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VOLUME 276 PHARMACOLOGY JANUARY 1996 NUMBER 1 AND EXPER1MENTAL THERAPEUTICS

Contents

ANALGESIA AND DRUGS OF ABUSE

Biochemical and Pharmacological Characterization of Multiple Philip J. Monroe, Alyssa A. Hawranko, 65 3-Endorphinergic Antinociceptive Systems in the Rat Deborah L. Smith and David J. Smith Periaqueductal Gray

Autoradiographic Evidence for the Modulation of in Vivo Pascale Bouchard, Fran#{231}oisRoman, 223 Sigma Labeling by Neuropeptide Y and Calcitonin Jean-Louis Junien and R#{233}miQuirion

Gene-Related Peptide in the Mouse Brain Downloaded from

BEHAVIORAL PHARMACOLOGY

Corticotropin-Releasing Factor (CRY) Antagonist [D-Phe’2, Fernando Rodriguez de Fonseca. 56 Nle21’,C#{176}MeLeu37]CRF Attenuates the Acute Actions of the Pilar Rubio. Frdd#{233}rique Menzaghi, Highly Potent Receptor Agonist HU-210 on Emilio Merlo-Pich, Jean Rivier. jpet.aspetjournals.org Defensive-Withdrawal Behavior in Rats George F. Koob and Miguel Navarro

CARDIOVASCULAR PHARMACOLOGY Tachyphylaxis to Angiotensin II and [Phe4]-Angiotensin H in Stevan P. Tofovic and Edwin K. Jackson 13 the Rat Mesentery In Vivo

Determination of Km f1 Oxygen of Synthas#{233} Appavoo Rengasamy and Roger A. Johns 30 at ASPET Journals on October 1, 2021 Isoforms

Variable Effects of L-Arginine Analogs on L-Arginine-Nitric L. Y. Chen and J. L. Mehta 253 Oxide Pathway in Human Neutrophils and Platelets May Relate to Different Nitric Oxide Synthase Isoforms

Myocardial Protection by the Leukotriene Synthesis Inhibitor G. Rossoni, A. Sala, F. Berti, T. Testa, 335 BAY X1005; Importance of Transcellular Biosynthesis of C. Buccellati, C. Molta, Cysteinyl-Leukotrienes R. Muller-Peddinghaus, J. Maclouf and G. C. Folco

CELLULAR AND MOLECULAR PHARMACOLOGY The Unusual Binding Properties of the Endothelin Receptor Michael H. Chin, Catherine L. Cioffi, 74 Antagonist CGS 27830 Distinguishes Receptor/Agonist Michelle Garay. Robert F. Neale, Interactions Suraj S. Shetty, Dominick DelGrande, Ben Mugrage, Matthew A. Sills and Kenneth E. Lipson

A Novel P1 Purinoceptor Activates an Outward K Current in B. F. King, J. Pintor, S. Wang, 93 Follicular Oocytes of Xenopus laevis A. U. Ziganshin, L. E. Ziganshina and G. Bumstock

Tetrahydro-9-Aminoacridine has Mixed Actions on Muscarinic Peregrine B. Osborne and I 37 Currents and Blocks Currents in Rat Locus Ceruleus MacDonald J. Christie Neurons

Evidence that a Nereistoxin Metabolite, and not Nereistoxin Yu Xie, Tara McHugh, Judith McKay, 169 Itself, Reduces Neuronal Nicotinic Receptors: Studies in the Gerald S. Jones, Jr. and Ralph H. Loring Whole Chick Ciliary Ganglion, on Isolated Neurons and Immunoprecipitated Receptors

Acetylcholine-induced Chloride Current Oscillations in Swine Xibao Liu and Jerry M. Farley 178 Tracheal Smooth Muscle Cells This One

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CHEMOTHERAPY/GENE THERAPY Biological and Biochemical Anti-Human Immunodeficiency James B. McMahon, 298 Virus Activity of UC 38, a New Non-Nucleoside Reverse Robert W. Buckheit, Jr., Transcriptase Inhibitor Robert J. Gulakowski, Michael J. Currens, David T. Vistica, Robert H. Shoemaker, Sherman F. Stinson, Julie D. Russell, John P. Bader, Ven L. Narayanan, Robert J. Schultz, Walter G. Brouwer, Ethel E. Felauer and Michael R. Boyd

DEVELOPMENTAL PHARMACOLOGY Uptake of Cimetidine into Syncytial Microvillus Membrane Eric M. van der Aa, Alfons C. Wouterse, 219 Vesicles of Human Term Placenta Christel E. H. Verrijt, Jenny H. J. Copius Peereboom-Stegeman and Frans G. M. Russet Downloaded from DRUG METABOLISM AND DISPOSITION Metabolism of 3-Methylindole by Vaccinia-expressed P450 Janice Thornton-Manning, 21 Enzymes: Correlation of 3-Methyleneindolenine Formation Martin L. Appleton, Frank J. Gonzalez and and Protein-binding Garold S. Yost

Binding of Bupivacaine to Human Serum Proteins, Isolated Jean Xavier Mazoit, Lin Sen Cao and 109 Albumin and Isolated Alpha-i-Acid Glycoprotein. Differences Kamran Samii jpet.aspetjournals.org between the Two Enantiomers are Partly Due to Cooperativity

Pharmacokinetics and Blood-Brain Barrier Transport of [3H]- Dafang Wu, Ruben J. Boado and 206 Biotinylated Phosphorothioate Oligodeoxynucleotide William M. Pardridge Conjugated to a Vector-Mediated Drug Delivery System

Forskolin-Mediated Induction of CYP3A1 mRNA Expression Jaspreet S. Sidhu and Curtis J. Omiecinski 238

in Primary Rat Hepatocytes is Independent of Elevated at ASPET Journals on October 1, 2021 Intracellular cyclic AMP

Suppression of Rat Hepatic Microsomal Cytochromes P450 by James C. Kraner, Edward T. Morgan, 258 Cyclophosphamide is Correlated with Plasma Thyroid Torka S. Poet, Stephanie L. Born, Hormone Levels and Displays Differential Strain Sensitivity Vicki L. Burnett and James R. Halpert

Comparative Properties of a Technetium-99m-Labeled Single- D. J. Hnatowich, G. Mardirossian, 326 Stranded Natural DNA and a Phosphorothioate Derivative in M. Fogarasi, T. Sano, C. L. Smith,#{149} Vitro and in Mice C. R. Cantor, M. Rusckowski and P. Winnard, Jr.

ENDOCRINE PHARMACOLOGY Effect of Propionyl-L-Carnitine on Motor Nerve Conduction, Nigishi Hotta, Naoki Koh, 49 Autonomic Cardiac Function, and Nerve Blood Flow in Rats Fumihiko Sakakibara, Jiro Nakamura, with Streptozotocin-Induced Diabetes: Comparison with an Yoji Hamada, Takaaki Wakao, Aldose Reductase Inhibitor Tomohiro Hara, Koichi Mori, Keiko Naruse, Eitaro Nakashima and Nobuo Sakamoto

Beta Adrenergic Receptor Activation Attenuates the Lien Do Khac, Serge Arnaudeau, 130 Generation of Inositol Phosphates in the Pregnant Rat Nathalie Lepretre, Jean Mironneau and Myometnum. Correlation with Inhibition of Ca4 Influx, a Simone Harbon cAMP-Independent Mechanism

GASTROINTESTINAL PHARMACOLOGY The 21-Aminosteroid Tirilazad Mesylate Can Ameliorate Gang Yue, Frank F. Sun, Cohn Dunn, 265 Inflammatory Bowel Disease in Rats Kingsley Yin and Patrick Y.-K. Wong

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IMMUNOPHARMACOLOGY Novel Anti-Inflammatory Compounds Prevent CD116/CD18, Gerda Endemann, Ying Feng, 5

aMP2 (Mac-1)-Dependent Neutrophil Adhesion Without Carmen M. Bryant, Gregory S. Hamilton, Blocking Activation-Induced Changes in Mac-i John Perumattam, Richard E. Mewshaw and David Y. Liu

Cationized Hyperimmune Immunoglobuhins: William M. Pardridge, Young-Sook Kang, 246 Pharmacokinetics, Toxicity Evaluation and Treatment of Amadou Diagne and Jerome A. Zack Human Immunodeficiency Virus-Infected Human-Peripheral Blood Lymphocytes-Severe Combined Immune Deficiency Mice

The Chinese Herbal Remedy, T2, Inhibits Mitogen-Induced Xuelian Tao, Laurie S. Davis, 316 Cytokine Gene Transcription by T Cells, but Not Initial Signal Keisuke Hashimoto and Peter E. Lipsky Transduction

NEUROPHARMACOLOGY

A Dose-Response Study of Neuroprotection Using the AMPA S. H. Graham, J. Chen, J. Q. Lan and Downloaded from Antagonist NBQX in Rat Focal Cerebral Ischemia R. P. Simon

The Effects of Chomipramine on the Excitatory Action of Radmila D. Trifunovi#{233} and Mark S. Brodie 34 Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area In Vitro

Roxindole: Psychopharmacological Profile of a Dopamine D2 G. D. Bartoszyk, J. Harting and 41 jpet.aspetjournals.org Autoreceptor Agonist K.-O. Minck

YM9OK: Pharmacological Characterization As a Selective and Masao Shimizu-Sasamata, 84 Potent a-Amino-3-hydroxy-5-methyhisoxazole-4-propionate/ Sachiko Kawasaki-Yatsugi, Antagonist Masamichi Okada, Shuichi Sakamoto, Shin-Ichi Yatsugi, Junji Togami, Ken-Ichi Hatanaka, Junya Ohmori,

Kazuo Koshiya, Shinji Usuda and at ASPET Journals on October 1, 2021 Kiyoshi Murase

The Role of 5-HT3 Receptors in Periaqueductal Gray-Induced Yuan B. Peng, Qing Lin and 116 Inhibition of Nociceptive Dorsal Horn Neurons in Rats William D. Willis

Carbamazepine Inhibition of N-Methyl-D-aspartate-Evoked C. J. Hough, R. P. Irwin, X.-M. Gao, 143 Calcium Influx in Rat Cerebellar Granule Cells M. A. Rogawski and D.-M. Chuang

ABT-43i: The Diacetyl Prodrug of A-86929, a Potent and Kazumi Shiosaki, Peter Jenner, 150 Selective Dopamine D1 Receptor Agonist: In Vitro Karen E. Asin, Donald R. Bntton, Characterization and Effects in Animal Models of Parkinson’s Chun Wet Lin, Michael Michaelides, Disease Lance Smith, Bruce Bianchi, Stanley DiDomenico, Lisa Hodges, Yufeng Hong, Laura Mahan, Joe Mikusa, Thomas Miller, Arthur Nikkel, Michael Stashko, David Witte and Michael Williams

Block of the N-Methyl-D-Aspartate Receptor by Swaminathan Subramaniam, 161 and its des- Metabohite Sean D. Donevan and Michael A. Rogawski

Electrocorticographic Desynchronization After Application of Bruno Conte, Corrado Cutrufo and 212 Visceral and Somatic Noxious Stimuli in Urethane- Stefano Manzini Anesthetized Rats: Effect of Intrathecal Administration of Tachykinin (NK 1 or NK 2) Receptor Antagonists

A Catechol Derivative (4-Methylcatechol) Accelerates the Kazuko Saita, Takekazu Ohi, 231 Recovery from Experimental Acrylamide-Induced Neuropathy Yasuo Hanaoka, Shoei Furukawa, Yoshiko Furukawa, Kyozo Hayashi and Shigeru Matsukura

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Stable Expression, Pharmacologic Properties and Regulation Murali Gopalakrishnan, 289 of the Human Neuronal Nicotinic Acetylcholine aj2 Receptor Lisa M. Monteggia, David J. Anderson, Eduardo J. Molinari, Marietta Piattoni-Kaplan, Diana Donnelly-Roberts, Stephen P. Arneric and James P. Sullivan

Regulation of CREB Expression: In Vivo Evidence for a Katherine L. Widnell, David W. Self, 306 Functional Role in Action in the Nucleus Sarah B. Lane, David S. Russell, Accumbens Vidita A. Vaidya, Mindy J. D. Miserendino, Charles S. Rubin, Ronald S. Duman and Eric J. Nestler

Inhibition of N-Methyl-D-aspartate David G. Standaert, Claudia M. Testa, 342 Subunit Expression by Antisense Oligonucleotides Reveals Gregory D. Rudolf and Their Role in Striatal Motor Regulation Zane R. Hollingsworth Downloaded from PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS ‘251-APE Binding to Adenosine Receptors in Coronary Artery: Tahir Hussain, Joel Linden and 284 Photoaflinity Labeling with ‘I-azidoAPE S. Jamal Mustafa

RENAL PHARMACOLOGY jpet.aspetjournals.org Interaction of Nonpeptide Angiotensin II Receptor Antagonists Richard M. Edwards, Walt Trizna, 125 with the Urate Transporter in Rat Renal Brush-Border Elwood J. Stack and Joseph Weinstock Membranes

Effects of the Specific Angiotensin II Marguerite Hatch, Robert W. Freel, 187 Losartan on Urate Homeostasis and Intestinal Urate Transport S. Shahinfar and N. D. Vaziri

ATP Depletion by lodoacetate and Cyanide in Renal Distal Lawrence H. Lash, Jeffrey J. Tokarz, 194 at ASPET Journals on October 1, 2021 Tubular Cells Zhifeng Chen, Bonita M. Pedrosi and Edythe B. Woods

TOXICOLOGY Human Cytochrome P450 Isoform Specificity in the Wongwiwat Tassaneeyakul, 101 Regioselective Metabolism of and o-, m- and p- Donald J. Birkett, John W. Edwards, Maurice E. Veronese, Wichittra Tassaneeyakul, Robert H. Tukey and John 0. Miners

Long-Term Safety of the Aminobisphosphonate Alendronate in Chennekatu P. Peter, Jeff Guy, Marie Shea, 271 Adult Dogs. I. General Safety and Biomechanical Properties of Walter Bagdon, Walter F. Kline and Bone Wilson C. Hayes

Long-Term Safety of the Aminobisphosphonate Alendronate in Raffaella Balena, Angelo Markatos, 277 Adult Dogs. II. Histomorphometric Analysis of the L5 J. Gregory Seedor, Michael Gentile, Vertebrae Christopher Stark, C. P. Peter and Gideon A. Rodan Erratum 352