c] & gthox[c] nadph[c] lnlc[c] & & CE2049[c] & CE2049[e] orn[e] & orn[c] cys_L[c] ser_L[c] his_L[c] gly[c] ile_L[c] argalaala[c] ile_L[c] ser_L[c] ala_L[c] ser_L[c] ser_L[c] arg_L[c] h[e] h[c] melanin[c] & o2[c] o2[c] h2o[c] ileargile[e] & ileargile[c] trpglutyr[e] & trpglutyr[c] nrpphr[e] pi[c] adp[c] o2[c] sucaceto[c] sucaceto[e] gthrd[c] h2o[c] h[c] nadph[c] h2o[c] h[e] h[c] paps[c] & & triodthysuf[e] galgluside_hs[e] o2[c] & o2[c] ileasnhis[e] & ileasnhis[c] trpglyasp[e] & trpglyasp[c] h[c] cys_L[c] h2o[c] atp[c] nadh[c] h[c] h2o[c] h[c] o2[c] crmp_hs[e] gd1c_hs[e] & atp[c] h2o[c] h[e] h[c] fad[c] & fadh2[c] o2[c] & na1[e] hco3[c] 3hpppn[c] & 3hpppn[e] o2[c] h2o[c] digalside_hs[c] udp[c] h2o[c] crtsl[e] CE2839[c] CE2839[e] tyr_L[c] tyr_L[e] fad[e] adrnl[e] amet[c] h[c] ahcys[c] acgal[e] acgal[c] ileasp[e] & ileasp[c] trpglyleu[e] & trpglyleu[c] pi[c] adrnl[e] & atp[c] h[c] h[c] C08261[c] h[e] h[c] & Linoleate nadph[c] glu5sa[c] glu_L[m] h[e] gthrd[e]hco3[e] hco3[c] coumarin[e] coumarin[c] & hcoumarin[c] hcoumarin[e] npthl[e] npthl[c] & onpthl[c] onpthl[e] udpgal[c] h[c] & h[c] h[c] orn[e] & orn[c] ileglnglu[e] & ileglnglu[c] trpglyphe[e] & trpglyphe[c] nadh[c] fadh2[c] nadp[c] tymsf[c] & tym[c] CE1261[c] & dopaqn[c] & & gthrd[e] pi[c] h[c] h2o[c] h2o[c] h[c] h[e] h[c] h[c] amet[c] h2o[c] gthrd[c] sphgn[c] & h[c] nadph[c] adp[c] co2[c] o2[c] adp[c] 13dampp[c] h2o[c] adp[c] pi[c] h2o[c] & galgluside_hs[c] ga2_hs[c] nadp[c] nadph[c] M01881[c] M01881[e] ileglyarg[e] & ileglyarg[c] trpglyval[e] & trpglyval[c] atp[c] fald[c] h[c] 34dhoxmand[c] & 3mox4hoxm[c] mma[c] nad[c] nadph[c] nadph[c] & adp[c] arg_L[c] h[e] h[c] gthrd[c] & hco3[e] h2o2[c] & h2o[c] nadh[c] h[c] nadp[c] nadp[c] HC02070[c] nadph[c] nadph[c] h2o[c] nadp[c] h[c] fad[c] & nadp[c] nadp[c] trp_L[c] trp_L[e] ileprolys[e] & ileprolys[c] trphismet[e] & trphismet[c] & h[c] nadh[c] atp[c] h[c] fadh2[c] udpgal[c] CE2576[c] CE2577[c] CE6506[c] CE2006[c] h2o[c] na1[c] h[c] nadp[c] udp[c] h[c] h[e] h[c] VitB2 h[e] h[c] leu_L[c] leu_L[e] & ahcys[c] & & h[c] 4hoxpacd[c] & 4hphac[c] triodthysuf[c] & HC02187[c] HC02187[e] galside_hs[c] pi[c] h2o[c] h[c] h2o[c] ileserarg[e] & ileserarg[c] trpilelys[e] & trpilelys[c] h2o[e] nadp[c] leu_L[e] ahcys[c] mepi[c] & 3m4hpga[c] crmp_hs[c] phcrm_hs[c] cortsn[e] cortsn[c] & crtsl[c] & M00603[c] & 17ahprgstrn[c] M01966[c] M01966[e] h[c] o2[c] amet[c] nad[c] h[c] o2[c] h2o[c] h[c] h2o[c] h[c] & M03131[c] orn[e] & orn[c] h[e] h[c] h2o[c] & h2o[c] acald[c] h[c] h[c] h[c] o2[c] h2o[c] leuasnasp[e] & leuasnasp[c] trpiletrp[e] & trpiletrp[c] CE2176[e] & h2o[c] & h[c] paps[c] C01747[c] h2o[c] gd1c_hs[c] o2[c] 11docrtstrn[e] h2o[c] fad[e] & fmn[e] CE5026[c] h[c] h[c] h2o[c] pap[c] h[c] h[c] h2o[c] h[c] h2o[c] h[c] nadph[c] ser_L[c] C04717[e] & C04717[c] & C01601[c] atp[c] h[e] h[c] h[c] o2[c] h2o2[c] 3mox4hoxm[c] h[c] nadph[c] o2[c] aflatoxin[e] aflatoxin[c] eaflatoxin[c] eaflatoxin[e] HC02048[c] udp[c] nadph[c] udp[c] & gal[c] iletrptyr[e] & iletrptyr[c] trpleuval[e] & trpleuval[c] & atp[c] h[c] & dopa[c] & nrpphr[c] adrnl[c] & mepi[c] 4abutn[c] & 4abut[c] 4abut[e] nadp[c] h2o2[c] & udp[c] cmp[c] o2[c] ser_D[e] ser_D[c] hdcea[e] & 34dhphe[e] 34dhphe[c] & mepi[e] & nifedipine[e] nifedipine[c] & hnifedipine[c] hnifedipine[e] h2o[c] acnam[c] met_L[c] met_L[e] h[e] h[c] na1[c] adp[c] o2[c] & & hdca[e] hexc[e] hdcea[e] atp[c] & ascb_L[c] h2o[c] na1[e] udp[c] h[c] h2o[c] M03131[e] & adp[c] atp[c] leualaarg[e] leualaarg[c] trplys[e] & trplys[c] elaid[e] hpdca[e] amp[e] peamn[c] h2o[c] dhdascb[c] & nadph[c] pi[c] & & h2o[c] h2o[c] h[e] h[c] hdca[e] hexc[e] nadph[c] h2o2[c] na1[c] na1[e] pro_L[c] nadp[c] nadph[c] h[c] & sphgn[e] h[c] h2o[c] h[c] elaid[e] hpdca[e] h[c] co2[c] & & nadp[c] & h[c] co2[c] co2[c] 1pyr5c[c] & pro_L[e] nadp[c] & M02035[c] M02035[e] orn[e] & orn[c] lysglnphe[e] & lysglnphe[c] trpmetarg[e] & trpmetarg[c] eicostet[e] lgnc[e] & pi[c] leu_L[c] amet[c] hco3[e] amet[c] nh4[c] & & h[c]nadph[c] & h[c] sph1p[e] pi[c] h[e] h[c] h[c] & o2[c] & nadp[c] i[c] nadp[c] nadph[c] sphings[e] thcrm_hs[c] h[c] eicostet[e] lgnc[e] h2o[c] sucacetat[c] h2o[c] h[c] nadph[c] i[c] atp[c] & & & adp[c] C14825[c] & CE2047[c] hisasp[c] pheasp[c] asphispro[c] aspglupro[c] aspglu[c] arglysasp[c] trpaspasp[c] aspglutrp[c] asplysglu[c] aspprolys[c] proargasp[c] tyrasparg[c] leuasplys[e] & leuasplys[c] trpmetval[e] & trpmetval[c] docosac[e] lneldc[e] nadph[c] h2o[c] nad[c] h[c] udpgal[c] nadp[c] camp[e] nadp[c] atp[c] CE6504[c] h[c] h[e] h[c] h[c] ahcys[c] na1[c] gthrd[e] & nh4[c] & na1[c] na1[e] ile_L[e] ile_L[c] h[c] & coa[c] h[c] h2o[c] h[c] & & adp[c] & cl[e] akg[c] & udpacgal[c] h[e] ser_L[c] ser_L[e] & & leuleutrp[e] & leuleutrp[c] trpphe[e] & trpphe[c] docosac[e] lneldc[e] o2[c] & h2o[c] nadh[c] o2[c] h2o[c] pi[c] & h[c] h2o[c] h2o[c] & o2[c] & & adp[c] nad[c] nad[c] nadh[c] h[c] cl[c] CE2866[c] & triodthy[c] & thyox_L[c] h[c] udpgal[c] coa[c] HC02048[c] pi[c] M02491[c] pi[c] & & & h[e] h[c] doco13ac[e] lnlc[e] h2o[c] h[c] fadh2[c] h2o[c] acgal[c] h2o[c] adp[c] pi[c] & & leupro[e] & leupro[c] trpprogly[e] & trpprogly[c] h[c] h[c] CE5026[e] acald[c] & & h2o[c] o2[c] gthrd[c] o2[c] & CE2872[c] & CE2873[c] CE2874[c] & CE2875[c] h2o[c] fad[c] h[c] h[c] & & doco13ac[e] lnlc[e] o2[c] gthrd[c] h2o2[c] 3mox4hoxm[e] co2[c] gm1b_hs[c] & 17ahprgnlone[c] & M00406[c] & 11docrtsl[c] h2o[c] orn[e] & orn[c] arg_L[c] h[e] h[c] na1[c] na1[e] i[c] omeprazole[c] omeprazole[c] & 5homeprazole[c] 5homeprazole[e] & 11docrtsl[e] leuproarg[e] & leuproarg[c] trpproleu[e] & trpproleu[c] vanilpyr[c] & CE2176[c] glu_L[c] nadp[c] & cmp[c] CE2006[e] dlnlcg[e] lnlnca[e] vanillac[e] vanillac[c] & na1[e] na1[c] & & & dhcrm_hs[c] & & udp[c] h[c] & h[e] h[c] pi[c] nad[c] nadh[c] nad[c] h[c] mma[c] & fald[c] succ[c] & paps[c] paps[c] pap[c] & sphs1p[e] sphs1p[c] & sphings[c] & spc_hs[c] & sphmyln_hs[c] & crm_hs[c] sphgn[c] sph1p[c] cmp[c] Glycosphingolipid pi[c] O-Glycan leusertrp[e] & leusertrp[c] trpproval[e] & trpproval[c] dlnlcg[e] lnlnca[e] hgentis[e] & & 34dhmald[c] pap[c] nadph[c] nadp[c] h2o[c] h[c] & h2o[c] nadph[c] nadh[c] h[c] na1[e] hco3[c] 2obut[c] ala_L[e] h2o[c] nadp[c] M02467[c] M02467[e] gln_L[c] gln_L[e] h[e] h[c] ddca[e] lnlncg[e] co2[c] thbpt4acam[c] & ala_L[c] h[c] udpacgal[c] gbside_hs[c] & galgbside_hs[c] & his_L[c] phe_L[c] his_L[c] pro_L[c] glu_L[c] lys_L[c] trp_L[c] glu_L[c] lys_L[c] pro_L[c] arg_L[c] tyr_L[c] leutrp[e] & leutrp[c] trpsertyr[e] & trpsertyr[c] glu_L[c] h2o[c] nadph[c] h[c] h2o[c] h2o[c] pchol_hs[c] & h[c] h2o[c] core5[e] core7[e] adp[c] ddca[e] lnlncg[e] & & 34dhoxpeg[c] o2[c] sph1p[c] core8[e] atp[c] ump[c] nadh[c] Ser_Gly_Ala_X_Gly[c] h[c] h[e] h[c] h[c] akg[c] dopa[e] & 4hpro_LT[c] & 4hpro_LT[e] atp[c] & o2[c] Rtotalcoa[c] atp[c] h[c] camp[c] nad[c] orn[e] & orn[c] leutrparg[e] & leutrparg[c] trpthrglu[e] & trpthrglu[c] o2[c] o2[c] h2o[c] adp[c] h[c] Rtotal[c] dag_hs[c] nad[c] adp[c] h[c] h[e] dcsptn1[e] M00003[e] h[c] glu_L[c] for[c] h[c] nadh[c] udp[c] & h[e] h[c] h[c] h2o2[c] HC02187[c] coa[c] leutyrtyr[e] & leutyrtyr[c] trpthrile[e] & trpthrile[c] dcsptn1[e] M00003[e] nh4[c] nadh[c] udpgal[c] & o2[c] thbpt[c] akg[c] & cmpacna[c] h[e] h[c] crvnc[e] M00008[e] nadp[c]h2o2[c] & taxol[e] taxol[c] & htaxol[c] htaxol[e] nadp[c] spc_hs[e] nadp[c] gly[c] gly[e] leuval[e] & leuval[c] trpthrtyr[e] & trpthrtyr[c] h2o2[c] nad[c] whddca[c] & ddca[c] h[c] dag_hs[c] acgal[c] crvnc[e] M00008[e] h[c] Arginine_Proline pchol_hs[c] h[c] & h[e] h[c] & h[c] lysargleu[e] & lysargleu[c] & & 34hpp[c] & h2o[c] cl[c] na1[c]na1[e] cl[e] nadph[c] HC02228[c] & hxdcal[c] ethamp[c] & h[e] h[c] trptyrgln[e] trptyrgln[c] clpnd[e] M00010[e] 4fumacac[c] 4mlacac[c] & hgentis[c] & 34dhoxpeg[e] nad[c] sphmyln1825_hs[c] ga1_hs[c] gal[c] orn[e] & orn[c] h[e] h[c] tyr_L[c] nadph[c] h2o[c] h2o[c] nad[c] nadp[c] & hco3[e] hco3[c] asp_L[c] lyscyshis[e] & lyscyshis[c] trptyrtyr[e] & trptyrtyr[c] clpnd[e] M00010[e] nadph[c] cholp[c] Sphingolipid & ribflv[e] na1[c] o2[c] nadp[c] h[c] o2[c] nadp[c] udpg[c] & udp[c] h[e] h[c] CE2510[e] M00017[e] h2o[c] & leuleu[e] & leuleu[c] trpvalasp[e] & trpvalasp[c] h2o[c] 34dhpac[c] & 34dhpe[c] & o2[c] nadph[c] h2o[c] CE2510[e] M00017[e] h[c] nadph[c] his_L[c] his_L[e] h[e] h[c] o2[c] ile_L[e] 3moxtyr[c] & h2o2[c] o2s[c] ethamp[c] tyrala[e] & tyrala[c] na1[e] & atp[c] & h2o[c] & & C02356[c] h[c] o2[c] h2o[c] crm_hs[e] adp[c] leugly[e] & leugly[c] arachd[e] M00019[e] o2[c] akg[c] adp[c] & & udp[c] h2o[c] h[e] h[c] h2o[c] nadph[c] & h[c] & h2o[c] orn[e] & orn[c] glypro[e] & glypro[c] tyralaphe[e] & tyralaphe[c] arachd[e] M00019[e] & ahcys[c] amet[c] nad[c] h2o[c] h[e] h[c] h[c] h[c] tolbutamide[e] tolbutamide[c] & 4mtolbutamide[c] 4mtolbutamide[c] hhxdcal[c] phsph1p[c] h2o[c] h[c] M02197[c] arach[e] M00021[e] & tyr_L[e] ile_L[c] h[c] nadh[c] h[c] icdchol[c] & lysgluglu[e] & lysgluglu[c] tyrargglu[e] & tyrargglu[c] nadp[c] nadp[c] 3dsphgn[c] paps[c] icdchol[e] arach[e] M00021[e] nadp[c] o2[c] nadh[c] h2o[c] h[c] gq1b_hs[e] core5[c] f1a[e] amp[c] ksii_core4[e] ksii_core2[e] atp[c] h[e] h[c] pi[c] & & nadph[c] nadp[c] nadp[c] adp[c] core7[e] core8[c] core4[e] lyslyslys[e] & lyslyslys[c] tyrargser[e] & tyrargser[c] & h[c] o2[c] nadph[c] h[c] glc_D[c] lcts[e] h[c] h[e] h[c] adrn[e] M00115[e] h2o[c] h2o[c] homoval[e] nadh[c] nadph[c] h2o[c] coa[c] cmp[c] core7[c] pi[c] na1[e] na1[c] iodine[c] akg[c] h[c] h[c] h[c] h[c] core8[e] lyspheile[e] & lyspheile[c] tyrasparg[e] & tyrasparg[c] adrn[e] M00115[e] nadh[c] oxa[c] co2[c] core5[e] 34hpp[e] h2o2[c] & h[c] o2[c] h2o[c] glnlyslys[c] lyscyshis[c] lyslyslys[c] asplyshis[c] hishislys[c] leuasplys[c] trplys[c] lystrparg[c] argarglys[c] lysvalphe[c] hislysval[c] glnhislys[c] h[e] h[c] M02560[e] M00117[e] h[c] & hdca[c] & whhdca[c] gluside_hs[e] gluside_hs[c] udp[c] h2o[c] & lystrparg[e] & lystrparg[c] tyrcysgly[e] & tyrcysgly[c] co2[c] Cytochrome udpacgal[c] cmp[c] hom_L[e] hom_L[c] & & M02561[e] & M00117[e] fum[c] HC01522[c] h2o2[c] h[c] so4[c] nadph[c] & & & & h[e] h[c] 3moxtyr[e] h[c] C02356[e] h[e] h[c] gthox[c] & na1[c] na1[e] & & & lystyrile[e] & lystyrile[c] tyrcysthr[e] & tyrcysthr[c] nad[c] & h2o[c] debrisoquine[e] debrisoquine[c] & 4hdebrisoquine[c] 4hdebrisoquine[e] gm1_hs[c] gm2_hs[c] & & vacc[e] M00260[e] h[c] ascb_L[c] atp[c] gd2_hs[c] & & sphmyln_hs[e] h2o[c] citr_L[c] & citr_L[e] & & h[e] h[c] nh4[c] h[c] Sfglutth[c] thrnt[c] & 23doguln[c] gthrd[c] h[c] gd3_hs[c] & gt3_hs[c] h[c] h[c] & asp_L[c] lysvalphe[e] & lysvalphe[c] tyrglu[e] & tyrglu[c] vacc[e] M00260[e] coa[c] akg[e] nadph[c] ppi[c] amet[c] pro_D[e] & pro_D[c] nadp[c] ttdca[c] pi[c] h[e] h[c] ttdcea[e] M00265[e] 1p3h5c[c] nadph[c] h[c] cmp[c] h[c] ump[c] digalsgalside_hs[e] pi[c] adp[c] na1[e] na1[c] lysvaltrp[e] & lysvaltrp[c] tyrleuarg[e] & tyrleuarg[c] 3mox4hpac[c] & homoval[c] & 34dhpha[c] 34dhpha[e] & phsphings[c] & udp[c] udpgal[c] h2o[c] h[e] h[c] ttdcea[e] M00265[e] acac[c] & aacoa[c] coa[c] cmp[c] gd1a_hs[c] & gt1a_hs[c] & gq1b_hs[c] 34dhoxmand[e] h[c] ksii_core4[g] metargleu[e] & metargleu[c] tyrphetyr[e] & tyrphetyr[c] ttdca[e] M00315[e] amp[c] nadh[c] 34dhoxmand[c] dhdascb[c] & h[c] O-glycan metabolism ksii_core2[g] pi[c] gln_L[c] his_L[c] cys_L[c] asp_L[c] his_L[c] leu_L[c] trp_L[c] arg_L[c] phe_L[c] val_L[c] his_L[c] gln_L[c] h[e] h[c] atp[c] hco3[e] hco3[c] h[c] o2[c] h[c] & amp[g] leuktrB4woh[c] & leuktrB4woh[e] hom_L[e] hom_L[c] ttdca[e] M00315[e] accoa[c] aacoa[c] homoval[c] h[c] h2o[c] udpgal[c] cmp[c] camp[g] metasntyr[e] & metasntyr[c] tyrthr[e] & tyrthr[c] i[e] i[c] h[c] ser_L[c] pap[g] h[g] h[c] h2o[c] & adp[c] atp[c] h[e] h[c] tmndnc[e] M00341[e] gthrd[e] gthrd[c] h2o[g] h[g] h[g] h[c] orn[c] & orn[e] metglntyr[e] & metglntyr[c] tyrtrpphe[e] & tyrtrpphe[c] ahcys[c] 4nph[e] 4nph[c] & 24nph[c] 24nph[e] & h2o[c] f1a[g] & & h[e] h[c] tmndnc[e] M00341[e] & VitC & ump[g] 34dhpe[e] o2[c] paps[g] Ser_Gly_Ala_X_Gly[g] metglyarg[e] & metglyarg[c] tyrtyr[e] & tyrtyr[c] acnam[c] M01870[e] N-glycan metabolism udp[g] h[g] udp[g] & ump[g] h[c] tettet6[e] M01197[e] adp[c] nadph[c] pmtcoa[c] h[e] h[c] & 3ityr_L[e] & 3ityr_L[c] & triodthy[c] triodthy[e] paps[c] nadp[c] & & & Lhcystin[c] Lhcystin[e] & tyrvalmet[e] & tyrvalmet[c] tettet6[e] M01197[e] h2o[c] orn[e] orn[c] methislys[e] methislys[c] & h[c] h[c] udp[g] pi[g] 35cgmp[g] & gmp[g] ksii_core4_pre10[g] ksii_core2_pre10[g] h[e] h[c] tetpent6[e] M01207[e] & & & atp[c] adp[c] valarggly[e] & valarggly[c] 2amac[c] paps[c] nadp[c] nadph[c] h[g] ump[g] glc_D[g] metmetile[e] & metmetile[c] tetpent6[e] M01207[e] h[e] na1[e] & acgal[c] udp[c] atp[g] atp[c] amp[c] citr_L[c] & citr_L[e] lys_L[c] h[e] h[c] na1[c] h2o2[c] h2o[c] hco3[e] hco3[c] h[c] udp[c] h[c] n5m2masn[e] udpgal[g] udp[g] udp[g] metphearg[e] & metphearg[c] valhisasn[e] & valhisasn[c] h[c] nadph[c] Ser_Thr[g] h[g] h2o[g] h[g] h2o[c] h[c] tetpent3[e] M01235[e] iodine[c] na1[c] & Nucleotide interconversion h[g] h[e] h[c] acac[e] & h[c] M01870[g] & M01869[g] core5[g] & lnlc[e] & lnlccoa[c] h2o[c] mettrpphe[e] & mettrpphe[c] valleuphe[e] & valleuphe[c] tetpent3[e] M01235[e] pap[c] h2o[c] core6[g] & & h[g] adp[c] na1[c] na1[c] h[c] pap[c] acnam[c] h2o[c] h[g] digalsgalside_hs[c] adp[g] h2o[c] ppi[c] h[e] h[c] tethex3[e] M01238[e] triodthysuf[c] h[g] core7[g] lcts[g] & udpgal[g] oh1[e] oh1[c] pheasnmet[e] & pheasnmet[c] vallystyr[e] & vallystyr[c] h[c] & 4nphsf[c] 4nphsf[e] udp[g] core8[g] udpgal[g] atp[c] pi[c] coa[c] h[e] h[c] tethex3[e] M01238[e] i[c] h2o[c] & & h[g] gm1_hs[c] & gd1b_hs[c] cmp[c] gt1a_hs[e] & udp[g] udp[g] h[g] Transport T4hcinnm[c] & T4hcinnm[e] pheasp[e] & pheasp[c] valphearg[e] & valphearg[c] strdnc[e] M01582[e] pi[c] & udpacgal[c] n5m2masn[c] n5m2masn[g] ksii_core4_pre9[g] ksii_core2_pre9[g] chsterol[g] & h[e] h[c] i[c] h2o[c] hco3[c] nadp[c] & & udp[g] Lkynr[e] Lkynr[c] strdnc[e] M01582[e] h2o2[c] hco3[e] h[c] o2[c] nadp[c] gm3_hs[c] ump[g] udpacgal[g] & pheglnphe[e] & pheglnphe[c] valprotrp[e] & valprotrp[c] h2o[e] h2o[e] & cmp[c] & Galactose metabolism h[e] h[c] 35diotyr[c] & thyox_L[c] thyox_L[e] & & uacgam[g] h[g] h[g] ptdca[e] M02053[e] na1[e] & h[c] udp[g] h[g] & pheleu[e] & pheleu[c] valserarg[e] & valserarg[c] 5cysgly34dhphe[e] CE1261[e] na1[e] cmpacna[c] pap[g] gly[c] gly[e] h[e] h[c] ptdca[e] M02053[e] CE5026[e] & 5cysgly34dhphe[e] & h2o[c] whttdca[c] udp[g] udpacgal[g] udpgal[g] h[g] h[g] h[g] h[g] h[g] h[g] h[g] h[g] na1[e] hco3[e] hco3[c] dmantipyrine[c] dmantipyrine[e] acnam[c] acgal[g] lneldc[e] lneldc[c] gluleu[c] arggluglu[c] glntrpglu[c] glumet[c] glumethis[c] hisglu[c] glnproglu[c] lysgluglu[c] gluthrlys[c] thrglnglu[c] gluglu[c] hislysglu[c] pheleuasp[e] & pheleuasp[c] valtrpphe[e] & valtrpphe[c] ocdcea[e] M02457[e] & antipyrene[e] antipyrene[c] & cmpacna[c] & & h[e] h[c] h2o2[c] & Tn_antigen[g] udp[g] cmp[g] udp[g] udp[g] udp[g] udp[g] udp[g] ser_D[e] & ser_D[c] & & ocdcea[e] M02457[e] cmpacna[c] M01871[g] paps[g] pa_hs[g] sphmyln_hs[g] sphings[g] & & pheleuhis[e] & pheleuhis[c] valtrpval[e] & valtrpval[c] glu_L[e] gly[e] na1[c] & atp[c] ump[c] sgalside_hs[g] digalsgalside_hs[g] na1[c] na1[e] & & ocdca[e] M02613[e] 2amac[c] whttdca[e] h[g] h[c] h[e] & & & h[e] h[c] gthrd[e] & h[e] & & phelysala[e] & phelysala[c] valval[e] & valval[c] ocdca[e] M02613[e] 35diotyr[e] gthrd[c] C01041[c] gq1balpha_hs[c] udpgal[g] & core3[g] & core4[g] & nrvnc[e] M02745[e] na1[e] & & ksii_core4_pre1[g] & ksii_core4_pre2[g] & ksii_core4_pre3[g] & ksii_core4_pre4[g] & ksii_core4_pre5[g] & ksii_core4_pre6[g] & ksii_core4_pre7[g] & ksii_core4_pre8[g] h[e] lpam[e] & lpam[c] ahcys[e] amet[e] gln_L[c] h[e] h[c] M03153[e] M03045[e] ebastineoh[c] cmpacna[c] & h[g] h[c] nrvnc[e] M02745[e] nadph[c] dag_hs[g] h2o[g] Rtotal[g] M03051[e] M03153[e] M03045[e] h[g] udp[g] h[g] pap[g] & M03051[e] dhdascb[e] nadh[c] & uacgam[g] h[g] udp[g] h[e] h[c] mhista[e] & hista[e] nad[c] & udp[g] i[c] i[e] adp[c] h[c] h[c] chol[g] cholp[g] h2o[g] k[g] & k[c] k[e] lue_L[c] arg_L[c] trp_L[c] gln_L[c] met_L[c] his_L[c] pro_L[c] lys_L[c] thr_L[c] gln_L[c] lys_L[c] his_L[c] fald[e] h[g] & h2o[c] ascb_L[e] cmp[c] h2o[c] & & meoh[c] & udp[g] T_antigen[g] & h[g] lthstrl[c] & lthstrl[e] h[e] meoh[e] & fald[c] h[c] cmpacna[g] cl[c] cl[e] pi[c] pi[e] ppi[e] & & atp[c] atp[e] ebastine[c] h[c] cmp[c] cmpacna[g] uacgam[g] paps[g] pap[g] uacgam[g] & na1[e] h[c] M01872[e] M01872[g] uacgam[g] udpgal[g] uacgam[g] udpgal[g] na1[c] h2o2[c] & & cmp[g] & h[g] pi[c] h2o[c] & & & pan4p[e] gt1b_hs[c] & gq1balpha_hs[c] gq1balpha_hs[e] paps[g] h[e] Eicosanoid atp[c] & h[g] cmpacna[c] cmp[g] h[g] cmpacna[g] udpgal[g] glu_L[c] chsterol[e] cmp[c] h2o[g] udp[g] hco3[c] hco3[e] coa[c] ppi[c] metabolism pi[c] sTn_antigen[e] sTn_antigen[c] sTn_antigen[g] sT_antigen[g] na1[e] h[e] h[c] atp[c] udp[g] h[g] crm_hs[g] & galside_hs[g] & digalside_hs[g] na1[c] h2o[c] chsterol[c] sTn_antigen[e] & na1[g] 4abut[e] & 4abut[c] cortsn[c] adp[c] h2o[c] acrn[e] & core2[g] & & & & h[g] udp[g] & ksii_core2_pre1[g] ksii_core2_pre2[g] & ksii_core2_pre3[g] & ksii_core2_pre4[g] & ksii_core2_pre5[g] & ksii_core2_pre6[g] ksii_core2_pre7[g] ksii_core2_pre8[g] h[g] cl[e] cl[c] ttdca[e] Arachidonic acid metabolism 7dhchsterol[c] gncore1[e] gncore1[c] gncore1[g] udp[g] cmp[g] udp[g] udp[g] udp[g] udp[g] udp[g] udp[g] pchol_hs[g] h[g] h[c] dca24g[e] h[g] cmp[g] udpgal[g] fad[c] h[g] h[g] h[g] h[g] h[g] h[g] h[g] h[g] h[g] HC02217[e] dsT_antigen[e] dsT_antigen[c] h[c] xoldiolone[c] pi[c] na1[e] dsT_antigen[g] mqn10[c] mqn10[e] adp[c] fadh2[c] ebastine[e] ebastineoh[e] coke[e] dsT_antigen[e] udp[g] Glycerophospholipid metabolism Glycosphingolipid metabolism leutrp[c] leuleutrp[c] trpgluleu[c] leutrparg[c] argleuphe[c] pheleu[c] lysargleu[c] gluargleu[c] leupro[c] proleuarg[c] leuproarg[c] trpproleu[c] trpleuval[c] atp[c] hco3[c] omhdocosac[c] docosdiac[c] bz[c] gthrd[c] adp[c] akg[c] akg[e] & pi[c] xol7aone[c] gncore2[c] gncore2[g] & & & & h2o[c] lthstrl[c] gncore2[e] Keratan sulfate synthesis mqn11[c] mqn11[e] & & & h[g] estrones[e] & estrones[c] & & & h[c] dsmsterol[c] h[c] h[e] na1[e] na1[c] & & & & xol25oh[c] xol25oh[e] docosac[c] Sphingolipid metabolism h[c] wharachd[c] wharachd[e] chsterols[c] udpacgal[g] & udp[g] mqn7[c] mqn7[e] atp[c] & tym[c] & tym[e] HC02220[e] & HC02220[c] C05769[e] C05769[c] & xoltri25[c] xoltri25[e] & gdp[g] udp[g] hco3[c] mal_L[e] mal_L[c] acgalfucgalacglcgal14acglcgalgluside_hs[g] & galacgalfucgalacglcgal14acglcgalgluside_hs[g] & fucgalacgalfucgalacglcgal14acglcgalgluside_hs[g] & acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs[g] acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs[c] galfucgalacglcgal14acglcgalgluside_hs[e] & gthrd[e] hco3[e] h2o[c] h[g] h[g] trp_L[c] trp_L[c] glu_L[c] trp_L[c] arg_L[c] phe_L[c] lys_L[c] arg_L[c] pro_L[c] arg_L[c] pro_L[c] trp_L[c] val_L[c] gthrd[c] hco3[e] xoltri24[c] xoltri24[e] na1[c] h[c] h[e] hco3[c] hco3[e] tmndnc[c] h[g] h[g] mqn8[c] mqn8[e] cl[e] cl[c] h[c] frdp[c] cspg_b[e] 18harachd[e] gthrd[e] glcur[c] ebastineoh[c] egme[c] atp[c] cspg_b[g] & cs_b_pre5[g] & cs_b_pre4[g] h[g] 12harachd[e] xol24oh[c] acald[c] gullac[c] guln[c] glac[c] dhcrm_hs[c] ebastine[c] whhdca[c] phsphings[c] Rtotal[c] galside_hs[c] h[c] ppi[c] amp[c] udp[g] h[g] melatn[c] melatn[e] HC02217[e] accoa[c] ahcys[c] cmp[c] cmpacna[c] coa[c] trypta[c] & trypta[e] dhcholestanate[c] dca[c] arachd[c] lnlncg[c] dlnlcg[c] pa_hs[c] chol[c] pchol_hs[c] amet[c] pe_hs[c] lnlccrn[c] HC02057[c] hdca[c] lnlc[c] ethamp[c] phcrm_hs[c] cdpchol[c] sphmyln_hs[c] & gdpfuc[g] & prostgh2[c] HC02217[c] hexdiac[c] CE7081[c] hdcea[c] h[g] udpacgal[g] udpgal[g] gdp[g] gdp[c] mqn9[c] mqn9[e] pi[c] cpppg1[c] prostgi2[c] HC02191[c] dca24g[c] dca3g[c] ca24g[c] acrn[c] h2o[e] fuc_L[e] udp[g] udp[g] HC02180[c] hdca24g[c] M02155[c] hdca6g[c] cdca3g[c] C02528[c] dcholcoa[c] cdca24g[c] lca24g[c] lca3g[c] CE1589[c] cholcoa[c] cholate[c] lanost[c] for[c] strdnc[c] coke[c] udpgal[c] CE6234[c] & CE6232[c] ppi[c] & pap[g] udpacgal[g] gdp[g] h[c] h[e] pi[c] h2o[c] xoltri27[c] hexdicoa[c] crn[c] crn[c] crn[c] crn[c] crn[c] udpg[c] chtn[e] h[g] h[g] udp[g] adp[c] prostge2[c] lnlnca[c] omhdecacid[c] atp[c] adp[c] xolest2_hs[c] udp[g] udp[g] h[g] h[g] h[g] mercplaccys[c] mercplaccys[e] h[e] h[c] atp[c] h[c] pi[c] CE0955[c] M02637[c] lnlccoa[c] crn[c] sql[c] crn[c] crn[c] & coa[c] ksi[e] ksi_deg1[e] & adp[c] atp[c] h[c] s9396 h2o[c] & fucgalacglcgal14acglcgalgluside_hs[g] & fucfucgalacglcgal14acglcgalgluside_hs[g] & fucfucfucgalacglcgal14acglcgalgluside_hs[g] fucfucfucgalacglcgal14acglcgalgluside_hs[c] fucfucfucgalacglcgal14acglcgalgluside_hs[e] na1[e] na1[c] & h[c] txa2[c] & hco3[c] leu_L[c] h2o[c] co2[c] h2o[c] o2[c] hca24g[c] hyochol[c] hca6g[c] thcholstoic[c] crn[c] & & cspg_a[e] cspg_a[g] & cs_a_b_pre3[g] & cs_a_b_pre2[g] & cs_a_b_e_pre1[g] & cs_pre[g] & cs_hs_linkage[g] & l2xser[g] & lxser[g] & xser[g] hco3[e] & & & h[c] & & cmp[r] & Rtotal[c] Rtotal[e] mev_R[c] mev_R[e] thymd[e] & thymd[c] cholcoar[c] crn[c] & 4mzym_int1[r] & ctp[c] Rtotalcoa[c] h[g] udp[g] adp[c] pi[c] h2o[c] pi[c] nadp[c] nadph[c] galgluside_hs[r] cdpchol[r] h[r] h[g] h[g] h2o[c] atp[c] o2[c] h2o2[c] h2o[c] nh4[c] h2o[c] C05767[e] & pi[r] h[c] & h2o[c] adp[c] & nadp[r] whhdca[r] crn[r] crn[r] phsphings[r] h2o[r] udpgal[r] udpgal[c] paps[g] hs_pre5[g] h[g] pep[e] pep[c] k[c] k[e] nh4[c] nh4[e] nh4[c] bilglcur[e] s9392 frdp[r] crn[r] R group paps[g] & & adp[r] & h2o[r] & acnamp[c] & acnam[c] na1[e] na1[c] h[e] h[c] pydxn[c] & pdx5p[c] & pydx5p[c] & pyam5p[c] & pydam[c] & pydx[c] crn[r] crn[r] crn[r] udpgal[r] h[g] udp[g] udpglcur[g] ins[e] & ins[c] & & h2o[c] h[r] pi[r] adp[r] arachd[r] CE0955[r] pi[r] nadph[r] tmndnc[r] crn[r] nadp[r] h2o[r] udp[r] & ump[r] ump[c] h2o[c] coa[c] h[g] & udp[g] Rtotal[r] udp[g] udp[g] & & & h2o2[c] h2o2[c] C05770[e] C05770[c] h2o[r] o2[r] crn[r] crn[r] h2o[c] pi[c] h[e] srtn[e] srtn[c] nh4[c] nh4[e] h[c] adp[c] o2[c] o2[c] 15HPET[r] h[r] chsterols[r] ppi[r] h[r] h[r] & gluside_hs[r] Rtotal2coa[c] & Rtotal2[c] & h[c] na1[e] na1[c] h[c] h2o2[c] atp[c] & & cspg_c[e] h[g] & & galfucgalacglcgal14acglcgalgluside_hs[g] galfucgalacglcgal14acglcgalgluside_hs[c] & & hco3[c] nadp[r] nadph[r] & o2[r] & h[r] h[r] for[r] & o2[r] h2o[r] h[r] h[c] cspg_c[g] & cs_c_pre3[g] & cs_c_pre2[g] & cs_c_d_e_pre1[g] hco3[e] hco3[c] h[c] h2o[r] atp[r] & h2o[r] h[r] h[r] h[r] pi[c] h[g] udp[g] & & & ppi[r] udp[r] Nucleotide interconversion h[g] pap[g] h[e] h[c] cl[c] cl[e] C05767[c] 18harachd[c] & 18harachd[r] & o2[r] h2o[r] o2[r] h2o[r] h[r] o2[r] & phcrm_hs[r] udp[r] h2o[c] & h[g] udp[g] uacgam[g] h[g] & selmeth[e] selmeth[c] wharachd[r] atp[r] adp[r] & o2[r] ump[r] pap[g] uacgam[g] h[g] h[g] udp[g] & crn[r] hs_pre4[g] na1[c] na1[e] leuleutrp[c] trpgluleu[c] leutrparg[c] argleuphe[c] pheleu[c] gluargleu[c] lysargleu[c] leutrp[c] leupro[c] proleuarg[c] leuproarg[c] trpproleu[c] trpleuval[c] o2[c] hco3[c] hco3[e] HC01609[c] h[r] & HC02217[r] prostgi2[r] HC02180[r] hca24g[r] & hyochol[r] & hca6g[r] h2o[r] nadp[r] nadph[r] nadp[r] nadph[r] nadp[r] nadph[r] nadp[r] nadph[r] udpg[r] & & sphmyln_hs[r] uacgam[r] & h2o[c] coa[c] hs_pre1[g] Vit B6 adp[r] pi[r] h[r]atp[r] h2o[r] pi[r] acgal[c] itp[c] adp[c] h[c] h[e] & & h2o[c] h2o2[c] h[c] h2o[r] h2o[r] o2[r] nadp[r] atp[c] cspg_d[e] & & atp[c] h[c] h[c] nadp[r] nadph[r] o2[r] h[r] HC01118[r] & sql[r] & Ssq23epx[r] lanost[r] & 44mctr[r] & 44mzym[r] acald[r] dhcrm_hs[r] nadph[r] sph1p[r] & sphgn[r] sphs1p[r] & sphings[r] & crm_hs[r] ump[c] acmanap[c] & Rtotal3[c] cspg_d[g] & cs_d_pre5[g] & cs_d_pre4[g] & cs_d_pre3[g] & & cs_c_d_e_pre1[g] h[g] udp[g] hs_pre6[g] h2o[c] pi[e] pi[c] & & & & udp[r] h2o[r] & pep[c] Rtotal3coa[c] cs_d_pre2[g] & & & h2o[r] & chtn[c] sprm[e] & sprm[c] & & & & h2o[c] & atp[r] amp[r] h[r] nadph[r] xolest2_hs[r] & galside_hs[r] h[r] & h[g] udp[g] gdp[g] gdp[g] gdp[g] & & pydx[c] 4pyrdx[c] adp[c] & 12harachd[r] & & pi[r] pi[r] h[c] h[c] h[c] & isochol[c] & isochol[e] h[c] & 12harachd[c] h[r] h2o[r] txa2[r] prostgd2[c] crn[c] lnlccrn[r] h2o[r] h2o[r] h2o[r] h2o[r] udp[r] adp[c] h[c] & h[g] h[g] & fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs[e] na1[e] & na1[c] udpglcur[r] ppi[r] & cholcoa[r] o2[r] udp[r] h[g] h[g] h[g] udp[g] galacglc13galacglcgal14acglcgalgluside_hs[g] & fucgalacglc13galacglcgal14acglcgalgluside_hs[g] & fucfucgalacglc13galacglcgal14acglcgalgluside_hs[g] & fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs[g] fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs[c] nh4[c] nh4[e] co2[c] & prostge2[r] coa[r] lca24g[r] lca3g[r] ca24g[r] nadph[r] nadp[r] CE7091[r] acmana[r] acmana[e] pyr[c] h[g] atp[c] o2[c] pi[c] & o2[r] & atp[r] h[r] ppi[r] & & udpgal[r] h[r] & h2o[c] paps[g] h[c] pi[e] pi[c] h2o[c] h[r] h[r] & adp[c] idp[c] & udp[g] h[g] h[g] h[g] pi[c] ca2[c] ca2[e] h2o[c] leuktrD4[c] leuktrD4[r] h2o[r] h2o[r] & h[e] h[c] & o2[c] nadph[r] dhcholestanate[r] & dhcholestancoa[r] h[r] h[r] pi[r] udpg[r] udpg[c] atp[c] pmtcoa[c] hs_pre2[g] & udp[g] h[g] & h[r] h2o[r] ppi[r] udp[r] co2[r] o2[r] co2[r] h[r] h2o[r] h[r] h[r] co2[r] hs_pre3[g] trp_L[c] glu_L[c] trp_L[c] arg_L[c] phe_L[c] arg_L[c] lys_L[c] trp_L[c] pro_L[c] arg_L[c] pro_L[c] trp_L[c] val_L[c] crn[r] coa[r] crn[r] coa[r] 4mzym_int2[r] & HC02110[r] & Glycosphingolipid metabolism h[g] & & & atp[c] & glu_L[c] glu_L[r] 12HPET[r] & arachd[r] & prostgh2[r] prostgd2[r] & nadp[r] nadph[r] ump[r] & ump[c] h[c] acgal1p[c] cs_e_pre5a[g] & gdpfuc[g] na1[e] na1[c] & & atp[r] amp[r] udp[r] hdca[r] acgam[c] acmana[c] & pro_D[e] pro_D[c] ppp9[c] pppg9[c] & cpppg3[c] & uppg3[c] h2o[r] o2[r] dca24g[r] dca3g[r] CE1589[r] nadp[r] h[r] nadph[r] h2o[r] h[r] co2[r] nadph[r] nadp[r] nadph[r] nadp[r] nadp[r] h[r] Chondroitin synthesis h[g] h[g] udp[g] & na1[c] na1[e] na1[c] na1[e] & hmbil[c] nadph[r] nadp[r] ppi[r] amp[r] ethamp[r] udpxyl[r] & udpxyl[c] h[g] h[g] udpglcur[r] & ha[e] udp[g] udp[g] ca2[c] ca2[e] h2o2[c] h2o[c] leuktrA4[c] leuktrA4[r] & leuktrC4[r] & o2[r] h2o[r] nadp[r] nadph[r] coa[r] & accoa[r] & acrn[r] lnlccoa[r] & lnlccrn[r] & zymstnl[r] & zymst[r] & zym_int2[r] & 4mzym_int2[r] & 4mzym_int1[r] udp[c] h[c] utp[c] pap[g] h[e] h[c] o2[c] o2[c] co2[c] h[c] h2o[r] crn[r]M02637[r] & & atp[c] & h[c] h[g] hs_pre9[g] & hs_pre8[g] & hs_pre7[g] h2o[c] nh4[c] h[r] atp[r] & fad[r] fadh2[r] udp[c] h[g] cs_e_pre4[g] cs_e_pre3[g] cs_e_pre2[g] galacglcgalacglcgal14acglcgalgluside_hs[g] & fucfucgalacglcgalacglcgal14acglcgalgluside_hs[g] & galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs[g] galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs[c]galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs[e] k[c] k[e] h[c] h2o[r] xoltri27[r] & thcholstoic[r] & cholcoar[r] cspg_e[e] cspg_e[g] & & udp[g] acglc13galacglcgal14acglcgalgluside_hs[g] gthrd[c] gthrd[r] hdca6g[r] udpglcur[r] em2emgacpail_hs[r] Chondroitin synthesis Ser_Gly_Ala_X_Gly[r] h2o[c] & ppi[c] paps[g] h2o[g] udp[g] Nacasp[c] & Nacasp[e] & cdca3g[r] & & chtn[e] & acgam[e] h[g] h[g] h[e] h[c] phpyr[e] & phpyr[c] & CE0347[r] CE4876[r] xol27oh[r] & coa[r] coa[r] hexdiac[r] & hexdicoa[r] & & & h[r] & h[c] adp[g] h[g] fe2[c] h[c] h2o[c] o2[r] o2[r] h[r] udp[r] udp[r] ppi[r] udpglcur[r] h[r] h[c] utp[c] & atp[g] udpglcur[g] h[g] h[c] h[e] h[c] h2o[c] hco3[e] & ppi[c] udpacgal[c] udp[c] uacgam[c] gam[c] udp[g] & udp[g] h[g] udp[g] gdp[g] h[c] h[e] leu_L[c] & gthox[c] gthox[r] & nadp[r] nadph[r] nadh[r] nad[r] nadh[r] nad[r] gam[e] h2o[e] & cs_e_pre5b[g] & zn2[e] & zn2[c] & & h[r] h[r] nadp[r] h2o[r] h[r] o2[r] nadph[r] HC02191[r] amp[r] cholate[r] h[r] atp[r] adp[r] em3gacpail_hs[r] & HC02057[r] udp[r] adp[c] & gdp[c] h[e] h[c] na1[c] & na1[e] o2[r] h[r] atp[r] amp[r] co2[r] o2[r] co2[r] & 5aop[e] & h2o[r] h2o[r] o2[r] nadh[r] nad[r] coa[r] ppi[r] h[r] h[r] chol[r] udpglcur[c] datp[c] atp[c] ac[g] phlac[c] & phlac[e] h2o[c] 5aop[c] ppbng[c] & & h2o[r] acgam6p[c] acgam1p[c] & uacgam[c] & ha_pre1[e] pail_hs[g] h[g]pail5p_hs[g] h[g] gdp[g] & udp[r] atp[r] fad[r] fadh2[r] pi[r] ahcys[r] xser[r] fuc13galacglcgal14acglcgalgluside_hs[e] nac[e] nac[c] cl[c] cl[e] dhdascb[e] C04805[c] C04805[r] & leuktrB4[r] nadph[r] & & & nadp[r] h2o[r] amet[r] gpi_hs[r] itp[c] & HC00822[e] h[e] h[c] & bilglcur[c] nadph[r] xol7aone[r] 20ahchsterol[r] lnlncacoa[r] omhdecacid[r] & dca[r] adp[r] & pap[g] hs_pre10[g] & Heme nadp[r] nadph[r] & & udpglcur[c] h[c] & acglcgalacglcgal14acglcgalgluside_hs[g] fuc13galacglcgal14acglcgalgluside_hs[g] fuc13galacglcgal14acglcgalgluside_hs[c] o2[r] coa[r] h2o[r] & CE7081[r] & Aminosugar & k[c] k[e] h[c] o2[r] & ddsmsterol[r] & & & & & pi[g] h2o[g] h[e] h[c] leuktrB4[c] CE3554[r] & CE2056[r] M02155[r] C02528[r] & dcholcoa[r] & & nadph[r] lthstrl[r] chlstol[r] dsmsterol[r] & uri[e] & uri[c] na1[e] na1[c] h[e] h[c] ascb_L[e] & fe2[e] C05957[r] ppi[r] h[r] h[r] nadp[r] nadph[r] & pa_hs[r] & pchol_hs[r] & pe_hs[r] Inositol phosphate metabolism h[g] & atp[r] gdpfuc[c] na1[c] na1[e] h[r] h[r] h[r] h[r] h[r] h[r] udpglcur[r] amp[r] udpglcur[r] nadph[r] nadp[r] nadph[r] nadph[r] dolichol_L[r] dolichol_L[c] & & pi[r] h2o[r] h2o[r] h2o[r] o2[r] h2o[r] o2[r] docosdiac[r] o2[r] nadp[r] nadph[r] atp[r] h[r] bz[r] hspg[e] hspg[g] & hs_pre15[g] & hs_pre14[g] & hs_pre13[g] & hs_pre12[g] & hs_pre11[g] udp[g] h[g] fe3[e] amp[r] omhdocosac[r] pi[r] gdpfuc[g] mma[e] mma[c] & h[e] pheme[c] bilirub[e] ppbng[e] & h2o[r] & & & coa[r] ppi[r] h2o[r] o2[r] h2o[r] o2[r] h[r] o2[r] h2o[r] h[r] nadp[r] fadh2[r] o2[r] h2o[r] h[r] h2o[r] emem2gacpail_hs[r] & adp[r] atp[r] nadp[r] nadp[r] nadph[r] nadp[r] nadph[r] h[r] & h[r] adp[c] h[g] h[g] galacglcgal14acglcgalgluside_hs[c] h[e] h[c] na1[e] na1[c] odecrn[c] odecrn[e] h2o[r] nadp[r] nadp[r] h[r] dadp[c] h[c] h[g] h[g] prohistyr[c] tyrtyr[c] trptyrtyr[c] tyrleuarg[c] leutyrtyr[c] tyrargglu[c] phetyr[c] tyrphetyr[c] tyrglu[c] trpglutyr[c] tyrtrpphe[c] phetyrlys[c] udp[r] udp[r] nadp[r] nadph[r] h[r] h[r] & h2o[r] h[g] uacgam[g] cmpacna[g] cmp[g] leuktrB4woh[c] & leuktrB4woh[r] & coa[r] h2o[r] & & coa[c] h[c] h[c] & i[e] & i[c] & & nadph[c] na1[e] hco3[c] leuktrB4wcooh[r] & CE2053[r] xoltri24[r] & xol24oh[r] & chsterol[r] gullac[r] & guln[r] & glcur[r] & glac[r] ebastine[r] & ebastineoh[r] coke[r] & egme[r] N-glycan metabolism h[c] accoa[c] tyrcysgly[e] & tyrcysgly[c] & & & pheme[e] h[c] hco3[c] hco3[c] bildglcur[e] dchac[r] h2o[r] h2o[r] nadp[r] h2o[r] cmpacna[c] & & hco3[c] gthrd[c] h[r] h2o[r] hdca24g[r] cdca24g[r] h[r] nadp[r] nadph[r] h[r] nadp[r] nadph[r] nadph[r] nadp[r] ROS detoxification & paps[g] galacglcgal14acglcgalgluside_hs[g] & acngalacglcgal14acglcgalgluside_hs[g] & & & hco3[c] atp[r] & gam6p[c] idp[c] acngalacglcgal14acglcgalgluside_hs[c] & & o2[c] nadph[r] nadp[r] h[r] h[r] nadph[r] h[r] h[r] h[r] h2o[r] h2o[r] h[r] & dolp_L[r] dolp_L[c] & arg_L[c] gchola[e] tchola[e] dchac[e] gthrd[c] HC02201[c] nadh[r] nad[r] h2o[r] o2[r] h2o[r] o2[r] o2[r] 7dhchsterol[r] nadp[r] fad[r] h2o[r] h[r] h2o2[r] o2[r] & psyltdechol[e] & HC02200[c] HC02199[c] o2[r] & & udp[g] h[g] h2o[c] & & & hco3[c] h2o[r] o2[r] glc_D[r] & & & bilglcur[e] & bilglcur[r] nadp[r] nadph[r] nadp[r] nadph[r] & chsterol[r] udpg[r] gdp[g] h[g] gdpfuc[g] h[g] & gdpfuc[g] bglc[e] & glgchlo[e] gumtchol[e] & gum[e] & h2o[c] ac[c] glu_L[c] h2o[c] ump[c] gumdchac[e] HC02199[e] gthrd[e] HC02201[e] & o2[r] nadph[r] nadph[r] so4[r] Cytochrome metabolism Inositol phosphate metabolism hco3[e] adp[r] atp[r] udp[r] xoltri25[r] xol25oh[r] & h[r] & acgam[r] & co[e] co[c] HC02200[e] pi[c] pi[r] & & Alkaloid synthesis & Nucleotide sugar metabolism h[c] cmp[c] pro_L[c] his_L[c] trp_L[c] arg_L[c] leu_L[c] glu_L[c] phe_L[c] phe_L[c] glu_L[c] trp_L[c] phe_L[c] lys_L[c] hco3[e] h2o[r] Vitamin C metabolism & & h[g] gdp[g] & h[r] nad[r] h[r] nadp[r] h[r] udp[r] gdp[g] gchola[e] fe2[c] hco3[e] hco3[e] ump[g] udpgal[g] & hco3[e] na1[c] & na1[r] & nadh[r] N-glycan synthesis h2o[r] & fucfuc132galacglcgal14acglcgalgluside_hs[e] & nadp[c] h[c] na1[c] hco3[e] na1[c] & h2o[r] udpxyl[c] & udpxyl[g] & acglcgal14acglcgalgluside_hs[g] fuc132galacglcgal14acglcgalgluside_hs[g] & fucfuc132galacglcgal14acglcgalgluside_hs[g] fucfuc132galacglcgal14acglcgalgluside_hs[c] gthrd[e] na1[r] & & h[r] h2o[r] dolglcp_L[c] tchola[e] dolglcp_L[r] h[g] tdechola[e] gchola[e] biliverd[e] & biliverd[c] bilirub[c] & udpglcur[r] nh4[c] ump[c] h[g] & bilirub[r] h[r] h[r] udp[g] h[g] dietary fiber binding cortsn[r] pi[r] h2o[r] gln_L[c] co2[g] & crtsl[r] nadph[r] nadph[r] nadp[r] co2[c] gumgchol[e] psyl[e] & psylchol[e] na1[c] udp[c] adp[r] atp[r] nadp[r] bglc[e] & gltcho[e] na1[e] & udp[r] f6p[c] nadph[c] & tyr_L[c] nadp[c] udpglcur[c] bilglcur[c] bilglcur[e] & & xol7aone[r] xol7a[r] ocdcea[r] tchola[e] bildglcur[c] bildglcur[r] & cmpacna[g] gdp[g] & & gdpfuc[g] h2o[c] & adp[r] pi[r] h[r] h2o[r] atp[r] nadp[r] nadph[r] nadph[r] nadh[r] nad[r] crn[c] cmp[g] fucgal14acglcgalgluside_hs[g] h[e] & fucgal14acglcgalgluside_hs[c] fucgal14acglcgalgluside_hs[e] dchac[e] nad[c] h[r] crn[r] & nad[c] nadh[c] h[g] tchola[e] h[e] gthrd[e] gthrd[c] hco3[e] h[r] gtp[c] & h[g] bglc[e] hco3[e] hco3[c] h2o[c] bildglcur[e] & h[c] ppi[c] h[c] h[c] nadh[c] h[c] o2[r] o2[r] fucacngalacglcgalgluside_hs[e] fucacngalacglcgalgluside_hs[c] fucacngalacglcgalgluside_hs[g] & acngalacglcgalgluside_hs[g] & galacglcgalgluside_hs[g] adp[c] atp[c] & & ocdcea[r] ocdcea[c] & gdp[g] uacgam[g] tdechola[e] & gltdechol[e] pectintchol[e] pectindchac[e] atp[c] crtsl[c] h2o[r] h[r] h[r] fuc1p_L[c] & gdpfuc[c] & gdpddman[c] gdpmann[c] & kdnp[c] & pect[e] & psyltchol[e] pi[c] h2o[c] & man1p[c] man6p[c] & h[c] gdpfuc[c] h[r] pi[r] h2o[r] h2o[r] h[g] h[g] udp[g] gdp[c] & adp[c] pep[c] pi[c] nadp[c] h[c] nadph[c] 11docrtsl[c] 11docrtsl[r] & ppi[c] h[c] amp[c] h[c] dadp[c] idp[c] h[g] gchola[e] adp[r] atp[r] nadp[r] nad[r] gtp[c] h2o[c] pi[c] adp[c] adp[c] h[c] acald[r] h[c] h[c] nadp[c] nadph[c] h[c] gdp[c] lyspheile[c] phethrlys[c] phephethr[c] pheproarg[c] argphearg[c] valtrpphe[c] trpphe[c] phetrpleu[c] pheleuasp[c] phephe[c] pheleuhis[c] hisphearg[c] & & h2o[r] h[r]o2[r] nadp[r] nadph[r] o2[r] h[r] h2o[r] h2o[c] udpgal[g] fucacngal14acglcgalgluside_hs[g] fucacngal14acglcgalgluside_hs[c] & acngal14acglcgalgluside_hs[c] h2o[c] atp[c] h[c] pi[c] h[e] CE2209[e] & CE2209[c] & hco3[c] h2o[c] & & dolichol_U[r] dolichol_U[c] & h[c] h[c] & & h[c] h2o[c] & nadp[r] nadph[r] h2o[r] h[r] o2[r] nadph[r] nadp[r] & xoldiolone[r] h[c] Blood group synthesis & & so4[c] 5adtststerones[c] h2o[c] & & & & h[g] gdp[g] & & & adp[c] & & ca2[c] & ca2[e] & & 11docrtstrn[c] 11docrtstrn[r] & prgstrn[r] & 17ahprgstrn[r] & & 5adtststerone[e] 5adtststerone[c] Phosphatidylinositol phosphate metabolism pi[c] udp[g] trp_L[c] h[c] ocdca[r] lnlnca[r] ttdca[r] M00003[r] CE2510[r] ocdcea[r] M00019[r] tmndnc[r] M02053[r] M03051[r] M01238[r] vacc[r] adrn[r] docosac[r] M00021[r] M01235[r] M00008[r] M01582[r] ddca[r] arachd[r] tethex3[r] lneldc[r] crvnc[r] M00017[r] dcsptn1[r] ptdca[r] ttdcea[r] clpnd[r] arach[r] M00341[r] lgnc[r] nrvnc[r] M03153[r] hexc[r] lnlncg[r] eicostet[r] tetpent6[r] M03045[r] M01207[r] doco13ac[r] strdnc[r] M02457[r] tettet6[r] M01197[r] M02613[r] elaid[r] hpdca[r] M00010[r] M02745[r] M00117[r] tetpent3[r] hdca[r] lnlc[r] hdcea[r] adpman[c] datp[c] itp[c] paps[c] pap[c] pi[c] nadh[r] m3gacpail_prot_hs[r] m3gacpail_prot_hs[c] m3gacpail_prot_hs[e] atp[c] pi[c] pi[g] adp[g] gdpfuc[g] & h[c] pectingchol[e] h[r] nadh[r] atp[c] atp[c] nadp[c] & nadph[r] nadp[r] nad[r] h2o[g] adp[c] nadh[r] emem2gacpail_hs[r] & gpi_hs[r] & gpi_prot_hs[r] & dgpi_prot_hs[r] odecoa[r] h[g] cmp[g] fucacngal14acglcgalgluside_hs[e] kdn[c] kdn[e] gluside_hs[e] & o2[c] 5HPET[c] 5HPET[r] o2[r] h[r] h2o[r] h[r] M01075[r] & fuc_L[c] & gluside_hs[g] ca2[c] ca2[e] h2o[c] pi[c] ile_L[c] lys_L[c] thr_L[c] pro_L[c] arg_L[c] val_L[c] trp_L[c] leu_L[c] asp_L[c] leu_L[c] his_L[c] arg_L[c] bildglcur[e] pe_hs[r] man[c] & acglcgalgluside_hs[g] & gal14acglcgalgluside_hs[g] & acngal14acglcgalgluside_hs[g] nadph[c] h[c] h2o[c] atp[g] not in map h[r] & nad[r] nadph[r] acald[r] nadh[r] dag_hs[r] dag_hs[r] dag_hs[r] crn[r] crn[c] h[g] & h[r] h[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] h[r] coa[r] pre_prot[r] gpi_sig[r] h2o[r] h[r] hdca[r] udp[g] h[g] & o2[r] h2o[r] h2o[r] na1[c] h[g] udp[g] na1[c] tststerone[c] & whtststerone[c] prgnlone[c] pi[r] galgluside_hs[e] na1[e] 5adtststerones[e] nad[r] o2[r] h[r] dlnlcg[r] & h[c] 12dhchol[c] & 12dhchol[e] h2o[r] h[r] so4[r] nadph[r] nadp[r] nadp[r] h[r] & & & em2emgacpail_prot_hs[r] & dem2emgacpail_prot_hs[r] coa[r] cmpacna[g] & atp[c] adp[c] C05300[e] C05300[c] h[c] & atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] atp[r] udp[g] udp[g] h[r] nadph[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] h2o[r] pe_hs[r] & uacgam[g] ca2[c] & ca2[e] prgnlones[c] prgnlones[r] & prgnlone[r] & 17ahprgnlone[r] & nad[r] nadp[r] h2o[r] pe_hs[r] h2o[c] pi[c] gm2_hs[e] cmp[g] nad[r] nadh[r] odecrn[r] & odecrn[c] nadph[c] & Rtotal2[e] & thcrm_hs[g] & h[g] hco3[e] hco3[c] nadp[c] h2o[c] & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & nadp[c] & phe_L[c] dhea[r] & andrstndn[r] & em3gacpail_hs[r] & em2emgacpail_hs[r] & mem2emgacpail_hs[r] & mem2emgacpail_prot_hs[r] mem2emgacpail_prot_hs[c] mem2emgacpail_prot_hs[e] h[g] h[g] & h[c] gm1_hs[e] acnacngal14acglcgalgluside_hs[g] acnacngal14acglcgalgluside_hs[c] acnacngal14acglcgalgluside_hs[e] dheas[c] dheas[r] & na1[e] galgluside_hs[g] CE1273[c] CE1273[e] h2o2[c] nadph[r] & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & & retinol_9_cis[e] oagd3_hs[g] bvite[e] h2o[c] h2o[c] h2o[r] & 9_cis_retfa[e] bvite[c] so4[r] dolmanp_U[r] dolp_U[r] pre_prot[r] gpi_sig[r] gpi_sig[c] gpi_sig[e] & oagd3_hs[e] oagd3_hs[c] & CE1352[c] whtststerone[e] h[r] nadp[r] dag_hs[r] h[e] & na1[c] na1[e] nadh[r] h2o[r] h[r] adpman[e] man[e] cmpacna[g] udpacgal[g] & & & estradiol[c] & hestratriol[c] & CE5253[c] pe_hs[r] dag_hs[r] dag_hs[r] dag_hs[r] glc_D[c] h2o[e] & dhea[c] h[r] HC02022[r] HC02025[r] M01501[r] M01454[r] M01458[r] HC02023[r] M01464[r] M01468[r] M01494[r] M01510[r] M01485[r] M01489[r] M01476[r] M01491[r] M01461[r] M01484[r] M01456[r] M01457[r] M01498[r] HC02027[r] M01471[r] M01474[r] M01466[r] M01463[r] M01467[r] M01506[r] M01487[r] M01475[r] M01492[r] M01460[r] M01508[r] M01465[r] M01497[r] M01496[r] HC02026[r] M01480[r] M01472[r] M01509[r] M01481[r] M01462[r] M01473[r] M01469[r] M01483[r] M01477[r] M01502[r] M01486[r] M01490[r] M01495[r] M01455[r] M01470[r] M01479[r] M01482[r] HC02020[r] HC02024[r] HC02021[r] & nadh[c] gdp[g] h2o[c] atp[c] h[c] adp[c] pi[c] hco3[e] hco3[c] h[c] nadph[c] h[c] & nad[c] nadp[c] na1[c] na1[e] pap[c] & & pe_hs[r] Rtotal2[e] nadph[c] nadph[c] h2o[c] h[c] & o2[r]for[r] & glc_D[r] glc_D[e] lpchol_hs[c] pchol_hs[c] gd3_hs[e] coa[g] h[g] cmp[g] h[g] udp[g] acgalfucgalacglcgalgluside_hs[g] & fucacgalfucgalacglcgalgluside_hs[g] fucacgalfucgalacglcgalgluside_hs[c] o2[c] tststerone[c] h[r] nadp[r] h[g] udp[g] gdp[g] udp[g] h[g] CE2047[c] CE2047[e] & h[r] Vitamin A metabolism h[c] h[g] udp[g] h[g] & h[c] o2[c] nadp[c] nadph[r] nadph[r] nadp[r] udpglcur[r] m3gacpail_hs[r] & h2o[r] h[c] h2o[c] h[c] & udp[r] cbp[r] & cbp[c] & gm3_hs[g] & gbside_hs[g] gdpfuc[g] h[c] paps[c] tststeroneglc[r] & h[r] & 11_cis_retfa[c] & retinol_cis_11[c] & retinal_11_cis[c] 11_cis_retfa[e] & retinol_cis_11[e] & estrone[c] pap[c] Androgen and estrogen & 6htststerone[e] tststeroneglc[c] nad[r] & & accoa[g] & gdpfuc[g] atp[c] pi[c] trpglupro[c] argglupro[c] proproarg[c] phelyspro[c] prophe[c] trpalapro[c] prolyspro[c] proglulys[c] propropro[c] protrplys[c] prohis[c] hisprolys[c] estrone[r] & estroneglc[r] dolp_U[r] nadh[r] nad[r] pi[r] pi[r] & pi[c] ga2_hs[g] udp[g] udpacgal[g] h2o[c] adp[c] & estrones[c] & estrones[e] paps[c] andrstandn[r] nadh[r] h[r] nad[r] andrstrn[r] andrstrnglc[r] h[e] cmp[g] & & & & ppi[r] ppi[c] hretn[e] hretn[c] h2o[e] & & nadp[c] nadph[c] nadp[c] udp[r] udpglcur[r] udp[r] h[r] & h[r] h[g] h[g] h2o[c] atp[c] h[c] adp[c] pi[c] & & & nadph[c] estradiol[e] nadp[c] & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] & & ppi[r] ppi[r] & oretn[c] 13_cis_oretn[c] h[g] gdp[g] & & & so4[c] hco3[c] hco3[e] nadph[r] & & & & pe_hs[r] dag_hs[r] dolmanp_U[r] dolp_U[r] pe_hs[r] pe_hs[r] CE1617[r] & retinal_cis_9[r] cmpacna[g] udpacgal[g] & & o2[c] h2o[c] nadph[c] whtststerone[c] whtststerone[r] & nadph[r] dolmanp_U[r] & h2o[c] & & adp[c] h[c] cmpacna[g] & fucgalacglcgalgluside_hs[g] fucfucgalacglcgalgluside_hs[g] fucfucgalacglcgalgluside_hs[c] fucfucgalacglcgalgluside_hs[e] ala_L[c] acald[c] pi[c] h2o[c] nadh[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] coa[r] h[r] co2[r] h2o[c] acgal[g] & prgnlone[c] & 17ahprgnlone[c] & udpglcur[r] nadp[c] Rtotal2[e] & & C05298[c] nad[c] nadh[c] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] amp[r] & gd3_hs[g] & & CE2211[c] & CE2211[e] 7dhcdchol[c] & 7dhcdchol[e] & C05301[c] nadp[r] h2o[r] h[r] o2[r] nadph[r] tststerone[r] o2[r] h2o[r] m2gacpail_hs[r] & memgacpail_hs[r] & m2emgacpail_hs[r] & m3emgacpail_hs[r] h2o[r] coa[c] coa[g] gm2_hs[g] h[g] h2o[c] h[c] o2[c] h2o[c] o2[c] nh4[r] nh4[c] udpgal[g] h[c] & h2o[c] dhea[c] & M01075[c] h[c] h[c] atp[c] Rtotal2[c] h[c] nadh[c] & cmp[g] hco3[e] hco3[c] h[c] & h[r] 11_cis_retfa[e] h[g] udpgal[g] & trp_L[c] glu_L[c] arg_L[c] lys_L[c] phe_L[c] trp_L[c] lys_L[c] glu_L[c] lys_L[c] trp_L[c] his_L[c] lys_L[c] amet[c] ahcys[c] o2[c] nadp[c] h[c] nad[c] 6htststerone[c] 6htststerone[r] & h[r] h[r] h2o[c] retfa[e] & retinol[e] & nad[c] dolp_U[r] dolmanp_U[r] retinal[r] o2[c] udpacgal[g] h[c] 5adtststeroneglc[e] & h[r] pail345p_hs[r] dolp_U[r] g6p[r] g6p[c] caro[e] caro[c] o2[c] nadph[c] h[g] cmp[g] & galthcrm_hs[g] CE2934[c] CE2934[e] C05299[c] hco3[e] hco3[c] & & o2[r] h[r] & h[r] h[r] h2o[r] udp[g] h[g] gdp[g] atp[c] & nadph[c] dolp_U[r] & nad[c] & gm2a_hs[g] & h[c] h2o[c] nadh[c] 5adtststerone[r] & & h2o[r] h[r] pi[r] o2[c] & h2o[e] h[e] oagt3_hs[e] oagt3_hs[c] oagt3_hs[g] & gt3_hs[g] h[g] udp[g] h[g] udp[g] & HC02199[e] HC02199[c] nadph[r] h2o[r] h[r] h2o[r] tmndnccoa[r] M01236[r] M00006[r] & & h[r] h2o[r] nadh[r] h[g] udp[g] h[g] udp[g] h2o[g] h2o[c] stcoa[r] lnlncgcoa[r] tdcoa[r] M00004[r] CE5151[r] odecoa[r] M00020[r] M02052[r] M03050[r] M01237[r] vacccoa[r] adrncoa[r] docoscoa[r] M00023[r] CE4843[r] ddcacoa[r] arachdcoa[r] tethex3coa[r] lneldccoa[r] c226coa[r] M00018[r] dcsptn1coa[r] ptdcacoa[r] M00129[r] clpndcoa[r] arachcoa[r] M00343[r] ttccoa[r] nrvnccoa[r] M02112[r] hexccoa[r] lnlncgcoa[r] eicostetcoa[r] tetpent6coa[r] M03047[r] M00123[r] CE5155[r] strdnccoa[r] M00101[r] tettet6coa[r] M01191[r] M02612[r] M00127[r] dlnlcgcoa[r] hpdcacoa[r] M00012[r] M01141[r] HC10784[r] tetpent3coa[r] pmtcoa[r] lnlccoa[r] hdd2coa[r] hdcoa[r] nad[r] nadh[r] nad[r] pi[c] & h[c] fucgalfucgalacglcgalgluside_hs[e] & ahcys[c] udp[r] nadp[r] & dolmanp_U[r] dolmanp_U[r] nadp[r] nad[r] nad[c] & galfucgalacglcgalgluside_hs[g] & fucgalfucgalacglcgalgluside_hs[g] fucgalfucgalacglcgalgluside_hs[c] h2o[c] atp[c] h[c] adp[c] pi[c] na1[c] na1[e] amet[c] h[c] andrstndn[c] udpglcur[r] h[r] nadph[r] nadp[r] nadp[c] nadph[c] CE1617[c] CE1617[e] o2[c] dhcrm_hs[g] gd2_hs[g] gm1_hs[g] ga1_hs[g] & & & h2o[c] andrstrn[e] udp[r] nadph[r] nadp[r] adp[r] & retinal_cis_13[r] nadp[c] h[c] udpacgal[g] & atp[c] h[c] for[r] retinal[r] & retn[r] & & & nadph[c] h2o[c] h2o[c] nadh[c] 5adtststeroneglc[c] 5adtststeroneglc[r] & mgacpail_hs[r] & & h[r] h[r] h2o[g] h[g] HC02200[e] & & C05302[c] h[r] emgacpail_hs[r] & h[g] udp[g] h[g] HC02200[c] udpglcur[r] nad[r] Glycolysis/gluconeogenesis retinol[c] & retinal[c] & retn[c] 13_cis_retn[c] CE5072[c] & CE5072[e] avite2[c] avite2[e] pro_L[c] atp[c] nadph[c] nadp[r] && eandrstrn[r] stcrn[r] & inost[r] atp[r] pi[r] nadph[r] nadh[r] & udp[g] acgagbside_hs[g] acgbgbside_hs[g] uacgam[g] atp[c] & M02761[c] & nadp[r] h2o[r] nadh[c] Rtotal[g] h[g] udp[g] & udp[g] hco3[e] hco3[c] h2o[c] & nad[r] pe_hs[r] dag_hs[r] & nadph[r] nadh[r] h[c] & cmpacna[g] & h[c] estradiolglc[r] & h2o[r] dolp_U[r] Rtotal2coa[c] h[g] gm1a_hs[g] h2o[c] h[c] h[c] pa_hs[r] udp[g] galgbside_hs[g] & acglcgalgbside_hs[g] galgalthcrm_hs[g] h[c] nadp[c] nad[c] pail35p_hs[r] & h2o[g] h[g] gdpfuc[g] h[c] & atp[c] nad[r] nadh[r] & h[r] h[r] h[r] 6pgl[r] & 6pgc[r] 6pgc[c] gt1c_hs[g] & gt2_hs[g] h[g] h[g] fuc14galacglcgalgluside_hs[e] h2o[c] atp[c] h[c] adp[c] pi[c] nadh[c] crn[r] h[r] h[g] h[g] gdp[g] fuc14galacglcgalgluside_hs[g] fuc14galacglcgalgluside_hs[c] h[e] h[c] adp[c] coa[r] & & h[c] cmp[g] cl[c] cl[e] pi[c] adp[c] & hestratriol[c] hestratriol[r] & estradiol[r] h2o[r] h[r] dolmanp_U[r] & adp[r] nadh[r] Rtotal2[c] nad[c] phsphings[g] & phcrm_hs[g] udp[g] & gd1b_hs[g] cmp[g] & cmpacna[g] asncyscys[c] hco3[e] adp[c] HC02201[e] andrstrn[c] atp[r] h[r] udpglcur[c] h[g] & HC02201[c] h[c] pi[c] andrstandn[c] & nadp[r] & cmpacna[g] gdpfuc[g] & pi[c] hco3[c] gacpail_hs[r] h2o[r] nadp[r] nad[r] 13_cis_retn[r] h[r] udpgal[g] asncyscys[e] nadp[r] h2o[r] h[r] o2[r] nadph[r] h2o[r] cmp[g] cmp[g] fuc14galacglcgalgluside_hs[c] fuc14galacglcgalgluside_hs[e] CE7090[c] & CE7090[e] nadp[c] crn[r] & & h[c] retinol[e] nadh[c] udp[c] & gd1a_hs[g] & gm1b_hs[g] h[g] adp[c] pi[c] hco3[e] h[c] estriol[c] udp[r] pail_hs[r] pail5p_hs[r] co2[r] co2[c] cmp[g] hco3[e] hco3[c] 17ahprgstrn[c] nadph[c] & & gdp[g] adp[c] andrstndn[e] h2o[c] nadph[r] udpglcur[r] & & & udpglcur[r] sphgn[g] & & & & estriol[r] & retinol[r] & & retinal_cis_13[c] h[g] cmp[g] cmp[g] acngalgbside_hs[g] & C05298[e] o2[r] 13_cis_retnglc[c] 13_cis_retnglc[e] udp[g] h[e] h[c] cl[c] & cl[e] & trpthrglu[c] gluthr[c] thrphearg[c] thrthrarg[c] thrargtyr[c] tyrthr[c] hislysthr[c] thrhishis[c] trpthrtyr[c] protrpthr[c] argprothr[c] arghisthr[c] h2o[c] so4[c] & estriolglc[r] h2o[r] nadph[r] coa[c] pchol_hs[c] VitA gt1b_hs[g] & gdpfuc[g] & na1[e] h[c] C05299[e] & pi[r] gq1c_hs[g] pi[c] & & pi[c] pi[c] atp[c] & udpglcur[r] retinol_9_cis[c] cmp[c] & galfuc12gal14acglcgalgluside_hs[g] galfuc12gal14acglcgalgluside_hs[c] galfuc12gal14acglcgalgluside_hs[e] & & & & C05300[r] & ahandrostanglc[r] & ahandrostan[r] & & strdnc[r] udp[r] udp[r] & cmpacna[g] & h2o[c] atp[c] h[c] argphearg[c] & & C05301[e] & udpglcur[r] h[r] h2o[c] cmpacna[g] h[g] h[g] & & & h[c] ump[c] ump[r] retnglc[r] r5p[r] ru5p_D[r] bhb[e] cmpacna[g] cmpacna[g] & & & argphearg[e] h2o[c] h2o[e] & & atp[c] udp[r] nad[r] nadh[r] ppi[r] coa[r] coa[r] nad[c] & cmpacna[g] & & h[g] & adp[c] h[r] 13_cis_retnglc[r] lpchol_hs[c] Rtotal2[c] acac[e] & & udp[g] gdp[g] lys_L[c] estrone[e] h[c] & for[e] lac_L[e] cmp[g] udp[g] coprost[c] & coprost[e] h[c] udpglcur[c] & udpglcur[r] h2o[r] amp[r] atp[r] ac[e] h[c] h[g] h[g] udp[g] retfa[c] ppa[e] h[g] acgalfuc12gal14acglcgalgluside_hs[g] & fuc12gal14acglcgalgluside_hs[g] h2o[c] h2o[r] h[r] nadph[r] nadp[r] h[r] hdcecrn[r] cmp[g] h[g] h[g] cmp[g] h[g] cmp[g] h[g] gdp[g] cmp[g] h[g] cmp[g] adp[c] na1[c] adp[c] nadp[r] chsterol[r] but[e] h[c] h[g] cmp[g] h[g] cmp[g] h[g] cmp[g] h[g] cmp[g] h[g] cmp[g] cl[e] & cl[c] CE6031[c] estrones[c] estrones[r] & estrone[r] & crn[r] crn[r] s9397 h[g] h[e] trp_L[c] glu_L[c] arg_L[c] phe_L[c] arg_L[c] tyr_L[c] his_L[c] tyr_L[c] trp_L[c] pro_L[c] arg_L[c] his_L[c] crn[r] crn[r] crn[r] crn[r] nadh[c] nadh[c] fucgalgbside_hs[g] acn23acngalgbside_hs[g] acn13acngalgbside_hs[g] acnacngalgbside_hs[g] galacglcgalgbside_hs[g] galgalgalthcrm_hs[g] gdp[g] hco3[c] & & & h[c] gp1c_hs[g] gq1balpha_hs[g] & gt1alpha_hs[g] gt1a_hs[g] gd1c_hs[g] gd1b2_hs[g] h[c] pi[c] so4[r] C05300[r] crn[r] crn[r] gacpail_hs[c] pe_hs[c] dag_hs[c] udpglcur[c] gp1calpha_hs[g] gq1b_hs[g] hco3[c] & & & h[c] & 2hb[e] pyr[e] & fucfuc12gal14acglcgalgluside_hs[g] fucfuc12gal14acglcgalgluside_hs[c] hco3[e] alaasnleu[c] & coa[r] dolmanp_U[c] inost[c] nadp[c] nadph[c] & nadph[c] fucfuc12gal14acglcgalgluside_hs[e] alaasnleu[e] & atp[c] s9395 crn[c] lnlncgcoa[c] coa[r] pail_hs[c] pi[c] & cmp[g] & h[c] & & retinol[c] retnglc[c] ru5p_D[c] & & nad[c] atp[c] adp[c] atp[c] h2o[c] atp[c]andrstrnglc[c] coa[r] coa[r] lnlncgcrn[r] & coa[r] crn[c] r5p[c] & & & andrstandn[e] h[c] stcrn[c] & coa[r] strdnccrn[r] coa[r] dolp_U[c] h[g] h[g] coprost[e] & coprost[c] h2o[c] & atp[c] h2o[c] & retinal_cis_9[c] & nadp[c] Sphingolipid metabolism udpacgal[g] so4[c] crn[c] retfa[e] & & h[e] h2o[c] tmndnccrn[r] arachdcrn[r] & crn[c] HC02020[c] pmtcrn[r] h[c] h2o[c] pi[c] atp[c] amp[c] h[c] h2o[c] udp[g] h[g] h2o[c] M01724[r] crn[r] dlnlcgcrn[r] h2o[c] 2hb[e] 2hb[c] gdpfuc[g] crn[c] crn[r] acac[c] & alaarggly[c] h[c] h2o[c] crn[c] & gdp[g] udp[g] alaarggly[e] thr_L[c] pi[c] & HC02198[c] crn[c] but[c] lac_L[c] ppa[c] 1mncam[c] & h[c] & crn[r] lnlncgcrn[c] crn[r] & & pchol_hs[c] ac[c] & na1[e] na1[c] 1mncam[e] ahandrostanglc[c] crn[r] & & & galacgalfuc12gal14acglcgalgluside_hs[g] & fucgalacgalfuc12gal14acglcgalgluside_hs[g] & acgalfucgalacgalfuc12gal14acglcgalgluside_hs[g] acgalfucgalacgalfuc12gal14acglcgalgluside_hs[c] pi[c] atp[c] dlnlcgcoa[c] hdcecrn[c] h[c] h[e] estroneglc[c] h[c] pi[c] adp[c] & crn[r] atp[c] h2o[c] strdnccrn[c] crn[c] lpchol_hs[c] h[e] h[c] estradiolglc[c] tmndnccrn[c] crn[r] for[c] 2hb[c] pyr[c] h[g] coprost[e] & coprost[c] h[c] h2o[c] bhb[c] h[c] crn[c] & pmtcrn[c] & bhb[e] h[g] adp[c] estriolglc[c] pi[c] eandrstrn[c] M01724[c] adp[c] ahandrostan[c] h[c] dlnlcgcrn[c] 9_cis_retfa[c] 9_cis_retfa[e] alaargcys[c] h2o[c] acac[e] acac[c] alaargcys[e] & h2o[c] pi[c] adp[c] arachdcrn[c] adp[c] adp[c] pi[c] HC02020[e] h2o[c] na1[c] hco3[e] atp[c] & gln_L[c] gln_L[e] h[c] hco3[c] atp[c] adp[c] & HC02198[e] retn[e] atp[c] pi[c] & & atp[c] adp[c] andrstandn[c] retinol_cis_13[c] & retinal_cis_13[c] ser_D[c] cl[c] atp[c] & ser_D[e] & h2o[c] pi[c] & cl[e] trpthrile[c] trpilelys[c] hislysile[c] ileasnhis[c] lystyrile[c] gluilelys[c] ileglnglu[c] ileasp[c] iletrptyr[c] metmetile[c] ileprolys[c] trpiletrp[c] h[c] h[c] h2o[c] coa[c] retnglc[e] & h[c] for[c] & h2o[c] for[e] fucgalgbside_hs[c] & h[c] andrstrnglc[e] na1[e] acn23acngalgbside_hs[c] acn13acngalgbside_hs[c] acnacngalgbside_hs[c] galgalgalthcrm_hs[c] CE1297[c] & CE1297[e] & & & pi[c] nad[c] h[c] gp1calpha_hs[e] gp1calpha_hs[c] gp1c_hs[c] gd1b2_hs[c] acgagbside_hs[c] acgbgbside_hs[c] galacglcgalgbside_hs[c] & & & adp[c] & hco3[c] atp[c] & nadh[c] hco3[e] & & & adp[c] & & & pi[c] adp[c] pi[c] h2o[c] atp[c] pi[c] asp_L[c] met_L[c] tyr_L[c] h[c] & pi[c] h2o[c] acgalfucgalacgalfuc12gal14acglcgalgluside_hs[c] acgalfucgalacgalfuc12gal14acglcgalgluside_hs[e] CE6031[e] estriol[e] h[c] ahandrostanglc[e] atp[c] hdcecrn[e] thr_L[c] trp_L[c] lys_L[c] his_L[c] asn_L[c] lys_L[c] glu_L[c] gln_L[c] tyr_L[c] trp_L[c] pro_L[c] lys_L[c] trp_L[c] estradiolglc[e] adp[c] adp[c] ahandrostan[e] h[c] estroneglc[e] estriolglc[e] adp[c]

pi[c] ile_L[c]

acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs[c] acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs[e]

gd1b2_hs[e] acn23acngalgbside_hs[e] acn13acngalgbside_hs[e] galacglcgalgbside_hs[e] galgalgalthcrm_hs[e] eandrstrn[e] fucgalgbside_hs[e] acnacngalgbside_hs[e]