Opportunities and Risks of Nanomaterials
Total Page:16
File Type:pdf, Size:1020Kb
National Research Programme NRP 64 Opportunities and Risks of Nanomaterials Results, Outcome and Perspectives – Final Brochure Steering committee members: • Prof. em. Peter Gehr, Institute of Anatomy, University of Berne, CH (President) • Prof. em. Ueli Aebi, M.E. Müller Institute for Structural Biology, Biozentrum, University of Basel, CH • Prof. Heinrich Hofmann, Institute of Material Science, EPF Lausanne, CH • Prof. Patrick Hunziker, Department of Internal Medicine, University Hospital of Basel, CH • Prof. Andrew Maynard, Risk Innovation Lab, School for the Future of Innovation in Society, Arizona State University, Tempe, AZ, USA. • Prof. Wolfgang Parak, Fachbereich Physik, Philipps-Universität Marburg, D • Prof. Anders Baun, NanoDTU, Department of Environmental Engineering, Technical University of Denmark, DK • Prof. Vicki Stone, School of Life Sciences, Heriot-Watt University, Edinburgh, UK Delegate of division Programmes of the national research council: • Prof. Frank Scheffold, Département de Physique, Université de Fribourg, CH Programme Manager: • Marjory Hunt, PhD, Swiss National Science Foundation (SNSF), Berne, CH Head of knowledge transfer: • Mark Bächer, Life Science Communication AG, Zurich, CH Representative of the federal administration: • Christoph Studer, PhD, Federal Office of Public Health (FOPH), Berne, CH www.nrp64.ch Cover: High concentration of liposomes in cancer cells. Photograph page 4: Light-activated nanohpharmaceuticals (in red) accumulated in cancer cells. CONTENTS INTRODUCTION ............................................................................................................................... 5 WHAT IS NANO? ............................................................................................................................... 6 Nanomaterials: An overview of the basics ................................................................................. 6 CHAPTER I ....................................................................................................................................... 8 HOW HARMLESS ARE THESE NANOS? ............................................................................................ 8 Deep inside the lungs ................................................................................................................... 8 For a better silica flow .................................................................................................................. 8 Wide-open doors ........................................................................................................................ 10 CHAPTER II .................................................................................................................................... 11 WHEN RISK TURNS INTO AN OPPORTUNITY ................................................................................ 11 Catching the burglar at the door ............................................................................................... 11 Nano therapists ........................................................................................................................... 12 CHAPTER III ................................................................................................................................... 14 BIG PROMISES .............................................................................................................................. 14 Nanocartilage for worn joints .................................................................................................... 14 Doping for lithium-ion batteries ............................................................................................... 15 Nano is not always better ........................................................................................................... 16 CHAPTER IV ................................................................................................................................... 17 ON LAND AND IN WATER ............................................................................................................... 17 Trojan horse ................................................................................................................................ 17 Diffused light ............................................................................................................................... 18 A farmer’s little helpers ............................................................................................................. 19 CHAPTER V ..................................................................................................................................... 20 FROM THE CRADLE TO THE GRAVE ................................................................................................ 20 Dangerously obstinate ................................................................................................................ 21 In the end poorly digestible ....................................................................................................... 22 CHAPTER VI ................................................................................................................................... 23 THE DEVIL IS IN THE DETAIL .......................................................................................................... 23 Better safe than sorry ................................................................................................................. 23 The dose makes the toxin .......................................................................................................... 24 CHAPTER VII .................................................................................................................................. 25 A WORTHY CAUSE ......................................................................................................................... 25 Cooperation networks ................................................................................................................ 26 CLOSING STATEMENT .................................................................................................................... 28 ALL’S (almost) WELL THAT ENDS WELL ......................................................................................... 28 NRP 64 : The 23 projects ............................................................................................................... 30 4 INTRODUCTION ive years of research, 23 research groups materials, in energy technology and in par- Fwith a total of 111 researchers, 150 publi- ticular, in the medical field. They analysed cations to date, numerous prizes and awards. in which phase of their life cycle – in the The National Research Programme «Oppor- fabrication, during the use, or, at the point of tunities and Risks of Nanomaterials» (NRP disposal – nanoparticles could pose a risk to 64), got off the ground at the start of 2010 the environment or to human health. To do so with a blanket loan of 12 million Swiss francs the researchers developed and tested various and represented a venture of considerable measuring methods and measuring devices, significance. And it pursued an ambitious goal: experimented with new applications and made understanding how the special characteristics astonishing discoveries. For example, that it of synthetic nanomaterials could be tapped is frequently enough to just make a minute into, yielding maximum profit, while at the change to the particle’s surface to end up with same time remaining as risk-free as possible. fundamental changes in their characteristics. Synthetic nanoparticles have long since be- After five years of intensive interdisciplinary come a part of everyday life, even if we are research, the increasingly interconnected Swiss not always aware of it. They are hidden in the nano research community has reached the most diverse range of consumer goods, such conclusion that the opportunities that synthetic as electronics, textiles and cosmetics, in food, nanomaterials present, outweigh the risks. Or sports equipment and building materials. They more precisely: that accurate knowledge about ensure that our spices do not clump up, that synthetic nanomaterials can aid in making use our chocolate icing has that mouth-watering of these materials’ unique properties so as to shine and our French dressing is as white transform any existing hazard potential into as snow. They make sweaty socks odour- yet further opportunities. At the same token, free and make bicycle frames ultra-light but NRP 64 – and this is of equal importance – also ultra-strong, too. And last but not least, in clearly shows where knowledge gaps still do the medical field, their targeted use aims at exist and where additional research efforts ensuring that a treatment is more accurate must be undertaken. And, that sustainable while having fewer side effects. innovation and safety research have to go hand in hand. Nanoparticles hold great promises. The fact that many substances show a completely different Because nanotechnology, as a versatile in- behaviour when they are present as minute terdisciplinary technology, will be around in particles, was already known before NRP future. The knowledge gathered by NRP 64 64. Gold nanoparticles, for instance, change will significantly contribute to exploiting its colour due to a physical change: the master use-potential for the economy, technology, glaziers in the middle ages already knew that life science and society at