Anti-ICAM3 Monoclonal Antibody, Clone Bu65 (CABT-46432MH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-ICAM3 monoclonal antibody, clone Bu65 (CABT-46432MH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse anti Human CD50 antibody, clone Bu65 recognizes human CD50, also known as Inter- cellular adhesion molecule-3 (ICAM-3). CD50 is an 110kD type I transmembrane glycoprotein which is expressed mainly on resting leukocytes. It interacts with lymphocyte function-associated antigen-1 (LFA-1) and DC-SIGN, and is involved in the intercellular adhesion of leukocytes and augments CD3 signalling in T-lymphocyte activation. CD50 expression induces cancer cell proliferation and over-expression may contribute to cancer progression. It has also been implicated in limiting HIV-1 replication. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Specificity ICAM3

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone Bu65

Conjugate Unconjugated

Applications FC; IP

Format Purified IgG - liquid

Size 200 μg

Preservative See individual product datasheet

Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Warnings For research purposes only

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol ICAM3

Synonyms ICAM3; intercellular adhesion molecule 3; CD50; CDW50; ICAM-R; ICAM-3; intercellular adhesion molecule-3;

Entrez Gene ID 3385

Protein Refseq NP_002153

UniProt ID P32942

Chromosome Location 19p13.3-p13.2

Pathway Adaptive Immune System; Cell adhesion molecules (CAMs); Extracellular matrix organization; IL-5 Signaling Pathway; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions;

Function integrin binding; protein binding; receptor binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]