From: ITNDaily Subject: Mount Sinai In The News - January 2, 2018 Date: Tuesday, January 02, 2018 12:42:24 PM Attachments: ATT00001.txt

In the News January 2, 2018

Politico New York – January 2 Have Macrophage, Will Travel — Dan Goldberg Mount Sinai researchers, writing in Nature Communications, say the macrophages that reside in healthy breast tissue surrounding milk ducts play a large role in helping early breast cancer cells travel to other parts of the body. The hope is that these findings could help identify biomarkers in patients at greater risk of carrying metastatic cells. - Icahn School of Medicine at Mount Sinai Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/01/02/dfs-looking-to-help-munis- purchase-health-insurance-020627

Cancer Network – December 30 Could Single-Cell RNA Sequencing Help Personalize Multiple Myeloma Treatment? — Samir Parekh, MD Samir Parekh, MBBS, associate professor of medicine, hematology, medical oncology, and oncological sciences at the Icahn School of Medicine at Mount Sinai, highlights a study that shows that patients with relapsed multiple myeloma may need highly individualized therapy to overcome the complexity of relapsed disease. The researchers found that single-cell RNA sequencing can better characterize patients and potentially improve treatment in a more personalized manner. Results of the study were presented at the 2017 American Society of Hematology Annual Meeting and Exposition in Atlanta. - Samir Parekh, MBBS, Associate Professor, Medicine, Hematology, Medical Oncology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.cancernetwork.com/ash-street-team/could-single-cell-rna-sequencing-help-personalize-multiple-myeloma-treatment

HFMA: Leadership+ – November 2017 48 Hours To Find A Healthcare Fix – Laura Ramos Hegwer An annual healthcare hackathon at Mount Sinai Health System offers young technology entrepreneurs, computer scientists and engineers, medical and allied healthcare professionals and trainees a forum to seek innovative solutions that improve care. Leaders at Mount Sinai say they developed their health hackathon to cultivate an ecosystem that fosters multi- and transdisciplinary team-based health tech innovation and entrepreneurship. Along with fostering a culture of innovation, the organization seeks to generate new technologies in the hope that some may have commercial potential, said Scott Friedman, MD, dean of therapeutic discovery and chief of liver disease for the Mount Sinai Health System. Mount Sinai differentiates itself from some other organizations that host healthcare hackathons by offering participants a real-life, front-line connection to the challenges of managing patients within an academic healthcare setting. This year’s Health Hackathon theme was cancer, which posed countless opportunities for problem-solving, said Ramon Parsons, MD, PhD, director of the Tisch Cancer Institute at Mount Sinai. “Software tools and devices that would help with patient navigation, disease monitoring, or even securing electronic consent for research studies would be extremely helpful and benefit patients,” he said. - Scott Friedman, MD, Dean, Therapeutic Discovery, Fishberg Professor, Medicine, Professor, Liver Diseases, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, Chief, Liver Diseases, The Mount Sinai Health System - Ramon Parsons, MD, PhD, Director, The Tisch Cancer Institute at Mount Sinai, Professor, Chair, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Peter Backeris, Bioengineer, Icahn School of Medicine at Mount Sinai - Janice Gabrilove, MD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.hfma.org/Leadership/E-Bulletins/2017/November/48_Hours_to_Find_a_Healthcare_Fix/

Daily Nurse – December 29 Mount Sinai Beth Israel Receives Nursing Workforce Diversity Grant — Christina Morgan The Philips School of Nursing (PSON) at Mount Sinai Beth Israel recently received a Nursing Workforce Diversity grant of $800,000 from the US Health Resources and Services Administration (HRSA). The four-year HRSA grant is intended to help increase access to nursing education for students from diverse backgrounds. Carleen Graham, MSN, RN, program coordinator, Philips School of Nursing at Mount Sinai Beth Israel, will serve as program director for WIN, which will follow 21 students from entry to graduation throughout the grant period. “It is an honor to be given such an amazing opportunity and responsibility. It is not only important to our school; it is important to our future nurses and the communities they will serve. This grant will help to address the shortage of nurses from underrepresented groups in New York City – considered to be one of the most diverse cities in the country. We are extremely excited to begin work on this important initiative,” said Graham. - Carleen Graham, MSN, RN, Program Coordinator, Philips School of Nursing at Mount Sinai Beth Israel Learn more: http://dailynurse.com/mount-sinai-beth-israel-receives-nursing-workforce-diversity-grant/

Medpage Today – December 28 Sham Controls In Device Trials Gain Favor After ORBITA — Crystal Phend The ORBITA trial earned a place in the halls of cardiology fame (or infamy, depending on one's view) when it reported that percutaneous coronary intervention (PCI) was no better than a sham procedure for stable angina. But one of the key messages, observed by many, was not the clinical impact -- which it is sure to have -- but that sham procedures can, and perhaps should, be done in PCI trials. Roxana Mehran, MD, professor of medicine, cardiology, population health and policy, director of the interventional cardiovascular research and clinical trials and the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, while a critic of the trial, argued that the focus should be on "the importance of this trial, which was to show that a controlled, placebo procedure is actually possible when we are questioning the need for procedure." - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/pci/70157

Healio – December 14 Pathologic Complete Response May Be Strong Surrogate Endpoint For Breast Cancer Survival Charles Shapiro, MD, director of cancer survivorship and translational breast cancer research at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, offers a perspective on the above referenced study: “For a long time, we knew that pathologic complete response rate was a good endpoint, meaning that the higher the pathologic complete response rate with neoadjuvant therapy, the better patients did. What we didn’t know was whether it correlated with long-term favorable outcomes like EFS and distant RFS. The question was: Did achieving a pathologic complete response mean anything for long-term clinical outcomes? This trial was ideally suited to answer this question. What researchers showed was that, indeed, complete pathologic response rate is a surrogate for EFS and distant RFS. It can’t yet be inferred that it can be surrogate for OS, but it stands to reason that it will.” - Charles Shapiro, MD, Director, Cancer Survivorship, Translational Breast Cancer Research, The Tisch Cancer Institute, Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/hematology-oncology/breast-cancer/news/online/%7Bef518d49-a55c-4727-b19d- b383ad1e2859%7D/pathologic-complete-response-may-be-strong-surrogate-endpoint-for-breast-cancer-survival

The New York Times – December 29 Does a ‘Strong’ Immune System Ward Off Colds and Flu? — Karen Weintraub “What makes people sick is a combination of bad luck — exposures to viruses or other pathogens — and the state of their immune system,” said Talia Swartz, MD, PhD, assistant professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai.” Someone with a weakened immune system is likely to be more vulnerable to passing bugs than someone with a healthy one.” There are definitely different types of patients who are more resistant to infections or who have slower progression of infectious diseases based on certain immune features we recognize that make them have a stronger immune system. “Frequent hand washing is crucial for keeping bugs from entering the mouth, nose and eyes, where they can spread infections,” added Dr. Swartz. She also recommended annual flu shots to attempt to prevent flu or reduce its severity. Other vaccinations, like the new shingles one, which is now recommended for people 50 and older, are also a good idea to help the immune system. - Talia Swartz, MD, PhD, Assistant Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2017/12/29/well/live/does-a-strong-immune-system-ward-off-colds-and-flu.html

The New York Times – December 31 Fire Department Finds A Way Around Times Square Traffic For Medical Emergencies — Jan Ransom An ambulance, with its siren wailing and lights flashing, was unable to move, stuck in gridlocked traffic one recent afternoon along Eighth Avenue in Times Square. Some drivers tried to get out of the way even as pedestrians hurried past. But it was too late. The light changed and vehicles from a nearby street spilled onto the clogged roadway, causing further congestion. Scenes like these are common for emergency medical workers in Times Square, one of the most crowded places in the country. New York Fire Department Commissioner came up with a potential solution: A unit of emergency medical workers would use small two-passenger vehicles, called gator utility vehicles, instead of ambulances to respond to emergencies. The gator vehicles, which are the size of a golf cart, are equipped with a chair, a defibrillator, an oxygen bag and medical supplies, and they are small enough to drive on bike lanes and squeeze through Midtown Manhattan’s bumper-to-bumper traffic and through tight pathways between Broadway theaters. “When we think about patients who are having a life-threatening emergency like a heart attack, arrhythmia or a stroke — these are very time-sensitive conditions,” said Erick Eiting, MD, director of emergency medicine and urgent care at Mount Sinai Beth Israel and Mount Sinai Union Square. “A delay of even a few minutes can be the difference between life and death and the difference between someone being able to recover with no disability.” - Erick Eiting, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Medicine and Urgent Care, Mount Sinai Beth Israel, Mount Sinai Union Square Learn more: https://www.nytimes.com/2017/12/31/nyregion/fire-department- medical-emergencies-times-square-nyc.html?ribbon-ad- idx=8&rref=nyregion&module=Ribbon&version=context®ion=Header&action=click&contentCollection=N.Y.%20%2F%20Region&pgtype=article mHealthIntelligence – December 29 Telehealth Offers A Platform For Discussing Sensitive Health Issues — Eric Wicklund A Silicon Valley startup using telehealth to help men with erectile dysfunction is the latest example of a digital health platform being used to connect patients with providers to have discussions they might not have in person. Healthcare providers often see telehealth as an ideal platform for connecting with their patients on sensitive issues. "Some patients have been told it's a problem in their head so they suffer but don't follow up for years. Telehealth can increase access to excellent sexual health care for men who have emotional or geographic barriers keeping them out of the office," added Doron Stember, MD, assistant professor of urology at the Icahn School of Medicine at Mount Sinai. "But medications have real risks, and some patients have specific conditions that should be considered as part of treatment decisions. Patients should only use telehealth platforms that can provide the standard of individualized care they'd expect in specialists' offices.” - Doron S. Stember, MD, Assistant Professor, Urology, Icahn School of Medicine at Mount Sinai Learn more: https://mhealthintelligence.com/news/telehealth-offers-a-platform-for-discussing-sensitive-health-issues

Reuters – December 29 Cigarette Smoking During Pregnancy Linked To ADHD Risk In Offspring — Cheryl Platzman Weinstock Children born to women who smoke cigarettes during pregnancy, especially when mothers are heavy smokers, are at an increased risk for attention-deficit/hyperactivity disorder (ADHD), a new review of medical studies confirms. Mothers who smoked during pregnancy had an overall 60 percent higher risk of having a child with ADHD compared to women who didn’t smoke. For mothers who smoked fewer than 10 cigarettes per day, the risk of having a child who developed ADHD was 54 percent higher than for nonsmoking mothers. For mothers who were heavier smokers, the risk was 75 percent higher than for nonsmokers. The team found lower risks for ADHD in children of mothers who smoked in the U.S. and Europe, where more smokers stop smoking when they get pregnant. “It would be a big leap from that, but if you are a prior smoker and stop during pregnancy, the inference is that the risk of ADHD goes down,” said Jeffrey Newcorn, MD, professor of psychiatry, pediatrics, and director of The Center of Excellence in ADHD and Related Disorders at the Icahn School of Medicine Mount Sinai. - Jeffrey Newcorn, MD, Professor, Psychiatry, Pediatrics, Director, The Center of Excellence in ADHD and Related Disorders, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-pregnancy-smoking-adhd/cigarette-smoking-during-pregnancy-linked-to-adhd-risk-in- offspring-idUSKBN1EN1M9

Medpage Today – December 29 A More Personalized Approach To PSA Screening In 2017 — Alexandria Bachert, MPH In April the U.S. Preventative Services Task Force released an updated recommendation supporting individualized decision-making for PSA- based prostate cancer screening among men ages 55 to 69 years old. The release stated that men should have the opportunity to weigh the potential benefits and harms of screening and make a decision based on their own values and preferences. William K. Oh, MD, professor of medicine, hematology, medical oncology, and urology, and deputy director of the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, shared a cautious perspective: “When the previous recommendation was announced that patients should not be screened at all, I do think it decreased screening rates," he explained. "I think this change will slowly increase screening again, but I don't think it will happen quickly. Unfortunately, I think these rapid back-and-forth changes have the effect of causing clinicians to become confused and potentially not respond to guidelines." - William Oh, MD, Professor, Medicine, Hematology, Medical Oncology, Urology, Deputy Director, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/urology/prostatecancer/70181

Medscape – December 29 Scoring System May Predict Which BE Patients Will Progress To Cancer — Marilynn Larkin A newly developed scoring system may be able to identify patients with Barrett’s esophagus (BE) at low, intermediate, and high risk for progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), researchers say. Yujin Hoshida, MD, PhD, associate professor of medicine and liver diseases at the Icahn School of Medicine at Mount Sinai commented, “The risk score was developed and validated in a large collection of multicenter patient cohorts with long-term follow-up using clinically readily available variables.” He added that, “Therefore, it is expected that the robustness and clinical applicability of the score is high, and such a score will make monitoring of patients at risk of developing esophageal cancer more efficient and cost-effective. External validation and head-to-head comparison with previously reported scores will further elucidate the clinical utility of the score.” - Yujin Hoshida, MD, PhD, Associate Professor, Medicine, Liver Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/890691

Healio – December 7 Ixabepilone Remains Inferior To Paclitaxel In Metastatic Disease Ixabepilone appeared inferior to paclitaxel and nab-paclitaxel in terms of OS among patients with locally recurrent or metastatic breast cancer, according to long-term follow-up of a phase 3 clinical trial presented at the San Antonio Breast Cancer Symposium. Charles Shapiro, MD, director of cancer survivorship and translational breast cancer research at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai said, “This is the long-term follow-up study of data presented in 2013. The next thing to consider is that there were no significant differences between the nab-paclitaxel and paclitaxel arms. They also show that nab-paclitaxel appeared to do better for patients with triple-negative breast cancers, whereas paclitaxel appeared to do better for ER-positive breast cancer patients. That was interesting, and may be true. However, these findings are from a post-hoc subset analysis, which means they have been interpreted very cautiously and they could easily be wrong.” - Charles Shapiro, MD, Director, Cancer Survivorship, Translational Breast Cancer Research, The Tisch Cancer Institute, Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/hematology-oncology/breast-cancer/news/online/%7B1887dfa1-c071-4fe6-b40e- f41e0be868a3%7D/ixabepilone-remains-inferior-to-paclitaxel-in-metastatic-disease

New York Post – December 25 I Survived A Horrible Crash – And Now I Want A Car For Christmas — Linda Massarella A college student whose body was split apart in an auto accident – prompting even her surgeon to cry when she first wiggled her toes again – says there is only one Christmas gift she wants: another car. “She was ripped in half,” said David Forsh, MD, assistant professor of orthopedics at the Icahn School of Medicine at Mount Sinai and chief of orthopedic trauma at the Mount Sinai Health System. The student had to be revived from death three times before she stabilized and could be operated on, said Dr. Forsh. “Of all the cases I’ve done, she was the one that I lost the most sleep about, wondering if she would stand up and walk or be paralyzed,” Dr. Forsh added. Although she has a long way to go – she continues to use a colostomy bag and undergo physical therapy for her leg – Dr. Forsh said she has nonetheless made a “miraculous recovery.” “She had a lot of muscles from track and weight-lifting but more importantly, she has a fighting character. The people around her were fighting for her,’’ Dr. Forsh said. “She is an outlier and an exception.” - David Forsh, MD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Orthopedic Trauma, Mount Sinai Health System Learn more: https://nypost.com/2017/12/25/i-survived-a-horrible-crash-and-now-i-want-a-car-for-christmas/

HealthDay – January 2 Getting Back In Shape In 2018? Great, But Do It Safely – Dennis Thompson Getting into shape or losing a few pounds is a worthy New Year's resolution, but one that comes with a warning: Take it slow. Jumping whole- hog into an exercise regime is a good way to get yourself hurt if you haven't worked out for a while, experts say. "People get into trouble when they want to do too much too soon," said Gerardo E. Mirando-Comas, MD, assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai. “You need to increase your level of activity gradually. Consider it more like a marathon than a sprint,” added. Dr. Mirando-Comas. Keep an eye out for fatigue, chest pain or dizziness as you're working out -- these could be signs that you're working too hard, Dr. Miranda-Comas said. Trouble sleeping or being in a perpetual bad mood could be signs of overtraining as well. Consider taking a step back or consulting your doctor. - Gerardo E. Miranda-Comas, MD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/mental-health-information-25/behavior-health-news-56/getting-back-in-shape-in-2018-great-but-do- it-safely-729748.html Additional coverage: The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay729748_20180102_Getting_Back_in_Shape_in_2018__Great__but_Do_It_Safely.html

Metro NY – December 28 What You Need To Know About UTIs — Sheila Dougherty UTI, or urinary tract infection, is an infection of the bladder or lower urinary tract. UTIs can be either complicated or uncomplicated depending upon a patient’s risk factors or medical co-morbidities. Zoe Rodriguez, MD, vice chair of operations and medical director of ambulatory services in the department of obstetrics and gynecology at Mount Sinai Downtown discusses the causes and how you can prevent them. “UTIs are most commonly caused by gastrointestinal or fecal flora seeding of the vagina and or urethra and traveling to the bladder,” Dr. Rodriguez said. “If UTIs are left untreated, the infection may continue up from the bladder to the upper urinary tract and lead to the infection of the kidneys. This may lead to septicemia, or infection of the blood,” she added. - Zoe Rodriguez, MD, Vice Chair, Operations, Medical Director, Ambulatory Services, Department of Obstetrics and Gynecology, Mount Sinai Downtown, Assistant Professor, Obstetrics, Gynecology, Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.metro.us/body-and-mind/health/urinary-tract-infection-treatment

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 3, 2018 Date: Wednesday, January 03, 2018 2:10:42 PM Attachments: ATT00001.txt

In the News __ January 3, 2018

NPR News – January 2 Hospitals Play Significant Role In Racial Disparities For Premature Babies In NYC — Aneri Pattani Premature babies face a host of dangers. Born before 37 weeks, they often have underdeveloped organs and an increased susceptibility to infection. But some preemies are at even greater risk, simply because of where they’re born. A new study from Icahn School of Medicine at Mount Sinai found that children born at certain New York City hospitals are at significantly greater risk for death or severe complications that can leave them with lifelong disabilities. And those children tend to be black or Hispanic. Previous research has focused on infant factors like gestational age and birthweight as causes for the disparity in outcomes for premature babies. The Mount Sinai study explored hospitals as another contributing factor. “We found infant factors were the biggest contributor to disparity,” said co-author Elizabeth Howell, MD, MPP, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean of academic development and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai. “But hospital of birth was the second factor.” They don’t know what’s behind that variation. Dr. Howell said it could be anything from quality of care to the use of evidence-based practices. She added that it’s an important area for future research. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.wnyc.org/story/variation-nyc-hospitals-contributes-racial-disparity-premature-babies/ Additional coverage: Reuters https://www.reuters.com/article/us-health-preemies-race/race-may-matter-in-hospital-care-for- preemies-idUSKBN1ER1LH? feedType=RSS&feedName=healthNews&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A Modern Healthcare http://www.modernhealthcare.com/article/20180102/NEWS/180109998 Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/03/albany-session-begins-020982 Crain’s Health Pulse http://www.crainsnewyork.com/article/20180103/PULSE/180109987/the-grand-healthcare- system-seeks-to-buy-two-long-island-nursing (Subscription required) MedPage Today https://www.medpagetoday.com/pediatrics/generalpediatrics/70252 Medscape https://www.medscape.com/viewarticle/890780 Compton Herald http://comptonherald.org/hospitals-failing-black-mothers/

Reuters – January 2 Immune Cells Linked To Very Early Spread Of Breast Cancer — Marilynn Larkin Normal immune cells that live near milk ducts in healthy breast tissue may play a key role in helping early breast cancer cells leave the breast for other parts of the body, researchers say. This could possibly cause cancer to metastasize, or spread, even before a tumor has developed, according to Julio Aguirre-Ghiso, PhD, professor of medicine, hematology, medical oncology, otolaryngology, and oncological sciences at the Icahn School of Medicine at Mount Sinai. The study was published in Nature Communications. In the current study, the team reports that immune cells called macrophages play an important role in this process. Working in mice and in human cells in the laboratory, the team found that dissemination occurs when macrophages are attracted to the milk ducts, where they trigger a chain reaction that enables the early cancer cells to leave the breast. “We show that by disrupting this process, we can prevent early dissemination and, ultimately, deadly metastasis” explained Dr. Aguirre-Ghiso. “Our study challenges the dogma that early diagnosis and treatment means sure cure.” It could also be a starting point for a test that could identify patients with the earliest form of breast cancer, known as ductal cell carcinoma in situ, who may already have disseminated disease, he suggested. - Julio Aguirre-Ghiso, PhD, Professor, Medicine, Hematology, Medical Oncology, Otolaryngology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-metastasis-breast-cancer/immune-cells-linked-to-very- early-spread-of-breast-cancer-idUSKBN1ER1F3 Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-01-immune-cells-key-role-early.html Science Daily https://www.sciencedaily.com/releases/2018/01/180102103323.htm Business Insider http://www.businessinsider.com/r-immune-cells-linked-to-very-early-spread-of-breast-cancer- 2018-1 TekCrispy https://www.tekcrispy.com/2018/01/02/celulas-inmunes-metastasis-cancer-mama/ Newsmax Health https://www.newsmax.com/health/health-news/immune-cells-breast- cancer/2018/01/03/id/834839/

New York Law Journal – January 2 On The Move The Mount Sinai Medical Legal Partnership, which offers free legal services to vulnerable patients, has appointed Barbara Berger Opotowsky as president. She joins MSMLP after serving for 15 years as the executive director of the New York City Bar Association. - Barbara Berger Opotowsky, President, Mount Sinai Medical Legal Partnership Learn more: https://www.law.com/newyorklawjournal/sites/newyorklawjournal/2018/01/02/on-the-move-28/? slreturn=20180002171044 Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180103/PULSE/180109987/the-grand-healthcare- system-seeks-to-buy-two-long-island-nursing (Subscription Required)

Crain’s Health Pulse – January 3 Who’s News Melanie Ongchin, MD, is the new medical director of surgical oncology at Valley-Mount Sinai Comprehensive Cancer Care. Dr. Ongchin was previously an assistant professor of surgery at Weill Cornell Medical College and an attending surgeon at New York-Presbyterian. - Melanie Ongchin, MD, Medical Director, Surgical Oncology, Valley-Mount Sinai Comprehensive Cancer Care, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180103/PULSE/180109987/the-grand-healthcare-system- seeks-to-buy-two-long-island-nursing (Subscription Required)

Medpage Today – January 2 This Year’s Top Eye Stories: Detergent Burns, Solar Retinopathy, And More — Judy George Acute solar retinopathy can lead to localized foveal cone photoreceptor injury, according to a case report of a woman treated at the New York Eye and Ear Infirmary of Mount Sinai. During the eclipse, a young woman viewed the solar rim several times for approximately six seconds without protective glasses, then again for about 15 to 20 seconds with a pair of eclipse glasses. Four hours later, she noted blurred vision, metamorphopsia, and color distortion which were worse in her left eye, according to Avnish Deobhakta, MD, assistant professor of vitreoretinal surgery and ophthalmology at the Icahn School of Medicine at Mount Sinai. The patient also reported seeing a central black spot in her left eye. “When severe, solar retinopathy can cause an absolute scotoma,” authors wrote. “Young adults may be especially vulnerable and need to be better informed of the risks of directly viewing the sun without protective eyewear.” - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/ophthalmology/generalophthalmology/70245

CBS New York – January 2 Tips, Tricks For Beating Back The Cold & Flu Blues — Max Gomez Doctors say cold and flu season is in full swing, and that’s leaving a lot of folks feeling pretty lousy. But there are some things you can do to feel better, and some you probably should avoid. There’s no cure for the common cold and the flu only responds to antiviral medications if they’re taken in the first 48 hours of symptoms. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital said they’re seeing a recent uptick in cases. “Both upper respiratory infections and influenza, and data says flu season is definitely ramping up into full force,” Dr. Shearer said. He added that tea with some honey is a decent home remedy for a cough and sore throat. Other symptoms can usually be handled at the drugstore, but it’s important to read those medicine labels carefully. “OTC medications can handle almost all the symptoms, whether it’s a cough or a cold or influenza. A lot of meds are mixtures, combos of three or four meds. I steer people away from those into what exactly they need.” In children and the elderly, Dr. Shearer said it’s important to watch out for confusion or altered mental status, which could be a sign of something more than just a viral infection which would require a trip to the emergency room. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://newyork.cbslocal.com/2018/01/02/cold-and-flu-remedies/

Pix11 News – December 29 New York City May Have Coldest New Year’s Eve In Decades — Allison Kaden The ball won’t be the only thing dropping on New Year’s Eve. The temperature in New York City could drop into the low teens or single digits. About a million people gather in Times Square to ring in the New Year, and this extreme cold could put a damper on the festivities. According to Erick Eiting, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai, director of emergency medicine and urgent care for Mount Sinai Downtown, exposure to the cold for a long period of time could be dangerous. “If you were thinking this is the year to go and watch the ball drop, maybe you better rethink that decision,” he said. He added that people shouldn’t drink in cold weather because alcohol “opens your blood vessels and can help make you more prone to things like frostbite.” When the temperature dips into the low teens and single digits, Dr. Eiting said frostbite and hypothermia are a real threat. - Erick Eiting, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Medicine and Urgent Care, Mount Sinai Beth Israel, Mount Sinai Union Learn more: http://pix11.com/2017/12/29/new-york-city-may-have-coldest-new-years-eve-in-decades/

Medpage Today – December 30 Thumbs Up For Latest CAR T-Cell Approval — Charles Bankhead The approval of a second CAR T-cell therapy within 2 months signals the start of expanded investigation of the therapy in hematologic malignancies and possibly beyond. Approved by the FDA for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), axi-cel (Yescarta) enters a larger disease field as compared with tisagenlecleucel (Kymriah), which received FDA approval for children and young adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. DLBCL is the most common form of non- Hodgkin's lymphoma (NHL) and often has an aggressive clinical course. James L.M. Ferrara, MD, DSc, professor of pediatrics, oncological sciences and medicine, hematology and medical oncology at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai called the FDA action “great news for cancer patients.” The approval, he said, “proves that gene therapy is here to stay, and is likely to help increasing numbers of patients with terrible blood cancers that don’t respond to standard treatments. There are highly personalized therapies, and this success will accelerate efforts to make such treatments available for large numbers of patients.” - James L.M. Ferrara, MD, DSc, Professor of Pediatrics, Oncological Sciences and Medicine, Hematology and Medical Oncology at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and Co- director of Mount Sinai Acute GVHD International Consortium (MAGIC) Learn more: https://www.medpagetoday.com/hematologyoncology/hematology/70211

Medscape – December 11 Blood Transfusions In Leukemia A Deterrent To Hospice Care — Roxanne Nelson, RN, BSN Secondary endpoints were National Quality Forum performance measures for palliative and end-of-life care (ICU use within 30 days of death, chemotherapy in the last 14 days of life, hospice enrollment more than three days before death, and hospice enrollment via outpatient referral) and Medicare spending in the last 30 days of life. Of this group, 20 percent were transfusion dependent before their death/hospice enrollment. Patients who were transfusion dependent tended to be significantly younger, were more often male, and more often had acute leukemia. "The paper shows that leukemia patients are increasingly being enrolled in hospice but those who need blood transfusions are getting enrolled much later," said Cardinale Smith, MD, associate professor of medicine, hematology, medical oncology, geriatrics, palliative medicine at the Icahn School of Medicine at Mount Sinai and director of quality for cancer services at Mount Sinai Health System, who was approached for an independent comment. “They are thus likely not receiving quality care.” From a policy standpoint, in regard to the cost savings, it would be useful to look at new and innovative models to incorporate the use of transfusion. “That is something that we should really be strongly thinking about,” added Dr. Smith. - Cardinale Smith, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Geriatrics, Palliative Medicine, Icahn School of Medicine at Mount Sinai, Director, Quality for Cancer Services, Mount Sinai Health System Learn more: https://www.medscape.com/viewarticle/889858#vp_2

Medscape – December 13 Daratumumab Ready To Move To Front Line In Multiple Myeloma — Roxanne Nelson, RN, BSN The novel monoclonal antibody product daratumumab (Darzalex, Janssen) is already used for multiple myeloma in patients who have progressed on other therapies, but now it has been propelled to the front line. New results show that it also improves outcomes in patients with newly diagnosed multiple myeloma who are ineligible for transplant, when used in combination with triple therapy. "What is important about this study is that while daratumumab has been studied and approved for use in patients with relapsed/refractory multiple myeloma, this is the first study to look at it as a front-line agent in newly diagnosed patients," said Ajai Chari, MD, associate professor of medicine, hematology and medical oncology, director of clinical research in the Multiple Myeloma Program, associate director of clinical research at the Mount Sinai Cancer Clinical Trials Office at the Icahn School of Medicine at Mount Sinai. “We may be now looking at an alternative therapy for front-line treatment, in those who are ineligible for transplantation,” added. Dr. Chari. - Ajai Chari, MD, Associate Professor, Medicine, Hematology, Medical Oncology, Director, Clinical Research in the Multiple Myeloma Program, Associate Director, Clinical Research, Mount Sinai Cancer Clinical Trials Office, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/890021#vp_1

U.S. News & World Report – November 9 What To Know About The CIMAvax Lung Cancer Vaccine — Kathleen Hall Someday, we may have a vaccine that prevents all types of cancer, especially the more deadly types, like lung cancer. It’s an area of intense medical research. For now, there are only three cancer vaccines approved by the U.S. Food and Drug Administration. Researchers at Cuba's Center for Molecular Immunology developed a lung cancer vaccine called CIMAvax. Their studies showed that the vaccine was well-tolerated and that some patients seemed to do better after receiving it, said Jorge Gomez, MD, assistant professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai and medical director of the thoracic oncology program at Mount Sinai, who was not involved in the studies in Cuba. CIMAvax is a vaccine against a molecule called EGFR, Dr. Gomez said. EGFR is a normal molecule found on both healthy cells and lung cancer cells. It's also highly expressed in some patients with lung cancer. In these patients, EGFR is always turned on, so it continues to signal and promotes growth. About 15 percent of lung cancer patients, usually those who never smoked, have mutated EGFR. "Now we have drugs that work significantly better in this subset of lung cancer patients," Dr. Gomez said. - Jorge Gomez, MD, Assistant Professor of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Medical Director, Thoracic Oncology Program at Mount Sinai Learn more: https://health.usnews.com/health-care/patient-advice/articles/2017-11-09/what-to-know-about-the- cimavax-lung-cancer-vaccine

Gotham Gazette – January 3 High Rates Of Head Trauma In New York City Jails Raise Public Health, Recidivism Concerns — Maya Miller A new study finds that the rate of traumatic brain injuries (TBIs) sustained by inmates in New York City jails is more than 60 times higher than in surrounding communities. A head injury is considered a TBI if it causes the person to lose consciousness or to become confused and dazed. The new findings could help researchers better understand recidivism and the long-term mental health issues facing many individuals who are spending or have spent time in jail, since these injuries can lead to degenerative brain diseases. “Brain injuries are a chronic health condition that shorten and diminish quality of life,” said Wayne Gordon, PhD, professor and vice chair of rehabilitation medicine, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai, chief of rehabilitation psychology and neuropsychology at the Mount Sinai Hospital. “We need to be looking at how to make jails safer for these individuals, or it will continue to have significant public health implications.” Following a TBI, people commonly report an inability to concentrate and high levels of fatigue, among a host of other symptoms that have implications for recidivism rates and employment. - Wayne Gordon, PhD, Jack Nash Professor, Vice Chair, Rehabilitation Medicine, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief, Rehabilitation Psychology, Neuropsychology, The Mount Sinai Hospital Learn more: http://www.gothamgazette.com/city/7393-high-rates-of-head-trauma-in-new-york-city-jails-raise- public-health-recidivism-concerns

RevCycle Intelligence – January 2 Care Coordination, Community Health Workers Reduce ED Costs, Use — Jacqueline Belliveau Average direct emergency department costs dropped 15 percent for frequent emergency department users after Brigham and Women’s hospital implemented a care coordination program using community health workers, according to a recent study in the American Journal of Managed Care. Emergency department-based care coordination also resulted in eight percent less inpatient direct costs at the large urban academic center, reported researchers from the Icahn School of Medicine at Mount Sinai, Brigham and Women’s Hospital, and Harvard Medical School. “ED-based care coordination is a promising approach to reduce ED use and hospitalization among frequent ED users,” they wrote. “Our program also demonstrated a decrease in costs per patient. Future efforts to promote population health and control costs may benefit from incorporating similar programs into acute care delivery systems.” - Icahn School of Medicine at Mount Sinai Learn more: https://revcycleintelligence.com/news/care-coordination-community-health-workers-reduce-ed- costs-use

Managed Care Magazine – January 1 Who Pays To Care For The Seriously Ill? Maybe It’s Insurance Companies – Jan Greene Being diagnosed with a serious illness doesn’t just lead to doctors’ appointments and hospital stays; it can blow a hole in a person’s life that sends shock waves into the lives of friends and family, particularly their caregivers. America’s health care system, with its obsession with technology, has largely ignored the problems of very sick people that aren’t medical and even some that are, such as pain and the side effects of treatment. The fast- growing field of palliative care aims to reduce the suffering and improve quality of life for people with serious illness and assist their families. “When palliative care is done well, you’re spending a lot more time with patients and families than other clinicians do,” said Allison Silvers, director of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. Most urban hospitals now have palliative care teams and can cost-shift to maintain them if the reimbursement doesn’t pencil out. Palliative care is less available in rural parts of the country and in outpatient settings; outpatient clinics do exist but are available to a small percentage of those who need them. Even with these initiatives in the works, palliative care is a new discipline that is still on an uphill climb to be understood by both referring physicians and policymakers who decide reimbursement. - Allison S. Silvers, Director, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.managedcaremag.com/archives/2018/1/who-pays-care-seriously-ill-maybe-it-s- insurance-companies

Reader’s Digest – January 3 12 Signs That You’re Borderline Diabetic — Tina Donvito Borderline diabetes could be one of the medical reasons you’re tired all the time. If you’re one of the 84 million Americans who have prediabetes, you may notice you’re not feeling up to your normal activity level. Among the silent diabetes signs you might be missing is weight loss. Although we associate blood sugar problems with being overweight, once you start becoming borderline diabetic you may actually drop pounds. Diabetes may also keep sugar in your food from reaching your cells. This might leave you “feeling hungry all the time,” said Deena Adimoolam, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. So if you’re eating more than usual and still losing weight, talk to your doctor. One of the clear signs you have high blood sugar is actually not seeing clearly. Dr. Adimoolam said that blurred vision is a prediabetic symptom to watch out for. - Deena Adimoolam, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/signs-youre-borderline-diabetic/

Moneyish – January 3 Former Smokers Give Tips To Quit Smoking For Good — Nicole Lyn Pesce Smokers are addicted to more than just nicotine. Research shows that people are just as hooked on the self- medicating uses of cigarettes for stress relief and weight control. The reason four out of five people who try quit smoking relapse again in six months is because they’re not just addicted to nicotine — otherwise, medications like Chantix and replacement products like the patch would be more successful. “Quitting smoking is probably the hardest thing you are ever going to do. I’d rather get people off crack,” said Louis DePalo, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. “The recidivism rate is huge because it’s not just the nicotine. If you really want to be successful, you have to look at everything that one stick is giving you, which is why a combination of nicotine replacement and cognitive behavioral therapy has shown the most success,” added Dr. DePalo. Medication plus counseling doubles a smoker’s chance of quitting, according to the U.S. Public Health Services. - Louis DePalo, MD, Professor, Medicine, Pulmonary, Critical Care, Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://moneyish.com/upgrade/former-smokers-tell-moneyish-their-tips-to-butting-out-cigarettes- for-good/

HealthDay – January 3 What’s Your Best Diet For 2018? Experts Rate Them — Dennis Thompson Your New Year's resolution diet should be based on a well-balanced eating plan that fits your lifestyle, rather than a weird fad replete with food restrictions. That's according to U.S. News & World Report's best diet rankings for 2018. The two diets that tied for the top spot -- the Mediterranean Diet and the DASH Diet -- fit that bill because they feature real food and reasonable, flexible guidelines, experts said. Both the DASH and Mediterranean diets allow people the flexibility to choose from a wide variety of healthy foods, so they can eat what best suits them, said Kelly Hogan, MS, RD, CDN, clinical nutrition and wellness manager at the Dubin Breast Center at the Mount Sinai Hospital. "The DASH and Mediterranean diets are not excluding any foods or food groups or restricting anything," Hogan said. "I think that's really important when it comes to how a normal person eats in general." The diets are also both backed by a lot of scientific data that show they can help people lose weight and avoid heart disease and diabetes. - Kelly Hogan, MS, RD, CDN, Clinical Nutrition and Wellness Manager, The Dubin Breast Center, The Mount Sinai Hospital Learn more: https://consumer.healthday.com/vitamins-and-nutrition-information-27/dieting-to-lose-weight- health-news-195/what-s-your-best-diet-for-2018-experts-rate-them-729831.html Additional coverage: US News & World Report https://health.usnews.com/health-care/articles/2018-01-03/whats-your-best-diet-for- 2018-experts-rate-them CBS News https://www.cbsnews.com/news/best-diet-plans-for-2018-mediterranean-dash-diets/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - January 4, 2018 Date: Thursday, January 04, 2018 12:43:38 PM Attachments: ATT00001.txt

In the News __ January 4, 2018

The New York Times – December 26 The High-Tech, Big-Footprint Cancer Center — Helene Stapinski The New York Proton Center, set to start taking patients in February 2019, is the first of its kind in the state, providing specialized radiation treatment for children with cancer, those suffering from head and neck cancers and other tumors that require pinpoint treatment to avoid damage to surrounding tissues and organs. Proton therapy, which generally costs twice as much as traditional radiation, requires a large investment – not just in technology but in real estate. The Proton Center is made up of a consortium of three of New York’s leading cancer treatment providers – Sloan Kettering, Mount Sinai Health System, and Montefiore Health System. Coming together to purchase and share the expensive equipment made the project financially viable. Though the treatment is more expensive for insurers, the cost savings comes in the long run, said Kenneth Rosenzweig, MD, professor and system chair of radiation oncology at the Icahn School of Medicine at Mount Sinai and part of the team working on the project. “If we can limit side effects and limit cancer coming back, it’s going to be a benefit, in quality of life and in the cost,” he said. People who have already undergone extensive radiation are prime candidates for proton treatment, since there’s a limited amount of radiation that a body can endure. - Kenneth Rosenzweig, MD, Professor, System Chair, Radiation Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2017/12/26/nyregion/the-high-tech-big-footprint-cancer- center.html?_r=0

Bionity – January 4 Zooming In On Protein To Prevent Kidney Stones Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Structural and Molecular Biology, researchers revealed atomic-level details of the protein that serves as a passageway for calcium across kidney cell membranes. The new study is the first to show molecular details of the essential kidney calcium channel, called TRPV5, in its closed form. The study also reveals how inhibitor molecules attach to and close the channel, leaving calcium stranded in the urine where it can form kidney stones. The researchers said that when performing cryo-electron microscopy, they shot electrons at frozen protein, which allowed them to take pictures of individual protein molecules. With these pictures and advanced computer software, they were able to create 3D models of these molecules. These 3D models have the potential to be so precise that they can actually see the atoms that make up the protein. The new research builds upon computations by Marta Filizola, PhD, professor of pharmacological sciences and neuroscience, and dean of the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The study also brought together other researchers from Case Western Reserve University, Icahn School of Medicine at Mount Sinai, Pfizer, and Rutgers University. - Marta Filizola, PhD, Professor, Pharmacological Sciences, Neuroscience, Dean, The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.bionity.com/en/news/1152719/zooming-in-on-protein-to-prevent-kidney- stones.html?WT.mc_id=ca0068

Asbestos.com – January 4 Research Pinpoints Libby Amphibole Disease — Tim Povtak A research team led by Raja Flores, MD, Steven and Anne Ames professor in thoracic surgery, director of the thoracic surgical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and system chair of thoracic surgery for the Mount Sinai Health System, has identified Libby amphibole asbestos disease for the first time as the puzzling killer that continues to threaten innocent victims exposed to one variety of asbestos. This progressive pulmonary disease involves lamellar pleural thickening that has a suffocating effect on the lungs. “It’s a process that kills people before cancer does, before lung cancer or mesothelioma,” Dr. Flores said. “It’s a different disease. And it’s killing more of these people than anything else.” The Journal of Occupational and Environmental Medicine published research in December. The Centers for Disease Control provided a research grant to fund it. “This is a new disease, which is why it was important to publish this paper. It’s the first study to really describe he syndrome of Libby amphibole,” Dr. Flores said. “It can rapidly progress to death, much quicker than others.” - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://www.asbestos.com/news/2018/01/04/libby-amphibole-asbestos-disease/

Healio – January 3 Minority Infants Born More Frequently In Hospitals With High Morbidity, Mortality Rates — Katherine Bortz Infants of black or Hispanic race/ethnicity born very prematurely are more likely to be born in hospitals with higher morbidity and mortality rates and, subsequently, have higher rates of adverse outcomes when compared with white infants, according to findings published in JAMA Pediatrics. “We knew that this was a trend regarding neonatal mortality, but researchers had not looked at serious morbidities,” said Elizabeth Howell, MD, MPP, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean of academic development and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai. “It is interesting because in the last 10 to 20 years, we have made strides in the quality of NICU care, which has really improved overall outcomes. In this setting of improvement, it was interesting to look at whether these old patterns of care are still true today.” Dr. Howell added, “I think this research raises awareness and reminds us that pregnant women should be discussing their status with their obstetrician and learn about the signs and symptoms of early labor. There are a number of important practices and medications that can be used within this setting that can improve outcomes for very premature babies.” - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/pediatrics/neonatal-medicine/news/online/%7B211311fd-59f2-46b8- abd1-ba237807ed77%7D/minority-infants-born-more-frequently-in-hospitals-with-high-morbidity- mortality-rates Additional coverage: Becker’s Leadership & Infection Control https://www.beckershospitalreview.com/quality/preterm- infants-health-outcomes-differ-by-race-study-finds.html News Medical & Life Sciences https://www.news-medical.net/news/20180104/Study-finds-differences-in- preterm-infant-morbidity-and-mortality-rates-among-New-York-City-hospitals.aspx Yahoo News https://uk.news.yahoo.com/race-may-matter-hospital-care-191519188.html

MedPage Today – January 3 Newer TAVR May Equalize Mortality Risk Between Sexes — Nicole Lou It's no longer clear that women have a survival advantage after transcatheter aortic valve replacement (TAVR) for aortic stenosis, with a trio of studies that together suggest parity with newer TAVR devices. This may have something to do with having less moderate/severe aortic insufficiency and lower cardiovascular mortality, according to a study published in JACC: Cardiovascular Interventions. Women with balloon-expandable rather than self-expanding valves seemed to have a marked survival advantage, though the researchers found no statistically significant interaction between the subgroups. "In the current report we show that 1-year incidence of the VARC-2 efficacy endpoint was almost one-half the previously reported rates in prior TAVR studies with primarily older-generation devices," according to Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy, director of interventional cardiovascular research and clinical trials and the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/pci/70268

UNTV News – January 4 Air Pollution Around Conception Tied To Birth Defects Exposure to fine particles in air pollution may be another factor that affects men’s sperm quality and their fertility, suggests researchers in Taiwan. Although the clinical effect may be small, the findings could be important from a public health perspective due to worldwide exposure to pollution. The kind of particle pollution can be found both indoors and outdoors and most often comes from vehicle exhaust, the burning of wood, crops, coal or heating oil, and from emissions given off by power plants and other industries. The primary finding of this study is a significant decrease in the percentage of sperm that are normally shaped with increasing air pollution, but the percentage of sperm that are morphologically normal is still very high, said Shanna Swan, PhD, professor of environmental medicine and public health, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. The change in sperm concentration is difficult to interpret, noted Dr. Swan, who wasn’t involved in the study. For one thing, the average sperm concentration in the participants was fairly low. “Strengths of the study are its large size, its use of cutting-edge estimates of air pollution and WHO semen analysis methods,” Dr. Swan added. Semen quality is significantly related to fertility, men with no or very few moving sperm cannot fertilize an egg, she noted. - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.untvweb.com/news/air-pollution-around-conception-tied-to-birth-defects/

American Council On Science & Health – January 3 Before Taking Icy Plunge, Just Know ‘Cold Shock’ Health Risks — Erik Lief Three days before human hoards rushed into the Atlantic from a Brooklyn shore on New Year’s Day, three sharks up north, in the same ocean off Cape Cod, wound up doing something that usually doesn’t happen – they froze to death. While these two events are only tangentially related, what binds them is a condition called “cold-shock,” which is what marine biologists believe likely killed the sharks. It’s also what doctors warn legions of temporarily-off-kilter, winter swimmers they’ll experience when taking the “Polar Bear Plunge,” a frigid, semi-naked event held annually on the first of the year at Coney Island. Luckily, none of the estimated several hundred plungers avoided the fate of those sharks. But these humans did voluntarily expose themselves to the – literally – breath-taking feeling when warm skin comes into contact with near-freezing water. That combination creates the involuntary response of inhaling a giant gasp of air. "This can be incredibly dangerous," said Joseph Herrera, DO, professor and system chair of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai, "since you have no control over how and when it happens, it could occur when you are underwater, causing you to take water into your lungs. Depending on how much water you inhale and how long it takes you to get back to the surface, you could end up drowning." - Joseph Herrera, DO, Professor and System Chair, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.acsh.org/news/2018/01/03/taking-icy-plunge-just-know-cold-shock-health-risks- 12355 Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/before-taking-icy-plunge-just-know-39cold- shock39-health-risks

The Malaysian Times – January 4 Does A Strong Immune System Ward Off Colds And Flu? — Karen Weintraub “What makes people sick is a combination of bad luck — exposures to viruses or other pathogens — and the state of their immune system,” said Talia Swartz, MD, PhD, assistant professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. ”Someone with a weakened immune system is likely to be more vulnerable to passing bugs than someone with a healthy one.” There are definitely different types of patients who are more resistant to infections or who have slower progression of infectious diseases based on certain immune features we recognize that make them have a stronger immune system. “Frequent hand washing is crucial for keeping bugs from entering the mouth, nose and eyes, where they can spread infections,” added Dr. Swartz. She also recommended annual flu shots to attempt to prevent flu or reduce its severity. Other vaccinations, like the new shingles one, which is now recommended for people 50 and older, are also a good idea to help the immune system. - Talia Swartz, MD, PhD, Assistant Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://www.themalaysiantimes.com.my/strong-immune-system-ward-off-colds-flu/

Huffington Post – January 3 This Is Your Body On Dry January — Ashley Davidson In recent years, Dry January has become increasingly popular, with more and more people accepting the challenge to go booze-free for the entire month. It’s turned into something of a movement, with millions of participants worldwide every year. Alcohol dehydrates not only your body, but also your skin, said Debra Jaliman, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. If you’re an excessive drinker, you can develop a zinc deficiency, which can cause a histamine reaction that leads to facial redness and flushing, or rosacea, Dr. Jaliman added. Research shows that alcohol consumption is linked to a higher risk of rosacea in women. During Dry January, you may start to notice your skin looks and feels better – but once you start drinking again, Dr. Jaliman said, alcohol will start to have a dehydrating effect within weeks. If and when you start to drink again, Dr. Jaliman suggested to drink clear liquor like vodka. “It won’t trigger rosacea,” she said. - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.huffingtonpost.com/entry/your-body-on-dry- january_us_5a4baf2be4b06d1621bb0b77

Gluten Free Living Magazine – January 3 Celiac Parents And Gluten-Eating Kids — Susan Cohen Celiac runs in families. Given the nature of the disease, parents might have questions about their children and eating gluten, especially introducing it. “We used to think there was some crucial window that, if you got gluten in, that you could kind of hold off or decrease your risk for developing celiac disease in an at-risk individual. But we’ve since learned that’s not really the case,” explained Jacqueline Jossen, MD, assistant professor of pediatrics and gastroenterology at the Icahn School of Medicine at Mount Sinai. “The general recommendation is to introduce gluten just as you would start introducing other foods to babies between four and six months of age.” When it comes to eating gluten, “regardless of whether or not they have the gene for celiac, unless they have celiac disease there’s really no reason to adjust their diet,” noted Dr. Jossen. Beyond it not being medically necessary for a child without celiac to be on a gluten-free diet, there is a big nutritional reason. “The gluten-free foods are really much higher in fat and sugar and much lower in fiber and enriched grains than the gluten-containing counterparts,” explained Dr. Jossen. - Jacqueline Jossen, MD, Assistant Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://www.glutenfreeliving.com/gluten-free-lifestyle/kids/celiac-parents-gluten-eating- kids/

CheatSheet – January 4 Surprising Anti-Aging Secrets From A Top Dermatologist — Jessie Quinn Whether you have mature skin and are looking to reduce the look of wrinkles, dark spots, and other signs of aging, or you’re trying to prolong youthful skin, everyone can benefit from an anti-aging skin care routine. When it comes to aging skin, exfoliation is key, said Debra Jaliman, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. That said, Dr. Jaliman suggested exfoliating the skin with a washcloth in gently rubbing motions. That way, you get the benefits of skin exfoliation with irritating or damaging your complexion. Another important anti-aging secret everyone should follow is cleansing. “It’s important to wash well when we come from outside to remove dirt of pollution from the skin’s surface,” added Dr. Jaliman. Pollution is full of skin-aging free radicals, so cleansing the skin is an absolute must. The most important anti-aging skin care product is sunscreen. Specifically, a broad-spectrum sunscreen that “protects against both UVA rays that penetrate deeply into the skin, as well as UVB rays, which are burning rays,” said Dr. Jaliman. “Sun damage is cumulative – even ten minutes of exposure a day over the course of a lifetime is enough to cause major problems,” she added. - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.cheatsheet.com/gear-style/anti-aging-secrets-top-dermatologist.html/?a=viewall

Men’s Health – January 3 Why You Get Puffy, Dark Circles Under Your Eyes When You’re Tired — Suzannah Weiss Most of us have noticed dark circles under our eyes after a bad night’s sleep. But why do they show up, and what can you do about them? What you’re seeing is actually dilated blood vessels under the skin around your eyes, said Debra Jaliman, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. Sometimes, the tissue under your eyes will swell with fluid, making them seem puffy, too. Dr. Jaliman says these dilated blood vessels should go away after a good night’s sleep— ideally seven or eight hours. In the meantime, coffee is your friend for more than one reason: In addition to waking you up, it makes blood vessels constrict. And when blood vessels are smaller, they're less noticeable, meaning no more darker circles. Other fixes include putting gel ice packs, tea bags, or cucumber slices on your eyes and taking an over-the-counter antihistamine like Benadryl. - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.menshealth.com/health/causes-of-dark-circles-under-eyes

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 5, 2018 Date: Friday, January 05, 2018 1:18:43 PM Attachments: ATT00001.txt

In the News January 5, 2018

The Scientist – January 5 New Initiatives Offer Jobs, Funding To Women Only — Ashley Yeager For years, universities and funding organizations have attempted to address women’s underrepresentation among science faculty, whether by removing barriers to recruitment and retention or trying to dispel biases among employers and grant makers. Two newly announced programs take the less common, more contentious approach of affirmative action – offering positions or funding specifically for female investigators. While studies of US National Institutes of Health awards show mixed results when it comes to funding female versus male PIs, the organization recognizes there are differences based on sex in awarding grants. Sandra Masur, PhD, director of the Office for Women’s Careers at the Icahn School of Medicine at Mount Sinai, also noted that studies indicate that “women take longer at each step of the ladder on the way to leadership, so just bringing in more women without addressing the timeline may not make a difference in retaining the best women scientists at the Max Planck.” When Dennis Charney, MD, became dean of the Icahn School of Medicine at Mount Sinai in 2007, he noticed there were no women chairs, academic deans, or institute directors. “This struck me as something that had to be fixed,” Dr. Charney said. As of 2017, there were six female chairs, six female institute directors, and four female deans, which Dr. Charney sought out and appointed over time as positions became available. One key to fixing the existing inequalities in science is making department members aware of them. - Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System - Sandra K. Masur, PhD, Professor, Ophthalmology, Pharmacological Sciences, Director, Office for Women’s Careers, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/51256/title/New-Initiatives-Offer-Jobs--Funding-to-Women-Only/

CBS News – January 4 Combat Veterans Suffering From Same Brain Disease As Concussion Victims – Sharyn Alfonsi They did not lose limbs, but many veterans exposed to blasts in combat will eventually lose their minds. Just like athletes who endured repeated blows to the head, veterans are suffering from the same degenerative brain disease. The effects on the brain are not readily seen on images, that has been what everyone calls an invisible injury. Samuel Gandy, MD, PhD, professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai, is hoping to change that. He is using new technology to find the markers of CTE in the living in order to inform those who may have the disease and help find a way to stop its deadly progress. These images will be crucial in his work with drug companies to find a treatment. Sharyn Alfonsi reports on the chronic traumatic encephalopathy and its impact on combat veterans on the next edition of 60 minutes, Sunday, January 7th at 7:00pm. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.cbsnews.com/news/combat-veterans-suffering-from-same-brain-disease-as-concussion-victims/

Healthcare Finance News – January 4 Mount Sinai: Racial Disparities ‘Manifest In Morbidities’ Among Patients — Beth Jones Sanborn A new study by researchers at the Icahn School of Medicine at Mount Sinai is shining a light on the role hospital quality can play in mortality and morbidity for “very preterm births,” as well as racial disparities in the rate of VPTBs that seem to point the finger at where the baby is born. A team of researchers led by Elizabeth Howell, MD, MPP, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean of academic development and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai, examined data related to 7,177 very preterm births at 39 New York City hospitals. That means births that occurred at 24 to 31 weeks gestation. Researchers found that morbidity and mortality occurred in 28 percent of those births. They also found that was higher among African-American and Hispanic VPTBs. “This makes us think about how those disparities manifest in morbidities as well as the possibility that quality of care can influence these outcomes. You’re setting a trajectory of cost and extra resources for throughout that person’s life,” Dr. Howell said. “Quality of care is something that should be looked at, at any hospital seeing high morbidity and mortality rates in these vulnerable patients, whether it’s New York City hospitals or some other city.” - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.healthcarefinancenews.com/news/mount-sinai-racial-disparities-manifest-morbidities-among-patients

Medscape – January 3 Immune Cells Linked To Very Early Spread Of Breast Cancer — Marilynn Larkin Normal immune cells that live near milk ducts in healthy breast tissue may play a key role in helping early breast cancer cells leave the breast for other parts of the body, researchers say. This could possibly cause cancer to metastasize, or spread, even before a tumor has developed, according to Julio Aguirre-Ghiso, PhD, professor of medicine, hematology, medical oncology, otolaryngology, and oncological sciences at the Icahn School of Medicine at Mount Sinai. The study was published in Nature Communications. In the current study, the team reports that immune cells called macrophages play an important role in this process. Working in mice and in human cells in the laboratory, the team found that dissemination occurs when macrophages are attracted to the milk ducts, where they trigger a chain reaction that enables the early cancer cells to leave the breast. “We show that by disrupting this process, we can prevent early dissemination and, ultimately, deadly metastasis” explained Dr. Aguirre-Ghiso. “Our study challenges the dogma that early diagnosis and treatment means sure cure.” It could also be a starting point for a test that could identify patients with the earliest form of breast cancer, known as ductal cell carcinoma in situ, which may already have disseminated disease, he suggested. - Julio Aguirre-Ghiso, PhD, Professor, Medicine, Hematology, Medical Oncology, Otolaryngology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/890778 Additional coverage: Deccan Chronicle https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/030118/immune-cells-help-early-breast-cancer-cells- spread-through-the-body-study.html Channel News Asia https://www.channelnewsasia.com/news/health/immune-cells-linked-to-very-early-spread-of-breast-cancer-9827466

Infectious Disease Advisor – January 5 Universal Flu Vaccine: A Game Changer In Prevention— Jasenka Piljac Zegarac, PhD Influenza is a significant cause of global morbidity and mortality due to viral infections. The Centers for Disease Control and Prevention estimated the number of influenza-associated deaths in the United States to range between 12,000 and 56,000 in the period between the 2010/2011 and 2013/2014 influenza seasons. With the aim of overcoming the shortcomings of currently available influenza vaccines, researchers led by experts from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health embarked on a quest to develop a universal influenza vaccine. Florian Krammer, PhD, associate professor of microbiology at the Icahn School of Medicine at Mount Sinai said, “Universal influenza vaccines need to target the conserved parts of the virus that do not change much over time. Currently, the conserved stem domain of the HA is the main target.” Dr. Krammer added, “A vaccine that has to be given only two to three times in a lifetime will be much better accepted than a vaccine that has to be given every year, so it is likely that vaccination rates would reach a very high level. In addition, the current vaccines are not included in childhood vaccination programs in low and middle income countries, because it is too expensive and complicated to give them every year.” - Florian Krammer, PhD, Associate Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: http://www.infectiousdiseaseadvisor.com/influenza/universal-influenza-vaccine/article/734748/

Devex – January 3 Opinion: Africa Needs Investment In Palliative Care — John Ree and Dr. Emmanuel Luyirika Palliative care services are seriously lacking in Africa. Nineteen percent of African countries do not have identified palliative services and 71 percent of the services that do exist are concentrated in Uganda, South Africa, and Kenya. The HIV epidemic played a driving role in developing palliative care services and resources in many countries in Africa, with initial funding in HIV helping to boost hospices and palliative care services on the continent. New research, supported by the Arnhold Institute for Global Health at the Icahn School of Medicine at Mount Sinai, shows that while palliative care developed rapidly in South Africa through funding available for HIV, the proliferation of earmarked funds for hospices mean programs are often only allowed to care for patients with HIV that had palliative needs. Lead researcher, John Rhee, a fourth year medical student at the Icahn School of Medicine at Mount Sinai, said “Due to this shifting landscape and overall decreases in funding, governments in Africa will need to increase the share of funding for palliative care. Not doing so will result in millions dying with minimal-to-no access to palliative care and pain management.” - John Y. Rhee, Fourth Year Medical Student, Icahn School of Medicine at Mount Sinai - Arnhold Institute of Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.devex.com/news/opinion-africa-needs-investment-in-palliative-care-91818

New York Post – January 4 Why You Don’t Need AA To Quit Drinking — Lauren Steussy Although doctors still don’t know much about why people get addicted or how to prevent it, they do see a clear genetic linkage; it’s often that problems arise, not due to lack of willpower, but rather because of the traits people inherit when they’re born. “When I talk to patients about genetic predisposition, it does wonders because it allows them to conceive of their illness as a medical problem that they didn’t choose, and then they can start focusing on their treatment,” said Tim Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the fellowship in addition medicine program at the addiction institute at Mount Sinai West. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://nypost.com/2018/01/04/why-you-dont-need-aa-to-quit-drinking/

WebMD – January 4 Good News, Parents: Teens Are Delaying Having Sex— Dennis Thompson Fewer U.S. teens are sexually active these days, as many wait until later in high school to try sex for the first time, a new report reveals. The proportion of high school students who’ve ever had sex decreased to 41 percent in 2015, continuing a downward trend from 47 percent in 2005 and 53 percent in 1995, according to data from the U.S. Centers for Disease Control and Prevention. Matthew Oransky, PhD, assistant professor of pediatrics, adolescent medicine, and psychiatry at the Icahn School of Medicine at Mount Sinai and director of the psychology training program at the Mount Sinai Adolescent Health Center said, “what seems really promising about this is that the older you get, the better ability you have to make decisions and communicate and plan. The older you are when you initiate sex, the better able you will be to make healthy and responsible decisions.” Health experts suggested that sex education is most likely explanation for the trend. Dr. Oransky added that a cultural shift also might be at play, where adults are more comfortable having frank discussions with teenagers about sex. “It’s a big focus at our center, recognizing that – whether or not we like it – adolescents are making these decisions,” Dr. Oransky said. “We have to arm them with knowledge to make the decision that’s most comfortable for them and best for their future.” - Matthew Oransky, PhD, Assistant Professor, Pediatrics, Adolescent Medicine, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Psychology Training Program, Mount Sinai Adolescent Health Center Learn more: https://teens.webmd.com/news/20180104/good-news-parents-teens-are-delaying-having-sex#1 Additional coverage: The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay729906_20180104_Good_New_for_Parents__Teens_Are_Delaying_Having_Sex.html? mobi=true

MedPage Today – January 4 2018: What’s Next In Infectious Diseases? — Molly Walker Antibiotics, opioids, and influenza were top-of-mind as experts in infectious diseases looked towards what will be the biggest issue in their field in 2018. The FDA has taken some steps to address antibiotic resistance, with the recent launch of a website designed to help physicians manage their antibiotic prescribing. But supply, not just resistance, may also be a problem, as Judith Aberg, MD, professor of medicine, infectious disease and chief of the division of infectious diseases and immunology at the Icahn School of Medicine at Mount Sinai, pointed out. "We are continuing to experience significant national shortages of antibiotics as well as the saline necessary to infuse antibiotics, which will continue to pose challenges to manage potentially serious infections," she said. - Judith Aberg, MD, Dr. George Baehr Professor, Medicine, Infectious Disease, Chief, Division of Infectious Diseases and Immunology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/70300

Cheat Sheet – January 5 What You Don’t Know About Melasma, A Skin Condition That’s More Common Than You Think— Jessie Quinn When it comes to skin care, hormones can be our worst nightmare. Whether it’s acne in our teens or the effect of menopause, it seems like hormones lash out on our skin in the worst of ways throughout every stage of our lives. According to the American Academy of Dermatology, melasma is a common skin condition that causes brown to gray-brown patches, usually on the face. Also called the “mask of pregnancy,” melasma can occur in up to 50 percent of pregnant women. “Because of pregnancy hormones, the skin is more sensitive to sunlight,” said Debra Jaliman, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai. “It can also occur because of birth control pills, sometimes there is no obvious cause.” While anyone can get it, women are most prone to it. According to Dr. Jaliman, women with dark skin, dark hair, and dark eyes are most susceptible. “The more melanin you have, the more likely you will get melasma.” Whether its pregnancy hormones or added hormones from birth control, melasma is typically a side effect of added hormones. When caring for melasma-ridden skin, sun care is a must. Because the sun’s UV rays can darken the look of melasma, “it is important to use broad-spectrum SPF 30 sunscreen every single day, rain or shine,” Dr. Jaliman said. - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.cheatsheet.com/gear-style/what-is-melasma.html/?a=viewall

Kaplan Herald – January 4 Winter Pores And Skin: Defend It From Chilly, Dry Climate In summer, you probably know you need to use sunscreen. But did you know there are steps you should take to protect your skin in the winter as well? Cold and dry weather can turn skin coarse, irritated, and lead to premature aging. This situation is made worse by going out in the cold and the coming back to an overheated house indoors; creating dehydrating conditions that can dry out even the most resilient skin. “As the temperature falls, the air loses its humidity, resulting in skin problems like itching, cracking, and discomfort,” said Janet Prystowsky, MD, PhD, associate clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. These problems become even worse as you grow older, she added. The reason for this problem, Dr. Prystowsky said, is a substance known as sebum. Our body’s sebaceous glands, located near our hair follicles, secret sebum, a light, oily substance that keeps our skin and hair moisturized. As we age, our body’s production of sebum diminishes, she said. In the winter, your number one skin care goal should be to preserve all of the moisture you have in your skin. - Janet H. Prystowsky, MD, PhD, Associate Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://kaplanherald.com/2018/01/04/winter-pores-and-skin-defend-it-from-chilly-dry-climate/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 8, 2018 Date: Monday, January 08, 2018 12:56:44 PM Attachments: ATT00001.txt

In the News __ January 8, 2018

CBS News: 60 Minutes – January 7 Scientists Seek Veterans For Final Act Of Service — Brit McCandless Farmer Anxiety, irritability, memory loss, cognitive problems, profound depression – often to the point of suicide – these have been the unwelcome symptoms ushering the return home for thousands of veterans since 9/11. In that time, more than 300,000 service members have been given a diagnosis of traumatic brain injury, but scientists are now learning that some of those injuries are much more severe than they initially thought. Some veterans’ brains are affected by chronic traumatic encephalopathy, or CTE, caused by repeated blows to the head. There’s currently no cure for CTE, a debilitating brain disease that causes symptoms such as depression, memory loss, difficulty thinking, and impulse control. Researchers are trying to find ways to treat – and even just diagnose – CTE, and for that, they need veterans. While the only fool-proof way to diagnose CTE is by testing a post-mortem brain, Samuel Gandy, MD, PhD, professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai, is using scans that test for the disease in the living. In Dr. Gandy’s trial, participants are injected with the tracer, and then put through a 20 minute PET scan. High resolution images of their brains are combined with MRI results to get a 360-degree picture, showing whether there are signs of CTE. In the past year, 36 veterans and athletes have been tested for the disease in Dr. Gandy’s lab. He hopes his trial will lead to drug therapies that offer relief to future CTE patients – and maybe even to a cure. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.cbsnews.com/news/scientists-seek-veterans-for-final-act-of-service/ Additional coverage: The Columbus Dispatch http://www.dispatch.com/news/20180107/cambridge-veteran-and-wife-appear- on-60-minutes MedicalHealthNews.net http://www.medicalhealthnews.net/combat-veterans-coming-home-with-cte

Politico New York – November 30 Making Rounds — Dan Goldberg The Icahn School of Medicine at Mount Sinai and Institut Pasteur announced they are forming the Artificial Virus Evolution Unit, a joint research unit to study viral pathogens. - Icahn School of Medicine at Mount Sinai Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2017/11/30/vullo-sues-feds-for-575-million-012227

MedPage Today – January 7 What Will 2018 Hold For Endocrinology? — Kristen Monaco In thyroid disorders, last year’s theme was to “do less,” said Terry F. Davies, MD, co-director of the thyroid center at Mount Sinai Union Square and professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. “This is the most obvious where the treatment of early and small thyroid cancers are concerned. Watchful waiting has been used in Japan for many years rather than rushing to have the thyroid removed and then dosing with radioiodine. Now we are beginning to practice in the same way. Furthermore, our use of radioactive iodine has been markedly reduced in many thyroid cancer patients where the tumor is confined and not causing problems as assessed at surgery,” said Dr. Davies. - Terry F. Davies, MD, FRCP, Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Co- Director, The Thyroid Center, Mount Sinai Union Square Learn more: https://www.medpagetoday.com/endocrinology/generalendocrinology/70321

Kaplan Herald – January 5 Are We Reaching The Top Of The Opioid Epidemic? The opioid epidemic claimed the lives of more than 63,000 Americans in 2016. If we are to call the rampant drug abuse and overdoses an ‘epidemic,’ then research suggests it may actually be past its peak, and the slowdown that is already occurring will continue, regardless of new federal proclamations. President Trump’s newly-established opioid commission made an exhaustive list of over 50 recommendations for addressing the public health emergency. Drug addiction needs to be destigmatized, but prevention campaigns like ‘DARE’ may not help, experts worry. The public information campaign is necessary, but in itself would not be sufficient. Tim Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the fellowship in addiction medicine program at the Addiction Institute at Mount Sinai West, is in favor of efforts to destigmatize addiction in order to encourage people to seek treatment, he said that campaigns like the Drug Abuse Resistance Education effort of the 1980s and 1990s are misguided. “Destigmatization is wonderful, especially because what we see in the opioid crisis has a lot of parallels to the HIV/AIDs crisis,” said Dr. Brennan. He said that fear kept people from getting tested and treated for HIV, but once it was longer seen as a disease of the marginalized, diagnoses and preventative measures increased and its spread lowered. “If we could do that for opioid disorder, that’d be wonderful, because a lot of people are scared to tell their families or anyone else about their addictions,” Dr. Brennan added. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://kaplanherald.com/2018/01/05/are-we-reaching-the-top-of-the-opioid-epidemic/

Forbes – January 7 Want To Boost Your Career? Go To A Museum — Benjamin Wolff The Academy for Medicine and Humanities, formed in 2012 as part of the department of medical education at the Icahn School of Medicine at Mount Sinai, incorporates music, writing, philosophy, and visual art into the standard medical school curriculum. While most of the courses are elective, those students who embrace what other disciplines can teach them about medicine also advance their careers in striking ways. Barry S. Coller, MD, clinical professor of medicine at the Icahn School of Medicine at Mount Sinai said that active participants in the Academy graduate in the top 20 percent of their class, and go on to be chief residents and leaders in their medical specialties. - The Academy for Medicine and Humanities, Department of Medical Education, Icahn School of Medicine at Mount Sinai - Barry S. Coller, MD, Clinical Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.forbes.com/sites/benjaminwolff/2018/01/07/want-to-boost-your-career-go-to-a- museum/#5d64de557d99

PopSugar – January 8 Your 2-Week Sugar Detox — Michael De Medeiros Millions of Americans have a weight problem. One study predicts that more than 85 percent of adults will be overweight or obese by the year 2030. The culprit? Sugar. Added sugars and refined carbohydrates both have the same negative impacts on our bodies. Studies are finding that sugar consumption is liked to chronic diseases such as type 2 diabetes, heart, disease, liver disease, and depression. In a study, Nicole Avena, PhD, assistant professor of pharmacological sciences at the Icahn School of Medicine at Mount Sinai lists uncontrollable cravings for pizza and chocolate as “big offenders” Dr. Avena attested that these foods “share pharmacokinetic properties with drugs of abuse.” Some other signs that you consume too much sugar are if you eat sugary, refined, processed foods even if you aren’t truly hungry, you feel bloated and overly full due to overeating, and you are hungry for the same junk food in a short period of time after eating. Doctors suggest that you treat unhealthy eating patterns just as you would any type of addiction and quit sugar cold turkey. - Nicole Avena, PhD, Assistant Professor, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.popsugar.com/fitness/Two-Week-Sugar-Detox-44271478

Moneyish – January 5 These Simple Exercises Can Make Your Face Look Three Years Younger — Nicole Lyn Pesce A new Northwestern University study claims that doing facial exercises for five months can make you look three years younger. This concept of exercising your face has been recently taking shape with movements like Face Yoga and FaceXercise, which reportedly help maintain the elasticity and firmness of the skin on your face. But don’t expect facial exercises to replace fillers and actual facials just yet. Andrew Alexis, MD, MPH, associate professor of dermatology at the Icahn School of Medicine at Mount Sinai and site chair of the department of dermatology at Mount Sinai St. Luke’s and Mount Sinai West, warned that practicing repetitive movements around your mouth and forehead can actually create more wrinkles. “It’s important to note that the study strengthened the muscles of the mid-face by doing specific maneuvers that would strengthen those muscles and provide greater support for the fat pads and the skin that overlies the muscles – but exercising the muscles of the forehead and in between the eyebrows could actually make the face look aged,” said Dr. Alexis. - Andrew Alexis, MD, MPH, Associate Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Skin of Color Center at Mount Sinai, Site Chair, Department of Dermatology, Mount Sinai St. Luke’s-Mount Sinai West Learn more: https://moneyish.com/upgrade/these-simple-exercises-make-your-face-look-three-years- younger/

Daily Beast – January 5 Is Drinking Collagen Really The Key To Eternal Youth? — Lizzie Crocker While beauty supplements make up a relatively small percentage of the United States’ vitamin and supplement market, the beauty sector is growing rapidly. In its 2016 Consumer Survey on Dietary Supplements, the Washington D.C.-based Council for Responsible Nutrition found that nearly one-fifth of the people who take supplements in the U.S. take them for skin, hair, and nail benefits. And collagen- infused drinks and powders are leading the craze. The idea that collagen supplements can improve gut health and kick start collagen production is seductive, but not everyone is buying it. One issue is that collagen will be broken down into component amino acids in the digestive process. “It’s possible that these amino acids could be absorbed into the bloodstream and make their way to the skin,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. “If collagen supplements do in fact provide a benefit to our skin, it is likely because of their ability to provide amino acid building block for new collagen production by our skin cells,” Dr. Zeichner added. But, he said, there’s no scientific evidence supporting the alleged health and beauty benefits of ingestible or topical collagen. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.thedailybeast.com/is-drinking-collagen-really-the-key-to-eternal-youth

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 9, 2018 Date: Tuesday, January 09, 2018 1:12:39 PM Attachments: ATT00001.txt

In the News January 9, 2018

Crain’s Health Pulse – January 9 Who's News Helen Mayberg, MD, a behavioral neurologist who studies brain circuits in depression and has pioneered deep brain stimulation research, has joined the Mount Sinai Health System as the founding director of The Center for Advanced Circuit Therapeutics. She was previously professor of psychiatry, neurology and radiology and held the inaugural Dorothy C. Fuqua chair in psychiatric neuroimaging and therapeutics at Emory University School of Medicine. - Helen Mayberg, MD, Senior Faculty, Neurosurgery, Neurology, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, Director, The Center for Advanced Circuit Therapeutics, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180109/PULSE/180109931/archcare-at-home-to- close-its-long-island-offices (Subscription required) Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/09/guardians-debate-022790

Huffington Post – January 9 How To Choose The Best Health App For You — Ashish Atreja, MD, MPH Improving your health is always a popular New Year’s resolution. Today, digital tools are widely available to help us keep this resolution. The array of options is dizzying, with 318,000 health-related apps available for your smartphone or tablet, covering nearly every type of disease, and virtually any health and wellness topic, from meditation to smoking cessation. Ashish Atreja, MD, MPH, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai, director of the Sinai AppLab, and chief technology, innovation and engagement officer at the Mount Sinai Hospital said that not all apps are created equal in delivering high quality and meaningful results. There are some strategies to help you tell the good from the bad. “Some health apps may make false, exaggerated, or unproven claims. Look for those backed by scientific evidence supporting their use. If you feel overwhelmed by the number of similar apps, ask your doctor if he or she can recommend one,” said Dr. Atreja. Apps can be a valuable tool for building a path toward better health through better knowledge, health tracking, and data exchange. - Ashish Atreja, MD, MPH, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Sinai AppLab, Chief Technology, Innovation and Engagement Officer, The Mount Sinai Hospital Learn more: https://www.huffingtonpost.com/entry/how-to-choose-the-best-health-app-for- you_us_5a54d736e4b0ee59d41c0e01

Healthline – January 4 Opioid Addiction Treatments That May Surface In 2018 — Kristen Fischer In 2016 alone, more than 63,000 people died from drug overdoses. More than 42,000 of them were opioid- related death, according to the National Center for Health Statistics. A study published in the journal Cell concludes that it’s possible to create pain-relieving opioids that don’t cause side effects. While 12-step programs can work effectively to treat alcohol use disorder, that’s not the case for people addicted to opioids. The country must prevent people from being addicted, which requires being more cautious in prescribing opioids. Buprenorphine remains the best treatment for opioid addiction. It’ll soon be available as a monthly injection so people don’t have to remember to take a pill daily. Along with buprenorphine, other FDA-approved options for treating opioid addiction include methadone and naltrexone. They’ve been tested extensively for effectiveness and safety, said Edwin Salsitz, MD, assistant clinical professor of psychiatry at the Icahn School of Medicine at Mount Sinai and addiction specialist at Mount Sinai Beth Israel. “Generally the medications are combined with psychosocial treatments to provide the optimal outcomes,” Dr. Salsitz said. Methadone maintenance is helpful for people who don’t do well with buprenorphine. But people have to visit a clinic daily to receive that treatment. - Edwin Salsitz, MD, Assistant Clinical Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Addiction Specialist, Mount Sinai Beth Israel Learn more: https://www.healthline.com/health-news/opioid-addiction-treatments-surface-in- 2018#modal-close

CNBC News – January 9 Get Ready, Some Medical Experts Are Predicting The Worst Flu Season In History —Bob Woods Medical experts in the United States are worried that this year’s flu season could be a nasty one that may be lethal. That’s because this year’s main flu strain, the influenza A virus, known as H3N2, is worse than the swine flu in 2009. This year’s H3N2 sickened over 215,000 as the illness has hit our shores. Its’ a situation that has led the Centers for Disease Control and Prevention to do a collaborative study with global health partners in an effort to make addressing the situation a global priority. The definition of a universal flu vaccine is somewhat flexible. Ideally, a single injection would protect against all known and emerging influenza A strains and last a lifetime, said Peter Palese, PhD, professor and chair of microbiology, professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. More modest proposals envision a one-shot vaccine that would protect against getting the flu for anyone from three to 20 years. Dr. Palese’s laboratory is one of three different research groups at Mount Sinai exploring a universal flu vaccine and one of numerous efforts under way mostly in academia, biotech firms, and NIH. Dr. Palese’s team has developed a universal flu vaccine that is now in the first phase of testing in humans. “What changes in the influenza virus from year to year is the hemagglutinin, which is the major protein against which we make an immune response,” said Dr. Palese. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnbc.com/2018/01/09/medical-experts-predict-worst-flu-season-in-history.html Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/get-ready-some-bmedicalb-experts-are- predicting-the-worst-flu-season-in-history

U.S. News & World Report – January 8 #MeToo Goes To School — Lauren Camera Nearly half of students in grades seven to 12 – and more than half of girls overall at that level – reported experiencing some form of sexual harassment in the 2010-2011 school year, according to research from the American Association of University Women. This is not an issue that’s only regulated to college campuses or other workplaces. It’s something that’s happening early in our students’ lives, and there is a real imperative for us to do something about it. The problem, however, is masked by rampant underreporting – by students themselves and by schools and school districts – which results in the public often overlooking the epidemic entirely at the K-12 level. Linda E. Olszewski, PsyD, assistant professor of pediatrics, adolescent medicine, and psychiatry at the Icahn School of Medicine at Mount Sinai, said only about nine percent of sexually abused teenagers ask for help, and it’s usually not from a teacher or other adult. “What we see here are the kids who are actually asking for help,” she said of the cases she and her team handle, which include many instances of social media harassment. “We see the brave kids and those asking for the helping hand,” she added. She said she is starting to see an uptick in students seeking help, and that campaigns like #MeTooK12 are helping shine a light on the issue. - Linda E. Olszewski, PsyD, Assistant Professor, Pediatrics, Adolescent Medicine, Psychiatry, Mount Sinai Adolescent Health Center, Icahn School of Medicine at Mount Sinai Learn more: https://www.usnews.com/news/education-news/articles/2018-01-08/the-metoo-movement- goes-to-school

WCAX News – January 8 FDA Approves Device To Diagnose Strokes – Nikki Battiste Stroke is a leading cause of disability in the United States, according to the American Stroke Association. A new device to quickly diagnose cases of severe stroke has just received the green light from the FDA. The Cerebrotech Visor transmits low-power radio waves through the brain looking for changes in blood flow. It takes just 30 seconds to analyze the fluids. “The big thing about a stroke is that there’s asymmetry when one of the arteries feeding one side of the brain is blocked compared to the other side. So, we can detect that with this visor,” said Christopher Kellner, MD, director of the intracerebral hemorrhage program at Mount Sinai and assistant professor of neurosurgery at the Icahn School of Medicine at Mount Sinai. Dr. Kellner said the goal of the visor technology is to help quickly identify patients who have had a severe stroke so they can receive immediate treatment. “Time is brain. As someone is having a stroke, they’re losing many, many neurons every second. And so anytime we can decrease from that is very important,” he added. - Christopher P. Kellner, MD, Director, Intracerebral Hemorrhage Program at Mount Sinai, Assistant Professor, Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.wcax.com/content/news/FDA-approves-device-to-diagnose-strokes- 468339403.html Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/new-stroke-visor-can-detect-sign-of-strokes- in-less-than-1-minute

GenomeWeb – January 8 Startup Pillar Health Aims To Marry Consumer Genomics, Wellness — Monica Heger New York City-based startup Pillar Health, launched last week, aims to tap into the growing consumer genomics space with initial products in wellness. Pillar was founded by genomics researchers Joel Dudley, PhD, director of the Next Generation Healthcare Institute at the Icahn School of Medicine at Mount Sinai, and Christopher Mason, an associate professor at Weill Cornell Medicine. Pillar plans to offer a full suite of omics analyses to consumers, including genomics, epigenomics, metabolomics, and microbiomics to consumers and will pair those analyses with an assessment of the individual's built environment in order to identify markers of wellness and health. - Joel Dudley, PhD, Director, Next Generation Healthcare Institute, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/sequencing/startup-pillar-health-aims-marry-consumer- genomics-wellness

MD Magazine – January 8 Sean Ianchulev, MD, MPH: Microinterventional Cataract Fragmentation — Jenna Payesko Microinterventional lens and cataract fragmentation technology is something that was introduced earlier this year in the United States, and it uses microinterventional thin filaments, super-elastic technology, something that is used commonly in interventional radiology and also cardiology that allows you to use those very thin filaments to go around the lens and then fragment the lens into pieces. Sean Ianchulev, MD, MPH, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and director of the ophthalmic innovation and technology program at the New York Eye and Ear Infirmary of Mount Sinai, discussed the benefit of using microinterventional fragmentation of the lens instead of phacoemulsification to aid in cataract surgery. The breakthrough technology, miLOOP, will change how cataract surgery is performed and how doctors fragment the lens, exposing the eye to less surgery. - Sean Ianchulev, MD, MPH, Professor of Ophthalmology, Icahn School of Medicine at Mount Sinai, Director of the Ophthalmic Innovation and Technology Program, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.mdmag.com/medical-news/sean-ianchulev-md-mph-microinterventional- cataract-fragmentation

Women’s Health Magazine – January 8 How Much Canned Food Is Really Safe For You To Eat? — Colleen De Bellefonds Odds are, if you opened your kitchen cabinets right now, you’d probably find some kind of canned foods in there – and there’s a good reason why we all stock up – canned foods are a stable for meal prep and cheap cooking. Although it might seem like canned foods have less nutrients than their fresh counterparts, the canning process doesn’t affect foods’ protein, carbohydrate, and fat content, or the amount of minerals and fat-soluble vitamins. But because canning involves high heat, some water-soluble vitamins can be damaged – although losses vary from food to food. That said, there are some risks that come with consuming canned foods. The greatest concern is about BPA exposure during pregnancy. “In humans, BPA exposure when the fetus is developing may increase the risk for behavior issues, like hyperactivity and aggression, later breast development during puberty, obesity, diabetes, heart disease, and changes in liver function,” said Maida Galvez, MD, MPH, associate professor of preventive medicine and pediatrics at the Icahn School of Medicine at Mount Sinai. Although BPA is present in lots of places including dental sealants, medical equipment, consumer electronics, and cash-register receipts, our main source of exposure are the foods we eat, according to the National Institute of Environmental Health Sciences. - Maida Galvez, MD, MPH, Associate Professor, Preventive Medicine, Pediatrics, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/food/canned-food-safety

Self Magazine – January 7 12 Low Blood Sugar Signs And Symptoms — Korin Miller Low blood sugar, or hypoglycemia, happens when the level of glucose in your blood drops below normal, according to the National Institutes of Health. The people who are most at risk for hypoglycemia are those with diabetes, especially people who are taking medication for diabetes that lowers their blood sugar, including insulin, said Deena Adimoolam, MD, assistant professor of medicine, endocrinology, diabetes, and bone disease at the Icahn School of medicine at Mount Sinai. Other rare conditions, including hormone deficiencies, liver and kidney disorders, and pancreatic tumors, can cause hypoglycemia. And otherwise healthy adults may experience low blood sugar if they’ve been fasting or if they work out after eating for a while, said Dr. Adimoolam. So it’s unlikely you’d have low blood sugar signs without diabetes. She added that the early warning signs tend to be non-specific, meaning that they could indicate someone with high or low blood sugar or could be due to something totally different. - Deena Adimoolam, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/7-signs-you-have-low-blood-sugar

Self Magazine – January 6 11 High Blood Sugar Signs And Symptoms To Watch Out For — Korin Miller Higher blood sugar – hyperglycemia – occurs when the level of glucose in your blood becomes elevated. We get our glucose from food, and most foods we eat impact our blood sugar in one way or another. Luckily, high blood sugar isn’t something most of us have to worry about. “Our body is pretty resilient to controlling blood sugar levels, especially when they’re high,” said Deena Adimoolam, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Normally when you eat something sugary or carb-filled, your pancreas makes insulin, a hormone that your body needs to process glucose. Any glucose that’s leftover is stored in your liver to make sure that it’s not hanging around in your bloods. And, Dr. Adimoolam said, this system works pretty darn well in non-diabetic healthy adults. “A normal person who has no problem with their ability to control glucose should never become significantly hyperglycemic,” she said. If you’ve developed insulin resistance or have diabetes, however, your body isn’t as great at producing the insulin you need to process glucose, which means you’re most at risk for having blood glucose levels that are dangerously high. - Deena Adimoolam, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/signs-of-high-blood-sugar

New York Post – January 9 This Website Can Tell You If You’re An Alcoholic — Lauren Steussy Experts are impressed with the National Institutes of Health’s new Alcohol Treatment Navigator website. First, users take a survey to gauge their level of alcohol-use disorder. The questionnaire lists symptoms of the disorder; the more a user has, the more urgent their need for change. Then, depending on the survey results, the site recommends treatment options, which range from full-blow detox programs to less intensive outpatient therapies. Users are also directed to directories of therapists and clinical facilities, searchable by ZIP code. While this isn’t the first online alcohol-use self-assessment tool, few if any have been as comprehensive as the NIH’s, said Timothy Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the addiction institute at Mount Sinai West. “Not everyone who tests positive will need treatment, but very few with drinking problems will be missed by this test,” added Dr. Brennan. He said that it’s “without a question” one of the best online tools out there for helping people figure out if they need to seek help. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://nypost.com/2018/01/09/this-website-can-tell-you-if-youre-an-alcoholic/

Health24 – January 9 Here’s Why You Should Be Careful When Starting A New Exercise Regimen Getting into shape or losing a few kilograms is a worthy New Year’s resolution, but one that comes with a warning: take it slow. Jumping whole-hog into an exercise regimen is a good way to get yourself hurt if you haven’t worked out in a while, experts say. “People get into trouble when they want to do too much too soon,” said Gerardo Miranda-Comas, MD, assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai. “You need to increase your level of activity gradually, consider it more like a marathon than a sprint,” he said. Keep an eye out for fatigue, chest pain or dizziness as you’re working out – these could be signs that you’re working too hard, Dr. Mirando-Comas added. Trouble sleeping or being in a perpetual bad mood could be signs of overtraining as well. Consider taking a step back or consulting your doctor. - Gerardo E. Miranda-Comas, MD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.health24.com/Lifestyle/Healthy-you/heres-why-you-should-be-careful-when- starting-a-new-exercise-regime-20180109-2

Reader’s Digest – January 9 Six New Rosacea Treatments That Will Help End The Redness — Denise Mann, MS There are many ways to treat pimples and other symptoms of rosacea, but the same couldn’t be said about the redness until now. From laser and lights to new prescription creams and calming over-the- counter skin care products, dermatologists share proven strategies for extinguishing the redness of rosacea for good. Lasers are the gold standard for getting rid of the redness of rosacea, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at the Mount Sinai Hospital. His two go-tos for rosacea treatment are Syneron-Candela’s V-beam and Cutera’s Excel V. Both apply laser energy to get rid of the spider-like vessels that cause redness. “These laser treatments get rid of the blood vessels, but they don’t prevent new ones from forming,” Dr. Goldenberg said. “It’s similar to dyeing your hair in that maintenance treatments will be needed every six to 12 months to keep redness away.” Sun exposure is among the most common rosacea triggers, but the judicious use of sunscreen can help minimize the redness of rosacea, Dr. Goldenberg added. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.rd.com/health/conditions/rosacea-treatment-options/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 10, 2018 Date: Wednesday, January 10, 2018 1:53:13 PM Attachments: ATT00001.txt

In the News January 10, 2018

Politico – January 10 One Smart Upstream Investment Health isn’t just about health. Real improvements in the national health – the kind that increase our average lifespan, boost our prosperity, and maybe even bend the curve of escalating costs – depend on connecting a whole network of services and life influences. Prabhjot Singh, MD, PhD, director of the Arnhold Institute for Global Health and chair in the department of health system design and global health at the Icahn School of Medicine at Mount Sinai, and other experts share ideas to shape the future of national health. “When it comes to solving America’s toughest and most complex health challenges, we cannot only look to our own experience. We need to shift our mind-set and search globally, looking to other countries and societies for locally driven, practical solutions that have endured and spread. Americans are rightly proud of their record of health innovation, but resourceful people in poor, challenging settings have their own remarkable record. For example, we “discovered” community health centers in South Africa, and over the past 40 years, they have spread nationwide in a uniquely American form,” Dr. Singh shared. - Prabhjot Singh, MD, PhD, Director, Arnhold Institute for Global Health, Chair, Department of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai Learn more https://www.politico.com/agenda/story/2018/01/10/reshaping-public-health-roundtable- 000614

Medical Xpress – January 10 Large-Scale Study To Pinpoint Genes Linked To Obesity It's not just diet and physical activity; your genes also determine how easily you lose or gain weight. In a study published in the January issue of Nature Genetics, researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of Anthropometric Traits (GIANT) consortium found 13 genes that carry variations associated with body mass index (BMI). This was the first large-scale study to pinpoint genetic variations that may directly impact the function of the genes. Led by Ruth Loos, PhD, professor at The Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai, and Joel Hirschhorn, MD, PhD, Concordia Professor of Pediatrics and Professor of Genetics at Boston Children's Hospital and Harvard Medical School, and co- director of the Broad Institute Metabolism Program, the study was an international collaboration involving more than 250 research institutions. "Our study has identified genes that play a crucial role in the neuronal control of body weight. They act in the brain in pathways that may affect people's food intake, hunger, satiety, etc. Individuals who inherit these genetic variations may find it harder to eat less or stop eating, as compared to those who did not inherit these variations," said Dr. Loos. "It is also the first time a genetic association study for BMI identifies genes that act in pathways that affect energy expenditure and fat cell biology." - Ruth Loos, PhD, Professor, Environmental Medicine and Public Health, Director, Genetics of Obesity and Related Metabolic Traits Program, Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-01-large-scale-genes-linked-obesity.html Additional coverage: Science Codex http://www.sciencecodex.com/large-scale-study-pinpoint-genes-linked-obesity-618237 Health Medicine Network http://healthmedicinet.com/large-scale-study-to-pinpoint-genes-linked-to- obesity/ MedicalHealthNews.net http://www.medicalhealthnews.net/large-scale-study-to-pinpoint-genes-linked- to-obesity

Science Codex – January 10 Transitional Care Nurses In The Geriatric Emergency Department Reduce Risk Of Inpatient Admissions Geriatric patients seen by transitional care nurses in the emergency department (ED) are less likely to be admitted to the hospital, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the Journal of the American Geriatrics Society. These findings show that interventions initiated during an older patient's arrival through the ED can have a significant impact on care. "These findings will allow hospitals and health care systems to focus on better geriatric emergency care programs for a vulnerable, aging population," says lead investigator Ula Hwang, MD, associate professor of emergency medicine and of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. "At a time when the national average for emergency department admissions with older adults is on the rise, programs that can reduce hospitalization risk are crucial." Hospitalization of older adults carries risks, such as adverse drug effects, falls, cognitive decline, and ulcers. More than 30 percent of older adults develop a hospital-associated disability after an acute admission, and many do not return to their previous functional state. - Ula Hwang, MD, Associate Professor, Emergency Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.sciencecodex.com/transitional-care-nurses-geriatric-emergency-department- reduce-risk-inpatient-admissions-618236 Additional coverage: Health Medicine Network http://healthmedicinet.com/transitional-care-nurses-in-the-geriatric- emergency-department-reduce-risk-of-inpatient-admissions/ Medical Xpress https://medicalxpress.com/news/2018-01-transitional-nurses-geriatric-emergency- department.html

Pain News Network – January 10 Acetaminophen Slows Language Development In Girls — Pat Anson Researchers at the Icahn School of Medicine say toddlers exposed to acetaminophen in the womb had a slower rate of language development at 30 months. The findings are consistent with other studies reporting higher rates of autism, attention deficit disorder (ADHD) and behavioral problems in children born to mothers who used acetaminophen while pregnant. Acetaminophen (paracetamol) is one of the most widely used pain relievers in the world. It is the active ingredient in Tylenol, Excedrin, and hundreds of other pain medications. Researchers say over half the pregnant women in the United States and European Union use the drug. “Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy,” said senior author Shanna Swan, PhD, professor of environmental science and public health, obstetrics, gynecology, and reproductive science at the Icahn School of Medicine at Mount Sinai. “It’s important for us to look at language development because it has shown to be predictive of other neurodevelopmental problems in children.” The study is published online in the journal European Psychiatry. Researchers will follow-up with the children and re-examine their language development at age seven. - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.painnewsnetwork.org/stories/2018/1/10/acetaminophen-slows-language- development-in-girls Additional coverage: TIME Magazine http://time.com/5096715/acetaminophen-pregnancy-language-delays/ Consumer Affairs https://www.consumeraffairs.com/news/study-cautions-against-taking- acetaminophen-while-pregnant-011018.html Economic Times https://economictimes.indiatimes.com/news/science/paracetamol-in-pregnancy-may- delay-daughters-language-skills/articleshow/62445715.cms Medical Xpress https://medicalxpress.com/news/2018-01-acetaminophen-pregnancy-elevated-language- girls.html Science Blog https://scienceblog.com/498837/acetaminophen-use-pregnancy-associated-elevated-rate- language-delay-girls/ Newsweek http://www.newsweek.com/acetaminophen-linked-delayed-language-abilities-girls-776377 Environmental Health News http://www.ehn.org/tylenol-during-pregnancy-baby-health- 2523911049.html The Health Site http://www.thehealthsite.com/news/paracetamol-during-pregnancy-can-delay-speech- development-in-girl-child-ag0118/ The Indian Express http://indianexpress.com/article/lifestyle/health/paracetamol-during-pregnancy-may- delay-daughters-language-skills-5019267/ Business Standard http://www.business-standard.com/article/news-ians/paracetamol-in-pregnancy-may- delay-daughters-language-skills-118011000846_1.html Daily Mail http://www.dailymail.co.uk/health/article-5254069/Go-pregnancy-pain-relieving-drug-delays- babies-speech.html

The Washington Post – January 10 Ibuprofen Appears To Mess With Male Hormones. Should You Be Worried? — Ariana Eunjung Cha In a study published Monday in the Proceedings of the National Academy of Sciences, researchers found that a concentrated dose of the over-the-counter painkiller taken by young, healthy men appears to be linked to a testicular condition that typically only appears at middle age and has been linked to infertility. Studies about environmental factors that may impact male fertility have become more urgent with growing evidence that sperm quality is falling globally. In July 2017, in a large analysis published by the American Society of Andrology, researchers looking at data from 42,000 men between 1973 and 2011 confirmed that there appears to have been a 52.4 percent drop in sperm concentration in those 40 years. The current study focuses on a different measure of the male reproduction system — testosterone production rather than semen analysis. Shanna Swan, PhD, professor of environmental medicine and public health, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and co-author of the 2017 male sperm study, said that the team that worked on the ibuprofen study is known for its pioneering work on the effect of analgesics, until now focused largely on acetaminophen, on reproductive function. Dr. Swan explained that “a large body of evidence points to the role of prenatal exposure to environmental factors that alter the in utero hormonal milieu, causing decreased male reproductive health that persists throughout life.” However, she said, “this would not likely be an issue for ibuprofen” because it’s not typically recommended for use during pregnancy.” - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.washingtonpost.com/news/to-your-health/wp/2018/01/10/ibuprofen-appears- to-mess-with-male-hormones-should-you-be-worried/?utm_term=.b47f7b54123c Additional coverage: The Morning Call http://www.mcall.com/news/breaking/mc-nws-ibuprofen-male-fertility-20180110- story.html The Hamilton Spectator https://www.thespec.com/living-story/8045329-ibuprofen-appears-to-mess-with- male-hormones-should-you-be-worried-/ Gulf News http://gulfnews.com/culture/science/ibuprofen-appears-to-mess-with-male-hormones-should- you-be-worried-1.2154949

ABC News: Good Morning America – January 10 Experts Raise Concerns Flu Could Reach Epidemic Levels – Gio Benitez Emergency rooms across the nation are filling up with the rate of flu hospitalizations doubling in just one week. The CDC said this year’s dominant strain, H3N2, is known to be especially dangerous, making its victims much sicker and at a faster rate than other types of flu. “Historically, the flu has been associated with a high instance of mortality, both in the elderly population and in the very young population,” said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital. Some public health officials fear this is just the beginning. California has already been hit especially hard with 124 deaths across San Diego and Los Angeles counties alone. One of the things the emergency department at the Mount Sinai Hospital is doing for very sick patients admitted to the hospital is a DNA test to see what kind of flu they have. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: https://www.yahoo.com/gma/experts-raise-concerns-flu-could-105036573.html

Medical Laboratory Observer – January 9 Combat Veterans Suffering From Same Brain Disease As Concussion Victims They did not lose limbs, but many veterans exposed to blasts in combat will eventually lose their minds. Just like athletes who endured repeated blows to the head, veterans are suffering from the same degenerative brain disease. A blast wave can damage the brain the same as a physical blow. This blast injury creates a tremendous ricochet or whiplash injury to the brain inside the skull. The effects of the brain are not readily seen on images. Samuel Gandy, MD, PhD, professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai is hoping to change that. He is using new technology to find the markers of CTE in the living in order to inform those who may have the disease and help find a way to stop its deadly progress. These images will be crucial in his work with drug companies to find a treatment. “That’s step one, just to stop it dead in its tracks. And then we can worry about making people feel better,” Dr. Gandy said. - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.mlo-online.com/combat-veterans-suffering-brain-disease-concussion-victims

New York Daily News – January 9 ADHD In Adults And Kids Can Be Managed With ‘Pills And Skills’ — Jeffrey Newcorn, MD Attention deficit hyperactivity disorder (ADHD) affects people at every stage of life, but it can be effectively treated with an approach often summed up this way: pills and skills. Medication can help people manage ADHD, but it doesn't eradicate it. And it is a tool that works best when people are also developing life skills. Doctors estimate that four percent of American adults are living with ADHD, though most of them don't know it. “The underlying causes of ADHD are complex. We know that there is a genetic basis and that ADHD is highly heritable; we think more than one set of genes regulates ADHD, but we don’t know exactly which ones,” said Jeffrey Newcorn, MD, professor of psychiatry and pediatrics, and director of the division of ADHD, learning disabilities, and related disorders at the Icahn School of Medicine at Mount Sinai. “Poor nutrition in utero, prematurity, low birth weight, and perinatal trauma — a trauma just before or after birth — are all associated with ADHD. Lead exposure is another risk factor, though it's not involved in the majority of cases,” Dr. Newcorn added. If you suspect you may be affected, ask your primary care physician for a referral. Receiving treatment and training to manage ADHD could dramatically improve your quality of life. - Jeffrey Newcorn, MD, Professor, Psychiatry, Pediatrics, Director, Division of ADHD, Learning Disabilities and Related Disorders, Icahn School of Medicine at Mount Sinai Learn more: http://www.nydailynews.com/life-style/adhd-adults-kids-managed-pills-skills-article- 1.3747223

Sleep Review Magazine – January 9 As Sleep Surgery Evolves, Sleep Specialists Match Patients Who Fail CPAP To Personalized Treatments — Ofer Jacobowitz, MD, PhD Obstructive sleep apnea is a heterogeneous disease in which patients differ in their severity, physical features, and treatment preferences. “When considering sleep apnea treatment options, whether medical or surgical, all our treatments can benefit certain patients but all are imperfect. So the best treatment modality is the one that is acceptable to the patient and can benefit him or her for the long term,” said Ofer Jacobowitz, MD, PhD, assistant clinical professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. He said he recommends a common-sense approach to the treatment of sleep apnea, in which the goals are quality of life improvement and reduction of medical risk for chronic disease. “I find visual aids and models to be useful when introducing PAP, oral appliances, and surgical option,” added Dr. Jacobowitz. - Ofer Jacobowitz, MD, PhD, Assistant Clinical Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: http://www.sleepreviewmag.com/2018/01/sleep-surgery-personalized-treatments/ Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/as-sleep-surgery-evolves-sleep-specialists- match-patients-who-fail-cpap-to-personalized

Daily Beast – January 10 How America’s Diet Culture Hinders Those With Eating Disorders — Ashley Ross Longstanding research has shown that eating disorders can be hereditary, meaning some people are simple more likely to develop them than others. But new research from the Eating Recovery Center shows there might be a more specific genetic link than previously thought. How do you know if you’re susceptible to eating disorders? As it’s a very complex disease, it’s impossible to pinpoint this, but Tom Hildebrandt, PsyD, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief in the division of eating and weight disorders at the Mount Sinai Health System, said that some things to take note of are whether or not you’re in an environment where restriction and dieting is valued in a critical way, are extremely stressed or are going through a big transition in your life – whether that’s high school to college, college to adulthood, becoming a parent, or even going through menopause. ‘The thing about this time of year is really not to get caught up in the swarm of information that comes from peers, social media and advertisers trying to sell you fixes to it,” Dr. Hildebrandt said. “Try to insulate yourself against that stuff.” - Thomas Hildebrandt, PsyD, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief, Division of Eating and Weight Disorders, Mount Sinai Health System Learn more: https://www.thedailybeast.com/how-americas-diet-culture-hinders-those-with-eating- disorders

Medical Health News – January 8 Preventative Botox: A Smart Choice Or A Waste Of Money? Young people in their twenties are on the rise when it comes to the use of preventative Botox, i.e. getting the procedure done before any real lines or wrinkles appear. The issue has sparked a controversy among doctors who specialize in cosmetic surgery and whether the long-term effects of preventative Botox could be worse than the aging process itself. Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital said that a person should opt for treatment once they notice that lines or wrinkles have begun to stick around. He explained that Botox is not necessary until lines which appear on our face when we smile or frown, become permanent. For some people, this might happen in their mid-twenties, and for others only in their thirties. Dr. Zeichner also added that he would try to avoid doing Botox on a person who was under the age of 25. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: http://www.medicalhealthnews.net/preventative-botox-a-smart-choice-or-a-waste-of-money

Women’s Health – January 8 People Have Been Obsessed With The Zone Diet: But Does It Really Work? — Ashley Mateo The Zone Diet was created to help people lose weight and lower their risk of chronic disease by reducing diet-induced inflammation. The zone is a physiological state in which your body is primed to control inflammation. It’s determined by three clinical markers that measure insulin and other inflammation- promoting hormones. By keeping your body in this zone, the Zone Diet results in losing one to two pounds per week – or that’s at least what its proponents claim. The Zone Diet is a version of a low-carb diet – without making you give up on them completely, said Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes, and bone disease at the Icahn School of Medicine at Mount Sinai. That can make adherence easier. The diet also puts an emphasis on managing insulin, a hormone that regulates the storage of fat, in your system. When your blood sugar spikes – after eating foods like refined carbohydrates, processed foods, and sugary foods – it causes counter-spikes in insulin, which can trigger inflammation. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/weight-loss/zone-diet-results

Men’s Health – January 9 Four Easy Things You Can Do To Prevent Body Odor — Adam Hurly One of the main causes of odor comes from perspiration. That means that one of your best solutions is to wear the right clothing. For workouts, Hooman Khorasani, MD, assistant clinical professor of dermatology and chief in the division of mohs, reconstructive and cosmetic surgery at the Icahn School of Medicine at Mount Sinai, prefers nylon since it wicks away the sweat, dries quickly, breathes easily, and resists mildew. While polyester has many of the same qualities as nylon, be sure to wash it immediately, because polyester more easily accumulates bacteria. For everyday wear, this is when cotton is your best bet. “Lightweight cotton is very breathable and allows some airflow to help dry out dampness,” said Dr. Khorasani. “It is high-quality, ultrasoft, breathable, and absorbent. It also has more resistance to odor, mold, mildew, and bacteria, even after multiple washings.” - Hooman Khorasani, MD, Assistant Clinical Professor, Dermatology, Chief, Division of Mohs, Reconstructive and Cosmetic Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.menshealth.com/guy-wisdom/get-rid-body-odor

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 11, 2018 Date: Thursday, January 11, 2018 3:25:44 PM Attachments: ATT00001.txt

In the News January 11, 2018

HealthDay – January 10 Acetaminophen In Pregnancy Tied To Language Delays In One Sex — Amy Norton Toddlers whose mothers used acetaminophen – best known as Tylenol – early in pregnancy may have a heightened risk of language delays, a new study suggests. Researchers found that when moms-to-be used the painkiller during the first trimester, their daughters were more likely to have language delays at age 2.5 years. The study is the latest to link prenatal acetaminophen to developmental issues. Doctors consider acetaminophen the pain and fever reliever of choice during pregnancy. According to senior author Shanna Swan, PhD, professor of environmental science and public health, obstetrics, gynecology, and reproductive science at the Icahn School of Medicine at Mount Sinai, “There really is no good alternative to acetaminophen.” Yet evidence is growing that there can be risks from taking the drug during pregnancy, especially more than occasionally, added Dr. Swan. “I think the message is, consult your doctor before taking this drug during pregnancy, and only take it for a medically indicated use,” she said. - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/kids-health-information-23/child-development-news-124/acetaminophen-in-pregnancy-tied-to-language-delays-in-one-sex-730059.html Additional coverage: International Business Times http://www.ibtimes.com/acetaminophen-use-among-pregnant-women-could-cause-speech-delay-girls-2639724 Romper https://www.romper.com/p/taking-acetaminophen-during-pregnancy-could-have-negative-effects-study-finds-7844775 Pain News Network https://www.painnewsnetwork.org/stories/2018/1/10/acetaminophen-slows-language-development-in-girls Medical News Today https://www.medicalnewstoday.com/articles/320584.php

News Medical & Life Sciences – January 10 Study Finds Genetic Variations Linked To BMI And Obesity Risk It's not just diet and physical activity; your genes also determine how easily you lose or gain weight. In a study published in the January issue of Nature Genetics, researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of Anthropometric Traits (GIANT) consortium found 13 genes that carry variations associated with body mass index (BMI). This was the first large-scale study to pinpoint genetic variations that may directly impact the function of the genes. Led by Ruth Loos, PhD, professor at The Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai, and Joel Hirschhorn, MD, PhD, Concordia Professor of Pediatrics and Professor of Genetics at Boston Children's Hospital and Harvard Medical School, and co-director of the Broad Institute Metabolism Program, the study was an international collaboration involving more than 250 research institutions. "Our study has identified genes that play a crucial role in the neuronal control of body weight. They act in the brain in pathways that may affect people's food intake, hunger, satiety, etc. Individuals who inherit these genetic variations may find it harder to eat less or stop eating, as compared to those who did not inherit these variations," said Dr. Loos. "It is also the first time a genetic association study for BMI identifies genes that act in pathways that affect energy expenditure and fat cell biology." - Ruth Loos, PhD, Professor, Environmental Medicine and Public Health, Director, Genetics of Obesity and Related Metabolic Traits Program, Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180110/Study-finds-genetic-variations-linked-to-BMI-and-obesity-risk.aspx

CBS New York – January 10 Hair-Sized Stent Offers Hope For Patients Suffering From Glaucoma — Dr. Max Gomez A tiny new device could help prevent a leading cause of blindness. The glaucoma implant is the size of a human hair, and was just approved by the Food and Drug Administration. Glaucoma is dangerous because it doesn’t cause symptoms until you’ve permanently lost vision; the device provides new hope for patients who aren’t helped by eye drops or surgery. “It’s also made of a very nice material that’s well tolerated by the human body whereby you plant it, the body doesn’t form a lot of scar tissue around it,” said Joseph Panarelli, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, associate residency director and the glaucoma fellowship director at the New York Eye and Ear Infirmary of Mount Sinai. “Because it’s minimally traumatic to the tissue, patients will often come back on day one or week one and say, ‘I see pretty well already’,” said Dr. Panarelli. “Versus a lot of our traditional glaucoma procedures, patients will take months to recover.” - Joseph Panarelli, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Associate Residency Program Director, Glaucoma Fellowship Director, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://newyork.cbslocal.com/2018/01/10/tiny-device-prevents-glaucoma/

Genome Web – January 10 A Single Gene Can Either Raise Or Lower Crohn’s Disease Risk — Andy Coghlan A gene behind Parkinson's disease can also influence an individual's chances of developing Crohn's disease, according to research by an international team led by investigators at Yale University and the Icahn School of Medicine at Mount Sinai. The researchers began by using exome sequencing and genotyping to search for Crohn's disease-associated genetic variants in nearly 5,700 individuals of Ashkenazi Jewish ancestry — a population at enhanced risk of developing the inflammatory bowel disease. We identified independent coding [Crohn's disease] risk and protective alleles in LRRK2, a large multifunctional gene that confers the greatest genetic effects reported thus far in Parkinson's disease," Mount Sinai genetics and genomic researchers Igna Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai and Judy Cho, MD, director for the institute for personalized medicine and professor of genetics, genomic sciences, medicine, and gastroenterology at the Icahn School of Medicine at Mount Sinai. The team went on to explore this overlap in a series of cell line and patient-derived cell culture experiments, characterizing the consequences of the protective and risky LRRK2 variants on the kinase enzyme activity and other functional features of the resulting protein. - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai - Judy H. Cho, MD, Director, Institute for Personalized Medicine, Professor, Genetics and Genomic Sciences, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://www.genomeweb.com/sequencing/crohns-parkinsons-diseases-share-risk-gene Additional coverage: New Scientist https://www.newscientist.com/article/single-gene-can-either-raise-lower-crohns-disease-risk/

The New York Times – January 11 For Serena Williams, Childbirth Was A Harrowing Ordeal. She’s Not Alone. — Maya Salam Not even the tennis dynamo Serena Williams is immune from the complications and challenges new mothers face during and after childbirth. The day after giving birth to her daughter via cesarean section, Ms. Williams was having trouble breathing and immediately assumed she was having another pulmonary embolism. She alerted a nurse to what she felt was happening in her body and asked for a CT scan and a blood thinner, but the nurse suggested that pain medication had perhaps left Ms. Williams confused. When the ultrasound revealed nothing, she underwent a CT scan, which showed several small blood clots in her lungs. She was immediately put on the heparin drip. About 700 women die each year in the United States as a result of pregnancy or delivery complications, according to the Centers for Disease Control and Prevention. Poverty, access to care, culture, communication and decision-making all contribute to disparities, said Elizabeth Howell, professor of obstetrics, gynecology and reproductive science and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai. Still, the problem is often attributed incorrectly solely to poverty, she said. “Everyone always wants to say that it’s just about access to care and it’s just about insurance, but that alone doesn’t explain it,” said Dr. Howell, whose research focuses on quality of care and racial and ethnic disparities in maternal and child health. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/01/11/sports/tennis/serena-williams-baby-vogue.html?rref=collection%2Fbyline%2Fmaya- salam&action=click&contentCollection=undefined®ion=stream&module=stream_unit&version=latest&contentPlacement=1&pgtype=collection&referer=https://www.nytimes.com/by/maya- salam

ABC News: World News Tonight – January 10 Experts Raise Concerns Flu Could Reach Epidemic Levels Emergency rooms across the nation are filling up with the rate of flu hospitalizations doubling in just one week. The CDC said this year’s dominant strain, H3N2, is known to be especially dangerous, making its victims much sicker and at a faster rate than other types of flu. “Historically, the flu has been associated with a high instance of mortality, both in the elderly population and in the very young population,” said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital. Some public health officials fear this is just the beginning. California has already been hit especially hard with 124 deaths across San Diego and Los Angeles counties alone. One of the things the emergency department at the Mount Sinai Hospital is doing for very sick patients admitted to the hospital is a DNA test to see what kind of flu they have. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://abc.go.com/shows/world-news-tonight/episode-guide/2018-01/10-011018-more-than-a-dozen-still-missing-in-california-mudslides

Health News Digest – January 9 January Is Thyroid Awareness Month January is Thyroid Awareness Month, and physicians from the Department of Otolaryngology-Head and Neck Surgery at the Mount Sinai Health System are emphasizing the importance of being aware of symptoms that may be related to thyroid disease. “Because the thyroid gland growth and function are under hormonal control, women are at a great risk of developing thyroid dysfunction and thyroid cancer. Thyroid cancer often affects younger patients, and it is important to be aware of the early signs and symptoms,” said Ilya Likhterov, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “Lumps or swelling in the neck may be thyroid nodules that, while not always cancerous, should be brought to the attention of your doctor. Pain in the center of the neck, new voice changes, or trouble swallowing or breathing can be symptoms of thyroid cancer and should be evaluated, especially if they persist.” - Ilya Likhterov, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Learn more: http://www.healthnewsdigest.com/news/Disease_420/January-Is-Thyroid-Awareness-Month.shtml

Refinery 29 – January 10 Why Serena Williams Was Bedridden After Giving Birth — Kimberly Truong Serena Williams, who has previously suffered from blood clots, realized something was wrong when she suddenly felt short of breath while recovering from her C-section in the hospital the day after she gave birth. Given her health history, she had a gut instinct that she was suffering a pulmonary embolism, a condition that develops when a blood clot in another part of your body breaks off and travels along the blood stream and into your lungs, blocking the pumping of your heart, and preventing your heart from taking in oxygen. Louis DePalo, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai, said that pregnant women are particularly at risk for blood clots. In addition to hormonal changes that make blood clots more likely, “As the baby grows in the uterus, it can compress the veins in the pelvis, and cause slower blood flow,” he said, which in turn can contribute to blood clots. - Louis DePalo, MD, Professor, Medicine, Pulmonary, Critical Care, Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.refinery29.com/2018/01/187517/pulmonary-embolism-pregnancy-serena-williams

This Week In Microbiology – January 4 I Have One Word For You: Flink — Michele Swanson, Vincent Racaniello, and Michael Schmidt Vincent Rancaniello, Michele Swanson, and Michael Schmidt speak with Stuart C. Sealfon, MD, professor of neurology, neuroscience, and pharmacological sciences at the Icahn School of Medicine at Mount Sinai about how the pandemic influenza viruses suppress immunogenic cell death. - Stuart C. Sealfon, MD, Professor, Neurology, Neuroscience, Pharmacological Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.microbe.tv/twim/

The Huffington Post – January 11 Six Winter Skin Care Tips From Dermatologists — Julia Brucculieri If you live in a part of the world that experiences cold weather, you’ll know that frigid temperatures can wreak havoc on your skin, both on the face and body. It gets dry, flaky and can sometimes even crack, which can be painful or itchy. Angela Lamb, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of the west side Mount Sinai dermatology faculty practice said, our skin “is the barrier that keeps water inside of your body, so when it is dry and cold, water evaporates off of the surface faster and easier.” To prevent dryness, Dr. Lamb recommended using a humidifier and suggested “drinking an extra glass or two of water.” - Angela Lamb, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Westside Mount Sinai Dermatology Faculty Practice - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.huffingtonpost.com/entry/winter-skin-tips_us_5a53e784e4b003133ecb658c Additional coverage: Self Magazine https://www.self.com/story/dry-cracked-winter-skin

Well + Good – January 10 These Are The Six Products To Use Before bed, According To Dermatologists — Meg Storm Regardless of skin type or concern, night creams are meant to work with the body’s natural circadian rhythm to treat damage and replenish skin, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. “We know that the skin has its lowest levels of hydration at the end of the day,” he explained. “We also know that the skin undergoes cell division overnight, making it an optimal time to apply products that help strengthen the skin.” So while your day cream should undoubtedly be protecting skin from environmental aggressors, your night cream needs to be packed with reparative ingredients. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.wellandgood.com/good-looks/dermatologist-picks-night-creams-and-serums/

Stylecaster – January 10 Here’s Why More Adults Have More Acne Than Teens — Nykia Spradley Even if you didn’t suffer from acne as a teen, the cold hard truth is you can still experience it as an adult. Melissa K. Levin, MD, clinical instructor of dermatology at the Icahn School of Medicine at Mount Sinai breaks down the science behind this shift and how to treat it post-adolescence. Certain hormones, particularly testosterone, trigger increased oil production promoting acne. The surge in those hormones could be from your period, pre-menopause, menopause, starting or stopping birth control, a hormonal IUD (intrauterine devices), or eating hormone-enhanced foods. “Women are more likely to deal with adult acne than men due to hormonal changes,” Dr. Levin says. Some of Dr. Levin’s in-office treatment options are blue and red LED light therapy, which uses anti-bacterial and anti-inflammatory lights. There’s also radiofrequency microneedling to deliver heat energy down to the pores in order to essentially heat and ablate the oil glands to destroy oil production. - Melissa K. Levin, MD, Clinical Instructor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: http://stylecaster.com/beauty/adults-suffer-acne-more-than-teens/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 12, 2018 Date: Friday, January 12, 2018 12:19:37 PM Attachments: ATT00001.txt

In the News January 12, 2018

CNBC News – January 11 The Real Reason Health Care Is Bankrupting America — Kenneth L. Davis, MD The United States spends far more on health care than any other nation on the globe: $10, 348 per person, which amounts to nearly 18 percent of gross domestic product. That is eight percentage points above the average of the industrialized member nations of the Organization for Economic Co-Operation and Development. Medicare has been growing at more than twice the rate of inflation and is forecast to accelerate as baby boomers age, while the cost of Medicaid has grown as the Affordable Care Act has brought Medicaid coverage to more people. Kenneth Davis, MD, president and CEO of the Mount Sinai Health System says it is “little wonder that congressional leaders are looking to chop Medicare and Medicaid spending, which have long been favorite targets of budget-cutters. As part of its effort to replace the ACA, Congress last year tried to eliminate full dollar-for-dollar sharing of Medicaid costs between the federal and state governments and replace it with finite block grants to the states.” He said instead of volume, “we need to incentivize value by rewarding better health outcomes resulting from efficiently delivered, proactive care that keeps patients healthy.” The Hospital at Home concept, which Mount Sinai Health System began in 2014, allows patients to be monitored closely from their own bedrooms and receive daily visits from a doctor or nurse practitioner, as well as home nursing care, lab services and medical equipment in their home, which is far less costly than remaining in the hospital. We need a payment system that stops rewarding health-care providers as if they are factories and, instead, one that will be beneficial for providers, payers and patients. Rather than indiscriminate cost cutting, value-based care is the smart way to bend the health-care cost curve. It will improve patient health, as well as the nation's fiscal and economic health, Dr. Davis added. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System Learn more: https://www.cnbc.com/2018/01/11/the-real-reason-health-care-is-bankrupting-america.html Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/ceo-of-bmount-sinaib-health-system

Crain’s Health Pulse – January 12 Mount Sinai Opens StuyTown Practice — Jonathan LaMantia Mount Sinai Health System opened a 5,000-square-foot multispecialty practice in Stuyvesant Town-Peter Cooper Village Thursday. The facility is part of its strategy to expand ambulatory care downtown while it reduces the size of Mount Sinai Beth Israel. The new location, at 518 E. 20th St., offers primary care and pediatrics as well as orthopedics, OB/GYN, podiatry and dermatology services. It has an X-ray machine and can treat a higher-acuity patient than a typical primary care office, but it isn't quite as sophisticated as major multispecialty practices, such as Mount Sinai Union Square, said Jeremy Boal, MD president of the Mount Sinai Downtown Network and chief medical officer of the Mount Sinai Health System. Dr. Boal, who lives in Stuyvesant Town, has noticed an unmet need for primary care for the area's 30,000 residents. "We've seen a lot of physicians who traditionally served the StuyTown community age out without a lot of replacements," he said. Mount Sinai Downtown has 600 doctors and 18 ambulatory-care sites south of 34th Street. "The bulk of care people need can and should be delivered in the community," Dr. Boal said. - Jeremy Boal, MD, President, Mount Sinai Downtown, Chief Medical Officer, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180112/PULSE/180119965/full-legalization-of- cannabis-weighed-by-assembly (Subscription required) Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/12/h-h-finances-improve-023925 MedicalHealthNews.net http://www.medicalhealthnews.net/bmount-sinaib-health-system-opens-new- specialty-practice-at-stuyvesant-town-peter-cooper-village

Medical Xpress – January 11 Research Discovers Possible Link Between Crohn’s And Parkinson’s In Jewish Population Mount Sinai Researchers have just discovered that patients in the Ashkenazi Jewish population with Crohn's disease are more likely to carry the LRRK2 gene mutation. This gene is the major genetic cause of Parkinson's disease, which is a movement disorder. The study's findings, published in Science Translational Medicine, could help doctors better understand Crohn’s disease, determine specifically who’s at risk, and develop new drugs for treatment and/or prevention by targeting this specific gene. "Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry," explained lead researcher Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. "The presence of shared LRRK2 mutations in patients with Crohn's disease and Parkinson's disease provides refined insight into disease mechanisms and may have major implications for the treatment of these two seemingly unrelated diseases." The study’s co-author, Judy H. Cho, MD, director of the institute for personalized medicine at the Icahn School of Medicine at Mount Sinai said, "Defining the biology of naturally occurring protective mutations is quite important, because they define desired outcomes for potentially new therapies.” - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai - Judy H. Cho, MD, Director, Institute for Personalized Medicine, Professor, Genetics and Genomic Sciences, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-01-link-crohn-parkinson-jewish-population.html Additional coverage: Nature https://www.nature.com/articles/d41586-018-00591-8 The Jewish Chronicle https://www.thejc.com/news/world/jews-with-crohn-s-disease-more-likely-to- develop-parkinson-s-study-shows-1.451959 Fast Forward https://forward.com/fast-forward/391975/ashkenazi-jews-with-crohns-disease-more-likely- to-have-parkinsons-gene-stud/ News Medical & Life Sciences https://www.news-medical.net/news/20180111/Mount-Sinai-study- uncovers-potential-link-between-Crohns-and-Parkinsons-in-Jewish-population.aspx

Nursing Times – January 11 Transitional Care Nurses In A&E ‘Reduce Older Inpatient Admissions’— Steve Ford Basing specialist nurses trained in transitional care within the accident and emergency department can significantly reduce the number of admissions among older patients, according to a U.S. study. Researchers looked at the impact of an initiative called the Geriatric Emergency Department Innovations in Care through Workforce, Informatics, and Structural Enhancement (GEDI WISE). The model is being tried out at Mount Sinai Health System. GEDI WISE involves a transitional care nurse based in A&E to identify patients with geriatric-specific health needs and to co-ordinate their transition from the emergency department to home. Lead study author, Ula Hwang, MD, associate professor of emergency medicine, geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai, said, “These findings will allow hospitals and healthcare systems to focus on better geriatric emergency care programs for vulnerable, aging population. At a time when the U.S. national average for emergency department admissions with older adults is on the rise, programs that can reduce hospitalization risk are crucial,” she added. - Ula Hwang, MD, Associate Professor, Emergency Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.nursingtimes.net/news/hospital/transitional-care-nurses-in-ae-reduce-older- inpatient-admissions/7022755.article

Science Daily – January 10 Common Pain Reliever Use During Pregnancy Linked To Language Delay In Girls In the first study of its kind, researchers from the Icahn School of Medicine at Mount Sinai found an elevated rate of language delay in girls at 30 months old born to mothers who used acetaminophen during pregnancy, but not in boys. Acetaminophen was used by 59 percent of the women in early pregnancy. Acetaminophen use was quantified in two ways: High use vs. no use analysis used women who did not report any use as the comparison group. For the urine analysis, the top quartile of exposure was compared to the lowest quartile. "Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy," said the study's senior author, Shanna Swan, PhD, professor of environmental and public health at the Icahn School of Medicine at Mount Sinai. "It's important for us to look at language development because it has shown to be predictive of other neurodevelopmental problems in children." - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: Additional coverage: https://www.sciencedaily.com/releases/2018/01/180110080556.htm MedPage Today https://www.medpagetoday.com/obgyn/pregnancy/70452 Medicine Net https://www.medicinenet.com/script/main/art.asp?articlekey=209421

Time Magazine – January 11 The Flu Killed A Healthy 21-Year-Old Man. Here’s How That Can Happen — Jaime Ducharme Most people view influenza as a routine, if unpleasant, possibly each winter. But the case of a 21 year old man in Pennsylvania is a poignant reminder that sometimes, the worst-case scenario is more serious than sick days and bed rest. Kyle Baughman, an aspiring personal trainer, came home for Christmas not feeling well. His symptoms persisted after returning to work after the holiday. Just a few days later, however, Kyle Baughman died at University of Pittsburg Medical Center Presbyterian hospital from flu- related organ failure, according to his family. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at the Mount Sinai Hospital said that influenza can be a very serious illness, even though the vast majority of the public that comes down with actual influenza will get through it with Tylenol, fluids, Motrin, whatever, there are people who do get very sick.” Deadly cases are mostly limited to the very young, the elderly and those with pre-existing conditions, such as respiratory illnesses, but Dr. Shearer said a very small percentage of otherwise healthy people do develop serious complications. If you’re seeking treatment, the emergency room shouldn’t necessarily be your first choice, said Dr. Shearer, as you’ll run the risk of infecting others and exposing yourself to sickness potentially more severe than yours. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://time.com/5099042/influenza-deaths-flu/ Additional coverage: Yahoo News https://sg.news.yahoo.com/flu-killed-healthy-21-old-185404372.html Daily Magazine http://www.dailymagazine.news/the-flu-killed-a-healthy-21-year-old-man-here-apos-s- how-that-can-happen-nid-537008.html

Gluten-Free Living Magazine – January 12 Steps Toward Health In The New Year — Susan Cohen Even though any day is a great day to start taking proactive health measures, the start of a new year is seen as the chance to really start focusing on health. In many respects, individuals with diagnosed celiac do not need January 1st as a reminder because every day is about making choices to stay healthy by living a completely gluten-free life. In the long term, diet plays a huge role on health. “If someone does not eat a balanced diet, over time your body will pay the price,” said Laura Manning, MPH, RD, CDN, clinical nutrition coordinator at the Susan and Leonard Feinstein IBD clinical center at the Mount Sinai Health System. “It is OK to have processed food here and there, but to have it on a regular basis will potentially add a lot more calories, salt, fat, and sugar that you don’t need.” The benefits of exercise are body wide. Manning notes, “It is an integral part of wellness that needs equal attention to diet.” She points out that “getting daily exercise can help keep you mobile, build lean muscle mass, increase bone density, increase your cardiovascular level and lower your risk for chronic disease.” In addition to physical benefits, “Exercise is also a great way to relieve stress,” she said. - Laura Manning, MPH, RD, CDN, Clinical Nutrition Coordinator, Susan and Leonard Feinstein IBD Clinical Center, Mount Sinai Health System Learn more: No link available

AccuWeather – January 11 Five Hacks To Rescue Dry Skin From Winter’s Harsh Effects — Ashley Williams Harsh wintry conditions can wreak havoc on the skin, stripping it of its natural moisture and leaving it feeling parched, tight and sometime itchy. Signs of winter skin include rash, redness, chapped lips, flakiness and tiny, itchy bumps. Cold weather can be very damaging to the skin, and during winter, the skin requires various types of moisturizers. Ingredients in moisturizers are usually divided into categories that include occlusive agents and humectants. “Occlusive agents are ingredients that coat the skin’s surface to prevent water from evaporating, similar to plastic wrap,” said Melissa K. Levin, MD, clinical instructor in dermatology at the Icahn School of Medicine at Mount Sinai. Examples of occlusive agents include petrolatum, oils, lanolin, and silicone. “Humectants are ingredients that bind water and draw water into themselves and onto the skin’s surface, pumping the skin,” she added. Experts suggested moisturizing your skin at least twice daily to prevent dryness and cracking. - Melissa K. Levin, MD, Clinical Instructor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.accuweather.com/en/weather-news/5-hacks-to-rescue-dry-skin-from-winters- harsh-effects/70003814

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 16, 2018 Date: Tuesday, January 16, 2018 2:28:09 PM Attachments: ATT00001.txt

In the News January 16, 2018

Medical Xpress – January 16 Researchers Identify Protein Involved In Cocaine Addiction Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction. A study showed that G-CSF can alter a mouse's desire for cocaine, but not for other rewards. This effect is modulated by a brain region that plays a central role in reward processing and addiction. If applicable to humans, these findings represent a potential therapeutic approach to decrease a cocaine addict's motivation to seek the drug without introducing a potential new substance for abuse. The results of the study will be published online in Nature Communications. "The results of this study are exciting because outside of 12-step programs and psychotherapy, no medication-assisted therapy exists to treat cocaine addiction," said the study's senior author, Drew Kiraly, MD, PhD, assistant professor of psychiatry at Icahn School of Medicine at Mount Sinai. "Drugs that manipulate G-CSF already exist as FDA-approved medications. Once we clarify how G-CSF signaling can best be targeted to reduce addiction-like behaviors, there is a high possibility that treatments targeting G-CSF could be translated into clinical trials and treatments for patients." - Drew Kiraly, MD, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-01-protein-involved-cocaine-addiction.html Additional coverage: Dotemirates https://www.dotemirates.com/en/details/4421634?from=dot

The Jerusalem Post – January 15 Researchers Discover Possible Link Between Crohn’s And Parkinson’s Among Ashkenazim — Judy Siegel A possible link between Crohn’s and Parkinson’s diseases has been identified in Ashkenazi Jews. Researchers at the Icahn School of Medicine at Mount Sinai have found that Jews of European origin who suffer from Crohn’s, a chronic gastroenterological disease, are more likely to carry the LRRK2 gene mutation, which is a leading genetic cause of Parkinson’s, an incurable neurological movement disorder. The findings of the team, headed by Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, were just published in the journal Science Translational Medicine. The discovery could help doctors better understand Crohn’s disease, determine specifically who’s at risk, and develop new drugs for treatment and/or prevention by targeting this specific gene. “Crohn’s is a complex disorder with multiple genes and environmental factors involved, which disproportionately affects individuals of Ashkenazi Jewish ancestry,” Dr. Peter explained. The study’s co-author, Judy H. Cho, MD, director of the Institute for Personalized Medicine and professor of genetics and genomic sciences, medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai said, “Defining the biology of naturally occurring protective mutations is quite important, because they define the desired outcomes for potentially new therapies.” - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai - Judy H. Cho, MD, Director, Institute for Personalized Medicine, Professor, Genetics and Genomic Sciences, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: No link available. Additional coverage: Parkinson’s News Today https://parkinsonsnewstoday.com/2018/01/16/parkinsons-disease-may-share- genetic-link-with-crohns-disease/ IBD News Today https://ibdnewstoday.com/2018/01/16/study-identifies-lrrk2-gene-as-potential-link- between-crohns-parkinsons/ MedicalHealthNews.net http://www.medicalhealthnews.net/lrrk2-gene-may-link-crohn39s-and- parkinson39s-among-ashkenazi-jews-study-finds Drug Discovery & Development https://www.dddmag.com/news/2018/01/researchers-discover-possible- link-between-crohns-parkinsons-disease-jewish-population

What To Expect – January 12 Can I Take Tylenol During Pregnancy? New Study Says Yes, But With Caution — Colleen De Bellefonds Studies have found that about half of pregnant women in the U.S. took acetaminophen during their first trimester. However, a new study suggests you should still pop acetaminophen – with caution. Frequent use during early pregnancy has been linked to language delays in girls at 30 months old. Some research has shown that language development is sensitive to change in the balance of the sex hormones androgen and estrogen. Researchers in this study set out to answer if there really does appear to be a link between mom’s acetaminophen use during pregnancy, baby’s sex and baby’s language skills later in life. While there is a link between acetaminophen use and a change in sex hormone levels, it’s not yet clear why that’s linked to language, said the study's senior author, Shanna Swan, PhD, professor of environmental and public health at the Icahn School of Medicine at Mount Sinai. As a general rule, girls tend to be better at language than boys, Dr. Swan explained. But “the advantage girls have in language seems to be decreased when mom takes Tylenol,” she said. All of this said, Dr. Swan said you shouldn’t avoid taking acetaminophen if you really need it and your doctor recommends it. In fact a high fever, for example, can result in serious consequences for your baby; taking acetaminophen as recommended by your doctor is absolutely necessary. - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.whattoexpect.com/news/pregnancy/study-acetaminophen-pregnancy- language-delays-babies/

ABC News – January 15 Seven-Year-Old Hears Out Of Both Ears For The First Time After Life-Changing Surgery — Diana Williams Seven year old Teesa has been mostly deaf for her entire life; a life changing surgery at the New York Eye and Ear Infirmary at Mount Sinai allows Teesa to hear clearly for the first time. Kathleen Arden adopted Teesa, after she spent the first year of her life at an orphanage in India. Teesa was never taught sign language, so she had little to no communication skills. She would only make small gestures to indicate she was hungry. “She has been through quite a lot in her seven years and has not been able to tell anyone about it because she doesn’t have, right now, a very reliable mode of communication,” said Maura Cosetti, MD, director of the cochlear implant center at the New York Eye and Ear Infirmary of Mount Sinai. That began to change back in August when Tessa had cochlear implant surgery in one ear at the New York Eye and Ear Infirmary of Mount Sinai. Four months later, Tessa had the implant surgery on the other ear. Mount Sinai doctors used a new type of implant that was just approved by the FDA. It is thinner and softer, and could help a person hear even better. - Maura K. Cosetti, MD, Assistant Professor, Otolaryngology, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, Cochlear Implant Center, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://abc7news.com/society/7-year-old-hears-out-of-both-ears-for-first-time/2949622/

NBC News – January 15 Serena Williams Shares Her Harrowing Childbirth Story — Rehema Ellis The tennis legend, Serena Williams, shares her harrowing childbirth story. Serena had trouble breathing, she knew it was a sign of blood clots she had suffered before, and so she guided her doctors on how to save her life. She tells her story in hopes of raising awareness that black women are three to four times more likely to die in childbirth than white women. Elizabeth Howell, MD, MPP, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean for academic development and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai said, “Just this idea that somebody like her could experience such a severe complication is really upsetting to many people and will bring more attention to this issue.” Every year, 50,000 women suffer complications during pregnancy, 700 die. “We should all play a role in advocating for ourselves within the healthcare system,” added Dr. Howell. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnews.com/nightly-news/video/serena-williams-shares-her-harrowing- childbirth-story-1137563203562

Before It’s News – January 16 Medical Experts: Worst Flu Season In History — Hal Turner Medical experts in the United States are worried that this year’s flu season could be the worst in U.S. History as 46 states already report Flu outbreaks. This year’s main flu strain, the influenza A virus, known as H3N2, is worse than the swine flu in 2009. A string of bad flu seasons has had medical experts calling for the development of a universal influenza vaccine that would save lives. The definition of a universal flu vaccine is somewhat flexible. Ideally, a single injection would protect against all known and emerging influenza A strains and last a lifetime, said Peter Palese, PhD, professor and chair of microbiology and professor of infectious diseases at the Icahn School of Medicine at Mount Sinai. More modest proposals envision a one-shot vaccine that would protect against getting the flu for anywhere from three to 20 years. Dr. Palese’s laboratory is one of three different research groups at Mount Sinai exploring a universal flu vaccine and one of numerous efforts underway mostly in academia, biotech firms and NIH. Dr. Palese’s team has developed a universal flu vaccine that is now in the first phase of testing in humans. “What changes in the influenza virus from year to year is the hemagglutinin,” Dr. Palese explained, “which is a major protein against which we make an immune response.” - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://beforeitsnews.com/health/2018/01/medical-experts-worst-flu-season-in-history- 2808120.html

Medscape – January 15 Obesity Paradox Prevails For PCI In Women— Patrice Wendling Adjusted analyses from the largest study so far examining the effects of body mass index (BMI) in women undergoing PCI with a drug-eluting stent (DES) show that BMI had no effect on adverse cardiac events, that being overweight or mildly obese conferred a survival benefit, and being underweight increased the risk for all-cause and cardiac death more than twofold. The findings are consistent with those observed in men undergoing PCI but also call attention to the higher risks known to exist for underweight women, said senior author, Roxana Mehran, MD, professor of medicine, cardiology, population health science and policy and director of interventional cardiovascular research and clinical trials and the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. "The fact that we didn't show more MIs, more recurrent revascularizations, and other end points is not as significantly important as us understanding that the all-cause mortality, when you correct for everything after PCI in these small, frail ladies, is much higher,” Dr. Mehran said. “We need to pay special attention to these patients, understand what their follow-up is, and how to care for them.” - Roxana Mehran, MD, Professor, Medicine, Cardiology, Population Health Science and Policy, Director, Interventional Cardiovascular Research and Clinical Trials, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/891308

The Ophthalmologist – January 2018 ‘Un-Eclipsing’ Solar Harm August 21, 2017, marked the first total solar eclipse since February 26, 1979, to be visible anywhere in the United States. But despite a comprehensive campaign advising people to take precautions to protect their eyes when viewing the eclipse, inevitable, some didn’t. One such casualty presented at the New York Eye and Ear Infirmary of Mount Sinai three days after directly viewing the eclipse. The patient had viewed the solar rim for around six seconds on several occasions without using eclipse glasses. Realizing that the patient was exhibiting classic signs of solar retinopathy, the team involved in her care decided to find out more about the pathology of this rare condition, publishing what they found in JAMA Ophthalmology. - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: https://theophthalmologist.com/issues/0118/un-eclipsing-solar-harm/

OZY – January 16 What We Get Wrong About The Future Of Medicine— Jennifer Mattson Medical breakthroughs have always served as beacons of hope. We pin our optimism to findings that might eradicate – or even reverse – the disease we fear most. Over the past couple years, looking to genes to determine predisposition to illness and disease has been lauded as the big answer in a new era of health care. The real key is to identify the earliest disease transition and learn how to reverse it at that earliest stage. Doctors are able to both prevent and reverse diabetes and Alzheimer’s if diagnosed at that earliest stage. In the coming years, that will apply to many more diseases, including cancer. So, does this mean our genes are our destiny? According to a number of experts in the field of genomics – it’s not. “A lot of people think about the genome as something passed down from our parents as DNA, but it’s just sheet music,” said Joel Dudley, PhD, director of the Next Generation Healthcare Institute, and associate professor of genetics and genomic sciences, population health science and policy at the Icahn School of Medicine at Mount Sinai. “One thing is to identify a gene,” said Dr. Dudley. “It’s changing minute by minute. Genes can be activated or deactivated in seconds. The function is very dynamic. That’s where the big data comes in; you have to measure it.” Dr. Dudley and his team are taking that idea one step further, launching the doctor’s office of the future. Using artificial intelligence and millions of measurements, they are building a new type of clinic. - Joel Dudley, PhD, Director, Next Generation Healthcare Institute, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: http://www.ozy.com/fast-forward/what-we-get-wrong-about-the-future-of-medicine/83150

Metro NY – January 15 How To Learn Mindfulness In 2018 — Sheila Dougherty In recent years, “mindfulness” has become a buzzword well beyond the confines of yoga retreats. Schools, corporation and even prisons have embraced the concept in an effort to promote peace and community-building. Elizabeth Ochoa, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief psychologist at Mount Sinai Beth Israel said, “Mindfulness is a mental activity that promotes self-awareness and the ability to focus on mind and body experiences in the moment. It has a soothing, calming effect for many people.” She said that mindfulness is often included by mental health clinicians as a treatment technique in psychotherapy to help people manage stress and other types of emotional distress. She added that it “teaches us discipline, consistency, and self- awareness, which can lead to effective problem solving. Mindfulness encourages forgiving.” She said that there are a variety of great online apps that can help you get started with a practice of your own at your own pace. - Elizabeth Ochoa, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief Psychologist, Mount Sinai Beth Israel Learn more: https://www.metro.us/body-and-mind/health/how-to-practice-mindfulness

Medscape – January 16 Vitamins For Age-Related Macular Degeneration — Ronald C. Gentile, MD and John M. Aljian, MD Ronald C. Gentile, MD, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and director of the ocular trauma service at the New York Eye and Ear Infirmary of Mount Sinai, and John M. Aljian, MD, associate clinical professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, discuss vitamin therapy for the most common cause of vision loss in U.S. adults: macular degeneration. “There seems to be confusion and uncertainty among our patients about whether or not they should be taking vitamins and supplements, how much they should be taking, and why they should be taking them, along with compliance issues,” said Dr. Aljian. He said that when it comes to vitamin therapy and vision, there seems to be some reluctance. Dr. Gentile said, “Vitamin supplements are very common, and the vitamin and supplement industry is huge. There are very few things out in the literature that are as strong as vitamins for age-related macular degeneration (AMD).” He added that the AREDS and AREDS2 formulas are helpful in preventing AMD to as many patients as possible who are candidates for this vitamin supplement. - Ronald C. Gentile, MD, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Director, Ocular Trauma Service, New York Eye and Ear Infirmary of Mount Sinai - John M. Aljian, MD, Associate Clinical Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/890521

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 17, 2018 Date: Wednesday, January 17, 2018 3:13:47 PM Attachments: ATT00001.txt

In the News January 17, 2018

ABC News – January 17 Century After Pandemic, Science Takes Its Best Shot At Flu— Lauran Neergaard A century after one of history’s most catastrophic disease outbreaks, scientists are rethinking how to guard against another super-flu, like the 1918 influenza that killed tens of millions as it swept the globe. There’s no way to predict what strain of the shape-shifting flu virus could trigger another pandemic or, given modern medical tools, how bad it might be. But researchers hope they’re finally closing in on stronger flu shots, ways to boost much-need protection against ordinary winter influenza and guard against future pandemics at the same time. Scientists are trying different tricks to spur production of antibodies. In New York, pioneering flu microbiologist, Peter Palese, PhD, professor and chair of microbiology at the Icahn School of Medicine at Mount Sinai, uses “chimeric” viruses – the hemagglutinin head comes from bird flu, the stem from common human flu viruses – to redirect the immune system. “We have made the head so that the immune system really doesn’t recognize it,” Dr. Palese explained. Still, no one knows the ultimate origin of that terrifying 1918 flu. But key to its lethality was bird-like hemagglutinin. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://abcnews.go.com/Health/wireStory/century-pandemic-science-takes-best-shot-flu-52400174 Additional coverage: American Press http://www.americanpress.com/news/national/century-after-pandemic-science-takes-its-best- shot-at-flu/article_625d401c-fb90-11e7-91ec-2b1f45568403.html Tampa Tribune http://www.tbo.com/news/health/A-century-after-the-1918-pandemic-science-takes-its-best-shot- at-flu_164583593 Tampa Bay Times http://www.tampabay.com/news/health/A-century-after-the-1918-pandemic-science-takes-its- best-shot-at-flu_164583593 Newsmax Health https://www.newsmax.com/health/health-news/flu-shots-universal- vaccine/2018/01/17/id/837618/ National Post http://nationalpost.com/pmn/life-pmn/century-after-pandemic-science-takes-its-best-shot-at-flu Boston Herald http://www.bostonherald.com/lifestyle/health/2018/01/century_after_pandemic_science_takes_its_best_shot_at_flu The Washington Post https://www.washingtonpost.com/national/health-science/century-after-pandemic-science- takes-its-best-shot-at-flu/2018/01/17/176bba8a-fb76-11e7-9b5d-bbf0da31214d_story.html? utm_term=.7b9beef7d7c3

The Independent – January 18 Cocaine Addiction: Scientists Cure Mice Of Dependency On The Drug — Alex Matthews-King Scientists have found that they can decrease appetite for cocaine by neutralizing a protein molecule which is found in the blood and brain at higher levels in repeat cocaine users. This raises the prospect for a safe medication for cocaine addiction by using existing treatments to tackle this biological system driving drug-taking behavior. The protein molecule, G-CSF, affects the reward centers of the brain and could become the first medication to help people beat cocaine addiction according to doctors from the Icahn School of Medicine at Mount Sinai. “The results of this study are exciting because outside of the 12-step programs and psychotherapy, no medication-assisted therapy exists to treat cocaine addictions,” said lead researcher Drew Kiraly, MD, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. The team found that injecting this G-CSF molecule directly into the brain’s reward centers, a region called “nucleus acumbens,” led to a significant increase in the cocaine seeking and consumption behaviors in mice. The finding is important, said Dr. Kiraly, because there are safe treatments already on the market which target this molecule in humans, primarily for kick-starting production of infection fighting cells after chemotherapy. Dr. Kiraly admits there is more work to be done to adapt these findings to humans, but that there is a high possibility of it leading to future treatments. - Drew Kiraly, MD, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.independent.co.uk/news/health/cocaine-addiction-cure-mice-drug-scientists-mount- sinai-new-york-nature-communications-a8162401.html Additional coverage: Yahoo News https://uk.news.yahoo.com/cocaine-addiction-scientists-cure-mice-181706732.html News Medical & Life Sciences https://www.news-medical.net/news/20180116/Cocaine-de-addiction- breakthrough-shows-promise.aspx Health News Digest http://www.healthnewsdigest.com/news/addiction%20issues0/Identify-Protein-Involved-in- Cocaine-Addiction.shtml MedicalHealthNews.net http://www.medicalhealthnews.net/a-breakthrough-edges-scientists-one-step-closer-to- a-cure-for-cocaine-addiction

Medical Health News – January 16 ShangPharma Innovation And Icahn School Of Medicine At Mount Sinai Forge Translational Research Collaboration ShangPharma Innovation Inc., a global venture capital firm focused on biomedical R&D therapeutics and technologies, and the Icahn School of Medicine at Mount Sinai has entered into a multi-year strategic collaboration to accelerate the development of novel early-stage therapeutics. ShangPharma Innovation will provide funding and preclinical research support to further the Icahn School of Medicine at Mount Sinai’s objectives of validating drug targets and establishing programs to discover new therapies. “This partnership was fueled by the groundbreaking technologies from innovators here at Mount Sinai. Our expertise in commercially- relevant translational research, coupled with ShangPharma Innovation’s drug development capabilities will advance much needed medicines to patients worldwide,” said Erik Lium, PhD, senior vice president of Mount Sinai Innovation Partners at the Icahn School of Medicine at Mount Sinai. - Erik Lium, PhD, Senior Vice President, Mount Sinai Innovation Partners, Icahn School of Medicine at Mount Sinai Learn more: http://www.medicalhealthnews.net/shangpharma-innovation-and-icahn-school-of-medicine-at- mount-sinai-forge-translational Additional coverage: KFVS12 News http://www.kfvs12.com/story/37273433/shangpharma-innovation-and-icahn-school-of-medicine- at-mount-sinai-forge-translational-research-collaboration KHQ Right Now http://www.khq.com/story/37273433/shangpharma-innovation-and-icahn-school-of-medicine- at-mount-sinai-forge-translational-research-collaboration Broadway World https://www.broadwayworld.com/bwwgeeks/article/ShangPharma-Innovation-and-Icahn- School-of-Medicine-at-Mount-Sinai-Forge-Translational-Research-Collaboration-20180116 WTOC TV http://www.wtoc.com/story/37273433/shangpharma-innovation-and-icahn-school-of-medicine-at- mount-sinai-forge-translational-research-collaboration NBC 12 http://www.nbc12.com/story/37273433/shangpharma-innovation-and-icahn-school-of-medicine-at- mount-sinai-forge-translational-research-collaboration Fox 14 TV http://www.fox14tv.com/story/37273433/shangpharma-innovation-and-icahn-school-of-medicine-at- mount-sinai-forge-translational-research-collaboration Channel 8 Eyewitness News http://www.klkntv.com/story/37273433/shangpharma-innovation-and-icahn-school- of-medicine-at-mount-sinai-forge-translational-research-collaboration

NBC’s Today Show – January 16 Serena Williams’ Health Scare Prompts National Discussion — Morgan Radford Tennis superstar, Serena Williams, is speaking out about the harrowing post-delivery scare that almost killed her, sparking a discussion that she hopes will lead to change. Williams said she felt short of breath, and because of her history with blood clots, feared she was having a pulmonary embolism. She said it took some convincing to get the CT scan she asked for, but ultimately her suspicion was confirmed. The fact that someone like Williams faced such an ordeal struck a nerve. Elizabeth Howell, MD, MPP, professor of population health science and policy, psychiatry, obstetrics, gynecology and reproductive science, associate dean of academic development and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai said, “Everyone has so much respect for her as an athlete, she has access to care, she has everything, and yet she still suffered one of these events during her delivery hospitalization. It really puts a face to this issue, and an incredibly important one.” American women are more likely to die from childbirth than anywhere else in the developed world. 50,000 women suffer complications during pregnancy every year, and 700 die. The mortality rates for black women are three to four times higher. Some researchers add that poverty and discrimination could play a role in the gap, along with higher rates of chronic illness and obesity, and the quality of medical care many African American women have in their communities. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.today.com/video/serena-williams-health-scare-prompts-national-discussion- 1137916483759 Additional coverage: NBC Nightly News https://www.nbcnews.com/news/nbcblk/maternal-health-statistics-staggering-black-women- n838166

Next Gov – January 16 Don’t Try To Work Through The Flu Of 2018 — Lila MacLellan The flu of 2018 has already been deadly and has led to high rates of hospitalization this year by mid-January versus other years. The difference is that the season has brought more cases of the H3N2 strain of the virus, or influenza A, which was also responsible for a brutal flu season in 2014 and 2015. Public health advocates are urging schools and workplaces to take the flu seriously and to keep it contained as much as possible, which mean sick employees should stay home when symptoms develop. The flu is an issue of your system becoming overloaded. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital said, “You’ve got a lot more mucus production, coughing, et cetera. It sets you up for a possible bacterial infection, such as bacterial pneumonia on top of flu symptoms.” And, though it’s extremely rare, in some people who develop pneumonia, “it will spread to their bloodstream and cause an overwhelming, multi-system infection.” - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://www.nextgov.com/cio-briefing/2018/01/dont-try-work-through-flu-2018/145215/

Science Daily – January 16 Bright Light Therapy Improves Sleep In People Treated For Cancer Results of a randomized controlled trial suggest that systematic bright light exposure can improve sleep for fatigued people who have been treated for cancer. The pilot study results show that mean sleep efficiency, the percentage of time in bed when the person is sleeping, improved to clinically normal levels in the bright light therapy group. "In a pilot study, a systematic light exposure intervention with a mixed group of fatigued cancer survivors was significantly more effective than comparison dim light exposure in improving sleep efficiency," said lead author Lisa M. Wu, PhD, adjunct assistant professor of population health science and policy at the Icahn School of Medicine at Mount Sinai. The study results were published in the Journal of Clinical Sleep Medicine. The research team, led by principal investigator William H. Redd, PhD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai, studied 44 people who had completed treatment for cancer and met criteria for clinically significant fatigue at screening. Participants were randomized to either a bright white light intervention or a comparison dim light condition. They were provided a light box and instructed to use it every morning for 30 minutes for four weeks. Sleep was evaluated using wrist actigraphy and the Pittsburgh Sleep Quality Index. The authors noted that larger-scale studies are needed to test the efficacy of systematic light exposure to treat sleep disturbances in people who have been treated for cancer. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Lisa M. Wu, PhD, Adjunct Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://www.sciencedaily.com/releases/2018/01/180116222500.htm Additional coverage: News Medical & Life Sciences https://www.news-medical.net/news/20180117/Systematic-bright-light-exposure- can-improve-sleep-in-people-treated-for-cancer.aspx Science Codex http://www.sciencecodex.com/bright-light-therapy-improves-sleep-people-treated-cancer-618386

HealthDay – January 17 Sleep Better, Lose Weight? — Dennis Thompson People plagued by insomnia who began sleeping more cut the amount of sugary foods they tended to eat, an experiment at King's College London revealed. U.S. experts said the findings show that sleep can foster healthier eating habits. For the study, researchers recruited 42 people who habitually got less than seven hours of sleep a night. Half of the people received a 45-minute personalized sleep consultation, which provided them with tips to improve their sleep. The goal was to extend their sleep by as much as an hour and a half each night. The other half received no advice and served as the control group. Nearly 9 in 10 of the people who received advice increased their sleep time during the week, anywhere from 52 minutes to about an hour and a half. No significant changes in sleep patterns occurred among those in the control group. Those folks who got more sleep wound up with a 10-gram reduction in their daily intake of added sugars, the researchers found. People with insomnia tend to develop lack of inhibition due to their sleeplessness, said Andrew Varga, MD, PhD, assistant professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. "It just becomes harder to resist certain foods and other things you ordinarily would know you shouldn't indulge in," Dr. Varga said. "You're more likely to act on your base impulses." - Andrew W. Varga, MD, PhD, Assistant Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/sleep-disorder-information-33/insomnia-news-625/sleep-better- lose-weight-730161.html Additional coverage: The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay730161_20180117_Sleep_Better__Lose_Weight_.html Medical Xpress https://medicalxpress.com/news/2018-01-weight.html Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/77810 U.S. News & World Report https://health.usnews.com/health-care/articles/2018-01-17/sleep-better-lose-weight

Vector: Boston Children’s Hospital Blog – January 17 GIANT Study Homes In On Obesity Genes — Nancy Fliesler The largest and most powerful study to date has pinned down 14 variants in 13 genes that carry variations associated with body mass index. They provide new clues as to why some people tend to gain weight and have more trouble losing it. Eight of the variants were in genes not previously tied to human obesity. The study was conducted by the Genetic Investigation of Anthropometric Traits (GIANT) consortium, an international collaboration involving more than 250 research institutions. The study focused on rarer variants in the coding portions of genes, which helped pinpoint causal genes and also helped discover variants with larger effects that those previously discovered by the GIANT consortium. Ruth Loos, PhD, professor of environmental medicine and public health and director of genetics of obesity and related metabolic program at the Charles R. Bronfman Institute of Personalized Medicine at the Icahn School of Medicine at Mount Sinai, co-led the study with Joel Hirschhorn, MD, PhD, a pediatric endocrinologist and researcher at the Boston Children’s Hospital and the Broad Institute of MIT and Harvard. The researchers think the new findings could help focus the search for new therapeutic targets in obesity. - Ruth Loos, PhD, Professor, Environmental Medicine and Public Health, Director, Genetics of Obesity and Related Metabolic Traits Program, Charles R. Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://vector.childrenshospital.org/2018/01/giant-study-identifies-obesity-genes/

Medical News Today – January 17 Why We’re More Likely To Overeat In The Evening — Honor Whiteman Researchers have found that in the evening, we experience alterations in the levels of hormones that influence appetite, which may cause us to overeat. Unsurprisingly, stress and a predisposition to binge eat were also found to increase hunger levels in the evening. But there may be an answer to this problem: eat earlier in the day. The study, conducted by researchers from the Johns Hopkins School of Medicine and the Icahn School of Medicine at Mount Sinai, was recently published in the International Journal of Obesity. The research included 32 adults, aged 18-50 years, who were overweight. Around half of the participants had received a diagnosis of binge eating disorder. The overall aim of this research was to determine how the time of day affects appetite, and whether stress might play a role. “Little is understood about how time of day and stress interact to affect appetite and thereby body weight. This may be particularly important influences in binge eaters, who tend to binge in the evening and in response to stress.” - Icahn School of Medicine at Mount Sinai Learn more: https://www.medicalnewstoday.com/articles/320652.php

TIME – January 17 Can Indoor Plants Really Purify The Air? — Markham Heid Plants are indispensable to human life. Through photosynthesis, they convert the carbon dioxide we exhale into fresh oxygen, and they can also remove toxins from the air we breathe. One famous NASA experiment, published in 1989, found that indoor plants can scrub the air of cancer-causing volatile organic compounds like formaldehyde and benzene. Based on this research, some scientists say house plants are effective natural air purifiers. Other experts say the evidence that plants can effectively accomplish this feat is far from conclusive. “There are no definitive studies to show that having indoor plants can significantly increase the air quality to improve health in a measurable way,” said Luz Claudio, PhD, professor of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai. Dr. Claudio has reviewed the research on the air-quality benefits of indoor plants. She said there’s no question that plants are capable of removing volatile chemical toxins from the air “under laboratory conditions.” But in the real world – in your home, say, or in your office space – the notion that incorporating a few plants can purify your air doesn’t have much hard science to back it up. At this time, it doesn’t look like plants sitting passively in a house are effective enough to make a major contribution to purifying indoor air. - Luz Claudio, PhD, Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: http://time.com/5105027/indoor-plants-air-quality/

Health Magazine – January 16 External Cephalic Version — Julia Naftulin A few weeks prior to being launched into the world, most babies shift into the head-down position in the womb, ready to be delivered vaginally. But the nearly full-term baby Vanessa Fisher was carrying was in the breech position – meaning the baby was positioned with its butt or feet first. After finding out her baby was in breech when she was 28 weeks pregnant, Fisher, a mom of one from Texas, looking into a procedure called external cephalic version – in which a doctor puts manual pressure on the uterus from the outside and turns the baby into a head-down position. “It involves actually physically turning the baby by placing hands on the woman’s uterus to help the baby do somersaults inside the uterus,” said Joanne Stone, MD, professor of obstetrics, gynecology and reproductive medicine and director of maternal-fetal medicine at the Icahn School of Medicine at Mount Sinai. Fisher has yet to give birth, but with her baby in the head-down position, she’s ready to welcome her child into the world via a vaginal delivery, as she’d hoped all along. - Joanne Stone, MD, Professor, Obstetrics, Gynecology and Reproductive Medicine, Director, Maternal-Fetal Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.health.com/pregnancy/doctor-flipped-baby-bump-breech-video

Allure Magazine – January 17 How To Minimize The Appearance Of Stretch Marks — Jennifer Gerson Uffalussy and Loren Savini Chances are, most women you know have stretch marks. If you’re less fond of these little lines, you can minimize their appearance. “Stretch marks are caused by rapid stretching on the skin during times of brisk weight gain, pregnancy or growth,” explained Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetics and clinical research in dermatology at The Mount Sinai Hospital. “The skin stretches so quickly that collagen and elastic tissue is damaged, leading to the characteristic line-like appearance of the skin.” Dr. Zeichner said, “A petroleum-based moisturizer forms a protective seal over the skin and allows your skin to heal optimally, which would minimize the formation of stretch marks.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/how-to-get-rid-of-stretch-marks

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 18, 2018 Date: Thursday, January 18, 2018 12:16:43 PM Attachments: ATT00001.txt

In the News January 18, 2018

Drug Target Review – January 18 G-CSF Protein Involved In Cocaine Addiction — Zara Kassam Researchers have identified a protein produced by the immune system – granulocyte-colony-stimulating- factor (G-CSF) – that could be responsible for the development of cocaine addiction. A study showed that G-CSF can alter a mouse’s desire for cocaine, but not for other rewards. This effect is modulated by a brain region that plays a central role in reward processing and addiction. If applicable to humans, these findings represent a potential therapeutic approach to decrease a cocaine addict’s motivation to seek the drug without introducing a potential new substance for abuse. “The results of this study are exciting because outside of 12-step programs and psychotherapy, no medication-assisted therapy exists to treat cocaine addiction,” said the study’s senior author, Drew Kiraly, MD, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. “Drugs that manipulate G-CSF already exist as FDA-approved medications. Once we clarify how G-CSF signaling can best be targeted to reduce addiction-like behaviors, there is a high possibility that treatments targeting G-CSF could be translated into clinical trials and treatments for patients.” - Drew Kiraly, MD, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.drugtargetreview.com/news/28855/g-csf-protein-involved-in-cocaine- addiction/ Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/18/28th-times-the-charm-025437

ABC World News Tonight – January 17 New Flu Fears: Deadly Epidemic Hitting Communities Hard— Gio Benitez The fast moving flu is claiming the young and strong. A ten year old from Connecticut tested positive for the flu and was released, but before he made it back home, he grew sicker and was rushed to another hospital where he later died from pneumonia and sepsis. “Sometimes things happen, and it could be because somebody has an additional condition that we aren’t aware of. If you’re developing very high fevers, if you’re not able to keep down any food or drink, if you become light headed, you really should go back to the emergency room,” said Erick Eiting, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and director of emergency medicine and urgent care at Mount Sinai Downtown. Doctors using rapid tests at urgent care centers like Mount Sinai are getting results in just five minutes. - Erick Eiting, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Medicine and Urgent Care, Mount Sinai Downtown Learn more: http://abc.go.com/shows/world-news-tonight/episode-guide/2018-01/17-011718-at-least-8- have-died-on-slippery-roads-from-gulf-coast-to-northeast

Laboratory Equipment – January 17 Bright Light Therapy Improves Sleep In People Treated For Cancer Results of a randomized controlled trial suggest that systematic bright light exposure can improve sleep for fatigued people who have been treated for cancer. The pilot study results show that mean sleep efficiency, the percentage of time in bed when the person is sleeping, improved to clinically normal levels in the bright light therapy group. "In a pilot study, a systematic light exposure intervention with a mixed group of fatigued cancer survivors was significantly more effective than comparison dim light exposure in improving sleep efficiency," said lead author Lisa M. Wu, PhD, adjunct assistant professor of population health science and policy at the Icahn School of Medicine at Mount Sinai. The study results were published in the Journal of Clinical Sleep Medicine. The research team, led by principal investigator William H. Redd, PhD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai, studied 44 people who had completed treatment for cancer and met criteria for clinically significant fatigue at screening. Participants were randomized to either a bright white light intervention or a comparison dim light condition. They were provided a light box and instructed to use it every morning for 30 minutes for four weeks. Sleep was evaluated using wrist actigraphy and the Pittsburgh Sleep Quality Index. The authors noted that larger-scale studies are needed to test the efficacy of systematic light exposure to treat sleep disturbances in people who have been treated for cancer. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Lisa M. Wu, PhD, Adjunct Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://www.laboratoryequipment.com/news/2018/01/bright-light-therapy-improves-sleep- people-treated-cancer

MSN News – January 18 Seven Signs Of Lung Cancer You Might Be Ignoring — Alyssa Jung Lung cancer is the leading cause of cancer deaths in both men and women. Treatment is more effective the earlier lung cancer is diagnosed, so see your doctor if you notice any of the following lung cancer symptoms. “Coughing up blood is never a good sign. Right then and there, go see your doctor,” said Raja Flores, MD, professor of thoracic surgery, director of the thoracic surgical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and system chair of thoracic surgery at the Mount Sinai Health System. Although cancer may not necessarily be the cause of your bloody coughs, you should definitely get tested, he said. If you feel rundown but haven’t made any changes to your daily routine, it could be a sign of cancer. “It may not specifically signal lung cancer, but it’s a definite red flag that something is not right,” said Dr. Flores. - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://www.msn.com/en-ca/health/ads-aol-lungcancer/7-signs-of-lung-cancer-you-might- be-ignoring/ss-AAoPFs7?li=AAggV0S&srcref=rss

HealthDay – January 17 Morning Sickness Drug May Not Work — Dennis Thompson The most commonly prescribed medicine for morning sickness may not work, a new report contends. The drug, Diclegis, failed to meet minimum effectiveness goals in the clinical trial relied upon by the U.S. Food and Drug Administration for its approval in 2013, Canadian researchers reported. Diclegis is the combination of an antihistamine, doxylamine succinate, with a form of vitamin B6 called pyridoxine hydrochloride. But lawsuits related to those claims were eventually dismissed, and efforts began in the 2000s to get the drug back onto the U.S. market. The drug has always been available in Canada and is currently sold there as Diclectin. Given how well the drug has worked in practice, the new paper is "much to do about nothing," said Fahimeh Sasan DO, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. No one would argue that it was a very small study, and that the improvement in symptoms didn't reach the benchmark initially set, Dr. Sasan said. But in everyday life the drug has proven very effective, said Dr. Sasan, who works at a "very bustling, busy" obstetrics practice on the Upper East Side of Manhattan that performs 750 to 800 deliveries a year. "It's safe, and within our practice we are finding that women only have to take it once a day," Dr. Sasan said, adding that other nausea/vomiting drugs require multiple daily doses and come with more significant side effects. - Fahimeh Sasan, DO, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/pregnancy-information-29/pregnancy-risks-news- 546/morning-sickness-drug-may-not-work-study-730224.html Additional coverage: U.S. News & World Report https://health.usnews.com/health-care/articles/2018-01-17/morning-sickness- drug-may-not-work-study

The Huffington Post – January 17 The Best Way To Pop A Pimple Safely, According To Dermatologists — Julia Brucculieri When it comes to caring for your skin, popping pimples is a huge no-no. Yet even though we’re told we’re not supposed to do it, we all pop our zits from time to time. If you just can’t stop popping your own zits, there are some things dermatologists want you to keep in mind. You need to make sure the area and your hands are cleaned thoroughly. “If a pimple has a clear ‘whitehead’ then you can wash your hands and wash the area with soap and water and gently apply pressure from both sides,” said Angela Lamb, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of the Westside Mount Sinai Dermatology Faculty Practice. Dr. Lamb also suggested using warm compresses to bring the inflammation to a head and generally open up the pore. She said the best and safest thing to do is wait it out and see a professional. - Angela Lamb, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Westside Mount Sinai Dermatology Faculty Practice Learn more: https://www.huffingtonpost.com/entry/how-to-pop-a-pimple_us_5a5e3a95e4b0fcbc3a13f109

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 19, 2018 Date: Friday, January 19, 2018 2:00:45 PM Attachments: ATT00001.txt

In the News January 19, 2018

CBS News – January 18 100 Years After ‘Super Flu’ Pandemic Killed Millions, Universal Vaccine Remains Elusive A century after one of history’s most catastrophic disease outbreaks, scientists are rethinking how to guard against another super-flu, like the 1918 influenza that killed tens of millions as it swept the globe. There’s no way to predict what strain of the shape-shifting flu virus could trigger another pandemic or, given modern medical tools, how bad it might be. But researchers hope they’re finally closing in on stronger flu shots, ways to boost much-need protection against ordinary winter influenza and guard against future pandemics at the same time. Scientists are trying different tricks to spur production of antibodies. In New York, pioneering flu microbiologist, Peter Palese, PhD, professor and chair of microbiology at the Icahn School of Medicine at Mount Sinai, uses “chimeric” viruses – the hemagglutinin head comes from bird flu, the stem from common human flu viruses – to redirect the immune system. “We have made the head so that the immune system really doesn’t recognize it,” Dr. Palese explained. Still, no one knows the ultimate origin of that terrifying 1918 flu. But key to its lethality was bird-like hemagglutinin. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.cbsnews.com/news/100-years-after-flu-pandemic-scientists-seek-universal- vaccine/ Additional coverage: WKOW http://www.wkow.com/story/37290644/2018/01/17/researchers-closing-in-on-universal-flu- vaccine

Medical Research – January 18 Bright Light Exposure Improved Sleep In Cancer Patients — Marie Benz, MD Sleep disturbances are reported by cancer patients at a significantly higher rate than in the general population. Among post-treatment cancer patients, 23 to 44 percent experience insomnia symptoms even years after treatment. Sleep disturbances are most commonly treated with medications which many cancer patients are reluctant to add to the large group of medications already prescribed. Furthermore, systematic light exposure intervention is less burdensome than other non-pharmacologic interventions for sleep disturbance. Lisa M. Wu, PhD, adjunct assistant professor of population health science and policy at the Icahn School of Medicine at Mount Sinai, lead author of the manuscript said, “Systematic light exposure using bright white light is a low cost and easily disseminable intervention that offers a feasible and potentially effective alternative to improve sleep in cancer survivors, particularly for those who are fatigued.” William H. Redd, PhD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai was the principal investigator of the study itself that was conducted at Mount Sinai Health System. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Lisa M. Wu, PhD, Adjunct Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://medicalresearch.com/cancer-_-oncology/bright-light-exposure-improved-sleep-in- cancer-patients/39363/

Amsterdam News – January 18 New Cancer Treatment Facility To Open In East Harlem — Stephen Johnson New York State doesn’t have an advanced cancer treatment facility. That changes in 2019. Currently under construction, the New York Proton Center will serve close to 1,500 patients annually using targeted radiation and bean therapy to combat pediatric, head, neck, and eye cancers. NYPC would be the 26th proton beam therapy facility in the country. The NYPC will be operated by found New York-based health care institutions: The Memorial Sloan Kettering Cancer Center, The Mount Sinai Health System, The Montefiore Health System, and ProHEALTH Proton Management, LLC. NYPC’s development is part of the NYCEDC’s East 125th Street Development plan that includes affordable housing, jobs, tech and medical innovation. - Mount Sinai Health System Learn more: http://amsterdamnews.com/news/2018/jan/18/new-cancer-treatment-facility-open-east- harlem/

U.S. News & World Report – January 19 The Doctor Will See You Today — Lisa Esposito Appointment wait times are on the rise. Patients wait an average of 24 days for a new physician appointment in major metropolitan areas. However, some medical practices now offer same-day appointments on request. About a year ago, Mount Sinai Health System began offering same-day appointments across a wide range of specialties. “We recognize in this day and age of health care or any other field, there are many people who want service when they want it, and often it’s on that day,” said Abraham L. Warshaw, MD, associate professor of population health science and policy at the Icahn School of Medicine at Mount Sinai, chief and medical director of access services, and senior vice president of the Mount Sinai Health System. Same-day care means more than just squeezing in acutely ill patients, Dr. Warshaw emphasizes. The approach encompasses a wide range of needs, from patients concerned about ongoing headaches to those newly diagnosed with a frightening condition, like cancer, in search of a second opinion. “We’re able to look into the schedules of a lot of our doctors and make use of a broad capacity that the health system has throughout the city and surrounding areas,” Dr. Warshaw said. Same- day appointments may encourage reluctant patients to seize the moment, he suggested: “We’ve been pleasantly surprised by the people who say, ‘Today is the day I finally want to see a primary care provider. I want to move my health care along.’” - Abraham L. Warshaw, MD, Associate Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Chief, Medical Director, Access Services, Senior Vice President, Mount Sinai Health System Learn more: https://health.usnews.com/health-care/patient-advice/articles/2018-01-19/the-doctor-will-see- you-today

Healio – January 18 Possible Genetic Link Found Between Crohn’s, Parkinson’s In Jewish Population — Alex Young Patients with Crohn’s disease who are of Ashkenazi Jewish ancestry are more likely to carry a genetic mutation previously correlated with Parkinson’s disease, according to a study published in Science Translational Medicine. Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and colleagues wrote the discovery of a link between Crohn’s disease and mutations to the LRRK2 gene could have implications on the future treatment of the disease. “The study’s findings could help doctors better understand Crohn’s disease, identify individuals who are at risk, and develop new drugs for treatment and/or prevention by targeting this specific gene,” Dr. Peter said. Identifying the protective mutation could be a pivotal discovery for researchers and should spur further investigation, added Dr. Peter. “Naturally occurring protective mutations are important, because they could serve as targets for potentially new therapies,” she said. “Therefore, drugs targeting the pathways associated with the effects of the protective mutation should be immediately explored. The other next step would be to better understand the biology of the risk mutation and design drugs that can mitigate its effects.” - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/gastroenterology/inflammatory-bowel- disease/news/online/%7B21efeba2-bd3f-438f-b895-b67099528c1a%7D/possible-genetic-link-found- between-crohns-parkinsons-in-jewish-population

A Sweat Life – January 15 How To Prep For Winter Sports — Sarah Grossbart Every winter, Alexis Colvin, MD, associate professor of sports medicine and orthopaedics at the Icahn School of Medicine at Mount Sinai, braces herself for the onslaught. Come January, like clockwork, patients begin limping into the hospital, complaining of knee injuries. She attributes the spike in ACL and meniscus tears to so-called weekend warriors hitting the slopes with little to no advanced training. “The most common scenario is someone who may or may not work out much during the week, and then they go skiing for the weekend and do pretty intense days,” explained Dr. Colvin. “And it’s almost always toward the end of the day, where they just want to squeeze one last run in and they maybe weren’t paying attention as much and then they injure the knee.” Dr. Colvin suggests hobby skier spend four to six weeks conditioning before they hit the slopes. “Working on your cardio, flexibility, and core strengthening can help prevent injury,” she said. Whether you’re taking on an outdoor adventure sport or joining an in-town winter sports league, following these tips will help you stay healthy all season long. - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: https://asweatlife.com/2018/01/prep-for-winter-sports/

Blasting News – January 18 Veganism Reaches Record High, Learn Why — Kirsty Tuxford Major food chains are now offering vegan options due to soaring demand. Veganism is, without doubt, a growing global trend as people choose to eat a plant-based diet for both health and ethical reasons. Awareness about the health benefits is a key driver in the public’s switch to vegan. The Icahn School of Medicine at Mount Sinai studied 15,569 participants and discovered that people who ate a plant-based vegan diet were 42 percent less likely to suffer from heart failure. A vegan diet can help to protect bone and heart health, and lower the risk of cancer. A number of U.S. hospitals are removing processed meat from their menus and adding healthy vegan meals. A recent report is claiming that six percent of U.S. citizens now call themselves vegan – an enormous increase of 600 percent over three years. - Icahn School of Medicine at Mount Sinai Learn more: http://us.blastingnews.com/lifestyle/2018/01/veganism-reaches-record-high-learn-why- 002298551.html

Women’s Health – January 18 Seven Brain Cancer Symptoms Every Woman Should Know About — Ashley Mateo Brain cancer: That’s a really scary term. Luckily, there’s a less than one percent chance you’ll develop a malignant brain or spinal tumor in your life, according to the American Cancer Society. Still, the ACS estimates that about 23,880 cases of brain cancer will be diagnosed in 2018. Brain cancer comes in two varieties: Primary tumors, which start in the brain and rarely spread, and secondary tumors, which start elsewhere in the body, typically the lungs or breasts, and spread to the brain, said Adilia Hormigo, MD, PhD, associate professor of neurology and neurosurgery at the Icahn School of Medicine at Mount Sinai and director of the neuro-oncology program at the Mount Sinai Health System. Over time, brain cancer can impact surrounding brain cells to seriously compromise brain function. And while that’s true of all brain tumors, malignant or benign, cancerous tumors are more likely to spread throughout the brain, and quickly, according to Dr. Hormigo. That’s why malignant tumors require aggressive treatments, typically including surgery, radiation, and/or chemotherapy, she said. “If you have any symptoms that could indicate a brain tumor, you should go to your primary care doctor or internist as soon as possible,” said Dr. Hormigo. “They can guide you to the right specialist.” - Adilia Hormigo, MD, PhD, Associate Professor, Neurology, Neurosurgery, Medicine, Icahn School of Medicine at Mount Sinai, Director, Neuro-Oncology Program, Mount Sinai Health System Learn more: https://www.womenshealthmag.com/health/brain-cancer-symptoms

Health – January 18 I Sleep Well, Eat Healthy, and Exercise. So Why Am I Always Getting Sick? — Jacqueline Andriakos It is possible that some people have naturally stronger immune systems than others. Some individuals are thought to be especially resistant to certain bacterial and viral infections. Your immunity is determined by several factors. Genetics play a large role, said Paolo Bofetta, MD, professor of hematology and medical oncology at the Icahn School of Medicine at Mount Sinai. “Immunological genes are many and complex, and your immune response depends on their combined performance,” Dr. Boffetta explained. Experts also believe that you build up immunity while you are young, or possibly even before you are born. “There are factors during infancy and childhood, and perhaps also in utero, that contribute to the development of the immune system, but they are not fully understood,” said Dr. Boffetta. What’s more, environmental factors, such as pollutants and toxins, may also weaken your immune system over time. - Paolo Boffetta, MD, Professor, Hematology, Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: http://www.health.com/cold-flu-sinus/healthy-immune-system-tips

AccuWeather – January 19 Why Are Cold Sores More Likely To Manifest In The Winter? — Jennifer Fabiano Due to trigger factors related to colder weather, cold sores are more likely to manifest in the winter, according to Erick Eiting, MD, professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and director of emergency medicine and urgent care for Mount Sinai Downtown. “It’s something that I don’t often think about, but it’s true it definitely happens more around this season,” Dr. Eiting said. Cold sores are fluid-filled blisters that appear on or around the lips that are caused by a herpes simplex virus. The virus is highly contagious and is spread easily from person to person through contact. Dr. Eiting stressed that using appropriate hydrating lip palms and facial moisturizers is important in preventing cold sore outbreaks. “The air in the winter is colder and drier, and that’s why we get chapped lips and drier skin,” Dr. Eiting explained. “All of those just make it easier for stress responses to get triggered.” Dr. Eiting also recommends taking a daily multi-vitamin to ensure that you are receiving adequate levels of vitamins that you may be getting less of in the winter, including vitamins C and D. - Erick Eiting, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Director, Emergency Medicine and Urgent Care, Mount Sinai Downtown Learn more: https://www.accuweather.com/en/weather-news/why-are-cold-sores-are-more-likely-to- manifest-in-the-winter/70003849

Reader’s Digest – January 18 Eight Proven Treatments For Plaque Psoriasis — Denise Mann, MS This skin condition is the most common type of psoriasis, and it causes raised, red patches covered with silvery scales. If plaque psoriasis covers less than ten percent of your body, it’s considered mild. In these cases, topical treatments tend to be the best bet, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. Steroids are among the most widely prescribed topical treatment for plaque psoriasis. They work by reducing the inflammation that fuels the condition. There are several non-biologic medications that can help treat plaque psoriasis. One, Otezla, is extremely effective for moderate plaque psoriasis, Dr. Goldenberg said. It’s a pill – in injection necessary – that inhibits an enzyme linked to inflammation. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.rd.com/health/conditions/plaque-psoriasis-treatments/

Yahoo News – January 18 Should You Get A Tattoo Made With Motorcycle Exhaust? — Sabrina Rojas Weiss Now that tattoos are about as mainstream as it gets, there are people searching for ways to make their body art just a little bit more unusual. People are now getting tattoos from Indian Motorcycle Ink, made with the exhaust from a motorcycle. Only ten bottles of Indian Motorcycle Ink have been made, and they won’t make it again. But if there’s a demand for it, other ink makers might decide to copy the idea. “Taking something from the exhaust of a motorcycle and injecting it with a tiny needle into your body – to me that doesn’t sound like a smart idea,” said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at The Mount Sinai Hospital. At issue is the host of unknowns involved in putting an untested chemical into the sin. “It’s not just about the substance itself; sometimes when you put chemicals together, one plus one doesn’t equal two,” he added. “You can have a reaction that you may not have with just one chemical.” If you are allergic, or if you simply regret your tattoo, the unknown also affect whether you can get it removed. “Technology to do tattoo removal is actually quite good, but that technology works best if pigment is something that the laser recognizes,” Dr. Goldenberg said. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.yahoo.com/lifestyle/get-tattoo-made-motorcycle-exhaust-222856641.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 22, 2018 Date: Monday, January 22, 2018 12:55:53 PM Attachments: ATT00001.txt

In the News January 22, 2018

Town & Village – January 19 Stuyvesant Town Mount Sinai Practice Open Mount Sinai Doctors Stuyvesant Town, a new multi-specialty practice, was officially opened with a ribbon-cutting ceremony. Featuring state-of-the-art exam rooms and imaging services, the practice will offer extended weekday and weekend hours for both walk-in and scheduled appointments. “Serving the downtown community is our top priority and our vast ambulatory network, one of the largest in lower Manhattan, makes this possible,” said Jeremy Boal, MD, president of Mount Sinai Downtown and chief medical officer of the Mount Sinai Health System. Stuyvesant resident Monica Inzio, a patient, said she has been “eagerly waiting” for the practice to open. “It’s great to know that it’s a practice and walk-in emergency clinic in one,” said Inzio. - Jeremy Boal, MD, President, Mount Sinai Downtown, Chief Medical Officer, Mount Sinai Health System Learn more: https://town-village.com/2018/01/19/stuyvesant-town-mount-sinai-practice-now-open/

New York Magazine – January 19 The Birth Plan Of A Black Woman — Ashley Stoney For black women, dying of childbirth transcends socioeconomic factors. Doctors may reflexively categorize educated, middle-class or affluent Black women as low risk and overlook red flags. This is precisely what we saw happen to Serena Williams, as she recounts having to push for critical, life-saving treatment after giving birth. Harrowing statistics have stood out recently. Cities where housing is still very segregated – such as Washington, D.C. and New York City – have some of the nation’s widest racial disparities for maternal health. One study co-authored by Elizabeth Howell, MD, MPP, professor of population health science and policy, obstetrics, gynecology and reproductive science, and director of the Women’s Health Institute at the Icahn School of Medicine at Mount Sinai, suggests that Black women are more likely to deliver in lower-quality hospitals. Several factors, including genetic predispositions, chronic stress, racial bias and structural barriers to health care impact the stark disparity in maternal deaths by race in this country. - Elizabeth Howell, MD, MPP, Professor, Population Health Science and Policy, Psychiatry, Schizophrenia, Obstetrics, Gynecology and Reproductive Science, Associate Dean, Academic Development, Director, Women’s Health Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.thecut.com/2018/01/being-pregnant-and-planning-to-give-birth-while- black.html

TIME – January 19 Scientists Seek Universal Flu Shot 100 Years After Deadly Pandemic— Lauran Neergaard A century after one of history’s most catastrophic disease outbreaks, scientists are rethinking how to guard against another super-flu, like the 1918 influenza that killed tens of millions as it swept the globe. There’s no way to predict what strain of the shape-shifting flu virus could trigger another pandemic or, given modern medical tools, how bad it might be. But researchers hope they’re finally closing in on stronger flu shots, ways to boost much-need protection against ordinary winter influenza and guard against future pandemics at the same time. Scientists are trying different tricks to spur production of antibodies. In New York, pioneering flu microbiologist, Peter Palese, PhD, professor and chair of microbiology at the Icahn School of Medicine at Mount Sinai, uses “chimeric” viruses – the hemagglutinin head comes from bird flu, the stem from common human flu viruses – to redirect the immune system. “We have made the head so that the immune system really doesn’t recognize it,” Dr. Palese explained. Still, no one knows the ultimate origin of that terrifying 1918 flu. But key to its lethality was bird-like hemagglutinin. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://time.com/5109910/flu-shot-influenza-pandemic/ Additional coverage: Modern Healthcare http://www.modernhealthcare.com/article/20180119/NEWS/180119898

NBC News – January 19 The Search For A Better Flu Vaccine— Kristen Dahlgren Across the country, the flu is hitting hard and fast, young and old, even previously healthy people are dying. According to the CDC, 78 percent of samples tested this year have been the most aggressive of the four known flu strains – H3N2. “Our vaccine is probably least effective against H3N2, slightly less vaccine immunity and slightly more aggressiveness, it ends up being a bad year,” said Nicole M. Bouvier, MD, associate professor of medicine, infectious diseases and microbiology at the Icahn School of Medicine at Mount Sinai. The Mount Sinai Hospital is one of the places looking for a vaccine that covers all strains and mutations. “The flu is always changing, and we need about six months to make a vaccine,” added Dr. Bouvier. The National Institutes of Health has designated a so-called super vaccine a top priority. One vaccine you wouldn’t have to get every year is being tested, but could still be five to ten years away. For now, the CDC is pushing the vaccine it does have, and a lot of hand washing. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnews.com/nightly-news/video/the-search-for-a-better-flu-vaccine- 1140237891837

ABC News: Good Morning America – January 22 How To Limit The Risk Of Flu In Your Home— Gio Benitez Right now, doctors are seeing the most visits they have seen due to flu-like illnesses in nearly a decade. With at least 30 flu-related deaths reported in kids this season alone, and with many families stuck inside, correspondent, Gio Benitez set out to see what you can do to make your home a germ-proof zone. They went to the home of mother of two, Liz Samuel, and brought along Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital. “If someone is sick, they’re sneezing and coughing, they are going to be shedding viral particles everywhere, they should be kept away from other kids,” Dr. Shearer said. To flu proof a home you should have “frequent hand washing and clean the hard surfaces with something that has some anti-viral cleaning qualities to it,” added Dr. Shearer. Dr. Shearer said gargling green tea could help kill the virus. “The studies that they have done on this have not been very large studies, but it also carries very little risk and is low cost,” Dr. Shearer explained. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://abcnews.go.com/GMA/video/limit-risk-flu-home-52519432 Additional coverage: News Reality http://www.newsreality.com/post/watch-how-to-limit-the-risk-of-flu-in-your-home.html

The Washington Post – January 21 When Kids Come In Saying They Are Transgender, These Doctors Try To Help— Sara Solovitch Jacob Bilstein, at 13 years old, informed his mother, Jennifer, he felt he was born into the wrong gender. Now, the two sat in an examination room at the University of California at San Francisco, or UCSF. As they navigate the rough shoals of the Trans life, the Bilsteins are putting their hopes in the Child and Adolescent Gender Center at UCSF. Founded in 2012, it is one of 40 or so such clinics around the country, seeing patients as young as three and as old as 25. Since opening, the center has seen close to 700 patients. The type of services being requested has also change. Clinicians say they are no longer taken aback by youths seeking some kind of boutique treatment. In fact, the entire medical field is playing catch-up. Last summer, the Mount Sinai Health System awarded two medical fellowships – the first of their kind in the United States – in transgender surgery and transgender psychiatry. - Mount Sinai Health System Learn more: https://www.washingtonpost.com/national/health-science/when-kids-come-in-saying-they- are-transgender-or-no-gender-these-doctors-try-to-help/2018/01/19/f635e5fa-dac0-11e7-a841- 2066faf731ef_story.html?utm_term=.bfa8e98c9670

Ophthalmology Times – January 2018 Lens Fragmentation Device Is In The Loop — Cheryl Guttman Krader Mechanical micro-interventional lens fragmentation using a proprietary device, miLoop, has the potential to improve phacoemulsification efficiency, control, and safety in all cataract surgery, and particularly for the challenging cases that involve very dense nuclei. The device represents an extension of other micro- interventional concepts in ophthalmology, said Sean Ianchulev, MD, MPH, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and director of the ophthalmic innovation and technology program at the New York Eye and Ear Infirmary of Mount Sinai, who developed the device. “Through our experience in microinvasive glaucoma surgery, we realized that some of the techniques being used in cardiovascular surgery and interventional radiology were quite pertinent to ophthalmology,” said Dr. Ianchulev. “The hope is to take their expression further to create better tools that can guide us toward breaking new grounds in our surgical approach.” He added that, “our patients demand ever less traumatic and minimally invasive solutions for immediate refractive outcomes.” - Sean Ianchulev, MD, MPH, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Director of the Ophthalmic Innovation and Technology Program, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://ophthalmologytimes.modernmedicine.com/sites/default/files/images/digital/OT/OT010118_ezine.pdf Additional coverage: Cataract & Refractive Surgery Today https://crstoday.com/articles/2017-nov-dec/the-new-and-the- noteworthy/

Medical Xpress – January 22 Speech Analysis Software Predicted Psychosis In At-Risk Patients With Up To 83 Percent Accuracy Computer-based analyses of speech transcripts obtained from interviews with at-risk youths were able to predict which youths would later develop psychosis within two years, with an accuracy of up to 83 percent. In two independent cohorts of young people at risk for psychosis, a disturbance in the flow of meaning when speaking, other-wise known as being tangential or going off track, predicted who would later develop psychosis. The results of the study were published in World Psychiatry. "The results of this study are exciting because this technology has the potential to improve pre-diction of psychosis and ultimately help us prevent psychosis by helping researchers develop re-mediation and training strategies that target the cognitive deficits that may underlie language disturbance," said the study's first author, Cheryl Corcoran, MD, senior faculty of psychiatry and program leader in psychosis risk at the Icahn School of Medicine at Mount Sinai. "More broadly, language and behavior are the primary sources of data for psychiatrists to diagnose and treat mental disorders," said Dr. Corcoran. "There are now novel computerized methods to characterize complex behaviors such as language. Speech is easy to collect and inexpensive to analyze using computer-based analysis. This technology could be applied across psychiatry, and plausibly in other fields of medicine." - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-01-speech-analysis-software-psychosis-at-risk.html

NBC News – January 22 New Approach To Abdominal Aortic Aneurysm Saves Lives — Parminder Deo, Lauren Dunn, & Shamard Charles, MD A hidden, often deadly heart condition with no clear known cause nearly killed 54-year-old Gina Berg two years ago. If not for a new surgical technique, a minimally invasive produce which uses 3D printing technology, the adventurous Berg might never have been able to return to her passions of traveling, snorkeling, and cooking. Berg was rushed to the hospital after experiencing a major heart attack in her car. But the heart attack wasn’t the only danger. After a series of tests, the doctors made a shocking discovery. Parts of her aorta, the largest blood vessel in the body, were so enlarges that it could rupture at any moment. The deadly condition is called abdominal aortic aneurysm, and Berg had not one but two of them – measuring 5 centimeters and 6.5 centimeters wide – making surgery dangerous. “The use of 3D printing to personalize aortic repair is fascinating,” said Ramesh Gowda, MD, director of endovascular services and associate director of interventional cardiology at Mount Sinai Beth Israel. “Every patient differs in their aortic anatomical geometry so it can be hard to precisely ascertain the perfect sized graft, despite advances in CT imaging techniques, but newer patient-specific 3D printed models may circumvent these challenges.” The cardiology community now prefers the endovascular approach. - Ramesh Gowda, MD, Director, Endovascular Services, Associate Director, Interventional Cardiology, Mount Sinai Beth Israel Learn more: https://www.nbcnews.com/health/health-news/new-approach-abdominal-aortic-aneurysm- repair-leads-quicker-recovery-n839251

NY 1 News – January 22 The Trend Of Ingesting Tide Pods — Erin Billups A dangerous new trend is making its way across the internet, the Tide Pod Challenge, dares kids to eat the detergent. This is a troubling and widely criticized challenge because ingesting the contents of these Tide Pods could lead to chemical burns in the mouth and even death, if left untreated. “Whenever you put these pods in your mouth, you could have oral airway irritation, irritation to the back of your throat all the way to the back of your airway, and to your esophagus, that can compromise your breathing and swallowing mechanisms” said Ruben Olmedo, MD, associate professor of emergency medicine and director of the division of toxicology at the Icahn School of Medicine at Mount Sinai. Dr. Olmedo has been teaching his medical students what to do if a patient has ingested a Tide Pod. He said parents should call 911, especially if their child is having trouble breathing, but he said to not give them water and do not make them throw up. “We don’t know exactly how much injury this has caused in your airway, so giving them anything to drink might worsen that or might induce vomiting, that we don’t want,” Dr. Olmedo said. Health officials are urging parents to keep the pods locked up and away from their children. - Ruben E. Olmedo, MD, Associate Professor, Emergency Medicine, Director, Division of Toxicology, Director, Customer Service and Wellness, Icahn School of Medicine at Mount Sinai Learn more: No link available.

Healio – January 19 Diabetes, High BMI Cause Nearly Six Percent Of Cancers Worldwide — Regina Schaffer Approximately 5.6 percent of all incident cancers in 2012 were attributable to the combined effects of diabetes and high BMI as independent risk factors, according to a new analysis published in The Lancet Diabetes & Endocrinology. “This meta-analysis thoughtfully adds to prior research implicating the role of high BMI and diabetes as independent and combined risk factors, given possible overlap,” said Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bones disease and director of the weight and metabolism management program at the Icahn School of Medicine at Mount Sinai. She added that as a female endocrinologist and weight-management specialist, I find it intriguing that high BMI and diabetes affect a woman’s risk of cancer greater than a man’s, and that the prevalence of such cancer’s associated with these risk factors varies so much by region. “In my practice, most patients are motivated to lose weight to reduce their risk for diabetes, heart disease, stroke and other metabolic complications. But this study supports the need to start counselling our overweight and obese patients about their increased risk for cancer,” Dr. Srinath said. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/endocrinology/diabetes/news/in-the-journals/%7bb90ef9ec-1697- 4c43-bedf-817df6b94cee%7d/diabetes-high-bmi-cause-nearly-6-of-cancers-worldwide

CNBC News – January 21 Women Rushed To Get IUDs Fearing Trump’s Threats To Repeal Obamacare — Angelica LaVito The IUD business is booming in the age of Trump. At least 134,285 women have seen a doctor for an IUD prescription or insertion since Donald Trump was elected president, a 16 percent increase from the year before, according to data from Athenahealth. The law, commonly known as Obamacare, mandates insurers cover the cost of contraceptives, including intrauterine devices, or IUDs. Adam Jacobs, MD, associate professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and medical director in the division of family planning at Mount Sinai Health System saw an uptick after the election. He remembers some patients coming in and saying they have been considering getting an IUD and weren’t completely sure beforehand but figured they ought to do it before they might lose coverage. However, Dr. Jacobs noted that IUD insertions were already on the rise before Trump entered the political scene. More doctors recommend IUDs as the standard contraceptive because they last longer and are shown to be more effective, he said. - Adam Jacobs, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, Pediatrics, Medical Education, Icahn School of Medicine at Mount Sinai, Medical Director, Division of Family Planning, Mount Sinai Health System Learn more: https://www.cnbc.com/2018/01/21/donald-trump-iud-bump-trends-mirror-obamacare- repeal-efforts.html

Women’s Health –January 5 Why The DASH Diet Is Named The #1 Overall Best Diet Every Year — Ashley Mateo DASH – which stands for Dietary Approaches to Stop Hypertension – is far from a fad diet. Created by the National Heart, Lung, and Blood Institute, the DASH Diet is designed to improve health in people with high blood pressure. In the U.S., one out of every three adults has high blood pressure, according to the Centers of Disease Control and Prevention. U.S. News & World Report has named the DASH Diet the best overall diet for the past eight years. That’s because the DASH Diet has been proven to work, said Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bones disease and director of the weight and metabolism management program at the Icahn School of Medicine at Mount Sinai. One study found that people who followed the DASH Diet had lower blood pressure and LDL cholesterol levels than those who consumed a typical American diet or and American diet infused with extra fruits and veggies. And while the diet wasn’t designed with weight loss as a primary goal, it’s no secret that many of the nutritional factors that influence blood pressure also influence weight, she said. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/weight-loss/dash-diet

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 23, 2018 Date: Tuesday, January 23, 2018 1:55:04 PM Attachments: ATT00001.txt

In the News January 23, 2018

United Press International – January 22 Speech Analysis Can Predict Psychosis In At-Risk Youths — Allen Cone Analysis of speech may help predict which at-risk youths will develop psychosis within two years, researchers suggest in a new study. In the research of two independent groups, the method was about 80 percent accurate in determining whether youths whose speech was tangential, or going off track, led to psychosis, according to a study published in the journal World Psychiatry. "Language and behavior are the primary sources of data for psychiatrists to diagnose and treat mental disorders," said the study's first author, Cheryl Corcoran, MD, senior faculty of psychiatry and program leader of psychosis risk at the Icahn School of Medicine at Mount Sinai. "There are now novel computerized methods to characterize complex behaviors such as language. Speech is easy to collect and inexpensive to analyze using computer-based analysis. This technology could be applied across psychiatry, and plausibly in other fields of medicine." She added that the results of this study are exciting because “this technology has the potential to improve prediction of psychosis and ultimately help us prevent psychosis by helping researchers develop re-mediation and training strategies that target the cognitive deficits that may underlie language disturbance.” Dr. Corcoran recently received a grant to test the method on a much larger risk group, which she said will also include non-English speakers. - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: https://www.upi.com/Health_News/2018/01/22/Speech-analysis-can-predict-psychosis-in-at- risk-youths-Study/3201516636928/ Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/23/cuomo-eyes-insurance-reserves-026582 Science Daily https://www.sciencedaily.com/releases/2018/01/180122104013.htm News Medical & Life Sciences https://www.news-medical.net/news/20180122/Computer-based-speech- analysis-has-potential-to-improve-prediction-of-psychosis.aspx PsychCentral https://psychcentral.com/news/2018/01/23/speech-analysis-software-helps-predict- psychosis-in-those-at-risk/131601.html Laboratory Equipment https://www.laboratoryequipment.com/news/2018/01/speech-analysis-software- predicted-psychosis-risk-patients-83-percent-accuracy MobiHealth News http://www.mobihealthnews.com/content/mount-sinai-monetary-incentives-drive- medication-adherence

DOTMed: HealthCare Business Daily News – January 23 Dr. Helen S. Mayberg Helen S. Mayberg, MD, a neurologist renowned for her study of brain circuits in depression and for her pioneering deep brain stimulation research, which has been heralded as one of the first hypothesis-driven treatment strategies for a major mental illness, has joined the Mount Sinai Health System as the founding Director of The Center for Advanced Circuit Therapeutics. The new center will advance precision surgical treatments for neuropsychiatric disorders through the rapid conversion of neuroscience and neuroengineering innovations that correct brain circuit abnormalities to restore mood as well as motor and cognitive functioning. “Dr. Mayberg brings to Mount Sinai a research history distinguished by a translational and interdisciplinary focus that integrates imaging with clinical and surgical studies,” said Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience, Director of The Friedman Brain Institute, and Dean for Academic and Scientific Affairs at the Icahn School of Medicine at Mount Sinai. “Her research team will help Mount Sinai play a leading role globally in devising new and transformational treatments for depression and other neuropsychiatric disorders.” - Helen Mayberg, MD, Senior Faculty, Neurosurgery, Neurology, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, Director, The Center for Advanced Circuit Therapeutics, Mount Sinai Health System - Eric Nestler, MD, PhD, Dean, Academic and Scientific Affairs, Director, Friedman Brain Institute, Professor, Neuroscience, Pharmacological Sciences, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.dotmed.com/news/story/41063? utm_campaign=MagLink&utm_source=DMBusiness&utm_medium=print

Crain’s Health Pulse – January 23 Super Scope Mount Sinai Health System has received $1.2 million from the National Institutes of Health to help finance the purchase of a super-resolution microscope. Researchers across the health system will be able to use the device to observe viruses and small cellular structures that were previously too small to see. - Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180123/PULSE/180129977/state-is-cutting- hospitals-too-much-slack-on-financial-assistance

QNS News – January 22 Mount Sinai Queens In Astoria Receives $1 Million For Cardiac, Pediatric, and Radiology Units — Angela Matua Mount Sinai Queens has been working on a $150 million, six-story expansion and the community hospital recently received an influx of funding to add three new units. The new building is located right next to the original Mount Sinai Queens. It includes a state-of-the-art Emergency Department, six new operating room and expanded outpatient medical services. “Mount Sinai Queens continues to transform healthcare in our great borough,” said Caryn A. Schwab, executive director of Mount Sinai Queens. “The expansion of services in our new state-of-the-art Pavilion has allowed us to improve the quality and complexity of healthcare offered right here in Queens. The funding she’s helped secure is going to make a real difference in the lives of our residents,” she added. - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://qns.com/story/2018/01/22/mount-sinai-queens-astoria-receives-1-million-cardiac- pediatric-radiology-units/

CBC Radio – January 20 Hacking The Immune System To Fight Cocaine Addiction — Bob McDonald Anyone who’s ever been a habitual user of a drug like cocaine can tell you that once you start, it can be a slippery slope to addiction. A new study out in Nature Communications describes how scientists, led by Drew Kiraly, MD, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai, investigated how cocaine and the immune system conspire together to make the drug more addictive. They exposed mice to long-term cocaine and looked to see if cytokines, which are proteins in our immune system, went up or down in correlation with cocaine addiction. They narrowed it down to one protein, which Dr. Kiraly calls, “G-CSF,” otherwise known as granulocyte-colony stimulating factor. “It seems like there may be a bit of a vicious cycle to it where we’re taking this drug increases this protein, which increases the rewarding value of the drug,” said Dr. Kiraly. The hope is that eventually they can target this protein with an antibody in people to dial back the cravings. He’s currently working to see what effect this protein, G-CSF, might have opiate use in animals. - Drew Kiraly, MD, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.cbc.ca/radio/quirks/do-lobsters-feel-pain-fighting-cocaine-addiction-monkey- fight-club-for-peace-and-more-1.4489613/hacking-the-immune-system-to-fight-cocaine-addiction- 1.4489624

Kanka News – January 17 The United States And Europe Are Suffering From The Worst Flu In 13 Years – Stu Clark American disease control authorities said the country is suffering from the worst flu in 13 years, with 49 states reporting widespread outbreaks. The disease is also spreading in parts of Europe including the U.K. and Italy. In most hospital, emergency rooms are filled with patients, while the pharmacies are short of medicine. Adolfo Garcia-Sastre, PhD, director of the global health and emerging pathogens institute and professor of microbiology, medicine, and infectious diseases at the Icahn School of Medicine at Mount Sinai said, “We never know when the season will start, for how long it will last, and how many cases there will be, so it’s very difficult.” Doctors say the pathogens of the flu will continue to mutate, giving the disease a high mutation rate. As a result, people who have had the disease before still need to be vaccinated. - Adolfo Garcia-Sastre, PhD, Director, Global Health and Emerging Pathogens Institute, Professor, Microbiology, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://www.kankanews.com/a/2018-01-17/0018305799.shtml

The Huffington Post – January 23 Air Pollution Is Killing Millions Around The Globe Each Year — Erin Schumaker Air pollution isn’t among the causes of death that medical examiners list on death certificates, but the health conditions linked to air pollution exposure, such as lung cancer and emphysema, are often fatal. Air pollution was responsible for 6.1 million deaths and accounted for nearly 12 percent of the global death toll in 2016. “Air pollution is one of the great killers of our age,” wrote Philip Landrigan, MD, MSc, professor of environmental medicine and public health, and dean for global health at the Icahn School of Medicine at Mount Sinai, in a study published in the medical journal The Lancet. There are numerous studies linking air pollution to morbidity around the world. Air pollution is undoubtedly a global public health problem, but not all countries are equally affected. Because air pollution and related health problems can travel, no country can resolve its air pollution problem alone. This makes it crucial for local, national, and intergovernmental organizations to join forces to address air pollution. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.huffingtonpost.com/entry/air-pollution-is-killing-millions-around-the-globe- each-year_us_5a1ed396e4b017a311eb9c5f

Allergic Living – January 22 Which Test Is The Most Reliable To Know If A Child Has Really Outgrown A Food Allergy? — Scott Sicherer, MD Scott Sicherer, MD, professor of pediatrics, allergy and immunology, and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai said, “A blood test alone rarely provides enough diagnostic information. In terms of an evaluation into whether a particular food allergy has resolved, or for that matter any diagnosis of food allergy, the primary tools available to the allergist include: the medical history, skin tests, blood tests and medically supervised feeding, also called an oral food challenge.” Do not underestimate the importance of medical history, which includes symptoms such as hives after possible exposure to foods on your child’s avoidance list. Your doctor will use that information to select and interpret the tests. “I suggest at least a yearly evaluation for resolution and, when so many foods are avoided, consultation with a registered dietician to ensure adequate nutrition,” explained Dr. Sicherer. - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.allergicliving.com/experts/which-test-is-the-most-reliable-to-know-if-a-child- has-really-outgrown-a-food-allergy/

Reuters – January 22 ‘Misperceptions’ Keep Some From Agreeing To Donate Organs After Death — Carolyn Crist Although most Americans say they’re willing to be an organ donor after they die, some people never sign up because they’re unsure about what could happen to them in a medical emergency, according to a new study. In particular, survey respondents reported concerns about receiving adequate medical care if they registered to donate organs after they died. But transplant surgeons say health care teams caring for critically ill people are separate from the organ transplant teams. Sander Florman, MD, director of the Recanati/Miller Transplantation Institute and professor of surgery at the Icahn School of Medicine at Mount Sinai said, “The doctors taking care of the patient are not the same people involved with the transplant team or the organ procurement organization.” The transplant team “is only called in when patients meet the criteria for brain death or unrecoverable injuries,” Dr. Florman said. - Sander Florman, MD, Director, Recanati/Miller Transplantation Institute, Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-transplants-organ-donors/misperceptions-keep- some-from-agreeing-to-donate-organs-after-death-idUSKBN1FB2S9

WCBS New York – January 22 Doctors Talk Heart Health During GutwiZdom’s ‘Every Heart Matters’ Live Event — Deirdre Koppelman A medical emergency brought two Mount Sinai Health System’s top doctors together in a heartbeat. Jonathan A. Winston, MD, professor of medicine and nephrology at the Icahn School of Medicine at Mount Sinai developed heart disease. The diagnosis came very suddenly and Dr. Winston needed major surgery. “I’m known to have high blood pressure, but was never proactive about heart health,” said Dr. Winston. “I was going to have my knees replaced, so I had a routine heart testing pre-op, and I failed my stress test, which is when I found out I had heart disease,” Dr. Winston explained. They referred him to John D. Puskas, MD, site chair of cardiovascular surgery at Mount Sinai St. Luke’s, Mount Sinai West, and Mount Sinai Beth Israel and director of surgical coronary revascularization for the Mount Sinai Health System. Dr. Puskas is a leader in the field that does minimally invasive coronary revascularization. Dr. Winston got the benefits of an open heart surgery with a minimally invasive approach. “Knowing your numbers is one of the themes of the American Heart Association,” said Dr. Puskas. - Jonathan A. Winston, MD, Professor, Medicine, Nephrology, Icahn School of Medicine at Mount Sinai - John D. Puskas, MD, Site Chair, Cardiovascular Surgery, Mount Sinai St. Luke’s, Mount Sinai West, Mount Sinai Beth Israel, Professor, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, Director, Surgical Coronary Revascularization, Mount Sinai Health System Learn more: http://newyork.cbslocal.com/2018/01/22/gutwizdom-every-heart-matters/

MedPage Today – January 22 Antithyroid Tx During Pregnancy May Be Risky For Baby — Kristen Monaco The risk of congenital malformations may be substantially higher for babies exposed to antithyroid medications in utero, a new study found. Pregnant women with Graves' disease medicated during the first trimester showed a higher prevalence of babies born with either overall or organ-specific congenital malformations versus mothers not on the medication. Asked for his perspective, Terry F. Davies, MD, professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai and co-director of the Thyroid Center at Mount Sinai Union Square, said: “This is an area of great concern to women and physicians and has been a highly contentious area of discussion. Importantly, the data suggests that switching to PTU when a woman becomes pregnant does not reduce the malformation rate compared to women who proceed with methimazole.” He added that the problem remains that the physician does not see a pregnant patient early enough to influence the potential damage to organogenesis with methimazole. "There is also no data available concerning the seriousness of the hyperthyroidism, although there is a suggestion that the higher the dose of the drugs, the more likely a malformation was to appear,” Dr. Davies added. - Terry F. Davies, MD, Professor, Medicine, Endocrinology, Diabetes and Bones Disease, Icahn School of Medicine at Mount Sinai, Co-Director, The Thyroid Center, Mount Sinai Union Square Learn more: https://www.medpagetoday.com/endocrinology/thyroid/70667

Wired – January 23 Meet The Amateur Scientist Who Discovered Climate Change — Charles C. Mann Eighty years ago, Guy Callendar built the first climate change model to predict the effects of greenhouse gases. Now his successors are plotting ways to reengineer the air. Geoengineering is not a new idea. Ancient religions promised for millennia to control the weather by negotiating with heavenly powers. Legitimate experiments in “cloud seeding” – sprinkling tiny crystals of dry ice in clouds to stimulate raindrop formation – began in the 1940s. Then came proposals to offset climate change from carbon monoxide, the first in 2006, from the Nobel Prize-winning chemist Paul Crutzen. Could natural systems be harnessed to suck carbon from the air? Why not create a new Carboniferous by covering the two biggest deserts in the world – the Sahara and the Australian outback – with trees? In 2009, three researchers – two at the NASA Goddard Institute for Space Studies, one at the Icahn School of Medicine at Mount Sinai – proposed just that. At bottom, the idea is easy to understand. Very roughly speaking, humankind emits 40 billion tons of carbon dioxide a year, mostly by burning fossil fuels. About 40 percent of the total is absorbed by plants, microorganisms, and the ocean. What to do, in a world brimming with fossil fuels? In climate change, all choices involve leaps into the unknown. The important thing is that they have choices, and we are still at the stage where, however dimly, we can see them working. - Icahn School of Medicine at Mount Sinai Learn more: https://www.wired.com/story/meet-the-amateur-scientist-who-discovered-climate-change/

Reader’s Digest – January 21 Seven Eczema Treatments Dermatologists Use On Themselves — Denise Mann, MS More than 30 million Americans, including babies and children, live with eczema, and many are driven to distraction by the intense itching and inflammation. If someone is flaring, Emma Guttman-Yassky, MD, PhD, professor of dermatology, clinical immunology, medicine, vice chair of research in the department of dermatology and director of the center for excellence in eczema in the laboratory of inflammatory skin diseases at the Icahn School of Medicine at Mount Sinai, will start with a strong topical steroid used twice daily for one week, and then switch to a moderate strength for four weeks, twice daily before decreasing it gradually to about once or twice a week. Another topical crisaborole (Eucrisa) blocks PDE4 enzymes within the skin that have been linked to inflammation. Protopic and Elidel carry black box warnings, citing a possible increased risk for cancer. A black box is the strongest admonishment that the U.S. Food and Drug Administration can offer. “Eucrisa doesn’t have black box,” Dr. Guttman-Yassky said. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/eczema-treatments/

Women’s Health – January 22 We Asked Eight Derms What They Use To Fight Wrinkles, They All Said The Same Thing — Jessie Van Amburg When we recently asked a group of top dermatologists how they treat and prevent wrinkles on their own faces, we were floored to get the same answer from all eight of them: retinoids. “Retinol is the single best- studied ingredient in fighting skin aging,” explained Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetics and clinical research in dermatology at The Mount Sinai Hospital. Retinoids, the broad term for derivative of vitamin A that included OTC retinol and adapalene, stimulates collagen production and minimizes the appearance of fine lines and wrinkles, he said. Dr. Zeichner is not alone in his praise for retinoids. Several of the dermatologists that we talked to specifically said that Retin-A was their retinoid of choice. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.womenshealthmag.com/beauty/retinol-to-prevent-wrinkles

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 24, 2018 Date: Wednesday, January 24, 2018 2:08:17 PM Attachments: ATT00001.txt

In the News January 24, 2018

Newsday – January 24 South Nassau Communities Hospital Officially Partners With Mount Sinai— Delthia Ricks South Nassau Communities Hospital officially became the Long Island flagship health care institution in the Mount Sinai Health System after a unanimous vote by the Oceanside hospital’s board of trustees. Mount Sinai Health System trustees approved the agreement last month. No decision has yet been made on how Mount Sinai’s name will be incorporated into that of South Nassau. “We are thrilled about what this means for patients and families on Long Island and look forward to working closely with our Long Island partners to continue advancing care in the region,” said Kenneth L. Davis, MD, president and CEO for the Mount Sinai Health System. South Nassau, a 455-bed hospital that has served Long Island’s South Shore since 1928, is expected to expand its facilities under the agreement, with a $120 million capital contribution from Mount Sinai. The cash will aid South Nassau’s five-year master facility plan, which expands the hospital’s surgical facilities, intensive care units, and emergency department. “Long Island has been a target for us for several reasons,” said Arthur Klein, MD, president of the Mount Sinai Health Network. “We have a growing physician presence in Hewlett, Nesconset, Huntington, Bay Shore, and Manhasset. What we had been lacking was a true institutional partner. Being landlocked here in Manhattan, we thought it was important to grow and expand our reach. So when South Nassau put out a request for partnership proposal, we responded very enthusiastically.” - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - Arthur Klein, MD, President, Mount Sinai Health Network Learn more: https://www.newsday.com/news/health/south-nassau-communities-hospital-mount-sinai-1.16318208 Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180124/PULSE/180129964/nyc-files-500m-lawsuit-against-opioid-makers Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/01/24/cuomo-insures- daca-026972 HealthLeaders Media http://www.healthleadersmedia.com/leadership/mount-sinai-health-acquires-south-nassau-hospital# Innovate Long Island http://www.innovateli.com/south-nassau-mount-sinai-make-almost-official/

Politico New York – January 24 A New Microscope — Dan Goldberg Mount Sinai purchased a $1.2 million microscope with money it received from the National Institutes of Health. This microscope, a Leica TCS SP8 STED 3X, can show structures as small as viruses. - Mount Sinai Health System Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/01/24/cuomo-insures-daca- 026972

M.D. Alert – January 23 Transitional Care Nurses In The ED May Help Curb Geriatric Hospitalizations — Marilynn Larkin Evaluation by a transitional care nurse (TCN) in the emergency department (ED) may reduce the risk of inpatient admission for patients 65 or older, according to a study conducted at the Icahn School of Medicine at Mount Sinai. “Both hospitalization and being discharged from the ED carry significant risks for older adults, including iatrogenic complications, functional and cognitive decline, and loss of independence,” said lead researcher Ula Hwang, MD, associate professor of emergency medicine, geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. She added the study highlights the importance of greater care to support transitions from the ED. “The next research steps are to better understand what the TCN nurses did at each site and understand the degree to which they provided and facilitated care transitions for individual participants,” said Dr. Hwang. - Ula Hwang, MD, Associate Professor, Emergency Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/transitional-care-nurses-in-the-ed-may-help-curb-geriatric-hospitalizations

Digital Journal – January 23 Speech Analysis Software Predicts Psychosis— Tim Sandle A new study shows how speech analysis software can predict a mental illness like psychosis, in at-risk patients, with up to 83 percent accuracy. This offers a potential diagnostic tool for psychiatry. The research came from the Icahn School of Medicine at Mount Sinai, and it signals how big-data approaches have potential to improve prediction of psychiatric and other medical disorders. This was assessed via computer-based analysis of speech transcripts, which were obtained from interviews with at-risk youths. According to lead researcher, Cheryl Corcoran, MD, senior faculty of psychiatry and program leader of psychosis risk at the Icahn School of Medicine at Mount Sinai, “The results of this study are exciting because this technology has the potential to improve pre-diction of psychosis and ultimately help us prevent psychosis by helping researchers develop re-mediation and training strategies that target the cognitive deficits that may underlie language disturbance.” The findings could lead to the development of novel computerized methods to characterize and predict earlier complex behaviors, like psychosis. - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: http://www.digitaljournal.com/tech-and-science/science/speech-analysis-software-predicts-psychosis/article/512923 Additional coverage: Psych News Alert http://alert.psychnews.org/2018/01/speech-analysis-program-may-improve.html New Atlas https://newatlas.com/speech-analysis-predict-psychosis-ibm/53105/

MD Magazine – January 24 Genetic Mutation Slows Parkinson Disease Progression — Carisa D. Brewster Parkinson disease (PD) patients with a mutation of the leucine-rich repeat kinase 2 (LRRK2) gene show a slower decline in motor functioning compared to patients without the mutation, according to a new study. Major mutations in the LRRK2 gene are the greatest contributor to the development of PD and are present in one to two percent of the people with PD worldwide, said study author Rachel Saunders-Pullman, MD, associate professor of neurology at the Icahn School of Medicine at Mount Sinai. For certain groups, such as Ashkenazi Jews and North African Arab-Berbers, the gene is present in about 15 percent of those with PD. “This study supports that with the G2019S mutation of LRRK2, the motor progression is slightly slower than other Parkinson’s as a whole,” Dr. Sanders-Pullman said. - Rachel Saunders-Pullman, MD, Associate Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdmag.com/medical-news/genetic-mutation-slows-parkinson-disease-progression

Sleep Review Magazine – January 23 Bright Light Therapy Improves Sleep In People Treated For Cancer Results of a randomized controlled trial suggest that systematic bright light exposure can improve sleep for fatigued people who have been treated for cancer. The pilot study results show that mean sleep efficiency, the percentage of time in bed when the person is sleeping, improved to clinically normal levels in the bright light therapy group. “In a pilot study, a systematic light exposure intervention with a mixed group of fatigued cancer survivors was significantly more effective than comparison dim light exposure in improving sleep efficiency,” says lead author Lisa M. Wu, PhD, adjunct assistant professor of population health science and policy at the Icahn School of Medicine at Mount Sinai. The research team, led by principal investigator William H. Redd, PhD, professor of oncological sciences at the Icahn School of Medicine at Mount Sinai, studied 44 people who had completed treatment for cancer and met criteria for clinically significant fatigue at screening. Participants were randomized to either a bright white light intervention or a comparison dim light condition. They were provided a light box and instructed to use it every morning for 30 minutes for four weeks. - William H. Redd, PhD, Professor, Oncological Sciences, Icahn School of Medicine at Mount Sinai - Lisa M. Wu, PhD, Adjunct Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: http://www.sleepreviewmag.com/2018/01/bright-light-therapy-improves-sleep-people-treated-cancer/

Healthcare IT News – January 23 Mount Sinai Boosts Medication Adherence Through App That Pays Patients To Take Pills — Jonah Comstock Mount Sinai Health System is trying a new way to get high-risk patients to take their medications: financial incentives. Supported by a grant from Health 2.0 and the New York City Economic Development Corporation, the New York health system has enrolled 12 patients in a pilot with startup Wellth. “What Wellth did is they said ‘Here’s a really big problem we want to solve’ and they did a ton of research and they were really utilizing research that’s been done in behavioral economics,” said Jill Carroll, an IT project manager at the Mount Sinai Health System. With Wellth’s technology, patients can earn a few dollars for taking their pills on time, which can add up to a significant amount over a few months. At Mount Sinai, for example, patients can earn $50 for one month of adherence. To report their adherence, they simply snap a photo with their phone’s camera of the pills in hand. - Jill Carroll, IT Project Manager, Mount Sinai Health System Learn more: http://www.healthcareitnews.com/news/mount-sinai-boosts-medication-adherence-through-app-pays-patients-take-pills

MD Magazine – January 24 Crohn’s Disease: Key Hopes And Understandings Bruce Sands, MD, MS, Burill B. Crohn professor of medicine and chief of the Dr. Henry D. Janowitza division of gastroenterology at the Icahn School of Medicine at Mount Sinai said, “My hope for the future is that we’re going to be able to identify the right drug for the right patient at the right time and having more options for treatment will eventually allow us to do that. Predictive biomarkers will allow us to choose the right drug for the right patient.” He added that “the availability of therapeutic drug monitoring, particularly for biologic therapies, will help fine tune treatment.” The year 2032 will be the 100th anniversary of the discovery of Crohn’s disease. “The field is very exciting, and there a lot of parallel things happening,” said Marla Dubinsky, MD, professor of pediatrics and gastroenterology at the Icahn School of Medicine at Mount Sinai. “I think we should work on ultimate strategies that get [patients] in such deep remission that we can maybe use our microbial-based therapies to keep them there. That’s the exciting part of what the next 15 years will look like.” - Bruce E. Sands, MD, MS, Burrill B. Crohn Professor of Medicine, Gastroenterology, Chief, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai - Marla C. Dubinsky, MD, Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdmag.com/insights/crohns-disease/crohns-disease-key-hopes-and-understandings

TLC – January 23 I Am Jazz: Big Trouble In The Big Apple Although born male, Jazz Jennings is a transgender female and has been living as a girl since kindergarten. Her parents have spent years finding doctors to treat their daughter, while fighting the discrimination and misconceptions associated with what it means to be transgender. Now at 17 years old, Jazz has learned she needs to lose 30 pounds to be eligible for bottom surgery. She commits to losing weight and heads to New York City for a consultation with Jess Ting, MD, surgical director at Mount Sinai’s Center for Transgender Medicine and Surgery and assistant professor of plastic and reconstructive surgery at the Icahn School of Medicine at Mount Sinai. Jazz was referred to Dr. Ting by Marci Bowers, MD, a pelvic and gynecologic surgeon at Mount Sinai’s Center for Transgender Medicine and Surgery. Dr. Ting explained to Jazz that he has concerns with her having this operation because she is younger than anyone he’s operated on at the Center. “This is a big step and you want to make sure the patient is prepared, understands what they’re doing and is making the right decision for themselves,” said Dr. Ting. Dr. Ting recommended inserting a tissue expander in order to stretch the skin to prepare for bottom surgery. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai - Marci Bowers, Professional Lecturer, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Pelvic and Gynecologic Surgeon, Mount Sinai’s Center for Transgender Medicine and Surgery Learn more: https://www.tlc.com/tv-shows/i-am-jazz/full-episodes/big-trouble-in-the-big-apple

ABC News – January 23 How To Clean Your House To Help Keep Your Family Safe From The Flu — Gio Benitez As the flu season worsens, people are looking within their homes to see what they can do to prevent the flu. A house can be a surprising hotbed of germs, and it’s difficult to contain the virus because of how quickly it spreads. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital, advises people to forget what their parents and teachers taught them about sharing during flu season. “During flu season, it’s more hygienic to have people dry their hands on paper towels, rather than everyone in the family drying on one hand towel.” - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://abcnews.go.com/Health/clean-house-family-safe-flu/story?id=52522135

HealthDay – January 23 Essure Female Sterilization Device Appears Safe — Dennis Thompson Essure implants used in female sterilization have come under fire in recent years, with women reporting a wide array of problems to the U.S. Food and Drug Administration. However, a new study from France shows the implants are relatively safe and do not raise the risk of side effects or health problems. Essure implants – small spring-like coils – are inserted into the fallopian tubes through the vagina, eliminating the need for any incisions. The procedure can be performed in an office setting in less than 15 minutes. Essure is a valuable option for women with health problems serious enough that they might die under general anesthesia, which is required for laparoscopic surgery, said Charles J. Ascher-Walsh, MD, associate professor of obstetrics, gynecology and reproductive science and director of the fellowship in urogynecology, female pelvic medicine, and reconstructive surgery at the Icahn School of Medicine at Mount Sinai. Dr. Ascher-Walsh doubts that the findings will end suspicion regarding Essure’s safety. “This will give a little bit more evidence to us when we’re trying to let a patient know it’s not as bad as it sounds, but it is one chord in a long tune of negativity,” he said. “I honestly don’t think it’s going to change too much.” - Charles J. Ascher-Walsh, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, Director, Fellowship in Urogynecology , Female Pelvic Medicine, and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/women-s-health-information-34/birth-control-news-62/essure-female-sterilization-device- appears-safe-study-730435.html Additional coverage: The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay730435_20180123_Essure_Female_Sterilization_Device_Appears_Safe__Study.html Medical Xpress https://medicalxpress.com/news/2018-01-essure-female-sterilization-device-safe.html

Shape Magazine – January 24 Can You Get The Flu Twice In One Season? — Cassie Shortsleeve For the first time in 13 years, there’s widespread flu activity in every single state in the continental U.S., according to the Centers for Disease Control and Prevention, and, sadly, even healthy people have died from the flu this winter. So, needless to say, you’re likely in one of three camps when it comes to the flu: thankful for getting the vaccine; wishing you had; or, if you’ve already fallen victim to the virus, you might be wondering: can I get the flu again this winter? The short answer is yes, said Nicole M. Bouvier, MD, associate professor of medicine, infectious diseases, and microbiology at the Icahn School of Medicine at Mount Sinai. “There are four different strains of the flu that could be circulating at any given time,” she explained. Currently, the main strain in the U.S. is influenza A (H3N2). Experts have also seen cases of influenza B, but not nearly as many. And if you’ve suffered from one strain, you’re still susceptible to infection from another, said Dr. Bouvier. That’s because the different strains are different viruses, and they’re not neutralized by the same antibodies. For now, your best bet is to get the flu shot. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.shape.com/lifestyle/mind-and-body/can-you-get-flu-twice-one-season

Medscape – January 23 Art Class Improves Medical Students’ Observation Skills — Mary Beth Nierengarten Interest in integrating the arts and humanities into medical education is not new. Several programs around the country offer or require medical students to take classes in the arts or humanities to help foster skills that are essential to good clinical care, including observation, critical thinking, and empathy. However, few studies have formally assessed the effect of such training on specific clinical skills. Now, a randomized controlled study published in Ophthalmology does just that. Researchers found a significant improvement in observational skills among students who underwent observation training in art compared with students who did not. "The paper is important because it demonstrates that a structured program in art observation improved first year medical students' observational skills on clinical images," said Barry S. Coller, MD, clinical professor of medicine at the Icahn School of Medicine at Mount Sinai. Dr. Coller teaches the Pulse of Art course at the Icahn School of Medicine at Mount Sinai, which is designed to improve observational skills through the study of art and history of medicine. - Barry S. Coller, MD, Clinical Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/891696

Self Magazine – January 23 Eleven Things You Should Know About The Birth Control Patch — Korin Miller Thanks to the wonders of modern medicine, you’ve got a plethora of options when it comes to birth control. But there’s one birth control method experts say women aren’t usually familiar with but might want to consider. The patch is a thin, plastic square that’s about 1.5 inches across. It kind of looks like a Band-Aid, and you stick one side of it to your skin. The side effects of the patch are pretty much the same as those of the pill and vaginal ring. These symptoms are “usually transient and happen the first few months... as your body adjusts,” said Suzanne S. Fenske, MD, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. “Most women do not feel that this is significant enough to warrant stopping the patch.” If you start the patch, symptoms persist for many months, and they’re bothersome enough to interfere with you quality of life, talk to your doctor. - Suzanne S. Fenske, MD, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/birth-control-patch-facts

Self Magazine – January 18 Here’s Why Amber Rose Got A Breast Reduction — Carolyn L. Todd Amber Rose, the former Dancing with the Stars contestant, recently underwent breast reduction surgery and kept fans aware of the news by posting on social media. She is not the first celebrity to open up about the procedure. Between 1997 and 2013, there was a 157 percent increase in breast reduction surgeries in the U.S., according to The American Society For Aesthetic Plastic Surgery. People may opt for breast reduction surgery for functional reasons, cosmetic reasons, or both. “Many women have what we call macromastia,” said Peter Taub, professor of surgery and medical education at the Icahn School of Medicine at Mount Sinai. “Pendulous breasts can transmit [weight] to the back, shoulders, and neck,” said Dr. Taub, which can cause serious pain and discomfort on a daily basis. - Peter Taub, MD, Professor, Surgery, Pediatrics, Neurosurgery, Medical Education, Dentistry, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/heres-why-amber-rose-got-a-breast-reduction

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 25, 2018 Date: Thursday, January 25, 2018 1:03:26 PM Attachments: ATT00001.txt

In the News January 25, 2018

Becker’s Hospital Review – January 24 Mount Sinai Health System To Affiliate With South Nassau Communities Hospital: Four Things To Know — Alyssa Rege The boards of trustees of Mount Sinai Health System and South Nassau Communities Hospital announced their intent to affiliate today. If approved, South Nassau Communities Hospital will become Mount Sinai’s flagship hospital in Long Island, New York. South Nassau Communities Hospital’s current board of directors will maintain governance over daily operations at the 455-bed hospital. Two representatives from Mount Sinai’s and South Nassau’s boards will also join the other institution’s board. As part of the deal, Mount Sinai will infuse $120 million in capital contributions to South Nassau Communities Hospital to expand its surgical facilities, intensive care unties, and emergency department as part of the hospital’s five-year expansion plan. The transaction is pending regulatory approval, which officials expect to obtain within the coming months. - Mount Sinai Health System Learn more: https://www.beckershospitalreview.com/hospital-transactions-and-valuation/mount-sinai- health-system-to-affiliate-with-south-nassau-communities-hospital-4-things-to-know.html Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180125/PULSE/180129949/cuomo-releases- details-of-700m-plan-for-new-brooklyn-health-system LI Herald http://www.liherald.com/stories/snch-announces-partnership-with-mount-sinai,99494 Long Beach Patch https://patch.com/new-york/longbeach/south-nassau-joins-mount-sinai-hospital- network Long Island Business News http://libn.com/2018/01/24/south-nassau-joining-mt-sinai/ Rockville Centre Patch https://patch.com/new-york/rockvillecentre/south-nassau-joins-mount-sinai- hospital-network?utm_source=article- mostrecent&utm_medium=rss&utm_term=business&utm_campaign=recirc&utm_content=normal DOT Med Healthcare Business Daily News https://www.dotmed.com/news/story/41275 MedicalHealthNews.net http://www.medicalhealthnews.net/snch-announces-partnership-with-bmount- sinaib

Western Queens Gazette – January 24 One Million Dollar Investment For Mount Sinai Queens New York State Assembly Member Aravella Simotas announced that Mount Sinai Queens received one million in capital funding for three separate projects that she nominated for support from the New York State Assembly. “Mount Sinai Queens continues to transform healthcare in our great borough. The expansion of services in our new state-of-the-art Pavilion has allowed us to improve the quality and complexity of healthcare offered right here in Queens. We couldn’t do this without great partners like Assembly Member Aravella Simotas. The funding she’s helped secure is going to make a real difference in the lives of our residents. We are incredibly grateful for her efforts and support,” said Caryn A. Schwab, executive director of Mount Sinai Queens. - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://www.qgazette.com/news/2018-01- 24/Features/1M_Investment_For_Mount_Sinai_Queens.html Additional coverage: Queens Tribune http://queenstribune.com/simotas-secures-1m-mount-sinai-queens/ NY 1 News http://www.ny1.com/nyc/queens/news/2018/01/25/hospital-gets-financial-boost-to-add-new- services

Medscape – January 24 Transitional Care Nurses In The ED May Help Curb Geriatric Hospitalizations — Marilynn Larkin Evaluation by a transitional care nurse (TCN) in the emergency department (ED) may reduce the risk of inpatient admission for patients 65 or older, according to a study conducted at the Icahn School of Medicine at Mount Sinai. “Both hospitalization and being discharged from the ED carry significant risks for older adults, including iatrogenic complications, functional and cognitive decline, and loss of independence,” said lead researcher Ula Hwang, MD, associate professor of emergency medicine, geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. She added the study highlights the importance of greater care to support transitions from the ED. “The next research steps are to better understand what the TCN nurses did at each site and understand the degree to which they provided and facilitated care transitions for individual participants,” said Dr. Hwang. - Ula Hwang, MD, Associate Professor, Emergency Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/891662

Times Live – January 25 Artificial Intelligence Predicts Psychosis — Tanya Farber A computer has now been able to predict psychotic behavior in human beings just by analyzing their speech patterns. The artificial intelligence breakthrough has come about at the Icahn School of Medicine at Mount Sinai. Psychosis is a symptom, not an illness, but could be brought on by a mental or physical illness, substance abuse, or extreme stress or trauma. In the study, the computer was in effect able to pick up the disturbance in the flow of meaning when speaking – other words, going off track as a predictor for who would later develop psychosis. Lead researcher, Cheryl Corcoran, MD, senior faculty of psychiatry and program leader of psychosis risk at the Icahn School of Medicine at Mount Sinai said, “The results are exciting because this technology has the potential to improve prediction of psychosis and ultimately help us to prevent it.” It could do this by “helping researchers develop re-mediation and training strategies that target the cognitive deficits that underlie language disturbance,” she added. She hopes that the technology could be “applied across psychiatry and plausibly in other fields of medicine too.” - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: https://www.timeslive.co.za/sunday-times/lifestyle/health-and-sex/2018-01-25-artificial- intelligence-predicts-psychosis/

Palm Beach Florida Weekly – January 25 Getting To The Heart Of The Matter — Gonzalo Loveday, MD Cardiovascular disease is the leading killer of both men and women in the United States. With the start of February — American Heart Month — just days away, this is the perfect time to take stock of your cardiovascular health, make sure you’re doing all you can to prevent heart disease, and become familiar with the options available to you, should you need medical intervention. Jupiter Medical Center is working with Mount Sinai Heart New York — one of the premier cardiovascular centers in the county — to transform cardiovascular care in our community. As a result of our strategic partnership, Mount Sinai Heart New York at Jupiter Medical Center enables cardiologists here in South Florida and those based in New York to collaborate in providing world-class care to patients in our community. This partnership guides nearly all facets of our cardiac care, including interventional cardiology, cardiac rehabilitation, noninvasive imaging, congestive heart failure, wellness and prevention, research and education. In addition, patients and families benefit from research and practices pioneered at Mount Sinai New York. - Gonzalo J. Loveday, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Chief Medical Director, Mount Sinai Heart New York at Jupiter Medical Center Learn more: https://palmbeach.floridaweekly.com/articles/getting-to-the-heart-of-the-matter/

KUNC News – January 24 Some States Establish Pesticide Buffer Zone, But None Where Much Is Sprayed: The Midwest— Anna Casey Hundreds of rural schools in the Midwest states nestle against fields of corn and soybeans that are routinely sprayed with pesticides that could drift onto school grounds. Health experts say those pesticides might pose risks to children, and nine states in other regions of the country have been concerned enough to pass laws requiring buffer zones. But states in the Midwest do not require any kind of buffer zone between schools and crop fields and seldom require any notification that pesticides are about to be sprayed. Philip Landrigan, MD, MSc, professor of environmental medicine and public health and dean for global health at the Icahn School of Medicine at Mount Sinai, said the industry exerts too powerful of an influence when it comes to regulations on chlorpyrifos and other pesticides. “I worked many years ago studying lead toxicity,” Dr. Landrigan said, who has spent decades researching environmental pediatrics and exposure to toxic chemicals, “We saw a very similar pattern there. The lead industry failed to find any toxicity of lead to children, but studies down through non-industry funding did find hazards.” - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: http://www.kunc.org/post/some-states-establish-pesticide-buffer-zones-none-where-much- sprayed-midwest

The Atlantic – January 24 I Got Hypnotized Over Skype And It Actually Worked — Katie Heaney Brain scans of hypnosis patients show reduced anxiety in the anterior cingulate cortex, the part of the brain that decides what to worry about. Hypnosis turns down this part of the brain, so that patients can focus on what they want to focus on. Hypnosis isn’t just good for anxiety, either. Alison Snow, PhD, assistant director of cancer supportive services for Mount Sinai Downtown, employs hypnosis as a tool to ease the suffering of cancer patients – partly their anxiety, but also their pain. Currently she and a colleague are studying its effects on patients with neck cancer, who were randomly assigned to receive either hypnosis or more traditional therapy. They haven’t finished collecting data yet, but Dr. Snow said the existing research supports their efforts, as do her patients. “I had one patient who was a hypnotherapist herself,” said Dr. Snow. When the patient was randomized not to receive hypnosis, she quit the study, and asked to get hypnosis anyway. Dr. Snow finds hypnosis especially useful for cancer patients who want to treat their pain and anxiety, but don’t want to take more medications. “The patients I work with obviously have a reason to be anxious, and so we normalize that, and understand that, and we try to teach them skills like self-hypnosis to manage their anxiety.” Her patients are given a CD with guided hypnosis, and sometimes record their sessions so they can listen back and practice on themselves. - Alison Snow, PhD, Assistant Director, Cancer Supportive Services, Mount Sinai Downtown Learn more: https://www.theatlantic.com/technology/archive/2018/01/i-got-hypnotized-over-skype-and- it-actually-worked/551351/

Daily Mail – January 24 Contraceptive Essure Is Safe — Stephen Matthews A contraceptive implant that has driven scores of women to the brink of suicide could be safe after all, a major study suggests. Essure, a controversial sterilization device, has come under fire in recent years amid claims the form of permanent birth control leads to crippling pain. Researchers found women who got the Essure implant faced a 0.13 per cent risk of immediate complications - six times less than surgery. The French government analysis, published in JAMA, comes just months after Essure was withdrawn from sale across the world - apart from in the United States. Charles J. Ascher-Walsh, MD, associate professor of obstetrics, gynecology and reproductive science, and the director of the fellowship in urogynecology, female pelvic medicine and reconstructive surgery at the Icahn School of Medicine at Mount Sinai, warned the results “won’t change much.” He added, “this will give a little bit more evidence to us when we’re trying to let a patient know it’s not as bad as it sounds, but it’s one chord in a long tune of negativity,” he said. - Charles J. Ascher-Walsh, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, Director, Fellowship in Urogynecology, Female Pelvic Medicine, and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.dailymail.co.uk/health/article-5307471/Contraceptive-implant-safe-all.html Additional coverage: MedicalHealthNews.net http://www.medicalhealthnews.net/a-contraceptive-implant-that-has-driven- scores-of-women-to-the-brink-of-suicide-could-be-safe-after

Elite Daily – January 24 Seven Fast Sunburn Cures For Spring Break That Skincare Experts Swear By — Julia Guerra Spring break can feel so far away when you proactively live in an oversized coat and snow boots every day, but isn’t that even more of an incentive to start planning your warm weather vacation now? Fast sunburn cures should be on your radar if you are making the transition from snow to sand for a week, otherwise your skin will be paying a very painful price. While taking a cold shower will certainly cool down an overheated body, Heidi Waldorf, MD, associate clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of laser and cosmetic dermatology at the Mount Sinai Hospital, has a better idea. “Use cold compresses with a hand towel or gauze soaked in a mixture of equal parts water and milk for ten to 20 minutes at a time, a few times a day,” she said. “The lactic acid and fat in the milk will soothe the skin. If you’re not allergic to it and you have an aloe plant, you can cut it and apply the fresh aloe, which is anti-inflammatory.” - Heidi Waldorf, MD, Associate Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Laser and Cosmetic Dermatology, Mount Sinai Hospital Learn more: https://www.elitedaily.com/p/7-fast-sunburn-cures-for-spring-break-that-skincare-experts- swear-by-8006143

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 26, 2018 Date: Friday, January 26, 2018 11:21:16 AM Attachments: ATT00001.txt

In the News January 26, 2018

Crain’s Health Pulse – January 25 Now Open Mount Sinai Health System opened an urgent-care center in Brooklyn's Dumbo neighborhood at 110 York Street that will offer extended night and weekend hours. - Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180126/PULSE/180129935/phoenix-house-to-sell- drug-treatment-center-property-in-trendy-dumbo Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/26/goldens-opioid-comments-come-under-fire-027729 News Medical & Life Sciences https://www.news-medical.net/news/20180125/Mount-Sinai-Health- System-announces-opening-of-new-full-service-urgent-care-center-in-Dumbo.aspx

MedPage Today – January 25 Stent Retrievers And Aspiration On Par For Initial Thrombectomy Strategy — Crystal Phend Which mechanical thrombectomy tool clinicians reach for first in large vessel ischemic strokes may not make much difference in outcomes, the COMPASS trial showed. Aspiration as the initial strategy was noninferior to initial stent retriever use for good functional outcomes at 90 days. Nor was there any differential shift in the overall Rankin scores, J Mocco, MD, professor of neurosurgery at the Icahn School of Medicine at Mount Sinai, director of cerebrovascular center at The Mount Sinai Hospital and vice chair of neurosurgery for the Mount Sinai Health System, and colleagues reported at the International Stroke Conference. "Now we have level I evidence that stent retrievers and primary aspiration have equivalent clinical outcomes in large vessel occlusion," Dr. Mocco concluded at a press briefing for the late-breaking clinical trial session. Dr. Mocco cautioned that the data should be considered preliminary, as small changes may be made if one patient must be excluded due to consent problems that were just discovered and are under investigation by the group. - J Mocco, MD, Professor, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, The Cerebrovascular Center, Mount Sinai Hospital, Vice Chair, Neurosurgery, The Mount Sinai Health System Learn more: https://www.medpagetoday.com/meetingcoverage/isc/70755 Additional coverage: MedicalXpress https://medicalxpress.com/news/2018-01-aspiration-good-stent-large-vessel-clots.html Digital Journal http://www.digitaljournal.com/pr/3635879 Healio https://www.healio.com/cardiac-vascular- intervention/cerebrovascular/news/online/%7B1f5120b4-2a3a-4ad5-a17a-0c76c22cb86d%7D/first-line- aspiration-noninferior-to-stent-retriever-for-acute-ischemic-stroke Medical Research https://medicalresearch.com/stroke/aspiration-therapy-offers-alternative-to-stent- retrievers-for-large-vessel-stroke/39616/ Pharmacy Choice https://www.pharmacychoice.com/news/article.cfm?Article_ID=1932808

MedPage Today – January 25 Testing, Rigorous Research Needed For Cognition In MS — Judy George A team of international researchers and clinicians is calling for changes in how cognitive dysfunction in multiple sclerosis (MS) is studied. "Patients have known that cognitive decline is a problem for a really long time, but only in the last 25 years have researchers started to pay more attention to it," said James Sumowski, PhD, associate professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai, the corresponding author of a statement about cognition and MS published in Neurology. In the last ten years, clinical interest in cognition in MS has grown exponentially, he noted, with pharmaceutical companies now looking at cognitive outcomes in MS trials. “This is a good time to figure out the important questions that are holding the field back,” said Dr. Sumowski. In their paper, Dr. Sumowski's team looked at three major areas: measuring cognitive changes, neuroimaging, and treating cognitive decline. "We need to believe patients. When they say they have a cognitive problem, they're not telling you where they fall in the normal distribution of a test. They're telling you they have a decline from where they were earlier, from previous function." Dr. Sumowski and co-authors also proposed more prospective neuroimaging studies to create algorithms for risk of cognitive decline and more rigorous work in the nascent field of cognitive rehabilitation. - James F. Sumowski, PhD, Associate Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/neurology/multiplesclerosis/70756

Healthline – January 25 Can An Algorithm Predict Schizophrenia? — Gillian Mohney A small study out this week found that a computer algorithm could identify who would develop psychosis with an accuracy of up to 83 percent. Researchers from the Icahn School of Mount Sinai and other institutions used a computer algorithm to examine the speech patterns of 93 at-risk young people in New York and California. Words were coded so that the algorithm could determine which words were out of place. As a result, the program could figure out when a person likely went off topic during the interview. Cheryl Corcoran, MD, senior faculty of psychiatry and program leader of psychosis risk at the Icahn School of Medicine at Mount Sinai, and co-author of the study, said that is people were prone to losing the thread of the conversation they appeared to be more at risk to develop psychosis. Dr. Corcoran hopes this kind of research will eventually be turned into a screening tool. “My hope is that we can use this to screen individuals and if it seems like they are at risk for psychosis, we can evaluate them and offer them treatment,” Dr. Corcoran said. - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/can-an-algorithm-predict-schizophrenia

The Sydney Morning Herald – January 26 Natalie’s New World: How Gender Reassignment Is Moving into the Mainstream— Andrew Purcell Natalie Turner first realized something wasn’t quite right when she was three of four years old. She wasn’t Natalie then, but Christopher. In December 2017, at Mount Sinai’s Center for Transgender Medicine at Surgery, Natalie was prepping for her gender reassignment surgery. The surgery was performed by Jess Ting, MD, surgical director of Mount Sinai’s Center for Transgender Medicine and Surgery, Marci Bower’s a pelvic and gynecologic surgeon at the Center and Bella Avanessian, MD, a surgical fellow at the Center, who has been studying at Dr. Ting’s side for the past six months. The Center opened in March 2016, in response to new regulations requiring medical insurance plans to cover gender reassignment in New York. Zil Goldstein, a nurse specializing in HIV treatment and hormone therapy who is herself transgender, was appointed director. “I had patients who were forcing themselves to live in poverty so they could save up the money to get these surgeries,” she said. Within two months of opening there were 100 people on the waiting list, now, there are more than 400. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai - Marci Bowers, Professional Lecturer, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Pelvic and Gynecologic Surgeon, Mount Sinai’s Center for Transgender Medicine and Surgery - Zil Goldstein, MSN, Assistant Professor, Medical Education, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System - Bella Avanessian, MD, Surgery Fellow, Mount Sinai’s Center for Transgender Medicine and Surgery Learn more: http://www.smh.com.au/world/natalies-new-world-how-gender-reassignment-is-moving- into-the-mainstream-20171227-h0ag53.html Additional coverage: Daily Liberal http://www.dailyliberal.com.au/story/5192796/gender-reassignment-gives-natalie-a-new- world/?cs=5 MedicalHealthNew.net http://www.medicalhealthnews.net/natalie39s-new-world-how-gender- reassignment-is-moving-into-the-mainstream

Wave Newspapers – January 25 Health Matters: Toddler Develops, And Overcomes, Childhood Glaucoma — Mari Y. Lemelle The thought that a child could be affected by glaucoma can be frightening. Sebrina Cardoza though her three-month-old daughter Meagan was just suffering from allergies. Her eyes were getting larger, frequently watery and sensitive to light. After seeing three specialists, she found out it was glaucoma and never though her baby could get that disease. The reality is everyone is at risk for glaucoma, from infants to senior citizens. “In fact, childhood glaucoma occurs in one in 10,000 live births and more commonly affects males about 70 percent of the time,” said Joseph Panarelli, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and the glaucoma fellowship director at the New York Eye and Ear Infirmary of Mount Sinai. “It can be present at birth or occur within a child’s first year, when the drainage canal has not developed properly, trapping fluid in the eye, causing it to expand and bulge.” He added that careful observation of a child’s eyes is essential. To correct Meagan’s problem, Dr. Panarelli performed a 360-degre trabeculotomy with iScience microcatheter, a treatment performed in only a few eye centers nationwide. Meagan’s vision was saved due to her parents’ early detection and quick action, along with the ground-breaking surgical procedure performed by Dr. Panarelli. - Joseph Panarelli, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Associate Residency Program Director, Glaucoma Fellowship Director, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://wavenewspapers.com/health-matters-toddler-develops-overcomes-childhood- glaucoma/

DermWire – January 25 DermWireTV: Eczema Discovery – Ranna Jaraha Research out of the Icahn School of Medicine at Mount Sinai is closing in on a possible treatment for moderate to severe atopic dermatitis: IL-22 blockade. Their study, which appears in the Journal of the American Academy of Dermatology, provides the first evidence in humans showing that IL-22 is a key driver of atopic dermatitis. The experimental IL-22 blocker, Fezakinumab performed well in a study of 60 adults with moderate to severe disease when compared to placebo. The greatest improvements were seen among individuals with severe disease. “These cells may play a major role in this disease,” said study author, Emma Guttman-Yassky, PhD, professor of dermatology and clinical immunology, vice chair of research in the department of dermatology and the director of the Center for Excellence in Eczema at the Icahn School of Medicine at Mount Sinai. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://practicaldermatology.com/dermwire/tv/dermwiretv-eczema-discovery-ortho- dermatologics-revision-alastin-product-launches/

NBC New York – January 25 NYC Hospital Seeing 30 to 50 More Flu Patients Per Day This Season — Michael George and Sander Siegal The staff of Mount Sinai Children’s Hospital said they’ve been seeing between 30 and 50 more patients per day than normal this flu season. It comes amid a deadly outbreak that killed one New York boy already and left 1,600 other New Yorkers in the hospital last week alone. Peter Shearer, MD, medical director of the emergency department at The Mount Sinai Hospital and Katherine Bermudez, MSN, a clinical nurse in the emergency department at Mount Sinai are just two of the countless health professionals working tirelessly to help the influx of patients in recent weeks. “It seems like they’re coming in more this year, this season, than previous winter seasons,” Bermudez said. Dr. Shearer added, “This year, with this strain, what we find in in particular, the very young and the very old are the ones most susceptible and the most likely to get ill, particularly in the over 65 population.” - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital - Katherine Bermudez, MSN, Clinical Nurse, Emergency Department, The Mount Sinai Hospital Learn more: https://www.nbcnewyork.com/news/local/UES-Hospital-Seeing-More-Flu-Patients-Mount- Sinai-Pediatric-Influenza-471207083.html

U.S. News & World Report – January 25 Will Certain Foods Bolster Brain Health After Stroke? — Amy Norton Stroke survivors who eat plenty of leafy greens, fish and other healthy foods may help preserve their brain function as time goes on, a preliminary study suggests. Researchers found the benefits among stroke survivors who most closely followed the principles of the so-called "MIND" diet. It pulls together elements from two eating plans known to improve heart health: the traditional Mediterranean diet and the "DASH" diet, for controlling high blood pressure. The diet puts more value on vegetables – especially leafy greens – than fruit. And when people do eat fruit, the advice is to go heavy on berries, which studies have linked to less cognitive decline. Stroke survivors are at heightened risk of that kind of decline, as well as full-blown dementia. Their risk of dementia is roughly twice the norm, said Carolyn Brockington, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai and director of the stroke center at The Mount Sinai Hospital. Strokes occur when blood flow to the brain is suddenly reduced, Dr. Brockington explained. That can leave people with brain damage that impairs their thinking. Plus, stroke patients often have underlying conditions, like high blood pressure and heart disease that are linked to a higher dementia risk. So it's important to find ways to help preserve their brain function, said Dr. Brockington, who was not involved in the new study. - Carolyn D. Brockington, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai, Director, Stroke Center, The Mount Sinai Hospital Learn more: https://health.usnews.com/health-care/articles/2018-01-25/will-certain-foods-bolster-brain- health-after-stroke Additional coverage: Healthday https://consumer.healthday.com/cardiovascular-health-information-20/heart-stroke-related- stroke-353/will-certain-foods-bolster-brain-health-after-stroke-730491.html

Allure Magazine – January 25 Sunburn vs. Windbrun: What’s The Difference Between These Two Winter Skin Concerns? — Kaleigh Fasanella When it comes to skin woes, most of us have probably suffered from sunburn or windburn – or both – at one time or another. People tend to get the two confused seeing as they both end with the word “burn” and elicit similar symptoms, but believe it or not, they’re actually very different from one another. Windburn occurs as somewhat of an irritant dermatitis in that the wind hits the skin and pulls water out of the stratum corneum. Sunburn happens when we’re exposed to the sun’s harmful UV rays, which causes direct damage to our skin cells’ DNA and can result in discoloration and age spots down the line. You definitely want to avoid both ailments at all costs, but ultimately, sunburn is more severe when you consider its long-term effects. Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital, explained that with both windburn and sunburn, the skin becomes inflamed, but the cause, type of damage, and the treatment are different. “Windburn is essentially severe skin dryness with disruption of the skin barrier, leading to inflammation,” he said, adding that weather with low humidity puts a strain on the outer skin layer and microscopic cracks in the skin barrier can lead to loss of hydration and inflammation. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/what-is-windburn-sunburn-differences

Prevention – January 25 The Best Antioxidant Serums For Younger Looking Skin — Celia Shatzman There’s no such thing as a beauty miracle – but antioxidant serums come pretty close. “A serum is a skin care product with a gel or light lotion consistency that contains a high concentration of performance ingredients,” said Debra Jaliman, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. “Antioxidant specific serums are ones that prevent free radical damage and inhibit oxidation. Free radicals cause damage to the DNA and our cells. Antioxidants complex the free radicals, which are missing a molecule, and neutralize them.” Besides delivering advanced protection, there are plenty of other reasons to use an antioxidant serum. “They improve the appearance of fine lines and wrinkles and the overall texture of the skin,” Dr. Jaliman says. “It’s a great treatment for those worried about aging skin. Antioxidants also help boost the immune system from inside and out.” - Debra Jaliman, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.prevention.com/beauty/best-antioxidant-serums

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 29, 2018 Date: Monday, January 29, 2018 1:26:08 PM Attachments: ATT00001.txt

In the News January 29, 2018

Science Codex – January 26 Aspiration As Good As Stent Retrievers For Large Vessel Cloth Removal In Stroke Patients A new study, co-led by researchers at the Icahn School of Medicine at Mount Sinai and presented at the main event plenary session at the International Stroke Conference (ISC) 2018, has found that patients suffering a large vessel occlusion stroke, the most devastating kind of ischemic stroke, do just as well when treated with a direct aspiration first pass (ADAPT) approach than those treated with a stent retriever first-line approach. Stent retrievers are the current standard of care for mechanical thrombectomy in patients suffering acute ischemic strokes. "Our data strongly demonstrates that the two approaches are clinically equivalent, meaning that patients do just as well when you start with aspiration, or clot suction, as when you start with a stent retriever to trap and pull out the clot," said J Mocco, MD, MD, professor of neurosurgery at the Icahn School of Medicine at Mount Sinai, director the cerebrovascular center at The Mount Sinai Hospital, and vice chair of neurosurgery for the Mount Sinai Health System. Dr. Mocco designed the study and presented the data at ISC 2018. "COMPASS is the first trial designed to compare patient functional outcome between these treatment approaches and we found that patients do equally well with either treatment." Dr. Mocco added that this study is very exciting because it shows that there are other ways to open the arteries that are just as effective and perhaps, less expensive. - J Mocco, MD, MS, Professor, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, The Cerebrovascular Center, Mount Sinai Hospital, Vice Chair, Neurosurgery, The Mount Sinai Health System Learn more: http://www.sciencecodex.com/aspiration-good-stent-retrievers-large-vessel-clot-removal- stroke-patients-618591 Additional coverage: TCT MD https://www.tctmd.com/news/highly-anticipated-compass-results-boost-aspiration-acute- ischemic-stroke MedPage Today https://www.medpagetoday.com/meetingcoverage/isc/70778 Medscape https://www.medscape.com/viewarticle/891901 Health News Digest http://www.healthnewsdigest.com/news/Stroke0/Aspiration-As-Good-As-Stent- Retrievers-for-Removal-of-Large-Vessel-Clots-in-Ischemic-Stroke-Patients-Mount-Sinai-Researchers- Find.shtml Science Newsline http://www.sciencenewsline.com/news/2018012718370065.html

The Daily Telescope – January 29 George D. Dangas Presented With The Albert Nelson Marquis Lifetime Achievement Award By Marquis Who’s Who — Jasmine Petters Marquis Who’s Who, the world’s premier publisher of biographical profiles is proud to present George D. Dangas, MD, PhD, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and director of cardiovascular innovation at the Zena and Michael A. Weiner Cardiovascular Institute at the Mount Sinai Health System, with the Albert Nelson Marquis Lifetime Achievement Award. An accomplished listee, Dr. Dangas celebrates many years of experience in his professional network, noted for achievements, leadership qualities, and the credentials and successes he has accrued in his field. With more than 25 years of industry experience, Dr. Dangas has worked in multiple roles for the Icahn School of Medicine at Mount Sinai. As in all Marquis Who’s Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in the field are all taken into account during the selection process. - George D. Dangas, MD, PhD, Professor, Medicine, Cardiology, Surgery, Icahn School of Medicine at Mount Sinai, Director, Cardiovascular Innovation, The Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai Health System Learn more: https://dailytelescope.com/pr/george-d-dangas-presented-with-the-albert-nelson-marquis- lifetime-achievement-award-by-marquis-whos-who/49906

Healio – January 29 Computer-Based Analysis Of Language May Predict Psychosis Onset — Savannah Demko A computer-based natural language processing analyses of speech transcripts predicted — with 83 percent accuracy — young people at risk for developing later psychosis, researchers found. “Language disturbance is prevalent in schizophrenia and is related to functional disability, given that an individual needs to think and speak clearly in order to maintain friends and a job,” said Cheryl Corcoran, MD, senior faculty of psychiatry and program leader of psychosis risk at the Icahn School of Medicine at Mount Sinai. “Beyond clinical ratings, there has been an effort to characterize early subtle language disturbances in clinical high-risk individuals using linguistic analysis, with the aim of improving prediction. While this manual linguistic approach appears to be superior to clinical ratings in psychosis prediction, the method depends on predefined measures that may not capture other subtle language features.” Dr. Corcoran added that “The results of this study are exciting because this technology has the potential to improve prediction of psychosis and ultimately help us prevent psychosis by helping researchers develop remediation and training strategies that target the cognitive deficits that may underlie language disturbance.” - Cheryl Corcoran, MD, Senior Faculty, Psychiatry, Program Leader, Psychosis Risk, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/psychiatry/schizophrenia/news/online/%7Bf8a9e8c6-6985-4238- 8a55-10932d78a574%7D/computer-based-analysis-of-language-may-predict-psychosis-onset

Reuters – January 26 Bright Light Therapy May Help Fatigued Cancer Survivors Sleep Better — Lisa Rapaport Cancer survivors often suffer from chronic fatigue, and when they do, a new study suggests that waking up to bright white light may help them sleep better. It’s possible that the bright white light helps cancer survivors reset their internal clocks, or circadian rhythms, so that their body can more easily rest at night and wake during the day, said study leader, Lisa Wu, PhD, Adjunct assistant professor or population health science and policy at the Icahn School of Medicine at Mount Sinai. “Cancer survivors and even other individuals who spend most of their days indoors may not receive enough bright light to keep their biological rhythms synchronized,” Dr. Wu said. “Given that light exposure from being outside is generally much brighter than light received indoors, the addition of artificial bright light each morning helps cancer survivors reduce fatigue and improve their sleep quality by strengthening their circadian rhythms.” - Lisa M. Wu, PhD, Adjunct Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-cancer-sleep/bright-light-therapy-may-help- fatigued-cancer-survivors-sleep-better-idUSKBN1FF2QY Additional coverage: Photonics https://www.photonics.com/a63042/Bright_Light_Therapy_Improves_Sleep_in_People

CNBC News – January 26 Scientists Are Now Rushing To Develop A Universal Flu Vaccine— Bob Woods The nation's battle against this year's nasty influenza epidemic rages on as government health agencies and drug companies rush to develop a universal flu vaccine that can protect against multiple stains of the flu. The definition of a universal flu vaccine is somewhat flexible. Ideally, a single injection would protect against all known and emerging influenza A strains and last a lifetime, said Peter Palese, PhD, professor and chair of microbiology and professor of infectious diseases at the Icahn School of Medicine at Mount Sinai. More modest proposals envision a one-shot vaccine that would protect against getting the flu for anywhere from three to 20 years. Dr. Palese's laboratory is one of three different research groups at Mount Sinai exploring a universal flu vaccine and one of numerous efforts under way mostly in academia, biotech firms and NIH. Dr. Palese's vaccine aims to stimulate antibodies that bind to the more "conserved" areas on the stalk and which remain the same every year and are common to most seasonal flu viruses. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.cnbc.com/2018/01/26/scientists-are-now-rushing-to-develop-a-universal-flu- vaccine.html

Bustle – January 26 How To Not Give The Flu To Someone Else If You Have It — Brandi Neal You did everything you were supposed to do, but you still came down with the dreaded flu. Aside seeking out remedies to make yourself feel better, it’s also important to consider how to avoid getting other people sick if you have the flu. Flu season is one of the times when being selfish is encouraged. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital, said that if you live with other people, sharing can put them at risk. “You sort of hate to, but during flu season, it’s probably more hygienic to have people drying their hands on paper towels,” Dr. Shearer said. Additionally, don’t share bath towels, food, silverware, dishes, or any type of other household item. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: https://www.bustle.com/p/how-to-not-give-the-flu-to-someone-else-if-you-have-it-8030696

Chemical & Engineering News – January 29 Uncovering The Hidden Signs Of Organ Transplant Rejection— Celia Henry Arnaud More than 33,000 organs were transplanted in the U.S. in 2016, the most recent year for which data are available, according to the United Network for Organ Sharing. After a transplant, a recipient’s immune system fights against the organ, recognizing it as foreign. As many as 15 percent of people receiving kidney transplants, for instance, experience acute rejection, meaning that the immune system sends in its troops and causes inflammation within the first year. Rejection episodes like these are usually treatable and reversible. Biomarkers that indicate how a person’s immune system is functioning could help guide doctors in prescribing the correct dose of immunosuppressants for individual transplant patients to help ward off acute rejection. And they might someday help develop a treatment for chronic rejection. “Most transplants are treated the same,” said Peter S. Heeger, MD, professor of medicine, nephrology, and director of transplant research at the Recanati Miller Transplant Institute at the Icahn School of Medicine at Mount Sinai. At most center, he said, patients receive therapy to dial down the immune system at the time of the transplant. After the transplant, they receive multiple immunosuppressant drugs. - Peter S. Heeger, MD, Professor, Medicine, Nephrology, Director, Transplant Research, Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai Learn more: https://cen.acs.org/articles/96/i5/uncovering-the-hidden-signs-of-organ-transplant- rejection.html

Glamour Magazine – January 26 How To Talk To Children About Abuse In The Wake Of The Larry Nassar Trial — Ashley Mateo Last week, more than 150 women – including Olympians Aly Raisman and McKayla Maroney – testified in the Larry Nassar trial that Nassar, a former USA Gymnastics and Michigan State University doctor, sexually abused them. Nassar was sentence to 40 to 175 years in prison, bringing the trial to an end, but the testimony from that courtroom will have a lasting impact on women worldwide – both the survivors and those who heard their words. One of the most common refrains in many of the women’s testimonials was how they had always been told no one could touch them “down there” – except a doctor. But Nassar was a doctor – one who preyed on that exact mentality and trust to take advantage of his patients. Surely many parents heard these words and wondered if they should rethink how they talk to their daughters about sexual abuse and safety. While different ages require different approaches, you want to teach your kids about your bodies, someone else’s body, and the concept of boundaries and personal space, said Susan F. Abbott, MD, assistant clinical professor of psychiatry at the Icahn School of Medicine at Mount Sinai. “By doing that, you’re giving them the language to communicate so that if something should occur, they have the tools to not keep it to themselves or be swallowed up by shame and fear,” she said. She added that “the one thing you want to teach your kids is not to be silent, and as a parent, you’re the one who has to give them the language to tell someone what happened.” - Susan F. Abbott, MD, Assistant Clinical Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.glamour.com/story/talking-to-children-about-abuse-after-larry-nassar-trial

Allure Magazine – January 26 Is Higher SPF Sunscreen Better? This Study Thinks So — Macaela Mackenzie It would seem intuitive that a higher SPF sunscreen would mean more protection right? But official sunscreen wisdom currently said it doesn’t make a real difference – the debate is enough that “there is controversy right now in the FDA on whether SPF 100-plus should be allowed on the label of sunscreens,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. According to a new study, using a higher SPF really can make a big difference. You get double the sun exposure when you opt for SPF 15 instead of SPF 30. To give you a visual, “a product with an SPF 30 means that you get the same amount of sun exposure after 30 minutes outside as you would get if you were unprotected outdoors for one minute,” Dr. Zeichner said. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/is-higher-spf-sunscreen-better-study

Metro New York – January 26 Ask Mount Sinai: Understanding The Thyroid Gland — Sheila Dougherty The thyroid gland, which sits at the center of our lower necks, is a small organ. But it has a big job — it’s part of the endocrine system, which affects many other systems in our bodies. According to the American Thyroid Association, an estimated 20 million Americans are living with some sort of thyroid disorder, and of that number, 60 percent are unaware of it. Ilya Likhterov, MD, an otolaryngologist at Mount Sinai Union Square said, “A thyroid is a gland. You can think of it as a gas pedal for the body. When the thyroid hormone goes up, the energy consumption of the body increases; when the thyroid hormone is down, the energy consumption slows down.” He added that weight gain, sleepiness, fatigue, and hair loss are symptoms of a low thyroid hormone. Dr. Likhterov explained that overall, be in touch with any changes to your body. “As with anything, having a well-balanced diet and exercise certainly affects all organ systems, and everything is interrelated. So a good maintenance lifestyle and diet is really the best that we can do.” - Ilya Likhterov, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Otolaryngologist, Mount Sinai Union Square Learn more: https://www.metro.us/body-and-mind/health/thryoid-health

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 30, 2018 Date: Tuesday, January 30, 2018 11:39:27 AM Attachments: ATT00001.txt

In the News January 30, 2018

South Florida Hospital News – January 29 Mount Sinai Health System Expands Innovative Care In Florida— Charles Felix Mount Sinai Health System announced the opening of a new state-of-the-art medical practice in Palm Beach, Florida, bringing world-class innovative care to patients and businesses in the region. Mount Sinai Doctors Palm Beach, centrally located on North Flagler Drive in West Palm Beach, will offer primary care, cardiology, gastroenterology, and ophthalmology services. “This is a significant step in expanding the reach of Mount Sinai New York’s innovative high-quality care in South Florida,” said Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System. “Residents of Palm Beach County and patients who travel between Florida and New York now have streamlined access to care from Mount Sinai’s outstanding physicians in a broad array of specialties.” The compassionate and highly trained physician staff will be led by prominent cardiovascular specialist Gonzalo Loveday, MD, FACC, who will be the practice’s medical director. “The staff and clinical leadership at Mount Sinai Doctors Palm Beach have been carefully chosen from a large pool of national applicants and are dedicated to providing comprehensive, highest-quality care to their patients,” said Arthur Klein, MD, president of the Mount Sinai Health Network. “We are proud to provide the resources of our nationally and internationally recognized academic health care system to benefit the residents and businesses of Palm Beach County.” - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - Gonzalo J. Loveday, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Chief Medical Director, Mount Sinai Heart New York at Jupiter Medical Center, Medical Director, Mount Sinai Doctors Palm Beach - Arthur Klein, MD, President, Mount Sinai Health Network Learn more: http://www.southfloridahospitalnews.com/page/Mount_Sinai_Health_System_Expands_Innovative_Care_in_Florida/12362/25/ Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180130/PULSE/180139999/maimonides-partners-with-new- york-community-hospital-on-clinical-care (Subscription Required) Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/01/30/budget- proposal-expands-ems-role-028971 News Medical & Life Sciences https://www.news-medical.net/news/20180130/Mount-Sinai-Health-System-opens-new-state- of-the-art-medical-practice-in-Florida.aspx

Bklyner – January 29 Mount Sinai Opens Urgent Care Center In DUMBO— Pamela Wong Mount Sinai hosted a ribbon-cutting ceremony last week to celebrate the opening of its new state-of-the-art urgent care center in Dumbo. Located at 110 York Street, Mount Sinai Urgent Care Dumbo offers walk-in service and personalized treatment for temporary and chronic medical conditions. An appointment is not required to see the staff of Mount Sinai physicians at the new center featuring five modern exam rooms and upgraded technology including an X-ray facility. The Urgent Care Center’s electronic medical records system is fully integrated with Mount Sinai Health Systems, providing staff with secure access to each patient’s medical history. “When accidents and illnesses occur unexpectedly, New Yorkers need urgent care,” said Judah Fierstain, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of Mount Sinai Doctors Urgent Care. “The opening of this facility means residents will have access to Mount Sinai’s high-quality medical care.” - Judah Fierstein, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Mount Sinai Doctors Urgent Care Learn more: https://bklyner.com/mount-sinai-opens-urgent-care-center-dumbo-phoenix-house-selling-two-jay-street- properties/

Times Ledger – January 30 Simotas Announces One Million Investment In Further Mount Sinai Queens Expansion— Bill Parry Assemblywoman Aravella Simotas secured one million dollars in capital funding for three projects at Mount Sinai Queens in Astoria that she nominated for support from the New York State Assembly. The investment helps further an expansion that includes a five-story pavilion with new operating suites, facilities for primary care and an expanded emergency room with an off-street ambulance bay. “Mount Sinai Queens continues to transform health care in our great borough,” said Caryn Schwab, executive director of Mount Sinai Queens. “The expansion of services in our new state-of-the-art pavilion has allowed us to improve the quality and complexity of health care offered right here in Queens. We couldn’t do this without great partners like Assembly Member Aravella Simotas. The funding she’s helped secure is going to make a real difference in the lives of our residents. We are incredibly grateful for her efforts and support.” - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: https://www.timesledger.com/stories/2018/4/mountsinai_2018_01_26_q.html

ABC News – January 29 Kenneth Rainin Foundation Awards $1.7 Million To Improve IBD Patient Outcomes The Kenneth Rainin Foundation has awarded $1.7 million in grants through its Synergy Awards System. Funding will support teams of researchers who are pursuing collaborative projects aimed at improving the prediction and prevention of Inflammatory Bowel Disease (IBD). The Synergy Awards encourages investigators with differing areas of expertise to pool their talents and resources toward a research goal that would not be possible if they worked independently. Inga Peter, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai and Jean-Frederic Colombel, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of the Susan and Leonard Feinstein IBD clinical center at Mount Sinai, are working together with other experts to study the role of IBD in the fungal microbiota transmission from pregnant women to offspring. Saurabh Mehandru, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai is working toward identifying the unique pathology that explains ulcerative colitis distribution. Both groups have received grants for this research by this foundation. - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai - Jean-Frédéric Colombel, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai - Saurabh Mehandru, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: http://www.abc6.com/story/37371832/kenneth-rainin-foundation-awards-17-million-to-improve-ibd-patient- outcomes Additional coverage: KHQ News http://www.khq.com/story/37371832/kenneth-rainin-foundation-awards-17-million-to-improve-ibd-patient- outcomes WRCB TV http://www.wrcbtv.com/story/37371832/kenneth-rainin-foundation-awards-17-million-to-improve-ibd-patient- outcomes KSLA http://www.ksla.com/story/37371832/kenneth-rainin-foundation-awards-17-million-to-improve-ibd-patient-outcomes NBC 12 News http://www.nbc12.com/story/37371832/kenneth-rainin-foundation-awards-17-million-to-improve-ibd-patient- outcomes

The Scientist – January 29 How To Build A Better Flu Shot — Ashley Yeager Researchers have long sought a flu vaccine that would protect an individual season after season with just a single injection, similar to the measles or chickenpox vaccines. But unlike those viruses, the influenza virus has many rapidly mutating strains. To create a more effective flu vaccine, hemagglutinin has been a prime target. If a vaccine can prevent hemagglutinin from attaching to and infecting host cells, that could stop the virus in its tracks. Scientists are also interested in the stalk of hemagglutinin, which is important for allowing the virus to release its genome into a host cell. “That’s what starts the infection,” said Florian Krammer, PhD, associate professor of microbiology at the Icahn School of Medicine at Mount Sinai. To infect the cell, the stalk of the hemagglutinin mushroom becomes completely rearranged from its normal state. “It’s a machine,” Dr. Krammer explained. “It doesn’t tolerate mutations well. If you introduce mutations, you destroy the machine, so the virus doesn’t like to change it.” Because the stalk doesn’t like change, it is a good part of the virus to target when making a vaccine. Dr. Krammer and colleagues have developed a hemagglutinin molecule with a head from various strains of flu that do not circulate in humans and a stalk from a strain such as H1N1. - Florian Krammer, PhD, Associate Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/51513/title/How-to-Build-a-Better-Flu-Shot/

The Hill – January 30 Tough Flu Season Could Kill Tens Of Thousands — Reid Wilson Millions of Americans are suffering from the influenza virus in what public health experts say is an unusually active and dangerous flu season, the result of several distinct strains of a disease that are likely to kill tens of thousands. The influenza virus is among the public health community’s greatest concerns. It is easily communicable, infecting tens if not hundreds of millions of people across the globe every year. And the right strain could also kill a significant number of those infected. “The strains which are circulating right now are not completely matched with respect to what is in the vaccine,” said Peter Palese, PhD, chair of microbiology and professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. “There’s an inherent problem that we have to decide in February basically what kind of vaccine will be produced. These variants drift away sometimes.” Dr. Palese said there is some hope in the data that suggests this year’s flu season may not be as bad as previous years. The infection curve, which shows how many cases have been reported over a given period of time, is beginning to slow, he said. “I think there is some indication that there is already less of an increase this week compared to two weeks ago.” - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://thehill.com/homenews/state-watch/371310-tough-flu-season-could-kill-tens-of-thousands

MedPage Today – January 29 Molecular Imaging Flags Risk Of AAA Rupture — Nicole Lou Uptake of 18F-sodium fluoride (18F-NaF) can point to active vascular calcification associated with high-risk atherosclerotic plaque and may be a marker of high-risk abdominal aortic aneurysms (AAAs), according to a molecular imaging study. This is the first study to demonstrate that an imaging biomarker of disease activity can add to the risk prediction of AAA and to suggest that this approach might refine clinical decisions regarding the need for surgery and improve patient outcomes. Jagat Narula, MD, PhD, associate dean of global health, professor of medicine, radiology, cardiology, chair of cardiology and director of the cardiovascular imaging program at the Zena and Michael A. Wiener Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, emphasized that “earlier detection of high-risk aneurysms is important to render appropriate care to the highest risk patients.” He added, “Despite significant advances in aortic imaging, pharmacotherapy and surgical interventions over the past decade, patients with AAA complications continue to have high rates of mortality. Noninvasive molecular imaging holds promise to identify markers of aortic instability earlier in the course of disease progression, and could offer a major advance in the diagnosis, surveillance and management of AAA.” - Jagat Narula, MD, PhD, Associate Dean, Global Health, Professor, Medicine, Radiology, Cardiology, Philip J. and Harriet L. Goodhart Chair, Cardiology, Director, Cardiovascular Imaging Program, Mount Sinai’s Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/cardiology/atherosclerosis/70817

Healio – January 29 Idasanutlin Active In Refractory Polycythemia Vera— Mark Leiser Idasanutlin demonstrated clinical activity among patients with refractory polycythemia vera, according to study results presented at ASH Annual Meeting and Exposition. John O. Mascarenhas, MD, associate professor of medicine, hematology and medical oncology, director of the adult leukemia program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and colleagues conducted a single-institution phase 1 dose-escalation trail that included 12 patients with JAK2V617F-positive polycythemia vera or essential thrombocythemia. Seven of the 12 patients were women; median patient age was 64 years old. Dr. Mascarenhas and colleagues assessed bone marrow pathologic response in two patients after five cycles. The researchers reported a significant increase in percentage of mononuclear cells expressing MDM2 among study participants compared with normal controls. A multicenter phase 2 study is underway to evaluate idasanutlin at the 150-mg daily dose. - John O. Mascarenhas, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Director, Adult Leukemia Program, Leader, Clinical Investigation within Myeloproliferative Disorders Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/hematology-oncology/myeloproliferative-neoplasms/news/online/%7B40fbd79d-287a- 4bd7-be55-ad18e0e8da28%7D/idasanutlin-active-in-refractory-polycythemia-vera

Asbestos – January 29 Talc Pleurodesis A Viable Option For Mesothelioma — Tim Povtak Some patients with mesothelioma should consider the less-invasive talc pleurodesis procedure instead of aggressive, tumor- removing surgery, based on recent research from experts at The Mount Sinai Hospital. Although talc plurodesis is considered only palliative, survival time often is not significantly different between the two procedures, according to the study published by Journal of Thoracic Disease. “There should be comprehensive conversation with your physician about treatment options, not only about survival, but about quality of life,” said Emanuela Taioli, MD, PhD, director of the institute for translational epidemiology, and professor of thoracic surgery, population health science and policy at the Icahn School of Medicine at Mount Sinai. “Going through this kind of thoracic surgery is an extensive process.” Dr. Taioli led a group of researchers including Maaike A. Van Gerwen, MD, medical student at the Icahn School of Medicine at Mount Sinai and Raja Flores, MD, professor in thoracic surgery, director the thoracic surgical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and system chair of thoracic surgery for the Mount Sinai Health System. “A person may choose to do the talc, knowing survival might be a little shorter, but clearly the quality of life may be better by avoiding major surgery,” Dr. Taioli said. “Unless the doctor tells you, ‘This is such a favorable case, and I can promise you a much longer life with surgery,’ talc pleurodesis might be something to consider,” Dr. Taioli added. - Emanuela Taioli, MD, PhD, Director, Institute for Translational Epidemiology, Professor, Population Health and Policy, Thoracic Surgery, Icahn School of Medicine at Mount Sinai - Maaike A. Van Gerwen, MD, Medical Student, Icahn School of Medicine at Mount Sinai - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://www.asbestos.com/news/2018/01/29/talc-pleurodesis-mesothelioma-surgery/

Democrat Gazette – January 29 Healthy Lifestyle And Luck = Best Defenses? — Karen Weintraub What makes people sick is a combination of back luck – exposures to viruses or other pathogens – and the state of their immune system, said Talia Swartz, MD, PhD, assistant professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai. Someone with a weakened immune system is more likely to be more vulnerable to passing bugs than someone with a healthy one. “There are definitely different types of patients who are more resistant to infections or who have slower progression of infectious diseases based on certain immune features we recognize that make them have a stronger immune system,” she said. Frequent hand washing is crucial for keeping bugs from entering the mouth, nose, and eyes, where they can spread infections. Dr. Swartz also recommends vaccinations, which help train the immune system to protect the body. The immune system’s responsiveness typically declines with age. If someone is eating well, exercising, getting a good amount of sleep and avoiding unnecessary stresses, they are less likely to get ill, and if they do get ill, have better outcomes. - Talia Swartz, MD, PhD, Assistant Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: http://www.nwaonline.com/news/2018/jan/29/healthy-lifestyle-luck-best-defenses-20/?features

HealthDay – January 29 Memory Loss Hitting Some Fentanyl Abusers— Dennis Thompson Using fentanyl or other opioids alongside other illicit drugs could trigger possibly permanent amnesia caused by brain damage, doctors warn. Over a dozen cases have emerged in which drug abusers have developed severe short-term memory loss, possibly after experiencing an overdose. These observations are new, very unusual and quite troubling, said Timothy Brenna, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the Fellowship in Addiction Medicine Program at the Addiction Institute of Mount Sinai West. “I’ve not seen that with other opioids. I have patients who have abused heroin for years and they've never complained of that or shown any signs of that," Dr. Brennan said. "This is very unique. This is nothing I've seen before." Because fentanyl is so potent and cheaper than heroin, Dr. Brennan said, many drug traffickers have taken to cutting heroin with the synthetic. Unsuspecting buyers wind up taking a drug cocktail that's much more powerful than they expect. "As the fentanyl starts being combined with heroin, it's creating a huge increase in accidental overdoses," Dr. Brennan added. The sad part is these memory problems might doom drug users to a lifetime of addiction, since they can’t learn from their mistakes. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://consumer.healthday.com/bone-and-joint-information-4/fentanyl-news-828/memory-loss-hitting-some- fentanyl-abusers-730613.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-01-memory-loss-fentanyl-abusers.html The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay730613_20180129_Memory_Loss_Hitting_Some_Fentanyl_Abusers.html

Journal of Clinical Pathways – January 29 Updated Lung Cancer Molecular Testing Guideline Highlights New Genes — Marilynn Larkin An update to the 2013 guideline for the molecular analysis of lung cancers provides new recommendations that include testing for additional genes and the use of ultrasensitive assays and other new technologies, according to an expert panel report. Raja Flores, MD, professor in thoracic surgery, director the thoracic surgical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and system chair of thoracic surgery for the Mount Sinai Health System, said, “While many clinicians in the United States have already incorporated many of these recommendations into their practice, this evidence-based, updated guideline - collaboratively developed by an international, multidisciplinary panel of expert authors . . . will continue to advance the quality of diagnostic medicine to improve lung cancer patient outcomes.” - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://www.journalofclinicalpathways.com/news/updated-lung-cancer-molecular-testing-guideline-highlights- new-genes-technologies

Healio – January 30 The Challenge Of CLI: Endovascular Tibial Interventions Show Promise — Erik Swain Patients with critical limb ischemia and below-the-knee lesions are notoriously difficult to treat, and the most common tibial endovascular intervention, percutaneous transluminal angioplasty, often does not provide a long-term solution. Therefore, there is great interest in other endovascular tibial interventions beyond percutaneous transluminal angioplasty. Certain data on the use of atherectomy and drug-eluting stents have been encouraging, whereas drug-eluting balloons have not yet shown to be effective in this patient population. Different atherectomy devices have successfully treated different kinds of tibial lesions, but operators should not assume one device will work for all patients with CLI, said James F. McKinsey, MD, professor of surgery at the Icahn School of Medicine at Mount Sinai, during a presentation at VIVA 2017 in Las Vegas. “Atherectomy definitely has a role in the treatment of patients with critical limb ischemia below the knee,” he told the audience. - James F. McKinsey, MD, Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/cardiac-vascular-intervention/limb-salvage/news/print/cardiology-today- intervention/%7B3999eb10-ec5e-4ee8-be0c-07b3e09dd308%7D/the-challenge-of-cli-endovascular-tibial-interventions-show- promise

Self Magazine – January 29 How To Heal The Roof Of Your Mouth After You’ve Burned It — Korin Miller You know the feeling: you accidentally take a swig of scalding hot coffee or go for an aggressive bite of just-delivered pizza and immediately regret it. The roof of your mouth, called the palate, is covered with skin. And, just like skin on any other part of your body, the skin in your mouth can experience first, second, and third-degree burns, said Gary Goldenberg, MD, assistant professor of dermatology and pathology at the Icahn School of Medicine at Mount Sinai and director of the dermatology faculty practice at the Mount Sinai Hospital. First-degree burns are the mildest and they impact the outer layer of skin. These burns usually just cause redness, said Dr. Goldenberg. Second-degree burns are more severe and impact the epidermis and dermis. These burns can cause pain, redness, swelling and blistering. Third-degree burns are the most intense. They go through the epidermis and dermis and impact tissues below that. These burns can leave your skin white or black, and can even make it feel temporarily numb. - Gary Goldenberg, MD, Assistant Professor, Dermatology, Pathology, Icahn School of Medicine at Mount Sinai, Director, Dermatology Faculty Practice, The Mount Sinai Hospital Learn more: https://www.self.com/story/how-to-heal-the-roof-of-your-mouth-after-youve-burned-it

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - January 31, 2018 Date: Wednesday, January 31, 2018 1:36:47 PM Attachments: ATT00001.txt

In the News January 31, 2018

The New York Times – January 30 Like Fevers, The Number Of Flu Patients Is Rising — Luis Ferre-Sadurni Thousands of Americans nationwide are grappling with what officials say is turning out to be the worst flu season in nearly a decade. The uptick was crowded emergency rooms across the state, forcing some hospitals to temporarily divert ambulances and hire more staff. Officials are urging New Yorkers to get vaccinated and some have called on the federal government to ratchet up its efforts in New York. The influx of flu patients can strain New York City hospitals because emergency departments in urban areas tend to be smaller than others across the state, said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital. “It’s definitely more crowded at my emergency department, and it does put a bit of stress on the system,” Dr. Shearer added. He stated that hospitals across the Mount Sinai Health System have seen a jump in people over the age of 65 with influenza. In turn, he has increased the number of physician assistants and doctors working each shift. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: https://www.nytimes.com/2018/01/30/nyregion/flu-season-new-york.html

Politico New York – January 31 What Do You See? — Dan Goldberg A Mount Sinai researcher, James Tsai, MD, president of the New York Eye and Ear Infirmary of Mount Sinai, professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and system chair of ophthalmology at the Mount Sinai Health System, released an analysis of the evolving eye care industry in the Journal of Academic Ophthalmology. Ophthalmologists and optometrists are the two major service providers in the industry. While the markets for both professions are currently fragmented, the wave of consolidation and commoditization in health care will likely catch up to eye care in coming years. Scope of practice legislation continues to be a topic of heated debate. As it evolves, consolidated practices will move toward an integrated model that uses both types of providers to meet demand. - James Tsai, MD, President, New York Eye and Ear Infirmary of Mount Sinai, Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, System Chair, Ophthalmology, Mount Sinai Health System Learn more: https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/01/31/suny-concerns-with-cuomos-budget-029376

Becker’s ASC Review – January 30 Mount Sinai Health System Opens New Florida Medical Practice: Four Insights — Eric Oliver New York City-based Mount Sinai Health System opened Mount Sinai Doctors Palm Beach focused on bringing primary care, cardiology, gastroenterology and ophthalmology services to the area. Gonzalo Loveday, MD, assistant professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, and chief medical director of Mount Sinai Heart New York at Jupiter Medical Center, will serve as the practice’s medical director. It will be serviced by nine other physicians. The practice will cater to patients who frequently travel between New York City and Palm Beach. The expansion is part of Mount Sinai’s attempt to grow its national healthcare presence. Arthur Klein, MD, president of the Mount Sinai Health Network, said, “The staff and clinical leadership at Mount Sinai Doctors Palm Beach have been carefully chosen from a large pool of national applicants and are dedicated to providing comprehensive, highest-quality care to their patients. We are proud to provide the resources of our nationally and internationally recognized academic health care system to benefit the residents and businesses of Palm Beach County." - Gonzalo J. Loveday, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Chief Medical Director, Mount Sinai Heart New York at Jupiter Medical Center, Medical Director, Mount Sinai Doctors Palm Beach - Arthur Klein, MD, President, Mount Sinai Health Network Learn more: https://www.beckersasc.com/gastroenterology-and-endoscopy/mount-sinai-health-system- opens-new-florida-medical-practice-4-insights.html

New Jersey Biz – January 30 Valley-Mount Sinai Launches New, Novel Breast Cancer Treatment — Vince Calio Valley-Mount Sinai Comprehensive Cancer Care has launched a new breast cancer treatment called “breast IORT” to deliver radiation treatment to patients in the operating room following surgery to remove breast tumors. The lumpectomy treatment is intended to eliminate the need for weeks of post- surgery chemotherapy, which should translate to shorter post-surgery treatment times, fewer side effects, reduced costs and an improved quality of life for breast cancer sufferers. “The IORT procedure uses a miniaturized X-ray source to deliver a full course of targeted radiation from inside the body, directly within the tumor cavity where the cancer is most likely to recur,” said Michael Wesson, MD, clinical assistant professor of radiation oncology at the Icahn School of Medicine at Mount Sinai and co-director of radiation oncology for Valley-Mount Sinai Comprehensive Cancer Care. “This destroys cancer cells while reducing the risk of damage to nearby healthy tissues, including the heart, lungs, and ribs.” Chad DeYoung, MD, clinical assistant professor of radiation oncology at the Icahn School of Medicine at Mount Sinai and co-director of radiation oncology for Valley-Mount Sinai Comprehensive Cancer Care said, “This helps to minimize potential side effects, which are more common with whole breast irradiation.” - Michael Wesson, MD, Clinical Assistant Professor, Radiation Oncology, Icahn School of Medicine at Mount Sinai, Co-Director, Radiation Oncology, Valley-Mount Sinai Comprehensive Cancer Care - Chad DeYoung, MD, Clinical Assistant Professor, Radiation Oncology, Icahn School of Medicine at Mount Sinai, Co-Director, Radiation Oncology, Valley-Mount Sinai Comprehensive Cancer Care Learn more: http://www.njbiz.com/article/20180130/NJBIZ01/180139985/valleymount-sinai-launches- new-novel-breast-cancer-treatment

Onc Live – January 30 Dr. Oh On Abiraterone Versus Docetaxel In Prostate Cancer — William K. Oh, MD William K. Oh, MD, professor of medicine, hematology, medical oncology and urology, and deputy director of the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai discusses the abiraterone acetate versus docetaxel for patients with prostate cancer. The use of abiraterone and docetaxel were established in castration-resistant prostate cancer. In that setting, there is conversation combining those agents, explained Dr. Oh. According to Dr. Oh, many oncologists have the bias to give chemotherapy upfront to patients that have an aggressive disease or are poorly differentiated. There is no current data to suggest that, but it is something to consider when determining a treatment strategy for patients. - William K. Oh, MD, Professor, Medicine, Hematology, Medical Oncology, Urology, Deputy Director, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.onclive.com/onclive-tv/dr-oh-on-abiraterone-versus-docetaxel-in-prostate- cancer

Genetic Engineering & Biotechnology News – January 30 Gene Therapy May Not Be A Viable Option For Many Patients — Christina Bennett Gene therapies offer the promise of a one-time cure for genetic diseases, but they have to make it past the immune system first. For gene therapies that are infused directly into the body, that is, in vivo gene therapies, a large fraction of people have immune systems that are primed with pre-existing neutralizing antibodies to gene therapies in clinical development. The reason people commonly have pre-existing antibodies to a gene therapy is because the vector used to ferry the therapeutic cargo is often of viral origin. Viral vectors include oncoretroviruses, lentiviruses, adenoviruses, adeno-associated viruses (AAV), and herpes viruses. For genetic diseases, one vector has taken the lead. Right now, AAV is “by far” the leading vector for in vivo gene therapies designed to correct a genetic mutation, said Thomas Weber, PhD, associate professor of medicine, cardiology, microbiology, cell, developmental and regenerative biology at the Icahn School of Medicine at Mount Sinai. “Most of us at some point get infected by AAV because AAV is a nonpathogenic virus,” Dr. Weber explained. He noted that pre- existing neutralizing antibodies to AAV vector “is a considerable problem in the field.” There are a number of approaches that people are trying, said Dr. Weber. He stresses that multiple approaches will likely be needed and added, “I don’t know if you can ever completely solve the problem.” - Thomas Weber, PhD, Associate Professor, Medicine, Cardiology, Microbiology, Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai Learn more: https://www.genengnews.com/gen-exclusives/gene-therapy-may-not-be-a-viable-option-for- many-patients/77901045

Reader’s Digest – January 30 This Is What Really Causes An Enlarged Heart, According To A Heart Doctor — Alyssa Jung The heart is usually a tight, football-shaped muscle that pumps oxygen-rich blood throughout the entire body. But when it gets sick, it becomes enlarged, and has to work harder and harder to do its job. “The heart changes shape to become more round and spherical and bigger than its normal size,” said Sandhya K. Balaram, MD, PhD, associate professor of cardiovascular surgery at the Icahn School of Medicine at Mount Sinai. It’s also frequently a sign of congestive heart failure. “The heart muscle is failing and not working well. It’s the result of other problems in the heart causing it to become weak,” she said. Once an enlarged heart is detected, there’s treatment to relieve any symptoms and help the heart pump better, but there’s no fix. “Medical treatment doesn’t make the heart stronger, it just helps the heart work a little better,” said Dr. Balaram. “Usually it’s just controlling the symptoms and seeing how the muscle does over time. We keep up with the patient in terms of how it looks, is it getting bigger, does it look better, and then plan further treatment from there,” added Dr. Balaram. - Sandhya K. Balaram, MD, PhD, Associate Professor, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/what-causes-an-enlarged-heart/

Science & Enterprise – January 30 Microsoft Providing A.I. For Big Data Cancer Research Seven research teams are receiving grants to study complex problems in cancer immunotherapy with large-scale data sets, and assistance with machine learning and artificial intelligence provided by Microsoft Corp. The teams will divide $11 million in funds from the cancer foundation, Stand Up To Cancer, with additional financial support provided by the Lustgarten Foundation for Pancreatic Cancer Research and Society for Immunotherapy of Cancer. Microsoft is providing its expertise in machine learning, a type of artificial intelligence using algorithms that read and analyze data, then making and adjusting their inferences as new data are encountered. Benjamin Greenbaum, MD, assistant professor of medicine, hematology, medical oncology, pathology, and oncological sciences at the Icahn School of Medicine at Mount Sinai, is a leader of one of the research teams. The team will be looking at the few individuals who survive pancreatic cancer for long periods of time. The team already identified an initial set of high-quality neoantigens, or protein tags, on cancer cells that the immune system recognizes. This project will continue the team’s work to understand what makes a high-quality neoantigen and how the microbiome influences how the immune system recognizes it, with the goal of developing a method for creating vaccines to treat pancreatic cancers. - Benjamin D. Greenbaum, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://sciencebusiness.technewslit.com/?p=32530

WebMD – January 30 Memory Loss Hitting Some Fentanyl Abusers— Dennis Thompson Using fentanyl or other opioids alongside other illicit drugs could trigger possibly permanent amnesia caused by brain damage, doctors warn. Over a dozen cases have emerged in which drug abusers have developed severe short-term memory loss, possibly after experiencing an overdose. These observations are new, very unusual and quite troubling, said Timothy Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the Fellowship in Addiction Medicine Program at the Addiction Institute of Mount Sinai West. “I’ve not seen that with other opioids. I have patients who have abused heroin for years and they've never complained of that or shown any signs of that," Dr. Brennan said. "This is very unique. This is nothing I've seen before." Because fentanyl is so potent and cheaper than heroin, Dr. Brennan said, many drug traffickers have taken to cutting heroin with the synthetic. Unsuspecting buyers wind up taking a drug cocktail that's much more powerful than they expect. "As the fentanyl starts being combined with heroin, it's creating a huge increase in accidental overdoses," Dr. Brennan added. The sad part is these memory problems might doom drug users to a lifetime of addiction, since they can’t learn from their mistakes. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://www.webmd.com/mental-health/addiction/news/20180129/memory-loss-hitting- some-fentanyl-abusers?src=RSS_PUBLIC#1 Additional coverage:

TLC – January 30 I Am Jazz: Trans Girl Meets Girl Sixteen years ago, Jazz was assigned male at birth, but inside, she always knew she was a girl. Jazz has a consultation with Jess Ting, MD, surgical director of Mount Sinai’s Center for Transgender Medicine and Surgery to determine if she needs a tissue expander prior to bottom surgery. Dr. Ting determined that she does not need the tissue expander. “I think you would be a great candidate for using perineum and skin graft from the groan,” explained Dr. Ting. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.tlc.com/tv-shows/i-am-jazz/full-episodes/trans-girl-meets-girl

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