Anti-CMPK2 (C-terminal) polyclonal antibody (DPABH-02072) This is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.

Immunogen Synthetic peptide corresponding to 19 amino acid residues near the carboxy terminus of Human CMPK2 (NP_997198).

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, ICC/IF

Format Liquid

Size 100 μl

Buffer Constituent: 99% PBS

Preservative 0.02% Sodium Azide

Storage Store at 4°C or -20°C long term. Avoid repeated freeze / thaw cycles. Store undiluted.

GENE INFORMATION

Gene Name CMPK2 cytidine monophosphate (UMP-CMP) 2, mitochondrial [ Homo sapiens ]

Official Symbol CMPK2

Synonyms CMPK2; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; UMP-CMP kinase 2,

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved mitochondrial; cytidylate kinase 2; TYKi; UMP CMPK2; mitochondrial UMP-CMP kinase; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member; TMPK2; UMP-CMPK2;

Entrez Gene ID 129607

Protein Refseq NP_001243406

UniProt ID Q5EBM0

Chromosome Location 2p25.2

Pathway Metabolic pathways; Pyrimidine metabolism; Pyrimidine ribonucleotide biosynthesis, UMP =>UDP/UTP,CDP/CTP;

Function ATP binding; UMP kinase activity; cytidylate kinase activity; kinase activity; nucleotide binding; thymidylate kinase activity; activity

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved