Bruce A. Barron, MD., Ph.D., MPH

Bruce A. Barron, MD., Ph.D., M.P.H. 11124 Governors Drive Chapel Hill, NC 27517 Email: [email protected]

Education

A.B. Allegheny College, 1955

M.P.H. Yale University, School of Medicine, 1960

Ph. D. Yale University, 1965

M.D. New York University, School of Medicine, 1971

Clinical Training

1971 – 1972 Intern, Department of Medicine, New York University – Bellevue Medical Center

1972 – 1973 Senior Resident, Department of Obstetrics and Gynecology, New York University-Bellevue Medical Center

1973 – 1974 Chief Resident and Clinical Instructor in Obstetrics and Gynecology, New York University – Bellevue Medical Center

Academic Appointments

1955 – 1956 Teaching Fellow in Zoology, Dartmouth College, Hanover, New Hampshire

1959 – 1960 Fellow in Public Health, Yale University, School of Medicine, New Haven, Connecticut

1960 – 1965 Fellow in Biometry, Graduate School, Yale University, New Haven, Connecticut

1965 – 1967 Research Associate, The Rockefeller University, New York

1967 – 1974 Assistant Professor, The Rockefeller University, New York

1974 – 1995 Associate Professor, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York

1995 – 1997 Professor, Department of Obstetrics and Gynecology, New York University, School of Medicine, New York

1998 – 2003 Associate Professor, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York

2005 - Adjunct Professor, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

2006 - Adjunct Professor, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

Professional Experience

2005 – Scientific Advisor, Saffron Technology Inc., Reasearch Triangle Park, North Carolina

1998 – 2003 Attending Physician, Columbia-Presbyterian Medical Center

1996 Senior Medical Director, Empire Blue Cross Blue Shield

1995 – 1997 Senior Attending Physician, New York University Hospital

1995 – 1999 Chairman, Section of Obstetrics and Gynecology, The New York Academy of Medicine

1991 – 1995 President, Columbia-Presbyterian Health Services, Inc.

1993 – 1995 Secretary, Section of Obstetrics and Gynecology, The New York Academy of Medicine

1993 – 2004 Chairman, Editorial Committee, Physician’s Reference Guide: Obstetrics and Gynecology

1993 – 1996 Consultant, Empire Blue Cross Blue Shield

1992 – 2003 Adjunct Professor, The Rockefeller University

1991 – 1994 Member, Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University

1988 - Advisor, The Hettinger Foundation

1980 – 1986 Vice Chairman, Board of Directors, The Health and Hospitals Corporation of the City of New York

1980 – 1986 Vice Chairman, Board of Directors Executive Committee, the Health and Hospitals Corporation of the City of New York

1980 – 1986 Chairman, Committee on Medical and Professional Affairs of the Board of Directors, the Health and Hospitals Corporation of the City of New York

1979 – 1995 Member, Doctoral Program Subcommittee of Biostatistics, Division of Biostatistics, School of Public Health of Columbia University

1979 – 1992 Member, Special Study Section, Fogarty Center, National Institutes of Health, Bethesda, Maryland

1975 Board Certified, American Board of Obstetrics and Gynecology

1975 – 1993 Chairman, Committee on Computer Development for Medical Applications, The Presbyterian Hospital, Columbia- Presbyterian Medical Center

1974 – 1995 Associate Attending Physician, The Presbyterian Hospital in the City of New York

1972 Diplomat, National Board of Medical Examiners

1969 – 1974 Advisor, Division of Reproductive Biology, The Ford Foundation

1969 – 1972 Vice Chairman, Division of Computer Sciences, New York Academy of Sciences

1968 Visiting Lecturer, Albert Einstein College of Medicine, Bronx, New York

1966 – 1974 Advisor, Biomedical Division, the Population Council, New York, Nerw York

1957 – 1959 Biochemist/Soldier, United States Army, Department of Medicine, Walter Reed Army Institute of Research,

3 1956 – 1957 Research Assistant, Fourth Surgical Division, New York University-Bellevue Medical Center

Association Membership

Biometric Society, American Statistical Association, Institute of Mathematical Statistics, American Association for the Advancement of Sciences, American Public Health Association, Society of Sigma Xi, Harvey Society, New York Academy of Sciences (Fellow), Bellevue Obstetrical and Gynecological Society, American College of Obstetricians and Gynecologists (Fellow), New York Obstetrical Society (Fellow), Society of Gynecologic Investigation, New York Academy of Medicine (Fellow), American Association of Gynecologic Laparoscopy, The Society of Laparoscopic Surgeons

Grants Held

1988 – 2002 The Hettinger Foundation

1967 – 1982 National Cancer Institute

1975 – 1978 American Cancer Society

1965 – 1971 The Population Council

Elaboration of Experience

1965 – 1974 Advisor to the Biomedical Division of The Population Council

During this period, I was an advisor to the Population Council. In that role, I was involved in the planning and development of research projects in addition to the implementation of operational programs dealing with family planning, sexually transmitted diseases and gynecologic cancer. These investigations were carried out in many countries. I interacted with government officials from the United States as well as those from the countries involved. I was Co-Director of a program in the Eastern Caribbean involving the longitudinal follow-up of more than 20,000 women for a period of ten years. That study was concerned with the introduction of a combined family planning and cervical cancer screening program in that region.

1966 – 1972 International Collaborative Study of Nephrotic Syndrome

I was asked by the Welcome Trust, the funding agency for this clinical investigation, to participate as the statistician for this study while at

4 the Rockefeller University. I was responsible for the experimental design and subsequently supervised data collection and analysis for this multi-center drug trial of Azothioprine in children with nephrotic syndrome. The investigation included participants from the United Sates, England, Scotland, France, Brazil, Canada, Holland and Italy. I coordinated the data collection process and worked with the researchers involved from each of these centers.

1974 – 1995 Attending Physician at the Columbia-Presbyterian Medical Center

From 1974 to 1994, I was in full-time private practice in gynecology based at the Columbia-Presbyterian Medical Center. During that time, I had approximately 4,000 annual patient visits and performed 250 surgical procedures each year, including abdominal, vaginal and endoscopic procedures. From 1978 to 1983, I was responsible for the mortality and morbidity conference on the service. After I was appointed President of Columbia-Presbyterian Health Services, I reduced my private practice activities. During my tenure as President, I saw approximately 3,000 patients annually and performed approximately 300 surgical procedures a year.

1980 – 1989 Advisor on Medical Affairs to Edward I. Koch, Mayor of the City of New York

During the interval 1980 – 1989, I was an advisor to the Mayor on matters dealing with health issues in the City. From 1980- 1987, I was Vice Chairman of the Board of Directors of the Health and Hospitals Corporation of the City of New York. During this period, I chaired the Committee of the Board responsible for the medical affairs within the corporation. The HHC had an annual budget of 2.6 billion dollars and operated 16 hospitals with more than 10,000 beds, providing in-patient and outpatient care to more than 1.5 million people annually. The Corporation had operational contractual agreements with the five medical schools that provided medical staffing in many of the in-patient facilities as well as outpatient clinics. In addition to my role as Director of the Board of this Corporation, I provided advice to the Mayor concerning government policy on issues of health care and was involved in the screening and selection of members of the Administration, such as the Commissioners of Health and Mental Health.

1992 – 1995 Adjunct Professor at the Rockefeller University

For four years, I taught a one-semester course on the introduction to methods of data analysis in biology and medicine to Ph.D. candidates, post-doctoral Fellows and junior faculty at the Rockefeller University. This

5 course provided an introduction to statistical analysis and the use of existing software for the analysis of data collected in the laboratory as well as in clinical studies. In addition, the development of mathematical models of biological systems was discussed. I am currently using the material presented in this course in the preparation of a textbook on Data Analysis in Biology and Medicine.

1991 – 1995 President of Columbia-Presbyterian Health Services, Inc.

I was appointed President of Columbia-Presbyterian health services on January 1, 1991. Columbia-Presbyterian Health Services was the for-profit subsidiary of The Presbyterian Hospital. Its mission was to develop programs with the potential to generate revenue for the hospital and/or enhance the ability of the hospital to enlarge its patient base. To this end, we initiated two projects in 1994. We established a partnership with PepsiCo World Trade and The Fund for Large Enterprises in Russia and opened an ambulatory care facility in Moscow; and developed plans to expand this program to additional sites in Eastern Europe and the former Soviet Union including St. Petersburg, Prague, Warsaw and Budapest. In addition, we initiated discussions with the Peking Union Medical College for the establishment of similar facilities in Beijing and Shanghai. We also completed and had approved a certificate of need application for the establishment of a freestanding birthing center in Manhattan to be marketed to the managed care programs in New York City.

1995 – 1998 Senior Medical Director for Policy, Empire Blue Cross Blue Shield

This organization is a not for profit health insurance company that provides coverage for approximately five million residents of New York State. In this position, I was responsible for developing regional facilities at academic medical centers for the provision of care for patients requiring organ, bone marrow or stem cell transplantation, high risk obstetrical care, treatment for HIV/AIDS, high risk neonatal care and neurosurgery.

1995 – 1997 Professor and Vice Chairman, Department of Obstetrics and Gynecology, New York University School of Medicine

As Vice Chairman of this department, I was in charge of strategic planning and program development. I prepared a plan to provide facilities for the provision of obstetrical care to women determined to be at high risk for complications of pregnancy and to infertile couples that required assisted reproductive technologies.

1998 – 2003 Associate Professor, Department of Obstetrics and Gynecology at the Columbia Presbyterian Medical Center

During this period, together with Mr. J. Richard Smith, Director of Gynecologic Oncology at the Chelsea and Westminster Medical School in London, I have completed two monographs, which have been published by Oxford Health Press. I also completed a book published by the Times Books division of Random House that deals with managed care. I was involved in the marketing of this work including television and radio appearances as well as at bookstores and other sites as organized by the publicity group at Random House.

Publications

Barron, B.A., American Health Care Insurance - A Flawed Business Model, Commentary, (In Press)

Barron, B.A. A study of the properties of two stochastic models of human interaction. (In preparation.)

Barron, B.A. Statistical properties of indices of risk. (Submitted for publication.)

Smith, J. Richard, Naomi Low-Beer, Bruce A. Barron, (2002) HIV Infection in Obstetrics and Gynecology, Health Press, Oxford, England.

Barron, B.A. (1999) Outsmarting Managed Care, Times Books, Random House, New York.

Barron, B.A. (1997) The Price of Managed Care, Commentary, 5, 97:49 – 52.

Smith, J. Richard, Barron, B.A. (1997) A primer on Gynecologic Oncology, Health Press, Oxford, England.

Petrie, R. H., Yeh, S., Barron, B.A., Gai, M. and Xu, L. (1993) Dose/response effect of Meperidine on uterine activity. Journal of Maternal Fetal Medicine 2, 3:159-164.

Nuovo, M.A., Nuovo, G.J., McCaffrey, R.M., Levine, R.U., Barron, B.A. and Winkler, B. (1989). Endometrial polyps in post-menopausal patients receiving Tamoxifen. International Journal of Gynecologic Pathology I, 125 – 131.

7 Crum, C.P., Egawa, K., Barron, B.A., Fenoglio, C.M., Levine, R.U., and Richart, R.M. (1983) Human papilloma virus infection of the cervix and cervical intraepithelial neoplasia: a histopathologic and statistical analysis, Gynecologic Oncology 15, 88.

Crum, C.P., Egawa, K., Fu, Y.S., Barron, B.A., Levine, R.U., Fenoglio, C.M., and Richart, R.M. (1983) Atypical immature metaplasia (AIM): A subset of human papilloma virus infection of the cervix. Cancer 51, 2214.

Yeh, M.Y., Barron, B.A., Bracero, L., Murtha, L., Aboulagia, M., and Reilly, K. (1982) Ultrasonic measurement of the femur length as an index of fetal gestational age. American Journal of Obstetrics and Gynecology 144, 5, 519- 522.

Vitel, M., Oster, M.W., Edsall, J.R., and Barron, B.A. (1982) Pneumocystic pneumonia in a patient with cervical carcinoma treated with combination chemotherapy. Gynecologic Oncology, 13, 262-264.

Barron, B. A., and Richart, R.M. (1981) Screening protocols for cervical neoplastic disease. Gynecologic Oncology 12, 156-157.

Richart, R.M. and Barron, B.A. (1981) Screening protocols for cervical cancer and cervical intraepithelial neoplasia. Cancer 47, No. 5 Supplement.

Barron, B.A. (1978) Biostatistics. Chapter in Gynecologic Cancer, Williams and Wilkens, Baltimore, pgs. 483-490.

Barron, B.A. (1978) Classification in clinical medicine. Classification Society Bulletin 4, 11-23.

Petrie, R.H., Yeh, S., Murata, Y., Paul, R.H., Hon, E.H., Barron, B.A., and Johnson, R.J. (1978) The effects of drugs on the fetal heart rate variability. American Journal of Obstetrics and Gynecology 130, 294-299.

Barron, B.A., Cahill, M.C., and Richart, R.M. (1978) A statistical model of the natural history of carcinoma-in-situ of the uterine cervix. Gynecologic Oncology 6, 196-205.

Barron, B.A. (1978) Estrogen and endometrial cancer: an unresolved issue. Comprehensive Therapy 4, 3:45-51.

Barron, B.A. (1978) The Association of Cancer of the Breast and Endometrium and the Use of Oral Contraceptives. Controversies in Fertility Control, Harper and Row, 185-193.

8 Barron, B.A. (1978) The statistical association between exogenous estrogen and endometrial cancer – a discussion and review of the problem. Contemporary Ob/Gyn 11, 2:44.

Richart, R.M., Vande Wiele, R.L., Barron, B.A., and Ferenczy, A. (1978) Symposium: Detecting Endometrial Cancer. Contemporary Ob/Gyn 11, 5:104- 136.

Richart, R.M., FU, Y.S., Reagan, J., and Barron, B.A. (1978) The problem of squamous neoplasia in female DES progeny. The American College of Obstetricians and Gynecologists Monograph ―Intrauterine Exposure to Diethystilbesterol in the Human.‖

Barron, B.A. (1977) The effects of misclassification on the estimation of relative risk and other measures of association. Biometrics 33, 414-418.

Barron, B.A. and Localio, S.A. (1976) A statistical note on the association of colorectal cancer and lymphoma. American Journal of Epidemiology 104, 5:517- 522.

Barron, B.A., Richart, R.M. and Weinstein, H. (1976) AN investigation of the intrauterine contraceptive device based on a longitudinal study of a self-selected sample of Barbadian women. American Journal of Obstetrics and Gynecology 124, 7:723-729.

Ory, H.W., Conger, B., Barron, B.A., and Richart, R.M. (1974) The relationship of Type 2 Herpes virus antibodies to cervical neoplasia. Obstetrics and Gynecology 43, 6:901-903.

Localio, S.A., and Barron, B.A. (1973) Abdomino-transsacral resection and anastomosis for mid-rectal cancer. Annals of Surgery 178, 540-546.

Barron, B.A. and Richart, R.M. (1971) An epidemiological study of cervical neoplasia disease based on a self-selected sample of 7,000 women in Barbados, West Indies. Cancer 27, 4:978-986.

Barron, B.A., and Richart, R.M. (1971) An epidemiological study of cervical neoplasia disease based on a self-selected sample of 7,000 women in Barbados, West Indies. Cancer 27, 4:978-986.

Barron, B.A., and Richart, R.M. (1970) A statistical model of the natural history of cervical carcinoma, II. Estimates of the transition time from dysplasia to carcinoma-in-situ. Journal of the National Cancer Institute 45, 1025-1030.

9 Morse, L.I. and Barron, B.A. (1970) Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis, III. The distribution of transferred lymphocytes in pertussis treated and normal mice. Journal of Experimental Medicine 132, 4:663-672.

Abramowicz. M., Arnell, G., Barnett, H., Barron, B.A., Edelman, C., Jr., Cordillo, G., Greifer, I., Hallman, N., Kobaraski, O., and Tiddens, H. (1970) Controlled trial of azathioprine in children with nephritic syndrome. Lancet 1, 959-961.

Barron, B.A., Fischetti, V.A., and Zabriskie, J.B. (1970) Studies on bacteriophage kinetics of multicellular systems; a statistical model for the estimation of burst size per cell in streptococci. Journal of Applied Bacteriology 33, 436-442.

Barron, B.A., Hirsch, J., and Glucksman, M.L. (1970) The construction and calibration of behavioral rating scales. Behavioral Science 15, 3:220-226.

Richart, R.M., and Barron, B.A. (1969) The progression of cervical dysplasia. American Journal of Obstetrics and Gynecology 105, 3:386-393.

Barron, B.A., and Richart, R.M. (1968) A statistical model of the natural history of cervical carcinoma based on a prospective study of 557 cases. Journal of the National Cancer Institute Vol. 41, 6, 1343-1353.

Richart, R.M., and Barron, B.A. (1969) The progression of cervical dysplasia. American Journal of Obstetrics and Gynecology 105, 3:386-393.

Barron, B.A. (1969) Variations on a theme – the evaluation of necessary and unnecessary risks. Toxicology and Applied Pharmacology Supplement 3. 72-76. (Invited paper delivered at the Society of Toxicology conference on ―Evaluation of safety in cosmetics‖, October 27-29, 1968.)

Barron, B.A. (1969) Data analysis – an experiment in statistics. Obstetrics and Gynecology Survey 24, 2:998-1005. (Invited paper delivered at the American Cancer Society conference on ―early Cervical Neoplasia‖, September 13, 1968.

Leer, J.A., Jr., Green, J.L., Heimlich, E.M., Hyde, J.S., Moffet, H.L., Young, G.A., and Barron, B.A. (1969) Corticosteroid treatment in bronchiolitis. American Journal of Disease in Children Vol. 117, 495-593.

Barron, B.A. and Mindlin, R.L. (1969) An index of infant health supervision, I. Pediatrics Vol. 43, 5, 892-894.

10 Barron, B.A., and Richart, R.M. (1968) A statistical model of the natural history of cervical carcinoma based on a prospective study of 557 cases. Journal of the National Cancer Institute Vol. 41, 6, 1343-1353.

Barron, B.A., and Richart, R.M. (1968) A statistical model of the natural history of cervical carcinoma based on a prospective stuffy of 557 cases. Journal of the National cancer Institute Vol. 41, 6, 1343-1353.

Barron, B.A. (1968) Medical applications of the computer. Hospital Practice Part I: Vol. 3, 11, 58-69; Part II: Vol. 3, 12, 47-60.

Vaillant, H.W., Cummins, G.T.M., Richart, R.M., and Barron, B.A. (1968) Insertion of the Lippes loop by nurse-midwives and physicians; a comparative follow-up study. The British Medical Journal Vol. 3, 671-675.

Glucksman, M.L., Hirsch, J., McCully, R.S., Barron, B.A., and Knittle, J.L. (1968) The response of obese patients to weight reduction: a quantitative evaluation of behavior. Psychosomatic Medicine Vol. 30, 4, 359-373.

Fischetti, V.A., Barron, B.A., and Zabriskie, J.B. (1968) Studies of streptococcal bacteriophages, I., Burst size and intracellular growth of Group A and Group C streptococcal bacteriophages. Journal of Experimental Medicine Vol. 127, 475- 489.

Richart, R.M., Lerch, V., and Barron, B.A. (1967) A time-lapse cinematographic study of normal human cervical epithelium, dysplasia, and carcinoma-in-situ in vitro. Journal of the National Cancer Institute Vol. 39, 571577.

Barron, B.A. and Bukantz, S. (1967) The evaluation of new drugs—current FDA regulations and statistical aspects of clinical trials. Archives of Internal Medicine Vol. 119, 6, 547-557.

Barron, B.A., and Richart, R.M. (1967) The intrauterine device and cervical neoplasia: A prospective study of patients with dysplasia. Journal of the American Medical Association Vol. 119, 11, 817-819.

Anscombe, F.J., and Barron, B.A. (1966) Treatment of outlying observations. Journal of Research of the National Bureau of Standards Vol. 70B, 2, 141-147.