Proceedings OF THE National Academy Sciences OF THE UNITED STATES OF AMERICA

January 18, 1994 Volume 91, Number 2 pp. 429-832 Table of Contents

CONDENSED INFORMATION FOR CONTRIBUTORS i

AUTHOR INDEX ix-x

Commentaries Insights into the role of the immune system in Leslie J. Berg 429-432 pnon diseases factors in inner ear development David P. Corey and Xandra 0. Breakefield 433-436 Antigen-specific immunotherapy: Is it a real possibility to combat Roland Tisch and Hugh 0. McDevitt 437-438 T-cell-mediated autoimmunity?

Physical Sciences Biological Sciences APPLIED MATHEMATICS BIOCHEMISTRY Diversity and virulence thresholds in AIDS 544-548 Staphylococcal folding intermediate 449-453 Rob J. de Boer and Maarten C. Boerlijst characterized by hydrogen exchange and NMR spectroscopy CHEMISTRY Marc D. Jacobs and Robert 0. Fox Double-stranded cleavage of pBR322 by a diiron 569-573 Identification of an essential serine residue 454-458 complex via a "hydrolytic" mechanism in glucagon: Implication for an active Leah M. T. Schnaith, Richard S. Hanson, and site triad Lawrence Que, Jr. Cecilia G. Unson and R. B. Merrifield

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Marked infidelity of human immunodeficiency virus 549-553 G proteins of the G12 family are activated via 504-508 type 1 reverse transcriptase at RNA and DNA thromboxane A2 and thrombin receptors in template ends human platelets Premal H. Patel and Bradley D. Preston Stefan Offermanns, Karl-Ludwig Laugwitz, Karsten Spicher, and Gunter Schultz Function of major histocompatibility complex class 554-558 II promoters requires cooperative binding between The parasitophorous vacuole membrane surrounding 509-513 factors RFX and NF-Y intracellular Toxoplasma gondii functions as a W. Reith, C.-A. Siegrist, B. Durand, E. Barras, molecular sieve and B. Mach J. C. Schwab, C. J. M. Beckers, and K. A. Joiner The iron-responsive element-binding protein: 574-578 C-y1 binding to intracellular receptors 559-563 Localization of the RNA-binding site to the aconitase for activated protein kinase C active-site cleft Marie-Helene Disatnik, S. M. Teresa James P. Basilion, Tracey A. Rouault, Christina Hernandez-Sotomayor, Gwenith Jones, Graham M. Massinople, Richard D. Klausner, and Wilson Carpenter, and Daria Mochly-Rosen H. Burgess Functional analysis of myosin missense in 589-593 Reconstitution of functional human single-stranded 579-583 familial hypertrophic cardiomyopathy DNA-binding protein from individual subunits Anthony J. Straceski, Anja Geisterfer-Lowrance, expressed by recombinant baculoviruses Christine E. Seidman, J. G. Seidman, and Leslie Evelyn Stigger, Frank B. Dean, Jerard Hurwitz, A. Leinwand and Suk-Hee Lee The B1C8 protein is in the dense assemblies of the 594-598 Targeted disruption of metallothionein I and II 584-588 nuclear matrix and relocates to the spindle and increases sensitivity to cadmium pericentriolar filaments at Brian A. Masters, Edward J. Kelly, Carol J. Katherine M. Wan, Jeffrey A. Nickerson, Gabriela Quaife, Ralph L. Brinster, and Richard D. Krockmalnic, and Sheldon Penman Palmiter Identification of dynamin 2, an isoform ubiquitously 644-648 Crucial role for DNA supercoiling in Mu 699-703 expressed in rat tissues transposition: A kinetic study Tiffany A. Cook, Raul Urrutia, and Mark A. Zhenggan Wang and Rasika M. Harshey McNiven Physical association and functional antagonism 752-756 Tat-mediated delivery of heterologous proteins 664-668 between the p65 subunit of transcription factor into cells NF-KB and the glucocorticoid receptor Stephen Fawell, Joe Seery, Yasmin Daikh, Claire Anuradha Ray and Karen E. Prefontaine Moore, Ling Ling Chen, Blake Pepinsky, and James Barsoum Enhancer 1 binding factor, a Ku-related protein, is a 762-766 positive regulator of RNA polymerase I Function of a human cyclin as an oncogene 709-713 transcription initiation Philip W. Hinds, Steven F. Dowdy, Elinor Ng Catherine M. Hoff, Asish K. Ghosh, Bellur S. Eaton, Andrew Arnold, and Robert A. Weinberg Prabhakar, and Samson T. Jacob Cloning of cDNAs for M-phase phosphoproteins 714-718 recognized by the MPM2 monoclonal antibody and BIOPHYSICS determination of the phosphorylated epitope Joanne M. Westendorf, Potu N. Rao, and Larry Identification of histidine at the catalytic site of the 704-708 Gerace photosynthetic oxygen-evolving complex Xiao-Song Tang, Bruce A. Diner, Barbara S. Insulin receptor substrate 1 is required for 797-801 Larsen, M. Lane Gilchrist, Jr., Gary A. Lorigan, insulin-mediated mitogenic signal transduction and R. David Britt David W. Rose, Alan R. Saltiel, Mousumi Majumdar, Stuart J. Decker, and Jerrold M. Predicting Ca2+-binding sites in proteins 817-821 Olefsky Murad Nayal and Enrico Di Cera DEVELOPMENTAL BIOLOGY CELL BIOLOGY Cardiac and skeletal myopathy in ( myosin 519-523 heavy-chain simian virus 40 tsA58 transgenic mice STK-1, the human homolog of Flk-2/Flt-3, is 459-463 Joshua R. De Leon, Howard J. Federoff, Dennis selectively expressed in CD34+ human bone marrow W. Dickson, Karen L. Vikstrom, and Glenn I. cells and is involved in the proliferation of early Fishman progenitor/stem cells Donald Small, Mark Levenstein, Eunkyung Kim, Cellular epigenetics: Topochronology of progressive 599-603 Cathy Carow, Shahina Amin, Patricia Rockwell, "spontaneous" transformation of cells under Larry Witte, Christopher Burrow, Mariusz Z. growth constraint Ratajczak, Alan M. Gewirtz, and Curt I. Civin Ming Chow, Adam Yao, and Harry Rubin

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Morphogenic potentials of D2, D3, and D4 dopamine 649-653 Negative regulation of early B lymphopoiesis by 469-473 receptors revealed in transfected neuronal cell lines interleukin 3 and interleukin la Barbara C. Swarzenski, Lei Tang, Young J. Oh, Fumiya Hirayama, Steven C. Clark, and Makio Karen L. O'Malley, and Richard D. Todd Ogawa Mouse limb muscle is determined in the absence of 747-751 The a/,B sheath and its cytoplasmic tyrosines are 474-478 the earliest myogenic factor myf-5 required for signaling by the B-cell antigen receptor Shahragim Tajbakhsh and Margaret E. but not for capping or for serine/threonine- Buckingham kinase recruitment G. T. Williams, C. J. G. Peaker, K. J. Patel, and M. S. Neuberger EVOLUTION Role and T the 604-608 What would be conserved if "the tape were of antibody cells in long-term inhibition of IgE synthesis played twice"? Seiji Haba and Alfred Nisonoff Walter Fontana and Leo W. Buss Minimum structural requirements for peptide 767-771 Weak male-driven molecular evolution in rodents 827-831 presentation by major histocompatibility Benny H.-J. Chang, Lawrence C. Shimmin, complex class II molecules: Implications Song-Kun Shyue, David Hewett-Emmett, and in induction of autoimmunity Wen-Hsiung Li Anand M. Gautam, Christopher B. Lock, Dawn E. Smilek, Cecelia I. Pearson, Lawrence Steinman, GENETICS and Hugh 0. McDevitt Ribosomal gene domains can function as 464-468 artificial enhancers of RNA polymerase I MEDICAL SCIENCES transcription, supporting a promoter origin for Relationship of a non-cystic fibrosis transmembrane 479-483 natural enhancers in Xenopus conductance regulator-mediated chloride Craig S. Pikaard conductance to organ-level disease in 524-528 Cftr(-/-) mice Detection of nondisjunction and recombination in Lane L. Clarke, Barbara R. Grubb, James R. meiotic and postmeiotic cells from XYsxr fluorescence Yankaskas, Calvin U. Cotton, Andrew McKenzie, [XY,Tp(Y)lCt] mice using multicolor and Richard C. Boucher in situ hybridization Terry Ashley, Thomas Ried, and David C. Ward Differential expression of two fibroblast growth 484-488 is associated with Stress-inducible gene of Salmonella typhimurium 639-643 factor-receptor genes malignant PCR of RNA progression in human astrocytomas identified by arbitrarily primed Fumio Janet M. Kwok and Michael McClelland Yamaguchi, Hideyuki Saya, Kwong Wong Bruner, and Richard S. Morrison Development of transforming function during 654-658 Somatic diversification in the heavy chain variable 514-518 transduction of proto-ras into Harvey sarcoma virus genes by human autoantibodies Matthias Lang, Iris Treinies, Peter H. Duesberg, region expressed bearing a lupus-associated nephritogenic Reinhard Kurth, and Klaus Cichutek anti-DNA idiotype The RNA of RNase MRP is required for normal 659-663 Christophe Demaison, Patricia Chastagner, processing of ribosomal RNA Jacques Theze, and Moncef Zouali H. Janice M. Seung Chu, Richard Archer, Zengel, Progesterone and RU486: Opposing effects on 529-533 and Lasse Lindahl human sperm Nature screen: An efficient method for screening 719-722 Jing Yang, Catherine Serres, Daniel Philibert, Paul natural populations of Drosophila for targeted Robel, Etienne-Emile Baulieu, and Pierre Jouannet P-element insertions Internal Ca2+ mobilization is altered in fibroblasts 534-538 Andrew G. Clark, Scott Silveria, Wendy Meyers, from patients with Alzheimer disease and Charles H. Langley Etsuro Ito, Kotaro Oka, Rend Etcheberrigaray, Allelic associations of two polymorphic 723-727 Thomas J. Nelson, Donna L. McPhie, Beth microsatellites in intron 40 of the human Tofel-Grehl, Gary E. Gibson, and Daniel L. Alkon von Willebrand factor gene Blocking of tumor promoter-induced AP-1 activity 609-613 Sergio D. J. Pena, Katia T. de Souza, Mariza inhibits induced transformation in JB6 mouse de Andrade, and Ranajit Chakraborty epidermal cells Zigang Dong, Michael J. Birrer, Rebecca G. IMMUNOLOGY Watts, Lynn M. Matrisian, and Nancy H. Colburn

Peptide-induced T-cell tolerance to prevent 444-448 Chronic active hepatitis in transgenic mice 614-618 autoimmune diabetes in a transgenic mouse model expressing interferon-y in the liver Peter Aichele, Diego Kyburz, Pamela S. Ohashi, Tetsushi Toyonaga, Okio Hino, Satoshi Sugai, Bernhard Odermatt, Rolf M. Zinkernagel, Hans Shoji Wakasugi, Kuniya Abe, Motoaki Shichiri, Hengartner, and Hanspeter Pircher and Ken-ichi Yamamura

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Establishment and characterization of differentiated, 674-678 Envelope glycoprotein gpl20 of human 494-498 nontransformed hepatocyte cell lines derived from immunodeficiency virus type 1 alters ion transport in mice transgenic for transforming growth factor a astrocytes: Implications for AIDS dementia complex Justina C. Wu, Glenn Merlino, and Nelson Fausto Dale J. Benos, Beatrice H. Hahn, James K. Bubien, Sajal K. Ghosh, Nicole A. Mashburn, Mice lacking N-acetylglucosaminyltransferase I 728-732 Margery A. Chaikin, George M. Shaw, and Etty activity die at mid-gestation, revealing an essential N. Benveniste role for complex or hybrid N-linked carbohydrates Ella Ioffe and Pamela Stanley Cloning and in situ localization of a brain-derived 499-503 porin that constitutes a large-conductance anion Hyperuricemia and urate nephropathy in urate 742-746 channel in astrocytic plasma membranes oxidase-deficient mice Rolf Dermietzel, Theng-Khing Hwang, Reinhard Xiangwei Wu, Maki Wakamiya, Sukeshi Vaishnav, Buettner, Andreas Hofer, Elisabeth Dotzler, Robert Geske, Charles Montgomery, Jr., Pamela Marian Kremer, Rainer Deutzmann, Friedrich T. Jones, Allan Bradley, and C. Thomas Caskey Thinnes, Glenn I. Fishman, David C. Spray, and Detlef Siemen An integral membrane protein (LMP2) blocks 772-776 reactivation of Epstein-Barr virus from latency Regional, cellular, and ultrastructural distribution of 564-568 following surface immunoglobulin crosslinking N-methyl-D-aspartate receptor subunit 1 in Cheryl L. Miller, Jennifer H. Lee, Elliott Kieff, monkey hippocampus and Richard Longnecker S. J. Siegel, N. Brose, W. G. Janssen, G. P. Gasic, R. Jahn, S. F. Heinemann, and J. H. Genetic heterogeneity of hepatocellular carcinoma 822-826 Morrison Hilal Unsal, Cengiz Yakicier, Christophe Margais, Micheal Kew, Martin Volkmann, Hans Zentgraf, Waves and stimulus-modulated dynamics in an 669-673 Kurt J. Isselbacher, and Mehmet Ozturk oscillating olfactory network K. R. Delaney, A. Gelperin, M. S. Fee, J. A. Flores, R. Gervais, D. W. Tank, and D. Kleinfeld MICROBIOLOGY Monoclonal antibodies to nerve growth factor affect 684-688 A cytolysin encoded by Salmonella is required for 489-493 the postnatal development of the visual system survival within macrophages N. Berardi, A. Cellerino, L. Domenici, M. Stephen J. Libby, Werner Goebel, Albrecht Fagiolini, T. Pizzorusso, A. Cattaneo, and L. Ludwig, Nancy Buchmeier, Frances Bowe, Ferric Maffei C. Fang, Donald G. Guiney, J. Glenn Songer, and Fred Heffron A rapid capsaicin-activated current in rat trigeminal 738-741 ganglion neurons The polymorphic subtelomeric regions of 619-623 L. Liu and S. A. Simon Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements Facilitation of glutamate receptors enhances memory 777-781 Derik de Bruin, Michael Lanzer, and Jeffrey V. Ursula Staubli, Gary Rogers, and Gary Lynch Ravetch Eye position and eye velocity integrators reside in 807-811 Light-harvesting chlorophyll c-like pigment 679-683 separate brainstem nuclei in Prochloron Angel M. Pastor, Rosa R. De la Cruz, and Robert A. W. D. Larkum, C. Scaramuzzi, G. C. Cox, Baker R. G. Hiller, and A. G. Turner Chromostatin inhibits catecholamine secretion in 832 Foot-and-mouth disease virus particles contain 733-737 adrenal chromaffin cells by activating a protein replicase protein 3D (Correction) J. F. E. Newman, P. G. Piatti, B. M. Gorman, Estelle Galindo, Jean Zwiller, Marie-France Bader, T. G. Burrage, M. D. Ryan, M. Flint, and F. Brown and Dominique Aunis

Translation elongation factor Tu cleaved by a 802-806 phage-exclusion system PHYSIOLOGY Yuen-Tsu Nicco Yu and Larry Snyder Role of nitric oxide in eicosanoid synthesis and 539-543 uterine motility in estrogen-treated rat uteri NEUROBIOLOGY Ana Maria Franchi, Marcela Chaud, Valeria Rettori, Angela Suburo, Samuel M. McCann, and a and thyroid hormone receptor (TR) gene 439-443 Martha Gimeno expression during auditory neurogenesis: Evidence for TR isoform-specific transcriptional regulation Molecular basis of cardiac potassium channel 624-628 in vivo stimulation by protein kinase A David J. Bradley, Howard C. Towle, and W. Scott Xin-Yun Huang, Anthony D. Morielli, and Ernest Young III G. Peralta

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Growth hormone-releasing factor increases 782-786 PLANT BIOLOGY somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase Evidence for RNA editing in mitochondria 629-633 M. C. Aguila of all major groups of land plants except the Bryophyta Pineal control of aging: Effect of melatonin and 787-791 Rudolf Hiesel, Bruno Combettes, and Axel pineal grafting on aging mice Brennicke Walter Pierpaoli and William Regelson Regulation of activity and apical targeting of the 792-7% Plant mitochondrial nucleic acid sequences as a tool 634-638 Cl-/HCO3 exchanger in rat hepatocytes for phylogenetic analysis Antonio Benedetti, Mario Strazzabosco, Oi Cheng Rudolf Hiesel, Arndt von Haeseler, and Axel Ng, and James L. Boyer Brennicke Antibody to intercellular adhesion molecule 1 812-816 protects the kidney against ischemic injury Photoaffinity labeling of Arabidopsis thaliana plasma 689-693 K. J. Kelly, Winfred W. Williams, Jr., Robert B. membrane vesicles by 5-azido-[7-3H]indole-3-acetic Colvin, and Joseph V. Bonventre acid: Identification of a glutathione S-transferase Rolf Zettl, Jeff Schell, and Klaus Palme PHYSIOLOGY/PHARMACOLOGY Chromostatin, a 20-amino acid peptide derived from 832 Agrobacterium T-strand production in vitro: Sequence- 694-698 chromogranin A, inhibits chromaffin cell secretion specific cleavage and 5' protection of single-stranded (Correction) DNA templates by purified VirD2 protein Estelle Galindo, Attila Rill, Marie-France Bader, Fred Jasper, Csaba Koncz, Jeff Schell, and and Dominique Aunis Hans-Henning Steinbiss

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