Big Challenges Require Broad Thinking by ROB LAST Michigan State University
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Transgenic Maize Lines with Cell-Type Specific Expression of Fluorescent Proteins in Plastids
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Agronomy & Horticulture -- Faculty Publications Agronomy and Horticulture Department 2010 Transgenic maize lines with cell-type specific expression of fluorescent proteins in plastids Amir Sattarzadeh Cornell University, Ithaca Jonathan Fuller Boyce Thompson Institute for Plant Research Salvador Moguel University of Nebraska-Lincoln & Union College, Lincoln Katia Wostrikoff Boyce Thompson Institute for Plant Research & IBPC Shirley Sato University of Nebraska-Lincoln See next page for additional authors Follow this and additional works at: https://digitalcommons.unl.edu/agronomyfacpub Part of the Agricultural Science Commons, Agriculture Commons, Agronomy and Crop Sciences Commons, Botany Commons, Horticulture Commons, Other Plant Sciences Commons, and the Plant Biology Commons Sattarzadeh, Amir; Fuller, Jonathan; Moguel, Salvador; Wostrikoff, Katia; Sato, Shirley; Covshoff, Sarah; Clemente, Tom; Hanson, Maureen; and Stern, David, "Transgenic maize lines with cell-type specific expression of fluorescent proteins in plastids" (2010). Agronomy & Horticulture -- Faculty Publications. 1372. https://digitalcommons.unl.edu/agronomyfacpub/1372 This Article is brought to you for free and open access by the Agronomy and Horticulture Department at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Agronomy & Horticulture -- Faculty Publications by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors -
All in the Family: Is ME/CFS Inherited?
SPRING 2018 All in the Family: Is ME/CFS Inherited? The quest to understand We’ve long understood that physical cost. A task that was science fiction characteristics are be inherited and just a few short years ago. In the genetics and inherited that these same genes also contrib- near future, gene editing will allow traits is possibly one ute to our overall health and well- us to correct ‘faulty’ genes associ- ness. This includes the development ated with a range of human genetic of the oldest and most and progression of various diseases. disorders. exciting scientific Today, we know that genetic muta- tions can cause complex diseases, When discussing a complex disease endeavors. It is also a from diabetes to cancer, and that like ME/CFS, particularly a sensi- subject within ME/CFS genetic ‘predisposition’ can be a risk tive topic like inherited traits, it factor that shapes our health. helps to be mindful of at least three that remains poorly broad categories: classical genetics, understood. Our understanding of genetics has epigenetics, and pathogenic-host grown substantially. We can now interactions. » to page 4 Since people with ME/CFS can be read, map, interpret, and modify found within the same family more the building blocks that make up often than random association our DNA. Scientific advances now INSIDE would dictate, is there a possible allow us to identify genetic irregu- 2 SMCI This Quarter: A Summary of genetic component to ME/CFS? larities quickly and for a reasonable Our Work 5 SMCI Welcomes Two New Members to Its Board of Directors 6 What’s in a Definition? Finding a Common Language for ME/CFS 8 PEM: It’s Time to Retire the Term 9 Dr. -
The Value of Our ASPB Community by JUDY CALLIS UPDATE ASPB President, University of California, Davis
March/April 2020 • Volume 47, Number 2 p. 7 p. 8 p. 12 Journal Flexibility Zachary Lippman NEW COLUMN in the Troubling Wins 2020 National Times of COVID-19 Academy of Unsung Heroes: Sciences Prize Samantha Link THE NEWSLETTER OF THE AMERICAN SOCIETY OF PLANT BIOLOGISTS President’s Letter The Value of Our ASPB Community BY JUDY CALLIS UPDATE ASPB President, University of California, Davis As the impacts of the coronavirus his is an unprecedented resources on Plantae pandemic become ever more serious, and extraordinary support profession- ASPB’s Plant Biology 2020 contin- Ttime. The fabric of our als and students gency planning efforts have gathered personal and professional worldwide without pace. Among other possibilities, as lives is changing daily, and charge and provide of early April we are exploring the it will be different as you communities with feasibility of options for online access read this message than it was a forum for discus- to meeting content—including the when I wrote it a few weeks sion and resource networking and other peer-to-peer ago. Now more than ever, we sharing. Join Twitter connections that are such a vital should value our ASPB com- if you haven’t component of Plant Biology confer- munity. Indeed, none of us is already and follow ences. Decisions are still pending; alone. ASBP (@ASPB); we will share more detailed informa- The goals of this letter are post ideas, ask for tion as soon as we are able to do so. to point you toward resourc- suggestions, and In the meantime, we thank you for es that might be particularly list resource URLs. -
Dr. Maureen Hanson: from Plant Biology to ME/CFS Champion (Cont’D)
RESEARCH SOLVE ME/CFS INITIATIVE RESEARCH ADVISORY COUNCIL Anthony Komaroff, MD Dr. Maureen Hanson: Harvard Medical School From Plant Biology to Maureen Hanson, PhD ME/CFS Champion Cornell University Susan Levine, MD DR. MAUREEN HANSON is the Liberty Hyde Bailey Professor in the Depart- Medical Offce of Susan M. Levine, MD ment of Molecular Biology & Genetics at Cornell University and a member of the Solve ME/CFS Initiative (SMCI) Research Advisory Council (RAC). Notably, she is directing a National Institutes of Health (NIH) funded myalgic enceph- Jose Montoya, MD Stanford University alomyelitis/chronic fatigue syndrome (ME/CFS) Collaborative Research Center Medical Center recently established at Cornell following a competitive grant process. Over the next fve years, the Center will work on three parimary research projects and Peter Rowe, MD work cooperatively with a network of three other ME/CFS centers. We recently Johns Hopkins sat down to speak with Dr. Hanson about her work. Sheila Stewart, PhD If you had a magic wand, what are the top three barriers you would Washington University School remove frst in order to accelerate the discovery process or improve of Medicine the lives of patients? Tarek Absi, MD Despite recent increases in funds for ME/CFS at NIH, an important barrier is Vanderbilt University Medical the relatively modest amount of NIH support devoted to grant proposals to Center study ME/CFS. The funding rates of investigator-initiated proposals at most NIH Institutes is less than 20%. If proposals to study HIV and AIDS had been Daan Archer, MBA, MSc Massachussetts Institute of this low during the AIDS epidemic, many more years would have been need- Technology Media Lab ed to develop life-saving drugs. -
PLENARY SPEAKERS for PLANT CANADA 2019 ALL PLENARY TALKS WILL BE in ROZANSKI HALL Room 104
PLANT CANADA 2019 Time Monday July 8th Tuesday July 9th Wednesday July 10th Place Room: Rozanski 104 Room: Rozanski 104 Room: Rozanski 104 8-8:30 Coffee-break (concourse) Coffee-break (concourse) Coffee-break (concourse) Session Plant Biotechnology Agronomy Managing Plant Disease in Horticulture Chairs Dr. Rima Menassa & Dr. Helen Booker Dr. Lone Buchwaldt & Dr. Abdelali Hannoufa Dr. Valerie Gravel 8:30am Dr. Maureen Hanson Dr. D. Brian Fowler Dr. Mary Ruth McDonald Cornell University, NY University of Saskatchewan, SK University of Guelph, ON Improving photosynthesis in Winter wheat production in the Billions, trillions and C3 plants high winter stress climate of quadrillions: The challenge of western Canada managing clubroot on canola – An experiment in crop adaptation and vegetables 9:20am Dr. Bing Yang Dr. Clarence J Swanton Dr. Richard Bélanger University of Missouri, MO University of Guelph, ON Université Laval, Québec, QC Genome editing enables Plant competition and the A unique interaction with a disease resistance in rice physiology of fear biocontrol agent alters the parasitic activity of powdery mildews on plants 10:10am Dr. Leslie Sieburth Dr. Jaswinder Singh Dr. Diane G.O. Saunders University of Utah, UT McGill University, QC John Innes Centre, UK CSPB C.D. Nelson Award Address: Beyond transcription factors: New paradigms in the genetic The wheat-rust conflict: Shifty A degrading story of gene regulation of pre- and post- harvest enemies and the long reach of expression control grain germination in cereals genomics 11:00am Lunch at Creelman Hall Lunch at Creelman Hall Lunch at Creelman Hall Session Root evolution, Development and Function Chairs Dr. -
In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling
proteomes Article In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling Arnaud Germain , Susan M. Levine and Maureen R. Hanson * Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA; [email protected] (A.G.); [email protected] (S.M.L.) * Correspondence: [email protected]; Tel.: +1-607-254-4833 Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disease with worldwide prevalence and limited therapies exclusively aimed at treating symptoms. To gain insights into the molecular disruptions in ME/CFS, we utilized an aptamer-based technology that quantified 4790 unique human proteins, allowing us to obtain the largest proteomics dataset yet available for this disease, detecting highly abundant proteins as well as rare proteins over a nine- log dynamic range. We report a pilot study of 20 ME/CFS patients and 20 controls, all females. Significant differences in the levels of 19 proteins between cohorts implicate pathways related to the extracellular matrix, the immune system and cell–cell communication. Outputs of pathway and cluster analyses robustly highlight the ephrin pathway, which is involved in cell–cell signaling and regulation of an expansive variety of biological processes, including axon guidance, angiogenesis, epithelial cell migration, and immune response. Receiver Operating Characteristic (ROC) curve analyses distinguish the plasma proteomes of ME/CFS patients from controls with a high degree of accuracy (Area Under the Curve (AUC) > 0.85), and even higher when using protein ratios (AUC up to 0.95), that include some protein pairs with established biological relevance. -
The Many Legacies of ASPB by SALLY MACKENZIE University of Nebraska–Lincoln
May/June 2017 • Volume 44, Number 3 p. 4 p. 14 p. 21 ASPB Announces Jenna Gallegos ASPB Welcomes 2017 Award Awarded ASPB/AAAS Winnie Nham as Winners Mass Media New Education Fellowship Coordinator THE NEWSLETTER OF THE AMERICAN SOCIETY OF PLANT BIOLOGISTS President’s Letter The Many Legacies of ASPB BY SALLY MACKENZIE University of Nebraska–Lincoln FEBRUARY 14–17, 2018 t ASPB, so much has If ASPB is to continue its FEBRUARY 14–17, 2018 TUCSON,TUCSON, AZ AZ changed over the leadership role in plant biology, past few years. Our additional financial resources HILTON EL CONQUISTADOR RESORT A HILT ON EL CONQUISTADOR RESORT flagship journals are now will be needed to sustain these online-only and offer open activities. Library subscriptions access options; we welcome continue to be the largest reve- the initiation of our new jour- nue source for ASPB. But pres- nal, Plant Direct; and ASPB sure from governments around is set to better interconnect the world to implement open its members with the larger access publication of publicly plant science community funded research, coupled with by way of the Plantae digital declining congressional support ecosystem. The Society stands Sally Mackenzie for basic research and state behind a new annual meeting support for public universities, in phenomics, and it is playing a growing role has influenced those revenues, compelling in helping support meetings for a number the Society to seek other ways to ensure it of plant science groups. ASPB has recently remains fiscally sound. Consequently, ASPB expanded its outreach activities to represent is creating a mix of revenue sources that will and inform plant scientists, sponsoring the allow it to continue its many good works. -
American Society of Plant Biologists
2017 Election American Society of Plant Biologists Elected Member, Council (to serve 2017–2020) Christine Foyer of agriculture. She also recognizes the need to focus greater research attention on grain legumes to increase the contri- Christine Foyer is Professor of Plant Sciences at the Univer- bution of pulses to global food production and sustainable sity of Leeds in the U.K. Christine obtained her BSc at the University of Portsmouth, and her PhD at Kings College, agriculture and so eradicate hunger and malnutrition. London. She joined the Photosynthesis Research Group at Christine is the General Secretary of the Federation of the University of Sheffield for her postdoctoral research. European Societies of Plant Biologists and a member of the Christine was appointed as Research Director with her French Academy of Agriculture. She is an Associate Editor own group at the French National Institute for Agricultural for Plant, Cell and Environment and the Biochemical Journal. Research (INRA) in Versailles, France in 1998. Christine She received the inaugural Founders Award from Plant then became Head of Department, first at the Institute of Physiology in 2011. She has worked alongside colleagues Grassland and Environmental Research in Wales and then from ASPB in the Global Plant Council and the Society of at the Institute of Arable Crops Research (Rothamsted Re- search) in Harpenden, U.K. She joined Africa College at the Experimental Biology. University of Leeds in April, 2009. Christine is enthusiastic about this opportunity to contrib- Christine has always been fascinated by plant metabolism, ute to ASPB. She believes strongly that ASPB is a flagship particularly reduction/oxidation (redox) biology and asso- organization that promotes excellence in all areas of plant ciated signaling. -
Reactive Oxygen Species Are Crucial “Pro-Life “Survival Signals in Plants
King’s Research Portal DOI: 10.1016/j.freeradbiomed.2018.04.582 Document Version Peer reviewed version Link to publication record in King's Research Portal Citation for published version (APA): Breusegem, F. V., Foyer, C., & Mann, G. (2018). Reactive oxygen species are crucial “pro-life “survival signals in plants . Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2018.04.582 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rights Copyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights. •Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research. •You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. -
Researchers Engineer Plants for Far Higher Photosynthesis Efficiency
A genetically engineered tobacco plant developed by U.S. and U.K. scientists using genes from blue-green algae could lead the way to improving yields of major global crops by up to 60%. The research was aimed at speeding up the process of photosynthesis, whereby plants convert sunlight, water and carbon dioxide into oxygen and sugar. Rubisco is the enzyme in plants responsible for fixing carbon into molecules that form the building blocks of plants, but it is considered to be extremely inefficient as it often reacts with oxygen instead of CO2 - one of the reasons why it is likely the most abundant protein on the planet. What the scientists did was borrow a faster Rubisco enzyme from blue-green algae, or cyanobacterium, and put it into a tobacco plant. Tobacco plants are considered to be a common model organism for genetic engineering research. Teams led by Cornell University plant geneticist Maureen Hanson in the U.S. and Rothamsted Research plant physiologist Martin Parry in the U.K, worked in equal measure on the research, using Cornell's expertise in genetic engineering and Rothamsted's expertise in enzyme biochemistry. The researchers transferred the cyanobacterium Rubisco into chloroplasts of the tobacco plant. In some of the plants the researchers also added a bacterial protein that was thought to help Rubisco fold properly, while in others they added a bacterial protein that structurally supported Rubisco. Both lines of tobacco were able to use the Rubisco for photosynthesis, and both reacted with carbon dioxide and created new molecules faster than normal tobacco. -
Hacked Photosynthesis Could Boost Crop Yields Algal Enzyme Can Speed up Rate at Which Plants Make Food
NATURE | NEWS Hacked photosynthesis could boost crop yields Algal enzyme can speed up rate at which plants make food. Heidi Ledford 17 September 2014 chain45154/Moment/Getty Rice is one of the crops that could increase their yields by converting solar energy more efficiently. It is difficult to find fault with a process that can create food from sunlight, water and air, but for many plants, there is room for improvement. Researchers have taken an important step towards enhancing photosynthesis by engineering plants with enzymes from blue-green algae that speed up the process of converting carbon dioxide into sugars. The results, published today in Nature1, surmount a daunting hurdle on the path to boosting plant yields — a goal that is taking on increasing importance as the world’s population grows. “With the limited ability to increase land use for agriculture, there’s a huge interest in trying to improve yield across all the major crops,” says Steven Gutteridge, a research fellow at chemical firm DuPont’s crop-protection division in Newark, Delaware. Researchers have long wanted to increase yields by targeting Rubisco, the enzyme responsible for converting carbon dioxide into sugar. Rubisco is possibly the most abundant protein on Earth, and can account for up to half of all the soluble protein found in a leaf. But one reason for its abundance is its inefficiency: plants produce so much Rubisco in part to compensate for its slow catalysis. Some have estimated that tinkering with Rubisco and ways to boost the concentration of carbon dioxide around it could generate up to a 60% increase2 in the yields of crops such as rice and wheat. -
MBG Fall 2019- Spring 2020 Seminar Series Listing
MBG Fall 2019 Seminar Series 4pm/G-10 Biotechnology Building 08.23 Jay Hirsch: Professor of Biology, Director of Undergraduate Program in Neuroscience, University of Virginia Title: Dopamine dependent regulatory responses in flies and mice Host: Eric Alani and Mariana Wolfner Website: http://bio.as.virginia.edu/people/ih6u 08.30 Lan Huang: Professor, Department of Physiology & Biophysics, UC Irvine Title: “Cross-linking Mass Spectrometry for Defining Protein Interactions and Structures” Host: Haiyuan Yu Website: https://webfiles.uci.edu/lanhuang/www/ 09.06 Philippe Soriano: Professor, Icahn School of Medicine at Mount Sinai Title: Untangling signaling specificity in development, one phosphate at a time Host: Marcos Simoes-Costa Website: https://www.mountsinai.org/profiles/philippe-m-soriano 09.20 Yuxin Mao: Associate Professor, Molecular Biology & Genetics, Cornell University Title: “Ubiquitin hijacking in bacterial pathogen-host interactions” Website: https://mbg.cornell.edu/people/yuxin-mao/ 09.27 Klaas Van Wijk: Professor in the Section of Plant Biology, School for Integrative Plant Science, Cornell University Title: Chloroplast Proteostasis and the Clp protease system Host: Maureen Hanson Website: https://plantbio.cals.cornell.edu/people/klaas-van-wijk/ 10.04 Eva Nogales: Howard Hughes Medical Institute investigator; a Professor of Biochemistry and Molecular Biology at the University of California, Berkeley; and Senior Faculty Scientist at the Lawrence Berkeley National Laboratory Title: “Visualization of key protein complexes in