Courtesy Co
Uniformed Services University of the Health Sciences
Board ofRegents Quarterly Meeting
February 2011 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES BOARD OF REGENTS 174th MEETING
February 1, 2011 San Antonio, Texas
CONTENTS
Matters of Information Federal Register: Notice of Partially Closed Meeting ...... 1 Board of Regents ...... 2 Charter ...... 3 Bylaws ...... 4 Meeting Calendar ...... 5 Spring Meeting: May 19-21,2011 Summer Meeting: August 8-9,2011 Fall Meeting: October 24-25, 2011 Winter Meeting: February 6-7,2012 (Proposed)
Opening Comments by the Board ...... 6 Dr. Ronald Blanck
Matters of General Consent Board Meeting Minutes, November 9, 2010 ...... 7 Declaration of Board Actions ...... 8
Board Actions Degree Granting, Graduate Education ...... 9-11 Dr. Charles Rice Faculty Appointment and Promotions, School of Medicine ...... 12 Dr. Charles Rice Faculty Appointments and Promotions, Graduate School of Nursing ...... 13 Dr. Ada Sue Hinshaw Faculty Appointments and Promotions, Postgraduate Dental College ...... 14 Dr. Charles Rice Degree Program Transition, Graduate School of Nursing ...... 15 Dr. Ada Sue Hinshaw Award Nomination ...... : ...... 16 Dr. Charles Rice
President's Report ...... 17 Dr. Charles Rice Tab 1 DEPARTMENT OF DEFENSE
Office of the Secretary
Board of Regents of the Uniformed Services University of the Health Sciences
AGENCY: Department of Defense; Uniformed Services University of the Health Sciences
(USU)
ACTION: Quarterly Meeting Notice
SUMMARY: Under the provisions of the Federal Advisory Committee Act of 1972 (5 U.S.c.,
Appendix, as amended) and the Sunshine in the Government Act of 1976 (5 U.S.c. § 552b, as amended), this notice announces the following meeting of the Board of Regents of the
Uniformed Services University of the Health Sciences.
Name of Committee: Board of Regents of the Uniformed Services University of the Health
Sciences
Date of Meeting: Tuesday, February 1,2011
8:00 a.m. to 10:00 a.m. (Open Session)
10:00 a.m. to 11 :00 a.m. (Closed Session)
Location: U.S. Army Medical Museum, Building 1046,2310 Stanley Road, San Antonio,
Texas 78208.
SUPPLEMENTARY INFORMATION
Purpose of the Meeting: Meetings of the Board of Regents assute that USU operates in the best traditions of academia. An outside Board is necessary for institutional accreditation.
Agenda: The actions that will take place include the approval of minutes from the Board of
Regents Meeting held November 9,2010; recommendations regarding the approval of faculty appointments and promotions in the School of Medicine, the Graduate School of Nursing, and the Postgraduate Dental College; and recommendations regarding the awarding of master's and doctoral degrees in the biomedical sciences and public health. The University President will also present a report. These actions are necessary for the University to pursue its mission, which is to provide outstanding health care practitioners and scientists to the uniformed servIces.
Meeting Accessibility: Pursuant to Federal statute and regulations (5 U.S.c. § 552b, as amended, and 41 CFR §§ 102-3.140 through 102-3.165) and the availability of space, most of the meeting is open to the public. Seating is on a first-come basis. The closed portion of this meeting is authorized by 5 U.S.c. § 552b(c)(6) as the subject matter involves personal and private observations.
Written Statements: Interested persons may submit a written statement for consideration by the Board of Regents. Individuals submitting a written statement must submit their statement to the Designated Federal Officer at the address listed below. If such statement is not received at least 10 calendar days prior to the meeting, it may not be provided to or considered by the
Board of Regents until its next open meeting. The Designated Federal Officer will review all timely submissions with the Board of Regents Chairman and ensure such submissions are provided to Board of Regents Members before the meeting. After reviewing the written comments, submitters may be invited to orally present their issues during the February 2011 meeting or at a future meeting.
FOR FURTHER INFORMATION CONTACT: Janet S. Taylor, Designated Federal
Officer, 4301 Jones Bridge Road, Bethesda, Maryland 20814; telephone 301-295-3066.
Ms. Taylor can also provide base access procedures.
2 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http;/lwww.usuhs.mil
~RD OF REGENTS December 20, 2010
MEMORANDUM FOR PRESIDENT, USU
SUBJECT: Request to Partially Close a Federal Advisory Committee Meeting
Pursuant to 5 U.S.c. § 552b(c) and 41 CFR § 102-3.155, Federal agencies may close or partially close an advisory committee meeting to the public under specific circumstances. This. memorandum requests approval to partially close the Winter Meeting of the Uniformed Services University Board of Regents on February 1,2011.
In accordance with leadership and governance recommendations from the Middle States Commission on Higher Education, which accredits the University at the institutional level, as well as DoDI 5105.45, paragraph 4.1.2, the Board of Regents provides advice to the Department and the University President on academic and administrative matters critical to the successful operation of the University. Discussion at the Winter Meeting concerning academic policies and procedures may involve sensitive personnel information including information protected by the Privacy Act. The provisions of Title 5 U.S.c. § 552b(c)(6) authorize this closure. ~ J --4k. lanet S. Taylor . Designated Federal Officer
COORDINATION: Recommend approval; 5 U.S.c. § 552b(c)(6) applies y[~.0~ Ge~ E. Baker, J.D. General Counsel, USU
ACTION: Approved. A summary of meeting activities shall be prepared and maintained as part of nonpublic Board ~ents files. . . ~LL.e~ Charles L. Rice, M.D. President, USU
cc: George P. Taylor, Jr., M.D. Performing the Duties of Assistant Secretary of Defense for Health Affairs
Learning to Care for 1hose in Harm's Way Tab 2 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
BOARD OF REGENTS February 2011
TITLE TERMEXP
maId R. Blanck, D.O. Chair, BOR June 20, 201: )lleen Conway-Welch, Ph.D., MSN Vice Chair, BaR May 01, 201 :is W. Brawley, M.D. Member, BaR May 01, 201: lile T. Debas, M.D. Member,BOR June 20, 201: ichael M.E. Johns, M.D. Member, BaR June 20, 201: :::n Charles C. Krulak, USMC (Ret) Member, BOR May 01, 201. lwrence S. Lewin Member, BaR May 01, 201 :::nneth P. Moritsugu, M.D., M.P.H. Member,BOR June 20, 201 ail R. Wilensky, Ph.D. Member, BOR June 20, 201 nathan Woodson, M.D. Assistant Secretary of Defense for Health Ex Officio Affairs * b.arles L. Rice, M.D. President, USU Ex Officio ADM Regina M. Benjamin, USPHS Surgeon General of the United States Ex Officio : Gen Charles B. Green, USAF, MC Surgeon General, United States Air Force Ex Officio ADM Adam M. Robinson, MC, USN Surgeon General, United States Navy Ex Officio fG Eric B. Schoomaker, MC, USA Surgeon General, United States Army Ex Officio en Thomas R. Morgan, USMC (Ret) Military Advisor to the Board Advisor arry W. Laughlin, M.D., Ph.D Dean, F. Edward Hebert School of Medicine Advisor da Sue Hinshaw, Ph.D., R.N., F AAN Dean, Graduate School of Nursing Advisor OL Mark A. Melanson, MSC, USA Director, Armed Forces Radiobiology Advisor Research Institute ADM John M. Mateczun, MC, USN Commander, Joint Task Force National Advisor Capital Region Medical raj Gen Byron C. Hepburn, USAF, MC Commander, 59th Medical Wing Advisor [G Carla Hawley-Bowland, MC, USA Commanding General, North Atlantic Advisor Regional Medical Command raj Gen Gerard A. Caron, USAF, DC Commander, 79th Medical Wing Advisor ADM Matthew L. Nathan, MC, USN Commander, National Naval Medical Center Advisor OL Norvell V. Coots, MC, USA Commander, Walter Reed Army Health Care Advisor System 'APT W. Rich Dalton, MC, USN Commander, Defense Medical Readiness Advisor Training Institute )hn E. Baker, J.D. General Counsel, USU Advisor
,G William T. Bester, USA (Ret) Executive Secretary
The Assistant Secretary of Defense for Health Affairs is not a statutory member of the Board of Regents but represents the Secretary of Defense, who is by statute an ex officio member Tab 3 CHARTER BOARD OF REGENTS OF THE UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
1. Committee's Official Designation: The Committee shall be known as the Board of Regents of the Uniformed Services University of the Health Sciences (hereafter referred to as the Board of Regents).
2. Authority: The Secretary of Defense, pursuant to 10 U.S.C. § 2113, the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix, as amended) and 41 CFR § 102-3.50(a) established the Board or Regents.
3. Objectives and Scope of Activities: The Board of Regents shall assist the Secretary of Defense in an advisory capacity in carrying out the Secretary's responsibility to conduct the business of the Uniformed Services University of the Health Sciences (hereafter referred to as the University).
4. Description of Duties: The Board of Regents shall provide advice and recommendations on academic and administrative matters critical to the full accreditation and successful operation of the University.
The Under Secretary of Defense for Personnel and Readiness or designee as determined by DoD policy, is authorized to act upon the advice of the Board of Regents.
5. Agency or Official to Whom the Committee Reports: The Board shall report to the Secretary of Defense through the Under Secretary of Defense for Personnel and Readiness.
6. Support: The Department of Defense, through the University, shall provide support as deemed necessary for performance of the Board of Regents functions, and shall ensure compliance with the requirements of the Federal Advisory Committee Act of 1972 and the Government in the Sunshine Act of 1976 (5 U.S.C. § 552b).
Additional information and assistance, as required, may be obtained from other DoD Components with contracting authority, support contractors, including DoD Federally Funded Research and Development Centers for studies and analYSis support.
7. Estimated Annual Operating Costs and Staff Years: It is estimated that the annual operating costs, to include travel costs and meeting and contract support is approximately $250,000.00. The estimated annual personnel costs to the Department of Defense are 2.0 full-time equivalents (FTE).
1 8. Designated Federal Officer: The Designated Federal Officer, pursuant to 000 policy, shall be a full-time or permanent part-time 000 employee, and shall be appointed in accordance with established 000 policies and procedures.
In addition, the Designated Federal Officer is required to be in attendance at all meetings, however, in the absence of the Designated Federal Officer, the Alternate Designated Federal Officer shall attend the meeting.
9. Estimated Number and Freguency of Meetings: The Board or Regents shall meet at the call of the Board's Designated Federal Officer, in consultation with the Chairman and the president of the University. The estimated number of meetings is four per year.
10. Duration: Pursuant to 10 U.S.C. § 2113a, the need for this advisory function is on a continuing basis, however, it is subject to renewal every two years
11. Termination: The Board of Regents shall terminate upon completion of its mission or two years from the date this charter is filed, whichever is sooner, unless the Secretary of Defense or designee extends it.
12. Membership and Designation: Pursuant to 10 U.S.C. § 2113a, the Board of Regents is composed of fifteen members.
• Nine persons outstanding in the field of health care, higher education administration, or public policy shall be apPointed from civilian life by the Secretary of Defense;
• The Secretary of Defense, or his designee, who shall be an ex officio member;
• The surgeons general of the Uniformed Services, who shall be ex officio members;
• The President of the University, who shall be a non-voting ex officio member.
The terms of office for each member of the Board (other than ex officio members) shall be six years except that:
• Any member appointed to fill a vacancy occurring before the expiration of the term for which his predecessor was appointed shall be appointed for the remainder of such term; and
• Any member whose term of office has expired shall continue to serve until his successor is appointed
2 One of the appointed members of the Board shall be designated as Chairman by the Secretary of Defense and shall be the presiding officer of the Board.
The Board members shall be appointed by the Secretary of Defense, and their appointments will be renewed on an annual basis. Those members, who are not full time federal officers or employees, shall be appointed as experts and consultants under the authority of 5 U.S.C. § 3109, and serve as special government employees. Pursuant to 10 U.S.C. § 2113, these special government employees shall be entitled to receive compensation at a rate fixed by the Secretary of Defense, in addition to travel expenses and per diem while serving away from their place of residence.
13. Subcommittees: With DoD approval, the Board of Regents is authorized to establish subcommittees or working groups, as necessary and consistent with its mission and these subcommittees or working groups shall operate under the provisions of the Federal Advisory Committee Act of 1972, the Government in the Sunshine Act of 1976 (5 U.S.C. § 552B, as amended), and other appropriate federal regulations.
Such subcommittees or workgroups shall not work independently of the chartered Board of Regents, and shall report all their recommendations and advice to the Board of Regents for full deliberation and discussion. Subcommittees or workgroups have no authority to make decisions on behalf of the chartered Board of Regents nor can they report directly to the Department of Defense or any federal officers or employees who are not Board of Regents members.
14. Recordkeeping: The records of the Board of Regents and its subcommittees shall be handled according to section 2, General Record Schedule 26 and appropriate Department of Defense policies and procedures. These records shall be available for public inspection and copying, subject to the Freedom of Information Act of 1966 (5 U.S.C. § 552, as amended).
15. Filing Date: April 4, 2009
16. Modified: January 5, 2010
3 Tab 4 Bylaws of the Board of Regents for the Uniformed Services University of the Health Sciences
Article I
Establishment. The Board of Regents for the Uniformed Services University of the Health Sciences (USU), hereinafter the Board, is established by 10 U.S. Code § 2113.
Description. The Board is a federal advisory committee within the Department of Defense and operates in accordance with the Federal Advisory Committee Act (FACA), DoD Instruction 5105.04, "Federal Advisory Committee Management Program," DoD Directives and Instructions specifically and generally applicable to USU, and its Charter.
Article II
Purpose.
A. The purpose of the Board shall be to provide advice and guidance to the Secretary of Defense; the Under Secretary of Defense for Personnel and Readiness; the Assistant Secretary of Defense for Health Affairs; the Director, TRICARE Management Activity; and the USU President in order to ensure that the operation ofUSU is effective, in compliance with all applicable accreditation standards, and in the best traditions of academia.
B. The purpose of these Bylaws is to set forth the organization of the Board and to outline the procedures it uses to accomplish its responsibilities as an advisory committee.
Article III
Members. Pursuant to 10 U.S. Code § 2113, the Board shall consist of:
A. Nine Members, outstanding in the fields of health and health education, who shall be appointed from civilian life by the Secretary of Defense;
B. The Secretary of Defense, or the Secretary's designee, who shall be an ex-officio Member; C. The Surgeons General of the Uniformed Services who shaH be ex-officio Members; and
D. The USU President, who shaII be a nonvoting ex-officio Member.
Representatives. Individual Members of the Board, to include the designee of the Secretary of Defense, may be represented at meetings of the Board and at committee meetings by representatives, provided these representatives are Federal government employees or members of the Armed Services and provided they are appointed in advance and in writing. Representatives should be appointed with continuity in mind and should have authority to speak for the represented Members.
Term of Office. The term of office for each Member of the Board (other than an ex officio Member) shaII be six years except that:
A. Any Member of the Board appointed to fiII a vacancy occurring before the expiration of the term for which a predecessor was appointed, shaII be appointed for the remainder of such term.
B. Any Member of the Board whose term of office has expired shaH continue to serve until a successor is appointed. These appointments will be renewed annuaIIy on the anniversary of the original appointment date.
Appointment of Chair. One of the Members of the Board (other than an ex-officio Member) shaH be designated by the Secretary of Defense as Chair and shall be the Presiding Officer of the Board. The term of the Chair shaII continue until a successor is appointed.
Selection of Vice-Chair. The Chair of the Board shaII select an appointed Member of the Board to serve as Vice Chair.
Article IV
Duties and Responsibilities. The Board shaII:
A. Advise the Secretary of Defense, through the Assistant Secretary of Defense for Health Affairs and the Under Secretary of Defense for Personnel and Readiness, regarding the appointment of the USU President and advise the USU President regarding the appointments of deans ofUSU schools, directors ofUSU institutes, and department chairs within schools and institutes;
B. Be informed by the USU President of appointments of associate deans and assistant deans;
2 C. Advise the USU President on the awarding of appropriate academic degrees to successful candidates - after first receiving and considering the recommendations of the faculty and deans ofUSU schools;
D. Advise the USU President on the conferring of Honors (to include Professor Emeritus, Senior Lecturer, and Distinguished Professor) and honorary degrees - after first receiving and considering the recommendations of the deans ofUSU schools;
E. Provide its advice on policies and procedures intended to ensure that USU maintains appropriate accreditation requirements;
F. Consider recommendations made by USU Committees on Appointments, Promotion, and Tenure and provide its advice on these recommendations to the USU President;
G. Consider recommendations made to establish new academic programs at USU. (Recommendations for new programs will be read into the minutes at the Board meeting when they are first presented. Advice on whether or not to approve new programs will ordinarily be provided to the USU President at the next regularly scheduled Board meeting.); and
H. Perform other duties as deemed appropriate and within its Charter, to include (1) assessing and providing advice to the Assistant Secretary of Defense for Health Affairs, the Under Secretary of Defense for Personnel and Readiness, and the Secretary of Defense on the performance of the USU President; the performance ofUSU as an institution (including major academic programs and divisions); the well-being ofUSU faculty, students, and staff; the adequacy ofUSU financial resources and their management; and the adequacy ofUSU's physical facilities; and (2) serving as an advocate for USU and its needs.
Article V
Advisors. Advisors to the Board shall include:
A. USU deans;
B. Commanders of affiliated teaching hospitals;
C. A legal advisor (the USU General Counsel);
D. A military advisor to provide advice to the Board from an operational perspective; and
E. Other individuals invited by the Board to serve in this capacity.
3 Article VI
Committees.
A. Executive Committee of the Board
1. Designation: The Board shall designate an Executive Committee. The Executive Committee shall report to the Board.
2. Purpose: The Executive Committee shall be responsible for conducting the business of the Board between its meetings. Recommendations made by the Executive Committee shall be submitted for ratification at the next regularly scheduled meeting of the Board
3. Membership:
(a) Chair, Board of Regents (chair); (b) Vice Chair, Board of Regents (vice chair); (c) An appointed Member of the Board selected by the Board; (d) An ex-officio Member of the Board selected by the Board; and, (e) USU President (non-voting)
4. Meetings: The Executive Committee of the Board shall meet either at the call of the chair of the Executive Committee or at the request of any two members of the Executive Committee other than the chair of the committee. Meetings may be held in person or via conference call.
B. Ad Hoc Committees
1. Designation: The Board of Regents, as a body, shall designate ad hoc committees as necessary.
2. Purpose: Each ad hoc committee shall be responsible for in-depth consideration of assigned Board agenda items and/or special projects between scheduled meetings.
3. Membership: The Chair of the Board of Regents shall appoint ad hoc committee members and designate their chairs. Ordinarily, at least one appointed Member of the Board and at least one ex-officio Member of the Board will be appointed to each ad hoc committee.
4. Meetings: Each ad hoc committee shall meet either at the call of its chair, or at the request of any two members other than the chair. Meetings may be held in person or via conference call.
4 Article VII
Awards.
A. Board of Regents Awards: The Board shall annually recognize three outstanding students selected by the Dean, School of Medicine; the Dean, Graduate School of Nursing; and the Associate Dean, Graduate Education in accordance with separately established criteria.
B. Carol J. Johns, M.D. Medal: The Board shall review and approve or disapprove the Carol J. Johns, M.D. Medal recognizing an outstanding faculty member selected by the Faculty Senate in accordance with separately established criteria.
C. Distinguished Service Awards, Exceptional Service Awards, and the University Medal: The Board shall review and approve or disapprove Distinguished Service and Exceptional Service Awards and the University Medal.
Article VIII
General Procedures.
A. Regular Meetings: The Board shall hold at least four (4) meetings in an annual period from October 1 to September 30, or more often if the Secretary of Defense, the designee of the Secretary of Defense, or the Chair of the Board of Regents shall deem it necessary. Unless otherwise determined by the Board, meetings shall be held in the Board of Regents Conference Room at the University, 4301 Jones Bridge Road, Bethesda, MD 20814.
B. Additional Meetings: Additional meetings shall be called by the Designated Federal Officer of the Board upon the direction of the Chair of the Board of Regents, the USU President, or upon written request of three or more Members of the Board. Additional meetings of the Board shall be held at such times and places as shall be specified in the notice of the meeting.
C. Notice of Meetings:
1. Notice of all meetings of the Board shall be sent by the Designated Federal Officer to each Member of the Board by mail, fax, electronic mail or telephone.
2. The Designated Federal Officer shall mail a notice not less than fifteen (15) days before any regular meeting. Faxing, emailing, or telephoning a notice shall be done not less than seven (7) days before a regular meeting.
3. The recital by the Executive Secretary in the minutes that notice was given shall be sufficient evidence of the fact.
5 4. Public announcement of the meetings of the Board shall appear in the Federal Register as provided in the Government in the Sunshine Act. (5 U.S.C. 552b(e)(3))
D. Closure of Meetings: Meetings of the Board shall be open to the public unless a written determination is made to close all or part of a meeting in coordination with General Counsel. The determination shall cite those provisions of 5 U.S.C. 552b( c)(1) that justify closure and a summary of meeting activities shall be prepared and maintained as part of nonpublic Board of Regents' files.
E. Quorum: The presence of a majority of all Members of the Board will constitute a quorum of the Board. When there are no vacancies on the Board, a quorum means at least eight (8) Members must be present in person or via electronic means. A Member's duly designated representative, provided the designation includes a proxy, counts for purposes of a quorum.
F. Voting:
1. During a meeting, if a quorum is called for by a member and found not to be present, no further business may be transacted.
2. During a meeting, issues will be determined by voice balloting, unless an individual Member of the Board of Regents requires a written ballot.
3. The Chair, Board of Regents, is a Member ofthe voting assembly and has the same right to vote as any other Member when the vote is by ballot.
4. Unless otherwise specified, a simple majority vote will determine matters of issue before the Board. In the event of a tie vote, the proposed resolution is lost.
5. At the direction of the Chair, Board of Regents, action may also be taken by a majority of the Members by notation voting (that is to say by voting on material circulated to the Members individually or serially, or by polling of Members individually or collectively by mail, telephone, fax, email or a similar procedure). Such action will be reported by the Executive Secretary at the next meeting of the Board.
6. The Secretary of Defense, or the Secretary's designee, or a duly appointed representative of the Secretary's designee is authorized to vote.
7. The Surgeons General of the Uniformed Services, or their duly appointed representatives, are authorized to vote.
8. The USU President (Dean ofthe University) is precluded by statute from voting.
6 9. Except for the USU President, individual Members of the Board, to include the designee of the Secretary of Defense, may give proxies to their representatives or to other Members of the Board of Regents (allowing them to be counted for quorum purposes and to vote) provided this is done in advance and in writing.
G. Order of Business: The order of business will be at the discretion of the Chair, Board of Regents, unless otherwise specified by the Board.
H. Rules of Order: The rules contained in the current edition of Robert's Rules of Order Newly Revised shall govern the Board in all cases in which they are applicable and in which they are not inconsistent with applicable statutes and directives, these Bylaws, and any special rules the Board may adopt.
Article IX
Amendment and Effective Date.
A. Amendment: These Bylaws may be amended at any meeting of the Board as long as each proposed amendment has been provided to the Members at least 60 days before the next scheduled meeting. Amendments will take effect by the affirmative vote of two-thirds (2/3) of the Members present.
B. Effective Date: These Bylaws are effective May 16,2008, and supersede previously published Bylaws dated August 7,2007.
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.. Opening Comments by the Chair
• Jonathan Woodson, M.D., confirmed by the United States Senate as Assistant Secretary of Defense for Health Affairs o Sworn in January 10,2011 o Short biography (Attachment 1)
• Status report, five year comprehensive evaluation, USU President o Contract awarded to the Association of Governing Boards of Universities and Colleges (AGB) in December 2010 o Consultant selected and work has begun o AGB process overview (Attachment 2)
• USU's mission, vision and guiding principles (Attachment 3)
February 2011 Attachment j
Dr. Jonathan Woodson Takes Oath to Become Assistant Secretary of Defense for Health Affairs
Health Affairs
January 10,2011
Dr. Jonathan Woodson took the oath ofoffice Jan. 10, 2011 to become the next assistant secretmy ofdefense for Health A/fairs and director, TRICARE Management Activity.
Dr. Jonathan Woodson took the oath of office today to become the next assistant secretary of Defense for Health Affairs and director, TRICARE Management Activity. Dr. Woodson was nominated by President Obama in April 2010 and recently confirmed by the United States Senate.
As assistant secretary, Woodson will administer the more than $50 billion Military Health System budget and serve as principal advisor to the secretary of Defense for health issues, ensuring the effective execution of the Department of Defense medical mission. He will oversee the development of medical policies, analyses, and recommendations to the secretary of Defense and the undersecretary for PersOlmel and Readiness, and issue guidance to DoD components on medical matters. He will also serve as the principal advisor to the undersecretary for Personnel and Readiness on matters of chemical, biologicaL radiological and nuclear medical defense programs and deployment matters pertaining to force health.
In addition, as assistant secretary, he will co-chair the Armed Services Biomedical Research Evaluation and Management C0l1U11ittee, which facilitates oversight of DoD biomedical research. He will also exercise authority, direction and control over the Uniformed Services University of the Health Sciences; the Armed Forces Radiobiology Research Institute; the Defense Center of Excellence for Psychological Health and Traumatic Brain Injury; the Armed Forces Institute of Pathology; and the Armed Services Blood Program Office.
As director, TRlCARE Management Activity, Woodson will be responsible for managing all TRICARE health and medical resources, and supervising and administering TRICARE medical and dental programs, which serve more than 9.6 million beneficiaries. Woodson will also oversee the TRICARE budget; information technology systems; contracting process; and direct TRICARE regional offices. In addition, he will manage the Defense Health Program and the DoD Unified Medical Program.
Prior to his appointment, Woodson served as associate dean for diversity and multicultural affairs and professor of surgery at the Boston University School of Medicine, and senior attending vascular surgeon at Boston Medical Center. Woodson holds the rank of brigadier general in the U.S. Army Reserve, and served as assistant surgeon general for Reserve Affairs, Force Structure and Mobilization in the Office of the Surgeon General, and as deputy commander of the Army Reserve Medical Command.
Woodson is a graduate of the City College of New York and the New York University School of Medicine. He received his postgraduate medical education at the Massachusetts General Hospital, Harvard Medical School and completed residency training in internal medicine and general and vascular surgery. He is board certified in internal medicine, general surgery, vascular surgery and critical care surgery. He also holds a master's degree in strategic studies (concentration in strategic leadership) from the U.S. Army War College.
In 1992, he was awarded a research fellowship at the Association of American Medical Colleges Health Services Research Institute. He has authored/coauthored a number of publications and book chapters on vascular trauma and outcomes in vascular limb salvage surgery.
His prior military assignments include deployments to Saudi Arabia (Operation Desert Storm), Kosovo, Operation Enduring Freedom and Operation Iraqi Freedom. He has also served as a senior trauma medical officer with the National Disaster Management System, where he responded to the Sept. 11th attack in New York City. Woodson's military awards and decorations include the Legion of Merit, the Bronze Star Medal and the Meritorious Service Medal (with oak leaf cluster).
In 2007, he was named one ofthe top vascular surgeons in Boston, and in 2008 was listed as one of the top surgeons in the U.S. He is the recipient of the 2009 Gold Humanism in Medicine Award from the Association of American Medical Colleges.
Source: http://www.health.mil/default. aspx, January 12, 2011 Attachment.
AGB Consulting Services: Comprehensive Presidential Assessment
One of the key benefits of the comprehensive presidential assessment is that it allows the president to further strengthen their performance. The assessment process ideally builds on any earlier annual assessment reviews and a variety of strategic and operational goals that you have established. Furthermore, it will help to enhance the president's relationship with the governing board, it will encourage the president and board to work in tangent towards mutually agreed upon goals and the process will also help to improve other academic and administrative mechanisms of decision-making.
Comprehensive assessments are generally recommended once a president has been in office for a minimum of three years. The assessment is designed to strengthen the relationship between the president, board and institutional community, and should not be initiated in response to a crisis in confidence or at the time of a public controversy over an event or decision. Nor should it be seen as a way to gain evidence for a termination decision that a board intends to make. AGB will screen for these issues as it works with the institution considering a comprehensive review. Since an effective assessment depends on the full and clear support of the president, board chair and other board leaders, AGB will only provide this service to institutions where there is a healthy relationship and where both the president and board chair are committed to the process.
Should you and the board decide to conduct a comprehensive presidential assessment, we will identify potential consultants who present the best fit based on their experience working with institutions similar to yours and their expertise in conducting a comprehensive assessment. Once the board chair, assessment committee chair, and the president have reviewed the bios, I would recommend that you schedule a conference call with each of the consultants to ascertain the best suited for this assignment. We will work closely with you to assist you with the consultant selection process. Once selected, the consultant will schedule telephone calls with appropriate leadership and the president to discuss the assessment, the specific outcomes and goals of the consulting assignment, your ideal timetable and next steps in the process.
Subsequent to the initial round of conversations with the consultant, AGB will submit a consulting contract that will take into consideration the overall work plan and the preferred timeline, underscored by a clear process that will work toward reviewing and strengthening the work of the institutional leader.
The assessment process normally spans a period of two to four months during which the AGB designated consultant will work with the assessment committee, the president and the board chair to implement a series of specific activities related to the assessment process. While some of the project's planning will likely be conducted by telephone and electronically, the consultant will require a few onsite visits to the institution.
Project consultancies are billed at a rate of $4,500 per day. It is our expectation that the consultancy would run between 7-10 days over a two to four month period. AGB's daily rate covers the fee for consultants and AGB staff expertise and operational support. Travel related expenses are not included in the daily rate, and AGB will submit travel and related expenses to the institution under separate cover. Qualifications: AGB's comprehensive portfolio of service for the boards and chief executives of institutions is nationally recognized. The association has conducted a significant number of consulting projects and board development efforts with private and public institutions and university foundations. AGB's consultants are uniquely qualified to implement this agreement. AGB consultants are engaged by the association as independent contractors. They represent the best thinking and practices related to institution relations.
AGB is a membership organization serving approximately 1800 public and private higher education institutions and 35,000 individual board members, presidents, and senior administrators. Founded over eighty years ago, AGB advances the practice of citizen trusteeship that has distinguished American higher education for more than 350 years. By serving as a continuing-education resource to trustees and boards and by contributing to effective working relationships between boards and chief executives, AGB seeks to strengthen the governance of higher education institutions. By providing education to boards, individual trustees, presidents, and other senior institutional leaders, AGB hopes to enhance institutional oversight and to stimulate cooperation with public-policy makers, government agencies, and private organizations that have a stake in the quality and effe~tive governance of colleges and universities.
AGB works to identify emerging issues of concern to higher education and to promote their visibility by conducting research, developing publications, holding forums for discussion, and by encouraging appropriate member initiatives, whether on individual campuses, in state systems, or across higher education as a whole. Our ultimate goal is to help ensure that higher education remains a strong and vital national asset.
Source: E-mail from Julie Manus, A ( to Jan Taylor, 6/2 J/20 Attachmen
Uniformed Services University of the Health Sciences
Mission
The Uniformed Services University of the Health Sciences is the Nation's federal health sCiences University and is committed to excellence in military medicine and public health during peace and war. We provide the Nation with health professionals dedicated to career service in the Department of Defense, and the United States Public Health Service and with sCientists who serve the common good. We serve the uniformed services and the Nation as an outstanding academic health sciences center with a world wide perspective for education, research, service, and consultation ; we are unique in relating these activities to military medicine, disaster medicine, and military medical readiness.
Vision
We are the Nation's federal health sciences University, recognized as an outstanding scholarly education center. Our component schools and institutes are dedicated to excellence and innovation in education, research, and service worldwide.
We are a University that grants degrees in the health sCiences at all levels, producing outstanding scientists and healthcare practitioners for the Nation.
We are recognized as the preeminent center for the study of military medicine, tropical disease, disaster medicine, and adaptation to extreme environments.
We are a major coordinating center for consultation, support, and advocacy education and operational readiness training in the health sciences throughout the careers of uniformed medical personnel.
We have cooperative, mutually supportive and valued interaction with DoD hospitals that enhances undergraduate education, graduate medical education, research programs and patient care.
We have a partnership with the Henry M. Jackson Foundation for the Advancement of Military Medicine that enriches our scholarship and contributes to our fiscal stability and maximum development.
We attract a diverse population of qualified individuals and encourage their personal and professional development. Our students, faculty and staff appreciate that they are essential to the work and success of each other and the University.
We prepare and inspire our students, faculty and staff for a lifetime of learning, leadership, and service .
Our programs, scholarly activities, faculty and graduates make outstanding contributions throughout the medical and scientific communities.
Guiding Principles
As we strive to accomplish our mission, we are committed to all of the following principles. Each one represents an essential and equally important core value.
Caring We foster an atmosphere of caring, mutual respect, courtesy, pride in work and personal development. Each member of the university community is important.
Communication We interact and share information in a timely manner with openness, candor and sensitivity.
Integrity We conduct ourselves responsibly, ethically and honestly.
Loyalty We are dedicated to each other, the University, the Department of Defense and the Nation.
Quality We strive to excel through continuous quality improvement.
Scholarship We are committed to academic freedom as fundamental to the advancement of knowledge and a lifetime of learning.
Service We are sensitive to the needs of those we serve and are responsive to new ideas and change.
Teamwork We value the contributions of each member of our community and work to achieve an environment characterized by cooperation, collegiality, and an appreciation of diversity.
To provide the Nation with medical officers and scientists of character who serve the common good Tab 7 Minutes of the Board of Regents of the Uniformed Services University of the Health Sciences
Meeting No. 173 November 9, 2010
The Board of Regents of the Unifonned Services University of the Health Sciences met on November 9,2010, at the Unifonned Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland. The meeting date and agenda were published in the Federal Register and each Regent was duly notified prior to the meeting. The Chair called the meeting to order at 8:00 a.m. Members and advisors listed below were in attendance:
Board Members
Ronald R. Blanck, D.O., Chair Colleen Conway-Welch, Ph.D., M.S.N., Vice Chair Otis W. Brawley, M.D., Member Haile T. Debas, M.D., Member Michael M.E. Johns, M.D., Member Lawrence S. Lewin, Member Kenneth P. Moritsugu, M.D., M.P.H., Member Gail R. Wilensky, Ph.D., Member Charles L. Rice, M.D., President, USU Warren Lockette, M.D., representing the Office of Assistant Secretary of Defense for Health Affairs V ADM Adam M. Robinson, MC, USN, Surgeon General, U.S. Navy Lt Gen Charles B. Green, USAF, MC, Surgeon General, U.S. Air Force MG Carla G. Hawley-Bowland, MC, USA, representing the Surgeon General, U.S. Anny RADM Boris D. Lushniak, representing the Surgeon General of the United States
Advisors to the Board
Gen Thomas R. Morgan, USMC (Ret), Military Advisor to the Board Larry W. Laughlin, M.D., Ph.D., Dean, F. Edward Hebert School of Medicine, USU Ada Sue Hinshaw, Ph.D., R.N., F AAN, Dean, Graduate School of Nursing, USU COL Mark A. Melanson, MSC, USA, Director, Anned Forces Radiobiology Research Institute BG Stephen L. Jones, MC, USA, for the Commander, Joint Task Force, National Capital Region Med Maj Gen Gerard A. Caron, USAF, DC, Commander, 79th Medical Wing RADM Matthew L. Nathan, MC, USN, Commander, National Naval Medical Center John E. Baker, J.D., General Counsel, USU
AWARD PRESENTATIONS Following introductory remarks by Dr. Gary Wind, President, USU Faculty Senate, Dr. Blanck and Dr. Rice presented two awards. The university's Exceptional Service Medal was presented to Col Paul Hemmer in recognition of his many contributions to the Faculty Senate and the university from July 1997 to July 2009. Dr. Robert Williams was awarded the Exceptional Service Medal for his contributions to the Faculty Senate. Dr. Williams served in several Senate leadership positions between July 1993 and July 2009. Dr. Patrick Sculley, Senior Vice President for University Programs, Southern Region Office, presented the university's Outstanding Service Medal to Dr. Alan Whittaker, National Defense University, for his work as senior member of the Uniformed Services University of the Health Sciences Internal Review Committee. Dr. Blanck and Dr. Rice presented the university's Exceptional Service Medal to Dr. John Potter for his meritorious service as director of the United States Military Cancer Institute since July 2000.
OPENING COMMENTS Following the introduction of Dr. Warren Lockette, Deputy Assistant Secretary of Defense for Clinical and Program Policy; RADM Boris Lushniak, Deputy Surgeon General of the United States; and Maj Gen Gerard Caron, Commander, 79th Medical Wing; Dr. Blanck briefly reviewed items to be addressed during the closed session. These included an update regarding the Board of Regents Academic Review Subcommittee and a status report concerning the upcoming five year evaluation of the university'S president.
MATTERS OF GENERAL CONSENT Dr. Blanck presented the matters of general consent listed below: • Meeting dates for the coming year, noting that the Winter Meeting will be held January 31-February 1,2011, in San Antonio, Texas • Minutes of the August 3, 2010, Board of Regents Meeting
Upon motion duly made and seconded, the Board Voted by voice vote: To approve the matters of general consent as presented.
PRESIDENT'S REPORT AND A WARD PRESENTATION Dr. Rice included the following items in his report: • USU is no. 84 in a September 2010 listing published by the Chronicle of Higher Education ranking the top 100 university research programs in the United States • The Department of Defense is currently undergoing an organizational assessment as the result of the Secretary's Efficiencies Task Force • An invitation to present an overview of the university at the recent meeting of the Australian Military Medical Association included interest in developing research relationships with USU • With the assistance of outside consultants, the Office of the President continues to conduct comprehensive reviews of the university's senior leadership
Dr. Blanck and Dr. Rice presented Brig Gen (Ret) William Bester the Distinguished Service Medal for his leadership as the acting president of the university from March to September 2010.
2 BOARD ACTIONS Degree Granting - Graduate School of Nursing Dr. Hinshaw presented the names of 29 graduate nursing students from the Nurse Anesthesia Program to receive the degree of Master of Science in Nursing upon successful completion of program requirements. This class is scheduled to complete its program in December 2010 and it is requested that the Dean, Graduate School of Nursing, be authorized to award these degrees.
Upon motion duly made and seconded, the Board Voted by voice vote: To concur with the recommendation as presented by Dr. Hinshaw and to recommend that the degrees be conferred as stated.
Degree Granting - Graduate Education Dr. Metcalf presented for certification four candidates to receive the degree of Doctor of Philosophy and one candidate to receive the degree of Master of Science.
Upon motion duly made and seconded, the Board Voted by voice vote: To concur with the recommendations as presented by Dr. Metcalf and to recommend that the President confer the degrees as stated.
Faculty Appointments and Promotions - Graduate School of Nursing Dr. Hinshaw presented a recommendation made by the Graduate School of Nursing Committee of Appointments, Promotion and Tenure at a meeting on August 26, 2010. The committee recommended that Carol A. Romano, Ph.D., RN, be promoted to the rank of Professor with Tenure.
Upon motion duly made and seconded, the Board Voted by voice vote: To approve the recommendation of the committee as presented by Dr. Hinshaw and to recommend that the President implement the action as stated.
Faculty Appointments and Promotions - School of Medicine Dr. Laughlin presented the recommendations made by the School of Medicine Committee of Appointments, Promotion and Tenure at a meeting on September 1,2010. Twelve individuals were recommended for facuIty appointments, promotions or tenure.
Upon motion duly made and seconded, the Board Voted by voice vote: To approve the recommendations of the committee as presented by Dr. Laughlin and to recommend that the President implement the actions as stated.
Faculty Appointments and Promotions - Postgraduate Dental College Dr. Rice presented the recommendations made by the Air Force Postgraduate Dental School Committee of Appointments, Promotion and Tenure at a meeting on September 1,2010, and at a meeting on October 4,2010. Five individuals were recommended for faculty appointments.
3 Upon motion duly made and seconded, the Board Voted by voice vote: To approve the recommendations of the committee as presented by Dr. Rice and to recommend that the appointments be implemented as stated.
DEANS' REPORTS Graduate School of Nursing Dr. Hinshaw began her report highlighting five new faculty members and briefly describing their areas of expertise. Other items covered included the following: • A revised curriculum has been drafted for the Ph.D. in Nursing Science Program. It is committed to a strong science core and contains three areas of concentration o Bio-behavioral adaptation and rehabilitation o Population health and health promotion o Health systems research and informatics • Work continues toward the implementation of the Doctor of Nursing Practice Program o A detailed curriculum has been developed which emphasizes advanced clinical work and evidence-based practice processes o Transition models are being developed by a team which includes Service representatives • At the request of the Services, an expansion of the university's Psychiatric Mental Health Nurse Practitioner Program is being explored
School of Medicine Dr. Laughlin summarized the school's recently completed strategic plan, which is comprised of five goals, each with related objectives and activities. He thanked Dr. Debas and Dr. Johns for their review and guidance, and invited additional comments from the full Board. Other topics addressed in Dr. Laughlin's report included the following: • Curriculum reform in the School of Medicine o 80 faculty members are currently involved o Primary changes include integrating the basic sciences with clinical experience and small group teaching rather than large lectures
Ensuing discussion included the probable need for new testing procedures; the fact that the new curriculum is space and faculty intensive; the ramifications of educating "on line;" and the fact that military medical education is perhaps unique in its emphasis on population health and biostatistics.
• Recruitment and admissions o Applications continue to increase o Approaches to increase the number of underrepresented minority students include working with Service "enlisted to physician" programs and continuing USU's summer internship program
Several Regents expressed the importance of emphasizing humanitarian assistance efforts and the importance of establishing "pipelines" at the junior high and high school level.
4 • The university's Graduate Education Programs have begun the 2010-2011 academic year. Of the 71 new students enrolled at either the master's or doctoral level, 46 are military officers.
REPORT FROM THE FACULTY Following a review of upcoming events, Dr. Wind's report emphasized the issues below: • Discussion is under way concerning faculty representation in the senate from the Postgraduate Dental College and the Armed Forces Radiobiology Research Institute • The recent pay band increase brings the majority of basic science faculty to, or close to, comparability with other area institutions. The Faculty Senate appreciates Dr. Rice's commitment to this issue as well as the Board's support • Work is beginning on a searchable database to facilitate collaborative research opportunities for clinicians and university scientists • Current concerns include a perceived lack of openness regarding processes in both the Office of Research and in the Office of Finance and Administration
ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE (AFRRI) UPDATE AFRRI is celebrating its 50th anniversary over the next two years. COL Melanson reviewed the list of planned symposia, conferences and ceremonies with the Board.
BOARD COMMITTEE REPORTS Academics Committee Dr. Johns summarized the reports heard by the Academics Committee: • The report from Graduate Medical Education focused on the National Capital Consortium o The consortium has received maximum accreditation (5 years) from the Accreditation Council for Graduate Medical Education (ACGME) o The Internal Medicine Residencies at Waiter Reed Army Medical Center and the National Naval Medical Center are the only two programs still to integrate, but they may be the most challenging due to specific ACGME mandates o Deployments continue to affect the availability of faculty and program directors • Ms. Kenney reported that accreditation criteria regarding continuing education activities have greatly changed in the past year. USU's department of Continuing Education for Health Professionals is currently preparing for re-accreditation and its self-study is due to the Accreditation Council for Continuing Medical Education in December 2010 • Dr. Potter's brief on the U.S. Military Cancer Institute provided both background and current information o The institute's Clinical Trials Program, BioSpecimen Network, and Epidemiology Program are each unique in their ability to review and track large amounts of available data over time concerning treatment and outcomes within the Military Health System o A Comprehensive Cancer Center is being established in conjunction with the Walter Reed National Military Medical Center. The Academics Committee strongly supports the plan to incorporate significant aspects of the institute into the new center
5 • The Postgraduate Dental College supports Service dental residencies. Currently the Naval Postgraduate Dental School consists of eight programs and the Air Force Postgraduate Dental School has one. The college has moved forward quickly and additional growth is expected
Finance and Administration Committee Dr. Brawley reviewed the committee reports heard from the Office of Finance and Administration: • The university's Operations and Maintenance Budget for FY 2010 was $195.7 million, which included about $35 million in restoration projects at both USU and AFRRI. Also, 14 laboratories were funded for renovation • Current FY 2011 planning and funding challenges stem from the Department's initiatives to contain costs, the existing Continuing Resolution, and the university's recent implementation of a new accounting system
Dr. Brawley also summarized the report from Dr. Smith, Senior Vice President: • The recently established Office of Accreditation and Organizational Assessment will oversee USU's eighteen accreditations as well as carry out internal control functions at both the Department and university level • IT security remains a challenge. In the past six months, three major contracts have been awarded to replace outdated equipment, manage USU's video teleconferencing needs, and provide support services. Compared to similar institutions, the university has historically underfunded information technology
PRESENTATION: PATIENT CENTERED MEDICAL HOME The Patient Centered Medical Home is an established model of primary care which is patient-centered and access-focused. Dr. Kugler's presentation provided an overview of this initiative, which is currently being implemented across the Military Health System. • The concept consists of several principles o Each patient has an ongoing relationship with a personal physician o The personal physician leads a team of individuals who collectively are responsible for patients' ongoing care o The personal physician provides all the patient's health care needs or arranges other care as needed o Care is coordinated across all elements of the complex health care system o Quality and safety are hallmarks of the medical home o Enhanced access to care is available through such systems as open scheduling and expanded hours as well as communication between patients • Enrollment targets have been set for each Service and demonstration programs are ongoing at seven Military Treatment Facilities where success is being measured by collecting information on satisfaction, access, continuity, communication and healthcare quality • Within primary care, the medical home concept hopes to reduce visits per person, increase enrollment, and increase preventive services • Outside of primary care, the medical home concept hopes to reduce emergency room demand, reduce inpatient demand, and reduce specialty demand
6 • When fully implemented, the Patient Centered Medical Home policy should o Maximize readiness o Improve health outcomes and patient experiences o Enable sustainable costs
ADJOURNMENT Dr. Blanck adjourned the open portion of the meeting at 11 :30 a.m.
SUBMITTED: APPROVED:
William . ester Ronald R. Blanck Executive Secretary, Board of Regents Chair, Board of Regents
Prepared by Janet S. Taylor
7 Tab 8 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mll
'RD OF REGENTS November 10,2010
MEMORANDUM FOR CHAIR, USU BOARD OF REGENTS
SUBJECT: Record of Board Actions
According to the Board of Regents Bylaws, action may be taken by polling members individually or collectively by telephone, fax or e-mail. Any such action is then reported to the Board by the Executive Secretary at an open meeting and recorded appropriately in the minutes of record.
The following awards were electronically approved in October 2010 by a majority of Members:
• Distinguished Service Award to BG (Ret) William T. Bester
• Exceptional Service Award to John F. Potter, M.D.
William T. Bester, Brigadier General (Ret) Executive Secretary
Learning to Care for Those in Harm's Uizy UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mil
)ARD OF REGENTS January 7, 2011
MEMORANDUM FOR CHAIR, USU BOARD OF REGENTS
SUBJECT: Record of Board Actions
According to the Board of Regents Bylaws, action may be taken by polling members individually or collectively by telephone, fax or e-mail. Any such action is then reported to the Board by the Executive Secretary at an open meeting and recorded appropriately in the minutes of record.
The following actions were electronically approved in January 2011 by a majority of Members:
• The appointment ofV. Ann Stewart, D.V.M., Ph.D., to the rank of Associate Professor (with Tenure) as recommended by the School of Medicine Committee of Appointments, Promotion and Tenure at a meeting on December 21,2010.
• The Distinguished Service Award to Dr. Colleen Conway-Welch ~~~- William T. Bester, Brigadier General (Ret) Executive Secretary
Learning to Care for Those in Harm} U1ly Tab 9 Recommended Graduate Degrees - School of Medicine February 2011
Tab 10 James Mancuso Doctor of Public Health Department of Preventive Medicine and Biometrics
Tab 11 Jessica Forde Master of Science Medical and Clinical Psychology Graduate Program Tab 10 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
January 10,2011
MEMORANDUM FOR BOARD OF REGENTS Through: Charles L. Rice, M.D., President e{r.,.l h .... SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the degree of Doctor of Public Health effective upon your approval:
JAMES D. MANCUSO
DOCTOR OF PUBLIC HEALTH
Department of Preventive Medicine and Biometrics
Attached is the candidate's certification of successful completion of the Final Examination, approval sheet for the dissertation, certification of authorized use of copyrighted materials, thesis abstract and title page, and CV. ~~D. Dean, School of Medicine
Attachments: As stated
Eleanor S. Metcalf, Ph.D., Associate Dean II www.usuhs.mil/[email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 / 9474 II DSN: 295-9474 II Fax: 301-295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DOCTORAL DISSERTATION IN THE PREVENTIVE MEDICINE AND BIOMETRICS GRADUATE PROGRAM
Title of Dissertation: "An Evaluation of the Latent Tuberculosis Control Program in the United States Military at Accession"
Name of Candidate: James D. Mancuso Doctor of Philosophy Degree 10115/2010
[mOhr;; ABSTRACT APPROVED: DATE: f~6crl{)
Dr. David T .....·uu.\:; ..... DEPAR ENT OF REVENTIVE MEDICINE AND BIOMETRICS
rs «)q-- (0
T OF PREVENTIVE MEDICINE AND BIOMETRICS Dissertation Advisor N ~/Yr'v -'CLu--",~-- I~OC1ID Dr. Naomi Aronson DEPARTMENT OF MEDICINE Committee Member
Dr. Cara Olsen DEPARTMENT OF PREVENTIVE MEDICINE AND BIOMETRICS Committee Member. . ~ (_Q=!+\0J\rlV~ :~\7 Dr. Katherine Anderson I[ DEPARTMENT OF PREVENTIVE MEDICINE AND BIOMETRICS 7mitteeMe:p-_
I) cC.r z..O( u
~OTSUKAl>HARMACEUTICALS Committee Member
Eleanor S. Metcalf, Ph.D., Associate Dean II www.usuhs.mil/[email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 /9474 II DSN: 295-9474 II Fax: 301-295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS LIJG Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814 "1U
FINAL EXAMINATION/PRIV A TE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE PREVENTIVE MEDICINE AND BIOMETRICS GRADUATE PROGRAM
Name of Student: James D. Mancuso
Date of Examination: 10115/2010
Time: I :00 PM
Place: A2015
DECISION OF EXAMINATION COMMITTEE MEMBERS:
PASS FAIL
Dr. David Tribble DEPAR]:MEWT OF PREVENTIVE MEDICINE AND BIOMETRICS Co mfttee Char son
'k-:"' /) Iv tihyYl1 c-.~ Dr. Naomi Aronson DEPARTMENT OF MEDICINE Committee Member
Dr. Cara Olsen DEPARTMENT OF PREVENTIVE MEDICINE AND BIOMETRICS Committee Member ~d} ," Dr. Katherine Anderson DEPARTMENT OF PREVENTIVE MEDICINE AND BIOMETRICS ~mittee Member y~ ~------~iter OTSUKA PHARMACEUTICALS Committee Member
Eleanor S. Metcalf, Ph.D., Associate Dean II www.usuhs.mil/[email protected] Toll Free: 800-772-1747 " Commercial: 301-295-3913 1 9474 " DSN: 295-9474 " Fax: 301-295-6772 COPYRIGHT STATEMENT The author hereby certifies that the use of any copyrighted material in the thesis entitled: "An Evaluation of the Latent Tuberculosis Control Program in the United States Military at Accession" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
James D. Mancuso
Preventive Medicine and Biometrics
Uniformed Services University
12 September 20 I 0 Abstract
Title of Dissertation: An Evaluation of the Latent Tuberculosis Control Program
in the United States Military at Accession
Name, degree, year: James D. Mancuso, MD, MPH, Doctor of Public Health,
2010
Thesis directed by: Lisa W. Keep, MD, MPH, Assistant Professor, Preventive
Medicine and Biometrics, Uniformed Services University
of the Health Sciences
Although the Centers for Disease Control and Prevention (CDC) recommend targeted
testing for latent tuberculosis infection (L TBI), the military has continued universal
testing for all recruits. Furthermore, it has been suggested that the interferon-gamma
release assays (IGRAs) may be more specific and cost-effective than the tuberculin skin
-.---test+l'S'I}.--This.dissectation-examines.the..impacLo£propos.e.d..change.sirLs_cre.ening____ .____ . __ ._
policy at accession, including both targeted testing and the use ofIGRAs for screening.
The epidemiology of tuberculosis TB in the US military is similar to the general
population with an incidence that is low and declining. Risk factors for developing active
TB are similar to the general US population. Therefore, effective screening and
treatment at time of accession is a critical element of the military's TB control program.
Targeted testing was evaluated in US Army recruits at Fort Jackson using a
questionnaire, the TST, both commercially-available IGRAs. Prediction models were
III developed which demonstrated that targeted testing based on presence of four risk factors could eliminate 91 % of testing with a sensitivity of 79% and specificity of 92%.
TST positive, IGRA negative discordance was strongly associated with increasing BST size, suggesting that cross-reactivity to NTM may be an importance source of this discordance and false positive TSTs. Nevertheless, the tests largely identified different people as positive, suggesting that the majority of positives in heterogeneous, low prevalence populations are false positives using any of the three commercially-available
LTBI diagnostic tests.
Finally, the cost-effectiveness analysis found that targeted testing provided a better value than universal testing, a finding which was robust in sensitivity analysis. The IGRAs had a similar value to the TST but were slightly more costly, although the incremental cost effectiveness ratios were very sensitive to small changes in model assumptions.
As the US military is a heterogeneous, low-prevalence population, the use of targeted testing is recommended at accession in to military service. The TST and IGRAs were found to have similar performance characteristics and cost. Since the overall specificity of the TST and IGRAs are similar, targeted testing should also be performed when using the IGRAs, as with the TST.
IV An Evaluation of the Latent Tuberculosis Control Program in the United States
Military at Accession
by
James Dominic Mancuso
Doctoral Dissertation submitted to the Faculty of the Department of Preventive Medicine and Biometrics Graduate Program
of the Uniformed Services University of the Health Sciences
in partial fulfillment of the requirements for the degree of
Doctor of Public Health, 20 10
v Tab 11 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
January 10,2011
MEMORANDUM FOR BOARD OF REGENTS Through: Charles L. Rice, M.D., President ~L R . SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the Master of Science effective upon your approval:
JESSICA FORDE
MASTER OF SCIENCE
Medical and Clinical Psychology Graduate Program
Attached is the candidate's Dissertation Approval F onn, certification of authorized use of copyrighted materials, Thesis Abstract, Thesis Title Page, and Curriculum Vitae.
~~~~Ph.D.Dean,school~~
Attachments: As stated
Eleanor S. Metcalf, Ph.D., Associate Dean II www.usuhs.mil/[email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 / 9474 II DSN: 295-9474 II Fax: 301-295-6772 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 30,2010 DUATE PROGRAMS IN IOMEDlCAL SCIENCES rD PUBLIC HEALTH APPROV AL SHEET Ph.D. Degrees Title of Thesis: Effects of social desirability bias on self-report and :iplinary non self-report assessments during smoking cessation ng Infectious Diseases lar & Cell Biology :ience Name of Candidate: Jessica Forde lental I Psychology Department of Medical and Clinical Psychc.logy Imental Health Sciences Master of Science I Psychology 30 September 2010 I Zoology n Scientist (MD/Ph.D.) Thesis and Abstract Approved: )f Public Health (Dr.P.H.) raster oj Science Degrees
Health Masters Degrees And~rS' Ph.D. Department of Medical and Clinical Psychology r Medical History Health Thesis Advisor tl Medicine & Hygiene
, 'aduate Education Office q 3Dt 10 . Metcalf. Ph.D., Associate Dean Michael Feuerstein, la Arnett, Support Specialist Date ni Bull, Support Specialist Department of Medical and Clinical Psychology Committee Member
WebSite )://www.usuhs.mil/graded/ Ihs.millgeo/gradpgm index.html ~l I :Tc' Ir () E-mail Address J .. .? . I lduateprogram(al,usuhs.mil Neil E. Grunberg, P~. "''', . Date Departmen(ofMed~~icaIPsychology Phone Numbers )mmercial: 301-295-9474 Committee Member foil Free: 800-772-1747 DSN: 295-9474 FAX: 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
"Effects of social desirability bias on self-report and non self-report assessments during smoking cessation" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
Jessica Forde Medical and Clinical Psychology Graduate Program Uniformed Services University Social Desirability Bias in Smoking Cessation
TITLE: Effects of social desirability bias on self-report and non self-report
assessments during smoking cessation
BY: Jessica Forde, B.S.
2010
DIRECTED BY: Andrew J. Waters, Ph.D.
Associate Professor, Medical and Clinical Psychology
ABSTRACT
Social desirability response bias (SDR) is the tendency of respondents to respond in a way that will be viewed favorably by others. Little research has examined the effect of SDR in the context of cigarette smoking cessation. Adult smokers were recruited for smoking cessation treatment. They completed self-report, biological, and implicit attitude measures. SDR scores, assessed using the Balanced Inventory of Desirable Responding (Paulus, 1991), were dichotomized by median split into
LOW (0-12) and HIGH (13+). Compared to LOW partiCipants, HIGH participants reported lower levels of cigarette craving and more negative attitudes toward smoking. The groups did not exhibit different implicit attitudes toward smoking.
Averaged over sessions, the correlation between self-reported and implicit attitudes toward smoking was significant in LOW participants only. In sum, SDR may affect responses on some self-report measures used in smoking cessation research, suggesting that researchers should rely more on biological or implicit methods of assessment. Tab 12 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mil CE OF THE DEAN January 13,2010
MEMORANDUM FOR BOARD OF REGENTS
SUBJECT: Faculty Appointments
The attached are recommendations made by the Committee of Appointments, Promotion and Tenure at a meeting on December 21,2010. I recommend that you approve these recommendations and forward them to the President of the University for further processing. ~~in"""',-~.,Ph.D. Dean, School of MedIcine
Attachments
Learning to Care for Those in Harm So Way 1
PROPOSED FACULTY RECOMMENDATIONS February 1,2011
BOARD OF REGENTS
ACTION/CURRENT DEPARTMENTINAME PROPOSED RANK DUTY STA nON
OBSTETRICS/GYNECOLOGY
CLEMONS, Jeffrey L. Associate Professor* Promotion COL, MC, USA MAMC
FARLEY, John Professor Promotion COL,MC, USA USUHS
LEATH, Charles A. Associate Professor* Promotion Maj, USAF, MC BAMC
PATHOLOGY
SCHEXNEIDER, Katherine 1. Associate Professor* Promotion LCDR, MC, USN NNMC
PREVENTIVE MEDICINEIBIOMETRICS
GREENBERG, Warren Adjunct Professor* Appointment Ph.D. Washington, DC
MACALINO, Grace E. Associate Professor Appointment Ph.D. USUHS
RUSIECKI, Jennifer Associate Professor Promotion Ph.D. (With Tenure) USUHS
* Indicates non-billeted 2
SEILLIER-MOISEIWITSCH, F. Professor Appointment Ph.D. USUHS
SNELLING, Anastasia M. Adjunct Associate Professor* Appointment Ph.D. Washington, DC
STRICKMAN, Daniel A. Adjunct Associate Professor* Appointment Ph.D. Beltsville, MD
* Indicates non-billeted Tab 13 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES GRADUATE SCHOOL OF NURSING 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 www.usuhs.mll
MEMORANDUM FOR BOARD OF REGENTS
SUBJECT: Faculty Appointment
The attached are recommendations made by the Committee for Appointments, Promotion and Tenure at their December 15,2010 meeting. I recommend that you approve and forward it to the President of the University for further processing.
• Penny F. Pierce, Full Professor, Tenure Ineligible Track • Rosemary C. Polomano, Adjunct Associate Professor, Tenure Ineligible Track
LZ4~~ Ada Sue Hinshaw, PhD, RN, FAAN. Dean, Graduate School of Nursing
Attachments GRADUATE SCHOOL OF NURSING FACULTY RECOMMENDATIONS January 2011
BOARD OF REGENTS
DEPARTMENT/NAME PROPOSED RANK ACTION/CURRENT DUTY STATION
HEALTH, INJURY, AND DISEASE MANAGEMENT
PIERCE, Penny F. Professor* Appointment Ph.D. . (Non-Tenure) Ann Arbor, MI
NURSING SCIENCE PROGRAM
POLOMANO, Rosemary C. Adjunct Associate Professor* Appointment Ph.D. (Non-Tenure) Philadelphia, P A Tab 14 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES SOUTHERN REGIONAL OFFICE 7800 IH-10 West, Suite 220 San Antonio, TX 78230 http://www.u8uh8.mll
January 14,2011
MEMORANDUM FOR BOARD OF REGENTS
SUBJECT: Faculty Appointments
The attached are recommendations made by the Naval Postgraduate Dental School's Committee on Appointments and Promotion at a meeting on October 8, 2010. The Dean of the Naval Postgraduate Dental School provided his concurrence on January 13,2011. I recommend that you approve these recommendations and forward them to the President of the University for further processing. P~~DS'MA Interim Executive Dean and Professor Postgraduate Dental College
Attachments
Learning to Care for Those in Harm~ Way .. NAVAL POSTGRADUATE DENTAL SCHOOL FACULTY RECOMMENDATIONS January 2011
BOARD OF REGENTS
DEPARTMENT/ NAME PROPOSED RANK ACTION/CURRENT DUTY STATION
RESEARCH & CLINICAL INVESTIGATION
DIEFENDERFER, Kim E. Professor* Appointment CAPT, DC, USN (Non-Tenure) NNMC
COMPREHENSIVE DENTISTRY
MIKSCH, Vlasta Associate Professor* Appointment CAPT, DC, USN (Non-Tenure) NNMC Tab 15 Uniformed Services University of the Health Sciences Board of Regents
Board Brief
Submitted by: Dr. Ada Sue Hinshaw Date: February 1, 2011
Title & Department: Dean & Professor, GSN Phone 301-295-9004
Purpose: Information Action X ---- -'----
Subject: Transition of the Master of Science in Nursing (MSN) Degree to the Doctor of Nursing Practice (DNP) Degree
Significant Issues: The GSN recognizes the future impact of the American Association of Colleges of Nursing (AACN) decision to implement the Doctor of Nursing Practice (DNP) degree for advanced nursing practice from the master's degree to the doctorate level by the year 2015. GSN faculty endorsed a plan to integrate the DNP into the GSN's educational programs. Faculty members are developing plans to transform masters' curriculums to meet national DNP standards. The Federal Nursing Service Chiefs have been briefed on the DNP and support a phased master's program transition to the DNP that take; Service operational requirements into account. They would like this transition to begin with the Nurs Anesthesia, Family Nurse Practitioner, and Psychiatric Mental Health Nurse Practitioner options. Al three Military Service Chiefs have appointed members to a transition team to plan for implementing ;: GSN DNP Program by 2012 or 2013. On December 1,2010, the Congressional Record endorsed the DNP as required academic preparation for advanced nursing practice and asked for a GSN report in 180 days outlining progress toward "DNP program transition and planned implementation."
Current & Future Concerns: Faculty members in these three advanced practice nursing program options will experience significan demands and increases in workload as the curriculum is converted and educational time lines extendee For a transition period both the master's program options and the DNP will be offered in parallel. A third cohort of students in the DNP Program will increase the number of GSN students. Resources will be required to teach the added curriculum, fund student travel, and purchase textbooks and supplies. Student scholarly projects will also affect faculty workload. The DNP student will be required to complete a capstone project requiring more faculty intensive supervision across the stude) cohort.
Funding/Budget Estimate/Fiscal Impact: Every effort is being made to maximize collaborative opportunities with the USU School of Medicine where appropriate, to assist in teaching new DNP curriculum. GSN resources to support the conversion of the Master's Programs to the DNP will include an increase of six faculty (4 civilian ane 2 military), one administrative support specialist, funds for associated travel, textbooks, and supplies February 20 support an additional cohort of GSN students, and space for offices and classrooms. These requirements will be addressed during future budget cycles.
Board Action Requested: Approve a motion to transition the GSN graduate degree program for the Nurse Anesthesia, Family Nurse Practitioner, Psychiatric Mental Health Nurse Practitioner options from the Master of Science i Nursing (MSN) degree to the Doctor of Nursing Practice (DNP) degree.
February 20] Tab 16 Carol J. Johns, M.D. Medal
Doctor Carol J. Johns was a long-time enthusiastic and effective supporter of the Uniformed Services University of the Health Sciences. Doctor Johns worked for the health and survival of the University in numerous ways. She served as a member of the USU Board of Regents from 1985 until her death in 2000. A warm and gifted woman with remarkable personal humility and gentleness, Doctor Johns achieved the highest honors in academic medicine as a nationally recognized clinician, academician, and teacher. The University has established an annual award in her name, the Carol J. Johns, M.D. Medal. The medal will honor the faculty member whose accomplishments emulate Doctor Johns' spirit in: furthering the welfare and excellence of the USU faculty; promoting outstanding educational programs for the students and advancing the reputation of the University locally, nationally, and internationally. The Carol J. Johns, M.D. Medal, was presented for the first time at the 2001 Commencement. UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 www.usuhs.mll
22 October 2010
MEMORANDUM FOR ANTHONY R. ARTINO, JR., PHD, FASMA, CASP, LCDR, MSC, USN, SECRETARY-TREASURER, USU FACULTY SENATE
RE: Nomination of Sheila Muldoon, MD, for the 2011 Carol J. Johns Medal
We write to nominate Sheila Muldoon, MD, Professor and former Chair of Anesthesiology, for the 2011 Carol J. Johns Medal. Dr. Muldoon's career at USUHS has spanned nearly the entire life of the University. She arrived as a young assistant professor in 1977, as Building A was being completed. As Chair of Anesthesiology between 1984 and 2001, she was instrumental in first building and then enhancing Anesthesiology course offerings and residency programs, USU clinical faculty, and the University's support of and relations with the Department of Defense as well as each of the military services that send faculty and students to the University. She has also established not just a research career of international stature but also an essential, USUHS-based testing service for military patients and their families believed susceptible to malignant hyperthermia (MH), a relatively rare disease with rapid onset and often fatal outcome arising in response to common anesthetic agents. Some of her most important accomplishments are described below. The letters of support for her nomination - many of which are mentioned here - have come from only a selection of Dr. Muldoon's highly successful colleagues and proteges within USUHS and across the United States.
Once tenured and appointed as Vice Chair of Anesthesiology in 1980, Dr. Muldoon was charged with working out the details of clinical teaching and research infrastructure in the early years of the University and the Department of Anesthesiology. Letters from a few of her contemporaries at USUHS - Brian Cox, Harvey Pollard and I1dy Katona - provide details of some of her major accomplishments in establishing instructional strategies and resources both within Anesthesiology and across departments, whether in teaching about anesthetics during the Medical Pharmacology course; establishing mutually supportive relationships with clinical as well as with basic-science chairs; or cobbling together one of the fIrst patient-simulation centers in the nation. She was also instrumental in the design and estabHshment of several physiology courses, including a USU-unique smooth-muscle lab that evolved into the so-called "pig lab."
As Chair of Anesthesiology, Dr. Muldoon recruited, hired and mentored then-MAl Michael Mahla and then-LCDR Jerry Burger, the first junior military anesthesia faculty. By obtaining and defending not just offices but also laboratories adequate to their research needs, she not only provided far-seeing mentorship for faculty but also nurtured some of the first translational research at the University. Drs. Muldoon. Mahla and Berger also developed the USU anesthesia clerkship curriculum. Unlike the standard model for US programs, it provided instruction in skills essential for physicians of all specialties. Letters from Drs. Mahla and Paul Pudimat describe Dr. Muldoon's contributions to that course and its evolution.
Learning 10 Care/hI" Those in Harm :,' Way Dr. Muldoon also devoted major effort to cultivating USU's relations with military residency programs, ensuring that USU anesthesia graduates were well received by military clinicians and hospitals across the us. In the early 19805, the US military's move toward jointness had just begun -- and was indeed deeply resisted by many military clinicians who also believed that the new University was simply redundant. As several letters indicate, the initial reluctance to accept USU graduates was overcome largely by Dr. Muldoon's acumen as both clinician and basic scientist, the sense of reciprocity in her relations with the residency programs, her personal warmth and wit, and her obvious devotion to USU students and the quality of their education. In the mid-1990s, Dr. Muldoon helped to establish the structure and staffing of the National Capital Consortium anesthesia residency program. At a time when the ACGME consistently expressed concerns about military residencies due to a perceived danger of shallow scientific teaching and a lack academic support, Dr. Muldoon's leadership and mentoring --exemplified by her ability to build coalitions by eliciting the trust, respect and often friendship of other program directors (both civilian and military) - were instrumental and essential in establishing the NCC anesthesia residency program. Today it is one of the most respected in the country.
The key to the success of the Anesthesia clerkship and residency programs lay in wise recruitment and development of Anesthesiology's military faculty. There would be no academic anesthesiology in the military without Dr. Muldoon. She was notably successful obtaining gifted teachers, clinicians and researchers from all three services, not least because she could see that her faculty - billeted and non billeted - were promoted both academically and within their services. Then-CDR Paul Pudimat was among the first USU military faculty member to reach the rank of associate professor. Ildy Katona describes Dr. Muldoon's essential contributions to the development of USUHS Instruction 1100, formalizing criteria for promotion that acknowledged the needs and contributions of military faculty, particularly those that are hospital-based. In that effort, Dr. Muldoon's concerns revolved around appropriate recognition and reciprocity in the relationships between USU and its faculty, the hospitals, and the service chiefs. COL Paul Mongan, who also won academic promotion under Dr. Muldoon's watch, became the only military member of the highly selective Association of University Anesthesiolo gists - again thanks to Dr. Muldoon's mentorship. Then-LTC Cynthia Shields, then-LTC Chester (''Trip'') Buckenmaier and then-CDR Darin Via were all promoted from Assistant to Associate Professor during Dr. Muldoon's time as Chair; Paul Mongan was promoted from Associate to Full Professor. COL Geoffrey Ling rose to Full Professor of Anesthesiology as a secondary appointment. At least two faculty rose in military rank under Dr. Muldoon's supervision: Stephen Holman (CDR to CAPT) and Rom Stevens (CDR to CAPT).
Most recently, Dr. Muldoon has taught for the Nurse Anesthetist program in the Graduate School of Nursing and mentored nursing PhD students with an interest in genetics. Roopa Biswas and Christine Kaspar outline those contributions from the GSN faculty's standpoint, whereas Maureen Hood and Lt. Col. Susan Perry do so from a GSN student's perspective. Dr. Muldoon's lectures in the GSN Nurse Anesthetist program have been effective and well-received and, as Prof. Hood and Lt. Col. Perry attest, the GSN doctoral students under her direction receive not only rigorous scientific training, support and scrutiny but also instruction and Sllpport in obtaining funding from outside agencies.
Dr. Muldoon's recognition of the interlocking values of basic science and clinical medicine reaches back to her post-doctoral work in physiology at the Mayo Clinic in Rochester, MN, in the mid-1970s. Gerald Gronert, one of her early instructors and then a long-time colleague, describes her impressive early work
2 in vascular physiology as well as the originality and significance of her later MIl investigations. She brought an NIH grant from Mayo on the anesthetic effects of vascular neure-effector systems (1976- 1984) and later won a series of grants from Baxter Blood Products (via the Henry M. Jackson Founda tion) to study the pressor effects of diasprin cross-linked hemoglobin on isolated blood vessels (1994- 1999).
From that work, Dr. Muldoon moved into investigating the basic mechanisms ofMH. As several ofthe supporting letters attest, Dr. Muldoon has been essential in establishing diagnostic standards, a national registry ofMH-susceptible military patients and their families, and best practices for clinical management of malignant hyperthermia. Her interest in MH began in the late 1970s, when COL Robert Watson, then chair of Anesthesia, received a series of requests for guidance from small Army hospitals that had encountered cases ofMH, which then lacked effective treatment and was extremely difficult to manage. COL Watson sent Dr. Muldoon to Children's Hospital to learn what was known about the disease and develop materials to distribute to Army hospitals, hoping to introduce it to OR staffs in the other services as well. Letters from several of Dr. Muldoon's colleagues in MH research describe her subsequent involvement in developing reliable diagnostic tests as well as standardizing effective management tech niques. In the early 19805, dantrolene was established as an effective means of halting an :MIl episode if delivered immediately. COL Watson promptly drew on Dr. Muldoon's work to convince Army Surgeon General Bernard T. Mittemayer to mandate stocking dantrolene in all Army DRs. The other SGs soon followed -- all several years before civilian hospitals began the same practice and JCHAO made readily available dantrolene mandatory for all US hospitals.
As Dr. Muldoon's expertise and reputation grew, her lab began to provide testing and counseling for military patients suspected of being susceptible to MH and guidance for military surgical teams who identified them, including urgent calls from those handling MH crises in military DRs across the country. A formal 000 database and referral service was started in 1988, when Dr. Muldoon became consultant to the Assistant Secretary of Defense for Health Affairs. As both Paul Allen (Harvard University) and Susan Hamilton (Baylor College of Medicine) point out, Dr. Muldoon now heads one of the precious few remaining testing centers in the country. Her recognized authority on MH was the key data point in dispositioning multiple service personnel undergoing physical-examination review boards after episodes suspicious for MH. Diagnostic testing by Dr. Muldoon's lab can determine the length a military career: a positive result for MH ends that career, although a false negative risks ending the service member's life. Accurate diagnoses for service members became even more important due to the findings of researchers such as Patty Deuster (MEM), who began her USU career as Dr. Muldoon's post-doctoral fellow: those susceptible to heat stroke are now known to be at risk for heat- or exertion-induced MH episodes as well.
The civilian Malignant Hyperthermia Association of the United States (MHAUS) was founded in 1982. Dr. Muldoon was among its first members. MHAUS maintains a hotline, staffed by volunteer physician experts, for healthcare providers, patients and their families. Dr. Muldoon volunteered from its inception and took calls for over 20 years; even now, she often fields knotty questions from the clinicians currently covering the hotline. When the North American MH Registry joined MHAUS in 1995, she became chair of the Registry's oversight board. She joined the MHAUS Board of Directors in 1996 and became its Vice-President for Scientific Development in 200 I. Letters contributed by several of her MH colleagues attest to both her eminence and her dedication in helping patients, providers and family members as well as the advancement of scientific understanding ofMH.
3 Dr. Muldoon's initial research in MH centered on establishing appropriate controls, sensitivity and speci ficity for MH diagnostic testing, first in the definitive caffeine halothane contracture test (CHCT) and more recently in developing genetic testing. Because CHCT requires biopsy of a major muscle, Dr. Muldoon has also been prominent in widespread efforts to devise a less invasive test. When a candidate gene for MH was identified in 1990, she learned the techniques to begin work on genetic studies despite a belief among many of her US colleagues that MH was simply a collection of symptoms with no heredi tary basis. Starting in the mid-1990s, following a European model, Dr. Muldoon began a series of studies ofMH families in the US to identify patterns in both clinical presentation and genetics, and to develop less-invasive tests involving T-cells and B-cells. Drs. Yoshitatsu Sei and Leslie McKinney, who worked on the latter under Dr. Muldoon's guidance, describe her mentorship during those investigations .
. Dr. Muldoon stepped down as Anesthesiology chair in 2001. Her immediate successors, COL Paul Mongan (2001-2006) and CAPT Cynthia Shields (2006-2010), describe her mentorship as well as her accomplishments, international renown, and value to US military medicine.
Most recently, Dr. Muldoon has become a co-investigator on two major MH grants. She provides the human studies for a genetics-based NIH Project Program Grant with Paul Allen (Harvard) and, more recently, both pig and human data for a DMRP grant with Susan Hamilton (Baylor). Dr. Allen and Dr. Hamilton describe the value of Dr. Muldoon's contributions to those projects as well as her eminence in her profession, both nationally and internationally. In 2006, Dr. Muldoon was instrumental in hiring Nyamkhishig Sambuughin, a PhD geneticist from the Laboratory of Clinical Genetics at the National Institute of Neurological Disorders and Stroke. She has also mentored an associate director for the MH testing center, Dr. John Capacchione. Drs. Sambuughin and Capacchione describe their experience in working with Dr. Muldoon in separate letters.
All ofthese accomplishments notwithstanding, Dr. Muldoon remains astonishingly humble. Even in providing the historical background for this letter, she repeatedly and unself-consciously explained, "It wasn't really me, it was [the program, the student, the science, the collaborator, the protege] that made the difference." Her other mantra, however, is "If you don't get involved, you don't have anything to bring to the table." Her dedication to getting involved - to scientific rigor and investigation, to patient care, to the education ofa full range ofUSU students and junior faculty, to building trust and particularly to cementing strong relationships among clinical chairs and across the basic sciences -- is exemplary. Her devotion to the University and its service to the US military is rivaled only by her devotion to individual patients, families, students and faculty she encounters.
On these grounds, we and the twenty-eight others who have written in support of Dr. Muldoon's nomina tion strongly recommend her for the Carol J. Johns Medal. I~WL-.I_/ _ l CltLcd?P7Cl Kristin Heitman, Ph.D. Dale Szpisjak, CAPT, MC, USN Assistant Professor Associate Professor and Interim Chair Departments of Medical History and Department of Anesthesiology Preventive Medicine and Biometrics
4 CURRICULUM VITAE (abbreviated)
VIE: Sheila M. Muldoon, M.D.
JCATIONAL BACKGROUND:
1957 - Jun 1958 University College Dublin, Ireland
1958 - Jul1963 M.B., B.Ch., B.A.O. University College Dublin, Ireland
1963 - Jul1964 Intern Mater Hospital, Dublin, Ireland
1965 - J uI 1966 Residency in Anesthesia Mater Hospital, Dublin, Ireland
1966 - Oct 1969 M.S. in Anesthesiology & Physiology Mayo Graduate School of Medicine, University of Minnesota, Rochester, MN
DICAL LICENSURE: Maryland
POINTMENTS: r 2001 - Present: Professor of Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD
)t 1987 - 2001 Chairperson - Professor Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD
11988 - 1992 Consultant to the Assistant Secretary of Defense for Health Affairs Office of the Assistant Secretary of Defense Health Affairs, Washingtor
)t 1984 - 1987 Acting Chairperson - Professor of Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD
)t 1980-1984 Vice Chairperson - Associate Professor of Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD 1978 - Oct 1984 Associate Professor of Physiology and Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD
1977 - Oct 1978 Assistant Professor of Physiology and Anesthesiology Uniformed Services University of the Health Sciences, Bethesda, MD
1975 - Sep 1977 Assistant Professor of Anesthesiology Mayo Medical School, University of Minnesota, Rochester, MN
1973 - Jun 1975 Instructor in Anesthesiology Mayo Medical School University of Minnesota, Rochester, MN
: 1969 - Jan 1973 Consultant in Anesthesiology Mayo Clinic, Rochester, MN
"ORS AND MAJOR RESEARCH FUNDING:
ng Investigator Award, American Society of Anesthesiologists, 1973-74
~rican Heart Association Grant-in-Aid, 1973-76
onal Institutes of Health, "General Anesthetic Effects of Vascular Neuro-effector Systems," 19' 4
(son Foundation Research Award (Baxter Blood Products), "Pressor Effects of Diasprin Cross :ed Hemoglobin on Isolated Blood Vessels," 1994-1999
onallnstitutes of Health, "The Molecular Basis of RyR1 Myopathies," Program Project Grant \A Paul Allen (PI), 2006-2011 ignant Hyperthermia Association of the United States (MHAUS) Special Recognition Award, 2(
:mse Medical Research Program (DRMP), "Novel Interventions for Heat/Exercise-induced Sud lth and Fatigue," with Dr, Susan Hamilton (PI), 2010-2013
)FESSIONAL MEMBERSHIPS:
~rican Physiological Society
~rican SOCiety of Anesthesiologists ociation of University Anesthetists
, and Maryland Society of Anesthesiologists
2 "national Anesthesia Research Society ignant Hyperthermia Association of the United States Founding member, Board of Directors, 1982- present Advisory Council Chair, North American Hyperthermia Registry, 1996-present Vice-President for Scientific Development, 2002- present
11a Xi
MMITTEE ASSIGNMENTS AND ADMINISTRATIVE EXPERIENCE: llber, ad-hoc study section on , National Institutes of Health, Bethesda, MD, 1980-1981 llber, Surgery, Anesthesiology and Trauma Study Section, National Institutes of Health, Bethe: ,1983-87
Iminer, the American Board of Anesthesiology, 1984-85 mber, Scientific Advisory Board Association of University Anesthesiologists, 1989-92 liewer, Anesthesiology Research Committee (FAER), American Society of Anesthesiologists, 1 liewer, American Heart Association, 1992 liewer, Journal of Cardiovascular Pharmacology mber, ASA Committee on Uniformed Services and Veterans' Affairs, 1994-1996 mber, ASA Subcommittee on Drug Disposition and Aesthetic Action, 1994-1996 liewer, American Society of Anesthesiologists (ASA) Research Awards for residents, fellows al Ing investigators, 1994-1996 mber, Anesthetic and Life-Support Drugs Advisory Committee, Food and Drug Administration, )1-1995 mber, USUHS Continuing Education Committee air, USUHS Ad-Hoc Space Committee, 1996-1998 mber, USUHS Committee on Appointments, Promotion and Tenure, 2000-2003.
3 :JLlCATIONS:
Muldoon. S.M., and Theye, RA: The effects of succinylcholine and d-tubocurarine on oxyger. ~onsumption. Anesthesiology 31 :437-442, 1969.
~orie, D.K., Muldoon, S.M., and Krabill, D.R: Transient bundle branch block occurring during :mesthesia: Report of a case. Anesth Analg 51 :633-637, 1972.
Muldoon, S.M., Rehder, K., Didier, E.P., Divertie, M.B., Douglas,W.W., and Sessler, AD.: ~espiratory care of patients undergoing intra-thoracic operation. Surg Clin N Amer 53:843- 357,1973.
\t1uldoon, S.M., and Vanhoutte, P.M.: Venous relaxation by halothane acting on the sympathel lerves. Arch Int Pharmacodyn Ther 213:330-331,1975.
_andmark, S.J., Muldoon, S.M., Nolan, N.G., and Coventry, M.B.: Sequential blood volume ~hanges in patients undergoing total hip arthroplasty. Anesth Analg 54:391-397, 1975.
V1uldoon, S.M., Vanhoutte, P.M., Lorenz, RR, and Van Dyke, P.A: Venomotor changes caUS4 lalothane acting on the sympathetic nerves. Anesthesiology 43:41-48, 1975.
V1uldoon, S.M., Verbeuren, T.J., and Vanhoutte, P.M.: Effects of amide- linked local anestheti )n adrenergic neuroeffector junction in cutaneous veins of dogs. J Pharmacol Exp Ther 196:7 r36,1976.
V1uldoon, S.M., Janssens, W.J. and Vanhoutte, P.M.: Alpha-adrenergic blocking properties 0 jroperidol on isolated blood vessels of the dog. Br J Anaesth 49:211-216,1977.
V1uldoon, S.M., Vanhoutte, P.M., and Tyce, G.M.: Norepinephrine metabolism in canine saphE lein: Prevalence of glycol metabolites. Am J Physiol 234(3):235-243, 1978.
V1uldoon, S.M., Tyce, G.M., Moyer, T.P., and Rorie, D.K.: Release of Endogenous norepineph NE) from adrenergically innervated veins. Fourth International Catecholamine Symposium: :atecholamines: Basic Clinical Frontiers, Eds. Earl Usdin, Irwin J. Kopin and Jack Barchas. =>ergamon Press 2:1488-1490,1978. v1uldoon, S.M., Tyce, G.M., Moyer, T.P., and Rorie, D.K.: Measurement of endogenous lorepinephrine overflow from canine saphenous veins. Am J Physiol 236(2):H263-H267, 197~
~orie, D.K., and Muldoon, S.M.: Increased Reactivity of Isolated Rabbit Saphenous Vein after rreatment with Estrogen and Progesterone. Blood Vessels 16:252-258, 1979.
~orie, D.K., Tyce, G.M., and Muldoon, S.M.: Effects of fentanyl on adrenergic nerves in coroni irtery. Anesthesiology 51 (3S):S145, 1979.
4 Rorie, D.K., Muldoon. S.M., and Tyce, G.M.: The specific activity of retained and released 10repinephrine in dog saphenous vein prelabeled with radiolabeled norepinephrine. Life Sci ~6:707-714, 1980.
Rorie, D.K., Muldoon. S.M., and Tyce, G.M.: Disposition of norepine-phrine during nerve stimulation in dog saphenous vein. Am J Physiol 239:H23-H246, 1980.
Baskoff, J.D., Watson, RL., and Muldoon. S.M.: Respiratory arrest after intrathecal morphine Case Report). Anesthesiology Review VII (9): 12-15, 1980. . Hyatt, M., Muldoon. S.M., and Rorie, D.K.: Oroperidol, a selective antagonist of postsynaptic a adrenoceptors in the canine saphenous vein. Anesthesiology 53:281-286, 1980.
Rorie, D.K., Muldoon. S.M., and Tyce, G.M.: Effect of fentanyl on adrenergic function in canin coronary artery. Anesth Analg 60:21-27, 1981.
Steffen, RP.M., Pamnani, M.B., Clough, D.L., Huot, S.J., Muldoon. S.M., and Haddy, F.J.: Eft prolonged dietary administration of vanadate on blood pressure in the rat. Hypertension 3(31):1 1178,1981
Doblar, D.O., Muldoon. S.M., Abbrecht, P.H., Baskoff, J., and Watson, RL.: Epidural morphin~ following epidural local anesthesia: Effect on ventilatory and airway occlusion pressure respor C02. Anesthesiology 55(4):423-428, 1981. t:'reas, W., Muldoon. S.M., and Haddy, F.J.: Accumulation of 3H_ Norepinephrine in the dog saphenous vein: Influence of plasma. Am J Physiol 243(3):H424-H433, 1982.
Muldoon. S.M .. Rorie, D.K., and Tyce, G.M.: Effect of L-dopa on adrenergic transmission in isolated canine saphenous veins. Proc Soc Exp Bioi Medicine 170:341-349,1982.
Todd, RD., Muldoon. S.M., and Watson, R.L.: Determination of morphine in cerebrospinal flui and plasma by high-performance liquid chromatograph with electrochemical detection. J Chro Biomed Appls 232:101-110,1982.
Muldoon. S.M .. Otto, J., Freas, W., and Watson, RL.: Effect of Morphine, Nalbuphine, and Butorphanol on Adrenergic Function in Canine Saphenous Vein. Anesth Analg 62:21-8, 1983.
Freas, W., Carrillo, A., DiMarzio, L., Haddy, F.J., and Muldoon. S.M.: Partial isolation of an endogenous norepinephrine uptake inhibitor in canine plasma. Am J Physiol 245(14):H336-H: 1983.
Maiewski, S., Muldoon. S.M., and Mueller, G.P.: Anesthesia and stimulation of pituitary beta endorphin release in rats. Proc Soc Exp Bio Med 176:268-275, 1984.
Muldoon. S.M., Donlon, M., Todd, R.O., Helgeson, N., and Freas, W.:Comparison of Histamin~ release with Nalbuphine and Morphine in anesthetized dogs. Agents and Actions 15:229-234, 1984.
5 Eng, G., Becker, M., and Muldoon. S.M.: Electrodiagnostic tests in the detection of Malignant Hyperthermia. Muscle and Nerve 7:618-625, 1984.
Blanck, T.J.J., Fisher, Y.I., Thompson, M., and Muldoon. S.M.: Low molecular weight proteins human malignant hyperthermic muscle. Anesthesiology 61 (5):589-592, 1984.
Brady, L.S., Mansbach, R.S., Skurdal, D.N., Muldoon. S.M., and Barrett, J.E.: Reversal of the anti nociceptive effects of centrally-administered morphine by the benzodiazepine receptor antagonist. Life Sci 35:2593-2600, 1984.
Deuster, P.A., Bockman, E.L., and Muldoon. S.M.: In vitro responses of cat skeletal muscle to halothane and caffeine. J Appl PhysioI58:521-527, 1985.
McKenzie, J.E., Anselmo, D., and Muldoon. S.M.: Nalbuphine's Reversal of Hypovolemic Sho the Anesthetized Rat. Circ Shock 17:21-33, 1985.
Biscardi, H.M., Muldoon. S.M., and Condon, B.F.: Diagnosis of Malignant Hyperthermia. Mil ~ 150:293-296, 1985.
Fishbein, W.N., Muldoon. S.M .. Deuster, P.A., and Armbrustmacher, V.W.: Myoadenylate deaminase deficiency and malignant hyperthermia: Is there a relationship? Biochem Med 33: 169,1985.
Freas, W., Todd, R., Tyce, G., and Muldoon.S.M.: The effect of etidocaine on spontaneous ar evoked release of norepinephrine from rat brain synaptosomes, Proc of Soc for Exp Bio Med 180:264-269, 1985.
Deuster, P., Bockman, E., Biscardi, H., and Muldoon. S.M.: Verapamil and Zero Ca++ Alter Responses of Cat Muscle to Halothane and to Caffeine. J Appl Physiol 60:935-941, 1986.
Muldoon. S.M., Freas, W., Mahla, M., and Donlon, M.: Plasma histamine and catecholamine I during hypotension induced by morphine and compound 48/80. J Cardiovasc Pharmacol9:57 583,1987.
Nagarajan, N., Fishbein, W.N., Muldoon. S.M., and Pezeshkpour, G.: Calcium uptake in frozE muscle biopsy sections compared with other predictors of malignant hyperthermia susceptibili1 Anesthesiology 66:680-685, 1987.
Muldoon. S.M., Collins, F., and McKenzie, J.: Evidence of sympathetic medullary involvemen1 the pressor response to nalbuphine in hemorrhagic shock. Circ Shock 26:89-98, 1988.
Freas, W., Thompson, D., Hart, J., Haddy, F., and Muldoon. S.M.: Further isolation of endoger factors in canine and human plasma that inhibit 3H Norepinephrine Acculation. Neurochem In 12(3):297-305, 1988.
6 Muldoon. S.M., Hart, J.L., Bowen, K.A., and Freas, W.: Attenuation of Endothelium-mediated fasodilation by Halothane. Anesthesiology 68:31-37, 1988.
Hart, J.L., Freas, W., McKenzie, J.E., and Muldoon. S.M.: Adrenergic nerve function and contractile activity of the caudal artery of the streptozotocin diabetic rat. J of Auto Nerv Syst 2~ 57, 1988.
Freas, W., Hart, J.L., Golightly, D., McClure H., and Muldoon. S.M.: Contractile properties of isolated vascular smooth muscle following photoradiation. Am J Physiol 256:H655-H664, 198~
Robinson-White, A.J., Muldoon. S.M., and Robinson, F.C.: Inhibition of inositol phospholipid hydrolysis in endothelial cells by pentobarbital. Eur J of Pharmacol 172:291-303, 1989.
Muldoon. S.M., Cress, L., and Freas, W.: Presynaptic adrenergic effects of anesthetics. Interr Anesth Clin 27:259-264, 1989.
Robinson-White, A.J., Muldoon. S.M., Elson, L., and Collado-Escobar, D.M.: Evidence that barbiturates inhibit antigen-induced responses through interactions with a GTP-binding protein rat basophilic leukemia (RBL-273) cells. Anesthesiology 72:996-1004, 1990.
Freas W., Hart, J.W., Golightly, D., McClure, H., Rodgers, D.R, and Muldoon. S.M.: Vascular Interactions of calcium and reactive oxygen intermediates produced following photoradiation .. Cardiovasc PharmacoI17:27-35, 1991.
Cress, L.W., Freas W., Haddy, F., and Muldoon. S.M.: The effects of bufalin on norepinephrin l turnover in canine saphenous vein. Hypertension 18(4):516-522, 1991.
Muldoon. S.M.: Anesthetic Effects on Vascular Smooth Muscle. Mechanisms of Anesthetic Ac in Skeletal, Cardiac and Smooth Muscle 301:207-213,1991.
Freas, W., Llave, R, Hart, J.L., Kobayashi, Y., Nagel, J., and Muldoon. S.M.: Effect of reactivE oxygen intermediates produced by photoradiation on neurovascular function. Neuropharmaco 31(8):809-815, 1992.
Hart, J.L., Jing, M., Bina, S., Freas, W., Van Dyke, RA., and Muldoon. S.M.: Effect of halothal EDRF/cGMP-mediated vascular smooth muscle relaxations. Anesthesiology 79:323-331,199:
Muldoon. S.M., and Van Dyke, RA.: Nitric oxide and anesthetics. Curr Opin in Anesth 7:87-9 1994.
Karan, S.M., Crowl, F., and Muldoon. S.M.: Malignant Hyperthermia Masked by Capnographi< Monitoring. Anesth Analg 78:590-2, 1994.
Jing, M., Hart, J.L., Bina, S., and Muldoon. S.M.: Vascular effects of halothane and isoflurane: cGMP-dependent and independent responses of the rat aorta. Life Sci 56: 19-29, 1995.
7 Bina, S., Hart, J.L., and Muldoon. S.M.: Comparative effects of exogenous nitravasodilators or :GMP levels in different canine blood vessels. Life Sci 56:33-38, 1995.
=reas, W., L1ave, R., Jing, M., and Muldoon. S.M.: Contractile effects of diaspirin crosslinked lemoglobin (DCLHb™) on isolated porcine blood vessels. J Lab Clin Med, 125:762-767,1995
Jing, M., Ledvina, M.A, Hart J.L., Bina S., and Muldoon. S.M.: Effects of halothane and isoflurc )n diaspirin crosslinked hemoglobin TM_ induced contractions of porcine pulmonary veins. Art C Blood Subs Immob Biotech 23:487-494,1995. 3rissom, T., Bina, S., Hart, J.L., and Muldoon. S.M.: Halothane decreases phenylephrine-indu lascular smooth muscle contractions in endotoxin-exposed rat aortic rings. Crit Care Med 24(: 287-293, 1996. Jing M., Bina S., Verma A, Hart J.L., and Muldoon. S.M.: Effects of halothane and isoflurane 0 :arbon monoxide induced relaxation in the rat aorta. Anesthesiology 85:347-354, 1996. \t1uldoon S.M., Ledvina, M., Hart, J.L., and Macdonald, V.W.: Hemoglobin-induced contraction Jig pulmonary veins. J Lab Clin Med 128:579-584, 1996. Jing, M., Panico, F.G., Ledvina, M.A, Bina, S., and Muldoon. S.M.: Diaspirin cross-linked lemoglobin does not alter isolated human umbilical artery or vein tone. Art Cells Blood Subs mmob Biotech 24:621-628,1996. -iart, J.L., Ledvina, M.A, and Muldoon. S.M.: Actions of diaspirin cross-linked hemoglobin on solated rat and dog blood vessels. J Lab Clin Med 129:356, 1997. Jing, M., Ling, G.S.F., Bina, S., Hart, J.L., Muldoon. S.M.: Halothane attenuates nitric oxide ·elaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cycle =ur J PharmacoI342:217-224, 1998. 3ina, S., Hart, J.L., Sei, Y., and Muldoon. S.M.: Factors contributing to differences in the regule )f cGMP in isolated porcine pulmonary vessels. Eur J Pharmacol 351 (2) ; 253-260, 1998 (ogayashi, Y., Muldoon. S.M., Kiyose, M., Hagiwara, S., Kumasaka, S., and Okabe, E.: Inhibit )y midazolam of the adrenergic function in the isolated caninie. Acta Anaesthesiologica 3candinavica 42: 1157-1163, 1998. 8 Sei, Y., Gallagher, K., Flora, M., Ling, G., and Muldoon. SM: Methods to detects the RYRI nutations G742A and A 1565C using an amplification-modified restriction sites technique. Clin ~8:1 :74-78, 1998 Ledvina, M.A., Hart, J., Bina, S., Jing, M., and Muldoon.S.M .. Endothelin plays a role in diaspiri crosslinked hemoglobin (OCHLB)-induced contraction of isolated pig pulmonary vessel. J Lab ( Med 133:478-87, 1999 Muldoon SM, Verma A. Jing M. Bunger R; Nitric Oxide: Mechanism of Action, Pages 274-284 2000 Molecular Pharmacology of Anaesthesia. Edited by; J. Schulte am Esch, J. Scholz, P.H Tonner. Pabst Science Publishers 0-49525 Lengerich Sei Y, Gallagher KL, Bina S, Pudimat P, Muldoon SM: Expression of Type 1 Ryanodine Recep and increased Calcium Response to Caffeine and 4 Chloro-M-Cresol in B lymphocytes from Malignant Hyperthermia Patients, Anesthesiology 91 :A338, 1999 Mongan, PO, Bina,S, Fontana, JL, Bunger, R, Muldoon.SM: Pyruvate, But Not Lactate, Enhan( contraction of Isolated Porcine Carotid Arteries, Anesthesiology 91 :A650, 1999 Muldoon. S.M, K.Galiagher, S. Holman and M.G. Larach: North American Malignant Hyperthe Registry. Pages 377-0382, 2000. J.Schulte am Esch, J.Scholz, F.Wappler (Eds) Pabst Science Publishers 0-49525 Lengerich, N.Sambuughin, Y.Sei, T.Nelson, H.Rosenberg, Muldoon S.M., Screening of the Ryanodine Receptor Gene and Identification of Novel Mutations in North American Malignant. Anesthesiology Vol 95, 3, 594-599, 2001. Bina S.Karan SM, Lojeski EW, Mongan PO, Muldoon SM. Prolonging Viability of Swine Muscl Biopsy Specimens in Malignant Hyperthermia Testing. Anesth & Analg Vol 93, 781-786,. 2 Yoshitatsu Sei *, Kathleen L. Gallagher, Saiid Bina, Hadley W. Wyre, Steve J. Holman, Paul A..Pudimat, John W. Daly and Muldoon. S.M: Patients with Malignant Hyperthermia Oemonstn an altered Calcium Control Mechanism in B Lymphocytes. Anesthesiology, Vol 97, 1052-105~ 2002 Rosenberg, J.F. Antognini, S. Muldoon, Testing for Malignant Hyperthermia, Anesthesiology, \ 96,232-237,2002. Nelson, T.E., H Rosenberg, S. Muldoon, Genetic testing for malignant hyperthermia in North America, editorial, Anesthesiology, Vol 100, 212-214, 2004. Sei, Y., N. Sambuughin, S. Muldoon, Meeting Report: Malignant hyperthermia genetic testing i North America working group meeting, Anesthesiology, Vol 100, 2004. 9 Sei, Y., N. Sambuughin, E. Davis, D. Sachs, P.Cuenca, B. Brandom, T. Tautz, H. Rosenberg, . Nelson, S. Muldoon. Malignant Hyperthermia in North America: Genetic Screening of the Thrr Hot Spots in the Type 1 Ryanodine Receptor Gene. Anesthesiology, 2004; 101 (4):824-30. Sei, Y., S. Muldoon. Phenotyping and Genotyping ofthe Ryanodine Receptor-Associated Ger Diseases Using Peripheral Lymphocytes. Current Pharmacogenomics, Vol 2, 203-208, 2004. Muldoon. S., P. Deuster, B. Brandom, R. Bunger. Is there a link between Malignant Hyperther and Exertional Heat Stroke? Exercise and Sports Science Review, 2004; 32(4):174-179. Sambuughin N, Holley H, Muldoon. S, Brandom B, deBantel A, Tobin J, Nelson T, and Goldfar Screening the Entire RYR1 Coding Region for Sequence Variants Associated with Malignant Hyperthermia Susceptibility in the North American Population. Anesthesiology 2005; 102 (3): 5 521. 3ina S, Muldoon S, Cowan G, Karian J, Mongan P, Bunger R. Effects of caffeine, halothane, a :;hloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptabll lormal swine as assessed by microdialysis. Anesthesiology, 2006 January; 104(1): 90-100. Sambuughin N, Brandom BW, Capacchione J, Rosenberg H, and Muldoon S. Toward Updatin! 'Jorth American Malignant Hyperthermia Mutation Panel. Anesthesiology. 107: A503, 2007. lIIuldoon S, Bunger R, Deuster P, Sambuughin N. Identification of Risk factors for exertional hE IIness: a brief commentary on genetic testing. Journal of Sports Rehabilitation. 16: 222-226, 2( ~apacchione J, Muldoon S. Trauma, SIRS, Illicit Steroid Use, and a Questionable MH Reactiol ~nesth and Analg 2009 March; 108(3): 900-3. \/Iuldoon. S., P. Deuster, B. Brandom, R. Bunger. Is there a link between Malignant Hyperther md Exertional Heat Stroke? Current Sports Medicine Reports, March/April 2008. 3ambuughin N, Capacchione J, Blokhin A, Bayarsaikhan M, Bina S, Muldoon S. The ryanodinl 'esceptor type 1 gene variants in African-American men with exertional rhabdomyolysis and nalignant hyperthermia susceptibility. Clin Genet 2009,76: 1218-1224. ~apacchione JF, Sambuughin N, Bina S, Mulligan LP, Lawson TD, Muldoon SM. Exertional 'habdomyolysis and malignant hyperthermia in a patient with RYR1, CACNA 1Sand CASQ1 )olymorphisms. Anesthesiology 2010, 112:239-244. 3ina S, Capacchione J, Muldoon S, bayasaikhan M, Bunger R. Lymphocyte-based determinati ;usceptibility to malignant hyperthermia: a pilot study in swine. Anesthesiology 2010 October; 113(4): 917-24. )K CHAPTERS: 10 Roizen, M.F., Moss, J., and Muldoon. S.M.: The effects of anesthesia, anesthetic adjuvant ~ and surgery on plasma norepinephrine. Norepinephrine: Clinical Aspects, Frontiers of Clini Neuroscience. Williams and Wilkins, 4:289-305, 1984. Muldoon. S.M., Moss, J., Freas, W., and Roizen, M.F.: The effects of anesthetics on the sympathoadrenal system. Clinics in Anesthesiology Vasoactive Amines. W.B. Saunders C 2:227-249,1984. Muldoon. S. M., and Carlin, H.M.: Clinical Assessment of Malignant Hyperthermia Patients. International Anesthesiology Clinics, Malignant Hyperthermia. Martinus Nijhoff Publishing, 1987. Muldoon. S.M., Boggs, S.D., and Freas. W.: Malignant Hyperthermia. Textbook of Critical Care(2nd Ed). Shoemaker, (Ed), W.B. Saunders Co., 1989. Muldoon. S.M., and Karan, S.: Malignant Hyperthermia: an Update. Current Reviews in Cli Anesthesia. 8(5), 1990. Muldoon. S.M., and Karan S.M.: Hyperthermia and Hypothermia. Principles and Practice c Anesthesiology, V. 2. Rogers, M.C., Tinker, J.H., Covino, B.G., Longnecker, D.E. (eds), M 99,1991. Karan, S., Muldoon. S.M.: Anesthesia for Combat Casualty Care. Textbook of Military Mec V. 11. Grandy, Condon, (eds), 1991. Muldoon. S.M.: Muscle Disease, Malignant Hyperthermia and Myasthenia. Current Opinic Anesthesiology. 6:578-581, 1993. Blank, J.W., and Muldoon. S.M.: Clinical Perspective on Malignant Hyperthermia. Problen Anesthesia. 8(1):137-47,1994. Karan, S.M., and Muldoon. S.M.: Malignant Hyperthermia In Anesthesia and Perioperative of the Combat Casualty. Textbook of Military Medicine. Zajtchuk R, Bellamy RF., (eds), Office of The Surgeon General, U.S. Department of the Army and Borden Institute, 29:811- 1995. Karan, S.M., Lojeski, E.W., and Muldoon. S.M.: Malignant Hyperthermia. Atlas of Clinical Anesthesiology, V. 4. Tremper, K., Miller, R (eds), Current Medicine, 9:9.1-9.13,1997. Karan, S.M., Muldoon.S.M., and Lojeski, E.W.: Hyperthermia and Hypothermia. Principles Practice of Anesthesiology, V. 2(2nd Ed). Longnecker D.E., Tinker, J.H., Morgan, G.E. (ed Mosby, 94:2426-2450; 1998. Gronert GA, Pessah IN, Muldoon S, Tautz T: Malignant Hyperthermia. Anesthesia, 6th Edij Miller R (ed), 2004. 11 Muldoon S, Sambuughin N, Voelkel M, Bunger R, Grocott HP, Sulzer C. Chapter 89: Maligr Hyperthermia, Thermoregulation, and Perioperative Hypothermia. Anesthesiology (text bor Longnecker DE, Brown DL, Newman MF, Zapol WM. (eds). Mc-Graw-HiIl2008. ;TRACTS: Muldoon, S.M., Lorenz, R.R., and Van Dyke, R.A.: Effect of halothane on adrenergic neurotransmission in isolated venous smooth muscle. Fed Proc 33:396, 1974. Muldoon, S.M., and Vanhoutte, P.M.: Evidence for dual action of etidocaine on adrenergic transmission in isolated venous smooth muscle. Pharmacologist 17:200, 1975. Muldoon. S.M., and Vanhoutte, P.M.: Alpha adrenergic blocking effect of droperidol on isol, pulmonary arteries and cutaneous veins of the dog. Fed Proc 18:209, 1976. Rorie, O.K., and Muldoon. S.M.: Effect of progesterone and estrogen on the reactivity of isolated blood vessels. The American Heart Association Meeting, 1976. Muldoon. S.M., and Tyce, G.M.: Metabolism of 3H norepinephrine (NE) in isolated canine saphenous veins. Fed Proc 3858:950,1977. Muldoon. S.M., Vanhoutte, P.M., and Tyce, G.M.: Prevalence of the reduced metabolites 0 norepinephrine in sympathetically innervated veins. Sixth International Meeting of the International Society for Neurochemistry, 1977. Tyce, G.M., Rorie, O.K., and Muldoon, S.M.: Specific activities of retained and released norepinephrine in an isolated vascular prepar-ation with prelabeled transmitter stores. SeVE Meeting of the International Society of Neurochemistry, Jerusalem, Israel, 1979. Huot, S., Muldoon. S.M., Pamnani, M., Clough, D., and Haddy, F.J.: Effects of sodium vanadate (Na3V04) on wall tension and Na:tK+ pump activity in isolated canine saphenous, Fed Proc 38:1036, 1979. Doblar, D.O., Baskoff, J.D., Reynolds, R.J., Muldoon. S.M., and Watson, R.L.: Epidural Morphine for postoperative analgesia: Effect on control of Breathing in man. Clin Res 28(3):653A, 1980. Doblar, D.O., Reynolds, R.J., Baskoff, J.D., Muldoon. S.M., and Watson, R.L: Effect of Epic Morphine on Control of Breathing in Man. APS Physiologist 23(4):139, Aug, 1980. Freas, W., and Muldoon. S.M.: Drug and ionic influence on norepinephrine metabolism in tl canine saphenous vein. Physiologist 23(4):17, 1980. Doblar, D.O., Abbrecht, P.H., Watson, R.L., and Muldoon. S.M.: Epidural morphine: Effec1 Control of Breathing in Man. PGA 36, 1980. 12 Muldoon, S.M., Rorie, D.K., and Tyce, G.M.: Effect on L-dopa on Adrenergic Transmission isolated Canine Saphenous Veins. Pharma-cologist 202:428, 1980. Otto, J., Muldoon. S.M., and Watson, RL.: Effect of Morphine on Vascular Reactivity and Endogenous Norepinephrine Release in Innervated Canine Saphenous Veins. Pharmacolc 202:196,1980. Keefe, W.E., Bernhard, W. N., Barth, M., Muldoon. S.M., Abbrecht, P.H" Turndorf, H., and Watson, RL.: Physiologic Studies Using High Frequency Oscillations (HFO) AUA, April19i Muldoon. S.M., Otto, J., and Thoa, N.B.: Interaction Between Morphine and Alpha Adrener Agents on Evoked Release of Norepine-phrine (NE) from Isolated Canine Saphenous Vein. Fed 'Proc 40:45, 1981. Todd, R, Keefe, W.E., Muldoon. S.M., Watson, RL., and Thoa, N.B.: Determination of Pia and CSF Morphine (M) Levels by Liquid Chroma-tograph and Electrochemical Detection (LCEC). Fed Proc 40:861, 1981. Keefe, W.E., Abbrecht, P.H., and Muldoon. S.M.: Effect of plasma on nore-pinephrine accumulation in the canine saphenous vein. Physiologist 24(4):32, 1981. Freas, W., and Muldoon. S.M.: Effect of plasma on norepinephrine ac-cumulation in the ca saphenous vein. Physiologist 24(4):32, 1981. Muldoon, S.M., Otto, J., and Freas, W.: Effect of Morphine on Venous Reactivity and Endogenous Norepinephrine (NE) Release in Canine Saphenous Veins. Eighth Meeting of International Society for Neurochemistry, Nottingham, U.K., 1981. Muldoon. S.M., Otto, J., Keefe, W.E., and Deuster, P.A.: Diagnostic studies in malignant hyperthermia (MH). Third International Workshop on Malignant Hyperthermia, Banff, Alben Canada, 1982. Freas, W., Carrillo, A., DiMarzio, L., and Muldoon. S.M.: Partial Characterization of a Factc Plasma that Inhibits 3H-Norepinephrine Accumulation in the Canine Saphenous Vein. Fed 41:1001,1982. Freas, W., Carrillo, A., and Muldoon S.M.: Plasma factors cause augmentation of responSE electrical stimulation in canine saphenous vein. Fed Proc 42(3): 639, 1983. Muldoon. S.M., Donlon, M.A., Todd, R, Helgeson E.A., and Watson, RL.: Plasma histamir levels in nalbuphine and morphine treated dogs. Fed Proc 42(4): 3586, 1983. McCarthy, E.J., Abbrecht, P.H., Langston, J., Keefe, W.E., and Muldoon. S.M.: The alveol, uptake of halothane using high frequency oscillation. Fed Proc 68:5, 1983. 13 Blanck, T.J.J., Fisher, Y.I., and Muldoon, S.M.: Novel low molecular weight proteins in malignant hyperthermic muscle. Anesthesiology 59(3): A259, 1983. Deuster, P.A., Bockman, E.L., and Muldoon, S.M.: Differential halothane response in Type soleus, and Type II gracilis muscle of the cat. Anesthesiology 59(3): A367, 1983. Muldoon, S.M., Kyle, R, and Freas, W.: Halothane causes a fiber type dependent respons rat skeletal muscle. Fed Proc 43(3):532, 1984. Donlon, M.A., Muldoon, S.M., Swindall, B.T., Anselmo, D., and Freas, W.: Changes in plasl histamine and catecholamine levels following morphine administration in dogs. Fed Proc 43:743; 1984. Deuster, P.A., Biscardi, H.M., Bockman, E.L., and Muldoon, S.M.: Verapamil blocks halothc induced contractures in cat soleus (Type I) muscle. Fed Proc 43:1041, 1984. Hart, J., Warner, E., McKenzie, J., and Muldoon, S.M.: Neuroeffector and contractile funcH the tail artery from streptozotocin diabetic rats. Fed Proc 43: 1041, 1984. Freas, W., McCeney, K.L., Green, R, and Muldoon, S.M.: Purification of an endogenous 31 Norepinephrine uptake inhibitor in canine plasma by column and thin layer chromatography Fed Proc 43:1081, 1984. Muldoon, SM, Hart, J., Bowen, K., and Freas, W.: Effects of halothane on canine arteries: of the endothelium. Fed Proc 44:1375, 1985. Hart, J.L., Freas W., Muldoon, SM, McKenzie, J.E., Bowen, K., and Wessel, R: 3H_ Norepinephrine and metabolite release from the tail artery of the streptozotocin diabetic rat. Proc 44(5): 1657, 1985. Freas, W., Todd, R.A., Tyce, G.M., and Muldoon, SM: Effect of etidocaine on spontaneous evoked release of norepinephrine from rat brain synaptosomes. Fed Proc 45(5): 1635, 198! Freas, W., Thompson, D.A., Hart, J.L., and Muldoon, SM: Norepine-phrine accumulation b~ rat caudal artery in the presence of hypertensive plasma. Fed Proc 45(3):524, 1986. Hart, J.L., Freas, W., and Muldoon, SM: Vascular neuroeffector activity in the rat during pregnancy. Fed Proc 45(3):434, 1986. Hart, J.L., Renfro, J.B., Freas, W., and Muldoon, SM: Norepinephrine accumulation and histofluorescence of vessels from streptozotocin diabetic rats. Fed Proc 46(3):407, 1987. Hall, D. B., Freas, W., Bowen, K. A., Wessel, R F., and Muldoon, SM: The effects of diaze~ on the peripheral adrenergic neuroeffector junction of the dog. Fed Proc 46(3):553, 1987. 14 Freas, W., Thompson, D.A., Hart, J.L., and Muldoon. SM: Effect of various phospholipids 0 3H-norepinephrine accumulation by the rat caudal artery. Fed Proc 46(3):653, 1987. Freas, W., Hart, J.L., Golightly, D., McClure, H., Rodgers, D.R., and Muldoon. SM: Effect 0- photoradiation on contractile properties of isolated blood vessels. FASEB J 2(4):A756, 198: Edwards, T.L., Freas, W., McGehee J., and Muldoon. SM: Effect of isoflurane on the vaSCL neuroeffector junction. 9th World Congress of Anesthesiologists. 1 :A0234, 1988. Hall, D., Freas, W., McClure H., Swindall, B., and Muldoon. SM: The effect of a fentanyl/diazepam combination on neurovascular function. 9th World Congress of Anesthesiologists. 1 :A0234, 1988. Freas W., Hart, J., Golightly, D., McClure, H., and Muldoon. SM: Effect of halothane on the response of blood vessels to laser activated photo-sensitizers. 9th World Congress of Anesthesiologists, 1 :A0258, 1988. Freas, W., Hart, J., Golightly, S., McClure, H., Rodgers, D.R., and Muldoon. SM: Alteration normal vascular smooth muscle activity following laser photodynamic therapy. Presented a Third Annual Contractors Meeting, Abstract #35, Biomedical and Material Science Applicati of Free Electron Lasers, Salt Lake City, Utah, 1988. Freas, W., Hart, J., Golightly, D., McClure, H., Rodgers, D.R., and Muldoon. SM: Contractil properties of reactive oxygen intermediates on rat caudal arteries. FASEB J 3(4):A1231, 1! Cress, L.W., Freas, W., Haddy, F.J., and Muldoon. SM: Bufalin increases norepinephrine release in innervated canine saphenous vein. FASEB J 3(3):A258, 1989. Lineberry, P., Stevens, R.A., Arcario, T, Cress, L.W., and Muldoon. SM: Epidural anesthesi blocks the catecholamine response to hypoxemia in awake dogs. Accepted for presentatio the American Society of Anesthesiologist, Annual Meeting, Oct 1989. Nagel, J., LLave, R., McClure, H., Cress, L., Freas, W., and Muldoon. SM: Halothane attenuates reactive oxygen intermediates' impairment of canine vascular function. Anesth j 70:S10s450, 1990. Freas, W., Cress, L., Nagel, J., Hart, J., Llave R., and Muldoon. SM: Effect of reactive oxyg intermediates on norepinephrine overflow from rat caudal arteries. FASEB J 4(4):A975, 19 Cress, L., Cianci, S., Freas, W., Haddy F., and Muldoon. SM: Bufalin increases plasma norepinephrine in the anesthetized rat. FASEB J 4(4):A1130', 1990. Boggs, S., Lake R., Muldoon. SM, and Cress, L.: Norepinephrine clearance rate and relea rate in malignant hyperthermic humans. Anesth Analg 70:S1-S450, 1990. 15 Jing, M., Hart, J., Bina, S., Freas, W., and Muldoon, SM: Effect of halothane on nitroglycer induced relaxations. FASEB J 6(4):A207, 1992. Freas, W., Llave, R, and Muldoon, SM: Inhibition of cold induced vasoconstriction by halo following generation of reactive oxygen intermediates. FASEB J 6(4):A210, 1992. Bina, S., Freas, W., Hart, J., Jing, M., Gantt, R, and Muldoon, SM: Interactions between n oxide and halothane. FASEB J 6(5):A5375, 1992. Muldoon, SM, Jing, M., Freas, W., Hart, J., and Van Dyke, RA.: Proposed Mechanism for Attenuation of Endothelial Induced Relaxation by Volatile Anesthetics. Anesthesiology 77(3A):A687, 1992. Lenczyk, M.E., Karan, S.M., Freas, W., and Muldoon, SM: The Effects of Ischemia/Reperfl Injury on Halothane and Caffeine Contracture Tests in Rats. FASEB J 6(4):A210, 1992. Petty, RH., Stevens, RA., Burge, J.R, Gantt, RM., and Muldoon, SM: Effect of 2- Chloroprocaine on Muscle Contracture Tests in Rat. FASEB J 6(4):A210, 1992. Karan, S.M., Lojeski, E.W., Boedeker, B.H., Freas, W., Haynes, D.H., and Muldoon, SM: Microencapsulated Dantrolene vs. Oantrolene: Dose-response to Muscular Twitch in Rats. lARS 1992. Muldoon, SM, Ledvina, M.A., Jing, M., and Hart, J.L.: Effects of Inhalation and Intravenouf Anesthetics on Oiaspirin Crosslinked Hemoglobin TM-Induced Contractions of Porcine Pulm( Veins. Anesthesiology 81 :A32 , 1994. Bina, S., Hart J.L., and Muldoon, SM: Comparative Effects of Exogenous Nitrovasodilators cGMP levels in different canine blood vessels. FASEB J 8:A314, 1994. Jing, M., Hart, J.L., Bina, S., Verma, A., and Muldoon, SM: Effect of Anesthetics on Carbon Monoxide Induced Relaxation of Rat Aortae. FASEB J 8:A32, 1994. Bina, S., Jing, M" and Muldoon, SM: Pig Intact Pulmonary Vein (IPV) Contains Higher Nitril Oxide Synthase (NOS) and Lower Levels of cGMP Phosphodiesterase (POE) than Intact Pulmonary Artery (IPA). FASEB J 9:A32, 1995. Hart, J.L., Ledvina, M.A., and Muldoon, SM: Oiaspirin Crosslinked Hemoglobin (DCLHb™) Effects on Isolated Blood Vessels. FASEB J 9:A26, 1995. Jing, M., Hart, J.L., Bina, S., and Muldoon, SM: Effect of Anesthetics on Carbon Monoxide induced Relaxation of Rat Aortae in Low Oxygen Tensions. FASEB J 9:A615, 1995 Nguyen, H., Bina, S., and Muldoon, SM: Temporal Changes in Nitric Oxide (NO) Levels in Awake, Endotoxemic Rats. FASEB J 9:A26, 1995. 16 Karan S.M., Bina, S., Lojeski, E.W., Haney, J.A, and Muldoon. SM: Effect of Tension, Temperature and Time on the Halothane Contracture Test for Malignant Hyperthermia. Anesthesiology 83:A355, 1995. Jing M., Beardsley, D., Panico, F., Hart, J.L., and Muldoon. SM: Diaspirin Crosslinked Hemoglobin Does Not Alter Isolated Human Umbilical Artery or Vein Tone in the Presence I Absence of Halothane. Anesthesiology 83:A644, 1995. Hart J.L., Ledvina, M.A, Muldoon. SM: Species Differences in Responses of Isolated Blood Vessels to Diaspirin Crosslinked Hemoglobin (DCLHb TM). FASEB J 10:A603, 1996. Jing, M., Ling G., Verma A, and Muldoon. SM: Incubation Time: A Key for Halothane to Attenuae NO-induced cGMP Formation in Vascular Smooth Muscle. FASEB J 10:A157, 1! Ledvina, M.A., Hart, J.L., Macdonald, V.W., and Muldoon. SM: Comparison of the Vasculal Effects of Hemoglobin Ao (HbAo) and Diaspirin Crosslinked Hemoglobin (DCHLb™). FASE 10:A603, 1996. Bina S., Jing, M., Hart J.L., Ledvina, M.A, and Muldoon. SM: Halothane Inhibits ExogenOi NO-Induced Activation of Guanylate Cyclase in Porcine and Canine Blood Vessels. FASEI 10:A332, 1996. Panico, F.G., Pudimat, P.A., Nusbaum, J., Muldoon. S.M. and Goldstein, R.: Pulmonary A Pressure Rises with Low-Dose Diaspirin Crosslinked Hemoglobin (DCLHb TM) in Swine. FASEB J 10:A100, 1996. Nary, J., Ling, G., Lojeski, E., Muldoon. SM.: Truamatic brain injury in rats: histopathologic effects of hemodilution with diaspirin crosslinked hemoglobin. Anesthesiology 88:S105, 19~ Bina, S., Muldoon. SM., Hai, T.T., Nelson, D.J.: an attempt to alter the physiological propert of diaspirin cross-linked hemoglobin. FASEB, April, 1998 Jing, M., Verma, A, Muldoon. SM; Purification of soluable guanylyl clyclase from pig lung c effects of halothane on sGC activity. FASEB, April, 1998 Jing M, Verma A, Muldoon SM: Effects of Halothane on the Activity of Purified Soluble Gual Cyclase (sGC) from Porcine Lung. Anesthesiology 89:A182, 1998 Sefton W. Pudimat P, Bina S, Muldoon SM: Inhaled Nitric Oxide Attenuates Diaspirin Crossl Hemoglobin Induced Increases in Pulmonary Arterial But Not Systemic Arterial Pressure. Anesthesiolgoy 89: A383d, 1998 Sei Y. Fletcher JE, Nelson T. Gallaher KL, Muldoon SM: Detection of Mutation in the Ryanc Receptor type I Gene in Patients with Malignant Hyperthermia in North America, Anesthesi( 91: A337, 1999 17 Sei Y, Gallagher KL, Bina S, Pudimat P, Muldoon SM: Expression of Type 1 Ryanodine Ree and increased Calcium Response to Caffeine and 4 Chloro-M-Cresol in B lymphocytes frolT Malignant Hyperthermia Patients, Anesthesiology 91 :A338, 1999 Mongan, PD, Bina, s, Fontana, JL, Bunger, R, Muldoon.SM: Pyruvate, But Not Lactate, Enhances contraction of Isolated Porcine Carotid Arteries, Anesthesiology 91 :A650, 1999 Yoshitatsu Sei *, Kathleen L. Gallagher, Saiid Bina, Hadley W. Wyre, Steve J. Holman, Paul A..Pudimat, John W. Daly and Muldoon. S.M: Patients with Malignant Hyperthermia Demom an altered Calcium Control Mechanism in B Lymphocytes. Anesthesiology, Vol 97, 1052-1( 2002 Rosenberg, J.F. Antognini, S. Muldoon, Testing for Malignant Hyperthermia, Anesthesiology 96,232-237, 2002. Brandom BW, Sei Y, Sambuughin N, Muldoon S. MH Diagnostic Efforts in North America: 21 Update. The North American MH Registry, University of Pittsburgh, Uniformed Services University of the Health Sciences, and Barrows Neurologic Institute. 21 st Annual meeting of 1 th th European Malignant Hyperthermia Group, May 16 - 18 , 2002. Sei, Y., S. Muldoon. Phenotyping and Genotyping of the Ryanodine Receptor-Associated Genetic Diseases Using Peripheral Lymphocytes. Current Pharmacogenomics, Vol 2, 203-~ 2004. Nelson, T.E., H Rosenberg, S. Muldoon, Genetic testing for malignant hyperthermia in Nortr America, editorial, Anesthesiology, Vol 100, 212-214, 2004. Sei, Y., N. Sambuughin, S. Muldoon, Meeting Report: Malignant hyperthermia genetic testin North America working group meeting, Anesthesiology, Vol 100, 2004. Muldoon S, Deuster P, Brandom B, Bunger R. Is There a Link between Malignant Hyperthe and Exertional Heat Illness? Exercise and Sports Sciences Review 2004; 32(4):174-179.20 101 :824-30. Sambuughin N, Holley H, Muldoon. S, Brandom B, deBantel A, Tobin J, Nelson T, and Gold L. Screening the Entire RYR1 Coding Region for Sequence Variants Associated with Malign Hyperthermia Susceptibility in the North American Population. Anesthesiology 2005; 102 (3) 515-521. Bina S, Muldoon S, Cowan G, Karaian J, Mongan P, Bunger R. Effects of ryanodine recept< agonists on intramuscular lactate-pyruvate in malignant hyperthermia-susceptible swine as assessed by microdialysis. Anesthesiology, submitted for publication. Brandom B, Muldoon S. Estimation of the Incidence of Malignant Hyperthermia using a Cap Recapture Method in the USA. Anesthesiology, submitted for publication. 18 American Association of Orthopedic Surgeons. Influence of sex and gender on Musculoskele , Health: Workshop Report. Manuscript in process. McKinney LC, Mullen SP, Butler T, Kline MG, Muldoon SM. Calcium release from ryanodine sensitive stores in lymphocytes can be used to assay RYR1 function in Malignant Hyperthern Association of University Anesthesiologist. Baltimore, 2005. Torp KD, Brandom B, Capacchione JF, Voelkel M, and Muldoon SM. Caffeine halothane contracture test and ryanodine receptor type 1 analysis in patients who experienced MH episodes. American Society of Anesthesiologists. 2005. Sambuughin N, Brandom BW, Capacchione J, Rosenberg H, and Muldoon S. Toward Updati the North American Malignant Hyperthermia Mutation Panel. Anesthesiology. 107:A503, 200' Muldoon S, Deuster P, Voelkel M, Capacchione J, and Bunger R. Exertional Heat Illness, Exertional Rhabdomyolysis and Malignant Hyperthermia: Is There A Link? Current Sports Medicine Reports, March/April 2008. Hirsey-Dirksin J, Brandom, B, Muldoon, SM. and Rosenberg, H. Genetic Testing to Evaluate Malignant Hyperthermia Susceptibility (MHS). Recently Accepted. Capacchione J, Muldoon S. Trauma, SIRS, Illicit Steroid Use, and a Questionable MH React Anaes Analg. 2009 Mar; 108(3): 900-3. 19 ~.~ .~,.: BRICHAM AND _ HARVARD \ . 1 \NOMEN'S HOSPITAL V IVIEDrCAL SCHOOL ""rI Department oi Anesthesiology, Perioper.ltive and Pain 1\1edicine P.D. Allen, M.D., Ph.D. ;; }'!,lnl i~ ~t[~,(,t ~;,,,t, '11. "L1",vhU,t'th ()21 i" il'L !li7 7.;'~-7)~-t 1,.1\: h17 7~2-()l)':':7 I ·1l1"iI: ,,11"11:' /"ll'.b\\ h.lldl \ ,lrd.l'ti" Oxtober 19'" 2010 Anthony R. Artino, Jr., PhD, FAsMA, CAsP Lieutenant Commander, MSC, US Navy Assistant Professor of Preventive Medicine & Biometrics Assistant Professor of Medicine Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814-4712 Re: Sheila Muldoon M.D. Nomination for Carol J. Johns Medal Dear Lt. Cdr. Artino: It is with great pleasure that I write this letter of support for Dr. Sheila Muldoon's nomination to receive the Carol J. Johns Medal. In my opinion Dr. Muldoon is the epitome of the spirit of Dr. Johns, excelling in all three areas in which you presented in your letter which I will address in order. 1. furthering the welfare and excellence of the USU faculty: Dr. Muldoon has acted as a mentor to generations of trainees, and faculty at the Uniformed Services University of the Health Sciences looking out for their welfare and stimulating to achieve the best possible both in her role as an outstanding Chairperson of the Department of Anesthesia, and then after her retirement as chair in her role as a clinical and basic science research mentor. I have had the opportunity to see her in action in the latter role and have observed that she has selflessly given her time in mentoring and promoting the careers of her junior faculty and fellows. 2. promoting outstanding educational programs for the students: As Chairperson of Anesthesia one of Dr. Muldoon's primary concerns was the training of Uniformed Services University of the Health Sciences medical students and residents in training. She set up several innovative teaching programs which were state of the art for clinical teaching. In addition she stimulated both groups to think not only of the clinical aspects of medicine but also to excel in medical science. 3. advancing the reputation of the University locally, nationally, and internationally. It is in this role that I know Dr. Muldoon the best. I have known her as a colleague as one of the leading authorities on Malignant Hyperthermia (MH) in the world. She is frequently invited a plenary speaker and participate at National and International meetings of MH Societies, International Anesthesia Meetings, and International meeting of non-anesthesia societies advancing the reputation of the Uniformed Services University of the Health Sciences. She organized and has acted as a director of the US MH patient registry, and has been a charter member of MHAUS, which is the national society for MH. She has been a co organizer of several symposia. In addition she has advanced the reputation of the Uniformed Services University of the Health Sciences by being the director of PARTNERS,--- - HealthCare System M, an important MH testing center based at USUHS that is one of less than 5 remaining centers in the USA. Because of this she was chosen to participate in a NIH/NIAMS funded program project whose objective was to discover the mechanisms that allow these patients to lead relatively normal lives, unless challenged by exposure to anesthesia. Based on all that I have said above, I feel that there could be no other candidate who has given so much of their lives to the well being and promotion of the Faculty, Students and Reputation of the Uniformed Services University of the Health Sciences and that for this reason Dr. Sheila Muldoon is very much deserving of this honor. If I can be of any further assistance to the selection committee please do not hesitate to call or e-mail me any time. Sincerely yours, ~~-- Paul D. Allen, M.D.,- Ph.D. Professor of Anaesthesia ~ ---- PARmERS, HealthCare System Mer Timothy B. Bentley, Ph.D. Deputy Lead, Force Health Protection Program Office of Naval Research, Code 34 875 N. Randolph St. Arlington, VA 22203 Anthony R. Artino, Jr., PhD, FAsMA, CAsP Ueutenant Commander, MSC, US Navy Assistant Professor of Preventive Medicine & Biometrics Assistant Professor of Medicine Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814-4712 September 21, 2010 Dear LCDR Artino: It is my sincere pleasure to support the nomination of Dr. Sheila Muldoon to be the next recipient of the Carol J. Johns Medal. She is an outstanding choice for the award as she very clearly exemplifies the three principles of excellence demonstrated by Dr. Johns during her career. I have known Dr. Muldoon for about ten years while she served as a professor and chairman of the Department of Anesthesiology at USUHS. During this period I was a research scientist at WRAIR and I had the opportunity to collaborate with a number of faculty members in Anesthesiology. It was through these connections that I met Dr. Muldoon and I have to say it was for me a very fortuitous introduction. Her knowledge, professional contacts and scientific acumen were freely shared with us and they proved to be instrumental in the success of our projects. Dr. Muldoon made suggestions, listened to my complaints and lifted my spirits when the research was just a little too frustrating. She continued her support as I became an adjunct faculty member in the Anesthesiology department and helped me to integrate with other faculty members. Dr. Muldoon has identified and brought to USUHS numerous excellent faculty members, post doctoral fellows, visiting faculty, guest speakers and technicians. She provides an excellent perspective on the development of USUHS as well as the formation and direction of a teaching and research department. Time after time I have watched her interact with colleagues, providing advice, knowledge and crafty guidance in overcoming some obstacle. She has made a definitive contribution to the establishment, growth and maintenance of the high quality faculty at USUHS. Dr. Muldoon is a dedicated, passionate but patient teacher. In the ten years I have known Dr. Muldoon I have never had a conversation or attended a meeting or seminar with her in which I didn't learn something from her. She listens carefully and always provides useful insights and excellent analysis. Her outstanding teaching reaches the medical and graduate students but also the post-docs, junior faculty and technicians. She has inculcated in a number of young people a sense of confidence and desire to go on furthering their education and careers. The fine reputation that USUHS has as both a medical school and a research university is certainly greatly enhanced by having Dr. Muldoon on the faculty. She is a world expert on malignant hyperthermia and selflessly contributes her time and effort to guiding patient clinical testing and education. She is a renowned researcher and has consistently brought in research funding. In conclusion I have to say I really like Sheila. I suppose likeableness isn't one of the criteria of the Johns Award but it certainly is a joy to meet up with her. I know that she is going to teach me something about anesthesiology or hyperthermia; she is going to ask me to explain my current work and then challenge me and make me think; she will set problems in perspective and provide the suggestions that help me move forward. Dr. Sheila Muldoon is an exemplary member of the USUHS community and I fully support her as the next recipient of the Johns Medal. Sincerely yours, Timothy B. Bentley Anthony Artino, Ph.D. Secretary-Treasurer, Faculty Senate USUH 4301 Jones Bridge Rd Bethesda, MD 20814 RE: Nomination of Dr. Muldoon for the USU's Carol Johns Medal Dear Dr. Artino, I am fully supporting nomination of Dr. Muldoon for the Carol Johns Medal. I have been collaborating with her for over 20 years in diversified projects. She is very well known nationally and internationally for her contributions in malignant hyperthermia research and diagnoses. In addition, she is also very well known for her work in catecholamine related and blood substitute research. Her success to secure extramural grants has been continuous and impressive during past 30 years. Finally, her management skill is also very well established at UHUHS for being department of anesthesiology chair person and being member of various committees for decades. Saiid Bina, Ph.D. Research Assistant Professor Department of Anesthesiology USUHS 4301 Jones Bridge Road Bethesda, MD 20814 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA. MARYLAND 20814-4712 _.usuhs.mil October 21,2010 Roopa Biswas, PhD Assistant Professor Graduate School of Nursing & School of Medicine, B4024 Uniformed Services University 4301 Jones Bridge Rd Bethesda, MD 20814 Anthony Artino, PhD Secretary-Treasurer, Faculty Senate Uniformed Services University of the Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814 RE: Support Letter for Dr. Muldoon Dear Dr. Artino, It is my pleasure to write this support letter for Dr. Sheila Muldoon. I have known Sheila since 2005, when I joined the School of Nursing at USUHS. I came to know her as a colleague, scientist, and teacher. My laboratory was located adjacent to Dr. Muldoon's. She has been an excellent and very supportive colleague. We often engage in very insightful scientific discussions on our mutual projects and potential collaborations. Sheila is an excellent scientist as is evident from her publications in high impact journals. Her expertise and contributions in research on Malignant Hyperthermia is extremely well recognized nationally as well as internationally. Dr. Muldoon's insightful lecture on Malignant Hyperthermia to the Nurse Anesthesia students in the Graduate School of Nursing has attracted many students towards performing a research project on this topic. She is a dedicated teacher and an excellent lecturer. It is an honor to nominate Dr. Muldoon for the Carol J. John Medal. She is indeed deserving of this award. Sincerely, RoCrP Ov 0t ~n Roopa Biswas, PhD University of Pittsburgh Depm1mcnt ofAnesthesiology and Critical Cm'e IHedicine UPMC Mercy Hos~UI Ennire Bldg. (B). 8 Fh B,."dum, M.D. Room 8522·3 AnesthesIOlOgy 1400 Locust Street Pittsburgh. PA 15219 Anthony R. Artino, Jr., PhD, FAsMA, CAsP Secretary-Treasurer, Uniformed Services University Faculty Senate Lieutenant Commander, MSC, US Navy Assistant Professor of Preventive Medicine & Biometrics Assistant Professor of Medicine Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814-4712 October 19, 2010 To Lieutenant Commander Artino and the Faculty Senators of the Uniformed Services University, I am writing with great enthusiasm in support of the award of the Carol J. Johns Medal to Sheila M. Muldoon, M.D., Professor of Anesthesiology at the Uniformed Services University of the Health Sciences (USU). I began to work closely with Dr. Muldoon in 1999 on the genetics of malignant hyperthermia (MH) susceptibility. As a pediatric anesthesiologist, my interest in the syndrome of MH increased during the early 1980s when the question of MH susceptibility arose in one of every 100 anesthetized children who received halothane and succinylcholine. At that time the only diagnostic test which could confirm MH susceptibility was the bioassay of muscle, the caffeine halothane contracture test (CHCT). Therefore I knew that Dr. Muldoon was the Director of the MH Diagnostic Center at USU where CHCT is still performed. In 1991 I began volunteering as a consultant for the MH Hotline, sponsored by the not-for-profit Malignant Hyperthermia Association of the United States (MHAUS). The more time that I put into guiding anesthesiologists caring for MH susceptible people the more I learned from MH susceptible families and the more I learned of the scientific work on MH being performed at USU because of Dr. Muldoon's efforts. I eagerly performed the paper work required and set up to enlist subjects for Dr. Muldoon's study of MH genetics in families from my geographic area. I was pleased to be able to participate in research that could help families with this condition as well as the practicing anesthesiologists. Dr. Muldoon had constructed a program to study the genetics of MH in people living in North America. She had worked with and learned from researchers in Europe, Canada, Australia, New Zealand and South Africa. She also worked closely with neurologists, exercise physiologists and pathologists in USU. She devoted not only her time, but her personal resources, to bring the necessary scientists to this project. The shared goal, better understanding of the \\1 UPMC-PSD-OO 1\Anesthesiology$\MHReg\BWB\BWB Correspondence\letters of recommendation\1 0 1021 Johns award. doc genetic substrate of MH susceptibility, was motivated by the desire to help families who had experienced a preventable MH death. The current clinical tests of MH susceptibility which consist of screening the ryanodine receptor type one (RYR1) gene rely heavily on the work performed by Dr. Muldoon and her colleagues over decades. Many anesthesiologists turned away from research in MH, this seemingly uncommon pharmacogenetic disease peculiar to inhaled anesthetics. MH seemed to present only rarely. More research publications could be produced faster in other areas of study, but Dr. Muldoon had the wisdom to see that investment in the maintenance of scarce resources can yield very important results. She lobbied fiercely with MHAUS to obtain continued support of the North American MH Registry (NAMHR), initiated by Dr. M.G. Larach in 1989 at Penn State in Hershey, PA. When earlier MH Registry Directors moved out of academic medicine, Dr. Muldoon assumed the directorship of the NAMHR until competitive applications could be reviewed and a stable, supportive location identified. She worked with the MHAUS Board of Directors and the Dean of the Medical School at the University of Pittsburgh to secure the future of the NAMHR. Her administrative wisdom was crucial to the NAMHR. It was at this point in time, in 2000, that I assumed Directorship of the NAMHR. Dr. Muldoon inspired me to work with the limited resources available to assist affected families and promote research by young clinicians based on NAMHR data. As a result, since 2007, four major publications and a case report from the NAMHR have appeared in peer-reviewed anestheSiology journals. One of these papers was accompanied by a supportive editorial written by the most active researcher in the largest MH DiagnostiC Center in Europe. Dr. Muldoon was NOT a co-author on any of these papers, yet none of this work could have been done without her previous accomplishments. The NAMHR is a research repository for the purpose of furthering any type of research on the syndrome of MH. Our interest in genetiCS was formally supported by the larger Anesthesiology community when the young scientist sponsored by Dr. Muldoon, Dr. N. Sambuughin, was awarded a grant from the Anesthesia Patient Safety Foundation. Thereafter Dr. Muldoon was able to secure funding as part of a NIH program project as well as from MHAUS. These are significant accomplishments, for USU, for Dr. Muldoon and for all the individuals interested in the MH syndrome. No one else in the MH community in the USA was as successful as Dr. Muldoon was at organizing support for new diagnostic tests of MH susceptibility, including the RYR1 screen. The NAMHR contributed actively to subject recruitment for the most recent stage of the study of MH genetics in North America. What I have learned from these subjects motivates me to continue Dr. Muldoon's work focused on helping individuals and families with MH susceptibility. We are going to demonstrate that there is a chronic component to the MH syndrome. MH is not only a pharmacogenetic disease related to potent inhalation anesthetics, but a chronic condition that should be treated. It is unlikely that this expanded understanding of pathophysiology could be accomplished without the strong foundation that Dr. Muldoon produced. At present Dr. Muldoon is preparing reports incorporating the \\ JUPMC -PSD-OO I \AnesthesiologyS\MHReg\B WB\BWB Correspondence\leners of recommendation\ I 01021 Johns award. doc biochemical and genetic expertise of colleagues, to demonstrate abnormal RYR1 variants in children who died emergently without exposure to general anesthetics. She could do this only because she offered truly sympathetic support to the affected families and maintained that positive relationship for years, as she invested in the research needed to elucidate the biologic causes of these tragedies. Indeed, because of the clinical diagnostic test of MH susceptibility based on the published studies of MH genetics performed at USU, it is now possible for fulminant, acute MH episodes to be investigated with blood or other tissue transported through the mail. Anesthesiologists who wondered if the event they just experienced was MH have been able to confirm that when known MH causative mutations were found in their patients. These patients have been referred to the NAMHR, and can be subjects in future clinical trials. Medical examiners investigating recent, unexpected, sudden deaths have been able to demonstrate RYR1 variants during autopsies. With the continued support of the MH Diagnostic Center at USU and the Center for Medical Genetics at the University of Pittsburgh Medical Center, families can investigate their risk of MH more efficiently than was possible in 1980. However, she has taught me to be wary of simple answers. The study of MH genetics has identified a substantial number of compound heterozygotes. How the heterozygote state affects channel function is not simple to predict. But just the fact that there are compound heterozygotes, people who have 2 MH causative RYR1 mutations, implies that the genetic potential to experience MH is likely to be present in close to 1 in 3,000 people. Why fulminant MH episodes are so much less common remains unknown. Dr. Muldoon has connected the practicing anesthesiologists to the biophysicists studying the RYR1 gene and the RYR 1 channel in the laboratory. We look to these scientists to bring us closer to understanding the best advice to give the patients and the anesthesiologists and other physicians. Dr. Muldoon played a major role in organizing the meetings sponsored by MHAUS which introduced new, clinica"y relevant, information to the MH Hotline Consultants. She made sure that her junior colleagues gave presentations at these meetings. She promoted the next generation, not only by supporting research inside her institution, but also by introducing these younger people to the wider world of MH research. After I went with her to several meetings of the European MH Group, I realized that she takes this role for investigators from many parts of the world. Both clinical investigators working on new diagnostic tests of MH susceptibility and laboratory investigators looked forward to talking with her about their work and hearing her approval of their efforts. I know that I have not mentioned all her accomplishments. For example, I have not discussed her role in the recent publication in Anesthesiology from Dr. Bina at USU. He is working on measurement of adenosine as part of a blood based test of MH susceptibility. I know that Dr. Muldoon has been in favor of this project and working with Dr. Bina toward this publication in Anesthesiology, the major journal in this area. \\ 1UPMC-PSD-OO 1\Anesthesiology$\MHReg\BWB\BWB Correspondence\letters of recommendation\! 01 021 Johns award. doc I hope that I have provided here more than ample support for the first and third criteria of the Carol J. Johns Award. All I know of Dr. Muldoon shows her to have continually furthered the welfare and excellence of the USU faculty and to have advanced the reputation of the Uniformed Services University nationally and internationally. Because I have not spent years with her inside USU I will not try to speak to the other criteria. I wish that I had started to work with Dr. Muldoon earlier in my career. It would have been to my benefit and to the overall benefit of research in this area. However, I have learned from Dr. Muldoon that I can make Significant contributions, especially in support of the affected individuals who contact me. She has inspired me to continue to volunteer, as she has done, to support the advance of research in this area by investigators inside and outside my own university. Sincerely, ~0/4CUrctdu../ ffi.D Barbara W. Brandom, M.D. Director of North American Malignant Hyperthermia Registry of MHAUS Professor Anesthesiology Department of Anesthesiology University of Pittsburgh \\1 UPMC -PSD-OO 1\Anesthesiology$\MHReg\BWB\BWB Correspondence\letters of recommendation\1 01021 Johns award.doc UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. eDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 12 October 2010 Dear Sirs: It is my distinct honor to write this letter of recommendation in support of Dr. Sheila Muldoon, a nominee for the Carol J. Johns Medal. While Dr. Muldoon has made many contributions to the Uniformed Services University of the Health Sciences (USUHS) over the past 30 years, her accomplishments reach far beyond the walls of USUHS. Her legacy belongs to the field of Malignant Hyperthermia (MH) research, and establishing the USUHS Department of Anesthesiology's MH Testing Center as one of the world's most recognized centers of excellence. The acronyms USUHS and MH have become synonymous to anesthesiologists world-wide due to Dr. Muldoon's tireless efforts. In the military world, Dr. Muldoon is known as "the MH Lady", and there is not a person who has studied anesthesiology who does not know her or know of her. I graduated from USUHS in 1993, and returned as faculty in 2004. While I initially had no intention of dedicating my academic career to MH, it was Dr. Muldoon's passion for the subject that attracted me. Her enthusiasm and burning desire to go to work every day, at an age when most people have long retired, was infectious for me. She made me want to pursue MH research with the same vigor. I cannot begin to thank her enough for the mentorship she has provided to me over the past six years. As a result, my reputation among my anesthesiology colleagues is that of an MH expert. Through Dr. Muldoon's efforts, my reputation will continue to grow as a nationally and internationally recognized MH authority. My greatest honor will be when people call me "the MH Guy". Dr. Muldoon treats the USUHS MH Program like it is her child, and I am dedicated to seeing her child grow and flourish. Albert Szent-Gyorgyi, the 1937 recipient of the Nobel Prize for Medicine, once wrote, "Research is to see what everybody else has seen, and to think what nobody else has thought." Dr. Muldoon embodies this message. She constantly encourages me to think outside of the box and push the envelope of our understanding. She has been an incredible inspiration to me, and I am driven to continue her legacy. I realize that the academic criteria for awarding the Carol J. Johns Medal involves more than)ust personal anecdotes of what Dr. Muldoon has done to advance the careers of junior faculty, but it is the personal attention that she provides to all of her colleagues and patients that sets her apart. I am just one phYSician in a long line of physicians whose career Sheila has nurtured. Take what I have written and amplify it laO-fold. If I can provide any further support for Sheila's nomination, please do not hesitate to ask. Sincerely, . '- John Capacchione, M.D. Associate Director, MH Testing Center, USUHS UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 IMACOLOGV TEACHING HOSPI 21 October 2010 WALTER REED ARMY MEOICAL CE NAVAL HOSPITAL. BETH To the Carol Johns Medal Committee, MALCOLM GROW AIR FORCE MEDICAL CE WILFORD HALL AIR FORCE MEDICAL CE Re: Nomination of Sheila M. Muldoon M.D. I am very pleased to have the opportunity to write a letter in support of the nomination of Dr. Sheila Muldoon for the Carol Johns Medal. Dr. Muldoon has been an outstanding servant of the Uniformed Services University (USU) for more than thirty years. She was already an established member of the faculty of the Department of Anesthesiology when I joined the University in 1981. Over the years since then I have had many opportunities to interact with her, and my admiration for her knowledge, insight and enthusiasm continues to increase. From 1984 until 2001 Dr. Muldoon served in the role of Chairperson for the Department of Anesthesiology; my perception is that the department flourished under her leadership. I will focus my comments here on her research activities and her contributions across departments in medical student teaching, since I am most familiar with these aspects of her work at USU. Dr. Muldoon started her research career while still at the Mayo Clinic, where she published several papers from a long-standing collaboration with Paul Vanhoutte, an international leader in research in cardiovascular pharmacology (and a recent President of the International Union of Pharmacology). When she moved to USU she brought an active, innovative research program with her, and proceeded to make her laboratory one of the recognized leaders in studies of the effects of anesthetics on vascular function. During this period, she also established an internationally recognized translational research program on malignant hyperthermia, a potentially lethal condition that may be induced in genetically pre-disposed individuals by exposure to anesthetic agents. This is an area in which she has made significant research contributions as well as providing a unique clinical service. Dr. Muldoon is now recognized internationally as a leading authority on malignant hyperthermia, receiving mUltiple invitations to participate in international conferences on this topic. She has used these research endeavors to provide very valuable research training to a long series of anesthesiology residents, post-doctoral fellows, and research assistants. She has also collaborated with faculty from other departments at USU, as reflected in the many papers co-authored with USU faculty members in her impressive list of publications. COincident with these research activities, Dr. Muldoon has also played an important role in medical education at USU. I can speak with most authority with respect to her support for the medical pharmacology course. Prior to my arrival at USU she was already working with the founding chair of the pharmacology department, Dr. Lewis Aronow, in the development of collaborative teaching on anesthetics from a 1 pharmacologic perspective. She presented lectures on the topic in the medical pharmacology course. and later passed this tradition on to her colleagues in the anesthesiology department, an arrangement that continues to this day. Under her leadership and in conjunction with pharmacology department faculty. a very effective coordination of basic science and clinical insights into the actions and uses of anesthetic agents was presented to medical students within the context of the pharmacology course, significantly predating other more recent efforts to enhance the integration of clinical teaching into the preclinical curriculum. Dr. Muldoon is also very supportive of her faculty colleagues. She has frequently sought the advice of pharmacology department faculty in the review of applicants for faculty positions in her department, has worked with us to facilitate the recruitment of highly qualified individuals, and has encouraged research collaborations between both civilian and military faculty in anesthesiology with faculty in other departments. She strongly supports the interests of faculty members of her department in their interactions with the administration at USU. In summary. Dr. Muldoon has played a major role in the academic life of Uniformed Services University for many years. She more than meets the criteria for recognition with the Carol Johns Medal.; she has worked diligently to enhance the welfare of faculty. she has made major contributions to medical education, and her research program has received international recognition that has enhanced the reputation of the University. I strongly support her nomination for the Cartol Johns Medal. Sincerely. Brian M. Cox. Ph.D. Professor and former Chairman Department of Pharmacology 2 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. Edward Hebert School of Medicine Department of Military and Emergency Medicine flO. HP-ALTH ANn 4301 Jones Bridge Road MII,ITARY PlI'.ltflORMA.NCP. Bethesda, MD 20814 PHONE: 301-295-3020 FAX: 301-295-6773 25 October 2010 Dear Dr. Artino: I am delighted to write to you in support of the nomination of Dr. Sheila Muldoon for the Carol J. Johns Medal. I can think of no one more deserving than Dr. Muldoon, who has served the USU and greater military communities for over 30 years. During each of those years she worked tirelessly to further the welfare and excellence of the USU faculty; to develop and promote outstanding educational programs in Anesthesiology for the students; and advance the reputation of the University locally, nationally, and internationally in here research and service in the area of Malignant Hyperthermia. She alone put USU on the map in this arena and has led the way for national and international collaborations. I believe I am both qualified and intimately familiar with the work and dedication of Dr. Muldoon, as I was her postdoctoral fellow from 1982 through 1884. She continued to be my mentor for many years, and that relationship has been maintained and grown over the years. We continue to collaborate, write papers, discuss research questions and I have personally experienced and witnessed her commitment to students, faculty, staff, and the pursuit of scholarly ideals. Her integrity is impeccable and she is not afraid of asking difficult questions; she always strives for the scientific truths. As a mentor she is dedicated, caring, and available: I saw her nurture every resident who came through the department, as evidenced by the Chairs of Anesthesiology since she stepped down - she both trained and mentored them all. Her mentees have been successful and appreciated her willingness and dedication to support their growth. Most published papers because she both led and inspired them. Dr. Muldoon continues to show intellectual curiosity, innovation, determination and compassion towards others. Dr. Muldoon is both a pioneer and leader in her field - her depth and breadth of knowledge are shared with colleagues, mentees and others who are interested. Dr. Muldoon has spent her career investigating a topic of importance to the military and the fruits of her efforts are respected by all. She is both a national and international leader, but as a faculty member and former department chair, she never lost sight of teaching service and research. If further information is required, please feel free to contact me by email [email protected]. Sincerely yours, Patricia Deuster, PhD, MPH Professor Department of Military and Emergency Medicine Department of Pharmacology and Physiology • RocftESTEI f MEDICAL CENTER Dr. Anthony Artino October 19,2010 Secretary-Treasurer of the USU Faculty Senate Uniformed Services University Bethesda, MD 20814 Re: Letter of Reference for Dr. Sheila Muldoon Dear Dr. Artino: It is with great pleasure that I write this strong letter of support for Dr. Sheila Muldoon, whom is being considered for the prestigious Carol J. Johns Medal, the highest career award bestowed upon Uniformed Services University faculty. To set the stage, I have interacted regularly with Dr. Muldoon over the past five years. Specifically, Dr. Muldoon and I are members of the Professional AdVisory Council (PAC) of the Malignant Hyperthermia Association of the United States (MHAUS) and we also both serve on the Advisory Council for the North American Malignant Hyperthermia Registry (NAMHR). In addition, Dr. Muldoon and I are Co-Investigators on a mUlti-institutional NIH funded Program Project Grant that involves preclinical and clinical investigations on the molecular basis of malignant hyperthermia. Our collaboration during the course of the PPG has resulted in our joining forces to further current understanding on MH genetics and pathogenesis and has already led to three abstracts and one original research manuscript that soon will be submitted for publication. Based on these many interactions, I believe that I am in an excellent position to comment on the impact of Dr. Muldoon's research and professional activities on the advancement of the local, national, and international reputation of the Uniformed Services University. Let me begin this letter expressing my deep conviction that Dr. Muldoon is a uniquely gifted and accomplished translational scientist, who possesses everything that an academic institution holds dear in its Clinician-Researcher faculty. After reviewing Dr. Muldoon's Curriculum Vitae, extensive list of research publications, as well as funding and service record you will no doubt be extremely impressed with the level of productivity and international acclaim that this outstanding investigator has achieved over the course of her illustrious career. In this letter, I hope to provide additional tangible evidence regarding Dr. Muldoon's unique compliment of scientific reputation, ingenuity/creativity, strong leadership qualities, and relentless drive/commitment to elucidate the genetic basis, epidemiology, and pathophysiology of malignant hyperthermia (MH), as well as improve MH diagnosis, treatment, and preparedness. Throughout her more than 3D-year career, Dr. Muldoon's research program has been a world-leader in forging new advances in the pathogenesis, diagnosis, treatment and prevention of MH and heat-related illnesses in humans. Direct evidence of this substantial body of work is readily apparent from her prolific publication record over the years, which includes over 100 original research publications, invited reviews and book chapters, as well as an additional -100 abstracts. Her publications appear in leading international journals in the field including Anesthesiology, Anesthesia and Analgesia, British Journal of )1 Elmwood Avenue' Box 711 . Rochester, NY 14642-8711 {/ice: 585-275-4824' t Although I have not had an opportunity to directly observe Dr. Muldoon's teaching, I have attended many of her scientific presentations and invited lectures at local, national and international meetings. Each of these seminars/lectures were not only interesting and topical, but were also well-organized and clearly presented. Her style is one of engaging her audience in a discussion and analysis of the relevant information, rather than to simply deliver a lecture on the material. Given her extensive organizational skills, attention to detail, and command of her field, I am confident that she must also be an effective, educator, and mentor. Dr. Muldoon has distinguished herself in providing outstanding academic and administrative leadership, as evidenced by her roles in the MHAUS and NAMHR, participation on numerous editorial boards and grant review committees, as well as earning a number of professional awards over the years. In summary, Dr. Muldoon is a truly remarkable and treasured jewel of your University. I view Sheila as a sort of twenty-first century renaissance scientist. She exhibits a rare combination of abilities that allows her to translate the solution of basic science problems to further the understanding, diagnosis, prevention, and treatment of MH and other heat-related disorders. At the same time, Dr. Muldoon is also an outstanding educator, mentor, and role model for future clinician scientists. Sheila exudes a seemingly unending wealth of energy, enthusiasm, and leadership to whatever she sets out to accomplish. Thus, I strongly and enthusiastically support Dr. Muldoon's consideration for the prestigious Carol J. Johns Medal; the growing legacy of this award will only be enhanced by forever being linked to this outstanding investigator. Please do not hesitate to contact me if you require any additional information. Sincerely, .~ . ...., Robert T. Dirksen, Ph. D. Professor of Pharmacology and Physiology University of Rochester Medical School l Elmwood Avenue· Box 711 . Rochester, NY 14642-8711 lee: 585-275-4824· Fax: 585-273-2652· [email protected] OJ. Anthony Artino, Secretary-Treasurer USU Faculty Senate October 17, 2010 Re: Career Award of the Carol J. Johns Medal Dr. Sheila Muldoon as candidate Dear Dr. Artino, Dr. Muldoon and I have interacted professionally since her arrival at the Mayo Clinic (then located only in Rochester) in the United States in 1966. She had finished her anesthesia education in Ireland and was now a fellow for a Master of Science Degree in Anesthesiology and Physiology, her mentor being Dr. Richard A. Theye, an internationally recognized anesthesia researcher. I was one of the three faculty in our then four neurosurgical operating rooms and neuroradiology. In fall, 1966, Dr. Muldoon spent several clinical months with us. Our daily schedule consistently included 2-3 craniotomies, one sitting position case, e.g., posterior fossa and cerebellar-pontine angle explorations, and various laminectomies. About every month or so, we used profound hypothermia for difficult to manage intra-cranial aneurysms. This involved surface hypothermia to 30-32° C, followed by pump bypass circulation to about 10 or 12° C. With circulation halted, surgery was eased by the bloodless field. With this concentration of material, Dr. Muldoon became skilled and knowledgeable in complex neuroanesthesia. During her research with Dr. Theye, she and I interacted again. We were both examining altered responses to muscle relaxants, hers on oxygen consumption, and mine on exaggerated succinylcholine-induced potassium fluxes in burns, muscle disuse, and denervation. We shared ideas, equipment, and enthusiasm for these projects. She earned her Master of Science Degree in 1969 and was appointed faculty as a Consultant in Anesthesiology. She branched out into research on isolated blood vessels in specialized apparatus tor maintaining tissues in vitro, and I began similar study of isolated skeletal muscle specimens, to investigate malignant hyperthermia (MH), an inherited metabolic response in humans and swine. We as usual exchanged knowledge and ideas, aided each other, and argued about where each of us was heading scientifically. This sharing continued to fall 1977, when she moved to USUHS. My laboratory was using some of her borrowed apparatus up to the day she packed everything for her departure. At Bethesda, she continued shared research with Mayo and USUHS, none with me. Several years later, our association began again in MH. I had continued my MH research and she now began it. About this time, the Malignant Hyperthermia Association of the United States (MHAUS) was organized to logically spread information on MH and coordinate research. She and I were both strongly involved in this and I began visits to USUHS. Her laboratory has become a major contributor to advances in MH and most recently in new non destructive methods for diagnosing inheritance ofMH. Her laboratory has shown, as have others, that lymphocytes respond much as do skeletal muscle biopsy specimens and can hopefully replace human muscle biopsies in diagnosing susceptibility. Further, she has been active in aiding patients in their search for organized advice, explanations, and specific care. MH susceptible patients must be given certain specific anesthetic agents to avoid triggering an episode ofMH. Dr. Muldoon has classical progress in her field and areas of interest, e.g., articles, conferences, presentations, meeting exhibits. She has been creative and provided feedback to others in aiding them. Through her research and her mentoring of others, in teaching, clinical care, and rese~ch, she has actively advanced her career at USUHS, and has developed and maintained professional relationships among colleagues within her areas of interest, both here and abroad. Her former residents are valued, whether in military or private practice. She is an active member of the European Malignant Hyperthermia Group, which coordinates the various countries as regards methods, organization, and approaches to patient care and testing. Laboratories in various countries that coordinate methodology can thus interpret and compare results with confidence. This has been a challenge, and these efforts parallel US approaches, with Dr. Muldoon actively contributing. Further, she has aided development in more isolated countries, e.g., Central and South America, and in Asia. Specifically, at USUHS, she was responsible for the advancement of anesthesia in a relatively new department, to gain equal status and influence with other universities. This furthers the advancement of her faculty and residents. She has been a major contributor to the educational programs, for anesthesia impacts at many levels: students, residents, fellows, and faculty. Her activities and goals have aided in establishing the reputation of her university, with continuing scientific publications, meetings, and associations among peers. Her publications reflect her , clinical involvement, her research into in vitro tissue responses, her work on intact animals, her MH research projects, and her involvement in addressing the problems inherent in caring for many patients with varying needs, whether MH or other disease entities. Her role in MHAUS has been outstanding, and she has been a board member for more that two decades. She has maintained balance between her personal life and her work, with the challenge of smoothly raising her daughter following the death of her husband. She is indeed a role model for family, colleagues, and students, and a mentor at every level. Dr. Muldoon's teaching and research represented formidable and successful challenges during the 19 year period in which she was at first acting chair (1984-] 987) and later official departmental chair. She also was Consultant to the Assistant Secretary of Defense for Health Affairs, in the Office of the Assistant Secretary of Defense Health Affairs in Washington. In 2001, she stepped down as Chair of her department, to continue as Professor. That did not alter her mentoring, clinical. or research commitments Sheila Muldoon has earned universal great respect and deserves full consideration in the selection of the Carol J. Johns Medal award. the Uniformed Services University's highest career award. It is my privilege to recommend her most highly . . Sincerely, Gerald A. Gronert, M.D. Professor emerilus Volunteer Faculty Department of Anesthesiology Department of Anesthesiology University of California, Davis University of New Mexico Albuquerque NM 538 Charniso Lane NW Albuquerque NM 87107 5058997051 [email protected] BCM October 19,2010 Baylor College of Medicine SUSAN L. HAMILTON, Ph.[ Professor and Chair Department of Molecular Physiology and Biophysics Dr. Anthony Artino L.F. McCollum Chair in Molecular P Secretary-Treasurer of the USU Faculty Senate One Baylor Plaza Uniformed Services University MS: BCM335 4301 Jones Bridge Road Houston. Texas 77030 Bethesda, Maryland 20814 713-798-5704 713-798-3475 Fax [email protected] Dear Dr. Artino, It gives me great pleasure to write a letter commenting on the amazing contributions of Dr. Sheila Muldoon. Sheila has almost single handedly raised awareness of malignant hyperthermia worldwide. She has made many of the key discoveries related to this disease and has greatly expanded our understanding of the molecular mechanisms involved in the disease process and laid the groundwork for new therapeutic interventions. She is also a very compassionate physician and a wonderful colleague. Recently Dr. Muldoon led the way to the discovery of the association of exertional rhabdomyolysis and malignant hyperthermia. Her approaches span treatment of patients to animal studies. Dr. Muldoon is probably the worlds' leading expert on malignant hyperthermia and with her amazing memory of MH research throughout the world she serves as a resource for all investigators in the field. Her leadership in the organization of meetings and interactions among investigators is without equal. She brings international recognition to Uniformed Services University of the Health Sciences and greatly deserves the recognition associated with the Carol J. Johns Medal. nc"reIY;) . ! M'c1)i ~~/j~j)1--- \.S an l. Hamilton, Ph.D. Professor and Chair L. F. McCollum Chair in Molecular Physiology \., --..:,.... Department 01 i'. Molecular Physiology I " and Biophysics UNIFORMED SERVICES UNIVERSITY OF THE HEAL TO SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 www.usuhs.mil 12 October 2010 Dear Dr. Anthony Artino, This letter is in support of Dr. Sheila Muldoon for the Carol J. Johns Medal. I have enjoyed being a colleague of Dr. Muldoon's in the F. Edward Hebert School of Medicine for over fourteen years. As a junior faculty member, I have benefitted from Dr. Muldoon's experience and encouragement. She has a strong academic background in anesthesiology, starting from her days as a young clinician and investigator at the Mayo Clinic before bringing her expertise to USUHS. Since my office is close to hers at USUHS, I have had the opportunity over the years to discuss research opportunities and interesting clinical problems. I have also been working on finishing my doctorate while working full-time. I have found Dr. Muldoon to be one of my strongest supporters for my studies. She has not only offered words of encouragement and advice, but has also allowed me use of some of her laboratory equipment and personnel for questions about laboratory procedures. She is also the main mentor for another student in my program in the Graduate School of Nursing who has always had wonderful things to say about Dr. Muldoon. Dr. Muldoon is a stickler for doing the science right, but I think that is one of the things that makes her stand out from others. If the science isn't solid then it isn't right. She is also a believer of pursuing your ideas, regardless of what your peers may sometimes think. As an example, she thought that genetics played an important part in malignant hyperthermia back in a time when the experts in her field thought that genetics would not help. Dr. Muldoon continued to pursue genetic links to malignant hyperthermia in her lab, which proved to be the right avenue to pursue. Genetics work on malignant hyperthermia and similar disorders continues here today at USUHS. Dr. Muldoon is a person who very much cares about her patients, and she tried hard to seek out the answers to some very difficult patient problems. She is well known as an expert in malignant hyperthennia. I periodically hear of physicians and patients who seek her out from all over for her expert insight on malignant hyperthennia and other anesthesia related disorders. I have found Dr. Muldoon to be a person who truly cares about people and doing the right thing. I will be saddened when Dr. Muldoon eventually retires. She supports a lot of good people with her program of research. Sincerely, ~C::Ut~ __ Ma~en N. Hood, MS, RN, FSMRT Assistant Professor of Radiology & Radiological Sciences Doctoral Candidate, Graduate School of Nursing Unifonned Services University of the Health Sciences Division of Anesthesiology and Pain Medicine Telephone (202) 476-2025 • Fax (202) 47 II i\\ichigan Arenue. N.W: ashington.IlC 20010-2970 Jctober 18, 2010 ~nthony Artino, PhD 3ecretary-Treasurer, Faculty Assembly Jniformed Services University of the Health Sciences ~301 Jones Bridge Road 3ethesda, MD 20814 )ear Dr. Artino: am honored to enthusiastically support Dr. Sheila Muldoon for the Uniformed Services University's lighest career award, the Carol J. Johns Medal. As I read the history and accomplishments of Dr. fohns I immediately think of Dr. Muldoon. Just as Dr. Johns achieved the highest honors in academic nedicine as a nationally recognized clinician, academician, and teacher so has Dr. Muldoon. As Dr. fohns furthered the welfare and excellence of the USU faculty; promoting outstanding educational )rograms for the students; and, advancing the reputation of the University locally, nationally, and nternationally so has Dr. Muldoon. I am particularly touched by Dr. Johns' personal humility and lentleness since this is exactly the qualities of Dr. Muldoon. have known Dr. Muldoon for over 20 years. Her commitment, devotion and passion to USUHS and nilitary personnel and families are evidenced by her 33 years of service to USUHS. Her extraordinary :>ng list of honors, committee and administrative service, editorial positions as well as clinical and esearch publications (100 articles, 14 chapters, 100 abstracts) span multiple areas including Iharmacology, clinical anesthesiology, genetiCS and malignant hyperthermia. Ay knowledge of Dr. Muldoon's mentoring and expertise come from my interactions with her in the leld of Malignant Hyperthermia. Dr. Muldoon is an internationally recognized authority in the field of Aalignant Hyperthermia. Dr. Muldoon is one of the main reasons why I developed expertise in the Irea of MH. She was a role model for me both in research and clinical endeavors. As a member of the Aalignant Hyperthermia Professional Advisory Committee and one of 30 Malignant Hotline ;onsultants for the United States I can personally attest that her actions have saved many military nd civilian lives which would have been lost to Malignant Hyperthermia reactions under anesthesia. )r. Muldoon's efforts have changed Malignant Hyperthermia from the "Anesthesiologist's Nightmare" ,ith an 80% mortality to a disease which is now understood, quickly recognized and effectively ·eated. Ir. Muldoon exemplifies all the attributes of Dr. Johns and deserves to be honored by this recognition. ,specttuIIY, T ~ . H iutf0t£{ /. f..~~ 'ichard F. Kaplan, MD lief, Division of Anesthesiology and Pain Medicine ww\\:ChildrensNational 3005 Susanne Court Owings Mills, MD 21117-1646 October 12,2010 Anthony Artino Ph.D. Secretary-Treasurer Uniformed Services University of the Health Sciences Senate Dear Dr. Artino, I write to enthusiastically support the nomination of Sheila M. Muldoont M.D., Professor of Anesthesiology, Uniformed Services University of the Health Sciences, for the Carol J. Johns Medal. Dr. Muldoon is a pre-eminent investigator in the field of malignant hyperthermia (MH), the only disorder triggered by anesthetics. She is a founding member of The North American Malignant Hyperthermia Registry and now serves as Chair of its Advisory Council. She is a key member of the Malignant Hyperthermia Association of the United States (MHAUS), a non-profit organization dedicated to serving the needs of MH susceptible families and their health care providers in the United States and elsewhere. Currently, she is the MHAUS Vice-President for Scientific Development. She has comprehensively evaluated the adverse anesthetic experiences of hundreds of military and civilian patients and has compassionately counseled those she has diagnosed as malignant hyperthermia susceptible. She is an international leader in understanding the underlying pathophysiology and molecular biology of this potentially lethal syndrome. Dr. Muldoon has generously fostered the investigative careers of multiple military and civilian MH researchers. I am proud to be one of those she has mentored for the past 23 years. She has been unstinting in her willingness to share with me: her strategies for managing individuals and administrative enterprises t her insights into scientific researcht and her expertise in bringing to publication joint scientific efforts. For the past 26 years t she has published important research articles (32) and chapters (12) in the MH field. She has been an authoritative and wise voice for advancing our understanding of malignant hyperthermia within the local, regional, national, and international communities. I believe that she has advanced the reputation of USUHS with her many unique and substantial contributions to the field of malignant hyperthermia. Sincerely yours, Marilyn Green Larach M.D. Originating Director (1987 - 1997) Senior Research Associate (1997 - present) The North American Malignant Hyperthermia Registry Member (1988 - present) Professional Advisory Council Malignant Hyperthermia Association of the United States UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 October 24,2010 Carol Johns Medal Committee USUHS Bethesda, MD Sheila Muldoon, M.D. Dear Carol Johns Medal Committee, It is my great privilege and honor to write this letter in support of Sheila Muldoon, M.D. as a candidate for the Carol Johns Medal. She is a renowned international leader in the field of anesthesiology and has done seminal work elucidating many aspects of malignant hyperthermia. Sheila is also an exceptional educator and mentor. She is selfless to a fault. Without a doubt, she is one of our university's finest all around faculty members and academic leaders. I consider her one of my more influential bosses. Critically, she was my first USUHS boss. It is in this capacity that I will speak to. What can I say to share with you the gratitude I have for this extraordinary woman? I can say that her approach to mentoring young faculty and encouraging students and residents is one that I have patterned my own approach to stewardship by. Sheila motivates, she encourages, she directs but most of all she believes in people. I first met Sheila in 1995, when she was the Chair of Anesthesiology at USUHS. She was incredibly busy then leading a USUHS clinical department, actively practicing anesthesiology in the operating rooms of Walter Reed and running the country's most active malignant hyperthermia labs. In contrast, I was a neurologist, fresh out of a civilian neuro critical care fellowship and was joining the USUHS faculty. No one knew what to do with me. Neurology had no space and critical care medicine had a billet but no USUHS presence. I was given the CCM billet but had nowhere to "hang my hat." So, who should take this itinerant Army major? Sheila Muldoon! This soon became an unlikely teacher-student relationship as it was a world renowned anesthesiologist and an unknown neurologist. I will wager that no such relationship existed anywhere else. However, she believed in me and believed in what I was trying to do --- create a critical care medicine presence at USUHS. In her mind, critical care medicine and anesthesiology are siblings and, of course, she is right. Through her vision and confidence in me, she allowed me to join her department and gave me some of her precious space. Furthermore, she underwrote my lab, provided me with equipment and hired my first lab assistant. Then as now, it is obvious how incredibly generous this is. Printed on (i) Recycled Peper From this beginning, I was able to embark on a wonderful career at USUHS in the military. Throughout my time here, Sheila has remained a stalwart mentor and friend. My first academic rank, assistant professor, was from Sheila and then, later, neurology. My second academic rank, associate professor, was from Sheila and then, later, neurology. It was she who recommended that I serve as Interim Chair of Neurology back in 2004. It was she who helped me get more space as my research efforts expanded. Through it all, Sheila was my champion. Ultimately, I returned to my roots of neurology but even then, Sheila allowed me to remain an active member of her department and to maintain the office space she lent me temporarily for over 10 years! By being a member of her department, I watched how she cultivated the careers of other young physician-scientists like Paul Mongan, Cynthia Shields and others. It was always selfless, with true kindness and a belief in each of us. Is there such a thing as altruism? I sometimes question that but only sometimes because eventually I remember Sheila. Through all this support, she never expected (let alone demand) authorships, co-PI status or anything of any kind in return. She asked for nothing other than for each of us to excel. This is a remarkable teacher, a remarkable faculty member and a truly remarkable human being. Deep in my heart, I believe Sheila Muldoon deserves the Carol Johns Medal more than anyone else in the university as she epitomizes what is great and good in such a distinction. For me, she will always be a truly special person, one who believed in me and sponsored me when I was an unknown and needed a champion most of all. I hope that I conveyed that Dr. Sheila Muldoon is a grand faculty member in the noblest sense. If each of us strives to make the future brighter, then we must begin by teaching the children. But we must encourage, motivate, inspire and "believe in" them as Sheila Muldoon still does. Thank you for allowing me to share these thoughts with you. If I can be of any additional assistance, please do not hesitate to call me at 301-295-3643 or [email protected]. Very respectfully, College of Medicine PO Box 100321 Graduate Medical Education Gainesville, FL 32610-0321 352-265-0152 352-265-8966-fax October 19, 2010 Anthony Artino, PhD Secretary-Treasurer, Faculty Senate Uniformed Services University of the Health Sciences 4201 Jones Bridge Road Bethesda,~ 20814 Dear Dr. Artino: I am writing this letter in support of the nomination of Sheila M. Muldoon, ~, currently a Professor of Anesthesiology at your institution, for the Carol Johns medal. I have known Sheila since 1979 in many capaci first as a resident physician in Anesthesiology (4 years), next as a faculty member in Anesthesiology at USUH under her mentorship (5 years), and finally as a colleague and friend of many years. Candidates for this award must exhibit the characteristics of Dr. Johns in order to be considered. These characteristics include: 1. furthering the welfare and excellence of the USU faculty; 2. promoting outstanding educational programs for the students; and 3. advancing the reputation of the University locally, nationally, and internationally. I would like to address each of these characteristics which Sheila possesses in abundance. First, mentoring fa is really what Sheila is all about. I have very distinct memories of Dr. Muldoon having long talks with me ab importance of academic pursuits. As a young faculty member, I was very focused on developing my clinical in neurolOgic monitoring and neurosurgical anesthesia and providing the best possible clinical care to my pa1 at Walter Reed. I found myself neglecting academic purSuits - much to Sheila's chagrin. She admonished IDI if I wanted to be successful in the academic arena, I would need to be involved in research and education to a greater degree than I was. Next, she showed me how I might do this, and as a great mentor, she recognized, she would be successful and where she would meet resistance. She correctly recognized that I loved to teach. with one of my colleagues Jerry Burger (National Naval Medical Center), I redesigned and implemented a ne curriculum for medical students in anesthesiology. With her guidance, the clerkship in anesthesiology becal extremely popular and quickly evolved beyond just specialty topics. Skills essential for all military physiciar such as airway management, principles of resuscitation, line placement, and many others - became part and of what was taught by her Department. Although I left the military in 1988 to join the faculty at the University of Florida, Sheila's influence never left and continues to this day. Although her great love of basic science research never really attracted me, her gu directing my efforts toward educational pursuits persists to this day and enabled me to be promoted to full Professor here at the University of Florida. I really credit my success in becoming first the residency progral The Foundation for The Gator Nation An Equal Opportunity Institution director in Anesthesiology and now the Dean for Graduate Medical Education to her mentoring skills and continually directing part of my attention to the academic side of my career. Beyond me, Sheila has mentored many other successful academic faculty including Jerry Burger (mentioned earlier), Paul Mongan, and others. These faculty were successful both in the military arena and subsequently civilian academic practice. Even a cursory review of her CV reveals many basic scientists who got their start 1 Dr. Muldoon's superb guidance. Many have said that an academic physician's success can best be measured accomplishments of those she or he has mentored over the years. If that is true, then Sheila has earned the hi~ possible degree of success. Sheila always recognized the importance of educational programs and devoted high priority to development new and innovative programs for students both at the core clerkship and residency levels. When I first begar working with her, the clerkship was a very typical clerkship in anesthesiology. Sheila correctly recognized th vast majority of students would not be entering the profession of Anesthesiology and encouraged Jerry Burge I to develop a curriculum that would have value for all medical students. As a result, the curriculum refocusE what every physician needs to know about what will happen to patients undergoing anesthesia and surgery. example, the family physician needs to know what happens when one of their arthritic, elderly patients with , history of hypertension and congestive heart failure undergoes a total hip arthroplasty. These concepts were well taught anywhere in the curriculum, and Dr. Muldoon correctly recognized the importance of teaching perioperative medicine. The curriculum then evolved further to focus on those skills best taught by anesthesiologists who use them every day that every military physician who could be deployed would need t know. In summary, Sheila knew at the most fundamental level that without the best possible education prog other academic missions such as research cannot flourish - and mentored her faculty accordingly. Finally, Sheila's work with the extremely serious and still often fatal disease, malignant hyperthermia, is recol throughout the world as fundamental to the diagnosis, treatment, and the ultimate understanding of the pathophysiology of this disease. Even to this day, she is recognized as the highest level expert with respect to disease. To give perspective about her accomplishments, I need to spend a moment discussing this disease. Malignant Hyperthermia (MH) is a disease that strikes patients, most commonly without any warning, durinl surgery requiring anesthesia. Through interactions with certain anesthetic triggering agents (the majority of ( we use have the potential to trigger the disease in susceptible individuals), the body's metabolism loses its regulatory mechanisms resulting in massive increases in oxygen consumption, C02 production, and heat production. Without treatment, the disease progresses to uncontrolled hyperthermia (body temperature >42 degrees Celsius) and death from widespread protein denaturation. While this disease is fortunately rare, whE occurs, the clinician must promptly recognize the disease and institute appropriate therapy or death will certc: result. The disease is uncommon enough that many clinicians will never see it. I really cannot adequately summarize Sheila's contributions in this letter. Suffice it to say that her work and her superb collaborative ne' across the country resulted in: 1. A reliable treatment for the disease if recognized early enough 2. Establishment of an association (Malignant Hyperthermia Association of the United States) which 24/ provides clinical assistance to anesthesiologists allover the world who need help with the diagnosis, treatment of this syndrome. 3. Understanding that this disease is, in fact, inherited and isolation of the genetic defect that induces M susceptibility 4. Worldwide education program including simulator scenarios that enable clinicians to experience the 1 and symptoms of this syndrome in a simulated situation and learn how to recognize and promptly in: appropriate treatment. The Uniformed Service University of the Health Sciences is one of those few institutions recognized as a soure education, understanding, and help with this terrible and often fatal syndrome. Dr. Muldoon's expertise in basic research relatively early on resulted in service for many years in the NIH Stu Sections related to her areas of expertise. There is really no greater compliment and respect that can be given clinician scientist than to be appointed to an NIH Study Section charged with prioritizing and awarding fundi new research projects. Such an appointment acknowledges the scientific and clinical expertise of the individu appointed as well as his/her ability to recognize important new research and researchers. Finally, her mentorship of countless graduate students and physicians has further spread the knowledge that USUHS can and does produce some of the finest scientists and clinicians in all fields of medicine. She is, in m view, one of the most widely recognized clinician researchers in the specialty of Anesthesiology. In summary, Sheila has my absolute highest endorsement of this award. Sheila exemplifies Dr. Johns' every characteristic and is most deserving of this recognition of her career devoted to academic medicine. She is, in view, the best of the best. Whether or not she is chosen for this award, I am personally grateful to her for all h mentoring. Her gentle and sensitive direction has, without doubt, been one of the most important factors lea, my current success in academic medicine. Sincerely yours, ~,~,.~M{) Michael E. Mahla, MD Professor of Anesthesiology and Neurosurgery Associate Chair for Clinical Affairs Assistant Dean for Graduate Medical Education E-mail: mahla®ufi.edu Mobile / Pager: 352-494-6782 Dr. Anthony Artino Secretary-Treasurer of the USU Faculty Senate I am writing this letter in support of the nomination of Sheila Muldoon MD for the Carol J Johns Medal. I first met Dr. Muldoon when I was Director of the Cold Stress Division of the Hyperbaric Medicine Program Center (HMPC) at the Naval Medical Research Institute in Bethesda from 1979 to 1982. At the time Dr. Muldoon provided invaluable support to our studies on cold stress in divers by helping us with the catecholamine assays which were integral to our evaluations of stress in these human subjects. The results were published in a peer reviewed journal and proved extremely useful to the operational capabilities of both the United States Navy, as well as the Royal Navy. The cooperation between Dr. Muldoon's laboratory and HMPC on subsequent human subject studies was extremely valuable, providing HMPC with much needed expertise in our overall goal of delineating cold stress in divers. My next major Interaction with Dr. Muldoon came when I was at the Anesthesiology Department at the National Naval Medical Center (NNMC). Dr. Muldoon's close cooperation with the NNMC Anesthesiology Department provided an avenue for the Anesthesiology Staff and residents to have exposure to University Level Research under the auspices of one who made sure that the quality of endeavor was second to none. This venture between the Academic Anesthesiology Department at USUHS and the Anesthesiology Training Program at NNMC was most definitely of great value to the residency program at NNMC. Numerous residents and staff members were involved in research projects contributing greatly to the overall quality ofthe residency training program. Another major benefit to the residency training program was the establishment of the simulation center which at the time was relatively unique but which is now considered essential to any decent training program. Dr. Muldoon had a pivotal role in providing this asset to our training program as well. One of the most important contributions of Dr. Muldoon to the Anesthesiology Training program at NNMC came when the Department of Defense mandated that a multi-service residency training program be established at Bethesda. At the time I was Chair of the Anesthesiology Department at NNMC and was given the task of getting the integrated training program organized and, most importantly, accredited by the ABMS. There were many obstacles to getting this done not least of which was the requirement at the time that the program director had to be the same person as the Department Chair. As can be expected, there was no way one person could be considered Chair of the Anesthesiology Department at all three service hospitals in the National capital Consortium area. Fortunately for us, Dr. Muldoon had sufficient "clout" within the Anesthesia Program Director community that we were able to convince the ABMS that integrating the training programs at NNMCC, Walter Reed, Malcom Grow AND the USUHS Anesthesiology Department was a viable proposition. Our National Capital Consortium Anesthesia Residency Program was the first integrated program to receive ABMS approval nationwide. I strongly believe that Dr. Sheila Muldoon has made outstanding contributions to all three of the major areas of consideration for the Carol J. Johns Medal and that she would be a most worthy recipient of this honor. She has my highest possible recommendation for this honor. Alvin R. Manalaysa Ph.D., M.D. Captain, United States Navy, (ret) 1012112010 To whom it may concern, I am pleased to write this letter in support of Dr. Sheila Muldoon's nomination for the USU Carol 10hns Medal. I was a faculty member in the Dept. of Anesthesiology, USU, from 1999 -2005. During that time, I worked closely with Dr. Muldoon on a research project whose objective it was to develop a cell based assay for the diagnosis of Malignant Hyperthermia (MH). When I came to USU, Dr. Muldoon was already known nationally and internationally for her leadership in the diagnosis and treatment ofMH. But Dr. Muldoon is a clinician who is not content with the status quo in medicine. Diagnosis of MH involves an invasive muscle biopsy that is expensive and burdensome to undergo, especially for pediatric patients. Dr. Muldoon made it her professional goal to develop alternative, non-invasive diagnostic methods for MH that would enable screening of much larger numbers of at-risk patients for this potentially fatal disorder. Dr. Muldoon energetically tackled difficult areas of new science, including genetic screening and cellular regulation of calcium. She reached out to first-tier researchers across the country, and made USU a ~entral point of coordination for scientists involved in unraveling the molecular basis of MH and for ::linicians who were trying to understand the complex phenotype of this disease. There were two things that 1 enjoyed most about working with Dr. Muldoon. First was her insatiable curiosity and openness to learning new ideas and new techniques. Few people can say that they are as energetic and driven at the end of their careers as they are at the beginning, but I believe that Dr. Muldoon is one. Second, Dr. Muldoon to me exemplified the best of what a clinician can and should be. She is absolutely dedicated to her patients a,nd spent countless hours on the phone with them and their families, explaining and helping. Over the years she deVeloped an invaluable understanding of the clinical subtleties ofMH, and did her best to communicate those to other physicians as well as basic researchers. Dr. Muldoon also worked tirelessly to support the faculty in the Dept of Anesthesiology. Her door was always open for discussion, and her computer was always turned on if you needed help with a grant rewrite. She made efforts to create a network of contacts for new faculty, held departmental journal clubs, and facilitated navigating the USU bureaucracy. She was always bursting with new ideas, and aimed for true collaboration between the clinical and basic scientists in the department. She handled her many administrative responsibilities with dedication and grace and shared many keen insights about university governance. She worked hard to maximize the impact that USU could have on improving military medicine, both in teaching and practice. I cannot end this letter without one small comment about Dr. Muldoon's Irish wit, which was often in evidence. I once sat, dumbstruck, as Dr. Muldoon regaled a small group of us with what must have been an encyclopedia's worth of knowledge about Irish history. After that, it was clear to me why the English have never been able to subjugate that island! With best wishes for Dr. Muldoon's continued success at USU and beyond, Leslie McKinney, PhD Pharmacologist Center for Drug Evaluation and Research Food and Drug Administration University of Colorado Denver Department of Anes1hesiology October 21, 2010 Mail Stop 8113 12401 East 17th Avenue Aurora, CO 80045 Dear Dr Artino, Office: 720-848-6709 Fax: 720-848-7375 It is my distinct pleasure to write a letter of support of the nomination of Sheila Muldoon, MD, for the Carol J. Johns Medal. I cannot think of any person more deserving of this award. I have known Dr Muldoon since 1985 when, as a medical student at USUHS, I was assigned to Anesthesiology at Walter Reed Army Medical Center. As a student advocate she had a profound influence on my decision to enter into the specialty of Anesthesiology. She has continued to have a positive influence throughout my career. With her continued support, guidance, and wisdom I have achieved enormous success in positions of leadership, education and scholarship. However, I am not the only one. One of the measures of greatness of a department is the development of highly successful faculty. Others that went before and after me have also been supported and mentored to great success. I am in good company with others in uniform that have gone on to be Department, Hospital and Specialty Leaders and those retired that are Scientists, Professors, Department Chairs and Deans. In addition to mentoring successful faculty, Dr Muldoon has supported the growth and development of education programs for the medical students and anesthesiology residents. While most ofUSU is concerned with medical student education, Dr Muldoon had the vision and drive to improve on the continuum of education by advocating for an integrated, highly functioning, clinically and academically oriented Department of Anesthesiology. Functionally, this education vision was accomplished by having the administrative and leadership of the Anesthesiology Residency Program at USU and the clinical faculty working at the hospitals at least 3 days/week. In addition she advocated for education . advancement. High fidelity mannequin based simulation for medical training was developed and advocated by the Anesthesiology Community in the 1990's. In the mid 1990's Dr Muldoon recognized the importance of this new education paradigm. She insured that the Department of Anesthesiology had the resources and key personnel to succeed. As a result, simulation within the Anesthesiology Department is well regarded by students and residents and recognized as a national leader in ongoing development within the field of medical simulation. As an academic anesthesiologist I can attest to the national and international reputation of Dr Muldoon. Without exception, the mere mention of the Uniformed Services University within a Department of Anesthesiology in North America, Europe and Australia will elicit a comment on the great work Dr Muldoon has done over her career in the field of Malignant Hyperthermia. She is a recognized international expert in the clinical management and expansion of knowledge in that field. In summary, Dr. Muldoon has an outstanding record in furthering the welfare and excellence of the USU faculty, promoting outstanding educational programs for the students, and advancing the reputation of the University locally, nationally, and internationally. She leads by example. Her leadership is rare because she insured that those to whom she was charged were empowered to excel in education, leadership and scholarship. Her contributions live on in the career of those she helped along the way. I recommend her without reservation. r~,---l- Paul D Mongan MD Professor, Department of Anesthesiology University of Colorado at Denver Downtown Campus Anschutz Medical Campus Denver, Colorado Aurora, Colorado UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 Anthony Artino, PhD 19 October 2010 Secretary-Treasurer, Faculty Senate Uniformed Services University of the Health Sciences 4201 Jones Bridge Road Bethesda, MD 20814 Dear Anthony, I am tremendously pleased and honored to write this strong letter in support of recognizing Dr. Shelia Muldoon with the award of the Carol Johns Medal. Dr. Muldoon is a founding member of this fine university and her sustained record of academic excellence and contribution to USUHS makes her an absolutely superb candidate for this high honor. Dr. Muldoon's many accomplishments in the realms of clinical science and administration are well documented by the facts presented in her curriculum vitae. The particular insights I feel especially compelled to speak to here, however, are her roles as a colleague, role model and friend. I first met Shelia in 1978 when we both joined the faculty of the fledgling USUHS. As happens with so many other people who have met Shelia, we quickly became close colleagues and friends. These ties provided the basis for very open communication through which we shared many experiences as faculty members of a dynamic and evolving School of Medicine. Among the first qualities I came to appreciate in Shelia is her fundamental and enthusiastic commitment to biological science. It was almost immediately clear from our first discussions that Shelia loves science and is dedicated to its pursuit. Discussing experiments with her was enlivening and just pure fun. Her enthusiasm for her own bench work was contagious and her willingness to invest her time and energy to help me and others sort out our scientific challenges was always encouraging and overall, represented an important contribution to our developing department. Overtime, Shelia and I even developed a collaborative research project from which a joint publication documents one outcome of our interdisciplinary efforts. Others have shared this same experience working with Shelia. Her fine qualities of interest, enthusiasm and commitment remain hallmarks of Dr. Shelia's professional presence here at USUHS. Another feature of Shelia's professionalism which I have always admired is her steadfast commitment to her clinical discipline and her sustained efforts to ensure that her department served its University and the DOD in the very best way possible. Shelia was the strong and visionary advocate that was needed for established the USUHS Department of Anesthesiology. She developed her department with a keen eye towards its essential roles in clinical teaching, research and university administration. Her balanced representation insured that the department secured the fundamental needs to Printed on @ Recycled Paper thrive while sustaining a steady flow of contributions back to the university and DOD. Dr. Muldoon has always taken particular pride and joy in her work as a mentor. I fondly recall our many conversations about her fellows and the important role of the USUHS anesthesiology training program. Her professionalism and effectiveness as Chair, Department of Anesthesiology, established her as a role model in the USUHS academic community. For all of these reasons I am pleased to offer my strongest recommendation for the award for the Carol Johns Medal to Dr. Shelia Muldoon. For more the three decades Shelia has been an absolutely stellar member of the USUHS faculty. She is truly a worthy recipient for this fine award. Sincerely, Gregory P. Mueller. Ph.D. Professor and Vice Chair Department of Anatomy, Physiology, and Genetics Program in Neuroscience October 7, 2010 Dr. Thomas E. Nelson, PhD Professor Emeritus Department Anesthesiology Wake Forest University Medical School Winston-Salem, NC To Whom It May Concern: I am strongly supporting Dr. Sheila Muldoon's nomination for the Carol J. Johns Medal at the Uniformed Services University. I have known Dr. Muldoon for over 30 years and during that time I have observed her academic and clinical services toward advancing the pharmacogenetic disease malignant hyperthermia. Dr. Muldoon has been active in many aspects of malignant hyperthermia and consequently she has brought national and international attention to her laboratory, her department and to the University. She currently sits on the Board of Directors of the Malignant Hyperthermia Association and has played critical roles in establishment and maintenance of the National Malignant Hyperthermia Registry. Her laboratory has maintained a critical skeletal muscle contracture testing center and is now one of a few remaining in this country to which patients can be referred for testing. Genetic testing for malignant hyperthermia is in the developmental stages and Dr. Muldoon's laboratory is the only one in the USA with an active malignant hyperthermia genetics effort from which several significant publications have occurred. Recently, Dr. Muldoon and her colleagues have published significant findings regarding the linkage of rhabdomyolysis among armed services trainees and mutations in the ryanodine receptor (calcium channel) gene; implicating a possible association with malignant hyperthermia susceptibility. While I have had very little exposure to Dr. Muldoon's activities at the Uniformed Services University, I have no doubt that the same dedication that she has shown toward malignant hyperthermia must have occurred over the years within her department and across the University. If you need to contact me for further information I can be reached at my home. 336 -945-9499. My best regards, Tom Nelson October 25, 2010 To Whom It May Concern: I am writing in support of Dr. Sheila Muldoon for the Uniformed Services University (USUHS) Carol Johns Medal. I became acquainted with Dr. Muldoon through her support of the Graduate School of Nursing in her capacity as a guest lecturer to our Graduate Nursing Students in their pathophysiology and Advanced Principles of Anesthesia courses. The insight and expertise contributed by Dr. Muldoon in her lectures to our students is invaluable. She is always wiling to assist in our courses and students consistently rate her as a prepared and expert lecturer. In May of 2009 I began my own studies in the PhD of Nursing Program at USUHS. My interest was to study the role of catecholamines in the triggering of Malignant Hyperthermia. I approached Dr. Muldoon to act as a committee chair and my primary mentor on Malignant Hyperthermia. I cannot begin to explain how welcoming and facilitating Dr. Muldoon has been in this role. As a nursing student in a graduate student role, I was not sure what to expect from what is undoubtedly one of the worlds most recognized experts in Malignant Hyperthermia. Dr. Muldoon makes herself available almost 24 hours a day for my many questions and continuously challenges me to dig deeper, while providing me with great wings to explore my own journey to become a research scientist. I could have no better role model. It is with deepest conviction that I nominate Dr. Muldoon for this award. She is a tremendous and unparalleled asset to this community of scientist and scholars. Respectfully, Lt. Colonel Susan M. Perry, CRNA, Lt. Col, USAF, NC Assistant Professor, Graduate School of Nursing, Director of Clinical Education, Nurse Anesthesia Program Uniformed Services University, Bethesda, Maryland 301-295-1118 0/21/2010 15:14 2173421230 EFF SURGERV CENTER PAGE 01/~ 904 West Temple I Effingh THE EFFINGHAM AMBULATORY Surgery Center exceptional people· eJeceptlonal care Anthony Artino, PhD Secretary-Treasurer Faculty Senate Unifonned Services University oithe Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814 Re: Cafol J. Johns Medal It is my great honor and privilege to recommend Sheila M. Muldoon, M.D. for this award. I was fortunate to work with Dr Muldoon for ten years during my time in the Anesthesia Department at Bethesda Naval Hospital. Sheila was such a strong mentor for all the area's military Anesthesiologists (Walter Reed, Bethesda and of course, our Air Force colleagues from Andrews). During my residency, I was fortunate to spend six m.onths in Dr Muldoon's labs. Besid~ learning to perform valuable anesthesia research, I was also able to assist Sheila with h~:incredible work in Malignant Hyperthennia. Because of her guidance and mentormg,":.1·applied and completed ~~~~:.. ~ong Walter Reed Army Institute of Research's MedicarR~search Fellowship~~~~a~ this experience, J not only was involved in conthiued work with Dr.Mid~@~ helped guide the Human Use Committee at Bethesda Navil HOspital for a ~'~f.yeaTs. None of this would have been possible without Sheilaf s.sage;S1:lidance #.~~~~tI~ in the right direction .',"'"r.c·· ':j ..•. ,...... : ... '.. ::: ~ _ :: ':;L:~'~;:~' _.,··~'-r-':i:·;:i;:'::·'i:'1:iq::::;;:: :;.) Dr Muldoon is world renowned fot her work ~ Mali~tliYJerth~'1B~liH'iJj~~~~:H.:::~~:;~:}::::·,:~·l::: is, in m humble 0 inion, tbe world leader for :~ii~IDti~i::; ·'.-'·'·Ll':~';~;:~~:'l·~~~~fmil;t;tj;ii~:'t~:::: Y P .:: " ': :~;, L; "", ._~ .. ,,:';~':Lf.~ ",.:r" ::"':'t.~"i~~:~~~'t~":':1t '~'" /' . . the only reliable test for MH. Her work in this fi~ld:hiSib~~i@~'· .... _:;t~titf\~~'.l~~r:·,.:·· . USUHS. MH projects are never contemplated:wftti~1*.:·~~~g~~~~1iil~~~~·~::~:;'·:···' expertise. Her lifelong commitment and dedi~atiw.t();;tbiStco~l.~~~~:&'unting. Her expertise in this area is unparalleled She.,li~,p~:ti~jki\~i~~~!fo'·an .', • I " • " __ ...... ,. ' •• 1'1 .~. 1 ''1~ J1 ~ ~ incredible number of military and civilian cO'neagu~,.)VhCY~V:e!'~U;efttly become recognj:,ed expertS in this field. .-.. : .. ····;::···':··::···~:.':·:<·:i\·~:,.. ;,::·~:·· - • .' :'.", • I~ .: ,':' ::" ;: 'i";:~' ~.:;: .~.. , :;";:1.'-- I do not have enough words in me to .d~s¢rl}j~~,~;~~~~~~uldoon bas been in my life. My time spent in her dep~~iit·tj$QHS:~:~i.lva1uable and rewarding. Her mentorship gu,Mi~:~;~I1e(j~ .Bit iriY~.J:tjil~. ·~e~Y:iti~ endeavors. No one is m~oredeservt4ing~~~i'i~<;';: ...•. ·;<;:j:~Xi ,rr.: 1- •• ,I t IJ·.!, •... '·11 :':)1"'" -,'1. • •• t •• ,'" ' Robert H p~~;~tib-: ~;:I ,.~~~~v.:'" ~'. . .".,: ...... ,':, .. CDR Me USN (~et)··:;<:·:·:(··:>· .1 .: .... ",:1 :,1' UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 www.usuhs.mll October 19,2010 LCDR Anthony Artino Secretary-Treasurer, Faculty Senate Uniformed Services University ofthe Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814 Dear LCDR Artino, It is my great pleasure to write you regarding the nomination of our friend and colleague, Sheila Muldoon, M.D., for the Uniformed Services University of tile Health Sciences Carol Johns Award. In many ways, which I shall enumerate, Dr. Muldoon embodies the concept underpinning the Carol Johns Award itself, and I believe that extending this award to Dr. Muldoon will provide the University with an outstanding model of the kind of person who ought to be so recognized. The heart of a University is the quality of its faculty. and Dr. Muldoon is simply outstanding. Beginning her career in medicine at the very best University in Ireland, landing in the United States at Mayo Clinic, and then coming to USUHS in 1977, very early in the life of the University, and then rapidly escalating to become Chair of the then nascent Department of Anesthesiology, it was clear to all that she was smart, skilled in her craft, politically astute, and able to guide younger colleagues into the upper realms of her field. As Chair, Dr. Muldoon made her Department both academic and service oriented. My own experience early in my tenure at USU was the realization that something very special could be created by combining resources and creating the first center for patient simulation. It was all done on a handshake, something that 1 mention here to indicate the integrity which Dr. Muldoon has brought to every venture I am aware of here at the University. And the entire enterprise has survived and prospered since. Finally, Dr. Muldoon has brought great repute to the University by her many activities, both in service to the University and to the Department of Defense. It is no surprise to those who know Dr. Muldoon well that when she recently stepped down as Chair of Anesthesiology, she simultaneously won part of a large Program Project Grant from the NIH on her favorite topic, malignant hypothermia. I conclude by urging the Committee to award Dr. Muldoon this well deserved award. Sincerel,/) Harvey'. JOllard, M. Professor and Chair Department of Anatomy, Physiology and Genetics CAPT, USPHS (ret.) Learning to Care/or Those in Harm :\' Way 'he William W. Backus Hospital October 20, 2010 Anthony Artino, PhD Secretary-Treasurer, Faculty Senate Uniformed Services University of the Health Sciences 4201 Jones Bridge Road Bethesda, MD 20814 Dear Doctor Artino, I am pleased to have the opportunity to write in support of Dr. Sheila Muldoon as the recipient of the Carol J. Johns Medal presented by the USUHS Faulty Senate. I have known Dr. Muldoon since 1982 and was privileged to be a student, resident, attending, staff and faculty member influenced by her enthusiastic commitment to the science and clinical practice of Anesthesiology. Sheila Muldoon demonstrates the qualities of the consummate medical faculty member. She has always been committed, above all else, to the education of medical students. Her passion for anesthesiology and understanding the basic science of many aspects of anesthesia formed a groundwork: for her interaction with students - which involved high expectations in critical thinking and performance in a collegial and supportive manner. She recognized the importance of making the Third- and F ourth-Year Anesthesia' Clerkships a way to engage studen~s not only as future prospects for anesthesia training and residency, but also to help them develop as caring physicians, regardless of their ultimate specialty choice. Dr. Muldoon generously devoted time and talent to the training of residents and junior attendings as well, trying to engage them in research and educational endeavors - often at the expense of leaving her lab to participate in clinical activities, where she excelled at correlating the basic science of our specialty with its clinical practice. She was selfless in her promotion and development of anyone who had an interest in anesthesia and would frequently go to extraordinary lengths to help individuals cross specialty boundaries to approach questions in unique ways. Sheila is an international subject expert in several areas of anesthesia research, most notably that of malignant hyperthermia. She has played a key role in the elucidation of the mechanisms of action/detection of this often lethal disease, and is a much cited and well-known resource and authority in this area, keeping USUHS in the forefront. Dr. Muldoon has devoted her career to the USUHS community, is genuinely dedicated to faculty development, and has made great efforts to promote her department and the university among national and international academic and clinical activities. Sheila truly embodies the spirit of this very special award: like Carol Johns, she too, is a "wann and gifted woman with remarkable personal humility" and has been a friend. teacher and mentor to many men and women who have passed through USUHS. I am sure that she is a most deserving recipient and I would encourage the selection committee to recognize her many contributions to the education of physicians, nurses, and scientists and to the development of our university by awarding her the Carol J. Johns Medal. Sincerely, "- T~en Pudimat, MD., CHCQM USUHS Class of 1986 Chief, Department of Anesthesiology Medical Director, Perioperative Services Office: 860-823-6395 [email protected] October 19. : Dr. Anthony Artino oan! of Directors Secretary-Treasurer (aroll. \f[) Uniformed Services University \1 Duel"h. \IS. RN. lS·P Faculty Senate (,eurt;. ~IS. nit 430 I Jones Bridge Road \Itrrlll. CR .... A. \1S" \llc"liu; Bethesda, M 0 20814 .\luldolln. \\D ,aJl<,huno. hq RE: CAROL J. JOHNS MEDAL > ITeen L.lrach. \11) l\~ hJ!lI(j Slate l 'nl\enlt)' The Malignant Hyperthermia Association (?f the U. S. (MHAUS) is the only patient adV( letart h). CR'iA. PhD organization dedicated to improvement of patient care and advancement of research into M~ .\Iuldoon. MD ormed Sen i('1."\ ll1lwrslt~ MH-like syndromes. Dr. Muldoon has been a Board member for more than two decades an " liealth S<:icnce' for Scientific Affairs. She has provided expert guidance to the organization such that MHAI "enocrg. \1[l ( p~ the leading organization worldwide for education and guidance for professionals and patiel I !larnaha, .\ledll',,1 ( enlel s"sskr. .\11l managing MH. ,eT";II\ \)1 I llui\\I11c ) Strt'll' As the founding Chair of the Department of Anesthesiology at USUHS, she created a high ql et' \\omcn'~ HO'qlll.11 Center .1eJIC,tl (It'netll'S educational and research program and the development of scores of excellent practitiom r., In \If) anesthesiology. Her department was one of the first to employ manikin-based simulatio 'l·P.Il~ uf Ba>;t'1. S\\ltlerland training medical students and residents. Such simulation is rapidly becoming a core componc ,glrl.,. liDS. Phil ,t'r\ll~ 01 California . medical education. .Ing'''' Executhe Director PO Box 1061)· II East State Street· Sherhurne, NY 13460· 607-674-7lJOI • Fa.' 607-674-71)10 [)j •.mnr \1. Ihuglll'rl) www.mhaus.org • intola mhaus.org "Tilt' missio/l oj' MHA US i.1 /0 promote ()ptimllm Cilrt' (/1/(/ .1('iellTijic //Ill/en/willing 0/ MH (lnd related Thanks to her efforts, the Department of Anesthesiology has obtained national and international reputation as attested by the large output of peer-reviewed articles, awarding of NIH grants, and presentations at national and international committees. The Department of Anesthesiology at USUHS is, in my mind, the only Anesthesiology Department in the U. S. that is advancing laboratory and clinical understanding ofMH. Other individuals may be involved in such research, but the Department at USUHS is the only one with a comprehensive program involving laboratory, animal and human studies. As the award is to be made to an individual who has: I. Furthered the welfare and excellence of the USU faculty 2. Promoted outstanding educational programs for USU students including medical clerkships, residencies and fellowships and 3. Advanced the reputation ofthe University locally, nationally, and internationally. Clearly, Dr. Muldoon meets all of these criteria. It has been my pleasure to collaborate with Dr. Muldoon for these many years. I have learned to respect and depend on her astute insights in biology and organizational dynamics in furthering my own contributions to understanding MH as well as to carrying out my functions as Board Member and President of the Malignant Hyperthermia Association of the United States. Very truly yours, Henry Rosenberg, MD President, MHAUS Director, Department of Medical Education and Clinical Research Saint Barnabas Medical Center Livingston, NJ 07039 Adjunct Professor of Anesthesiology Columbia University College of Physicians and Surgeons UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 Anesthesiology 301-295-3140 (OFFICE) 301-295-2200 (FAX) October 20, 2010 Dear Dr. Anthony Artino, I enthusiastically write this letter in the support of Dr. Sheila Muldoon for the Uniformed Services University's Carol Johns Medal. I have known Dr. Muldoon for more than 10 years and was first introduced to her when I was performing genetic analysis on a large American family with Malignant Hyperthermia. At that time the genetic study of Malignant Hyperthermia was in infancy and I was immediately impressed with Dr. Muldoon's enthusiasm, knowledge and vision she had for studying this disease. Her passion and expertise motivated me and in the fall of 2006 I joined the Department of Anesthesiology as an assistant professor. Whenever I had a question or problem, Dr. Muldoon was the first person I came to for advice. Her support, experience and encouragement were invaluable to me and for my research as a junior faculty member of this school. Dr. Muldoon is a well known expert in Malignant Hyperthermia, a sudden metabolic reaction to certain anesthetics. She devoted her clinical practice and research career to better understand this potentially fatal disease in order to treat and protect her patients. She has established a Malignant Hyperthermia Diagnostic Center at the Department of Anesthesiology that continues to serve and consult countless number of patients and their family members. This center has become a nationally and internationally recognized research facility for Malignant Hyperthermia due to Dr. Muldoon's leadership. Dr. Muldoon is a passionate clinician, great mentor and tireless leader. It is uncommon especially for me as a researcher to find a doctor who remembers all of her patients and continues to consult them for years. I vividly remember two of her patients UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA. MARYLAND 20814-4799 Anesthesiology 301-295-3140 (OFFICE) 301-295-2200 (FAX) with a highly unusual presentation of the disease. During our discussion I discovered that Dr. Muldoon was working with these families for more than a decade and was trying to find scientific explanation behind their unique disease expression. Eventually, we found that these patients had double genetic variants instead of the usual one and the presence of double variants was a potential cause of the unusual disease presentation. This was one of many great examples that I have witnessed Dr. Muldoon's dedication, persistence and scientific intuition, which is a direct reflection of her commitment to improving the quality of life for her patients and increasing our knowledge on this devastating disease. I felt so fortunate to witness such a devotion to a very difficult patient problem that was resolved due to Dr. Muldoon's scientific questioning and translation of research findings to help a patient's everyday need. Dr. Muldoon is an excellent leader and mentor to students, young members of the scientific community. Her passion for research and expertise has inspired me and will inspire others, which makes her a great candidate for the prestigious Carol Johns Medal. Sincerely, Nyamkhishig Sambuughin, Ph.D Assistant Professor DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service National Institutes of Health Bethesda, Maryland 20892 Anthony Artino, PhD Secretary-Treasurer, Faculty Senate Uniformed Services University of the Health Sciences 4201 Jones Bridge Road, Bethesda, MD 20814 Dear Dr. Artino, 19 October 2010 I am very much excited to learn that Dr. Sheila Muldoon was nominated for the Carol J. Johns Medal Award. I sincerely and faithfully believe that she deserves the Medal. I joined Sheila's Department in 1996 and worked with her till 2004 for 8 years and witnessed her enormous contributions to the public health, especially through her continuous efforts on progressing malignant hyperthermia (MH) research. As it is apparent from publicly available database, Sheila is one of the most well known MH investigators (in both basic and clinical research) nationally and internationally. Her activities and leadership for the Malignant Hyperthermia Association of the United States (MHAUS) and North American MH Registry etc certainly advanced the reputation of the USUHS locally, nationally and internationally. What I should note in this letter should be about behind the story of her success. Despite her great reputations, progressing the MH research program was not an easy task at all. We had struggled tremendously to sustain the research program perhaps because MH is recognized simply as a rare disease. Needless to say, we had spent enormous time in grant writing and producing data without enough support. What I think a treasure to me is that I was with her and could watch her incredible passion on pursuing one goal, which was to move the research forward no matter what. When we talk about her work, there is no complexity. Just simply, go, go and go and then go. A rumor is that she will retire next spring. I don't believe that will happen. This is my sincere hope that the Carol J. Johns Medal Award will go to Dr. Sheila Muldoon who really deserves. Please feel free to ask me anything if you have any question or request regarding this preparation. Sincerely, Sei, M.D.,Ph. Gastroenterology Section, National Institute of Diabetes, Digestive & Kidney Diseases 10 Center Drive, Bldg 10, Rrn 9C - t t 2 MSC 1804, Bethesda, MD 20892-1385 Tel: 301-594-3550, Fax: 301-402-0600 D OF DIRECTORS Denham S. Ward, MD, PhD FOUNDATION FOR ANESTHESIA erSlty of Rochester EDUCATION AND RESEARCH rlAIR. James R. Zaidan. MD, MBA I UnIVersity School of Medicine 200 First Street SW, WF6-674 • Rochester, MN 55905 A Faculty In 1977, Dr. Muldoon left the prestigious Mayo Clinic to come to the new and untested Uniformed Services University of the Health Sciences. Since her arrival at USU, Dr. Muldoon has maintained a steadfast commitment to military anesthesiology. Dr. Muldoon's depaI1ment is the first exposure to academic anesthesiology for all medical students. She has mentored countless medical students giving them their first experience in basic and clinical research. She consistently recruited young high-quality military aI1esthesiologist faculty to serve as role models for military medical students. She provided a solid grounding in clinical and basic science research to all of her junior faculty. She has graciously served as a sounding board to the three department chairs who followed, after she stepped down as chairman of the Department of Anesthesiology. For the past nine years Dr. Muldoon has worked part-time, but has continued to put in full-time effort in mentoringjunior faculty members and helping in the University strive for academic excellence. For two generations of military anesthesiologist, the quintessential example of an academic anesthesiologist is Dr. Sheila Muldoon. Education Dr. Muldoon instituted an anesthesiology rotation as a core part of all third-year clerk ships ensuring that every medical student had a basic understanding ofthe implications of sedation anesthesia and surgery on their patients. This core anesthesiology program was unique among United States medical schools. In 1997 Dr. Muldoon (along with Dr. Pollard) had the vision to see the utility of High Fidelity Human Simulation in medical education. A decade ahead of the rest of the country, she provided highly coveted resources, space and personnel, to develop USU's first simulation laboratory (The Patient Simulation Laboratory, PSL). Since its inception the PSL has provided hands on realistic medical educational experiences to medical students in a114 years, nursing students and to multiple residency programs. The type of simulation based educational programs pioneered under Dr. Muldoon's leadership are now considered central curricular elements for medical training worldwide. University Reputation Dr. Muldoon's authorship of greater than 90 peer-reviewed articles, greater than 90 published abstracts and 14 invited book chapters are testament to her highly successful and productive research career. Her early work focused on eliciting anesthetic agent's impact on the sympathetic nervous system. This information is now part of the core of our understanding of the modem anesthetic. More recently Dr. Muldoon has focused her research efforts on Malignant Hyperthermia (MH), a genetically inherited muscle disorder that can be triggered by anesthetic medications. Dr. Muldoon it is an internationally recognized expert in MH. She is invited to speak at MH conferences all over the globe. Dr. Muldoon is the director of one of only 4 MH clinical testing centers in the United States. This center is responsible for all DOD related clinical consultations. She has been on the Board of Directors of the Malignant Hyperthermia Association of the United States ( MHAUS) since 1996 and is the director of the North American Malignant Hyperthermia Registry. The registry serves as a central repository ofMH data for researchers and clinicians. Twelve book chapters and more than 30 articles on MH as well as her NIH funded grant are a testament to her expertise, and her research productivity in this area. She and her co-investigators have made great strides in understanding the genetics of MH. They are now developing insight into the relationship between MH and exertional heat injury, a topic of specific military relevance. She was also recognized for her academic excellence and expertise in MH with the MHAUS special recognition award in 2006. Sheila M. Muldoon MD has dedicated more than 30 years to faculty development, student education and research at USU. She has made long lasting significant contributions to the University and is a recognized world expert in her chosen research field. I can think of no better way to honor her achievements and commitment to the University and Military Anesthesiology than by awarding her the Carol Johns Medal. Cynthia H. Shields MD COL MC USA (Ret) Acting Chair Dept of Anesthesiology 2006-2010 Associate Professor Uniformed Services University MAYO CLINIC Jacksonville, 20 October, 2010 To The Faculty Senate Uniformed Services University of the Health Sciences 4301 Jones Bridge Road, Bethesda, MD 20814-4712 To Whom It May Concern: It is my honor to write a letter of support for Professor Sheila Muldoon for the award of the Carol J Johns Medal. I have come to know Professor Muldoon in 2002, when she hired me to the department of anesthesiology at USUHS. As an anesthesiologist, I had heard about her reputation as an expert in malignant hyperthermia during my residency and her name was found on many articles and chapters coming out ofUSUHS on that important life threatening topic. Once at USUHS, I quickly became involved as the associate medical director in the malignant hyperthermia program at USUHS, which Professor Muldoon developed. This is the only such program for the uniformed services and one of only 5 centers in North America. Under her guidance, the program at USUHS has gained national and international recognition, diagnosing and treating a rare, but life threatening disorder for many military members as well as civilians. At a point in her career where others might think about retirement, Professor Muldoon took a sabbatical to spend some time in Europe to learn about a new way of testing for this disorder. She brought back the knowledge and tools to start a new era of malignant hyperthermia testing. Under her guidance genetic testing for MH was introduced and many ofthe early publications came from this University, making it the forerunner of genetic testing for this disease. Her vision of developing a less invasive test, which could be shipped to a testing site (rather than the patient having to travel to a testing center) changed the way most malignant hyperthermia testing is now done here in America. Professor Muldoon is a true expert in malignant hyperthermia and her advice is thought after by her peers nationally and internationally, which is reflected in the many national and international lectures she has been invited to, advancing the reputation of the Uniformed Services University. In addition to her accomplishments in the field of malignant hyperthermia, Professor Muldoon has been an outstanding mentor for me and many other current and former faculty members of USUHS, who are now practicing in many well respected institutions throughout the country. Without her mentorship and guidance in my research activities, my academic career would probably have ended right after my residency. Professor Muldoon was supportive of my interests in hyperbaric medicine and mentored and supported my research collaboration with the Navy Medical Research Center in Bethesda on perfluorocarbons in the treatment of decompression sickness. Even though she had little experience in the field of hyperbaric medicine, her experience in grant writing, IRB procedures and in conducting research proved to be of great help and from which I still benefit in my current career. Under her chairmanship, the simulation center of the department of anesthesiology at USUHS was developed, which has an outstanding national and international reputation and has served countless students and physicians of the armed forces saving lives across the nation and across the globe. As an assistant professor of that department at USUHS, I was involved in teaching of the medical students and anesthesia residents and have first hand knowledge how this training has improved medical knowledge and behavior in crisis situations of the students. I still draw from this experience in my current capacity as the associate medical director of the simulation training center at the Mayo Clinic in Florida. In addition to her accomplished career in anesthesiology, with well over 200 publications, book chapters, abstracts and invited publications she is still a nice, warm and gentle person, with the personal humility that makes it a pleasure to be around her. Unfortunately, I have never known Carol Johns, but from the description of her, I see a lot of resemblance in Sheila Muldoon. Professor Muldoon's name will always be associated with the Uniformed Services University of the Health Sciences, who has supported her to advance the science of medicine, educate students and residents and to diagnose and heal the sick. I can only support her nomination to receive this prestigious award. Sincerely Klaus Torp MD Assistant Professor of Anesthesiology, Uniformed Services University of the Health Sciences Assistant Professor of Anesthesiology, Mayo Graduate School of Medicine Associate Medical Director of the Simulation Training Center, Mayo Clinic, Florida Peri-operative Medical Director Mayo Clinic Florida 4500 San Pablo Rd Jacksonville, FL 32224 Ph.: 904956-3328 Fax: 904 956-3332 Tab 17 President's Report • Dean Hinshaw's honors • Appointment of Dr. Sculley as Interim Executive Dean of the Postgraduate Dental College • Leadership offsite • Update on Fort Hood review • Periodic senior leadership reviews: Vice President for Finance and Administration • Update on Secretary Gates' efficiency efforts • Discussions with the National Library of Medicine regarding an educational program in health informatics February 2011 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES SOUTHERN REGIONAL OFFICE 7800 IH·10 West, Suite 220 San Antonio, TX 78230 http://www.usuhs.mll January 18, 2011 MEMORANDUM FOR BOARD OF REGENTS (BOR) SUBJECT: Army Postgraduate Dental School (APGDS) 1. The Army Dental Corps Chief has made the decision to seek affiliation with the USU Postgraduate Dental College (PGDC) to obtain the Master's of Science in Oral Biology degree for its Comprehensive Dentistry residents. 2. The Army is in the process of producing its documentation for review by the BOR and Middle States Commission on Higher Education. This documentation will be forwarded to Middle States as soon as developed and will be available along with faculty appointment packets for the May 2011 BOR meeting. 3. The APGDS will consist of the APGDS Dean's office at Ft Sam Houston in San Antonio and additional education sites at Ft Bragg, Ft Hood, and Schofield Barracks, Hawaii. Each of the programs will be similarly accredited and focused on producing well rounded comprehensive dentists who are academically qualified for the master's degree and board certification through the American Board of General Dentistry. However, there are minor variances in the programs which will be reflected in the documentation. The differences are due to levels of support and collocated additional residency programs. There are collocated Oral and Maxillofacial Surgery Residencies at Ft Bragg and Hawaii and an Endodontic residency at Ft Bragg. The Comprehensive Dentistry Program stands alone at Ft Hood. The Hawaii program will benefit from a well developed Clinical Investigation Activity at the Tripier Army Medical Center to support research projects. The other programs will receive research support as needed from the Tri-service Center for Oral health Studies (TSCOHS). Each program has a well qualified group of mentors who can provide additional individual support to the residents' research efforts. ~ Patrick D. Sculley, DDS, MA Major General (Retired) Interim Executive Dean Postgraduate Dental College Learning to Care Jor 7hose in Harm's Ufzy