Recombinant Human CD40 Protein

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Catalog No.: RP02226 Recombinant

Sequence Information Background

Species Gene ID Swiss Prot This gene is a member of the TNF-receptor superfamily. The encoded protein is a Human 958 P25942 receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T Tags cell-dependent immunoglobulin class switching, memory B cell development, and C-Fc & His germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be Synonyms important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40; Bp50; CDW40; MGC9013; this receptor and serves as a mediator of the signal transduction. The interaction TNFRSF5; p50 of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced Product Information transcript variants of this gene encoding distinct isoforms have been reported.

Source Purification HEK293 cells > 95% by SDS- Basic Information PAGE. Description Endotoxin Recombinant Human CD40 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (CD40(Glu21-Arg193)&mFc(Pro99- Formulation Lys330)) of human CD40 (Accession #) fused with a Fc and His Tag at the C- terminal. . Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 22 % trehalose is added as protectants before lyophilization. Bio-Activity

Reconstitution Storage Reconstitute with deionized water Store the lyophilized protein at -20°C to -80°C for long term. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week. Avoid repeated freeze/thaw cycles.

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www.abclonal.com Validation Data

Recombinant Human CD40 Protein was determined by SDS-PAGE with Coomassie Blue, showing bands at 68 kDa