DOCSLIB.ORG

Mice Lymphopoietin in Nickel-Induced Allergy in a Critical

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Mice Lymphopoietin in Nickel-Induced Allergy in a Critical A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice This information is current as Meinar Nur Ashrin, Rieko Arakaki, Akiko Yamada, of September 28, 2021. Tomoyuki Kondo, Mie Kurosawa, Yasusei Kudo, Megumi Watanabe, Tetsuo Ichikawa, Yoshio Hayashi and Naozumi Ishimaru J Immunol 2014; 192:4025-4031; Prepublished online 26 March 2014; Downloaded from doi: 10.4049/jimmunol.1300276 http://www.jimmunol.org/content/192/9/4025 Supplementary http://www.jimmunol.org/content/suppl/2014/03/26/jimmunol.130027 http://www.jimmunol.org/ Material 6.DCSupplemental References This article cites 37 articles, 7 of which you can access for free at: http://www.jimmunol.org/content/192/9/4025.full#ref-list-1 Why The JI? Submit online. by guest on September 28, 2021 • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Author Choice Freely available online through The Journal of Immunology Author Choice option Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2014 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice Meinar Nur Ashrin,*,† Rieko Arakaki,* Akiko Yamada,* Tomoyuki Kondo,* Mie Kurosawa,* Yasusei Kudo,* Megumi Watanabe,† Tetsuo Ichikawa,† Yoshio Hayashi,* and Naozumi Ishimaru* Ni is the most frequent cause of contact allergy induced by metals. However, the underlying mechanism of this induction is unknown. Our previous research demonstrates that activation of dendritic cells (DCs) through p38MAPK/MKK6 is required for Ni-induced allergy in mice. In the current study, we investigated the cellular and molecular mechanisms underlying Ni-induced allergy using a mouse model that involves injecting Ni into the ear, with or without Freund’s incomplete or complete adjuvants. Nickel had greater potential to cause allergic reactions compared with palladium and gold. Among the proteins expressed at higher levels in mice with Ni-induced allergy, we focused on thymic stromal lymphopoietin (TSLP), which is produced in abundance by keratinocytes. We Downloaded from detected increased expression of the TSLP receptor (TSLPR) in DCs from cervical lymph nodes of mice with Ni-induced allergy, suggesting that DCs in ear tissues were activated through TSLPR signaling induced by keratinocyte-derived TSLP. Furthermore, delayed-type hypersensitivity reactions in mice with Ni-induced allergy were decreased significantly by injection of a Tslp–short interfering RNA along with atelocollagen in the ear skin. These results suggest that Ni allergy may be triggered by a TSLP/TSLPR- mediated interaction between epithelial and immune cells. The Journal of Immunology, 2014, 192: 4025–4031. http://www.jimmunol.org/ e continuously encounter materials containing Au, Ag, as Langerhans cells or dendritic cells (DCs), are induced by certain Hg, Ni, Ti, Cr, and Co in our daily lives. For example, cytokines, including IL-1b and TNF-a, which are produced by W Ni-based alloys are widely used in costume jewelry epithelial cells (16–19). APCs migrate to draining lymph nodes and dental materials, and Ni frequently causes contact allergy where they present allergens or haptens to naive T cells. Subse- categorized as type IV delayed-type hypersensitivity (DTH), with quent re-exposure to the same allergen or hapten leads to a hyper- skin inflammation mediated by hapten-specific T cells (1–5). sensitivity reaction during the effector phase (19). However, the Approximately 20% of women and 6% of men are sensitized to Ni precise molecular mechanisms that mediate interactions between (6). Symptoms of Ni allergy appear in the oral mucosa and are epithelial and immune cells in Ni allergy are unknown. by guest on September 28, 2021 widely observed in the skin (7–9). We reported previously that Ni-activated dermal DCs play an Ni ions (Ni2+) released from various alloys are potent allergens important role in the development of allergic reactions through the or haptens that can trigger inflammation of the skin (10–12). Ni2+ activation of p38 MAPK in a model system in which mice are penetrates the skin and activates epithelial cells that produce cyto- exposed to Ni combined with adjuvants (20). Although Langerhans kines or chemokines following hyperreactive immune responses cells or dermal DCs play fundamental roles in the initial phase of involving the activation of APCs and T cells (13–15). APCs, such Ni allergy, the mechanisms that regulate dermal APC responses are unknown. Therefore, using this mouse model system, we *Department of Oral Molecular Pathology, Institute of Health Biosciences, The addressed this question by determining the expression levels of University of Tokushima Graduate School, Tokushima 770-8504, Japan; and genes involved in allergy. We focused on thymic stromal lym- † Department of Oral Maxillofacial Prosthodontics, Institute of Health Biosciences, phopoietin (TSLP) and its receptor (TSLPR) because their ex- The University of Tokushima Graduate School, Tokushima 770-8504, Japan pression levels were increased significantly in the ear tissues of Received for publication January 29, 2013. Accepted for publication February 25, 2014. mice with Ni-induced allergy compared with those of other genes. Moreover, we assessed whether these findings could be used to This work was supported in part by the Funding Program for Next Generation World- Leading Researchers in Japan (LS090) and Grants-in-Aid for Scientific Research devise new therapeutic strategies or diagnostic tools to address 21792077 and 23659946 from the Ministry of Education, Culture, Sports, Science metal allergies. and Technology of Japan. The sequences presented in this article have been submitted to the Gene Expression Materials and Methods Omnibus (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52466) under ac- cession number GSE52466. Mice Address correspondence and reprint requests to Dr. Naozumi Ishimaru, Department Female C57BL/6J mice (8-wk old) were purchased from CLEA Japan of Oral Molecular Pathology, Institute of Health Biosciences, The University of (Tokyo, Japan). Nf-kb12/2 mice were obtained from The Jackson Labo- Tokushima Graduate School, 3-18-15 Kuramotocho, Tokushima 770-8504, Japan. ratory. Mice were provided a standard laboratory diet and water. They were E-mail address: [email protected] maintained in specific pathogen–free conditions and a temperature- The online version of this article contains supplemental material. controlled environment under a 12-h light/dark cycle. The Animal Eth- Abbreviations used in this article: AD, atopic dermatitis; cLN, cervical lymph node; ics Board of the University of Tokushima approved all procedures. DC, dendritic cell; DTH, delayed-type hypersensitivity; siRNA, small interfering Induction of DTH using metals RNA; TSLP, thymic stromal lymphopoietin; TSLPR, TSLP receptor. m m This article is distributed under The American Association of Immunologists, Inc., To induce DTH with Ni, 125 l 1-mM NiCl2, with or without 125 l Reuse Terms and Conditions for Author Choice articles. IFA (ICN Biomedicals, Aurora, OH), was injected i.p. for initial immu- nization. Two weeks later, 10 ml 0.2 mM NiCl2, with or without 10 mlCFA Copyright Ó 2014 by The American Association of Immunologists, Inc. 0022-1767/14/$16.00 (ICN Biomedicals), was injected intradermally into the ear skin using a www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300276 4026 A ROLE FOR TSLP IN Ni ALLERGY 26-gauge needle (TERUMO, Tokyo, Japan). DTH was determined 48 h humidified air containing 5% CO2. When the cells were 80% confluent, after the second challenge by measuring changes in ear thickness using they were stimulated with 500 or 1000 nM Ni or 1 mg/ml the TLR 4 a digital caliper. To induce DTH using other metals, 125 ml 1 mM PdCl2 or agonist LPS (Sigma Aldrich) extracted from the outer membrane of AuCl3, together with 125 ml IFA, was used for the first injection, and 10 ml Escherichia coli 0111:B4 in DMEM containing 1% FCS for 24 h. For 0.2 mM PdCl2 or AuCl3, together with 10 ml CFA, was used for the second in vitro TLR4 gene knockdown, COCA cells were transfected with TLR4 injection. or control small interfering RNAs (siRNAs; 10 nM) using Lipofectamine RNAiMAX (Life Technologies). TLR4 and negative-control siRNAs Histology (siTrio; cat no. S30C-0126) were purchased from Cosmo Bio (Tokyo, Japan). 9 Ear tissues were fixed with 10% phosphate-buffered formaldehyde (pH 7.2). The sequences of three pairs of oligonucleotides were as follows: sense, 5 - GCA UAG AGG UAG UUC CUA ATT-39; antisense, 59-UUA GGA ACU Paraffin-embedded tissue sections (4 mm) were stained with H&E. ACC UCU AUG CTT-39; sense, 59-CAC AAG AGC CGG AAG GUU ATT Flow cytometric analysis -39; antisense, 59-UAA CCU UCC GGC UCU UGU GTT-39;sense,59-GAG AAGAGGCUAAGGCCUATT-39; and antisense, 59-UAG GCC UUA Mononuclear cell preparations (1 3 106 cells)
Load more

Recommended publications
  • Metal-Specific Lymphocytes: Biomarkers of Sensitivity in Man
    Metal-Specific Lymphocytes: Biomarkers of Sensitivity in Man Metal-Specific Lymphocytes: Biomarkers of Sensitivity in Man Vera Stejskal, Antero Danersund, Anders Lindvall, Romuald Hudecek, Amer Yaqob, Ulf Lindh, Wolfgang Mayer, and Wilfried Bieger Introduction During the last years there has been an increasing interest in the possibly harmful effects of dental amalgams. Silver amalgam fillings contain a least 50% inorganic mercury together with copper, tin, silver, zinc and palladium. The toxic effects of mercury, a potent mitochondrial poison (1), are well documented and have been subject to many review articles. However, since mercury and other dental metals such as gold or silver also bind strongly to proteins (figure 1), they may function as haptens and elicit allergic and autoimmune reactions. Since induction of allergic and autoimmune reactions is generally dependent on genetic haplotype, most of the research concerning immunotoxic potential of inorganic mercury was performed in animals, where inbred strains with well-defined genetics are available. There is no doubt that inorganic mercury and gold can induce autoimmunity in genetically susceptible rats or mice. However, it is unclear why experimentally induced autoimmunity in rodents is a transitional phenomenon while clinical autoimmune disease in man often persists. Human studies have been hampered by the fact that with the exception of monozygous twins, subjects with identical genetic susceptibility/resistance to metal-induced side effects are not available. One of the ways to study the possible role of metals in the pathogenesis of various degenerative diseases is the screening of exposed populations for biological markers of susceptibility. T-lymphocytes play a crucial role in the induction of all types of allergic and autoimmune reactions and are therefore obvious candidates.
    [Show full text]
  • Systemic Nickel Allergy Syndrome Jessica Perkins, DO, PGY-III Nova Southeastern University, Largo Medical Center Largo, FL
    Systemic Nickel Allergy Syndrome Jessica Perkins, DO, PGY-III Nova Southeastern University, Largo Medical Center Largo, FL Introduction Discussion Conclusion Nickel is a major allergen associated with contact and systemic Nickel hypersensitivity is the leading cause of contact dermatitis allergic dermatitis. Case reports have noted reaction to intraoral Given the findings and history, we suggest the skin and and has recently been recognized as a potentially common culprit metals, pelvic coils and other implanted nickel (4, 6). Several gastrointestinal findings could be consistent with SNAS. SNAS in systemic contact dermatitis. Dietary nickel has also been found studies have also demonstrated diet containing nickel to be a may represent an underdiagnosed entity with implications in our to be a considerable cause in chronic allergic dermatitis. Some culprit in systemic allergic contact dermatitis (1, 3). More recently, chronic systemic contact dermatitis patients. The diet could authors also recognize systemic nickel allergy syndrome(SNAS) if a syndrome entitled, systemic nickel allergy syndrome, has been represent an exacerbating factor in these patients once sensitized to associated with extra-cutaneous symptoms ranging from described. This Syndrome is defined by systemic reactions to nickel. Foods to avoid are listed in the chart above(7). gastrointestinal to respiratory or even neurologic findings. nickel, most commonly skin and gastrointestinal. Patients with Consideration should be given to SNAS in patients with systemic Furthermore, there are case reports of hypersensitivity to this entity have positive patch testing reactions to nickel. Skin allergic contact dermatitis, GI findings and positive patch testing to exogenous nickel used in implants, prosthesis and other surgical manifestations include a diffuse eczematous dermatitis consistent Nickel.
    [Show full text]
  • Lymphocyte Transformation Test with Nickel in Hard Metal Asthma: Another Sensitizing Component of Hard Metal
    Industrial Health, 1991, 29, 153-160 153 Lymphocyte Transformation Test with Nickel in Hard Metal Asthma: Another Sensitizing Component of Hard Metal Yukinori KUSAKA*1), Yumiko NAKANO2), Taro SHIRAKAWA3), Naoki FUJIMURA4), Mikio KATO4) and Shinichiro HEKI4) 1) Department of Environmental Health, Jichi Medical School, Minamikawachi-machi, Tochigi-ken 329-04, Japan, 2) Division of Industrial Health, Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka 537, Japan 3) Department of Hygiene and Preventive Medicine, School of Medicine, Osaka University, Suita City 565, Japan 4) Department of Respiratory Diseases, Takatsuki Red Cross Hospital, Takatsuki City 569, Japan (Received June 28, 1991 and in revised form September 11, 1991) Abstract : To determine cell-mediated immunity to nickel, another matrix in hard metal besides cobalt, lymphocyte transformation tests (LTT) with nickel were carried out in seven hard metal asthma patients all of who had reacted to cobalt chloride in the bronchial provocation tests (BPT). Immunoallergic studies prior to the present study revealed that threee of the seven generated a simultaneous positive reaction in the BPT with nickel and the allergosorbent test with nickel-conjugated human serum albumin (Ni-HSA). A stimula- tion index in LTT indicating a positive response was defined on the basis of results from the studies in the controls. Data revealed that two of the three who showed a combination of positive bronchial and immunological reactions with nickel had a positive LTT with nickel. In the other five, peripheral lymphocytes did not proliferate in response to nickel. Thus it is suggested that cell-mediated immunity to nickel as well as cobalt is implicated in some cases associated with hard metal asthma.
    [Show full text]
  • Contact Allergy to Nickel: Still #1 After All These Years
    FINAL INTERPRETATION Contact Allergy to Nickel: Still #1 After All These Years John Moon, MS; Margo Reeder, MD; Amber Reck Atwater, MD Here, we review the epidemiology of nickel allergy, regu- PRACTICE POINTS lation of nickel in the United States and Europe, common • Nickel is the most common cause of contact allergy clinical presentations, and pearls on avoidance. worldwide. It is ubiquitous in our daily environment, copy making avoidance challenging. Epidemiology • Nickel allergic contact dermatitis typically presents in Nickel continues to be the most common cause of con- a localized distribution but also can present as sys- tact allergy worldwide. Data from the 2015-2016 North temic contact dermatitis. American Contact Dermatitis Group patch test cycle • Nickel regulation has been adopted in Europe, but (N=5597) showed nickel sulfate to be positive in 17.5% similar legislation does not exist in the United States. not 2 of patients patch tested to nickel. The prevalence of nickel allergy has been relatively stable in North America since 2005 (Figure 1). Although Ni-ACD historically was identified as an occupational disease of the hands in male Nickel is ubiquitous in our daily environment and remains theDo most nickel platers, the epidemiology of nickel allergy has common cause of contact allergy worldwide. Regulation of nickel shifted.1 Today, most cases are nonoccupational and affect release exists in Europe but unfortunately continues to be absent 3 in the United States. Nickel contact allergy most often is associ- women more often than men, in part due to improved ated with earrings and other jewelry; however, novel exposures to industrial hygiene, pervasive incorporation of nickel in nickel through diet and electronic devices and other materials also consumer items, and differences in cultural practices occur.
    [Show full text]
  • T Lymphocyte Phenotype of Contact Allergic Patients: Experience With
    Received: 17 December 2018 Revised: 11 February 2019 Accepted: 14 February 2019 DOI: 10.1111/cod.13246 ORIGINAL ARTICLE T lymphocyte phenotype of contact-allergic patients: experience with nickel and p-phenylenediamine Kate Wicks1 | Clare Stretton1 | Amy Popple1 | Lorna Beresford1 | Jason Williams2 | Gavin Maxwell3 | John Paul Gosling4 | Ian Kimber1 | Rebecca J. Dearman1 1Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK Background: There is considerable interest in understanding the immunological variables that 2Contact Dermatitis Investigation Unit, Salford have the greatest influence on the effectiveness of sensitization by contact allergens, particu- Royal NHS Foundation Trust, Salford, UK larly in the context of developing new paradigms for risk assessment of novel compounds. 3Unilever Safety and Environmental Assurance Objectives: To examine the relationship between patch test score for three different contact Centre, Colworth Science Park, Sharnbrook, UK allergens and the characteristics of T cell responses. 4 School of Mathematics, University of Leeds, Methods: A total of 192 patients with confirmed nickel, p-phenylenediamine (PPD) or Leeds, UK methylisothiazolinone (MI) allergy were recruited from the Contact Dermatitis Investigation Unit Correspondence at Salford Royal Hospital. Severity of allergy was scored by the use of patch testing, peripheral Dr Kate Wicks, University of Manchester, blood lymphocytes were characterized for T cell phenotype by flow cytometry, and proliferative Faculty of Biology,
    [Show full text]
  • Annotated Bibliography of Research Related to Systemic Nickel Allergy Syndrome (SNAS) Joanne Treurniet Rebelytics R&D Inc
    Annotated Bibliography of Research Related to Systemic Nickel Allergy Syndrome (SNAS) Joanne Treurniet Rebelytics R&D Inc. 7 September 2019 In this SNAS bibliography, my annotations highlight what I found relevant. I encourage you to read the original works and form your own interpretations. If a reference says “Abstract only”, it means I could not find an open source version of the full text (which also means I may be missing relevant details in my interpretation). 1. SNAS and Nickel SCD Review Articles Ahlström, M.G. et al., 2019. Nickel allergy and allergic contact dermatitis: a clinical review of immunology, epidemiology, exposure and treatment. Contact Dermatitis, 1 -15. Available at https://onlinelibrary.wiley.com/doi/full/10.1111/cod.13327 - A very good review of nickel allergy that includes both systemic and contact forms, but only discusses dermatitis as a symptom. Bergman, D. et al., 2016. Low nickel diet: A patient-centered review. Journal of Clinical and Experimental Dermatology Research, 7(355), p.2. Available at https://www.longdom.org/open-access/low-nickel-diet-a-patientcentered-review-2155-9554-1000355.pdf - Review article, defines SNAS, SCD and ACD, describes a low nickel diet, reviews the literature regarding underlying immunology and hyposensitization treatment. Goldenberg, A. and Jacob, S.E., 2015. Update on systemic nickel allergy syndrome and diet. European Annals of Allergy and Clinical Immunology, 47(1), pp.25-26. Available at http://www.eurannallergyimm.com/cont/journals-articles/352/volume-update-systemic-nickel-allergy-syndrome- 938allasp1.pdf - Letter to the editor regarding Pizzutelli’s 2011 paper, disputing its claim that SNAS is “controversial”.
    [Show full text]
  • Increased Frequency of Delayed Type Hypersensitivity to Metals In
    Journal of Trace Elements in Medicine and Biology 31 (2015) 230–236 Contents lists available at ScienceDirect Journal of Trace Elements in Medicine and Biology jo urnal homepage: www.elsevier.com/locate/jtemb CLINICAL STUDIES Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease a,∗ b c Vera Stejskal , Tim Reynolds , Geir Bjørklund a Wenner-Gren Institute for Experimental Biology, University of Stockholm, Stockholm, Sweden b Chemical Pathology, Burton Hospitals NHS Foundation Trust, Burton upon Trent, United Kingdom c Council for Nutritional and Environmental Medicine, Mo i Rana, Norway a r t i c l e i n f o a b s t r a c t Article history: Background: Connective tissue disease (CTD) is a group of inflammatory disorders of unknown aetiology. Received 12 November 2014 Patients with CTD often report hypersensitivity to nickel. We examined the frequency of delayed type Accepted 6 January 2015 hypersensitivity (DTH) (Type IV allergy) to metals in patients with CTD. Methods: Thirty-eight patients; 9 with systemic lupus erythematosus (SLE), 16 with rheumatoid arthritis Keywords: (RA), and 13 with Sjögren’s syndrome (SS) and a control group of 43 healthy age- and sex-matched Systemic lupus erythematosus subjects were included in the study. A detailed metal exposure history was collected by questionnaire. Rheumatoid arthritis ® Metal hypersensitivity was evaluated using the optimised lymphocyte transformation test LTT-MELISA Sjögren’s syndrome (Memory Lymphocyte Immuno Stimulation Assay). Delayed type hypersensitivity Results: In all subjects, the main source of metal exposure was dental metal restorations. The majority Metal allergy of patients (87%) had a positive lymphocyte reaction to at least one metal and 63% reacted to two or more metals tested.
    [Show full text]
  • Cytokine Responses in Metal-Induced Allergic Contact Dermatitis: Relationship to in Vivo Responses and Implication for in Vitro Diagnosis
    Cytokine responses in metal-induced allergic contact dermatitis: Relationship to in vivo responses and implication for in vitro diagnosis Jacob Taku Minang Stockholm, 2005 Doctoral Thesis from the Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden Cytokine responses in metal-induced allergic contact dermatitis: Relationship to in vivo responses and implication for in vitro diagnosis Jacob Taku Minang Stockholm, 2005 ISBN 91-7155-158-1 pp 1-79 © Jacob Taku Minang PrintCenter, Stockholm University 2005 Stockholm 2005 “Without love, benevolence becomes egotism” -Dr. Martin Lurther King Jr. (1929-1968) “People like you and I, though mortal of course like everyone else, do not grow old no matter how long we live…[We] never cease to stand like curious children before the great mystery into which we were born.” - Albert Einstein (1879-1955): in a letter to Otto Juliusburger (1867-1952). To my dear mum, Minang Margaret Atih ORIGINAL PAPERS This thesis is based on the following original papers, which are referred to in the text by their Roman numerals. Paper I. Jacob T. Minang, Marita Troye-Blomberg, Lena Lundeberg and Niklas Ahlborg (2005). Nickel elicits concomitant and correlated in vitro production of Th1-, Th2-type and regulatory cytokines in subjects with contact allergy to nickel. Scand J Immunol. 62:289-296. Paper II. Jacob T. Minang, Iréne Areström, Bartek Zuber, Gun Jönsson, Marita Troye-Blomberg, Niklas Ahlborg (2005). Regulatory effects of IL-10 on Th1- and Th2-type cytokines induced in response to the contact allergen nickel. Submitted. Paper III. Jacob T. Minang, Iréne Areström, Marita Troye-Blomberg, Lena Lundeberg, Niklas Ahlborg (2005).
    [Show full text]
  • Two Cents About Nickel
    Two Cents about Nickel Only wear nickel-free jewelry, including earrings, necklaces and watches. Keep a barrier, such as an undershirt, between your skin and metal snaps and zippers on clothing. If you are having your ears pierced, choosing the right pair of earrings can prevent nickel allergy from developing. Wear only stainless steel or solid gold earrings until the piercing has completely healed—about three weeks. While most reactions are uncomfortable and unat- tractive, they are usually easily treated. Your aller- gist/immunologist can recommend the best treat- ment for an allergic reaction. If the rash is small, a doctor may prescribe medi- cated creams (topical corticosteroids) to rub on Nickel is a leading cause of allergic contact derma- the irritated skin. For larger or more serious out- titis––an itchy rash that develops when a person’s breaks, pills may be required. skin touches a normally harmless material. Talk to your allergist/immunologist if you think you Nickel is a silver-colored metal that is mixed with have a nickel allergy. An allergist/immunologist is other metals to make coins, jewelry, eyeglass the best doctor to diagnose nickel allergy and pre- frames, home fi xtures, keys and other common scribe treatments. items. In people allergic to it, nickel causes an itchy red rash, similar to a reaction from poison ivy. More women than men are allergic to nickel. This is probably because women are more likely to have To the Point pierced ears. Studies show that body piercing is the Nickel can be found in braces, crowns and single most common cause of nickel allergy.
    [Show full text]
  • Diffuse Nickel Hypersensitivity Reaction Post- Cholecystectomy in a Young Female
    Open Access Case Report DOI: 10.7759/cureus.17146 Diffuse Nickel Hypersensitivity Reaction Post- cholecystectomy in a Young Female Enkhmaa Luvsannyam 1, 2 , Arathi Jayaraman 3 , Molly S. Jain 4 , Ravi P. Jagani 5 , Veronica Velez 4 , Anushka S. Mirji 6 , Frederick Tiesenga 7 , Juaquito Jorge 8 1. Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 2. Surgery, Avalon University School of Medicine, Youngstown, USA 3. Medicine, Xavier University School of Medicine, Oranjestad, ABW 4. Medicine, Saint James School of Medicine, Park Ridge, USA 5. Medicine, All Saints University College of Medicine, Kingstown, VCT 6. Surgery, Metropolitan University College of Medicine, St. John's, ATG 7. General Surgery, West Suburban Medical Center, Chicago, USA 8. General and Vascular Surgery, West Suburban Hospital, Oak Park, USA Corresponding author: Enkhmaa Luvsannyam, [email protected] Abstract Nickel, a silvery-hard metallic element used in corrosion-resistant alloys, is widely used in the medical field. Nickel has aided in medical advancements; however, it has been known to cause hypersensitivity reactions. Retained foreign bodies due to surgical procedures may cause postoperative complications such as allergic reactions. This case involves a 30-year-old female presenting with non-specific symptoms involving multiple organ systems, notably with abdominal pain. Due to chronic symptoms, the patient was tested for metal allergies and diagnosed with hypersensitivity reactions to nickel surgical clips that were previously inserted during cholecystectomy. Subsequently, the patient had surgical removal of the foreign bodies, which led to significant improvement of her symptoms immediately. This case demonstrates a delayed hypersensitivity reaction to a foreign body involving multiple body systems and vague symptoms making the diagnosis challenging.
    [Show full text]
  • Nickel-Induced Contact Dermatitis Peripheral and Cutaneous T Cells
    Preferential Usage of TCR-Vβ17 by Peripheral and Cutaneous T Cells in Nickel-Induced Contact Dermatitis This information is current as Lioba Büdinger, Nicole Neuser, Uwe Totzke, Hans F. Merk of September 27, 2021. and Michael Hertl J Immunol 2001; 167:6038-6044; ; doi: 10.4049/jimmunol.167.10.6038 http://www.jimmunol.org/content/167/10/6038 Downloaded from References This article cites 30 articles, 8 of which you can access for free at: http://www.jimmunol.org/content/167/10/6038.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 27, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2001 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Preferential Usage of TCR-V␤17 by Peripheral and Cutaneous T Cells in Nickel-Induced Contact Dermatitis1 Lioba Bu¨dinger,*† Nicole Neuser,* Uwe Totzke,‡ Hans F. Merk,* and Michael Hertl2*§ Nickel (Ni) is one of the most common contact sensitizers in man, and Ni-induced contact dermatitis is considered as a model of hapten-induced delayed type hypersensitivity.
    [Show full text]
  • Nickel Allergy Is Found in a Majority of Women with Chronic Fatigue Syndrome and Muscle Pain– and May Be Triggered by Cigarette Smoke and Dietary Nickel Intake
    Nickel Allergy Is Found in a Majority of Women with Chronic Fatigue Syndrome and Muscle Pain– And May Be Triggered by Cigarette Smoke and Dietary Nickel Intake Björn Regland, MD Olof Zachrisson, MD Vera Stejskal, PhD Carl-Gerhard Gottfries, MD ABSTRACT. Two hundred and four women with chronic fatigue and muscle pain, with no signs of autoimmune disorder, received immune stimulation injections with a Staphylococcus vaccine at monthly inter- vals over 6 months. Good response was defined as a decrease by at least 50% of the total score on an observer’s rating scale. Nickel allergy was evaluated as probable if the patient had a positive history of skin hyper- sensitivity from cutaneous exposure to metal objects. The patient’s smoking habits were recorded. Fifty-two percent of the patients had a Björn Regland is Assistant Professor, Olof Zachrisson is Medical Doctor, and Carl-Gerhard Gottfries is Professor, all affiliated with the Department of Psychiatry, Sahlgrenska University Hospital/Mölndal and Institute of Clinical Neuroscience, Göteborg, Sweden. Vera Stejskal is Assistant Professor, Department of Clinical Chemistry, Danderyd Hospital and Karolinska Institute, Stockholm. Address correspondence to: Björn Regland, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, SE-431 80 Mölndal, Sweden (E-mail: bjorn.regland @ms.se). The authors express their thanks to Swiss Serum & Vaccine Institute Berne for providing them with the Staphylococcus vaccine, and to Veronica Nordman for the performance of in vitro testing. Journal of Chronic Fatigue Syndrome, Vol. 8(1) 2001 E 2001 by The Haworth Press, Inc. All rights reserved. 57 58 JOURNAL OF CHRONIC FATIGUE SYNDROME positive history of nickel contact dermatitis.
    [Show full text]