The Journal of Clinical Pharmacology

Activity Report Issues 47: 1 – 3 January – March 2007

Contents

Circulation...... 3 Commercial Sales ...... 5

Summary ...... 5 Commercial Reprints ...... 6 Supplements ...... 7 Journal Activity Summary ...... 7

Production...... 7 Abstracting & Indexing ...... 8 Thomson Scientific JCR® Ranking and Impact Factor...... 9 JCP Online...... 10 Marketing ...... 16

Strategy...... 16 Direct Mail and Email Summary...... 16 Quarterly Promotional Summary ...... 17 Conferences...... 17 Assisting with ACCP Membership Growth ...... 18 Institutional Marketing...... 18 JCP Email Alerts...... 18 Appendix: JCP’s Publishing Team at SAGE ...... 20

– 2 – © SAGE Publications Confidential to the ACCP and SAGE Publications Circulation

Expanding Institutional Access via Consortial Sales & Developing World Initiatives The ways in which libraries are purchasing journals has changed. Many libraries still purchase individual titles directly from the publisher or their subscription agent; we consider this a “traditional” institutional subscription. In recent years, however, more and more libraries have joined together into buying groups, called consortia, through which they negotiate with publishers to buy packages of journals. SAGE’s sales team sells to individual libraries and to consortia. In just the last year, we negotiated a number of major consortia deals in which JCP is included. This now means that many more institutions, both domestic and international, have access to JCP, as detailed in the circulation table below. It also means that some “traditional” library subscriptions have migrated from to a consortial subscription, while maintaining access to JCP throughout.

This table shows the circulation for JCP issue by issue from 2006 through the first three issues of 2007. As of this report, 1,240 institutions have access to JCP; in the next quarter, we will have more consortia libraries to report, as our sales team recently closed several large deals that will significantly expand institutional access to JCP. Please note that since we are still in the renewal season, these numbers are not considered final.

JCP Circulation by Issue 2006 46/1 46/2 46/3 46/4 46/5 46/6 46/7 46/8 46/9 46/10 46/11 46/12 Individuals 34 32 31 31 32 32 42 38 38 39 37 36 Members 826 827 830 852 844 843 758 760 778 779 839 837 Institutions 1,352 1,341 1,333 1,332 1,333 1,332 1,347 1,339 1,336 1,306 1,306 1,306

Traditional1 – Print & Online 352 351 345 344 344 342 350 347 343 350 350 350

Traditional1 – Online Only 128 128 129 130 131 131 133 133 134 139 139 139

Traditional1 – Print Only 291 280 278 277 277 278 283 278 278 279 279 279 Institutions – Consortia2 581 581 581 581 581 581 581 581 581 5384 5384 5384

Total Subscribers 2,212 2,200 2,194 2,215 2,209 2,207 2,147 2,137 2,152 2,094 2,182 2,179 2007

47/1 47/2 47/3 47/4 47/5 47/6 47/7 47/8 47/8 47/10 47/11 47/12 Individuals 16 16 18 ------Members 836 838 837 ------Institutions 1,368 1,309 1,240 ------Traditional1 – Print & Online 397 353 2673 ------Traditional1 – Online Only 106 137 156 ------

Traditional1 – Print Only 327 281 278 ------Institutions – Consortia2 5354 5354 5354,5 ------Total Subscribers 2,220 2,163 2,095 ------1Libraries purchasing JCP directly from SAGE. This is a combination of print only, e-access, and combined subscriptions. 2There may be a few traditional subscribers in this number, e.g., libraries which have migrated to a consortial arrangement but have not yet cancelled their original direct subscription. 3This number is estimated to be slightly understated, as the renewal season is still in progress during this period of time. 4In this quarter we saw an adjustment in the number of libraries with access to JCP through consortia. This sort of change happens when consortia allow libraries to drop out of their arrangements at various times in the year

– 3 – © SAGE Publications Confidential to the ACCP and SAGE Publications SAGE Premier Another way that JCP content is available to consortia is through the SAGE Premier package of journals, which includes the entire SAGE portfolio of 452 titles. Sales of SAGE Premier are negotiated on a case-by-case basis by our sales team, and they are typically arrived at by determining how much a given consortium pays SAGE for all the SAGE journals to which it currently subscribes. We then charge the consortium an additional fee (known as the incremental consortia revenue) to allow each member institution to gain access to all of our journals. The advantages of this sort of deal are that all SAGE content is more widely disseminated and, hence, used; additional 'new' revenue is gained by SAGE and the participating titles; the consortium is less able to cancel its primary subscriptions; and the consortium is able to better predict what its future spending will be with SAGE.

In a SAGE Premier sale, every journal which was part of the original holdings of the consortium will receive its full subscription revenue (i.e. it will experience no reduction in revenue by being part of the deal) and a share of the incremental consortia revenue. As for the incremental revenue, this amount is distributed among all 452 titles that currently comprise the deal regardless of whether or not they were originally subscribed to. The revenue is shared according to a weighting formula, which takes into account the subscription price of each journal and the number of subscriptions it has in total.

By these allocations, all journals that are part of SAGE Premier will see more revenue as a result of being in a deal: journals already held by a consortium will continue to see their full revenue plus a share of the incremental revenue, and journals that were not originally held by the consortium will now receive a share of the incremental revenue. In reality, because of the number of journals involved, the incremental revenue is not a large sum for any single journal, so the main benefit should be viewed as the increased exposure and usage that a participating journal will receive and the decreased likelihood of cancellations going forward.

This table lists the consortia that can currently access JCP through the SAGE Premier package of journals.

Consortia Purchasing JCP - SAGE Premier Consortium Acronym Consortium Name HEAL-LINK Hellenic Academic Libraries (Greece) ANKOS Turkish Consortium BIBSAM National Libraries of Sweden CBUC Consortia de Biblioteque Universitaries de Catalunya (SPAIN) CILEA Italian Consortium EIFL Slovenian Consortium FINELIB Finnish Consortium Couperin French Consortium Niedersachen German Consortium OPEN Spanish Consortium UKB National Libraries of the Netherlands CSIC Consejo Superior de Investigaciones Científicas HeBIS German Consortium

– 4 – © SAGE Publications Confidential to the ACCP and SAGE Publications Consortia Purchasing JCP - SAGE Premier IREL Ireland Consortium NEICON Russian Consortium SASLI South African Consortium

Geographical Distribution The chart below shows the geographic distribution of traditional and consortial library subscribers as of March 2007.

Institutional Circulation (Traditional and Consortial)

Asia Australasia 11% 1% Europe South 23% America 10% Africa 1% Middle East 1%

North America (US, Canada, Mexico) 53%

Commercial Sales Summary This table summarizes JCP’s commercial sales revenue in 2006 and compares the first quarter of 2006 with that of 2007.

JCP Commercial Sales Summary

2006 2006 2007

Year-End Quarter 1 Quarter 1

Advertising $3,548 $0 $0

Supplements $7,150 $0 $0

Commercial $890,449 $110,907 $193,364 Reprints

Author Reprints $7,579 $326 $0

Total $908,726 $111,233 $193,364

– 5 – © SAGE Publications Confidential to the ACCP and SAGE Publications Commercial Reprints We are pleased with the commercial reprints results from the first quarter of 2007, which are up 75 percent over the first quarter of 2006. However, we do realize that the balance of the year needs to be very strong in order to surpass 2006 year-end totals.

The breakdown of the first quarter reprint orders by year the articles were originally published: • Current year (2007) – 10% • Previous year (2006) – 40% • 2 years old and older (2005 and earlier) – 50%

We are monitoring the above trends to determine how historical content contributes to current reprint activity.

We continue to review upcoming and recent Tables of Contents for articles with reprint potential and contact appropriate product managers or past reprint customers regarding these articles. In addition, we continue to consult with Dr. Von Moltke on the reprint potential of each upcoming issue.

The following graph shows the trend in commercial reprint sales from 1999 through the first quarter of 2007.

JCP - Annual Reprint Sales (Commercial & Author Reprints)

$2,000,000

$1,500,000

$1,000,000

$500,000

$0 1999 2000 2001 2002 2003 2004 2005 2006 2007 YTD

REVENUE $415,000 $649,000 $1,652,68 $634,186 $641,015 $450,735 $622,876 $898,028 $193,364

The following is a list of all commercial reprint orders from the first quarter of 2007.

Commercial Reprint Orders, January - March 2007 Date Customer Author Volume Issue Quantity Revenue 1/16/07 Content Ed Net Shah 46 10 1,000 $2,957.00 Bartlett Davis 1/16/07 Communications Serra 45 9 2,000 $5,671.00 1/18/07 A. Menarini Bagan 38 12S 3,000 $7,604.00 1/22/07 Knowledgewire Kovarik 42 2 500 $2,281.00 2/1/07 Adis Int'l - Japan Kovarik 42 2 1,000 $2,957.00 2/2/07 Reprints Desk Chen 45 8 300 $3,198.00 2/27/07 Nycomed Marier 46 6 5,000 $13,889.00 3/5/07 Content Ed Net Shah 46 10 $832.00 – 6 – © SAGE Publications Confidential to the ACCP and SAGE Publications Commercial Reprint Orders, January - March 2007 Date Customer Author Volume Issue Quantity Revenue 3/6/07 Merck & Co. Dallob 43 6 2,000 $7,036.00 3/9/07 Content' Ed Net Sullivan 46 6 1,000 $3,784.00 ProMedica Clinical Research 3/14/07 Center, Inc. Farkas 47 3 100 $1,540.00 Novartis Pharma 3/15/07 AG Chen 42 11 500 $2,654.00 3/19/07 Pom Wonderful Farkas 47 3 500 $2,654.00 3/22/07 UCB, Inc. Browne 40 6 10,000 $13,378.00 Wolters Kluwer 3/22/07 Health Morganroth 42 5 700 $3,227.00 Medical Reprint 3/30/07 Services Damle 46 11 10,000 $21,934.00 3/30/07 Content Ed Net Sullivan 46 6 3,000 $6,811.00 MDS Pharma 3/30/07 Services Dockens 46 11 100 $1,400.00 Janssen-Cilag 3/30/07 SPA Marier 46 6 5,000 $17,177.00 3/30/07 Merck & Co. Dallob 43 6 50,000 $72,380.00 Total $193,364.00

Supplements We do not currently have any supplements in the pipeline, but encourage the ACCP and the Editorial Board to forward any leads to Bob Vrooman, our Commercial Sales Director. Journal Activity Summary

Production Editorial Page Budget The annual page budget for each volume of JCP is a maximum of 1,440 editorial pages, or an average of 120 pages per issue. As the table below shows, the journal is averaging approximately 132 editorial pages per issue for Volume 47, which currently projects over budget.

JCP Page Usage versus Budget, Volumes 44 – 47 1 2 3 4 5 6 7 8 9 10 11 12 Total YTD % of YTD Annual Volume Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec YTD Budget Budget Budget Vol 44 2004 107 100 112 120 112 119 146 123 132 140 118 108 1437 1440 100% 1440 Vol 45 2005 118 120 124 119 121 126 122 116 122 109 113 134 1444 1440 100% 1440 Vol 46 2006 121 125 133 101 100 115 133 115 137 125 155 136 1496 1440 103.8% 1440 Vol 47 2007 138 138 129 129 124 ------658 600 109.6% 1440

SAGE OnlineFirst SAGE OnlineFirst is a new feature offered on JCP’s homepage through SAGE Journals Online (SJO), http://jcp.sagepub.com. It allows final revision articles (completed articles in queue for assignment to an upcoming issue) to be hosted online prior to their inclusion in a final JCP print and online issue. This feature is commonly referred to as “publish ahead of print,” “publish before print,” “continuous publishing,” and “P>P.”

– 7 – © SAGE Publications Confidential to the ACCP and SAGE Publications SAGE OnlineFirst provides clear benefits to all researchers and users of JCP’s online content. The feature allows subscribers and members the ability to access the very latest papers in the field. Authors also benefit from greatly reduced lead times between submission and publication of articles. Without OnlineFirst, an author's work would only appear online once a “finalized” JCP issue was sent to press. However, with OnlineFirst, JCP manuscripts can appear online while other articles are being completed for an upcoming issue. An author’s research will therefore reach its audience more quickly, enabling an article to receive greater usage and exposure, including earlier citation opportunities by related work.

Each OnlineFirst JCP manuscript is citable, the official publication date being the date of the manuscript's first online posting. In place of page numbers, which are assigned along with the final issue, OnlineFirst papers are assigned DOIs (Digital Object Identifiers), from the DOI Foundation (http://www.doi.org/). DOIs provide a persistent, permanent way to identify manuscripts published in the online environment, even after they are assigned to a print issue and given an actual volume, issue, and first page number. Each article DOI is registered with CrossRef (http://www.crossref.org/), allowing permanent resolution to each article and giving publishers the ability to link their references to JCP articles whenever they are cited.

Once a JCP OnlineFirst article is assigned to its final issue and given its bibliographic data, such as volume, issue, and first page number, the hosting of the article online transitions from the OnlineFirst listing to that of the completed issue. In other words, users will be able to locate the article via JCP’s main archive page or the current issue link rather than the OnlineFirst page. Citations using either the DOI or the bibliographic data will both resolve to the final article. The P>P version of the article will remain available but as a version to the final article. The primary, completed article will be the prominent article found when linking into the DOI or article URL.

Please visit http://jcp.sagepub.com to view all JCP OnlineFirst article postings. Readers and authors alike are encouraged to sign up for JCP’s OnlineFirst email alert option, ensuring immediate notification each time a paper is published online first. Email alerts are also available for ongoing JCP tables of contents and for alerts by author name and keyword. Visit http://jcp.sagepub.com/cgi/alerts to register.

Abstracting & Indexing Abstracting and indexing activity is key to creating researcher awareness and attracting contributions. JCP has excellent coverage among the primary indexing services, including MEDLINE, Ovid, and Thomson Scientific Journal Citation Reports®. The comprehensive list given below is also available online at http://.jcp.sagepub.com (click on “Abstracting and Indexing”), where it is updated regularly.

• Biological Abstracts • Current Contents: Life Sciences • Biosciences Citation Index • EMBASE/Excerpta Medica • BIOSIS Previews • Global Health • CAB Abstracts Database • InfoTrac (full text) • Chemical Abstracts • International Pharmaceutical Abstracts • ChemSciences Citation Index • MEDLINE • CINAHL database and CUMULATIVE • Ovid (full text) INDEX TO NURSING AND ALLIED • Science Citation Index

– 8 – © SAGE Publications Confidential to the ACCP and SAGE Publications HEALTH LITERATURE • Science Citation Index Expanded (Web of • Clinical Medicine Citation Index Science) • Current Contents: Clinical Medicine • Scopus

Thomson Scientific JCR® Ranking and Impact Factor The Journal Citation Reports® (JCR), published by Thomson Scientific (formerly ISI), is a comprehensive and unique resource for journal evaluation, using citation data drawn from 7,500 scholarly and technical journals worldwide. Coverage is both multidisciplinary and international, incorporating journals from over 3,300 publishers in 60 nations. To be included among the journals in the JCR is indeed a great accomplishment, as only the top 10–12 percent of all scholarly journals is included.

A journal’s impact factor is a measure of the frequency with which the “average article” in the journal has been cited in a particular year. The impact factor is calculated by dividing the number of current citations to articles published in the two previous years by the total number of articles published in the two previous years. Impact factors of a number of journals in the same discipline can be compared and ranked.

With an impact factor of 2.889, JCP, ranked 50/193, is in the top 30% of the Pharmacology and Pharmacy category.

JCP Impact Factor and Ranking Impact Pharmacology Year Factor and Pharmacy 2005 2.889 50/193 2004 2.273 64/187 2003 1.945 76/185 2002 1.960 64/188 2001 2.167 49/186

JCP Impact Fact or Trend

3.5

3 JCP Impact Fact or Trend 2.5

1. 5

0.5

0 2001 2002 2003 2004 2005

– 9 – © SAGE Publications Confidential to the ACCP and SAGE Publications We expect that increased exposure on SAGE Journals Online will help to increase JCP’s impact factor and ranking over time by increasing citations. A number of other strategies can be employed, including:

• Timeliness. Maintain on-time publication; publishing on time implies a healthy backlog of manuscripts essential for ongoing viability. • International diversity. Increase the number of international authors and Editorial Board members to reflect a global approach and coverage—Thomson Scientific looks for journals that will meet the needs of its international subscriber base. • Articles on emerging topics. Publish on emerging topics to help differentiate JCP from its competition—Thomson Scientific looks for content that will enrich their databases. • Review articles. According to Thomson Scientific, “Review articles generally are cited more frequently than typical research articles because they often serve as surrogates for earlier literature, especially in journals that discourage extensive bibliographies.” (Thomson Scientific, “The ISI Impact Factor,” http://scientific.thomson.com/free/essays/journalcitationreports/impactfactor/ ). • Selection of widely-cited authors. Publish articles written by authors who have contributed to other journals ranked in the JCR—they are likely to cite their previous work to support their current article, which will potentially increase the citation count for your journal.

Thomson Scientific publishes the JCR annually in late June or early July, and we will be sure to provide you with an updated report when it becomes available.

JCP Online Online usage, along with traditional subscriber growth and retention, is an important indicator of a journal’s success. Librarians monitor how often a journal is accessed and use this information when they make their renewal and cancellation decisions. Journal editors can also use online usage statistics to review citations, up-and-coming topics in the field, and declining subject areas. In order to increase awareness of JCP and to retain institutional subscriptions, many of our marketing efforts are focused on bringing more users to the online content. Please see our Marketing section below for detailed reports on the results of these campaigns.

Usage Statistics on SAGE Journals Online Each year, we are seeing significant increases in online usage across all of our journals. As a part of our efforts to promote online usage, we provide free-access periods to targeted markets on a regular basis. It is important to note these periods when reviewing usage data, as “hits” and downloads increase significantly during those times.

To celebrate the digitization of our journals’ backfile, we implemented a free-access period in February 2007 to all institutions subscribing to at least one SAGE journal. As you will see below, JCP’s inclusion in this trial had a positive impact on full-text article downloads.

In addition, JCP was also included in our Pharmacology and Toxicology discipline free online trial taking place in March and April 2007. We are pleased to report significant increases in JCP’s usage for March and will be able to evaluate April usage in the next report.

– 10 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications

A detailed summary of online usage activity for 2005–YTD 2007 is provided in the following table. Full-text article downloads are the best way to measure online usage, as they imply the reading of full articles, rather than abstracts. JCP has full-text availability in both HTML and PDF formats, so these two columns must be added together to get the total number of articles downloaded.

JCP Usage on SAGE Journals Online 2005 Full- Home Current All Full-Text 1 Searches Abstracts text Total Page issue TOC TOCs HTML PDFs January 6,141 1,248 7,137 4,145 36,480 21,066 4,195 80,412 February 7,077 1,380 8,208 4,577 43,696 20,868 5,907 91,713 March 8,415 1,834 5,852 6,212 44,242 22,391 9,105 98,051 April 6,538 1,500 5,257 7,037 40,197 25,435 40,148 126,112 May 8,132 1,649 5,181 5,900 52,781 31,167 11,029 115,839 June 7,606 1,738 5,531 4,937 51,037 29,543 10,033 110,425 July 7,583 1,682 6,005 5,064 48,707 28,394 12,377 109,812 August 7,290 1,656 4,083 4,789 43,068 27,782 10,194 98,862 September 6,861 1,556 4,468 4,964 34,562 23,088 15,505 91,004 October 7,639 1,577 7,794 5,751 79,392 28,060 16,105 146,318 November 9,834 1,503 4,014 5,229 51,268 27,724 11,079 110,651 December 18,661 1,346 5,105 5,030 36,295 20,956 29,648 117,041 Total 101,777 18,669 68,635 63,635 561,725 306,474 175,325 1,296,240 2006 Full- Home Current All Full-Text 1 Searches Abstracts text Total Page issue TOC TOCs HTML PDFs January 7,595 1,852 4,593 5,345 44,919 7,942 9,000 79,394 February 7,441 1,759 5,033 5,252 42,658 7,070 11,573 79,027 March 8,965 1,800 5,817 5,955 50,244 8,074 12,571 91,626 April 8,052 1,666 4,581 4,981 40,448 6,468 8,538 73,068 May 8,260 1,518 3,272 5,296 42,833 7,311 10,891 77,863 June 7,209 1,488 3,414 4,474 46,981 6,956 17,006 86,040 July 7,894 1,690 3,938 5,291 43,265 6,728 14,909 82,025 August 9,461 1,785 5,462 5,839 47,265 7,522 10,076 85,625 September 8,877 1,603 5,662 7,899 67,930 9,084 18,120 117,572 October 9,176 1,665 5,464 12,049 58,681 8,624 17,841 111,835 November 9,287 1,548 3,994 11,515 63,992 7,079 14,610 110,477 December 6,957 1,233 3,193 9,264 45,026 4,760 9,337 78,537 Total 99,174 19,607 54,423 83,160 594,242 87,618 154,472 1,073,089 2007 Full- Home Current All Full-Text 1 Searches Abstracts text Total Page issue TOC TOCs HTML PDFs January 9,499 1,751 5,099 11,318 62,858 7,721 13,716 110,211 February (free 8,547 1,488 3,634 13,569 55,214 8,233 23,051 112,248 trial) March (free trial) 10,567 1,636 4,395 17,613 52,856 28,883 64,142 178,456 April (free trial) May June – 11 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications

JCP Usage on SAGE Journals Online July August September October November December Total 18,046 3,239 8,733 24,887 118,072 15,954 36,767 222,459

1The "Current issue TOC" count is not summed into the monthly total since that count is also included in the "All TOCs" count.

NOTE: In 2006, HighWire removed all robot/crawler usage activity. Although the numbers look lower, this is a more accurate representation of overall usage.

The chart below illustrates the monthly number of combined full-text HTML and PDF Full-Text Downloads (FTDs) made since January 2004. As the chart indicates, the current Pharmacology and Toxicology free trial has dramatically increased article downloads for March. In fact, the journal received its highest number of downloads in a single month with 93,025 articles accessed. We hope this enhanced usage leads to increased citations and manuscript submissions, library recommendations, and greater overall exposure for JCP and the ACCP.

JCP Online Usage via SAGE Journals Online HTML and PDF FTDs by Month, 2004 - YTD 2007

100,000 90,000 80,000 70,000

60,000 2004 50,000 2005 40,000 2006 2007 30,000 20,000 10,000 0 Jan Feb Mar Apr May Jun Jul Aug Sept Oct Nov Dec

Most Frequently-Accessed Articles on SAGE Journals Online This table shows which articles were accessed most frequently from January 2006 through March 2007 on SAGE Journals Online (SJO). The articles are ranked by total accesses, which is the combined sum of full-text downloads and abstract views.

– 12 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications

Top 10 Most Frequently-Accessed Articles via SAGE Journals Online, January – March 2007

Full- Age of Article Total text PDF Abstracts in days from Article Accesses HTML 03/31/2007

Enrique Delamonica, John W. Shaffer, Clinton C. Brown, Albert A. Kurland Effects of Dextroamphetamine, Pentobarbital, 0 9 1,487 1,496 14,884 Chlorphentermine, and Placebo on the Alpha Blocking Response in Normal Subjects Jul 01, 1966 6: 224-228

David M. Benjamin Reducing Medication Errors and Increasing Patient Safety: 472 335 684 1,491 1,370 Case Studies in Clinical Pharmacology Jul 01, 2003 43: 768-783

H Staunstrup, J Ovesen, UT Larsen, K Elbaek, U Larsen, K Kroner Efficacy and tolerability of lornoxicam versus tramadol in 0 34 1,177 1,211 2,800 postoperative pain Aug 01, 1999 39: 834-841

RT Jones 0 420 750 1,170 1,612 Cardiovascular system effects of marijuana Nov 01, 2002 42: 58-63

Anne C. Hermann, Anne N. Nafziger, Jennifer Victory, Robert Kulawy, Mario L. Rocci, Joseph S. Bertino Over-the-Counter Progesterone Cream Produces Significant 263 57 816 1,136 669 Drug Exposure Compared to a Food and Drug Administration- Approved Oral Progesterone Product Jun 01, 2005 45: 614-619

SK Gupta, BM Yih, L Atkinson, J Longstreth The effect of food, time of dosing, and body position on the 0 19 1,116 1,135 4,169 pharmacokinetics and pharmacodynamics of verapamil and norverapamil Nov 01, 1995 35: 1083-1093

Shiew-Mei Huang, Lawrence J. Lesko Drug-Drug, Drug-Dietary Supplement, and Drug-Citrus Fruit and 284 167 665 1,116 1,034 Other Food Interactions: What Have We Learned? Jun 01, 2004 44: 559-569

David J. Greenblatt, Lisa L. von Moltke Interaction of Warfarin With Drugs, Natural Substances, and 263 240 601 1,104 789 Foods Feb 01, 2005 45: 127-132

Gary A. Herman, Arthur Bergman, Fang Liu, Cathy Stevens, Amy Q. Wang, Wei Zeng, Li Chen, Karen Snyder, Deborah Hilliard, Michael Tanen, Wesley Tanaka, Alan G. Meehan, Kenneth Lasseter, Stacy 347 408 332 1,087 243 Dilzer, Robert Blum, John A. Wagner Pharmacokinetics and Pharmacodynamic Effects of the Oral DPP-4 Inhibitor Sitagliptin in Middle-Aged Obese Subjects Aug 01, 2006 46: 876-886

Section: Drug Interactions S. U. Mertens-Talcott, I. Zadezensky, W. V. De Castro, H. Derendorf, V. Butterweck 309 327 366 1,002 121 Grapefruit-Drug Interactions: Can Interactions With Drugs Be Avoided? Dec 01, 2006 46: 1390-1416

1,938 2,016 7,994 11,948 2,769.1 (ave. age) Totals for Top 10 Articles January 2007 - March 2007

– 13 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications

Most-Cited Articles The following table lists JCP’s top 10 most-cited articles on the SAGE Journals Online and HighWire Press platforms. Data is cumulative for all JCP content hosted online by HighWire and does not include citations by other journals that are not hosted by SJO or HighWire. This data enables us to see which journals sharing JCP’s online environment cite it most.

Cumulative Top 10 Most-Cited JCP Articles by Journals also Hosted on HighWire Press Platform Cites Article A Van Hecken, JI Schwartz, M Depre, I De Lepeleire, A Dallob, W Tanaka, K Wynants, A Buntinx, J Arnout, PH Wong, DL Ebel, BJ Gertz, PJ De Schepper 37 Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers Oct 01, 2000; 40: 1109-1120 K Venkatakrishnan, LL Von Moltke, DJ Greenblatt Human drug metabolism and the cytochromes P450: application and relevance of in 36 vitro models Nov 01, 2001; 41: 1149-1179

Jang-Ik Lee, Gilbert J. Burckart 32 Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target Nov 01, 1998; 38: 981-993

EM Vaughan Williams 30 A classification of antiarrhythmic actions reassessed after a decade of new drugs Apr 01, 1984; 24: 129-147 PD Kroboth, FS Salek, AL Pittenger, TJ Fabian, RF Frye 30 DHEA and DHEA-S: a review Apr 01, 1999; 39: 327-348 PT Leese, RC Hubbard, A Karim, PC Isakson, SS Yu, GS Geis Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy 29 adults: a randomized, controlled trial Feb 01, 2000; 40: 124-132 LL von Moltke, DJ Greenblatt, J Schmider, SX Duan, CE Wright, JS Harmatz, RI Shader Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, 23 norfluoxetine, and by azole antifungal agents Sep 01, 1996; 36: 783-791 LL von Moltke, DJ Greenblatt, JM Grassi, BW Granda, SX Duan, SM Fogelman, JP Daily, JS Harmatz, RI Shader 23 Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir Feb 01, 1998; 38: 106-111 DW Northfelt, FJ Martin, P Working, PA Volberding, J Russell, M Newman, MA Amantea, LD Kaplan Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: 21 pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma Jan 01, 1996; 36: 55-63 R Bullingham, S Monroe, A Nicholls, M Hale Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects 19 after single-dose oral and intravenous administration Apr 01, 1996; 36: 315-324

In the fall of 2006, SAGE subscribed to the Thomson Web of Science® Database, which tracks citation activity for journals indexed by the Web of Science®. We are now able to provide detailed reports of the most-cited JCP articles and authors from the Web of Science®, which provides not only a good snapshot of the most relevant articles for citation but an indication of which articles are contributing most significantly to JCP’s Impact Factor.

The chart below shows the top 10 most-cited articles from publication year 2003. Please note that the number of citations refers to the times the article has been cited in other journals indexed in the Web of Science® only (i.e. journals which receive an Impact Factor), and is not comprehensive across all journals in the field.

Top 10 Most-Cited Articles, 2002-2007 ® According to Thomson Web of Science Cites Article Yates CR, Zhang WH, Song PF, et al The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral 56 disposition in renal transplant patients 43 (6): 555-564 JUN 2003 Timmer W, Leclerc V, Birraux G, et al. The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced 51 asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo 42 (3): 297-303 MAR 2002 Chen TL, Berenson J, Vescio R, et al. Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with 49 bone metastases 42 (11): 1228-1236 NOV 2002 Kivikko M, Antila S, Eha J, et al. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its 48 metabolites during an extended infusion in patients with severe heart failure 42 (1): 43-51 JAN 2002 Bjornsson TD, Callaghan JT, Einolf HJ, et al. Pharmacogenetics and pharmacogenomics in drug development and regulatory 43 decision making: Report of the first FDA-PWG-PhRMA-DruSafe workshop 43 (4): 342-358 APR 2003 Lesko LJ, Salerno RA, Spear BB, et al. Pharmacogenetics and pharmacogenomics in drug development and regulatory 43 decision making: Report of the first FDA-PWG-PhRMA-DruSafe workshop 43 (4): 342-358 APR 2003 Galanello R, Piga A, Alberti D, et al. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating 41 agent in patients with transfusion-dependent iron overload due to beta-thalassemia 43 (6): 565-572 JUN 2003 Mechoulam R, Parker LA, Gallily R 41 Cannabidiol: An overview of some pharmacological aspects 42 (11): 11S-19S Suppl. S NOV 2002 Rohatagi S, Arya V, Zech K, et al. 36 Population pharmacokinetics and pharmacodynamics of ciclesonide 43 (4): 365-378 APR 2003 Perloff MD, von Moltke LL, Greenblatt DJ 34 Fexofenadine transport in Caco-2 cells: Inhibition with verapamil and ritonavir 42 (11): 1269-1274 NOV 2002

Referrer Statistics The following table shows the volume of traffic that has come to JCP’s homepage on SAGE Journals Online via various referring sites. The data vividly illustrates the importance of Google, Google Scholar, and PubMed as research tools, with the heavy traffic they refer to the JCP site resulting in full-text downloads.

JCP Referrer Statistics, May 2005 – Feb 2007 Referring Site HighWire NLM Google Portal PubMed Scholar Google Yahoo MSN Home Page 2,341 1 2 24,129 2,709 1,468 TOCs 2 0 1 2,640 728 118 All Article Hits 12,894 57,428 76,511 431,023 12,872 1,347 Abstract Views 6,965 653 71,887 295,966 10,191 633 Full Text Views 839 34,938 4,393 116,447 2,589 704 PDF Views 5,090 21,837 231 18,610 92 10 TOTAL 15,237 57,429 76,514 457,792 16,309 2,933 PERCENTAGE 2% 9% 12% 73% 3% 0%

Pay-Per-View Pay-Per-View allows non-member individuals and non-subscribing institutions to access online content from JCP for a fee by buying a downloaded article online. We are pleased to report that JCP continues to enjoy a substantial amount of PPV activity. During the first quarter of 2007, 233 pay-per- view transactions were logged for total revenues of $5,825.

Marketing

Strategy SAGE is pleased to present the ACCP with a summary of marketing activities for the first quarter of 2007. In addition to the new consortia agreements our sales teams have recently signed, JCP continues to receive considerable exposure through our direct marketing efforts.

Highlights so far this year include mailing a brochure internationally, deploying several email campaigns, and giving JCP extensive coverage at conferences.

All of the marketing efforts we have initiated and will continue to implement are aimed at achieving the following marketing goals:

1. To retain and increase traditional library subscriptions 2. To increase online access and usage 3. To assist with the quality and quantity of manuscript submissions 4. To help the ACCP increase its visibility to recruit new members

At SAGE we utilize a multi-channel approach to achieve the aforementioned goals, and JCP continues to receive considerable domestic and international coverage via direct mail and email campaigns, print and web advertising, and conference displays.

Direct Mail and Email Summary The following table summarizes all direct mail and email activities featuring JCP from January through March 2007.

January – March 2007 Direct Mail and Email Campaigns

Date Promotion Quantity List Selection

Email to Previous Pay-per- • Customers who have purchased individual JCP articles January 1,394 View Customers online using Pay-per-View in the last year • Biomedical Research, Diabetes, Metabolism, February Call for Papers Email 6,364 Pharmacology, Clinical Therapeutics • SAGE house names in pharmacology and toxicology Pharmacology & Toxicology March 7,000 Purchased emails from MedList in pharmacology and Newsletter Email • toxicology • Society for Clinical Trials March JCP Brochure 5,987 • American College of Clinical Pharmacy • Controlled Release Society

Quarterly Promotional Summary This table summarizes all promotional activities featuring JCP in the first quarter of 2007.

Quarter Direct Mail / Email Advertising / Other

January-March SAGE Annual Journals • JCP Email Alerts Catalog • Free online sample issue • iPod Alerts promotion SAGE Science, Technology, • SAGE Free Access in Celebration and Medicine Catalog of Bacfkile (February) • Pharmacology and Toxicology JCP PPV Email Free Trial (March and April)

JCP Call for Papers Email

Pharmacology and Toxicology Newsletter Email

JCP Brochure

Conferences We display JCP at many meetings throughout the year, both domestically and internationally. The following is a listing of conventions at which SAGE promoted the journal from January through March 2007.

2007 Conferences Conference Location Date

American Library Association - Midwinter Seattle, WA January 19-22

LabAutomation Palm Springs, CA January 27-30 American Academy of Hospice and Palliative Salt Lake City, UT February 14-17 Medicine American Academy of Orthopaedic Surgeons San Diego, CA February 14-18

American Association of Geriatric Psychiatrists New Orleans, LA March 1-4

American College of Cardiology New Orleans, March 24-27

Society of Toxicology Charlotte, NC March 25-28

Association of College & Research Libraries Baltimore, MD March 29-31 – 17 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications

Assisting with ACCP Membership Growth All JCP marketing activities include mention of ACCP, whether it is a detailed description of the association, a listing of ACCP’s URL, or the association’s logo, depending on space limitations. JCP’s homepage promotes the ACCP and includes links to http://www.accp1.org . SAGE is delighted to assist ACCP in these different ways because we believe a strong, healthy association contributes to a successful publications program.

Institutional Marketing Libraries are our primary customer base, and we continuously brand SAGE and promote our products and services to the librarian market throughout the year. In addition to sales and customer service support, we maintain close ties with the library community through:

• Quarterly Librarians’ e-Newsletters featuring company and product news and special offers. • A “Librarians’ Site” hosted on our corporate homepage providing relevant information to librarians about our journals program. • Special announcements via subscription agents about, pricing, policy changes, new journals, and renewals. • Advertisements in library publications, such as Library Journal, and library conference programs. • Press releases aimed at library and scholarly publishing media outlets. • High profile exhibits and receptions at major national and international library conferences, including the American Library Association (ALA), Medical Library Association (MLA), Special Library Association (SLA), Association of College and Research Libraries (ACRL), the International Federation of Library Associations (IFLA), the Charleston Conference, Internet Librarian, London Online, and the Frankfurt Book Fair. • Funding through grants and sponsorships for library events, conferences and particular divisions of library associations. • Annual Library Advisory Board meetings where we solicit advice from our handpicked panel of experienced librarians regarding developments in the industry, difficulties facing librarians, and new initiatives and product offerings being proposed by SAGE. • Ongoing interviews conducted by our global library/consortia sales team and frequent visits to individual libraries by marketing and editorial staff.

JCP Email Alerts To bolster both retention and growth of subscribers as well as increase online usage, we continue to promote the JCP Email Alerts service. Through this service, the tables of contents for each issue of the Journal are sent via email to registrants before the publication is available in print. To register, one need only access the journal’s homepage at http://jcp.sagepub.com and click on “Email Alerts”.

We are pleased to report that the number of registrants continues to increase with each report. JCP currently has 1,001 individuals registered for this service, an increase of 81 new alerts since our 2006 fourth quarter report.

This year, as in 2006, SAGE has set a goal to significantly increase the number of users of our Journal Email Alerts service. An incentive campaign to entice people to register will run during 2007 with an – 18 – © SAGE Publications Confidential to the JCP Editorial Board and SAGE Publications iPod nano (PRODUCT) RED Special Edition given away each month. To promote the campaign, we are running the following web ad across SJO and in our email campaigns.

Appendix: JCP’s Publishing Team at SAGE

Pat Chojnicki, Publishing Editor Supervisor Valerie Johns, Senior Marketing Manager General oversight of JCP operations at SAGE Point of contact for marketing and promotion [email protected] [email protected] 805-410-7210 805-410-7778

Kathryn Journey, Production Editor Kimie Halberstadt, Peer Review Specialist Point of contact for production and scheduling Coordinator of online editorial peer review systems [email protected] [email protected] 805-410-7579 805-410-7289

Bob Vrooman, Director of Commercial Sales Karen Ehrmann, Permissions Editor Oversees commercial sales activities, including Point of contact for all permissions requests commercial reprints, advertising, and sponsored [email protected] supplements 805-410-7735 [email protected] 805-410-7594 Blaise Simqu, President and CEO JCP Executive Sponsor Eddie Santos, Association Liaison [email protected] Membership list management and member online 805-410-7520 access eddie.santos.sagepub.com 805-410-7528

SAGE Main Numbers: Phone: 805-499-0721 Toll free: 800-818-7243 Fax: 805-499-0871