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Hilary Arnold Godwin HILARY ARNOLD GODWIN born Hilary Joan Arnold, December 1, 1967 Department of Environmental Health Sciences School of Public Health University of California, Los Angeles 66-062B CHS; BOX 951772 Los Angeles, CA 90095 phone: (310) 794-9112 fax: (310) 794-2106 email: [email protected] EDUCATION NIH Postdoctoral Fellow, Johns Hopkins University School of Medicine, 1994-1996 Ph.D. in Physical Chemistry, Stanford University, 1994. B.S. in Chemistry with Honors, University of Chicago, 1989. PROFESSIONAL EXPERIENCE 2007-present Chair, Environmental Health Sciences Department, University of California at Los Angeles 2006-present Professor, University of California at Los Angeles Environmental Health Sciences Department, School of Public Health 2002-present Howard Hughes Medical Institute (HHMI) Professor 2004-2006 Chair, Department of Chemistry, Northwestern University 2003-2004 Associate Chair, Department of Chemistry, Northwestern University 2002-2004 Dow Chemical Company Research Professor in Chemistry, Northwestern University 2001-2006 Associate Professor, Northwestern University Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology (Joint Appointment) 1996-2001 Assistant Professor, Northwestern University Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology (Joint Appointment since 1998) HONORS & AWARDS Howard Hughes Medical Institute (HHMI) Professor (2002-present) Paul Saltman Award (2001) Camille Dreyfus Teacher-Scholar Award (2000) Alfred P. Sloan Research Fellowship (2000) National Science Foundation CAREER Award (1999) Burroughs Wellcome Fund Toxicology New Investigator Award (1998) Camille and Henry Dreyfus New Faculty Award (1996) National Institutes of Health Postdoctoral Research Fellowship (1994-1996) Stanford Centennial Teaching Assistant Award (1992) National Science Foundation Graduate Research Fellowship (1989-1992) January 24, 2008 Hilary Arnold Godwin Phi Beta Kappa (1989) RESEARCH INTERESTS Metal ions in biological systems: molecular mechanism of lead toxicity; biophysical studies on neurological and hormonal signaling; development of fluorescent sensors for metal ions; toxicogenomics and proteomics; public health impacts of climate change. PUBLICATIONS 1. “(E)-1-Benzyl-3-(1-iodoethylidene)piperidine: Nucleophile Promoted Alkyne-Iminium Ion Cyclizations” Arnold, H; Overman, L.E.; Sharp, M. J.; Witschel, M. C. Organic Syntheses 1992, 70, 111-119. 2. “Heterometallic and Homometallic Ruthenium and Osmium Double Bonds in Metalloporphyrin and Metallotetraazaporphyrin Dimers” Collman, J. P.; Arnold, H. J.; Fitzgerald, J. P.; Weissman, K. J. J. Am. Chem. Soc. 1993, 115, 9309-9310. 3. “Multiple Metal-Metal Bonds in 4d and 5d Metal-Porphyrin Dimers” Collman, J. P.; Arnold, H. J. Acc. Chem. Res. 1993, 26, 586-592. 4. “Delta Bonds and Rotational Barriers in 4d and 5d Metal-Porphyrin Dimers” Collman, J. P.; Arnold, H. J. J. Cluster Science 1994, 5, 37-66. 5. “Heterometallic Mixed Triad Multiple Bonds in Metal-Porphyrin Dimers” Collman, J. P.; Arnold, H. J.; Weissman, K. J.; Burton, J. M. J. Am. Chem. Soc. 1994, 116, 9761- 9762. 6. “A Fluorescent Zinc Sensor Based on Metal Induced Peptide Folding” Godwin, H. A. and Berg, J. M. J. Am. Chem. Soc. 1996, 118, 6514. 7. “Lessons from Zinc-Binding Peptides” Berg, J. M. and Godwin, H. A. Ann. Rev. Biophys. Biomol. Struct. 1997, 26, 357-71. 8. “Magnetic Properties of Group 8 Metal-Metal Bonded Porphyrin and Tetraazaporphyrin Dimers” Godwin, H. A.; Collman, J. P.; Marchon, J.-C.; Maldivi, P.; Yee, G. T.; Conklin, B. J. Inorg. Chem. 1997, 36, 3499-3502. 9. “Lead-Fingers: Pb(II)-Binding to Structural Zinc-Binding Domains Determined Directly By Monitoring Lead-Thiolate Charge Transfer Bands” Payne, J. C.; ter Horst, M. A.; Godwin, H. A. J. Am. Chem. Soc. 1999, 121, 6850-6855. 10. “A Selective, Ratiometric, Fluorescent Sensor for Pb2+” Deo, S.; Godwin, H. A. J. Am. Chem. Soc. 2000, 122, 174-175. 11. “207Pb-1H Two-Dimensional NMR Spectroscopy: A Useful New Tool for Probing Lead(II) Coordination Chemistry” Claudio, E. S.; ter Horst, M. A.; Forde, C. E.; Stern, C.; Zart, M. K.; Godwin, H. A. Inorg. Chem. 2000, 39, 1391-1397. 12. "Calcium Triggers An Intramolecular Association Between The C2 Domains of Synaptotagmin" Garcia, R. A.; Forde, C. A.; Godwin, H. A. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 5883-5888. 13. "High-Yield Expression and Purification of Recombinant Proteins In Bacteria: A Versatile Vector For Overexpression Of Glutathione S-Transferase Fusion Proteins Containing Two Protease Cleavage Sites" Sehgal, B.; Dunn, R.; Hicke, L.; Godwin, H. A. Anal. Biochem. 2000, 281, 232-234. 14. “The Biological Chemistry of Lead” Godwin, H. A. Curr. Opin. Chem. Biol. 2001, 5, 223-227. 15. “Synaptotagmin I is a Molecular Target for Lead” Bouton, C. M. L. S.; Frelin, L. P.; Page 2 of 2 January 24, 2008 Hilary Arnold Godwin Forde, C. E.; Godwin, H. A.; Pevsner, J. J. Neurochem. 2001, 76, 1724-1735. 16. “Fundamental Coordination Chemistry, Environmental Chemistry, and Biochemistry of Lead(II)” Claudio, E. S.; Magyar, J. S.; Godwin, H. A. Prog. Inorg. Chem 2003, 51, 1- 144. 17. “Spectropotentiometric Analysis of Metal Binding to Structural Zinc-Binding Sites: Accounting Quantitatively for pH and Metal Ion Buffering Effects” Magyar, J. S.; Godwin, H. A. Anal. Biochem. 2003, 320, 39-54. 18. “Spectroscopic Determination of the Binding Affinity of Zinc to the DNA-Binding Domains of Nuclear Hormone Receptors” Payne, J. C;. Rous, B. W.; Tenderholt, A. L; Godwin, H. A. Biochemistry, 2003, 42, 14214-14224. 19. “High Metal Concentrations Are Required for Self-association of Synaptotagmin II” García, R. A. and Godwin, H. A. Biophys. J., 2004, 86, 2455-2466, 20. “Color My Nanoworld” McFarland, A. D.; Haynes, C. L.; Van Duyne, R.; Godwin, H. A. J. Chem. Ed. 2004, 81, 544A-544B. 21. “Spectroscopic Determination of the Thermodynamics of Cobalt and Zinc Binding to GATA Proteins” Ghering, A. B.; Shokes, J. E.; Scott, R. A.; Omichinski, J. G.; Godwin, H. A. Biochemistry, 2004, 43, 8346-8355. 22. “Nanopatterning with Lithography” McFarland, A. D.; Haynes, C. L.; Van Duyne, R.; Godwin, H. A. J. Chem. Ed. 2005, 82, 768A-768B 23. “Spectroscopic and Functional Determination of the Interaction of Pb2+ with GATA Proteins” Ghering, A. B.; Jenkins, L. M. M.; Schenck, B. L.; Deo, S.; Mayer, R. A.; Pikaart, M. J.; Omichinski, J. G.; Godwin, H. A. J. Am. Chem. Soc. 2005, 127, 3751- 3759. 24. “Reexamination of Lead(II) Coordination Preferences in Sulfur-Rich Sites: Implications for a Critical Mechanism of Lead Poisoning” Magyar, J. S. ; Weng, T.-C.; Stern, C. M.; Dye, D. F.; Rous, B. W.; Payne, J. C.; Bridgewater, B. M.; Mijovilovich, A.; Parkin, G.; Zaleski, J. M.; Penner-Hahn, J. E.; Godwin, H. A. J. Am. Chem. Soc. 2005, 127, 9495- 9505. 25. “Teaching Undergraduates at the Interface of Chemistry and Biology: Challenges and Opportunities” Godwin, H. A.; Davis, B. L. Nature Chem. Biol. 2005, 1, 176-180. 26. “Preparation of Media and Buffers with Soluble Lead (Pb2+)” Mayer, R. A.; Godwin, H. A. Anal. Biochem. 2006, 356, 142-144. 27. “Characterization of the first N2S(alkylthiolate)lead compound: A model for 3-coordinate lead in biological systems” Andersen, R. J.; diTargani, R. C.; Hancock, R. D.; Stern, C. L.; Goldberg, D. P.; Godwin, H. A. Inorg. Chem. 2006, 45, 16574-6576. 28. “A recombinant courtship pheromone affects sexual receptivity in a plethodontid salamander” Houck, L.; Watts, R.; Arnold, S.; Bowen, K.; Kiemnec, K.; Godwin, H.; Feldhoff, P.; Feldhoff, R. Chem. Senses, in press. 29. Haynes, C.; McFarland, A.; Van Duyne, R.; Godwin, H. Nanoscience and Nanotechnology Module, Materials World Modules; Northwestern University: Evanston, Illinois, in press. PROFILES & RESEARCH HIGHLIGHTS • “Hilary Godwin: Alone in Good Company” Austin, J. Science Next Wave (http://nextwave.sciencemag.org/cgi/content/full/2001/07/11/6?). • “Leading The Fight Against Lead Poisoning” Fellman, M. CrossCurrents (Northwestern Page 3 of 3 January 24, 2008 Hilary Arnold Godwin University Weinberg College of Arts and Sciences), Fall 2001, 6-9. • “Million-Dollar Plums For Teaching Biology” Stokstad, E. Science, 2002, 297, 2190-2191. • “2 College Teachers to Receive $1 Million” Becker, R. Chicago Tribune, September 18, 2002. • “Godwin Receives $1M from Howard Hughes Medical Institute” Northwestern University Observer, Oct. 10, 2002. • “WOW Factor Goes Predoctoral” Wilkinson, S. L. Chem. & Eng. September 30, 2002, 32-33. • “Research on Lead Poisoning Will Send Students Into Communities” Guy, S. Chicago Sun- Times, February 5, 2003. • “Chemistry and Community” Strawn, S. The Daily Northwestern, July 17, 2003. • “’The Frontiers of Inorganic Chemistry’ – A Workshop” Eisenberg, R. Inorg. Chem. 2003, 42, 2479. • “Women Scientists in 2003” Deneen, N. CrossCurrents (Northwestern University Weinberg College of Arts and Sciences), Fall 2003, 10-15. • “Summer Scientists Get Head Start on Freshman Year” Fellman, M. Northwestern University Observer, November 6, 2003. • “College Freshman Get Ahead with Lead” Donovan, J. L. Howard Hughes Medical Institute Bulletin, Spring 2004, 32-33. • “Getting the Lead Out” Jegalian, K. Findings (National Institute of General Medical Sciences), March 2005, 8-13. • “Lead Binding Reexamined” Barry, D. Chem. & Eng. News 2005, 83, 13. • “Faculty Profile: Hilary Godwin – Preventing Children from Being Lead Astray” UCLA Public Health Magazine, June 2007, 12-13. • “Gathering Storm: The Health Effects of Global Climate Change” UCLA Public Health Magazine, November
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