PTPRN2 Antibody Cat. No.: 15-722

PTPRN2 Antibody

Immunohistochemistry of paraffin-embedded human Immunohistochemistry of paraffin-embedded human mammary cancer using PTPRN2 antibody (15-722) at colon carcinoma using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens). dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human Immunohistochemistry of paraffin-embedded mouse lung cancer using PTPRN2 antibody (15-722) at dilution of pancreas using PTPRN2 antibody (15-722) at dilution of 1:100 (40x lens). 1:100 (40x lens).

Specifications

HOST SPECIES: Rabbit

September 23, 2021 1 https://www.prosci-inc.com/ptprn2-antibody-15-722.html SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 IMMUNOGEN: of human PTPRN2 (NP_570858.2).

TESTED APPLICATIONS: IF, IHC, WB

WB: ,1:500 - 1:2000

APPLICATIONS: IHC: ,1:50 - 1:100

IF: ,1:50 - 1:100

POSITIVE CONTROL: 1) SH-SY5Y

2) SGC-7901

3) Mouse pancreas

4) Rat pancreas

PREDICTED MOLECULAR Observed: 111kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: PTPRN2

Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related ALTERNATE NAMES: protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387

GENE ID: 5799

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

September 23, 2021 2 https://www.prosci-inc.com/ptprn2-antibody-15-722.html This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to BACKGROUND: dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.

ANTIBODIES FOR RESEARCH USE ONLY.

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