FROM GENIOUS IDEAS to HIGH TECH INNOVATIONS History Foundation: 2007: Founded by Turkish Businessmen and Scientists Who Live in Denmark and Sweden

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FROM GENIOUS IDEAS TO HIGH TECH INNOVATIONS History Foundation: 2007: Founded by Turkish businessmen and scientists who live in Denmark and Sweden. Milestones: 2007: Purchasing Nemed Tıbbi Ürünler San. ve Dış Tic. Ltd. Şti., the first and only stent and balloon manufacturer in Turkey. Since 1999 – EPHESOS Stent 30000 units per year in Turkey 2009: Purchasing In-Vivo which was manufacturing catheters to world wide known companies. - Opened in 2009, 5.500 m2 manufacturing plant in Catalca Free Trade Zone - One of the biggest Class 10.000 Clean Rooms in Europe 2011: Establishing Alvimedica Vascular Research B.V Holland only for managing R&D activities and studies. Project Partners USA Prof. Dr. Renu Virmani, CvPath International Registry of Pathology, USA Prof. Dr. Banu Onaral, Drexel University, USA Prof. Dr. Peter I. Lelkes, Drexel University, USA Zeus, USA Bard PV, USA Master Control Inc.,USA Solid Works Corp., USA Machine Solutions Inc.,USA Interface, Laguna Niguel, USA Stanford University, USA TURKEY Prof. Dr. Yıldız Özsoy, İstanbul University Prof. Dr. Aytül Erçil, Sabancı University Prof. Dr. Alpay Taralp, Sabancı University Prof. Dr. Engin Akkaya, Bilkent University Ass. Prof. Dr. Cengizhan Öztürk, Bosphorus University Ass. Prof. Dr. Sevil Dinçer, Yıldız Technical University Ass. Prof. Dr. Gamze Torun Köse, Yeditepe University TUBİTAK Marmara Research Center Project Partners GERMANY Prof. Dr. Nicolaus Reifart, Main Taunus Klinik, Germany Vascotec GmbH, Germany Suntec Medical GmbH, Germany MeKo, Germany Rofin, Germany AUSTRIA Prof. Dr. Marian Gyöngyösi, Medical University of Vienna, Austria BELGIUM Medical Device Works NV, Belgium ISRAEL STI Laser Industries, Israel The Hebrew University, Israel HOLLAND Radboud University, Holland Packcellence BV, Holland Quality Certificates Drug Eluting Stents Bare Metal Stents Balloon Catheters Balloon Catheters Angiographic & Guiding Catheters Guidew ires Stents Drug Eluting Stents CORACTO Rapamycin safety (1.7 µg/mm2) %100 bioabsorbable PLGA polymer Degrades totally in 9-12 weeks Less usage of anti-platelet therapy Complete drug release upon degradation Flexible open cell design Perfect choice for bifurcation cases CORACTO As it is shown on the picture taken from the comparative study done at CvPath Institute by Prof. Dr Renu Virmani, Coracto Rapamycin eluting stent has the best reendothelialization following after bare metal stent. * PLGA Polymer degrades completely into its monomer, following the drug release, which eliminates long term antiplatet theraphy of the patient Bare Metal Stens C o b a l t C r o m i u m COMMANDER Thinner strut – 70 micron Optimum radial strength and flexibility THANK YOU.

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