www.med-associates.com Newsletter of the Zurn and Herrera Family Companies: Med Associates, Catamount R&D, Mansfield R&D, Razel Scientific Instruments, and Living Systems Instruments

issue 9 || spring 2009

new products Wheel Analysis Software (SOF-861) Our new software for circadian rhythm analysis contents: 7 using our wireless running wheels.

from the founder what’s new 2 Med Associates founder, 4 Med Associates announces Karl Zurn, addresses how exciting collaboration with Noldus; our companies are situated Summer Short Courses in Neuro- in the current economy. science schedule announced.

product who we are 8 particulars 11 Meet Valerie Gadouas, Learn about our line of accurate our shipping administrator. and dependable Razel syringe pumps.

recent citations 12 Check out some of the publications we’ve recently added to our citations database. issue 9 || spring 2009

from the founder

In this newsletter I will diverge from the history of the behavioral companies and comment a bit on our companies with respect to the current economy. I believe the Zurn and Herrera family companies are in good shape to deal with these eco- nomic conditions. During the last several years we’ve taken prudent steps to build our businesses, specifically on capital equipment and facilities, pursuing engineering and design to offer the largest array of behavioral test equipment available from any manufacturer, and incorporating basic research as part of the foundation of our product development process.

Small businesses like ours are the least expensive job engines of our economy, and are a tremendous asset to the American economy. Companies of this size typically reinvest the majority of earnings back into the company, allowing our businesses and employee base to grow. While we are concerned that the proposed tax structure will limit business owners’ ability to reinvest, we remain optimistic that the current administration will support the companies that remain at the heart of our country and economy. We are very encouraged by the focus on education in the approved stimulus package, and particularly the timely appropriations to NIH. We estimate that for every $150,000 in new equipment orders we receive we will be able to create one new job. MedLines, the newsletter of Med Associates Inc., In the past decade we have invested considerable amounts of money on quality keeps you informed of our manufacturing equipment to keep our companies competitive. These include state- latest news and events. It is designed to be primarily of-the art automated computer-controlled milling centers, saws, lathes, routers, read online at www.med- electrical circuit board assembly (pick and place) and more. We are continuously associates.com/medlines pursuing new product development, product enhancements, and ventures into new by navigating through the areas. By building this level of infrastructure, we are able to produce a majority of various sections. Alterna- tively, this print version is our products in-house, thus maintaining control over our manufacturing process available. while providing jobs to our local economy.

2 || MedLines || spring 2009 from the founder [cont’d]

We are very encouraged by the focus on education in the approved stimulus package, and particularly the timely appropriations to NIH. We estimate that for every $150,000 in new equipment orders we receive we will be able to Basic research is part of the foundation of our create one new job. product development process. Our St. Albans, Vermont Science Center is home to our in-house test laboratories. At present we have started the process of adding about 5,000 square feet to our 23,000 square feet of laboratories, which already include a vivarium with survival surgical capabilities. More details on our facility upgrades are included in our new behavioral catalog, available from the Sales department.

Recently we have been expanding our businesses by acquiring and/or developing agreements with other companies. We purchased Living Systems Instrumentation, a Burlington, Vermont-based company that offers instruments for perfused, cannulated blood vessels. In addition, we have entered into a cooperative agreement with Noldus. More information on these ventures is included in the What’s New section.

Our company focus has always been about how to best serve our customers. Inter- nal research, state-of-the-art production facilities, and personal investment of time and funds have been directed towards this goal. It’s been many years since Med Associates was run by myself and my wife Jane. Now MED has three manufacturing/ research sites and more than 90 employees. But the dedication to customers that was present back then is still alive and well today.

Sincerely,

Karl R. Zurn, M.E.E

www.med-associates.com || 3 what’s new

Med Associates and Noldus Announce Collaboration

Med Associates and Noldus signed into effect an agreement that allows Med Associates to offer Noldus Ethovision XT software as a video tracking solution with our mazes and arenas. In addition, Noldus will offer Med Associates mazes and arenas in conjunction with Ethovision XT software. Med Asso- ciates will be able to provide technical support to our customers, and this combination of Med Associates mazes and arenas with Noldus Ethovision XT software will be available worldwide from Med Associates, Noldus, or our respective representatives.

The management team at Med Associates reflected on this recent agreement. “Med Associates is looking forward to a strong relationship with Noldus. Med Associates is a recognized leader in animal test equipment, such as mazes, arenas, and other behavioral test apparatuses. Noldus is a recognized leader in tracking software. We feel the combination of Med Associates mazes and arenas with Noldus tracking software, such as Ethovision XT, represents a powerful solution for researchers desiring the best hardware and software available. Med Associates is pleased to offer Ethovision XT software as a video tracking solution in combination with our Elevated Plus Mazes, Zero Mazes, T-Mazes, Radial Arm Mazes, Barnes Mazes, Open Field Arenas and Home Cages, and Forced Swim Test, ” Karl Zurn, Founder of Med Associates and Chairman of the Board, Bridget Zurn, President of Med Associates, and Gerry Herrera, Ph.D., Vice President of Research and Development at Med Associates.

Lucas Noldus, Ph.D., Founder and President of Noldus Information Technology, commented “We are very pleased with this agreement with Med Associates, who are internationally recognized for their high-quality test equipment. Through our collaboration, we can now offer our worldwide customers integrated measurement and analysis solu- tions for behavioral neuroscience.”

Please contact Sales if you are interested in a Noldus Ethovision XT, Med Associates maze set-up. •

Zurn and Herrera Family Companies Med Associates Exhibits at EPA: Announce Program to Aid Researchers Eastern Psychological Association Obtaining Stimulus Funding

Pittsburgh, PA • March 6–8 On March 5, 2009, the Zurn and Herrera Family companies sent out a letter that supports the American Recovery This past March, Med Associates exhibited at the and Reinvestment Act of 2009 that is providing $8.2 Eastern Psychological Association annual meeting at billion to the National Institutes of Health for stimulating the Westin Hotel in Pittsburgh, PA. Thank you to the basic research. We have created special incentives for many people who stimulus grant funding that include matching contribu- stopped by our tions and complimentary installation services. Contact booth to discuss Sales to discuss how you may benefit from these offers. their current We will do our best to provide you with timely quotes experiments and and work with you to meet your grant application needs. equipment needs! • For more information, go to www.med-associates.com/ Stimulus/email.html. •

4 || MedLines || spring 2009 what’s new [cont’d]

Med Associates, Razel, and Living Systems to Exhibit at FASEB Stop by New Orleans, LA • April 18–22 our booths!330 326 Med Associates # Med Associates, Razel and Living Systems will exhibit at the Federation of American Living Systems328 # Societies for Experimental Biology annual meeting at the Ernest N. Morial Convention Razel # Center in New Orleans, Louisiana. Please visit our booths to check out the Med Associates updated product literature and mouse wireless running wheel. We will also have copies of the updated behavioral catalog available on CD for your convenience. Living Systems will be displaying the new dual channel self-heated vessel baths and Razel will have all pumps on display.

Please stop by our poster on Monday, April 20, 2009 during the poster session of 12:45-3:00pm for our latest research—Abstract Title: Y-27632 relaxation of carbachol-induced smooth muscle contraction in guinea pig trachea. You can locate the poster by—Abstract Number: 6760, Program Number: 781.2, Poster Board Number: D199. •

2000th MED-PC® License Issued in 2009 This year marks a significant milestone in the history of to develop their own procedures, we have many standard Med Associates Inc., and our Industry Standard MED-PC® procedures available in turn-key packages. We can also behavioral instrumentation control software. We are develop custom procedures according to your specifications. pleased to announce the issuance of the 2000th MED-PC® MED-PC® is the software of choice for most serious user license this year. behavioral science researchers. We maintain a compre- Although some manufacturers may try, it is difficult to hensive database of research articles published using compare any other system to MED-PC®. MED-PC® is MED-PC® software, and citations using MED-PC® the only commercially available software for behavioral generally out number any other commercially available experiment control that allows running of multiple, software. For example, a recent three year survey of simultaneous, concurrent schedules. This is due to the all research articles published in the Journal of Experi- structure of our state language, MedState Notation™, mental Analysis of Behavior (2006–2008) revealed that which was designed specifically for controlling behavioral of the 61 articles published on studies involving animal research instrumentation. Having stood the test of subjects, 38 of these articles utilized MED-PC® software time, MedState Notation™ continues to be the choice to control experiments and gather data. Only two articles of more laboratories than any other behavioral control mentioned other commercial software products. The language. It provides a precise documentation of be- remaining articles utilized custom or non-commercially havioral procedures, serving as a permanent record of available software, or did not use software in their the experimental protocol. MedState Notation™ uses experiments. simple commands whose function is inherently recog- MED-PC® software continues to undergo feature design nizable and easy to learn (e.g., ON, OFF, SHOW, ADD, and development. We are always looking for ways to IF, and SET). Placing these commands into logically make a good thing even better. Feel free to contact ordered text gives the user total flexibility over the Med Associates for more information, or to provide control of chamber components, stimuli, reward mech- comments or suggestions. • anisms, and data variables. For users who do not wish

www.med-associates.com || 5 what’s new [cont’d]

Short Courses in NEUROSCIENCE

Short Courses in Neuroscience Summer 2009 Schedule

Med Associates Short Courses in Neuroscience are an important part of our summer schedule at our Science Center R&D facility in St. Albans, Vermont. These workshops are great for the beginning user of our equipment, or for a refresher. Respected researchers in various fields of research teach the courses. Please see the dates and course descriptions below. Be sure to check our website for future updates on the courses, where you can fill out the registration form as well as scholarship forms for people at educational institutions. We expect to post registration materials in early May. Please contact us early, as the classes are kept small for maximum one-on-one attention.

Learning, Memory and Classical Fear Conditioning Running Basic MED-PC® Programs: June 24–26, 2009 An Introduction to MEDLAB 8 July 23, 2009 This three-day intensive workshop will cover theoretical This course is a free workshop geared to introduce the and technical aspects related to the study of conditioned novice MED-PC® user, or potential user, to running basic fear using the freeze response as a dependent measure. behavioral test protocols using our powerful and flexible In addition, spatial learning and memory will be covered MED-PC® Research Control and Data Acquisition software. using the water maze. Other modules will focus on place Software and equipment installation will be covered. conditioning, and assays for locomotor activity. Laboratory Med Associates’ staff will teach this course. exercises will be performed using an automated video motion analysis system, and this type of system will An Introduction to Behavioral Research Protocol be compared/contrasted to freeze scores obtained by Programming: Getting Started with MED-PC® human observation. Special attention will be paid to July 24, 2009 activity and shock reactivity, training, testing, extinction, Learn the basics of writing MedState Notation™ programs and context discrimination. Water maze studies will be to control your behavioral experiments. Instruction will conducted using automated video tracking systems. be provided by following the exercises in the MED-PC® Laboratory exercises for locomotor assays and place Programmer’s Guide. If you already have worked on conditioning will be conducted using standard systems your own MedState Notation™ programs, be prepared offered by Med Associates Inc. The course will be taught to bring examples of them, or bring the details of your by Dr. Stephan Anagnostaras from UCSD, a recognized behavioral experiments. This will allow you to practice authority in murine fear conditioning. using your own protocols and procedures. Med Associates’ staff will teach this course. •

6 || MedLines || spring 2009 new products

Wheel Analysis Software (SOF-861)

Med Associates is excited to offer new software to complement the recent release of our mouse wireless running wheels and wheel manager software. Wheel Analysis Software (SOF-861) provides the researcher with additional analysis tools to your wireless wheel data collection. This software is designed for circadian rhythm analysis and can be used off-line or in real time on data acquired with our wireless running wheels. Wheel Analysis Software generates actograms and periodograms. This software provides visualization of wheel running data, and also enables statistical analyses of biological rhythms. Contact Sales to receive a quote on this new software.

Product Updates Wheel Manager Software (SOF-860) Update Release: New Version (1.4.1) Med Associates has updated the Wheel Manager Software (SOF-860) used with the mouse wireless running wheels. This update includes many modifications that users have suggested.

Video Freeze Software (SOF-843) Update Release: New Version (2.5.1) Med Associates has upgraded the Video Freeze Software (SOF-843). Many of the modifications are direct suggestions from users of our Video Freeze system. Contact Sales for questions about how you can take advantage of this software update. •

www.med-associates.com || 7 product particulars

Razel Syringe Pumps

R azel syringe pumps have been available to researchers since 1968. During those 40

years the pumps have developed The R-E standalone syringe pump a reputation for affordability, reliability, and quality. In 2005 our company Mansfield Research and Development acquired Razel Scientific Instruments and continues to provide the scientific community with these accurate and dependable syringe pumps.

Infusion syringe pumps are widely used in many areas of research and industry. The Razel syringe pump line has been designed to cover a wide range of user needs. The pumps can operate manually, via computer, or on a timed infusion schedule. Syringe infusion rates of 0.00028 to 24 ml/min are possible depending on pump choice. All syringe pumps are designed to work with readily available syringes.

R-E TTL pulses or switch closure. In this way, the syringe The R-E syringe pump is outfitted with a single speed pump can be operated for set amounts of time via synchronous motor. With this setup, the speed of the MED-PC® or other research tools. Other options for motor determines the infusion rate for various syringes this pump include adapters to hold multiple syringes (5–50 ml capacity). Available motor speeds range from (R-ACC-Micro syringe adapter), and the R-DE option 0.008 rpm (0.017–0.603 ml/hr), to 20 rpm (0.688–24.122 that has two pumps mounted on one base offering ml/min). In its simplest form the R-E is a standalone dual site synchronous infusion or use of an adapter pump operated by pressing an on/off switch. The R-ES that allows for five, 50 or 10 ml syringes to be used option allows the user to operate the syringe pump via simultaneously (R-ACC-5, R-ACC-5/10ml respectively).

8 || MedLines || spring 2009 product particulars [cont’d]

R99-E on their computer, send on/off commands, set ramping Researchers who need a infusion schedules, and select exact dose volumes. This pump that allows multiple infusion speeds without changing pump is available with all options available for the R99 motors or syringe sizes should consider the R99 pump line. line, as well as remote operation using TTL or switch The R99 pumps have a built in wheel style flow chart that closure (R-Option-S). has 99 equally spaced pump speeds from 0.25 to 143 ml/hr when used with 5–50 ml syringes. A user simply selects the flow rate from the chart, inputs the corresponding number using a digital switch and begins infusing. Options are available for this syringe that allow the flow rate to be increased by 3 times (R99-EJ), or decreased to 1/10 of the Infusion Pump Control normal speed (R99-EM). The R99-EJM model covers this (IPC) Software for the R100 Syringe Pump entire infusion spectrum, providing rates from 0.025 to The IPC software allows users 430 ml/hr. The R99 pump line offers options for a single all the functionality of the API (R-ACC-Micro syringe insert) or multiple-micro syringe software with a few added benefits. IPC can control up to adapter (R-ACC-6), empty syringe alarms (R-Option-F), 24 syringe pumps, users can easily enter cross sectional and a reversal switch option allows the pump to withdraw areas for syringes not currently available in the syringe or infuse (R-Option-B). library, and complete infusion protocols can be created. Infusion protocols can include ramped schedules from 0.01 to 430 ml/hr depending on the syringe type used. Steps can be added to protocols for pauses, withdrawals, and infusions. Each step can be designated with an initial and final flow rate, duration, or injection volume. This software is very useful for researchers who need multiple injection R100-E durations or volumes in designated time periods, or those In its standard form who are managing many syringe pumps. the R100-E pump allows users to set infusion rates, via digital switches, based on —continued on next page syringe manufacturer and size. An internal computer controls the infusion rate, and a convenient LCD display shows the infusion rate and syringe type used. This allows the user to select exact infusion rates from 0.025 to 430 ml/hr. Researchers who select the R100-EC option are provided with a USB interface and API software that allows control of 16 pumps. The software allows users to select flow rates

www.med-associates.com || 9 product particulars [cont’d]

R-104A High/Low Speed Precision PHM-100VS Microliter Syringe Pump Variable Speed Syringe Pump Using high quality microliter glass syringes allows The PHM-100VS pump gives users the ability to this pump to ensure precise, accurate delivery vary the speed and duration of infusion using digital every time. This pump supports 10, 100, and 500 switches. Infusion times can range from 0.1 to 99 µl glass syringes. The pump has the ability to inject seconds in 0.1 second increments. The speed of the entire syringe volume in a single injection at injection is controlled by the unit’s stepper motor. unprecedented speeds. This system can empty a There are nine available motor speeds allowing 500 µl syringe in less than 400 ms. The pumps are for injections rates from 0.017 ml/min to 24.122 USB controlled for ease of use. ml/min. The pump is designed for syringes ranging from 1 ml to 50 ml. Users interested in the R99 pump line should also consider the PHM-100VS as it has a wider range of injection rates and allows injection duration to be pump controlled. •

PHM-102 Triple Infusion Pump If periodic infusions of animals in their home cages are of necessity for your research the PHM-102 should interest you. This pump allows researchers to provide timed infusions at equally spaced intervals for infusion of up to three animals concurrently. Just like the R-E pump, infusion speed and volume are determined by the single speed motor selected and syringe size used.

10 || MedLines || spring 2009 who we are

Meet Valerie Gadouas, Our Shipping Administrator

Valerie is our very personable shipping administrator A native of Vermont, Valerie was born and raised responsible for processing orders, invoicing, and in St. Albans and currently resides in Highgate. working with shipping carriers to obtain estimates She and her husband Al have two grown sons, and scheduling. You may have interacted with her Dan and Marc, who also live in the area, and two to register software to receive the password, or granddaughters. Valerie is family-focused and enjoys spoken with her to determine the status of your spending time with them at home or on Lake Cham- order. She is based in our Georgia, Vermont facility. plain, reading or fishing. Med Associates held its first annual Catfish Derby in 2008—Valerie won the Valerie is diligent in getting orders sent in a timely miscellaneous division with a 36-inch Bowfin fish manner and enjoys meeting customer needs. She weighing 8 pounds! • has worked at Med Associates for eight years, and spent her first two years in manufacturing and electrical assembly.

www.med-associates.com || 11 recent citations

Is your paper here? Check out some of the publications we’ve recently added to our citations database. These citations are added as we notice publications in the press, or when readers submit their published papers directly to us.

Our extensive listing of publications citing the use of Med Associates research instrumentation is updated regularly. Visit our citations database at: www.med-associates.com/citations/citations.htm.

If your citations are not in our database, feel free to submit them to us at: [email protected].

Amitai, Nurith and Athina Markou (2009). “Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration.” Psychopharmacology 202(1): 275-86.

Anker, Justin, Nathan Holtz, Natalie Zlebnik and Marilyn Carroll (2009). “Effects of allopregnanolone on the reinstatement of cocaine- seeking behavior in male and female rats.” Psychopharmacology 203(1): 63-72.

Baker, Lisa, John Panos, Bryan Killinger, Mary Peet, Lisa Bell, Larissa Haliw and Sheryl Walker (2009). “Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.” Psychopharmacology 203(2): 203-11.

Ballard, Theresa, Frédéric Knoflach, Eric Prinssen, Edilio Borroni, Jeffrey Vivian, Jennifer Basile, Rodolfo Gasser, Jean-Luc Moreau, Joseph Wettstein, Bernd Buettelmann, Henner Knust, Andrew Thomas, Gerhard Trube and Maria-Clemencia Hernandez (2009). “RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors.” Psychopharmacology 202(1): 207-23.

Bleickardt, C., D. Mullins, C. MacSweeney, B. Werner, A. Pond, M. Guzzi, F. Martin, G. Varty and R. Hodgson (2009). “Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior.” Psychopharmacology 202(4): 711-8.

Boulougouris, Vasileios, Anna Castañé and Trevor Robbins (2009). “Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior.” Psychopharmacology 202(4): 611-20.

Brown, Zenya, Erin Tribe, Nicole D’souza and Suzanne Erb (2009). “Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat.” Psychopharmacology 203(1): 121-30.

Buccafusco, Jerry, Scott Webster, Alvin Terry, Nancy Kille and Donna Blessing (2009). “Protracted cognitive effects produced by clonidine in Macaca nemestrina performing a delayed matching task.” Psychopharmacology 202(1): 477-85.

Carr, Kenneth, Soledad Cabeza de Vaca, Yanjie Sun and Lily Chau (2009). “Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction.” Psychopharmacology 202(4): 731-43.

Carr, Kenneth, Soledad de Vaca, Yanjie Sun, Lily Chau, Yan Pan and Julie Dela Cruz (2009). “Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of d -amphetamine and SKF-82958, and their augmentation by food restriction in rat.” Psychopharmacology 201(4): 495-506.

Chartoff, Elena, Matthew Barhight, Steve Mague, Allison Sawyer and William Carlezon (2009). “Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats.” Psychopharmacology.

Coen, Kathleen, K. Adamson and William Corrigall (2009). “Medication-related pharmacological manipulations of nicotine self-administration in the rat maintained on fixed- and progressive-ratio schedules of reinforcement.” Psychopharmacology 201(4): 557-68.

Cohen, Ami, Robert Young, Miguel Velazquez, Mariya Groysman, Kavon Noorbehesht, Osnat Ben-Shahar and Aaron Ettenberg (2009). “Anxiolytic effects of nicotine in a rodent test of approach–avoidance conflict.” Psychopharmacology.

Czachowski, Cristine and Michael DeLory (2009). “Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats.” Psychopharmacology.

Dwyer, Jason, Stacey Rizzo, Sarah Neal, Qian Lin, Flora Jow, Robert Arias, Sharon Rosenzweig-Lipson, John Dunlop and Chad Beyer (2009). “Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.” Psychopharmacology 203(1): 41-52.

12 || MedLines || spring 2009 recent citations [cont’d]

Faccidomo, Sara, Joyce Besheer, P. Stanford and Clyde Hodge (2009). “Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.” Psychopharmacology.

Fowler, Stephen, Jonathan Pinkston and Elena Vorontsova (2009). “Timing and space usage are disrupted by amphetamine in rats maintained on DRL 24-s and DRL 72-s schedules of reinforcement.” Psychopharmacology.

Fox, James H., Sayamwong E. Hammack and William A. Falls (2008). “Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.” Behavioral Neuroscience 122(4): 943-8.

Gass, Justin and M. Olive (2009). “Role of protein kinase C epsilon (PKCε) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.” Psychopharmacology.

Gatch, Michael, Margaret Rutledge, Theresa Carbonaro and Michael Forster (2009). “Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats.” Psychopharmacology.

George, S., P. Hutson and D. N. Stephens (2009). “Differential effects of MPEP and diazepam in tests of conditioned emotional response and Pavlovian-to-instrumental transfer suggests ‘anxiolytic’ effects are mediated by different mechanisms.” Psychopharmacology.

Gerak, Lisa (2009). “Selective changes in sensitivity to benzodiazepines, and not other positive GABAA modulators, in rats receiving flunitrazepam chronically.” Psychopharmacology. Goeders, Nicholas, David Clampitt, Courtney Gerak, Lisa, Ruggero Galici and Charles France (2009). “Self administration of heroin and cocaine Keller, Mukesh Sharma and Glenn Guerin (2009). in morphine-dependent and morphine-withdrawn rhesus monkeys.” Psychopharmacology. “Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats.” Psychopharmacology 201(4): 581-8.

Goodwin, A., P. Brown, E. Jansen, C. Jakobs, K. Gibson and E. Weerts (2009). “Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.” Psychopharmacology.

Henry, Porche’ and Leonard Howell (2009). “Cocaine-induced reinstatement during limited and extended drug access conditions in rhesus monkeys.” Psychopharmacology.

Ho, Ming-Che, Chianfang Cherng, Yen-Ping Tsai, Chih-Yuan Chiang, Jia-Ying Chuang, Shu-Fang Kao and Lung Yu (2009). “Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice.” Psychopharmacology.

Järbe, Torbjörn, Chen Li, Qian Liu and Alexandros Makriyannis (2009). “Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.” Psychopharmacology 203(2): 229-39.

Jentsch, J., Shawn Aarde and Emanuele Seu (2009). “Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats.” Psychopharmacology 202(1): 497-504.

Jewett, David, Thomas Hahn, Travis Smith, Britta Fiksdal, Jason Wiebelhaus, Andrew Dunbar, Catherine Filtz, Noah Novinska and Allen Levine (2009). “Effects of sibutramine and rimonabant in rats trained to discriminate between 22- and 2-h food deprivation.” Psychopharmacology 203(2): 453-9.

Justinova, Zuzana, Sergi Ferré, Chanel Barnes, Carrie Wertheim, Lara Pappas, Steven Goldberg and Bernard Le Foll (2009). “Effects of chronic caffeine exposure on adenosinergic modulation of the Ko, Tracey and John Evenden (2009). “The discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats.” Psychopharma- effects of psychotomimetic and putative cology 203(2): 355-67. cognitive-enhancing drugs on the performance of a n-back working memory task in rats.” Psychopharmacology 202(1): 67-78.

Koffarnus, Mikhail, Benjamin Greedy, Stephen Husbands, Peter Grundt, Amy Newman and James Woods (2009). “The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats.” Psychopharmacology 203(2): 317-27.

Kohut, Stephen, Peter Roma, Catherine Davis, Gerald Zernig, Alois Saria, Juan Dominguez, Kenner Rice and Anthony Riley (2009). “The impact of early environmental rearing condition on the discriminative stimulus effects and Fos expression induced by cocaine in adult male and female rats.” Psychopharmacology 203(2): 383-97.

LeSage, Mark (2009). “Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer.” Psychopharmacology 203(1): 13-22.

www.med-associates.com || 13 recent citations [cont’d]

Levy, AnneMarie, Elena Choleris and Francesco Leri (2009). “Enhancing effect of heroin on Li, Chen and Kyle Frantz (2009). “Attenuated social recognition learning in male Sprague–Dawley rats: modulation by heroin pre-exposure.” incubation of cocaine seeking in male rats Psychopharmacology. trained to self-administer cocaine during periadolescence.” Psychopharmacology.

Liu, Xiu, Matthew Palmatier, Anthony Caggiula, Alan Sved, Eric Donny, Maysa Gharib and Sheri Booth (2009). “Naltrexone attenuation of conditioned but not primary reinforcement of nicotine in rats.” Psychopharmacology 202(4): 589-98.

Marona-Lewicka, Danuta, Benjamin Chemel and David Nichols (2009). “Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.” Psychopharmacology 203(2): 265-77.

McMahon, Lance (2009). “Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Δ9-tetrahydrocannabinol.” Psychopharmacology 203(2): 219-28.

McMahon, Lance, Jun-Xu Li, F. Carroll and Charles France (2009). “Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys.” Psychopharmacology 203(2): 411-20.

Mueller, Devin, Lening Olivera-Figueroa, Daniel Pine and Gregory Quirk (2009). “The effects of yohimbine and amphetamine on fear expression and extinction in rats.” Psychopharmacology.

Nair, Sunila, Tristan Adams-Deutsch, Charles Pickens, Daniel Smith and Yavin Shaham (2009). “Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.” Psychopharmacology.

Oliveira, Amanda Ribeiro de, Adriano Edgar Reimer and Marcus Lira Brandão (2009). “Role of dopamine receptors in the ventral tegmental area in conditioned fear.” Behavioural Brain Research Oliver, Yolanda, Tamzin Ripley and David 199(2): 271-7. Stephens (2009). “Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine.” Psychopharmacology.

Overton, Donald, Gregg Stanwood, Bhavesh Patel, Sreenivasa Pragada and M. Gordon (2009). “Measurement of the lowest dosage of phenobarbital that can produce drug discrimination in rats.” Psychopharmacology 203(2): 213-8.

Panlilio, Leigh, Carmen Mazzola, Julie Medalie, Britta Hahn, Zuzana Justinova, Filippo Drago, Jean Cadet, Sevil Yasar and Steven Goldberg (2009). “Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats.” Psychopharmacology 203(3): 529-38.

Paola Roncada, Marco Bortolato Roberto Frau Pierluigi Saba Giovanna Flore Alessio Soggiu Salvatore Pisanu Angela Amoresano Andrea Carpentieri Paola Devoto (2009). “Gating deficits in isolation-reared rats are correlated with alterations in protein expression in nucleus accumbens.” Journal of Neurochemistry 108(3): 611-20.

Philibin, Scott, D. Walentiny, Sarah Vunck, Adam Prus, Herbert Meltzer and Joseph Porter (2009). “Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT2A serotonergic and α1 adrenergic antagonism.” Psychopharmacology 203(2): 303-15.

Phillips, Gavin and Paul Hitchcott (2009). “Blockade of the acquisition, but not expression, of asso- ciative learning by pre-session intra-amygdala Pickering, Chris, Johan Alsiö, Anna-Lena Hulting and Helgi Schiöth (2009). “Withdrawal from free- R (+) 7-OH-DPAT.” Psychopharmacology choice high-fat high-sugar diet induces craving only in obesity-prone animals.” Psychopharmacology. 203(1): 161-73. Prus, Adam, Alan Pehrson, Scott Philibin, Jesse Wood, Sarah Vunck and Joseph Porter (2009). “The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats.” Psychopharmacology 203(2): 295-301.

Quarta, Davide, Christopher Naylor, Jacques Barik, Cathy Fernandes, Susan Wonnacott and Ian Stolerman (2009). “Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release.” Psychopharmacology 203(2): 399-410.

14 || MedLines || spring 2009 recent citations [cont’d]

Salam, Jasmin N., James H. Fox, Ezra M. DeTroy, Michele H. Guignon, Dana F. Wohl and William A. Falls (2009). “Voluntary exercise in C57 mice is anxiolytic across several measures of anxiety.” Behavioural Brain Research 197(1): 31-40.

Schmajuk, N. A., J. A. Larrauri, L. G. De la Casa and E. D. Levin (2009). “Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms.” Behavioural Brain Research 197(2): 251-61.

Seu, Emanuele, Andrew Lang, Ronald Rivera and J. Jentsch (2009). “Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys.” Psychopharmacology 202(1): 505-19.

Shaw, David, Kelly Norwood, Kim Sharp, Lauren Quigley, Stephen McGovern and Julian Leslie (2009). “Facilitation of extinction of operant behaviour in mice by d -cycloserine.” Psychopharmacology 202(1): 397-402.

Talpos, J., B. Winters, R. Dias, L. Saksida and T. Bussey (2009). “A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease.” Psychopharmacology.

Wood, Suzanne and Stephan Anagnostaras (2009). “Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice.” Psychopharmacology 202(1): 197-206.

Woolley, M., K. Waters, J. Gartlon, L. Lacroix, C. Jennings, F. Shaughnessy, A. Ong, D. Pemberton, M. Harries, E. Southam, D. Jones and L. Dawson (2009). “Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3- benzoxadiazole (CX691), in the rat.” Psychopharmacology 202(1): 343-54.

Worden, Lila, Mona Shahriari, Andrew Farrar, Kelly Sink, Jörg Hockemeyer, Christa Müller and John Zhou, Wenhua, Fuqiang Zhang, Huifen Liu, Salamone (2009). “The adenosine A2A antagonist MSX-3 reverses the effort-related effects of Suien Tang, Miaojun Lai, Huaqiang Zhu and dopamine blockade: differential interaction with D1 and D2 family antagonists.” Psychopharmacology Peter Kalivas (2009). “Effects of training and 203(3): 489-99. • withdrawal periods on heroin seeking induced by conditioned cue in an animal of model of relapse.” Psychopharmacology 203(4): 677-84.

Submit your citations to us at: [email protected]

www.med-associates.com || 15 previous Issue 1 Issue 2 May 2007 June 2007 issues

Issue 3 Issue 4 Issue 5 July/Aug 2007 Sept/Oct 2007 Nov/Dec 2007

Issue 6 Issue 7 Issue 8 Jan/Feb 2008 Spring 2008 Winter 2009

www.med-associates.com www.med-associates.com Newsletter of the Zurn and Herrera Family Companies: the med associates newsletter Med Associates, Catamount R&D, Mansfield R&D, Razel Scientific Instruments, and Living Systems Instruments

Issue 7 || Spring 2008 issue 8 || winter 2009

Probing Spatial Memory in the Water Maze Power up! with the On-Demand (Atlantis) Platform feature: feature: Tips for setting up a new behavioral test system, without Learn how our recently released and economical On-Demand (Atlantis) getting lost in the wires.. 6 Platform can be used in Water Maze studies in order to minimize problems that confound interpretation of results from probe trials.

from the what’s new 3 founder 5 Read about our from the founder what’s new Read about the history upcoming Short Courses 2 Read the latest thoughts 4 Get an update on recent of behavioral instrumen- in Neuroscience for plus: from Karl Zurn about the evolu- conferences we exhibited at, plus: tation companies. Summer 2008. tion of behavioral instrumentation as well our purchase of Living companies. Systems Instrumentation.

product recent 10 particulars 11 citations who we are recent citations Meet Denver Wilson, Check out some of the Read about how to in- Check out some of the 10 11 electromechanical engineer. publications we’ve recently added crease lab efficiency publications we’ve to our citations database. with waste pan usage. recently added to our citations database.

Did you miss an issue?

Visit www.med-associates.com to catch up on previous issues and to sign up for MedLines online.

www.med-associates.com

PO Box 319, St. Albans, VT 05478 p (802) 527-2343 • f (802) 527-5095